YU46172B - Postupak za dobijanje penem derivata - Google Patents
Postupak za dobijanje penem derivataInfo
- Publication number
- YU46172B YU46172B YU104986A YU104986A YU46172B YU 46172 B YU46172 B YU 46172B YU 104986 A YU104986 A YU 104986A YU 104986 A YU104986 A YU 104986A YU 46172 B YU46172 B YU 46172B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- procedure
- obtaining
- penem derivatives
- penem
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pens And Brushes (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Steroid Compounds (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Electroluminescent Light Sources (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Electrotherapy Devices (AREA)
- Materials For Medical Uses (AREA)
- Inks, Pencil-Leads, Or Crayons (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cephalosporin Compounds (AREA)
Abstract
predstavljenih sledecom opstom formulom: (I) u kojoj supstituent R1 predstavlja vodonik, C1-C6 alkil ili hidroksi C1-C6 alkil grupu; COOR2 predstavlja karboksilnu grupu ili karbok-silatni anjon i R2 moze biti estarski ostatak koji takodje moze dejstvovati istovremeno kao zastitna grupa; i R3 predstavlja supstituisanu (R4) ili nesupstituisanu bicikloheterociklicnu grupu sledece opste formule: u kojoj je m 1, 2 ili 3, Q je -CH, -C ili -N, dok parcijalna struktura R3 predstavljena sledecom opstom formulom: jeste 5- ili 6-clani heterociklican prsten koji sadrzi azot ili heterocik-lican prsten koji sadrzi kvaternerni azot, pri cemu je heterociklican prsten koji sadrzi azot zasiceni ili nezasiceni heterociklican prsten koji ima 1 do 4 hetero atoma izabrana iz grupe koja sadrzi kiseonik, sumpor i azot; R4 moze ali ne mora imati supstituent i predstavlja C1-C6 alkil, C2-C6 alkenil, C2-C6 alkinil, C3-C6 heterociklicnu grupu koja ukljucuje 1 do 4 hetero atoma izabranih iz grupe koja sadrzi kiseonik, azot i sumpor, C3-C6 cikloalifaticnu, C3-C6 cikloalifaticnu C1-C6 alkil, C3-C6 heterociklicnu C1-C6 alkil koja ukljucuje 1 do 4 hetero atoma izabranih iz grupe koja sadrzi kiseonik, azot i sumpor, C3-C6 nezasicenu aliciklicnu grupu, C3-C6 nezasicenu heteroalicik-licnu grupu koja ukljucuje 1 do 4 hetero atoma izabrana iz grupe koja sadrzi kiseonik, azot i sumpor, C3-C5 nezasicenu aliciklicnu C1-C6alkil, C3-C5 nezasicenu heteroaliciklicnu C1-C6 alkil grupu koja ukljucuje 1 do 4 hetero atoma izabrana iz grupe koja sadrzi kiseonik, azot i sumpor, C3-C6 aliciklicnu C1-C6 alkilidensku grupu u kojoj najmanje jedan atom ugljenika moze biti zamenjen sa hetero atomom koji je izabran iz grupe koja sadrzi kiseonik, azot i sumpor, fenil, fenil C1-C6 alkil, fenil C2-C6 alkenil, heteroaril, heteroaril C1-C6 alkil, fenil C2-C6 alkinil, heteroaromaticnu C2-C6 alkenil, heteroaromaticnu C2-C6 alkinil grupu u kojoj hetero atom heteroaromaticnog dela moze ukljucivati 1 do 4 hetero atoma izabranih iz grupe koja sadrzi kiseonikov, azotov i sumporov atom, ili grupu predstavljenu sledecom formulom: R4a - (CH2)m1 - Z-(CH)m-(gde je Z kiseonik, sumpor, SO, SO2 ili NH, m1 je O, 1 ili 2, m je 1, 2 ili 