WO2024099337A1 - Dérivés de thiadiazolyle, compositions et utilisations associées - Google Patents

Dérivés de thiadiazolyle, compositions et utilisations associées Download PDF

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WO2024099337A1
WO2024099337A1 PCT/CN2023/130329 CN2023130329W WO2024099337A1 WO 2024099337 A1 WO2024099337 A1 WO 2024099337A1 CN 2023130329 W CN2023130329 W CN 2023130329W WO 2024099337 A1 WO2024099337 A1 WO 2024099337A1
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alkyl
independently
compound
certain embodiments
optionally substituted
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PCT/CN2023/130329
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Jincong Zhuo
Yao ZHANG
Wenlai Zhou
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Danatlas Pharmaceuticals Co., Ltd.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Definitions

  • the present disclosure relates to thiadiazolyl derivatives as PolQ inhibitors and pharmaceutical compositions thereof.
  • the present disclosure also relates to methods for preparing the thiadiazolyl derivatives and their uses in the treatment of a PolQ-mediated disease, e.g., cancer containing a DNA repair defect.
  • Double strand breaks can be repaired by one of three main pathways: homologous recombination (HR) , non-homologous end-joining (NHEJ) , and alternative NHEJ (alt-NHEJ) .
  • HR homologous recombination
  • NHEJ non-homologous end-joining
  • alt-NHEJ alternative NHEJ
  • An alt-NHEJ also known as microhomology-mediated end-joining (MMEJ) , is commonly considered as a "backup" DSB repair pathway when NHEJ or HR is compromised.
  • MMEJ microhomology-mediated end-joining
  • DDR DNA damage response
  • PRP poly (ADP-ribose) polymerase
  • DNA polymerase theta is a key protein involved in MMEJ. Kent et al. Nat. Struct. Mol. Biol. 2015, 22, 230-7; Mateos-Gomez et al. Nature 2015, 518, 254-7. PolQ is distinct among human DNA polymerases, comprising an N-terminal helicase domain (SF2 HEL308-type) and a C-terminal low-fidelity DNA polymerase domain (A-type) . Wood and D bountye, DNA Repair (Amst) . 2016, 44, 22-32.
  • PolQ can carry out error-prone DNA synthesis at DNA damage sites through the alt-NHEJ pathway. It has been shown that the helicase domain of PolQ mediates the removal of a replication (RPA) protein from single-stranded (ssDNA) ends and stimulates annealing. This anti-recombinase activity of PolQ promotes the alt-NHEJ pathway. In addition, the helicase domain of PolQ contributes to microhomology-mediated strand annealing. Chan et al., PLoS Genet. 2010, 6, e1001005; Kawamura et al., Int. J. Cancer 2004, 109, 9-16.
  • PolQ can promote end joining in the alt-NHEJ pathway by employing this annealing activity when ssDNA overhangs contain >2 base pair (bp) of microhomology. Kent et al., Elife 2016, 5, e13740; Kent, et al., Nat. Struct. Mol. Biol. 2015, 22, 230-7.
  • This reannealing activity is achieved through coupled actions of Rad51 interaction, followed by ATPase-mediated displacement of Rad51 from DSB damage sites. Once annealed, the polymerase domain extends the ssDNA ends and fills the remaining gaps.
  • PolQ The expression of PolQ is low in normal cells but significantly over-expressed in subsets of HRD ovarian, uterine, and breast cancers with associated poor prognosis. Higgins et al., Oncotarget 2010, 1, 175-84; Lemee et al., Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 13390-5; Ceccaldi et al., Nature 2015, 518, 258-62. Recent studies suggest that cancer cells with deficiency in HR, NHEJ, or ATM are highly dependent on PolQ expression. Ceccaldi et al., 2015, supra; Mateos-Gomez et al., 2015, supra; Wyatt et al., Mol.
  • PolQ inhibition could conceivably prevent the MMEJ-dependent functional reversion of BRCA1-or BRCA2-mutations that underlies the emergence of cisplatin and PARPi resistance in tumors. Zatreanu et al., Nat. Commun. 2021, 12, 3636) . Therefore, PolQ is an attractive target for synthetic lethal therapy in cancer containing a DNA repair defect.
  • composition comprising a compound of Formula (I) , or pharmaceutically acceptable salt, solvate, N-oxide, tautomer, stereoisomer, atropisomer, isotopic variant, prodrug, or deuterated compound thereof; and a pharmaceutically acceptable carrier.
  • a method of treating cancer in a subject comprising administering to the subject in need thereof a therapeutically effective amount of a compound of Formula (I) , or pharmaceutically acceptable salt, solvate, N-oxide, tautomer, stereoisomer, atropisomer, isotopic variant, prodrug, or deuterated compound thereof.
  • a method of inhibiting a PolQ comprising contacting the PolQ with an effective amount of a compound of Formula (I) , or pharmaceutically acceptable salt, solvate, N-oxide, tautomer, stereoisomer, atropisomer, isotopic variant, prodrug, or deuterated compound thereof.
  • each divalent linking group includes both the forward and backward forms of the divalent linking group.
  • —NR (CR’R”) includes both the forward and backward forms of the divalent linking group.
  • CR’R includes both the forward and backward forms of the divalent linking group.
  • CR’R includes both the forward and backward forms of the divalent linking group.
  • CR’R includes both the forward and backward forms of the divalent linking group.
  • CR’R –includes both –NR (CR’R”) –and – (CR’R”) NR–.
  • the Markush variables listed for that group are understood to be linking groups.
  • alkyl or “aryl” then it is understood that the “alkyl” or “aryl” represents a linking alkylene group or arylene group, respectively.
  • substituted means that an atom or group of atoms formally replaces hydrogen as a “substituent” attached to another group.
  • substituted refers to any level of substitution, e.g., mono-, di-, tri-, tetra-, or penta-substitution, where such substitution is permitted.
  • the substituents are independently selected, and substitution may be at any chemically accessible position. It is to be understood that substitution at a given atom is limited by valency.
  • optionally substituted means unsubstituted or substituted.
  • substituted means that a hydrogen atom is removed and replaced by a substituent.
  • a single divalent substituent e.g., oxo
  • substituents include, but are not limited to, D, halo, oxo, C 1 -C -6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkyl-NR c R d , – (CH 2 CH 2 O) o C 1 -C 6 alkyl wherein o is 1-10; C 2-6 alkenyl-NR c R d , C 2-6 alkynyl-NR c R d , –OC 2-6 alkyl-NR c R d , –CN, –NO 2 , –N 3 , –OR a , –SR a , –C (O) R b , –C (O) NR c R d , –CH 2 C (
  • C n -C m indicates a range which includes the endpoints, wherein n and m are integers and indicate the number of carbons.
  • C 1 -C 6 alkyl is specifically intended to individually disclose methyl, ethyl, C 3 alkyl, C 4 alkyl, C 5 alkyl, and C 6 alkyl.
  • C 0 alkyl refers to a covalent bond.
  • stable refers to a compound that is sufficiently robust to survive isolation to a useful degree of purity from a reaction mixture, and preferably capable of formulation into an efficacious therapeutic agent.
  • alkyl is meant to refer to a saturated hydrocarbon group which is straight-chained or branched.
  • An alkyl group can contain from about 1 to about 20, from about 2 to about 20, from about 1 to about 10, from about 1 to about 8, from about 1 to about 6, from about 1 to about 4, or from about 1 to about 3 carbon atoms.
  • alkyl can include any number of carbons, such as C 1 -C 2 alkyl, C 1 -C 3 alkyl, C 1 -C 4 alkyl, C 1 -C 5 alkyl, C 1 -C 6 alkyl, C 1 -C 7 alkyl, C 1 -C 8 alkyl, C 1 -C 9 alkyl, C 1 -C 10 alkyl, C 2 -C 3 alkyl, C 2 -C 4 alkyl, C 2 -C 5 alkyl, C 2 -C 6 alkyl, C 3 -C 4 alkyl, C 3 -C 5 alkyl, C 3 -C 6 alkyl, C 4 -C 5 alkyl, C 4 -C 6 alkyl, and C 5 -C 6 alkyl.
  • C 1 -C 2 alkyl C 1 -C 3 alkyl, C 1 -C 4 alkyl, C 1 -C 5 alkyl, C 1 -C 6 alkyl
  • C 1 -C 8 as in C 1 -C 8 alkyl is defined to identify the group as having 1, 2, 3, 4, 5, 6, 7, or 8 carbon atoms in a linear or branched arrangement.
  • alkyl groups include, but are not limited to, methyl (Me) , ethyl (Et) , propyl (e.g., n-propyl and isopropyl) , butyl (e.g., n-butyl, isobutyl, and t-butyl) , pentyl (e.g., n-pentyl, isopentyl, and neopentyl) , hexyl, heptyl, and octyl.
  • alkenyl is meant to refer to a hydrocarbon group having one or more double carbon-carbon bonds.
  • Alkenyl can include any number of carbons, such as C 2 -C 3 alkenyl, C 2 -C 4 alkenyl, C 2 -C 5 alkenyl, C 2 -C 6 alkenyl, C 2 -C 7 alkenyl, C 2 -C 8 alkenyl, C 2 -C 9 alkenyl, C 2 -C 10 alkenyl, C 3 -C 4 alkenyl, C 3 -C 5 alkenyl, C 3 -C 6 alkenyl, C 4 -C 5 alkenyl, C 4 -C 6 alkenyl and C 5 -C 6 alkenyl.
  • alkenyl groups include, but are not limited to, ethenyl, propenyl, butenyl, pentenyl, and hexenyl.
  • alkynyl is meant to refer to a hydrocarbon group having one or more triple carbon-carbon bonds.
  • Alkynyl can include any number of carbons, such as C 2 -C 3 alkynyl, C 2 -C 4 alkynyl, C 2 -C 5 alkynyl, C 2 -C 6 alkynyl, C 2 -C 7 alkynyl, C 2 -C 8 alkynyl, C 2 -C 9 alkynyl, C 2 -C 10 alkynyl, C 3 -C 4 alkynyl, C 3 -C 5 alkynyl, C 3 -C 6 alkynyl, C 4 -C 5 alkynyl, C 4 -C 6 alkynyl, and C 5 -C 6 alkynyl.
  • alkynyl groups include, but are not limited to, ethynyl, propynyl, butynyl, and
  • haloalkyl is meant to refer to an alkyl group having one or more halo as substituents.
