YU128591A - Postupak za dobijanje 6-(substituiranih aminopropilnih) derivata forskolina - Google Patents
Postupak za dobijanje 6-(substituiranih aminopropilnih) derivata forskolinaInfo
- Publication number
- YU128591A YU128591A YU128591A YU128591A YU128591A YU 128591 A YU128591 A YU 128591A YU 128591 A YU128591 A YU 128591A YU 128591 A YU128591 A YU 128591A YU 128591 A YU128591 A YU 128591A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- derivatives
- forscoline
- procedure
- obtaining
- substituted aminopropyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
POSTUPAK ZA DOBIJANJE 6-(SUBSTITUIRANIH AMINOPROPILNIH) DERIVATOVFORSKOLINA, postupak za pripremu 6beta(subst.aino)propiloksiforskolinskih derivata formule I pri čemu R1 i R2 predstavljaju vodonik, alkil, aril, aralkil ili dialkilaminoalkil; ili R1 i R2 zajedno sa azotom za koga su vezani, čine heterocikl, koji može da sadrži dodatni heteroatom, kao N, O, S, i moguće ga je u datom primeru substituisan na jednom ili više položaja sa alkilom, alkoksi, hidroksilom, halogenom ili arilom, i njihovih farmaceutso prihvatljivih soli a) prevodjenjem forskolina (jedinjenje sa formulom I sa OH u položaju 6) sa acetonom u prisustvu vodonikhlorida, u 1,9-izopropilenski derivat, b) taj derivat obradimo alkalijom u alkanolu da bi dobili 7-deacetilni derivat, c) taj derivat obradimo sa betahalopropionilhalidom u prisustvu organske baze, pri čemu nastaje 1,9-izopropilidenski derivat 7beta-akriloiloksi-7-deactil forskolina, d) taj derivat obradimo alkalijom, pri čemu nastaje 1,9-0-izopropolidienski derivat 6beta-akriloiloksi-7-deacetil forskolina, e) koga prevedemo u 7beta acetonski derivat, f) koga prevedemo aminom formule u kojoj R1 i R2 imaju gore navedeno značenje u (3-substituisani amino) propioniloksi derivat u položaju 6, i g) iz dobijenog jedinjenja odstranimo zaštitu u položajima 1,9, pri čemu dobijamo jedinjenje formule I, h) koje prevedemo po želji u farmaceutsko prihvatljivu so, pri čemu možemo zameniti redosled postupka (e) i (f) a takodje postupke (f) i (g).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP90114124 | 1990-07-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU128591A true YU128591A (sh) | 1994-09-09 |
| YU48634B YU48634B (sh) | 1999-03-04 |
Family
ID=8204249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU128591A YU48634B (sh) | 1990-07-24 | 1991-07-22 | Postupak za dobijanje 6-(supstituisanih aminopropionil) derivata forskolina i jedinjenja koja se dobijaju ovim postupkom |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5869523A (sh) |
| EP (1) | EP0468445B1 (sh) |
| JP (1) | JPH04279577A (sh) |
| KR (1) | KR0173317B1 (sh) |
| CN (1) | CN1033583C (sh) |
| AT (1) | ATE132863T1 (sh) |
| AU (1) | AU642754B2 (sh) |
| CA (1) | CA2047617A1 (sh) |
| CZ (1) | CZ281393B6 (sh) |
| DE (1) | DE69116251T2 (sh) |
| DK (1) | DK0468445T3 (sh) |
| ES (1) | ES2082890T3 (sh) |
| FI (1) | FI913506A (sh) |
| GR (1) | GR3018642T3 (sh) |
| HU (1) | HU208966B (sh) |
| IE (1) | IE74140B1 (sh) |
| IL (1) | IL98914A (sh) |
| MX (1) | MX9100345A (sh) |
| MY (1) | MY106512A (sh) |
| PL (1) | PL167626B1 (sh) |
| RU (1) | RU2045523C1 (sh) |
| YU (1) | YU48634B (sh) |
| ZA (1) | ZA915763B (sh) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2034840C1 (ru) * | 1990-07-24 | 1995-05-10 | Хехст АГ | СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ 6-бета-(3-ЗАМЕЩЕННОГО АМИНО)-ПРОПИОНИЛОКСИ-7-ДИАЦЕТИЛФОРСКОЛИНА ИЛИ ИХ ФАРМАЦЕВТИЧЕСКИ ПРИЕМЛЕМЫХ СОЛЕЙ |
| PL170900B1 (pl) * | 1990-11-01 | 1997-02-28 | Nippon Kayaku Kk | Sposób wytwarzania 6-(3-dwumetyloaminopropionylo)-forskolinu PL PL PL |
| US7334636B2 (en) * | 2005-02-08 | 2008-02-26 | Halliburton Energy Services, Inc. | Methods of creating high-porosity propped fractures using reticulated foam |
