YU61793A - POSTUPAK ZA DOBIJANJE 5-SUPSTITUISANIH PIROL [2,3-d] PIRIMIDINA - Google Patents
POSTUPAK ZA DOBIJANJE 5-SUPSTITUISANIH PIROL [2,3-d] PIRIMIDINAInfo
- Publication number
- YU61793A YU61793A YU61793A YU61793A YU61793A YU 61793 A YU61793 A YU 61793A YU 61793 A YU61793 A YU 61793A YU 61793 A YU61793 A YU 61793A YU 61793 A YU61793 A YU 61793A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- substituted
- pirol
- pyrimidine
- procedure
- obtaining
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 241001053161 Oriolus oriolus Species 0.000 title 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 2
- -1 5-substituted pyrrole Chemical class 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 230000003432 anti-folate effect Effects 0.000 abstract 1
- 229940127074 antifolate Drugs 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000004052 folic acid antagonist Substances 0.000 abstract 1
- 229910052740 iodine Chemical group 0.000 abstract 1
- 239000011630 iodine Chemical group 0.000 abstract 1
- 150000003230 pyrimidines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95151592A | 1992-09-25 | 1992-09-25 | |
| US08/066,831 US5416211A (en) | 1992-09-25 | 1993-05-24 | Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU61793A true YU61793A (sh) | 1997-05-28 |
Family
ID=25491768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU61793A YU61793A (sh) | 1992-09-25 | 1993-09-24 | POSTUPAK ZA DOBIJANJE 5-SUPSTITUISANIH PIROL [2,3-d] PIRIMIDINA |
Country Status (6)
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL107041A (en) * | 1992-09-25 | 2000-02-17 | Lilly Co Eli | Process for preparing omega(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo-6-¬2,3-d¾pyrimidin-5-YL)alkarylcarboxylic acids and N-(omega-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo¬2,3-d¾pyrimidin-5-YL)alk-aroyl-4-glutamic acids |
| US7863444B2 (en) | 1997-03-19 | 2011-01-04 | Abbott Laboratories | 4-aminopyrrolopyrimidines as kinase inhibitors |
| KR20010030712A (ko) * | 1997-09-26 | 2001-04-16 | 피터 지. 스트링거 | 항엽산제 제조에 유용한 방법 및 중간체 |
| ZA987550B (en) * | 1997-09-26 | 2000-02-21 | Lilly Co Eli | Processes and intermediates useful to make antifolates. |
| US6713474B2 (en) | 1998-09-18 | 2004-03-30 | Abbott Gmbh & Co. Kg | Pyrrolopyrimidines as therapeutic agents |
| US7071199B1 (en) | 1999-09-17 | 2006-07-04 | Abbott Gmbh & Cco. Kg | Kinase inhibitors as therapeutic agents |
| DE60100750T2 (de) * | 2000-02-25 | 2004-07-29 | Eli Lilly And Co., Indianapolis | NEUE KRISTALLINE FORM VON N-[4-[2-(2-AMINO-4,7-DIHYDRO-4-OXO-3H-PYRROLO[2,3-d]-PYRIMIDIN-5-YL)ETHYL]BENZOYL]-L-GLUTAMINSÄURE UND VERFAHREN FÜR IHRE HERSTELLUNG |
| KR101359838B1 (ko) * | 2006-08-14 | 2014-02-07 | 시코르, 인크. | 페메트렉세드 이산의 결정형 및 이의 제조 방법 |
| JP2008543973A (ja) * | 2006-08-14 | 2008-12-04 | シコール インコーポレイティド | ペメトレキセドの中間体の調製方法 |
| KR20090052355A (ko) * | 2006-08-14 | 2009-05-25 | 시코르, 인크. | 순도가 높은 페메트렉세드 이산 및 이의 제조 방법 |
| WO2008021411A2 (en) * | 2006-08-14 | 2008-02-21 | Sicor Inc. | Processes for the preparation of lyophilized pharmaceutically acceptable salts of pemetrexed diacid |
| CN101687872A (zh) * | 2007-04-03 | 2010-03-31 | 雷迪博士实验室有限公司 | 培美曲塞的固体形式 |
| EP2008995B1 (en) | 2007-06-29 | 2013-09-11 | Ricoh Company, Ltd. | Azo compound and method of preparing the azo compound |
| US20090069349A1 (en) * | 2007-09-12 | 2009-03-12 | Protia, Llc | Deuterium-enriched pemetrexed |
| CN101684121B (zh) * | 2008-09-22 | 2013-04-03 | 重庆医药工业研究院有限责任公司 | 培美曲塞二酸的新晶型及其制备方法 |
| TW201118098A (en) * | 2009-08-13 | 2011-06-01 | Reddy S Lab Liimited Dr | Processes for preparing pemetrexed |
| US20130183268A1 (en) | 2010-07-19 | 2013-07-18 | Bayer Healthcare Llc | Drug combinations with fluoro-substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions |
| IT1401677B1 (it) * | 2010-07-22 | 2013-08-02 | Chemi Spa | Nuovo processo per la sintesi di pemetrexed sale disodico |
| CN102372719B (zh) * | 2010-08-26 | 2013-10-30 | 齐鲁制药有限公司 | 培美曲塞二甲酯对甲苯磺酸盐晶型及其制备方法 |
| WO2012056285A1 (en) | 2010-10-25 | 2012-05-03 | Fresenius Kabi Oncology Ltd. | An improved process for the preparation of pemetrexed |
| KR101308767B1 (ko) | 2011-01-20 | 2013-12-31 | 에스티팜 주식회사 | 고 순도 페메트렉세드 디에틸 에스테르의 제조방법 및 이 방법을 포함하는 페메트렉세드 이나트륨염의 제조방법 |