  • haloalkyl groups include, but are not limited to, –CF 3 , –C 2 F 5 , –CHF 2 , –CH 2 F, –CCl 3 , –CHCl 2 , and –C 2 Cl 5 .
  • aryl is meant to refer to an unsubstituted or substituted monocyclic or polycyclic (e.g., having 2, 3, or 4 fused rings) aromatic hydrocarbon.
  • aryl groups have from about 6 to about 20 carbon atoms.
  • aryl groups have from about 6 to about 14 carbon atoms.
  • aryl groups have from about 6 to about 10 carbon atoms. Examples of aryl groups include, but are not limited to, phenyl, naphthyl, anthracenyl, phenanthrenyl, indanyl, and indenyl.
  • Cycloalkyl is meant to refer to an unsubstituted or substituted nonaromatic carbocycle.
  • Cycloalkyl groups can include mono-or polycyclic (e.g., having 2, 3, or 4 rings) ring systems, including fused rings, spirocyclic rings, and bridged rings (e.g., a bridged bicycloalkyl group) .
  • cycloalkyl groups can have from about 3 to about 20 carbon atoms, from about 3 to about 14 carbon atoms, from about 3 to about 10 carbon atoms, or from about 3 to 7 carbon atoms. Cycloalkyl groups can further have 0, 1, 2, or 3 double bonds and/or 0, 1, or 2 triple bonds.
  • the cycloalkyl is C 3 -C 7 monocyclic cycloalkyl.
  • the cycloalkyl is C 4- C 10 spiro or bridged cycloalkyl.
  • cycloalkyl groups include, but are not limited to, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclopentenyl, cyclohexenyl, cyclohexadienyl, cycloheptatrienyl, norbornyl, norpinyl, norcaranyl, cubanyl, adamantanyl, bicyclo [1.1.1] pentyl, bicyclo [2.1.1] hexyl, bicyclo [2.2.1] heptanyl, bicyclo [3.1.1] -heptanyl, bicyclo [2.2.2] octanyl, and spiro [3.3] heptanyl.
  • heteroaryl is meant to refer to an unsubstituted or substituted aromatic heterocycle having at least one heteroatom ring member such as boron, sulfur, oxygen, or nitrogen.
  • Heteroaryl groups include monocyclic and polycyclic (e.g., having 2, 3, or 4 fused rings) systems. Any ring-forming N atom in a heteroaryl group can also be oxidized to form an N-oxo moiety.
  • heteroaryl groups include, are not limited to, pyridyl, N-oxopyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, triazinyl, furyl, quinolyl, isoquinolyl, thienyl, imidazolyl, thiazolyl, indolyl, pyrrolyl, oxazolyl, benzofuryl, benzothienyl, benzothiazolyl, isoxazolyl, pyrazolyl, triazolyl, tetrazolyl, indazolyl, 1, 2, 4-thiadiazolyl, isothiazolyl, benzothienyl, purinyl, carbazolyl, benzimidazolyl, and indolinyl.
  • the heteroaryl group has from about 1 to about 20 carbon atoms or from about 3 to about 20 carbon atoms. In certain embodiments, the heteroaryl group contains from about 3 to about 14, from about 3 to about 7, about 5, or about 6 ring-forming atoms. In certain embodiments, the heteroaryl group has from about 1 to about 4, from about 1 to about 3, about 1, or about 2 heteroatoms.
  • Heterocycloalkyl groups include monocyclic and polycyclic (e.g., having 2 fused rings) systems.
  • heterocycloalkyl Included in heterocycloalkyl are monocyclic and polycyclic 3-10, 4-10, 3-7, 4-7, and 5-6 membered heterocycloalkyl groups.
  • Heterocycloalkyl groups can also include spirocyclic and bridged rings (e.g., a 5-10 membered bridged biheterocycloalkyl) .
  • the heterocycloalkyl group contains 0 to 3 double bonds. In certain embodiments, the heterocycloalkyl group contains 0 to 2 double bonds.
  • heterocycloalkyl moieties that have one or more aromatic rings fused to the non-aromatic heterocyclic ring, for example, benzo or thienyl derivatives of piperidine, morpholine, azepine, etc.
  • the heterocycloalkyl group contains 3 to 10 ring-forming atoms, 4 to 10 ring-forming atoms, 3 to 7 ring-forming atoms, or 5 to 6 ring-forming atoms.
  • the heterocycloalkyl group has 1 to 4 heteroatoms, 1 to 3 heteroatoms, 1 to 2 heteroatoms or 1 heteroatom.
  • the heterocycloalkyl is a monocyclic 4-6 membered heterocycloalkyl having 1 or 2 heteroatoms.
  • heterocycloalkyl groups include, but are not limited to, pyrrolidin-2-onyl, l, 3-isoxazolidin-2-onyl, pyranyl, tetrahydropyranyl, oxetanyl, azetidinyl, morpholino, thiomorpholino, piperazinyl, tetrahydrofuranyl, tetrahydrothienyl, piperidinyl, pyrrolidinyl, isoxazolidinyl, isothiazolidinyl, pyrazolidinyl, oxazolidinyl, thiazolidinyl, imidazolidinyl, azepanyl, benzazepinyl, 1, 2, 3, 4-tetrahydroisoquinolinyl, azabicyclo [3.1.0] hexanyl, diazabicyclo [3.
  • heterocycloalkyl is meant to refer to any three to ten membered monocyclic or bicyclic, saturated ring structure containing at least one heteroatom selected from the group consisting of O, N, and S.
  • the heterocycloalkyl group may be attached at any heteroatom or carbon atom of the ring such that the result is a stable structure.
  • heterocycloalkyl groups include, but are not limited to, azepanyl, aziridinyl, azetidinyl, pyrrolidinyl, dioxolanyl, imidazolidinyl, pyrazolidinyl, piperazinyl, piperidinyl, dioxanyl, morpholinyl, dithianyl, thiomorpholinyl, oxazepanyl, oxiranyl, oxetanyl, quinuclidinyl, tetrahydrofuranyl, tetrahydropyranyl, and piperazinyl.
  • halo or halogen is meant to refer to fluoro, chloro, bromo, and iodo.
  • alkoxy is meant to refer to an –O-alkyl group.
  • alkoxy groups include, but are not limited to, methoxy, ethoxy, propoxy (e.g., n-propoxy and isopropoxy) , and t-butoxy.
  • hydroxylalkyl is meant to refer to an alkyl group substituted by —OH.
  • cyanoalkyl is meant to refer to an alkyl group substituted by —CN.
  • alkoxyalkyl is meant to refer to an alkyl group substituted by an alkoxy group.
  • haloalkoxy is meant to refer to an —O- (haloalkyl) group.
  • arylalkyl or “aralkyl” is meant to refer to alkyl substituted by aryl.
  • An example of the arylalkyl group is benzyl.
  • cycloalkylalkyl is meant to refer to alkyl substituted by cycloalkyl.
  • heteroarylalkyl is meant to refer to alkyl substituted by heteroaryl.
  • heterocycloalkylalkyl is meant to refer to alkyl substituted by heterocycloalkyl.
  • the compounds of the disclosure, and salts thereof are substantially isolated.
  • substantially isolated is meant that the compound is at least partially or substantially separated from the environment in which was formed or detected.
  • Substantial separation can include compositions containing at least about 50%, at least about 60%, at least about 70%, at least about 80%, at least about 90%, at least about 95%, at least about 97%, or at least about 99%by weight of the compound of the disclosure, or a salt thereof.
  • phrases “pharmaceutically acceptable” is employed herein to refer to those compounds, materials, compositions, and/or dosage forms which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of human beings and animals without excessive toxicity, irritation, allergic response, or other problem or complication, commensurate with a reasonable benefit/risk ratio.
  • pharmaceutically acceptable excipient refers to a substance that is non-toxic, biologically tolerable, and otherwise biologically suitable for administration to a subject, such as an inert substance, added to a pharmacological composition or otherwise used as a vehicle, carrier, or diluent to facilitate administration of an agent and that is compatible therewith.
  • excipients include calcium carbonate, calcium phosphate, various sugars and types of starch, cellulose derivatives, gelatin, vegetable oils, and polyethylene glycols.
  • solvate refers to a physical association of a compound with one or more solvent molecules.
  • subject refers to an animal, including, but not limited to, a primate (e.g., human) , cow, pig, sheep, goat, horse, dog, cat, rabbit, rat, or mouse.
  • primate e.g., human
  • subject and patient are used interchangeably herein in reference, for example, to a mammalian subject, such as a human subject. In one embodiment, the subject is a human.
  • treating or “treatment” of a disease or disorder refers, in one embodiment, to ameliorating the disease or disorder (i.e., arresting or reducing the development of the disease or at least one of the clinical symptoms thereof) .
  • “treating” or “treatment” refers to ameliorating at least one physical parameter, which may not be discernible by the subject.
  • “treating” or “treatment” refers to modulating the disease or disorder, either physically, (e.g., stabilization of a discernible symptom) , physiologically, (e.g., stabilization of a physical parameter) , or both.
  • “treating” or “treatment” refers to delaying the onset of the disease or disorder.
  • isotopic variant refers to a compound that contains proportions of isotopes at one or more of the atoms that constitute such compound that is greater than natural abundance.
  • an “isotopic variant” of a compound can be radiolabeled, that is, contain one or more radioactive isotopes, or can be labeled with non-radioactive isotopes such as for example, deuterium ( 2 H or D) , carbon-13 ( 13 C) , nitrogen-15 ( 15 N) , or the like.
  • any hydrogen may be 2 H/D
  • any carbon may be 13 C
  • any nitrogen may be 15 N, and that the presence and placement of such atoms may be determined within the skill of the art.
