Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/63—Steroids; Derivatives thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
  • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
  • A61K8/9783—Angiosperms [Magnoliophyta]
  • A61K8/9789—Magnoliopsida [dicotyledons]
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin

Definitions

• the present invention relates to cosmetics in which oil-soluble ingredients such as oils and fragrances are solubilized in water.
• Cosmetics are applied to the skin etc. to enhance its appearance, but depending on the application, they may be required to be either transparent or opaque. For example, transparency is often required for cosmetics that improve the condition of the skin, such as lotions.
• the inventors have discovered that the transparency of oil-soluble drugs can be significantly improved by using a specific thickener.
• the present invention is based on this finding.
• the following inventions are provided.
• a cosmetic preparation comprising: (C) a nonionic surfactant; and (D) water, the cosmetic preparation having a viscosity of 10,000 Pa ⁇ s or less at 25°C.
• the lipophilic group of the component (A) is an aliphatic hydrocarbon group having 15 or more carbon atoms
• the hydrophilic group of the component (A) is a group containing a polyalkyleneoxy structure or a 2-acrylamide-2-methylsulfonic acid structure.
• the component (A) is The cosmetic preparation according to [1] or [2], which is a (PEG-240/decyltetradeceth-20/HDI) copolymer or a (ammonium acryloyldimethyltaurate beheneth-25 methacrylate) crosspolymer.
• the component (C) is polyoxyethylene phytosterol.
• the present invention provides a cosmetic that contains oil-soluble ingredients while providing excellent transparency and a pleasant feel when used.
• the cosmetic composition according to the present invention comprises: (A) a thickener having a lipophilic group and a hydrophilic group, (B) an oil-soluble drug; (C) a nonionic surfactant, and (D) water.
• the cosmetic composition has a viscosity of 10,000 Pa ⁇ s or less at 25° C., and is preferably a liquid cosmetic composition or a gel cosmetic composition. Each component will be described below.
• the cosmetic composition according to the present invention contains a specific thickener (hereinafter, sometimes referred to as component (A)).
• This thickener has a lipophilic group and a hydrophilic group.
• component (A) in the present invention also exerts a thickening effect.
• This thickening effect is produced by the association of lipophilic groups (hydrophobic groups) in the molecule with lipophilic groups in other molecules.
• Hydrocarbon groups exhibit this effect, but aliphatic hydrocarbon groups are preferred, and those containing 15 or more carbon atoms are particularly preferred.
• the hydrophilic group is an aliphatic hydrocarbon group having 15 or more carbon atoms
• the hydrophilic group is preferably a group containing a polyalkyleneoxy structure or a 2-acrylamide-2-methylsulfonic acid structure.
• the lipophilic group binds to an oil-soluble drug described below, and the hydrophilic group has an affinity for the surrounding water, so that an appropriate dispersion state can be formed.
• thickening agents include (PEG-240/decyltetradeceth-20/HDI) copolymer, or (ammonium acryloyldimethyltaurate methacrylate beheneth-25) crosspolymer.
• the content of component (A) is not particularly limited, but based on the total mass of the cosmetic, the content of component (B) is preferably 0.05 to 5 mass%, and more preferably 0.1 to 1 mass%.
• the cosmetic according to the present invention contains an oil-soluble drug (hereinafter, sometimes referred to as component (B)).
• Component (B) can be selected from any drug that is soluble in oil and is typically blended in pharmaceuticals, cosmetics, etc. Specific examples include whitening agents, anti-rough skin agents, UV absorbers, anti-inflammatory agents, vitamins, antioxidants, oils and fats, etc., and in the present invention, it is preferable to select one or more of these. Of these, it is preferable to use a whitening agent in the present invention.
• Lily of the valley is a herbal medicine made by drying the seeds of Oriental arborescens, which belongs to the Cupressaceae family.
• the lily of the valley extract used in the present invention is an oil-soluble component extracted from Oriental arborescens seeds using an organic solvent.
• Lily of the valley extract is commonly used in cosmetics, but is often used in cream-like cosmetics, and is often opaque, but in the present invention, it can be made into a transparent liquid or gel-like cosmetic.
• the content of component (B) is not particularly limited, but the present invention has the characteristic that transparency can be maintained even when a relatively large amount of component (B) is blended.
• the content of component (B) is preferably 0.01 to 3 mass%, and more preferably 0.1 to 1 mass%, based on the total mass of the cosmetic product.
• the cosmetic preparation according to the present invention contains a nonionic surfactant (hereinafter sometimes referred to as component (C)).
• component (C) can be selected from any of those normally used in pharmaceuticals, cosmetics, etc. This nonionic surfactant dissolves component (B) in water together with component (A), and serves to make the cosmetic preparation transparent.
• nonionic surfactants including polyoxyethylene fatty acid glyceryl, polyoxyethylene-methylpolysiloxane copolymer, fatty acid polyoxyethylene sorbitan, polyoxyethylene alkyl ether, maltitol hydroxy fatty alkyl ether, alkylated polysaccharide, alkyl glucoside, sucrose fatty acid ester, polyoxyethylene hydrogenated castor oil glyceryl, fatty acid alkanolamide, and sorbitan fatty acid ester, and can be used in the present invention, but polyoxyethylene phytosterol is particularly preferred in the present invention.
