YU42369B - Process for preparing new alpha-substituted benzhydrol derivatives - Google Patents

Process for preparing new alpha-substituted benzhydrol derivatives

Info

Publication number
YU42369B
YU42369B YU3164/80A YU316480A YU42369B YU 42369 B YU42369 B YU 42369B YU 3164/80 A YU3164/80 A YU 3164/80A YU 316480 A YU316480 A YU 316480A YU 42369 B YU42369 B YU 42369B
Authority
YU
Yugoslavia
Prior art keywords
preparing new
new alpha
benzhydrol derivatives
substituted
substituted benzhydrol
Prior art date
Application number
YU3164/80A
Other languages
English (en)
Other versions
YU316480A (en
Inventor
E Toth
J Toerley
S Szeberenyi
E Palosi
L Szporny
S Goeroeg
S Meszaros
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of YU316480A publication Critical patent/YU316480A/xx
Publication of YU42369B publication Critical patent/YU42369B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/30—Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
YU3164/80A 1973-08-15 1980-12-15 Process for preparing new alpha-substituted benzhydrol derivatives YU42369B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HURI521A HU168432B (xx) 1973-08-15 1973-08-15

Publications (2)

Publication Number Publication Date
YU316480A YU316480A (en) 1982-02-28
YU42369B true YU42369B (en) 1988-08-31

Family

ID=11000932

Family Applications (3)

Application Number Title Priority Date Filing Date
YU2226/74A YU37300B (en) 1973-08-15 1974-08-14 Process for preparing new substituted benzhydrol derivatives
YU3163/80A YU42368B (en) 1973-08-15 1980-12-15 Process for preparing new benzhydrol derivatives
YU3164/80A YU42369B (en) 1973-08-15 1980-12-15 Process for preparing new alpha-substituted benzhydrol derivatives

Family Applications Before (2)

Application Number Title Priority Date Filing Date
YU2226/74A YU37300B (en) 1973-08-15 1974-08-14 Process for preparing new substituted benzhydrol derivatives
YU3163/80A YU42368B (en) 1973-08-15 1980-12-15 Process for preparing new benzhydrol derivatives

Country Status (24)

Country Link
US (1) US4039589A (xx)
JP (1) JPS525507B2 (xx)
AT (3) AT336595B (xx)
BE (1) BE818801A (xx)
BG (3) BG24049A3 (xx)
CA (1) CA1037479A (xx)
CH (3) CH609958A5 (xx)
CS (3) CS190434B2 (xx)
DD (1) DD113742A5 (xx)
DE (1) DE2438399C3 (xx)
DK (1) DK165059C (xx)
FI (2) FI63012C (xx)
FR (1) FR2240725B1 (xx)
GB (1) GB1478185A (xx)
HK (1) HK81879A (xx)
HU (1) HU168432B (xx)
IL (1) IL45431A (xx)
KE (1) KE3006A (xx)
MX (1) MX5768E (xx)
NL (1) NL183718C (xx)
PL (2) PL96704B1 (xx)
SE (1) SE423537B (xx)
SU (2) SU660586A3 (xx)
YU (3) YU37300B (xx)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE11770T1 (de) * 1981-12-14 1985-02-15 Sandoz-Erfindungen Verwaltungsgesellschaft M.B.H. N,n,disubstituierte alkenamide und phenylaldenamide, verfahren zu deren herstellung und deren verwendung als pharmazeutika.
HU186656B (en) * 1982-12-28 1985-09-30 Richter Gedeon Vegyeszet Process for producing new benzhydryl-piperazine derivatives, acid additionak salts and pharmaceutical compositions containing them
HU190434B (en) * 1982-12-28 1986-09-29 Richter Gedeon Vegyeszeti Gyar,Rt,Hu Process for the production of 3-trifluor-methyl- and 2,5-dimethyl-4'-hydroxy-alpha-ethyl-benzhydrol,as well as of therapeutci preparations containing them
HU187208B (en) * 1982-12-28 1985-11-28 Richter Gedeon Vegyeszet Process for production of new dialcil-amino-alcoxi-benzoalcohole derivates, their acid additional and quaterner soils and medical preparates consisting of them
HU187205B (en) * 1982-12-28 1985-11-28 Richter Gedeon Vegyeszet Process for preparing new derivatives of amni-ethoxy-benzyl-alcohol and salts thereof further pharmaceutical compositions containing such compounds
HU186655B (en) * 1982-12-28 1985-09-30 Richter Gedeon Vegyeszet Process for producing new piperidine derivatives, acid additional salts and quaternary salts and pharmaceutical compositions containing them
HU187204B (en) * 1982-12-28 1985-11-28 Richter Gedeon Vegyeszet Process for producing new diethyl-amino-alkoxy-benzhydrol derivatives, acid additional salts, and quaternary salts and pharmaceutical compositions contatining them
HU190053B (en) * 1982-12-28 1986-08-28 Richter Gedeon Vegyeszeti Gyar Rt,Hu Process for the production of new 1,1-diphenyl-propanol-derivatives, as well as of therapeutic preparations containing them
HU189209B (en) * 1982-12-28 1986-06-30 Richter Gedeon Vegyeszeti Gyar Rt,Hu Process for production of new 1-/amino-alkoxi-phenil/-1-phenil propanols, of their acide additioned and quaternary salts and medical preparatives consisting of such compounds
HU191966B (en) * 1984-10-25 1987-04-28 Richter Gedeon Vegyeszet Fodder additive and process for producing same
WO1999055318A1 (en) * 1998-04-29 1999-11-04 Choongwae Pharm. Co., Ltd. Dihydroxyphenyl derivatives for hepatoprotection and treatment of liver diseases
US6693126B2 (en) 2000-10-27 2004-02-17 Choongwae Pharm. Co., Ltd. Dihydroxyphenyl derivatives for hepatoprotection and treatment of liver diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2430586A (en) * 1945-07-26 1947-11-11 Sherwin Williams Co Dihalophenyl alkyl carbinol pesticides
US3106587A (en) * 1959-12-17 1963-10-08 Koninklijke Pharma Fab Nv 2-trifluoromethyldi-phenylcarbinol
US3169962A (en) * 1963-02-28 1965-02-16 Olin Mathieson Benzhydryl ethers of 10-(hydroxyethylpiperazinopropyl) phenothiazines
FR1507192A (fr) * 1966-08-26 1967-12-29 Roussel Uclaf Nouvelles aryl allylsulfones et procédé de préparation