  • ring A is C 5 -C 10 cycloalkyl, 5-10 membered heterocycloalkyl, C 6 -C 10 aryl, or 5-10 membered heteroaryl;
  • Cy is C 3 -C 10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6 -C 10 aryl, or 5-10 membered heteroaryl;
  • n is an integer of 1, 2, 3, 4, or 5;
  • n is an integer of 1, 2, 3, 4, or 5;
  • each R 1 is independently H, D, –CN, –NO 2 , –N 3 , oxo, –SF 5 , halo, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6 -C 10 aryl, 5-10 membered heteroaryl, –NR C R D , –OR A , –SR A , –NR C OR A , –C (O) R B , –C (O) NR C R D , –C (O) OR A , –OC (O) R B , –NR C C (O) R B , –S (O) R B , –S (O) 2 R B , –S (O) NR C R D , –NR C S (O) 2 R D , –S (O) 2
  • R 1 two R 1 together with the atom (s) to which they are attached form oxo, C 3 -C 7 cycloalkyl, 4-7 membered heterocycloalkyl, phenyl, or 5-6 membered heteroaryl; wherein the cycloalkyl, heterocycloalkyl, phenyl, and heteroaryl are each optionally substituted by 1, 2, 3, or 4 substituents, each of which is independently R 1A ;
  • each R 1A is independently D, halo, –CN, –OH, –NH 2 , –NO 2 , –SF 5 , oxo, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 3 -C 6 cycloalkyl, 4-6 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, –NR c R d , –OR a , –SR a , –C (O) R b , –C (O) NR c R d , –C (O) OR a , –OC (O) R b , –OC (O) NR c R d , –NR c C (O) R b , –NR c C (O) NR c R d , –NR c C (O) OR a , –S (O)
  • each R 2A is independently D, halo, –CN, –OH, –NH 2 , –NO 2 , –N 3 , oxo, C 1 -C 6 alkyl, –OC 1 -C 6 alkyl, C 1 -C 6 haloalkyl, –OC 1 -C 6 haloalkyl, –NHC 1 -C 3 alkyl, –N (C 1 -C 3 alkyl) 2 , C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl, or 4-6 membered heterocycloalkyl; wherein the alkyl, alkenyl, alkynyl, cycloalkyl, and heterocycloalkyl are each optionally substituted with D, halo, –CN, –OH, –NH 2 , C 1 -C 6 alkyl, C 1 -C 6 haloalkyl,
  • each R 2B is independently D, halo, oxo, –CN, –OH, –NH 2 , –NO 2 , C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, –O-C 1 -C 6 alkyl, or –O-C 1 -C 6 haloalkyl;
  • R 3 is:
  • each R 4 is independently H, D, halo, –CN, –NO 2 , –N 3 , oxo, –OR A1 , –OR A2 , C 1 -C 4 alkyl, –C (O) R B , –C (O) NR C R D , –C (O) OR A , –C (O) NR C S (O) R B , –C (O) NR C S (O) 2 R B , –OC (O) R B , –OC (O) NR C R D , –NR C R D , –NR C C (O) R B , –NR C C (O) NR C R D , –NR C C (O) OR A , —SR A , –S (O) R B , –S (O) 2 R B , –S (O) NR C R D , –NR C S (O) 2 R D , –S (O
  • R A1 is independently H, D, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, or C 2 -C 8 alkynyl; wherein the alkyl, alkenyl, and alkynyl are each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 11 ;
  • each R 11 is independently D, –CN, –N 3 , halo, –NO 2 , oxo, –OR a , –SR a , –NR c R d , –C (O) R b , –C (O) NR c R d , –C (O) OR a , –OC (O) R b , –OC (O) NR c R d , –NR c C (O) R b , –NR c C (O) NR c R d , –NR c C (O) OR a , –S (O) R b , –S (O) 2 R b , –S (O) NR c R d , –NR c S (O) 2 R d , –S (O) 2 NR c R d , –NR c S (O) 2 NR c R d ,
  • R A2 is C 3 -C 14 cycloalkyl, 4-14 membered heterocycloalkyl, C 6 -C 14 aryl, or 5-14 membered heteroaryl; wherein the cycloalkyl, heterocycloalkyl, aryl, and heteroaryl are each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 12 ;
  • each R 12 is independently H, D, halo, –CN, –N 3 , –NO 2 , oxo, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 6 -C 10 aryl, C 3 -C 10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, –OR a , –SR a , –C (O) R b , –C (O) NR c R d , –C (O) OR a , –OC (O) R b , –OC (O) NR c R d , –NR c R d , –NR c C (O) R b , –NR c C (O) NR c R d , –NR c C (O) OR a , –B (OR e ) (
  • each R 5 , R 6 , and R 7 is independently H, D, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 3 -C 7 cycloalkyl, 4-7 membered heterocycloalkyl, or phenyl; wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, and phenyl are each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, halo, –CN, –NO 2 , –N 3 , oxo, –NR C R D , –OR A , –SR A , –C (O) R B , –C (O) NR C R D , –OC (O) NR C R D , –NR C C (O) R B , –NR C C (O) NR C R D , –NR
  • each R 8 is independently C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 3 -C 10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6 -C 10 aryl, or 5-10 membered heteroaryl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 8A ;
  • each R 9 and R 10 is independently H, D, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 7 cycloalkyl, 4-7 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl; wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, phenyl, heteroaryl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, and heterocycloalkylalkyl are each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –OH, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 halo
  • each R A is independently H, D, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6 -C 10 aryl, 5-10 membered heteroaryl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl; wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, and heterocyclo-alkylalkyl are each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –CN, halo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1
  • each R B is independently H, D, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6 -C 10 aryl, 5-10 membered heteroaryl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl; wherein the alkyl, alkenyl, alkynyl, cycloalkyl, hetero-cycloalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, and heterocycloalkylalkyl are each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R B1 ;
  • each R B1 is independently D, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 haloalkyl, C 0 -C 4 alkyl-C 3 -C 10 cycloalkyl, C 0 -C 4 alkyl-4-10 membered heterocycloalkyl, C 0 -C 4 alkyl-C 6 -C 10 aryl, C 0 -C 4 alkyl-5-10 membered heteroaryl, –SF 5 , –C (O) R b , –OC (O) NR c R d , –OR a , –NR c R d , –NR c C (O) R b ,
  • each R C and R D is independently H, D, –CN, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6 -C 10 aryl, 5-10 membered heteroaryl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl; wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, and heterocycloalkylalkyl are each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C
  • R C and R D together with the N atom to which they are attached form 4-7 membered heterocycloalkyl, optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –OH, oxo, –CN, –NH 2 , –NH (C 1 -C 4 alkyl) , –N (C 1 -C 4 alkyl) 2 , halo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, –OC 1 -C 4 alkyl, or –OC 1 -C 4 haloalkyl;
  • each R a and R a1 is independently H, D, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, phenyl, C 3 -C 7 cycloalkyl, 5-6 membered heteroaryl, or 4-7 membered heterocycloalkyl, wherein the alkyl, alkenyl, alkynyl, phenyl, cycloalkyl, heteroaryl, and heterocycloalkyl are each optionally substituted with 1, 2, 3, 4 or 5 substituents, each of which is independently D, halo, –OH, –CN, –NH 2 , –NH (C 1 -C 4 alkyl) , –N (C 1 -C 4 alkyl) 2 , C 1 -C 4 alkyl, –OC 1 -C 4 alkyl, C 1 -C 4 haloalkyl, or —OC 1 -C 4 haloalkyl
  • each R b and R b1 is independently H, D, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, phenyl, C 3- C 7 cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl; wherein the alkyl, alkenyl, alkynyl, phenyl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, and heterocycloalkylalkyl are each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –OH, –CN, –NH 2 , –NH (C 1 -C 4 alkyl) , –N (C 1
  • each R c and R d is independently H, D, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 6 -C 10 aryl, 5-10 membered heteroaryl, C 3 -C 10 cycloalkyl, 4-10 membered heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, heterocycloalkylalkyl, arylcycloalkyl, arylheterocyclo-alkyl, arylheteroaryl, biaryl, heteroarylcycloalkyl, heteroarylheterocycloalkyl, heteroarylaryl, or biheteroaryl; wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl,
  • R c and R d together with the N atom to which they are attached form 4-7 membered heterocycloalkyl, optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –OH, –CN, –NH 2 , –NH (C 1 -C 4 alkyl) , –N (C 1 -C 4 alkyl) 2 , halo, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkyl, C 1 -C 4 haloalkoxy, C 1 -C 4 hydroxyalkyl, C 1 -C 4 cyanoalkyl, C 6 -C 10 aryl, 5-10 membered heteroaryl, C 1 -C 4 alkoxy-C 1 -C 4 alkyl, or C 1 -C 4 alkoxy-C 1 -C 4 alkoxy;
  • each R E and R e is independently H, D, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 2 -C 4 alkenyl, (C 1 -C 4 alkoxy) -C 1 -C 4 alkyl, C 2 -C 4 alkynyl, C 6 -C 10 aryl, 5-10 membered heteroaryl, C 3 -C 10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6 -C 10 aryl-C 1 -C 4 alkyl, C 3 -C 10 cycloalkyl-C 1 -C 4 alkyl, 5-10 membered heteroaryl-C 1 -C 4 alkyl, or 4-10 membered heterocycloalkyl-C 1 -C 4 alkyl;
  • each R F and R f is independently H, D, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 6 -C 10 aryl, 5-10 membered heteroaryl, C 3 -C 10 cycloalkyl, or 4-10 membered heterocycloalkyl;
  • each R G , R H , R I , R g , R h , and R i is independently C 1 -C 4 alkyl or phenyl.
  • the compound provided herein is neither 2'-chloro-5'-methoxy-6-methyl-N- (5- (2-oxo-2- (pyrrolidin-1-yl) ethyl) -1, 3, 4-thiadiazol-2-yl) - [4, 4'-bipyridine] -3-carboxamide nor 2'-chloro-N- (5- (2- (dimethylamino) -2-oxoethyl) -1, 3, 4-thiadiazol-2-yl) -5'-methoxy-6-methyl- [4, 4'-bipyridine] -3-carboxamide.
  • ring A is C 5 -C 10 cycloalkyl, 5-10 membered heterocycloalkyl, C 6 -C 10 aryl, or 5-10 membered heteroaryl.
  • ring A is C 5 -C 10 cycloalkyl. In certain embodiments, ring A is saturated C 5 -C 10 cycloalkyl or partially unsaturated C 5 -C 10 cycloalkyl. In certain embodiments, ring A is cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclopentenyl, cyclopentadienyl, and cyclohexenyl.
  • ring A is 5-10 membered heterocycloalkyl. In certain embodiments, ring A is saturated 5-10 membered heterocycloalkyl or partially unsaturated 5-10 membered heterocycloalkyl. In certain embodiments, ring A is azetidinyl, oxetanyl, thietanyl, pyrrolidinyl, tetrahydrofuranyl, tetrahydrothiophenyl, piperidinyl, dioxanyl, tetrahydropyranyl, tetrahydrothiopyranyl, piperazinyl, morpholinyl, pyridin-2 (1H) -onyl, 1, 2, 4-triazin-5 (4H) -onyl, pyrimidin-2 (1H) -onyl, or pyrazin-2 (1H) -onyl. In certain embodiments, ring A is pyridin-2 (1H) -onyl.
