YU45965B - Postopek za pripravo cefemskih spojin - Google Patents

Postopek za pripravo cefemskih spojin

Info

Publication number
YU45965B
YU45965B YU76684A YU76684A YU45965B YU 45965 B YU45965 B YU 45965B YU 76684 A YU76684 A YU 76684A YU 76684 A YU76684 A YU 76684A YU 45965 B YU45965 B YU 45965B
Authority
YU
Yugoslavia
Prior art keywords
residue
group
hydrogen
general formula
compound
Prior art date
Application number
YU76684A
Other languages
English (en)
Other versions
YU76684A (en
Inventor
W. Schwab
W. Duerckheimer
R. Kirrstetter
R. Lattrell
Original Assignee
Hoechst Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag. filed Critical Hoechst Ag.
Publication of YU76684A publication Critical patent/YU76684A/xx
Publication of YU45965B publication Critical patent/YU45965B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

POSTOPEK ZA PRIPRAVO CEFEMSKIH SPOJIN, s splošno formulo kjer pomeni R tiazolilni ostanek ali 1,2,4-tiadiazolilni ostanek v katerih stoji R3 za vodik in B za amino skupino, in kjer pomeni R1 vodik, R2 metilno skupino, A kinolinijev ostanek , izokinolinijev ostanek metilkinolinijev ostanek ali priridinijev ostanek , ciklopenteno-ali ciklohekseno-piridinijev ostanek ali metilpiridinijev ostanek in v kateri stoji skupina R2-O v sin legi, označen s tem, da spojino s splošno formulo II kjer ima R1 v formuli I navedeni pomen, R7 pomeni skupino, ki se da zamenjati s tisto bazo, ki ustreza ostankom A v formuli I in R8 stoji za vodik ali zaščitno skupino za amino, presnovimo v aprotonskem topilu pri temperaturah med +10 in +80В° C z bazo, ki je osnova v formuli I definiranega ostanka A, in v prisotnosti tri-C1-C4-alkiljodosilana, pri čemer dodamo bazo v stehiometrični množini ali do dvajsetkratnem prebitku, ob tvorbi spojine s splošno formulo III, v kateri imajo R1, R8 in A zgoraj navedeni pomen, in a) v danem primeru prisono zaščitno skupino za amino odcepimo in b) spojino III, kjer pomeni R8 vodik, bodisi kot tako ali v obliki reakcijsko sposobnega derivata presnovimo z 2-sin-oksiminoocetno kislino s splošno formulo IV kjer imata R in R2 navedeni pomen, ali z derivatom te spojine, aktiviranim na karbonilni skupini. Prijava vsebuje še 1 odvisen zahtevek i 1 neovisen zahtevek.
YU76684A 1983-05-07 1984-04-27 Postopek za pripravo cefemskih spojin YU45965B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833316798 DE3316798A1 (de) 1983-05-07 1983-05-07 Verfahren zur herstellung von cephemverbindungen

Publications (2)

Publication Number Publication Date
YU76684A YU76684A (en) 1986-10-31
YU45965B true YU45965B (sh) 1992-12-21

Family

ID=6198462

Family Applications (1)

Application Number Title Priority Date Filing Date
YU76684A YU45965B (sh) 1983-05-07 1984-04-27 Postopek za pripravo cefemskih spojin

Country Status (24)