| AU2019414693A1 (en) * | 2018-12-29 | 2021-08-12 | Shanghai Archeus Biotech Co., Ltd. | Immunosuppressive pharmaceutical composition and application thereof |
| CN117586217B (zh) * | 2024-01-17 | 2024-03-19 | 云南省药物研究所 | 一种基于国产毛喉鞘蕊花的佛司可林制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3623300A1 (de) * | 1986-07-11 | 1988-01-21 | Hoechst Ag | 7-acyloxy-6-aminoacyloxypolyoxylabdane, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| FR2614891B1 (fr) * | 1987-05-04 | 1991-05-24 | Roussel Uclaf | Nouveaux derives de la forskoline, leur procede de preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant ainsi que des intermediaires de leur procede de preparation |
| EP0447962A1 (en) * | 1990-03-17 | 1991-09-25 | Hoechst Aktiengesellschaft | Labdanes and process for their preparation |
| RU2034840C1 (ru) * | 1990-07-24 | 1995-05-10 | Хехст АГ | СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ 6-бета-(3-ЗАМЕЩЕННОГО АМИНО)-ПРОПИОНИЛОКСИ-7-ДИАЦЕТИЛФОРСКОЛИНА ИЛИ ИХ ФАРМАЦЕВТИЧЕСКИ ПРИЕМЛЕМЫХ СОЛЕЙ |
-
1991
- 1991-07-22 MY MYPI91001323A patent/MY106512A/en unknown
- 1991-07-22 US US07/733,641 patent/US5869523A/en not_active Expired - Fee Related
- 1991-07-22 YU YU128591A patent/YU48634B/sh unknown
- 1991-07-22 IL IL9891491A patent/IL98914A/xx active IP Right Grant
- 1991-07-22 RU SU915001102A patent/RU2045523C1/ru active
- 1991-07-22 FI FI913506A patent/FI913506A/fi unknown
- 1991-07-22 KR KR1019910012500A patent/KR0173317B1/ko not_active IP Right Cessation
- 1991-07-23 CN CN91105008A patent/CN1033583C/zh not_active Expired - Fee Related
- 1991-07-23 EP EP91112326A patent/EP0468445B1/en not_active Expired - Lifetime
- 1991-07-23 ZA ZA915763A patent/ZA915763B/xx unknown
- 1991-07-23 AT AT91112326T patent/ATE132863T1/de not_active IP Right Cessation
- 1991-07-23 MX MX9100345A patent/MX9100345A/es not_active IP Right Cessation
- 1991-07-23 IE IE259291A patent/IE74140B1/en not_active IP Right Cessation
- 1991-07-23 DE DE69116251T patent/DE69116251T2/de not_active Expired - Fee Related
- 1991-07-23 ES ES91112326T patent/ES2082890T3/es not_active Expired - Lifetime
- 1991-07-23 AU AU81208/91A patent/AU642754B2/en not_active Ceased
- 1991-07-23 JP JP3182431A patent/JPH04279577A/ja active Pending
- 1991-07-23 PL PL91291199A patent/PL167626B1/pl unknown
- 1991-07-23 CA CA002047617A patent/CA2047617A1/en not_active Abandoned
- 1991-07-23 DK DK91112326.3T patent/DK0468445T3/da active
- 1991-07-23 CZ CS912313A patent/CZ281393B6/cs unknown
- 1991-07-24 HU HU912489A patent/HU208966B/hu not_active IP Right Cessation
-
1996
- 1996-01-11 GR GR950403688T patent/GR3018642T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL98914A (en) | 1997-01-10 |
| DE69116251D1 (de) | 1996-02-22 |
| AU642754B2 (en) | 1993-10-28 |
| HU912489D0 (en) | 1991-12-30 |
| CN1058403A (zh) | 1992-02-05 |
| MX9100345A (es) | 1992-02-28 |
| CA2047617A1 (en) | 1992-01-25 |
| HU208966B (en) | 1994-02-28 |
| PL167626B1 (pl) | 1995-10-31 |
| DE69116251T2 (de) | 1996-07-04 |
| RU2045523C1 (ru) | 1995-10-10 |
| FI913506A0 (fi) | 1991-07-22 |
| ZA915763B (en) | 1992-04-29 |
| IE74140B1 (en) | 1997-07-02 |
| GR3018642T3 (en) | 1996-04-30 |
| PL291199A1 (en) | 1992-03-09 |
| YU48634B (sh) | 1999-03-04 |
| JPH04279577A (ja) | 1992-10-05 |
| DK0468445T3 (da) | 1996-05-20 |
| EP0468445B1 (en) | 1996-01-10 |
| EP0468445A1 (en) | 1992-01-29 |
| IE912592A1 (en) | 1992-01-29 |
| KR920002573A (ko) | 1992-02-28 |
| ATE132863T1 (de) | 1996-01-15 |
| MY106512A (en) | 1995-06-30 |
| US5869523A (en) | 1999-02-09 |
| CN1033583C (zh) | 1996-12-18 |
| FI913506A (fi) | 1992-01-25 |
| KR0173317B1 (ko) | 1999-02-01 |
| CS231391A3 (en) | 1992-02-19 |
| CZ281393B6 (cs) | 1996-09-11 |
| HUT58715A (en) | 1992-03-30 |
| AU8120891A (en) | 1992-07-02 |
| ES2082890T3 (es) | 1996-04-01 |
| IL98914A0 (en) | 1992-07-15 |
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