YU205590A - Amidi imidazo (4,5-b)hinolinoloksi alkanovih kiselina sa poboljšanom rastvorljivošću u vodi i postupak za dobijanje - Google Patents

Amidi imidazo (4,5-b)hinolinoloksi alkanovih kiselina sa poboljšanom rastvorljivošću u vodi i postupak za dobijanje

Info

Publication number
YU205590A
YU205590A YU205590A YU205590A YU205590A YU 205590 A YU205590 A YU 205590A YU 205590 A YU205590 A YU 205590A YU 205590 A YU205590 A YU 205590A YU 205590 A YU205590 A YU 205590A
Authority
YU
Yugoslavia
Prior art keywords
imidazo
4alkyl
amidi
water solubility
improved water
Prior art date
Application number
YU205590A
Other languages
English (en)
Inventor
N. Meanwell
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of YU205590A publication Critical patent/YU205590A/sh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

AMIDI IMIDAZO (4,5-B)HINOLINOLOKSI ALKANOVIH KISELINA SA POBOLJŠANOM RASTVORLJIVOŠĆU U VODI I POSTUPAK ZA DOBIJANJE, Opisana je nova serija 2,3-dihidro-2-okso-1H-imidazo/4,5-b/ hinolinoloksi alkanovih kiselina sa pojačanom rastvorljivošću u vodi, formule: u kojoj n ima vrednost od 3 do 5; R1 je C1-4alkil; R2 je vodonii; R3 je 1-piperidiniletil, 1-benzilpiperidin-4-il, 4-(1-piperidinil)piperidin, (1-C1-4alkil-2-pirolidinil)C1-4alkil, ili 3-hinuklidinil; ili R2 i R3, zajedno sa azotovim atomom za koji su vezani, grade grupu 4-R4-piperazin-1-il, gde je R4C1-7alkil, C3-7alkoksietil, piridinil, piramidinil, tetrahidropiranilmetil, tienilmetil, ciklo (C5-7)alkil-(CH2)n gde je n 0 ili 1 osim što u slučaju cikloheptila n može da bude samo 0, benzil, 4fluorobenzil, 3-trifluorometilbenzil, 4-(C1-4)alkoksibenzil. Jedinjenja iz pronalaska su inhibitori ciklične AMP fosfodiesteraze i naročito su korisna kao inhibitori agregacije krvnih pločica i/ili kao kardiotonička sredstva. Opisan je i postupak za dobijanje jedinjenja formule (I) i njihovih farmaceutski prihvatljivih soli.
YU205590A 1989-11-01 1990-10-30 Amidi imidazo (4,5-b)hinolinoloksi alkanovih kiselina sa poboljšanom rastvorljivošću u vodi i postupak za dobijanje YU205590A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/430,228 US4943573A (en) 1989-11-01 1989-11-01 Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility

Publications (1)

Publication Number Publication Date
YU205590A true YU205590A (sh) 1992-09-07

Family

ID=23706624

Family Applications (1)

Application Number Title Priority Date Filing Date
YU205590A YU205590A (sh) 1989-11-01 1990-10-30 Amidi imidazo (4,5-b)hinolinoloksi alkanovih kiselina sa poboljšanom rastvorljivošću u vodi i postupak za dobijanje

Country Status (20)

Country Link
US (1) US4943573A (sh)
EP (1) EP0426180A3 (sh)
JP (1) JPH03169880A (sh)
KR (1) KR910009705A (sh)
CN (1) CN1025999C (sh)
AU (1) AU639033B2 (sh)
CA (1) CA2027935A1 (sh)
EG (1) EG19372A (sh)
FI (1) FI92697C (sh)
HU (1) HU209305B (sh)
IE (1) IE61579B1 (sh)
IL (1) IL96167A (sh)
MY (1) MY105308A (sh)
NO (1) NO175531C (sh)
NZ (1) NZ235868A (sh)
OA (1) OA09323A (sh)
PT (1) PT95765A (sh)
RU (1) RU2041210C1 (sh)
YU (1) YU205590A (sh)
ZA (1) ZA908725B (sh)

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Also Published As

Publication number Publication date
US4943573A (en) 1990-07-24
EP0426180A3 (en) 1992-01-08
NO904689D0 (no) 1990-10-30
NO175531B (no) 1994-07-18
HU906977D0 (en) 1991-05-28
KR910009705A (ko) 1991-06-28
EP0426180A2 (en) 1991-05-08
OA09323A (en) 1992-09-15
RU2041210C1 (ru) 1995-08-09
AU6567990A (en) 1991-05-23
HUT56102A (en) 1991-07-29
IL96167A (en) 1994-11-11
NO175531C (no) 1994-10-26
CA2027935A1 (en) 1991-05-02
FI92697C (fi) 1994-12-27
FI92697B (fi) 1994-09-15
FI905326A0 (fi) 1990-10-29
NO904689L (no) 1991-05-02
EG19372A (en) 1994-12-30
IL96167A0 (en) 1991-07-18
IE903923A1 (en) 1991-05-08
ZA908725B (en) 1991-07-31
MY105308A (en) 1994-09-30
HU209305B (en) 1994-04-28
CN1051359A (zh) 1991-05-15
NZ235868A (en) 1993-12-23
CN1025999C (zh) 1994-09-28
AU639033B2 (en) 1993-07-15
JPH03169880A (ja) 1991-07-23
PT95765A (pt) 1991-09-13
IE61579B1 (en) 1994-11-16

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