Country Link
US (1) US4667028A (sh)
EP (1) EP0124889A3 (sh)
JP (1) JPS6034972A (sh)
KR (1) KR910004332B1 (sh)
AU (1) AU575825B2 (sh)
CA (1) CA1224457A (sh)
CS (1) CS247081B2 (sh)
DD (1) DD251133A5 (sh)
DE (1) DE3316798A1 (sh)
DK (1) DK166282C (sh)
ES (1) ES8502445A1 (sh)
FI (1) FI82055C (sh)
HU (1) HU191683B (sh)
IL (1) IL71771A (sh)
MA (1) MA20110A1 (sh)
MT (1) MTP947B (sh)
MX (1) MX168599B (sh)
NO (1) NO841792L (sh)
NZ (1) NZ208064A (sh)
OA (1) OA07766A (sh)
PH (1) PH19554A (sh)
PT (1) PT78544B (sh)
YU (1) YU45965B (sh)
ZA (1) ZA843343B (sh)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60169486A (ja) * 1984-02-10 1985-09-02 Yamanouchi Pharmaceut Co Ltd ７−アミノ−３−置換メチル−３−セフエム−４−カルボン酸およびその低級アルキルシリル誘導体の製造法
IL74822A (en) * 1984-04-17 1989-06-30 Daiichi Seiyaku Co Cephalosporin derivatives and salts thereof and their preparation
US4788185A (en) * 1984-04-23 1988-11-29 Takeda Chemical Industries, Ltd. Cephalosporin compounds
ATE121746T1 (de) * 1984-11-23 1995-05-15 Biochemie Gmbh Verfahren zur herstellung bissilylierter 3- iodmethylcephalosporinderivaten.
ATE89826T1 (de) * 1985-03-01 1993-06-15 Takeda Chemical Industries Ltd Antibakterielle verbindungen, ihre herstellung und verwendung.
US4703118A (en) * 1985-04-08 1987-10-27 Eli Lilly And Company Synthesis of 3-iodomethyl cephalosporins
GB8519606D0 (en) * 1985-08-05 1985-09-11 Fujisawa Pharmaceutical Co 3 7-d substituted-3-cephem compounds
US4714760A (en) * 1985-08-20 1987-12-22 Bristol-Myers Company Cephalosporin intermediates
US4749522A (en) * 1985-10-31 1988-06-07 Angio-Medical Corporation Supercritical fluid extraction of animal derived materials
DE3542644A1 (de) * 1985-12-03 1987-06-04 Hoechst Ag Verfahren zur herstellung von cefodizim
CA1296012C (en) * 1986-03-19 1992-02-18 Susumu Nakagawa 6,7-dihydroxy-isoquinoline derivatives
US4868294A (en) * 1986-07-11 1989-09-19 Bristol-Myers Company Process for preparing cephalosporin intermediates
DE3706020A1 (de) * 1987-02-25 1988-09-08 Hoechst Ag Kristallisierte cephem-saeureadditionssalze und verfahren zu ihrer herstellung
TWI335332B (en) 2001-10-12 2011-01-01 Theravance Inc Cross-linked vancomycin-cephalosporin antibiotics
CN102002058B (zh) * 2010-11-05 2012-04-04 山东鲁抗立科药物化学有限公司 硫酸头孢喹肟的合成方法
EP3616695A1 (en) 2011-09-09 2020-03-04 Merck Sharp & Dohme Corp. Methods for treating intrapulmonary infections
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
KR102329764B1 (ko) 2013-03-15 2021-11-23 머크 샤프 앤드 돔 코포레이션 세프톨로잔 항균성 조성물
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
US20140274991A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane pharmaceutical compositions
EP3043797B1 (en) 2013-09-09 2020-04-08 Merck Sharp & Dohme Corp. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US20150094293A1 (en) 2013-09-27 2015-04-02 Calixa Therapeutics, Inc. Solid forms of ceftolozane
CN103601738A (zh) * 2013-12-04 2014-02-26 哈药集团制药总厂 一种头孢匹罗氢碘酸盐的制备方法
CN105646543B (zh) * 2016-03-17 2018-03-27 天津大学 一种头孢喹肟晶体及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR228726A1 (es) * 1978-05-26 1983-04-15 Glaxo Group Ltd Procedimiento para la preparacion del antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)acetamido)-3-(1-piridiniometil)cef-3-em-4-carboxilato
US4266049A (en) * 1980-02-20 1981-05-05 Eli Lilly And Company Process for 3-iodomethyl cephalosporins
US4367228A (en) * 1980-10-29 1983-01-04 Fujisawa Pharmaceutical Co., Ltd. Cephem compound and composition
US4336253A (en) * 1981-03-11 1982-06-22 Eli Lilly And Company Cephalosporin antibiotics
DE3118732A1 (de) * 1981-05-12 1982-12-02 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
AU557274B2 (en) * 1981-07-17 1986-12-18 Glaxo Group Limited Cephalosporin antibiotics
ZA826538B (en) * 1981-09-08 1984-04-25 Lilly Co Eli Thieno and furopyridinium-substituted cephalosporin derivatives
US4396619A (en) * 1981-09-08 1983-08-02 Eli Lilly And Company Cephalosporin betaines
US4396620A (en) * 1981-09-08 1983-08-02 Eli Lilly And Company Cephalosporin quinolinium betaines
US4402955A (en) * 1981-10-02 1983-09-06 Eli Lilly And Company Dioximino cephalosporin antibiotics

Also Published As

Publication number Publication date
HUT34506A (en) 1985-03-28
YU76684A (en) 1986-10-31
IL71771A (en) 1988-06-30
DE3316798A1 (de) 1984-11-08
MA20110A1 (fr) 1984-12-31
DK224284A (da) 1984-11-08
AU575825B2 (en) 1988-08-11
FI841764A0 (fi) 1984-05-03
IL71771A0 (en) 1984-09-30
NO841792L (no) 1984-11-08
KR840009116A (ko) 1984-12-24
ES532183A0 (es) 1985-01-01
OA07766A (fr) 1985-08-30
KR910004332B1 (ko) 1991-06-26
EP0124889A2 (de) 1984-11-14
FI82055C (fi) 1991-01-10
HU191683B (en) 1987-03-30
PH19554A (en) 1986-05-21
ES8502445A1 (es) 1985-01-01
DK224284D0 (da) 1984-05-04
CA1224457A (en) 1987-07-21
CS247081B2 (en) 1986-11-13
MTP947B (en) 1985-01-17
DK166282C (da) 1993-08-23
DD251133A5 (de) 1987-11-04
DK166282B (da) 1993-03-29
PT78544B (de) 1986-07-17
AU2770584A (en) 1984-11-08
NZ208064A (en) 1987-07-31
EP0124889A3 (de) 1985-11-27
US4667028A (en) 1987-05-19
FI841764A (fi) 1984-11-08
JPS6034972A (ja) 1985-02-22
MX168599B (es) 1993-06-01
ZA843343B (en) 1984-12-24
PT78544A (de) 1984-06-01
FI82055B (fi) 1990-09-28

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