Also Published As

Publication number Publication date
JPS525507B2 (xx) 1977-02-14
YU222674A (en) 1983-04-27
YU316380A (en) 1982-02-28
ATA208576A (de) 1977-02-15
CA1037479A (en) 1978-08-29
NL183718C (nl) 1989-01-02
FI63012C (fi) 1983-04-11
AT339290B (de) 1977-10-10
SE423537B (sv) 1982-05-10
BE818801A (fr) 1974-12-02
DE2438399A1 (de) 1975-02-20
CS190450B2 (en) 1979-05-31
FR2240725B1 (xx) 1978-07-21
YU316480A (en) 1982-02-28
NL7410904A (nl) 1975-02-18
FI73961C (fi) 1987-12-10
CS190434B2 (en) 1979-05-31
ATA208476A (de) 1977-05-15
ATA656174A (de) 1976-09-15
CH615410A5 (en) 1980-01-31
BG24225A3 (en) 1978-01-10
US4039589A (en) 1977-08-02
SE7410243L (xx) 1975-02-17
IL45431A0 (en) 1974-11-29
DD113742A5 (xx) 1975-06-20
DK165059B (da) 1992-10-05
MX5768E (es) 1984-06-29
FR2240725A1 (xx) 1975-03-14
JPS5062959A (xx) 1975-05-29
BG25068A3 (en) 1978-07-12
FI63012B (fi) 1982-12-31
SU649306A3 (ru) 1979-02-25
DK165059C (da) 1993-02-22
FI240174A (xx) 1975-02-16
KE3006A (en) 1979-12-14
PL95766B1 (pl) 1977-11-30
DE2438399B2 (de) 1978-10-12
FI73961B (fi) 1987-08-31
SU660586A3 (ru) 1979-04-30
YU42368B (en) 1988-08-31
CS190449B2 (en) 1979-05-31
AU7215974A (en) 1976-02-12
NL183718B (nl) 1988-08-01
CH609958A5 (xx) 1979-03-30
HK81879A (en) 1979-12-07
CH615409A5 (xx) 1980-01-31
PL96704B1 (pl) 1978-01-31
FI821209L (fi) 1982-04-06
FI821209A0 (fi) 1982-04-06
BG24049A3 (en) 1977-12-15
DK433574A (xx) 1975-04-28
DE2438399C3 (de) 1979-06-13
IL45431A (en) 1978-10-31
HU168432B (xx) 1976-04-28
GB1478185A (en) 1977-06-29
YU37300B (en) 1984-08-31
AT340908B (de) 1978-01-10
AT336595B (de) 1977-05-10

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