  • ring A is C 6 -C 10 aryl. In certain embodiments, ring A is phenyl or naphthyl.
  • ring A is 5-10 membered heteroaryl. In certain embodiments, ring A is monocyclic 5-10 membered heteroaryl. In certain embodiments, ring A is 5-membered heteroaryl. In certain embodiments, ring A is pyrrolyl, furanyl, thiophenyl, imidazolyl, oxazolyl, thiazolyl, tetrazolyl, pyrazolyl, 1, 2, 4-triazolyl, 1, 2, 3-triazolyl, thiadiazolyl, or oxadiazolyl. In certain embodiments, ring A is imidazolyl. In certain embodiments, ring A is 6-membered heteroaryl.
  • ring A is pyridinyl, pyrimidinyl, pyrazinyl, or pyridazinyl. In certain embodiments, ring A is pyridinyl. In certain embodiments, ring A is pyridazinyl. In certain embodiments, ring A is 7-10 membered heteroaryl. In certain embodiments, ring A is 9-membered heteroaryl. In certain embodiments, ring A is [1, 2, 4] triazolo [1, 5-a] pyridinyl or imidazo [1, 2-a]pyridinyl.
  • ring A is 5-or 6-membered heteroaryl. In certain embodiments, ring A is imidazolyl, pyridinyl, or pyridazinyl. In certain embodiments, ring A is imidazolyl or pyridinyl.
  • the moiety has the structure of
  • each X 1 , X 2 , X 3 , and X 4 is independently N or CR 1 ;
  • each X 5 is independently NR 1 , O, or S;
  • each R 1 is as defined herein.
  • the moiety has the structure of wherein X 1 , X 2 , X 3 , and X 4 are each as defined herein.
  • one of X 1 , X 2 , X 3 , and X 4 is N; and the remaining three are each independently CR 1 , wherein R 1 is as defined herein.
  • two of X 1 , X 2 , X 3 , and X 4 are each N; and the remaining two are each independently CR 1 , wherein R 1 is as defined herein.
  • X 1 , X 2 , X 3 , and X 4 are each independently CR 1 , wherein R 1 is as defined herein.
  • the moiety has the structure of wherein R 1 , X 1 , and X 4 are each as defined herein.
  • the moiety has the structure of wherein X 1 , X 2 , and X 3 are each as defined herein.
  • one of X 1 , X 2 , and X 3 is N; and the remaining two are each independently CR 1 , wherein R 1 is as defined herein.
  • two of X 1 , X 2 , and X 3 are N; and the remaining one is CR 1 , wherein R 1 is as defined herein.
  • X 1 , X 2 , and X 3 are each independently CR 1 , wherein R 1 is as defined herein.
  • the moiety has the structure of wherein each X 1 , X 3 , and X 5 is as defined herein.
  • each X 1 and X 3 is independently CR 1 ; and X 5 is NR 1 , O or S; wherein each R 1 is as defined herein.
  • X 1 is N; X 3 is CR 1 ; and X 5 is NR 1 , O or S; wherein each R 1 is as defined herein.
  • X 1 is CR 1 ; X 3 is N; and X 5 is NR 1 , O or S; wherein each R 1 is as defined herein.
  • X 1 is N; X 3 is N; and X 5 is NR 1 , O or S; wherein R 1 is as defined herein.
  • the moiety has the structure of wherein each R 1 is as defined herein.
  • the moiety has the structure of wherein each R 1 is as defined herein.
  • the moiety has the structure of wherein each R 1 is as defined herein.
  • the moiety has the structure of wherein each R 1 is as defined herein.
  • the moiety has the structure of wherein each R 1 is as defined herein. In certain embodiments, the moiety has the structure of wherein each R 1 is as defined herein. In certain embodiments, the moiety has the structure of wherein each R 1 is as defined herein. In certain embodiments, the moiety has the structure of wherein each R 1 is as defined herein. In certain embodiments, the moiety has the structure of wherein each R 1 is as defined herein. In certain embodiments, the moiety has the structure of wherein each R 1 is as defined herein.
  • the moiety has the structure of
  • Cy is C 3 -C 10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6 -C 10 aryl, or 5-10 membered heteroaryl.
  • Cy is C 3 -C 10 cycloalkyl. In certain embodiments, Cy is saturated C 3 -C 10 cycloalkyl or partially unsaturated C 5 -C 10 cycloalkyl. In certain embodiments, Cy is saturated C 5 -C 7 cycloalkyl. In certain embodiments, Cy is unsaturated C 5 -C 7 cycloalkyl. In certain embodiments, Cy is cyclopentyl, cyclohexyl, cycloheptyl, cyclopentenyl, or cyclohexenyl.
  • Cy is 4-10 membered heterocycloalkyl. In certain embodiments, Cy is saturated 4-10 membered heterocycloalkyl or partially unsaturated 5-10 membered heterocycloalkyl. In certain embodiments, Cy is saturated 5-7 membered heterocycloalkyl or partially unsaturated 5-7 membered heterocycloalkyl. In certain embodiments, each heterocycloalkyl has one or two heteroatoms, each of which is independently N, O, or S.
  • Cy is C 6- C 10 aryl. In certain embodiments, Cy is phenyl or naphthyl. In certain embodiments, Cy is phenyl.
  • Cy is 5-10 membered heteroaryl. In certain embodiments, Cy is monocyclic 5-10 membered heteroaryl. In certain embodiments, Cy is 6-membered heteroaryl. In certain embodiments, Cy is pyridinyl. In certain embodiments, Cy is 5-10 membered heteroaryl having one or two heteroatoms, each of which is independently N, O, or S. In certain embodiments, Cy is phenyl or 6-membered heteroaryl. In certain embodiments, Cy is phenyl or pyridinyl. In certain embodiments, Cy is phenyl or pyridin-4-yl.
  • the moiety has the structure of wherein Y 1 , Y 2 , Y 3 , Y 4 , and Y 5 are each independently N or CR 2 ; and each R 2 is as defined herein.
  • one of Y 1 , Y 2 , Y 3 , Y 4 , and Y 5 is N; and the remaining four are each independently CR 2 , wherein R 2 is as defined herein.
  • two of Y 1 , Y 2 , Y 3 , Y 4 , and Y 5 are N; and the remaining three are each independently CR 2 , wherein R 2 is as defined herein.
  • Y 1 , Y 2 , Y 3 , Y 4 , and Y 5 are each independently CR 2 , wherein R 2 is as defined herein.
  • the moiety has the structure of wherein each R 2 is as defined herein.
  • the moiety has the structure of wherein each R 2 is as defined herein. In certain embodiments, the moiety has the structure of wherein each R 2 is as defined herein. In certain embodiments, the moiety has the structure of wherein each R 2 is as defined herein. In certain embodiments, the moiety has the structure of wherein each R 2 is as defined herein. In certain embodiments, the moiety has the structure of wherein each R 2 is as defined herein.
  • the moiety has the structure of
  • the moiety has the structure of
  • each R 1 is independently H, D, –CN, –NO 2 , –N 3 , oxo, –SF 5 , halo, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6 -C 10 aryl, 5-10 membered heteroaryl, –NR C R D , –OR A , –SR A , –NR C OR A , –C (O) R B , –C (O) NR C R D , –C (O) OR A , –OC (O) R B , –NR C C (O) R B , –S (O) R B , –S (O) 2 R B , –S (O) NR C R D , –NR C S (O) 2 R D , –S
  • each R 1 is independently selected from H, D, –CN, –NO 2 , –N 3 , oxo, –SF 5 , halo, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl, 4-6 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, –OR A , –SR A , –OC (O) R B , –OC (O) NR C R D , –NR C R D , –NR C C (O) R B , or –NR C C (O) OR A ; wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, phenyl, and heteroaryl are each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 1A ;
  • each R 1 is independently H, D, –CN, –NO 2 , –N 3 , oxo, –SF 5 , halo, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl, 4-6 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, –OR A , –SR A , –OC (O) R B , –OC (O) NR C R D , –NR C R D , –NR C C (O) R B , or –NR C C (O) OR A ; wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, phenyl, and heteroaryl are each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 1A ; and each
  • R 1 is H. In certain embodiments, R 1 is D. In certain embodiments, R 1 is –CN. In certain embodiments, R 1 is –NO 2 . In certain embodiments, R 1 is –N 3 . In certain embodiments, R 1 is –SF 5 . In certain embodiments, R 1 is halo. In certain embodiments, R 1 is –F, –Cl, –Br, or –I. In certain embodiments, R 1 is –F. In certain embodiments, R 1 is –Cl. In certain embodiments, R 1 is –Br. In certain embodiments, R 1 is –I.
  • R 1 is –NR C R D , wherein R C and R D are each as defined herein.
  • R 1 is –NH 2 , –NHCH 3 , –N (CH 3 ) 2 , –NHCH 2 CH 3 , –N (CH 2 CH 3 ) 2 , –NHCH 2 CH 2 CH 3 , –N (CH 2 CH 2 CH 3 ) 2 , –NHCH (CH 3 ) 2 , –NHCH 2 CH 2 OH, –N (CN) CH 3 ,
  • R 1 is –OR A , wherein R A is as defined herein.
  • R 1 is –OH, –OCH 3 , –OCH 2 CH 3 , –OCH 2 CH 2 CH 3 , –OCH (CH 3 ) 2 , –OCH 2 F, –OCHF 2 , –OCF 3 , –OCH 2 CH 2 OCHF 2 ,
  • R 1 is –SR A , wherein R A is as defined herein. In certain embodiments, R 1 is –SCH 3 . In certain embodiments, R 1 is –NR C OR A , wherein R A and R C are each as defined herein. In certain embodiments, R 1 is –C (O) R B , wherein R B is as defined herein. In certain embodiments, R 1 is, –C (O) CH 3 , –C (O) CH 2 CH 3 , –C (O) CH (CH 3 ) 2 , or In certain embodiments, R 1 is –C (O) NR C R D , wherein R C and R D are each as defined herein.
  • R 1 is –C (O) NH 2 , –C (O) NHCH 3 , or –C (O) N (CH 3 ) 2 .