| ITRM20120398A1 (it) * | 2012-08-08 | 2014-02-09 | Berlin Chemie Ag | Procedimento di sintesi pemetrexed e suo sale di lisina. |
| CN102887902B (zh) * | 2012-10-10 | 2015-05-20 | 北京莱瑞森医药科技有限公司 | 一种合成高纯度培美酸的制备工艺 |
| CN103086912A (zh) * | 2012-11-14 | 2013-05-08 | 湖北一半天制药有限公司 | 用于制备培美曲塞及其中间体的方法 |
| US20160051679A1 (en) | 2013-04-12 | 2016-02-25 | Actavis Group Ptc Ehf. | Pemetrexed Formulation |
| US20160145260A1 (en) | 2013-06-14 | 2016-05-26 | Synthon B.V. | Stable pemetrexed arginine salt and compositions comprising it |
| CN107628947B (zh) * | 2017-09-14 | 2020-07-28 | 浙江工业大学 | 一种培美曲塞二钠关键中间体的制备方法 |
| US12280053B2 (en) | 2019-05-01 | 2025-04-22 | Intas Pharmaceuticals Ltd. | Stable, ready to use aqueous pharmaceutical composition of pemetrexed |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO169490C (no) * | 1988-03-24 | 1992-07-01 | Takeda Chemical Industries Ltd | Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater |
| JP2983254B2 (ja) * | 1989-06-14 | 1999-11-29 | 武田薬品工業株式会社 | ピロロ〔２，３―ｄ〕ピリミジン誘導体の製造法およびその中間体 |
| AU654140B2 (en) * | 1990-07-31 | 1994-10-27 | Lilly Industries Limited | N-benzyl indoles, processes for their preparation or pharmaceutical compositions containing them |
-
1993
- 1993-05-24 US US08/066,831 patent/US5416211A/en not_active Expired - Fee Related
- 1993-09-20 ZA ZA936945A patent/ZA936945B/xx unknown
- 1993-09-21 TW TW082107742A patent/TW228522B/zh active
- 1993-09-23 UA UA93002124A patent/UA34423C2/uk unknown
- 1993-09-24 KR KR1019930019606A patent/KR100297957B1/ko not_active Expired - Fee Related
- 1993-09-24 YU YU61793A patent/YU61793A/sh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA936945B (en) | 1995-03-20 |
| KR100297957B1 (ko) | 2001-10-24 |
| TW228522B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1994-08-21 |
| US5416211A (en) | 1995-05-16 |
| KR940007034A (ko) | 1994-04-26 |
| UA34423C2 (uk) | 2001-03-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| YU61793A (sh) | POSTUPAK ZA DOBIJANJE 5-SUPSTITUISANIH PIROL [2,3-d] PIRIMIDINA | |
| MY108967A (en) | Triazolopyridazine compounds, their production and use | |
| BG98740A (en) | Substituted pyrazolylpyrazoles, methods for their preparation, preparation of intermediate products and the usage of the compounds as herbicides | |
| DE69324923D1 (de) | Antiretrovirale, enantiomere Nukleotid-Analoge | |
| ES471526A1 (es) | Procedimiento para la preparacion de derivados de acido fe- noxi-feniltio-alcan-carboxilico | |
| GR860049B (en) | Pyrazole sulfonamide derivative process for its production and herbicide containing it | |
| AU628521B2 (en) | Improvements in or relating to organic compounds | |
| IE781533L (en) | Herbicidal 2-(or 4-) amino-5-alkylthiopyrimidines | |
| DE3861173D1 (de) | Hydroxyalkyl-azolyl-derivate. | |
| YU45695B (sh) | Postupak za dobijanje novih 6-alkiliden-penema sa beta-laktamaza inhibitorskim i antibakterijskim osobinama | |
| HK110193A (en) | Amine derivatives, processes for their production and their use | |
| ES8401930A1 (es) | Un procedimiento para preparar derivados de amida del acido nitrobenzoico. | |
| MY110751A (en) | Positive inotropic and lusitropic pyrroloquinolinone derivatives | |
| IT1238084B (it) | Procedimento per la preparazione di nitrili aromatici | |
| DK0873327T3 (da) | Fremgangsmåde til fremstilling af 2-chlor-5-chlormethyl-thiazol | |
| ES465927A1 (es) | Un procedimiento para la produccion de compuestos tricicli- cos | |
| GB1498931A (en) | Tetrahalopentyl ketone derivatives processes for producing them and their conversion to beta-dihaloethenylcyclopropane derivatives | |
| DE69814837D1 (de) | Verfahren zur Herstellung von Heteroaryl-Zink-Halogeniden | |
| ES458808A1 (es) | Un procedimiento para la preparacion de una pirazolopirimi- dina. | |
| YU74501A (sh) | Sinteza 3-amino-3-aril propionata | |
| ES8703484A1 (es) | Procedimiento para preparar esteres de acidos 6-bromopiridin-2-il-fosforicos | |
| DK0614890T3 (da) | Fremgangsmåde til fremstilling af eventuelt 2-substituerede 5-chlorimidazoler. | |
| AU519287B2 (en) | Imidazo(1,2-alpha) imidazole derivatives | |
| GB1413286A (en) | Thiocarboxy esters and their use as herbicides | |
| JPS5651467A (en) | Manufacture of 55*2*2*22trihalogenoethyl**4*44 dialkylltetrahydrofurann22one and iminium salt thereof |