3 i R4a moze ali ne mora biti supstituisan i predstavlja C1-C6 alkil, C2-C6 alkenil, C2-C6 alkinil, C3-C6 aliciklicnu, C3-C6 nezasicenu aliciklicnu grupu, C3-C6 heteroaliciklicnu grupu koja ukljucuje 1 do 4 hetero atoma izabrana iz grupe koja sadrzi kiseonikov, azotov i sumporov atom, C3-C6 nezasicenu heteroaliciklicnu grupu koja ukljucuje 1 do 4 hetero atoma izabrana iz grupe koja sadrzi kiseonikov, azotov i sumporov atom, fenil, heteroaromaticnu grupu koja ukljucuje 1 do 4 heteroatoma izabrana iz grupe koja sadrzi kiseonikov, azotov i sumporov atom; supstituent R5+4 treba da je sposoban da bude najmanje jedan clan koji je nezavisno izabran iz grupe koja sadrzi C1-C6 alkil; C1-C6 alkil supstituisan sa amino, mononizialkilamino (koji moze biti opciono supstituisan na C1-C6 alkil delu), di-(opc
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13139485 | 1985-06-17 | ||
JP21342085 | 1985-09-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
YU104986A YU104986A (en) | 1988-02-29 |
YU46172B true YU46172B (sh) | 1993-05-28 |
Family
ID=26466241
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU104986A YU46172B (sh) | 1985-06-17 | 1986-06-17 | Postupak za dobijanje penem derivata |
Country Status (14)
Country | Link |
---|---|
US (2) | US4962202A (sh) |
EP (1) | EP0210883B1 (sh) |
JP (2) | JPH0826040B2 (sh) |
AT (1) | ATE118007T1 (sh) |
AU (2) | AU593558B2 (sh) |
CA (1) | CA1339860C (sh) |
DE (1) | DE3650221T2 (sh) |
DK (1) | DK171644B1 (sh) |
ES (1) | ES8801286A1 (sh) |
FI (1) | FI87218C (sh) |
GR (1) | GR861568B (sh) |
IE (1) | IE67525B1 (sh) |
NO (1) | NO167982C (sh) |
YU (1) | YU46172B (sh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1339860C (en) * | 1985-06-17 | 1998-05-12 | Tsunehiko Soga | Derivatives of penem |
DK175069B1 (da) * | 1986-03-11 | 2004-05-24 | Hoffmann La Roche | Pyrocatecholderivater |
JP2579472B2 (ja) * | 1986-12-17 | 1997-02-05 | 第一製薬株式会社 | ペネム化合物 |
JP2708576B2 (ja) * | 1988-11-08 | 1998-02-04 | 第一製薬株式会社 | カルバペネム誘導体 |
US5541694A (en) * | 1993-05-24 | 1996-07-30 | Nikon Corporation | Light shielding blade caulking pin |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4168314A (en) * | 1977-11-17 | 1979-09-18 | Merck & Co., Inc. | 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid |
JPS58198486A (ja) * | 1982-05-14 | 1983-11-18 | Sankyo Co Ltd | ペネムまたはカルバペネム−3−カルボン酸誘導体およびその製法 |
US4748162A (en) * | 1982-03-01 | 1988-05-31 | Merck & Co., Inc. | 6-substituted-2-carbaminidoyl-pen-2-em-3-carboxylic acids |
US4650794A (en) * | 1982-04-29 | 1987-03-17 | Merck & Co., Inc. | 6-(1-hydroxyethyl)-2-carbamimidoyl-pen-2-em-3-carboxylic acids |
JPS58180490A (ja) * | 1982-03-01 | 1983-10-21 | メルク・エンド・カムパニ−・インコ−ポレ−テツド | 6−置換−2−カルバムイミドイル−ペン−2−エム−3−カルボン酸 |
NO831160L (no) * | 1982-04-08 | 1983-10-10 | Erba Farmitalia | Fremstilling av substituerte penem-derivater |
ZA836966B (en) * | 1982-09-28 | 1984-04-25 | Bristol Myers Co | Carbapenem antibiotics |
ZA841781B (en) * | 1983-03-14 | 1985-07-31 | Schering Corp | Penim compounds,methods for their preparation and pharmaceutical compositions containing them |