  • R 1 is –C (O) OR A , wherein R A is as defined herein.
  • R 1 is -OC (O) R B , wherein R B is as defined herein.
  • R 1 is –NR C C (O) R B , wherein R B and R C are each as defined herein.
  • R 1 is –NHC (O) CH 3 , –NCH 3 C (O) CH 3 ,
  • R 1 is C 1 -C 6 alkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 1A , wherein R 1A is as defined herein.
  • R 1 is methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, t-butyl, –CH 2 F, –CHF 2 , –CF 3 , –CH 2 CH 2 F, –CH 2 CHF 2 , –CH 2 CF 3 , –CD 3 , –CH 2 OH, –CH 2 OMe, –CH 2 CN,
  • R 1 is methyl or –CD 3 .
  • R 1 is methyl.
  • R 1 is C 2 -C 6 alkenyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 1A , wherein R 1A is as defined herein. In certain embodiments, R 1 is C 2 -C 6 alkynyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 1A , wherein R 1A is as defined herein. In certain embodiments, R 1 is
  • R 1 is C 3 -C 10 cycloalkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 1A , wherein R 1A is as defined herein.
  • R 1 is saturated C 3 -C 10 cycloalkyl or partially unsaturated C 3 -C 10 cycloalkyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 1A , wherein R 1A is as defined herein.
  • R 1 is cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopentenyl, cyclopentadienyl, or cyclohexenyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 1A , wherein R 1A is as defined herein.
  • R 1 is 4-10 membered heterocycloalkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 1A , wherein R 1A is as defined herein.
  • R 1 is saturated 4-10 membered heterocycloalkyl or partially unsaturated 4-10 membered heterocycloalkyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 1A , wherein R 1A is as defined herein.
  • R 1 is azetidinyl, oxetanyl, pyrrolidinyl, tetrahydrofuranyl, piperidinyl, dioxanyl, piperazinyl, morpholinyl, 2, 6-diazaspiro [3.3] heptanyl, 2, 6-diazaspiro [3.3] heptanyl, 2-oxa-6-azaspiro [3.3] heptanyl, 7-oxa-4-azaspiro [2.5] octanyl, 3-azabicyclo [4.1.0] heptanyl, 3-azabicyclo [4.1.0] heptan-2-onyl, 4-oxa-7-azaspiro [2.5] octan-8-onyl, morpholin-3-onyl, piperazin-2-onyl, pyrrolidin-2-onyl, pyridin-2 (1H) -onyl, or 6, 7-dihydropyrazolo [
  • R 1 is C 6 -C 10 aryl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 1A , wherein R 1A is as defined herein.
  • R 1 is phenyl or naphthyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 1A , wherein R 1A is as defined herein.
  • R 1 is 5-10 membered heteroaryl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 1A , wherein R 1A is as defined herein.
  • R 1 is pyrrolyl, furanyl, thiophenyl, imidazolyl, oxazolyl, thiazolyl, tetrazolyl, pyrazolyl, triazolyl, 1, 3, 4-thiadiazolyl, 1, 3, 4-oxadiazolyl, pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, indolyl, or isoindolyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 1A , wherein R 1A is as defined herein.
  • each R 1 is independently (i) H, D, –CN, or halo; or (ii) C 1 -C 6 alkyl or 5-10 membered heteroaryl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 1A , wherein R 1A is as defined herein.
  • each R 1 is independently (i) H, D, or –CN; or (ii) C 1 -C 6 alkyl or 5-membered heteroaryl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 1A , wherein R 1A is as defined herein.
  • each R 1 is independently H, D, –CN, methyl, or 1-methyl-pyrazolyl.
  • each R 1 is independently H or methyl.
  • one of the R 1 groups is (i) –CN or halo; or (ii) C 1 -C 6 alkyl or 5-10 membered heteroaryl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 1A , wherein R 1A is as defined herein.
  • one of the R 1 groups is –CN, methyl, or 1-methylpyrazolyl. In certain embodiments, one of the R 1 groups is methyl.
  • one of the R 1 groups is (i) –CN or halo; or (ii) C 1 -C 6 alkyl or 5-10 membered heteroaryl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 1A , wherein R 1A is as defined herein; and the remaining R 1 groups are each H.
  • one of the R 1 groups is –CN, methyl, or 1-methylpyrazolyl; and the remaining R 1 groups are each H.
  • one of the R 1 groups is methyl; and the remaining R 1 groups are each H.
  • two R 1 together with the atom (s) to which they are attached form (i) oxo; or (ii) C 3 -C 7 cycloalkyl, 4-7 membered heterocycloalkyl, phenyl, or 5-6 membered heteroaryl, each optionally substituted with 1, 2, 3, or 4 substituents, each of which is independently R 1A , wherein R 1A is as defined herein.
  • two R 1 together with the same atom to which they are attached form oxo.
  • two R 1 together with the atom (s) to which they are attached form C 3 -C 7 cycloalkyl optionally substituted by 1, 2, 3, or 4 substituents, each of which is independently R 1A , wherein R 1A is as defined herein.
  • two R 1 together with the atom (s) to which they are attached form cyclopropyl or cyclobutyl, each optionally substituted by 1, 2, 3, or 4 substituents, each of which is independently R 1A , wherein R 1A is as defined herein.
  • two R 1 together with the atom (s) to which they are attached form 4-7 membered heterocycloalkyl optionally substituted by 1, 2, 3, or 4 substituents, each of which is independently R 1A , wherein R 1A is as defined herein.
  • two R 1 together with the atoms to which they are attached form phenyl optionally substituted by 1, 2, 3, or 4 substituents, each of which is independently R 1A , wherein R 1A is as defined herein.
  • two R 1 together with the atoms to which they are attached form 5-6 membered heteroaryl ring optionally substituted by 1, 2, 3, or 4 substituents, each of which is independently R 1A , wherein R 1A is as defined herein.
  • each R 1A is independently D, halo, –CN, –OH, –NH 2 , –NO 2 , –SF 5 , oxo, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 3 -C 6 cycloalkyl, 4-6 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, –NR c R d , –OR a , –SR a , –C (O) R b , –C (O) NR c R d , –C (O) OR a , –OC (O) R b , –OC (O) NR c R d , –NR c C (O) R b , –NR c C (O) NR c R d , –NR c C (O) OR a , –NR c C
  • R 1A is D, halo, –CN, –OH, –NH 2 , –NO 2 , –SF 5 , or oxo.
  • R 1A is D.
  • R 1A is halo.
  • R 1A is –F, –Cl, –Br, or –I.
  • R 1A is –CN.
  • R 1A is –OH.
  • R 1A is –NH 2 .
  • R 1A is –NO 2 .
  • R 1A is –SF 5 .
  • R 1A is oxo.
  • R 1A is C 1 -C 4 alkyl optionally substituted with D, halo, –CN, –OH, –NH 2 , oxo, –NR c1 R d1 , –OR a1 , –SR a1 , C 1 -C 6 alkyl, or C 1- C 6 haloalkyl; wherein each R a1 , R c1 , and R d1 is as defined herein.
  • R 1A is –CH 3 , –CH 2 CH 3 , –CH 2 CH 2 CH 3 , —CH (CH 3 ) 2 , –CH 2 CH 2 CH 2 CH 3 , –CH 2 CH (CH 3 ) 2 , –C (CH 3 ) 3 , –CH 2 F, –CHF 2 , –CF 3 , –CH 2 CH 2 F, –CH 2 CHF 2 , –CH 2 CF 3 , –CF 2 CH 3 , –CF 2 CF 3 , –CF 2 CH 2 CH 3 , —CH 2 OH, —CH 2 CH 2 OH, –CH (OH) CH 3 , –CH 2 CH 2 CH 2 OH, –CH (OH) CH 2 CH 2 OH, –CH 2 CN, –CH 2 CH 2 CN, or –CH 2 CH 2 CH 2 CN.
  • R 2 is H, D, halo, –CN, –NO 2 , –N 3 , or –SF 5 .
  • R 2 is H.
  • R 2 is D.
  • R 2 is halo.
  • R 2 is–F, –Cl, –Br, or –I.
  • R 2 is –F.
  • R 2 is –Cl.
  • R 2 is –Br.
  • R 2 is –CN.
  • R 2 is –NO 2 .
  • R 2 is –N 3 .
  • R 2 is –SF 5 .
  • R 2 is–OR A , wherein R A is as defined herein.
  • R 2 is –OCH 3 , –OCH 2 CH 3 , –OCH 2 CH 2 CH 3 , –OCH (CH 3 ) 2 , –OCH 2 F, –OCHF 2 , –OCF 3 , –OCH 2 CH 2 F, –OCH 2 CHF 2 , –OCF 2 CH 3 , –OCH 2 CF 3 , –OCH 2 CN, or –OCH 2 CONH 2 .
  • R 2 is –SR A , wherein R A is as defined herein.
  • R 2 is –SCH 3 .
  • R 2 is –SCH 2 CH 3 .
  • R 2 is –C (O) R B , wherein R B is as defined herein. In certain embodiments, R 2 is –C (O) NR C R D , wherein R C and R D are each as defined herein. In certain embodiments, R 2 is –C (O) OR A , wherein R A is as defined herein. In certain embodiments, R 2 is –OC (O) R B , wherein R B is as defined herein. In certain embodiments, R 2 is –NR C R D , wherein R C and R D are each as defined herein. In certain embodiments, R 2 is –NR C C (O) R B , wherein R B and R C are each as defined herein.
  • R 2 is –S (O) R B , wherein R B is as defined herein. In certain embodiments, R 2 is –S (O) 2 R B , wherein R B is as defined herein. In certain embodiments, R 2 is –S (O) NR C R D , wherein R C and R D are each as defined herein. In certain embodiments, R 2 is – NR C S (O) 2 R D , wherein R C and R D are each as defined herein. In certain embodiments, R 2 is –S (O) 2 NR C R D , wherein R C and R D are each as defined herein.
  • R 2 is –SiR G R H R I , wherein R G , R H , and R I are each as defined herein.
  • R 2 is –B (OR E ) (OR F ) , wherein R E and R F are each as defined herein.
  • R 2 is –P (O) R E R F , wherein R E and R F are each as defined herein.
  • R 2 is –P (O) OR E OR F , wherein R E and R F are each as defined herein.
  • R 2 is –OP (O) OR E OR F , wherein R E and R F are each as defined herein.