• Component (C) is known to have different polyoxyethylene addition moles, but in the present invention, polyoxyethylene phytosterols having an oxyethylene addition mole number of 5 to 50 moles can be preferably used. Specific examples include polyoxyethylene (5 moles) phytosterol, polyoxyethylene (10 moles) phytosterol, polyoxyethylene (20 moles) phytosterol, and polyoxyethylene (30 moles) phytosterol. Commercially available products include, for example, NIKKOL BPS-5, NIKKOL B-10, NIKKOL BPS-20, and NIKKOL BPS-30 (all manufactured by Nippon Surfactant Industries Co., Ltd.).
• component (C) is dissolved by components (A) and (C).
• the content of component (C) is preferably 0.05 to 1 mass%, and more preferably 0.1 to 0.8 mass%, based on the total mass of the cosmetic preparation.
• the ratio of the total amount of components (A) and (C) to the amount of component (B) [(A)+(C)]/(B) is preferably from 1.5 to 5, and more preferably from 1.8 to 3.5.
• the cosmetic preparation according to the present invention further contains water in addition to the above-mentioned components.
• water water used in cosmetics, quasi-drugs, etc. can be used, such as purified water, ion-exchanged water, tap water, etc.
• the cosmetic preparation of the present invention can contain optional components that are usually used in cosmetics and pharmaceuticals.
• the optional components include the following, and one or more of them can be contained as long as the effects of the present invention are achieved.
• the cosmetic composition according to the present invention may contain, for example, a moisturizing agent.
• moisturizing agents include propylene glycol, glycerin, 1,3-butylene glycol, xylitol, sorbitol, maltitol, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caronic acid, atelocollagen, cholesteryl-12-hydroxystearate, sodium lactate, bile salts, dl-pyrrolidone carboxylate, short-chain soluble collagen, Rosa robur extract, Achillea millefolium extract, and Melilot extract.
• the cosmetic composition according to the present invention may contain a pH adjuster to suppress irritation when applied to the skin and to improve the stability of the cosmetic composition.
• pH adjusters include buffers such as lactic acid-sodium lactate, citric acid-sodium citrate, and succinic acid-sodium succinate.
• vitamins include vitamins A, B1, B2, B6, C, E and their derivatives, pantothenic acid and its derivatives, biotin, etc.
• ingredients that can be added include, for example, lower alcohols (e.g., ethanol); sequestering agents (e.g., disodium ethylenediaminetetraacetate); antioxidants (tocopherol, sulfites, pyrosulfites, etc.); water-soluble polymers; sugar chains; preservatives (phenoxyethanol, ethylparaben, butylparaben, etc.); anti-inflammatory agents (e.g., glycyrrhizinic acid derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, zinc oxide, allantoin, etc.); haccinamide whitening agents other than nicotinamide (e.g., placenta extract, saxifrage extract, arbutin, etc.); various extracts (e.g., Phellodendron bark, Coptis japonica, Lithospermum root, Peony root, Swertia japon
• the cosmetic product according to the present invention is not particularly limited, but examples thereof include skin care cosmetics (e.g., lotion, beauty essence, etc.), cleansing agents (e.g., face wash, makeup remover, etc.), etc.
• the formulation may be, for example, a liquid or gel.
• the cosmetic composition according to the present invention has a viscosity measured at 25°C using a B-type rotational viscometer of 10,000 mPa ⁇ s or less, preferably 5000 mPa ⁇ s or less, and more preferably 1000 mPa ⁇ s or less.
• the cosmetic composition according to the present invention is preferably transparent.
• the L value is preferably 90 or more, more preferably 95 or more, and even more preferably 99 or more.
• the L value refers to a value that represents transparency when the transparency of purified water is set to 100 and no light transmission is set to 0. In other words, the closer the L value is to 100, the higher the transparency.
• the L value can be measured, for example, using a color difference meter (spectrophotometer SE7700 (manufactured by Nippon Denshoku Industries Co., Ltd., etc.). In the present invention, the L value refers to a value measured at 30°C.
• the cosmetic product according to the present invention can be manufactured according to conventional methods.
• Examples 1 to 7 and Comparative Examples 1 and 2 Cosmetics according to Examples 1 to 7 and Comparative Examples 1 and 2 were prepared according to the formulations shown in Table 1. The obtained cosmetics were all liquid, and all had a viscosity of 1000 mPa ⁇ s or less. The viscosity was measured using a B-type viscometer (25° C.).
• Preferred formulation examples for the lotion of the present invention are shown below.
• the blending amounts are expressed as mass %.

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• Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Public Health (AREA)
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• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
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• Birds (AREA)
• Dermatology (AREA)
• Engineering & Computer Science (AREA)
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• Mycology (AREA)
• Cosmetics (AREA)

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Citations (11)

• 2023
  • 2023-11-30 JP JP2024565729A patent/JPWO2024135283A1/ja active Pending
  • 2023-11-30 WO PCT/JP2023/043013 patent/WO2024135283A1/ja not_active Ceased
  • 2023-11-30 CN CN202380080503.1A patent/CN120225175A/zh active Pending

Patent Citations (11)

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