YU45099B - Postupak za proizvodnju n-supstituisanih morfinana - Google Patents

Postupak za proizvodnju n-supstituisanih morfinana

Info

Publication number
YU45099B
YU45099B YU227772A YU227772A YU45099B YU 45099 B YU45099 B YU 45099B YU 227772 A YU227772 A YU 227772A YU 227772 A YU227772 A YU 227772A YU 45099 B YU45099 B YU 45099B
Authority
YU
Yugoslavia
Prior art keywords
compound
formula
carbon atoms
give
alkyl
Prior art date
Application number
YU227772A
Other languages
English (en)
Serbo-Croatian (sh)
Other versions
YU227772A (en
Inventor
I. Pachter
B. Bellean
I. Monković
Original Assignee
Bristol-Myers Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Company filed Critical Bristol-Myers Company
Publication of YU227772A publication Critical patent/YU227772A/xx
Publication of YU45099B publication Critical patent/YU45099B/sh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/36Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22Bridged ring systems
    • C07D221/28Morphinans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/04Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/26Phenanthrenes; Hydrogenated phenanthrenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
YU227772A 1971-09-08 1972-09-07 Postupak za proizvodnju n-supstituisanih morfinana YU45099B (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17883771A 1971-09-08 1971-09-08
US00217633A US3819635A (en) 1971-09-08 1972-01-13 14-hydroxymorphinan derivatives

Publications (2)

Publication Number Publication Date
YU227772A YU227772A (en) 1982-02-28
YU45099B true YU45099B (sh) 1992-07-20

Family

ID=26874723

Family Applications (1)

Application Number Title Priority Date Filing Date
YU227772A YU45099B (sh) 1971-09-08 1972-09-07 Postupak za proizvodnju n-supstituisanih morfinana

Country Status (19)

Country Link
US (1) US3819635A (de)
JP (1) JPS5310596B2 (de)
AU (1) AU470102B2 (de)
BE (1) BE788478A (de)
CA (1) CA999578A (de)
CH (1) CH590845A5 (de)
CY (1) CY980A (de)
DD (1) DD100255A5 (de)
DE (3) DE2265256C2 (de)
DK (1) DK141624B (de)
FR (1) FR2154481B1 (de)
GB (2) GB1412130A (de)
HK (1) HK2679A (de)
IE (2) IE36688B1 (de)
KE (1) KE2911A (de)
MY (1) MY7900027A (de)
NL (1) NL162072C (de)
SE (2) SE398877B (de)
YU (1) YU45099B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3910920A (en) * 1973-11-07 1975-10-07 Bristol Myers Co 3,14,17-Substituted-6,7-tetramethylenemorphinans
US3980641A (en) * 1975-07-31 1976-09-14 Bristol-Myers Company Process for the preparation of 14-hydroxymorphinans
US4017497A (en) * 1975-11-18 1977-04-12 Bristol-Myers Company Process for the preparation of 14-hydroxymorphinan derivatives
US4052389A (en) * 1976-03-23 1977-10-04 Bristol-Myers Company Derivatives of 9,10-dihydroxy-1-(p-alkoxybenzyl)-perhydroisoquinoline oxazine-3-one
US4139534A (en) * 1977-02-17 1979-02-13 Bristol-Myers Company Process for the preparation of 14-hydroxymorphinan derivatives
US4058531A (en) * 1976-03-23 1977-11-15 Bristol-Myers Company Process for the preparation of 14-hydroxymorphinan derivatives
JPS52136176A (en) * 1976-03-23 1977-11-14 Bristol Myers Co Method of improving 144hydroxymorphinan derivatives
GB1587831A (en) * 1977-03-23 1981-04-08 Reckitt & Colmann Prod Ltd Morphine derivatives
GB1593191A (en) * 1977-03-23 1981-07-15 Reckitt & Colmann Prod Ltd Derivatives of morphine
US4115389A (en) * 1977-05-02 1978-09-19 Bristol-Myers Company Process of N-demethylating (-)-1-(p-methoxybenzyl)-2-methyl-1,2,3,4,5,6,7,8-octahydroisoquinoline
US4338320A (en) * 1978-11-15 1982-07-06 The Board Of Regents Of The University Of Nebraska Esters of 6'-hydroxycinchonine, and a method of treating arrythmia with them
US4228285A (en) * 1979-02-28 1980-10-14 Bristol-Myers Company 14-Hydroxy-6-oxamorphinans and 14-hydroxy-6-oxaisomorphinans
US4272540A (en) * 1979-04-24 1981-06-09 Sisa, Incorporated 14-Methoxymorphinan-6-one compounds and therapeutic methods of treating pain and drug dependence with them
US4322427A (en) * 1981-04-16 1982-03-30 Bristol-Myers Company Analgetic compositions and methods of use
DE69414085T2 (de) * 1993-07-19 1999-03-18 Toray Industries, Inc., Tokio/Tokyo Wirkstoff zum schutze von gehirnzellen
AU686203B2 (en) * 1993-07-23 1998-02-05 Toray Industries, Inc. Morphinan derivative and medicinal use
CZ281174B6 (cs) * 1993-08-13 1996-07-17 Galena, A.S. Způsob přípravy 3,14ß-dihydroxy-17-normorfinanu
EP1056443B1 (de) 1998-02-25 2004-05-06 Abbott Laboratories Butorphanol enthaltende formulierungen mit verzögerter freisetzung
US20040167164A1 (en) * 1998-05-05 2004-08-26 Jose Pozuelo Compositions and methods for treating particular chemical addictions and mental illnesses
US7501433B2 (en) * 2002-05-17 2009-03-10 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US7923454B2 (en) 2002-05-17 2011-04-12 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
EP1506174B1 (de) 2002-05-17 2015-09-30 Taiwanj Pharmaceuticals Co., Ltd. Verwendung von naltrexon zur behandlung von nieren- und leberschäden
US8017622B2 (en) 2003-05-16 2011-09-13 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
CN103073496B (zh) * 2013-02-18 2015-08-26 苏州立新制药有限公司 右美沙芬的制备方法
JP6464181B2 (ja) 2014-10-14 2019-02-06 久光製薬株式会社 貼付剤