  • R 2 is C 1 -C 6 alkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 2A , wherein R 2A is as defined herein.
  • R 2 is C 1 -C 6 alkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, halo, –CN, –OH, –NH 2 , –NO 2 , –N 3 , oxo, –OC 1 -C 6 alkyl, –OC 1 -C 6 haloalkyl, –NHC 1 -C 3 alkyl, or –N (C 1- C 3 alkyl) 2 .
  • R 2 is –CD 3 , –CH 3 , –CH 2 CH 3 , n-propyl, i-propyl, n-butyl, i-butyl, t-butyl, –CH 2 F, –CHF 2 , –CF 3 , –CH 2 CH 2 F, –CH 2 CHF 2 , –CH 2 CF 3 , –CH 2 OH, –CH (OH) CH 3 , –CH 2 CH 2 OH, –CH 2 OCH 3 , –CH 2 OCHF 2 , –CH 2 OCH 2 F, –CH 2 OCF 3 , –CH (OCH 3 ) CH 3 , –CH 2 CH 2 NH 2 , –CH (NH 2 ) CH 3 , –CH 2 N (CH 3 ) 2 , –CH 2 CH 2 N (CH 3 ) 2 , or –CH 2 CN.
  • R 2 is C 2 alkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, halo, –CN, –OH, –N 3 , –OC 1 -C 6 alkyl, C 1 -C 6 haloalkyl, –OC 1 -C 6 haloalkyl, C 3 -C 6 cycloalkyl, or 4-6 membered heterocycloalkyl; wherein the cycloalkyl and heterocycloalkyl are each optionally substituted with D, halo, –CN, –OH, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, –O-C 1 -C 6 alkyl, or –O-C 1 -C 6 haloalkyl.
  • R 2 is C 1 alkyl optionally substituted with 1, 2, or 3 substituents, each of which is independently D, halo, –CN, –OH, –N 3 , –OC 1 -C 6 alkyl, C 1 -C 6 haloalkyl, –OC 1 -C 6 haloalkyl, C 3 -C 6 cycloalkyl, or 4-6 membered heterocycloalkyl; wherein the cycloalkyl and heterocycloalkyl are each optionally substituted with D, halo, –CN, –OH, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, –O-C 1 -C 6 alkyl, or –O-C 1 -C 6 haloalkyl.
  • R 2 is C 2 -C 6 alkenyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 2A , wherein R 2A is as defined herein.
  • R 2 is C 2 -C 6 alkynyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 2A , wherein R 2A is as defined herein.
  • R 2 is –C ⁇ CH or –C ⁇ CCH 3 .
  • R 2 is C 3 -C 6 cycloalkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 2A , wherein R 2A is as defined herein.
  • R 2 is cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl, each of which is optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 2A , wherein R 2A is as defined herein.
  • R 2 is 4-6 membered heterocycloalkyl having 1 or 2 heteroatoms, each independently selected from the group consisting of N, O, S, Si, and B, wherein each heteroatom is optionally substituted by one or more oxo, wherein the heterocycloalkyl is optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 2A , and wherein R 2A is as defined herein.
  • R 2 is azetidinyl, oxetanyl, thietanyl, pyrrolidinyl, tetrahydrofuranyl, tetrahydrothiophenyl, piperidinyl, tetrahydropyranyl, tetrahydrothiopyranyl, piperazinyl, morpholinyl, 1, 4-diazocanyl, 1, 4-diazepanyl, or azepanyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 2A , wherein R 2A is as defined herein.
  • R 2 is phenyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 2A , wherein R 2A is as defined herein.
  • R 2 is 5-6 membered heteroaryl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 2A , wherein R 2A is as defined herein.
  • each R 2 is independently (i) H, D, halo, or –OR A ; or (ii) C 1 -C 6 alkyl, optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 2A ; wherein R A and R 2A are each as defined herein.
  • each R 2 is independently H, –F, –Cl, –CH 3 , –CF 3 , or –OCH 3 .
  • one of the R 2 groups is –F. In certain embodiments, one of the R 2 groups is –Cl, –CH 3 , or –CF 3 . In certain embodiments, one of the R 2 groups is –OCH 3 .
  • three of the R 2 groups are not H. In certain embodiments, three of the R 2 groups are not H; the first of the three is –F; the second of the three is –Cl, –CH 3 , or –CF 3 ; and the third of the three is –OCH 3 . In certain embodiments, three of the R 2 groups are not H; the first of the three is –F; the second of the three is –Cl; and the third of the three is –OCH 3 .
  • each R 2A is independently D, halo, –CN, –OH, –NH 2 , –NO 2 , –N 3 , oxo, C 1 -C 6 alkyl, –OC 1 -C 6 alkyl, C 1 -C 6 haloalkyl, –OC 1 -C 6 haloalkyl, –NHC 1 -C 3 alkyl, –N (C 1 -C 3 alkyl) 2 , C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl, or 4-6 membered heterocycloalkyl; wherein the alkyl, alkenyl, alkynyl, cycloalkyl, and heterocycloalkyl are each optionally substituted with D, halo, –CN, –OH, –NH 2 , C 1 -C 6 alkyl, C 1 -C 6 halo
  • R 2A is D. In certain embodiments, R 2A is halo. In certain embodiments, R 2A is –F, –Cl, –Br, or –I. In certain embodiments, R 2A is –CN. In certain embodiments, R 2A is –OH. In certain embodiments, R 2A is –NH 2 . In certain embodiments, R 2A is –NO 2 . In certain embodiments, R 2A is –N 3 . In certain embodiments, R 2A is oxo.
  • two R 2 when on adjacent ring vertices, together with the carbon atom (s) to which they are attached form C 4 -C 7 cycloalkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 2B , wherein R 2B is as defined herein.
  • two R 2 when on adjacent ring vertices, together with the carbon atom to which they are attached form 4-7 membered heterocycloalkyl optionally substituted with 1, 2, 3, 4 or 5 substituents, each of which is independently R 2B , wherein R 2B is as defined herein.
  • each R 2B is independently D, halo, oxo, –CN, –OH, –NH 2 , –NO 2 , C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, –O-C 1 -C 6 alkyl, or –O-C 1 -C 6 haloalkyl.
  • R 2B is D.
  • R 2B is halo.
  • R 2B is –F, –Cl, –Br, or –I.
  • R 2B is oxo.
  • R 2B is –CN.
  • R 2B is –OH.
  • R 2B is –NH 2 . In certain embodiments, R 2B is –NO 2 . In certain embodiments, R 2B is C 1 -C 6 alkyl. In certain embodiments, R 2B is C 1 -C 6 haloalkyl. In certain embodiments, R 2B is –O-C 1 -C 6 alkyl. In certain embodiments, R 2B is –O-C 1 -C 6 haloalkyl.
  • each X 1 , X 2 , X 3 , and X 4 is independently N or CR 1 ;
  • each X 5 is independently NR 1 , O or S;
  • each Cy, R 1 , R 2 , R 3 , and m is as defined herein.
  • Y 1 , Y 2 , Y 3 , Y 4 , and Y 5 are each independently N or CR 2 ; and ring A, R 1 , R 2 , R 3 , and n are each as defined herein.
  • each ring A, R 1 , R 2 , R 3 , and n is as defined herein.
  • R 3 is H, D, –CN, halo, –NO 2 , –N 3 , –SF 5 , –B (OR 5 ) (OR 6 ) , –SiR 5 R 6 R 7 , –SR 8 , –S (O) R 8 , –S (O) 2 R 8 , –NR 9 R 10 , –NR 9 C (O) R 8 , –C (O) R 8 , –S (O) NR 9 R 10 , –S (O) 2 NR 9 R 10 , C 1 -C 8 alkyl, C 2 -C 8 alkenyl, or C 2 -C 8 alkynyl; wherein the alkyl, alkenyl, and alkynyl are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 substituents, each of which is independently R 4 ; wherein each R 4 , R 5 , R 6 , R 7 , R 8 , R 9
  • R 3 is H, D, –CN, halo, –NO 2 , –N 3 , –SF 5 , –B (OR 5 ) (OR 6 ) , –SiR 5 R 6 R 7 , –SR 8 , –S (O) R 8 , –S (O) 2 R 8 , –NR 9 R 10 , –NR 9 C (O) R 8 , –C (O) R 8 , –S (O) NR 9 R 10 , or –S (O) 2 NR 9 R 10 , wherein each R 5 , R 6 , R 7 , R 8 , R 9 , and R 10 is as defined herein.
  • R 3 is –B (OR 5 ) (OR 6 ) , –SiR 5 R 6 R 7 , –SR 8 , –S (O) R 8 , –S (O) 2 R 8 , –NR 9 R 10 , –NR 9 C (O) R 8 , –C (O) R 8 , –S (O) NR 9 R 10 , or –S (O) 2 NR 9 R 10 , wherein each R 5 , R 6 , R 7 , R 8 , R 9 , and R 10 is as defined herein.
  • R 3 is –B (OR 5 ) (OR 6 ) , wherein R 5 and R 6 are each as defined herein.
  • each R 5 and R 6 is independently H, D, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 3 -C 7 cycloalkyl, 4-7 membered heterocycloalkyl, or phenyl; wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, and phenyl are each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, halo, –CN, –NO 2 , –N 3 , oxo, –NR C R D , –OR A , –SR A , –SiR G R H R I , –C (O) R B , –C (O) NR C R D , –OC (O) NR C R D , –NR C C (O) R B , –NR C C (O)
  • R 3 is –SiR 5 R 6 R 7 , wherein R 5 , R 6 , and R 7 are each as defined herein.
  • each R 5 , R 6 , and R 7 is independently H, D, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 3 -C 7 cycloalkyl, 4-7 membered heterocycloalkyl, or phenyl; wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, and phenyl are each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, halo, –CN, –NO 2 , –N 3 , oxo, –NR C R D , –OR A , –SR A , –SiR G R H R I , –C (O) R B , –C (O) NR C R D , –OC (O) NR C R D , –NR C C (O) R B , –
  • R 5 , R 6 , and R 7 are each independently C 1 -C 8 alkyl. In certain embodiments, R 5 , R 6 , and R 7 are each methyl.
  • R 3 is –SR 8 , wherein R 8 is as defined herein.
  • R 8 is C 1 -C 8 alkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 8A , wherein R 8A is as defined herein.
