YU35698A - Oksa- i tia- diazol antagonisti muskarinskog receptora - Google Patents

Oksa- i tia- diazol antagonisti muskarinskog receptora

Info

Publication number
YU35698A
YU35698A YU35698A YU35698A YU35698A YU 35698 A YU35698 A YU 35698A YU 35698 A YU35698 A YU 35698A YU 35698 A YU35698 A YU 35698A YU 35698 A YU35698 A YU 35698A
Authority
YU
Yugoslavia
Prior art keywords
alkyl
receptor antagonists
nuscarinic
diazol
tia
Prior art date
Application number
YU35698A
Other languages
English (en)
Inventor
Alexander Roderick Mackenzie
Anthony Wood
Robert John Bass
Original Assignee
Pfizer Research And Development Company N.V./S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Research And Development Company N.V./S.A. filed Critical Pfizer Research And Development Company N.V./S.A.
Publication of YU35698A publication Critical patent/YU35698A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Jedinjenje formule (I) gde R1 je C1-C6 alkil, halo (C1-C6 alkil), C3-C7 cikloalkil, C2-C6 alkinil, hidroksi-(C2-C6 alkinil), aril, aril-(C1-C4 alkil), heteroaril ili heteroaril-(C1-C4 alkil); R2 je H ili C1-C4 alkil; R3 je aril, heteroaril, 2,3-dihidrobenzofuranil ili C4-C7 cikloalkil; X je O ili S; i Y je direktna veza, -CH2-, -(CH2)2 ili -CH2O-; ili njihove farmaceutski prihvatljive soli. Jedinjenja su antagonisti muskarinskog receptora korisni u tretiranju, na primer, iritirajućeg crevnog sindroma i nekontrolisanog mokrenja. Jedinjenja su takodje korisna kao pojačivači spoznaje.
YU35698A 1996-02-22 1998-08-21 Oksa- i tia- diazol antagonisti muskarinskog receptora YU35698A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9603755.1A GB9603755D0 (en) 1996-02-22 1996-02-22 Therapeutic agents

Publications (1)

Publication Number Publication Date
YU35698A true YU35698A (sh) 1999-07-28

Family

ID=10789217

Family Applications (1)

Application Number Title Priority Date Filing Date
YU35698A YU35698A (sh) 1996-02-22 1998-08-21 Oksa- i tia- diazol antagonisti muskarinskog receptora

Country Status (43)

Country Link
US (1) US5977142A (sh)
EP (1) EP0885218B1 (sh)
JP (1) JP3148252B2 (sh)
KR (1) KR100315934B1 (sh)
CN (1) CN1089340C (sh)
AP (1) AP751A (sh)
AR (1) AR005916A1 (sh)
AT (1) ATE200899T1 (sh)
AU (1) AU712230B2 (sh)
BG (2) BG102699A (sh)
BR (1) BR9707733A (sh)
CA (1) CA2247164C (sh)
CO (1) CO4650040A1 (sh)
CZ (1) CZ292650B6 (sh)
DE (1) DE69704701T2 (sh)
DK (1) DK0885218T3 (sh)
DZ (1) DZ2181A1 (sh)
ES (1) ES2156357T3 (sh)
GB (1) GB9603755D0 (sh)
GR (1) GR3036032T3 (sh)
HK (1) HK1018274A1 (sh)
HN (1) HN1997000020A (sh)
HR (1) HRP970098B1 (sh)
HU (1) HUP9900501A3 (sh)
ID (1) ID16642A (sh)
IL (1) IL125413A (sh)
IS (1) IS4803A (sh)
MY (1) MY129729A (sh)
NO (1) NO313414B1 (sh)
NZ (1) NZ331039A (sh)
OA (1) OA10838A (sh)
PE (1) PE42798A1 (sh)
PL (1) PL186879B1 (sh)
PT (1) PT885218E (sh)
RU (1) RU2162848C2 (sh)
SK (1) SK283461B6 (sh)
TN (1) TNSN97039A1 (sh)
TR (1) TR199801644T2 (sh)
TW (1) TW492961B (sh)
UA (1) UA61068C2 (sh)
WO (1) WO1997030994A1 (sh)
YU (1) YU35698A (sh)
ZA (1) ZA971513B (sh)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6107313A (en) * 1998-10-02 2000-08-22 Combichem, Inc. Dopamine receptor antagonists
GB0510141D0 (en) * 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B3
GB0510139D0 (en) * 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B1
GB0516313D0 (en) 2005-08-08 2005-09-14 Argenta Discovery Ltd Azole derivatives and their uses
WO2008017827A2 (en) * 2006-08-08 2008-02-14 Argenta Discovery Limited Azole and thiazole derivatives and their uses
WO2008023157A1 (en) * 2006-08-21 2008-02-28 Argenta Discovery Limited Nitrogen containing heterocyclic compounds useful as m3-receptor modulators
WO2008096093A1 (en) * 2007-02-06 2008-08-14 Argenta Discovery Ltd. Oxazole and thiazole derivatives and their uses
GB0702382D0 (en) * 2007-02-07 2007-03-21 Argenta Discovery Ltd New salt
GB0702416D0 (en) * 2007-02-07 2007-03-21 Argenta Discovery Ltd New combination
GB0702414D0 (en) * 2007-02-07 2007-03-21 Argenta Discovery Ltd Oxazole and thiazole derivatives and their uses 2
GB0702385D0 (en) * 2007-02-07 2007-03-21 Argenta Discovery Ltd New combination
US7846955B2 (en) * 2007-02-07 2010-12-07 Astrazeneca Ab Salt
CN101657452A (zh) * 2007-02-15 2010-02-24 阿金塔探索有限公司 作为m3毒蕈碱性受体的杂环衍生物
WO2009098453A1 (en) * 2008-02-06 2009-08-13 Astrazeneca Ab Azonia bicycloalkanes as m3 muscarinic acetylcholin receptor antagonists
US8263623B2 (en) 2008-07-11 2012-09-11 Pfizer Inc. Triazol derivatives useful for the treatment of diseases
WO2010018352A1 (en) * 2008-08-12 2010-02-18 Argenta Discovery Limited Heterocyclic compounds used in the treatment of diseases where enhanced m3 receptor activation is implicated
JP2014065387A (ja) * 2012-09-25 2014-04-17 Showa Corp 自動二輪車の車高調整装置

