BE788478A - Procede de preparation de composes analgesiques - Google Patents

Procede de preparation de composes analgesiques

Info

Publication number
BE788478A
BE788478A BE788478DA BE788478A BE 788478 A BE788478 A BE 788478A BE 788478D A BE788478D A BE 788478DA BE 788478 A BE788478 A BE 788478A
Authority
BE
Belgium
Prior art keywords
analgesic compounds
preparing analgesic
preparing
compounds
analgesic
Prior art date
Application number
Other languages
English (en)
French (fr)
Inventor
I J Pachter
B R Belleau
I Monkovic
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Publication date
Publication of BE788478A publication Critical patent/BE788478A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BE788478D 1971-09-08 Procede de preparation de composes analgesiques BE788478A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17883771A 1971-09-08 1971-09-08
US00217633A US3819635A (en) 1971-09-08 1972-01-13 14-hydroxymorphinan derivatives

Publications (1)

Publication Number Publication Date
BE788478A true BE788478A (fr) 1973-03-06

Family

ID=26874723

Family Applications (1)

Application Number Title Priority Date Filing Date
BE788478D BE788478A (fr) 1971-09-08 Procede de preparation de composes analgesiques

Country Status (19)

Country Link
US (1) US3819635A (de)
JP (1) JPS5310596B2 (de)
AU (1) AU470102B2 (de)
BE (1) BE788478A (de)
CA (1) CA999578A (de)
CH (1) CH590845A5 (de)
CY (1) CY980A (de)
DD (1) DD100255A5 (de)
DE (3) DE2265256C2 (de)
DK (1) DK141624B (de)
FR (1) FR2154481B1 (de)
GB (2) GB1412129A (de)
HK (1) HK2679A (de)
IE (2) IE36687B1 (de)
KE (1) KE2911A (de)
MY (1) MY7900027A (de)
NL (1) NL162072C (de)
SE (2) SE398877B (de)
YU (1) YU45099B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3910920A (en) * 1973-11-07 1975-10-07 Bristol Myers Co 3,14,17-Substituted-6,7-tetramethylenemorphinans
US3980641A (en) * 1975-07-31 1976-09-14 Bristol-Myers Company Process for the preparation of 14-hydroxymorphinans
US4017497A (en) * 1975-11-18 1977-04-12 Bristol-Myers Company Process for the preparation of 14-hydroxymorphinan derivatives
US4058531A (en) * 1976-03-23 1977-11-15 Bristol-Myers Company Process for the preparation of 14-hydroxymorphinan derivatives
JPS52136176A (en) * 1976-03-23 1977-11-14 Bristol Myers Co Method of improving 144hydroxymorphinan derivatives
US4139534A (en) * 1977-02-17 1979-02-13 Bristol-Myers Company Process for the preparation of 14-hydroxymorphinan derivatives
US4052389A (en) * 1976-03-23 1977-10-04 Bristol-Myers Company Derivatives of 9,10-dihydroxy-1-(p-alkoxybenzyl)-perhydroisoquinoline oxazine-3-one
GB1587831A (en) * 1977-03-23 1981-04-08 Reckitt & Colmann Prod Ltd Morphine derivatives
GB1593191A (en) * 1977-03-23 1981-07-15 Reckitt & Colmann Prod Ltd Derivatives of morphine
US4115389A (en) * 1977-05-02 1978-09-19 Bristol-Myers Company Process of N-demethylating (-)-1-(p-methoxybenzyl)-2-methyl-1,2,3,4,5,6,7,8-octahydroisoquinoline
US4338320A (en) * 1978-11-15 1982-07-06 The Board Of Regents Of The University Of Nebraska Esters of 6'-hydroxycinchonine, and a method of treating arrythmia with them
US4228285A (en) * 1979-02-28 1980-10-14 Bristol-Myers Company 14-Hydroxy-6-oxamorphinans and 14-hydroxy-6-oxaisomorphinans
US4272540A (en) * 1979-04-24 1981-06-09 Sisa, Incorporated 14-Methoxymorphinan-6-one compounds and therapeutic methods of treating pain and drug dependence with them
US4322427A (en) * 1981-04-16 1982-03-30 Bristol-Myers Company Analgetic compositions and methods of use
EP0661283B1 (de) * 1993-07-19 1998-10-21 Toray Industries, Inc. Wirkstoff zum schutze von gehirnzellen
CA2143864C (en) * 1993-07-23 2006-01-24 Hiroshi Nagase Morphinan derivatives and pharmaceutical use thereof
CZ281174B6 (cs) * 1993-08-13 1996-07-17 Galena, A.S. Způsob přípravy 3,14ß-dihydroxy-17-normorfinanu
ATE265846T1 (de) 1998-02-25 2004-05-15 Abbott Lab Butorphanol enthaltende formulierungen mit verzögerter freisetzung
US20040167164A1 (en) * 1998-05-05 2004-08-26 Jose Pozuelo Compositions and methods for treating particular chemical addictions and mental illnesses
US7501433B2 (en) * 2002-05-17 2009-03-10 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
EP2987788A1 (de) 2002-05-17 2016-02-24 Taiwanj Pharmaceuticals Co., Ltd. Opioid und opioidähnliche verbindungen und verwendung davon
US7923454B2 (en) 2002-05-17 2011-04-12 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US8017622B2 (en) 2003-05-16 2011-09-13 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
CN103073496B (zh) * 2013-02-18 2015-08-26 苏州立新制药有限公司 右美沙芬的制备方法
KR102102513B1 (ko) 2014-10-14 2020-04-20 히사미쓰 세이야꾸 가부시키가이샤 첩부제

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3166559A (en) * 1965-01-19 J-lower alkoxy-x-phenyloxy-ix-hydroxy-
GB1028407A (en) * 1962-04-06 1966-05-04 Shionogi & Co Improvements in or relating to morphinan derivatives and their preparation
FR1362540A (fr) * 1963-04-05 1964-06-05 Shionogi & Co Dérivés n substitués du morphinane et leur production

Also Published As

Publication number Publication date
DE2265255C2 (de) 1986-06-05
NL7212176A (de) 1973-03-12
IE36688B1 (en) 1977-02-02
SE403286B (sv) 1978-08-07
FR2154481A1 (de) 1973-05-11
IE36687L (en) 1973-03-08
DE2265256C2 (de) 1985-10-24
HK2679A (en) 1979-01-19
CY980A (en) 1979-03-23
NL162072C (nl) 1980-04-15
GB1412129A (en) 1975-10-29
DE2243961C2 (de) 1988-07-21
SE7506292L (sv) 1975-06-02
AU470102B2 (en) 1976-03-04
SE398877B (sv) 1978-01-23
CA999578A (en) 1976-11-09
NL162072B (nl) 1979-11-15
DE2265255A1 (de) 1977-01-27
KE2911A (en) 1979-01-26
DE2243961A1 (de) 1973-04-05
US3819635A (en) 1974-06-25
DD100255A5 (de) 1973-09-12
YU45099B (sh) 1992-07-20
DK141624B (da) 1980-05-12
IE36687B1 (en) 1977-02-02
DE2265256A1 (de) 1977-01-27
JPS5310596B2 (de) 1978-04-14
FR2154481B1 (de) 1976-04-23
MY7900027A (en) 1979-12-31
AU4622872A (en) 1974-03-07
CH590845A5 (de) 1977-08-31
GB1412130A (en) 1975-10-29
JPS4834864A (de) 1973-05-22
DK141624C (de) 1980-10-13
YU227772A (en) 1982-02-28

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: BRISTOL MYERS CY

Effective date: 19920906