US4772597A (en) * | 1983-10-14 | 1988-09-20 | Pfizer Inc. | 2-azacycloalkylthiopenem derivatives |
IE851586L (en) * | 1984-07-02 | 1986-01-02 | Interchem Internat S A | I methylcarbapenems having a 2-quaternary¹heteroarylalkylthio substituent |
CA1273011A (en) * | 1984-07-02 | 1990-08-21 | Susan M. Schmitt | Carbapenems having an externally alkylated mono- or bicyclic 2-quaternary heteroarylalkylthio substituent |
GB8509180D0 (en) * | 1985-04-10 | 1985-05-15 | Erba Farmitalia | Penem derivatives |
CA1339860C (en) * | 1985-06-17 | 1998-05-12 | Tsunehiko Soga | Derivatives of penem |
JP2579472B2 (ja) * | 1986-12-17 | 1997-02-05 | 第一製薬株式会社 | ペネム化合物 |
-
1986
- 1986-06-13 CA CA000511536A patent/CA1339860C/en not_active Expired - Fee Related
- 1986-06-16 IE IE159386A patent/IE67525B1/en not_active IP Right Cessation
- 1986-06-17 AT AT86401308T patent/ATE118007T1/de not_active IP Right Cessation
- 1986-06-17 DK DK283586A patent/DK171644B1/da not_active IP Right Cessation
- 1986-06-17 ES ES556137A patent/ES8801286A1/es not_active Expired
- 1986-06-17 GR GR861568A patent/GR861568B/el unknown
- 1986-06-17 NO NO862411A patent/NO167982C/no not_active IP Right Cessation
- 1986-06-17 FI FI862566A patent/FI87218C/fi not_active IP Right Cessation
- 1986-06-17 YU YU104986A patent/YU46172B/sh unknown
- 1986-06-17 AU AU58909/86A patent/AU593558B2/en not_active Ceased
- 1986-06-17 JP JP61141171A patent/JPH0826040B2/ja not_active Expired - Lifetime
- 1986-06-17 EP EP86401308A patent/EP0210883B1/en not_active Expired - Lifetime
- 1986-06-17 DE DE3650221T patent/DE3650221T2/de not_active Expired - Fee Related
-
1988
- 1988-01-11 US US07/117,617 patent/US4962202A/en not_active Expired - Fee Related
-
1989
- 1989-11-17 AU AU44784/89A patent/AU626606B2/en not_active Ceased
- 1989-12-07 US US07/449,391 patent/US5079357A/en not_active Expired - Fee Related
-
1993
- 1993-06-17 JP JP5145807A patent/JP2691678B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
NO862411L (no) | 1986-12-18 |
JPH06184146A (ja) | 1994-07-05 |
FI862566A0 (fi) | 1986-06-17 |
DE3650221D1 (de) | 1995-03-16 |
IE861593L (en) | 1986-12-17 |
AU4478489A (en) | 1990-03-08 |
FI87218B (fi) | 1992-08-31 |
IE67525B1 (en) | 1996-04-03 |
EP0210883A2 (en) | 1987-02-04 |
US4962202A (en) | 1990-10-09 |
NO167982B (no) | 1991-09-23 |
EP0210883A3 (en) | 1987-07-01 |
EP0210883B1 (en) | 1995-02-01 |
AU5890986A (en) | 1986-12-24 |
DK283586A (da) | 1986-12-18 |
AU593558B2 (en) | 1990-02-15 |
DE3650221T2 (de) | 1995-06-22 |
ES556137A0 (es) | 1988-01-01 |
ES8801286A1 (es) | 1988-01-01 |
ATE118007T1 (de) | 1995-02-15 |
DK283586D0 (da) | 1986-06-17 |
YU104986A (en) | 1988-02-29 |
DK171644B1 (da) | 1997-03-03 |
AU626606B2 (en) | 1992-08-06 |
NO862411D0 (no) | 1986-06-17 |
JP2691678B2 (ja) | 1997-12-17 |
JPH0826040B2 (ja) | 1996-03-13 |
NO167982C (no) | 1992-01-02 |
CA1339860C (en) | 1998-05-12 |
GR861568B (en) | 1986-10-17 |
FI862566A (fi) | 1986-12-18 |
JPS62149683A (ja) | 1987-07-03 |
US5079357A (en) | 1992-01-07 |
FI87218C (fi) | 1992-12-10 |
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