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3166559A (en) * 1965-01-19 J-lower alkoxy-x-phenyloxy-ix-hydroxy-
GB1028407A (en) * 1962-04-06 1966-05-04 Shionogi & Co Improvements in or relating to morphinan derivatives and their preparation
FR1362540A (fr) * 1963-04-05 1964-06-05 Shionogi & Co Dérivés n substitués du morphinane et leur production

Also Published As

Publication number Publication date
AU470102B2 (en) 1976-03-04
DK141624C (de) 1980-10-13
DE2265256C2 (de) 1985-10-24
JPS4834864A (de) 1973-05-22
US3819635A (en) 1974-06-25
YU227772A (en) 1982-02-28
HK2679A (en) 1979-01-19
GB1412130A (en) 1975-10-29
DE2265255C2 (de) 1986-06-05
GB1412129A (en) 1975-10-29
DE2265255A1 (de) 1977-01-27
MY7900027A (en) 1979-12-31
SE7506292L (sv) 1975-06-02
FR2154481B1 (de) 1976-04-23
IE36688B1 (en) 1977-02-02
DK141624B (da) 1980-05-12
SE398877B (sv) 1978-01-23
DD100255A5 (de) 1973-09-12
DE2265256A1 (de) 1977-01-27
FR2154481A1 (de) 1973-05-11
DE2243961A1 (de) 1973-04-05
NL162072C (nl) 1980-04-15
CA999578A (en) 1976-11-09
AU4622872A (en) 1974-03-07
CH590845A5 (de) 1977-08-31
KE2911A (en) 1979-01-26
IE36687B1 (en) 1977-02-02
NL7212176A (de) 1973-03-12
IE36687L (en) 1973-03-08
NL162072B (nl) 1979-11-15
BE788478A (fr) 1973-03-06
CY980A (en) 1979-03-23
DE2243961C2 (de) 1988-07-21
JPS5310596B2 (de) 1978-04-14
SE403286B (sv) 1978-08-07

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