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ219646A (en) * 1986-03-27 1990-10-26 Merck Sharp & Dohme Oxadiazole derivatives of azacyclics for treating cns disorders
IL88846A0 (en) * 1988-01-08 1989-07-31 Merck Sharp & Dohme Lipophilic oxadiazoles,their preparation and pharmaceutical compositions containing them
US5043345A (en) * 1989-02-22 1991-08-27 Novo Nordisk A/S Piperidine compounds and their preparation and use
WO1993013083A1 (en) * 1991-12-31 1993-07-08 Fujisawa Pharmaceutical Co., Ltd. Oxadiazole derivatives having acetylcholinesterase-inhibitory and muscarinic agonist activity
TW360653B (en) * 1995-03-01 1999-06-11 Janssen Pharmaceutica Nv A oxadiazole compound having colon motility stimulating properties, its preparation process and its pharmaceutical composition

Also Published As

Publication number Publication date
NO983871D0 (no) 1998-08-21
US5977142A (en) 1999-11-02
DZ2181A1 (fr) 2002-12-01
AR005916A1 (es) 1999-07-21
AP751A (en) 1999-07-12
ZA971513B (en) 1998-08-21
SK283461B6 (sk) 2003-08-05
DE69704701D1 (de) 2001-06-07
IL125413A0 (en) 1999-03-12
IS4803A (is) 1998-07-21
PT885218E (pt) 2001-08-30
TW492961B (en) 2002-07-01
HUP9900501A3 (en) 2001-02-28
KR100315934B1 (ko) 2002-03-21
JP3148252B2 (ja) 2001-03-19
MY129729A (en) 2007-04-30
OA10838A (en) 2001-08-13
CZ292650B6 (cs) 2003-11-12
CO4650040A1 (es) 1998-09-03
HK1018274A1 (en) 1999-12-17
BR9707733A (pt) 1999-07-27
AU1601497A (en) 1997-09-10
NO313414B1 (no) 2002-09-30
DE69704701T2 (de) 2001-08-16
ATE200899T1 (de) 2001-05-15
HUP9900501A2 (hu) 1999-06-28
GR3036032T3 (en) 2001-09-28
CA2247164A1 (en) 1997-08-28
HRP970098A2 (en) 1999-04-30
EP0885218A1 (en) 1998-12-23
CN1211981A (zh) 1999-03-24
AU712230B2 (en) 1999-11-04
SK112398A3 (en) 2000-04-10
AP9700930A0 (en) 1997-04-30
HN1997000020A (es) 1997-06-05
HRP970098B1 (en) 2001-12-31
ES2156357T3 (es) 2001-06-16
PL186879B1 (pl) 2004-03-31
JPH11504051A (ja) 1999-04-06
CZ267898A3 (cs) 1999-08-11
EP0885218B1 (en) 2001-05-02
NO983871L (no) 1998-08-21
GB9603755D0 (en) 1996-04-24
TR199801644T2 (xx) 1998-11-23
RU2162848C2 (ru) 2001-02-10
CN1089340C (zh) 2002-08-21
KR19990087143A (ko) 1999-12-15
NZ331039A (en) 1999-10-28
ID16642A (id) 1997-10-23
DK0885218T3 (da) 2001-05-28
BG63971B1 (bg) 2003-08-29
CA2247164C (en) 2004-11-16
PE42798A1 (es) 1998-08-18
IL125413A (en) 2002-09-12
UA61068C2 (en) 2003-11-17
TNSN97039A1 (fr) 2005-03-15
WO1997030994A1 (en) 1997-08-28
BG102699A (en) 1999-09-30
PL328633A1 (en) 1999-02-15

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