  • R 8 is methyl, ethyl, propyl, butyl, pentyl, or hexyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 8A , wherein R 8A is as defined herein.
  • R 8 is methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, t-butyl, —CH 2 C (CH 3 ) 3 , –CH 2 F, –CHF 2 , –CF 3 , –CH 2 CH 2 F, –CH 2 CHF 2 , –CH 2 CF 3 , –CH 2 CN, –CH 2 CH 2 CN, –CH 2 CH 2 CH 2 CN, –CH (CH 3 ) CN, –C (CH 3 ) 2 CN, –CH 2 C (CH 3 ) 2 CN, –CH 2 CH 2 OH, –CH 2 CH 2 OCH 3 , –CH 2 CH 2 OCF 3 , –CH 2 CH 2 OCH 2 CH 3 , –CH 2 CH 2 CH 2 OH, –CH 2 CH 2 C (CH 3 ) 2 OH, –CH (CH 3 ) CH 2 CH 2 OH
  • R 8 is C 2 -C 8 alkenyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 8A , wherein R 8A is as defined herein.
  • R 8 is C 2 -C 8 alkynyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 8A , wherein R 8A is as defined herein.
  • R 8 is C 3 -C 10 cycloalkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 8A , wherein R 8A is as defined herein.
  • R 8 is cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopentenyl, cyclopentadienyl, or cyclohexenyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 8A , wherein R 8A is as defined herein. In certain embodiments, R 8 is
  • R 8 is 4-10 membered heterocycloalkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 8A , wherein R 8A is as defined herein.
  • R 8 is azetidinyl, oxetanyl, thietanyl, pyrrolidinyl, tetrahydrofuranyl, tetrahydrothio-phenyl, piperidinyl, dioxanyl, tetrahydropyranyl, tetrahydrothiopyranyl, piperazinyl, or morpholinyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 8A , wherein R 8A is as defined herein.
  • R 8 is C 6 -C 10 aryl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 8A , wherein R 8A is as defined herein.
  • R 8 is phenyl or naphthyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 8A , wherein R 8A is as defined herein.
  • R 8 is 5-10 membered heteroaryl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 8A , wherein R 8A is as defined herein.
  • R 8 is pyrrolyl, furanyl, thiophenyl, imidazolyl, oxazolyl, thiazolyl, tetrazolyl, pyrazolyl, triazolyl, thiadiazolyl, oxadiazolyl, pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, indolyl, isoindolyl, indolizinyl, benzofuranyl, isobenzofuranyl, benzo [b] thiophenyl, benzo [c] thiophenyl, indazolyl, benzo [d] imidazolyl, pyrrolo [3, 2-b] pyridinyl, pyrrol
  • R 8 is C 1 -C 8 alkyl or C 3 -C 10 cycloalkyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 8A , wherein R 8A is as defined herein.
  • R 8 is –CH 2 CH 3 , –CH 2 CF 3 , –CH 2 CH 2 OH, –CH 2 CH (CH 3 ) OH, –CH (CH 3 ) CH 2 OH, –CH 2 CH 2 OCH 3 , –CH 2 CH 2 CH 2 CN, –CH 2 CH 2 CH 2 OH, –CH 2 CH 2 C (CH 3 ) 2 OH, – CH (CH 3 ) CO 2 H, –CH (CH 3 ) CO 2 CH 2 CH 3 , –CH 2 CH 2 OSi (CH 3 ) 2 C (CH 3 ) 3 , or 2-hydroxycyclopentyl.
  • R 3 is –S (O) R 8 , wherein R 8 is as defined herein.
  • a compound of Formula (VIIa) , (VIIb) , (VIIc) , (VIId) , or (VIIe) is provided herein.
  • R 3 is –S (O) 2 R 8 , wherein R 8 is as defined herein.
  • R 3 is –NR 9 R 10 , wherein R 9 and R 10 are each as defined herein.
  • R 9 is H. In certain embodiments, R 9 is D. In certain embodiments, R 9 is C 1 -C 6 alkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –OH, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, –OC 1 -C 4 alkyl, –OC 1 -C 4 haloalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 haloalkyl, –SF 5 , –OC (O) NR c R d , –NR c R d , –NR c C (O) R b , –S (O) NR c R d , –S (O) 2 R
  • R 9 is –CH 3 , –CH 2 CH 3 , –CH 2 CH 2 CH 3 , —CH (CH 3 ) 2 , –CH 2 CH 2 CH 2 CH 3 , –CH 2 CH (CH 3 ) 2 , or –C (CH 3 ) 3 .
  • R 9 is C 3 -C 7 cycloalkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –OH, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, –OC 1 -C 4 alkyl, –OC 1 -C 4 haloalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 haloalkyl, –SF 5 , –OC (O) NR c R d , –NR c R d , –NR c C (O) R b , –S (O) NR c R d , –S (O) 2 R b , –NR c S (O) 2 R b
  • R 10 is H. In certain embodiments, R 10 is D. In certain embodiments, R 10 is C 1 -C 6 alkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –OH, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, –OC 1 -C 4 alkyl, –OC 1 -C 4 haloalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 haloalkyl, –OC (O) NR c R d , –NR c R d , –NR c C (O) R b , –S (O) NR c R d , –S (O) 2 R b , –NR
  • R 10 is –CH 3 , –CH 2 CH 3 , –CH 2 CH 2 CH 3 , —CH (CH 3 ) 2 , –CH 2 CH 2 CH 2 CH 3 , –CH 2 CH (CH 3 ) 2 , –C (CH 3 ) 3 , –CH 2 CF 3 , –CH 2 CH 2 OH, –CH 2 CH 2 OCH 3 , –CH 2 CH 2 OCH 2 CH 2 OH, –CH 2 CH 2 CN, –CH 2 CH 2 N (CH 3 ) C (O) CH 3 , –CH 2 CH 2 N (CH 3 ) S (O) 2 CH 3 , or –CH 2 CH 2 N (CH 3 ) S (O) 2 N (CH 3 ) 2 .
  • R 10 is C 2 -C 6 alkenyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –OH, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, –OC 1 -C 4 alkyl, –OC 1 -C 4 haloalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 haloalkyl, –OC (O) NR c R d , –NR c R d , –NR c C (O) R b , –S (O) NR c R d , –S (O) 2 R b , –NR c S (O) 2 R b , –S (O) 2
  • R 10 is C 2 -C 6 alkynyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –OH, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, ––OC 1 -C 4 alkyl, OC 1 -C 4 haloalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 haloalkyl, –OC (O) NR c R d , –NR c R d , –NR c C (O) R b , –S (O) NR c R d , –S (O) 2 R b , –NR c S (O) 2 R b , –S (O)
  • R 10 is C 3 -C 7 cycloalkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which independently D, –OH, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, –OC 1 -C 4 alkyl, –OC 1 -C 4 haloalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 haloalkyl, –OC (O) NR c R d , –NR c R d , –NR c C (O) R b , –S (O) NR c R d , –S (O) 2 R b , –NR c S (O) 2 R b , –S (O)
  • R 10 is cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which independently D, –OH, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, –OC 1 -C 4 alkyl, –OC 1 -C 4 haloalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 haloalkyl, –OC (O) NR c R d , –NR c R d , –NR c C (O) R b , –S (O) NR c R d , –S (O) 2 R b , – –
  • R 10 is 4-7 membered heterocycloalkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which independently D, –OH, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, –OC 1 -C 4 alkyl, –OC 1 -C 4 haloalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 haloalkyl, –OC (O) NR c R d , –NR c R d , –NR c C (O) R b , –S (O) NR c R d , –S (O) 2 R b , –NR c S (O) 2 R b , –S (O) 2
  • R 10 is azetidinyl, oxetanyl, pyrrolidinyl, tetrahydrofuranyl, tetrahydrothiophenyl, piperidinyl, dioxanyl, tetrahydropyranyl, piperazinyl, or morpholinyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which independently D, –OH, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, –OC 1 -C 4 alkyl, –OC 1 -C 4 haloalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 haloalkyl, –OC (O) NR c R d ,
  • R 10 is phenyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which independently D, –OH, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, –OC 1 -C 4 alkyl, –OC 1 -C 4 haloalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 haloalkyl, –OC (O) NR c R d , –NR c R d , –NR c C (O) R b , –S (O) NR c R d , –S (O) 2 R b , –NR c S (O) 2 R b , –S (O) 2 NR c R d
  • R 10 is 5-6 membered heteroaryl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which independently D, –OH, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, –OC 1 -C 4 alkyl, –OC 1 -C 4 haloalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 haloalkyl, –OC (O) NR c R d , –NR c R d , –NR c C (O) R b , –S (O) NR c R d , –S (O) 2 R b , –NR c S (O) 2 R b , –S (O) 2 NR NR ,
  • R 10 is pyrrolyl, furanyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, pyrazolyl, 1, 2, 3-triazolyl, thiadiazolyl, oxadiazolyl, pyridinyl, pyrimidinyl, pyrazinyl, or pyridazinyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which independently D, –OH, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, –OC 1 -C 4 alkyl, –OC 1 -C 4 haloalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 haloalkyl, –
  • R 10 is arylalkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which independently D, –OH, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, –OC 1 -C 4 alkyl, –OC 1 -C 4 haloalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 haloalkyl, –OC (O) NR c R d , –NR c R d , –NR c C (O) R b , –S (O) NR c R d , –S (O) 2 R b , –NR c S (O) 2 R b , –S (O) 2 NR c R
  • R 10 is heteroarylalkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which independently D, –OH, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, –OC 1 -C 4 alkyl, –OC 1 -C 4 haloalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 haloalkyl, –OC (O) NR c R d , –NR c R d , –NR c C (O) R b , –S (O) NR c R d , –S (O) 2 R b , –NR c S (O) 2 R b , –S (O) 2 NR c R
  • R 10 is cycloalkylalkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which independently D, –OH, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, –OC 1 -C 4 alkyl, –OC 1 -C 4 haloalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 haloalkyl, –OC (O) NR c R d , –NR c R d , –NR c C (O) R b , –S (O) NR c R d , –S (O) 2 R b , –NR c S (O) 2 R b , –S (O) 2 NR
  • R 10 is heterocycloalkylalkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which independently D, –OH, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, –OC 1 -C 4 alkyl, –OC 1 -C 4 haloalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 haloalkyl, –OC (O) NR c R d , –NR c R d , –NR c C (O) R b , –S (O) NR c R d , –S (O) 2 R b , –NR c S (O) 2 R b , –S (O) 2 NR , –
  • R 3 is –NR 9 C (O) R 8 , wherein R 8 and R 9 are each as defined herein. In certain embodiments, R 3 is –C (O) R 8 , wherein R 8 is as defined herein. In certain embodiments, R 3 is –S (O) NR 9 R 10 , wherein R 9 and R 10 are each as defined herein. In certain embodiments, R 3 is –S (O) 2 NR 9 R 10 , wherein R 9 and R 10 are each as defined herein.
  • R 3 is C 1 -C 8 alkyl, C 2 -C 8 alkenyl, or C 2 -C 8 alkynyl, each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 substituents, each of which is independently R 4 , wherein R 4 is as defined herein.
  • each Y 3 , R 1 , R 2 , R 3 , and R 4 is as defined herein.
  • Y 3 is CR 2 or N, wherein R 2 is as defined herein. In certain embodiments, Y 3 is CR 2 , wherein R 2 is as defined herein. In certain embodiments, Y 3 is CH. In certain embodiments, Y 3 is N.
  • the moiety has the structure of
  • the moiety has the structure of
  • R 3 is C 1 -C 8 alkyl optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 substituents, each of which is independently R 4 , wherein R 4 is as defined herein.
  • R 3 is methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, t-butyl, —CH 2 C (CH 3 ) 3 , –CH 2 F, –CHF 2 , –CF 3 , –CH 2 CH 2 F, –CH 2 CHF 2 , –CH 2 CF 3 , —CH (CH 3 ) F, –C (CH 3 ) 2 F, –CH 2 CH (CH 3 ) F, –CH 2 C (CH 3 ) 2 F, –CF 2 CH 3 , –CF 2 CH 2 CH 3 , –CF 2 CH (CH 3 ) 2 , –CF 2 CH (CH 3 ) 2 , –CF 2 CH (CH 3
  • R 3 is straight-chained or branched C 1 -C 8 alkyl, each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 substituents, each of which is independently R 4 ; wherein one of R 4 is –OR A1 ; and wherein R 4 and R A1 are each as defined herein.
  • R 3 is straight-chained or branched C 1 -C 3 alkyl, each optionally substituted with 1, 2, 3, 4, 5, or 6 substituents, each of which is independently R 4 ; wherein one of R 4 is –OR A1 ; and wherein R 4 and R A1 are each as defined herein.
  • R 3 is wherein each R 4 and R A1 is as defined herein.
  • each Y 3 , R 1 , R 2 , R 4 , R A1 , and m is as defined herein.
  • Y 3 is CR 2 or N, wherein R 2 is as defined herein. In certain embodiments, Y 3 is CR 2 , wherein R 2 is as defined herein. In certain embodiments, Y 3 is CH. In certain embodiments, Y 3 is N.
  • each R 4 is independently H, D, halo, –NO 2 , –N 3 , oxo, or C 1 -C 4 alkyl.
  • one of R 4 is D.
  • one of R 4 is halo.
  • one of R 4 is –F, –Cl, –Br, or –I.
  • one of R 4 is –F.
  • two of R 4 are –F.
  • one of R 4 is –CN.
  • one of R 4 is –NO 2 .
  • one of R 4 is –N 3 .
  • two R 4 together with the carbon atom to which they are attached form oxo.
  • one of R 4 is C 1 -C 4 alkyl.
  • one of R 4 is methyl.
  • R A1 is H. In certain embodiments, R A1 is D. In certain embodiments, R A1 is C 1 -C 8 alkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 11 , wherein R 11 is as defined herein. In certain embodiments, R A1 is methyl, ethyl, propyl, butyl, pentyl, or hexyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 11 , wherein R 11 is as defined herein.
  • R A1 is H, D, methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, t-butyl, —CH 2 C (CH 3 ) 3 , –CH 2 F, –CHF 2 , –CF 3 , –CH 2 CH 2 F, –CH 2 CHF 2 , –CH 2 CF 3 , –CH 2 CH 2 OH, –CH 2 CH (CH 3 ) OH, –CH 2 CH 2 OCH 3 , – CH 2 CH 2 OCH 2 CH 3 , –CH 2 CH 2 OCH 2 CH 2 OH, –CH 2 CH 2 OCH 2 CH 2 OCH 3 , –CH 2 CH 2 OCH 2 CH 2 OCH 3 , –CH 2 CH 2 OCH 2 CH 2 OCH 3 , –CH 2 CH 2 OCH 2 CH 2 OCH 2 CH 3 , –CH 2 CH 2 SCH 3 , –CH 2 CH 2
  • R A1 is C 2 -C 8 alkenyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 11 , wherein R 11 is as defined herein.
  • R A1 is C 2 -C 8 alkynyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 11 , wherein R 11 is as defined herein.
  • R 3 is straight-chained or branched C 1 -C 8 alkyl, each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 substituents independently selected from R 4 ; and one of R 4 is OR A2 ; wherein R 4 and R A2 are each as defined herein.
  • R 3 is straight-chained or branched C 1 -C 3 alkyl optionally substituted with 1, 2, 3, 4, 5 or 6 substituents independently selected from R 4 ; and one of R 4 is OR A2 ; wherein R 4 and R A2 are each as defined herein.
  • R 3 is wherein each R 4 and R A2 is as defined herein.
  • each Cy, R 1 , R 2 , R 4 , R A2 , and m is as defined herein, with the proviso that, when R A2 is C 6 -C 14 aryl or 5-14 membered heteroaryl, at least one of R 4 is not H.
  • each R 4 is independently H, D, halo, –CN, –NO 2 , –N 3 , oxo, or C 1 -C 4 alkyl, with the proviso that, when R A2 is C 6 -C 14 aryl or 5-14 membered heteroaryl, at least one of R 4 is not H.
  • one of R 4 is D. In certain embodiments, one of R 4 is halo. In certain embodiments, one of R 4 is –F, –Cl, –Br, or –I. In certain embodiments, one of R 4 is –F. In certain embodiments, two of R 4 are –F. In certain embodiments, one of R 4 is –CN. In certain embodiments, one of R 4 is –NO 2 . In certain embodiments, one of R 4 is –N 3 . In certain embodiments, two R 4 together with the carbon atom to which they are attached form oxo. In certain embodiments, one of R 4 is C 1 -C 4 alkyl. In certain embodiments, one of R 4 is methyl.
  • R A2 is C 3 -C 14 cycloalkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 12 ; wherein R 12 is as defined herein.
  • R A2 is saturated C 3 -C 14 cycloalkyl or partially unsaturated C 3 -C 14 cycloalkyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 12 ; wherein R 12 is as defined herein.
  • R A2 is cyclopropanyl, cyclobutenyl, cyclopentanyl, cyclohexanyl, cycloheptanyl, spiro [3.3] heptanyl, spiro [3.4] octanyl, spiro [3.5] nonanyl, spiro [3.6] decanyl, spiro [4.4] nonanyl, spiro [4.5] decanyl, spiro [4.6] undecanyl, spiro [5.6] dodecanyl, spiro [6.6] tridecanyl, bicyclo [2.2.0] hexanyl, bicyclo [3.2.0] heptanyl, bicyclo [4.2.0] octanyl, bicyclo [5.2.0] nonanyl, octahydropentalenyl, octahydro-1H-indenyl, decahydroazulenyl, decahydronaphth
  • R A2 is cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 12 ; wherein R 12 is as defined herein.
  • R 3 is wherein each R 4 and R 12 is as defined herein.
  • R A2 is saturated 4-14 membered heterocycloalkyl or partially unsaturated 4-14 membered heterocycloalkyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 12 ; wherein R 12 is as defined herein.
  • R A2 is azetidinyl, oxetanyl, thietanyl, pyrrolidinyl, tetrahydrofuranyl, tetrahydro-thiophenyl, piperidinyl, tetrahydropyranyl, tetrahydrothiopyranyl, piperazinyl, morpholinyl, 1, 4-diazocanyl, 1, 4-diazepanyl, azepanyl, 2, 6-diazaspiro [3.3] heptanyl, 2-oxa-6-azaspiro [3.3] heptanyl, 2, 6-diazaspiro [3.4] octanyl, 2, 7-diazaspiro [3.5] nonanyl, 2, 7-diazaspiro [4.4] nonanyl, 3, 9-diazaspiro-[5.5] undecanyl, 2-oxa-7-azaspiro [3.5] nonanyl, 2-oxa
  • R A2 is azetidinyl, oxetanyl, thietanyl, pyrrolidinyl, tetrahydrofuranyl, tetrahydrothiophenyl, piperidinyl, tetrahydropyranyl, tetrahydrothiopyranyl, piperazinyl, morpholinyl, 1, 4-diazocanyl, 1, 4-diazepanyl, azepanyl, or 2, 6-diazaspiro [3.3] heptanyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 12 ; wherein R 12 is as defined herein.
  • R 3 is wherein each R 4 and R 12 is as defined herein.
  • at least one of R 4 is not H; and R A2 is C 6 -C 14 aryl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 12 ; wherein R 12 is as defined herein.
  • at least one of R 4 is not H; and R A2 is phenyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 12 ; wherein R 12 is as defined herein.
  • R 3 is wherein each R 4 and R 12 is as defined herein, with the proviso that at least one of R 4 is not H.
  • R A2 is 5-14 membered heteroaryl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 12 ; wherein R 12 is as defined herein; with the proviso that at least one of R 4 is not H.
  • R A2 is pyrrolyl, furanyl, thiophenyl, imidazolyl, oxazolyl, thiazolyl, tetrazolyl, pyrazolyl, triazolyl, 1, 2, 4-triazolyl, 1, 2, 3-triazolyl, thiadiazolyl, oxadiazolyl, pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, indolyl, isoindolyl, indolizinyl, benzofuranyl, isobenzofuranyl, benzo [b] thiophenyl, benzo [c] thiophenyl, indazolyl, benzo [d] imidazolyl, pyrrolo [3, 2-b] pyridinyl, pyrrolo [3, 2-c] pyridinyl, pyrrolo [2, 3-c] pyridinyl, pyrrolo [2,
  • R A2 is pyrrolyl, furanyl, thiophenyl, imidazolyl, oxazolyl, thiazolyl, tetrazolyl, pyrazolyl, triazolyl, thiadiazolyl, oxadiazolyl, pyridinyl, pyrimidinyl, pyrazinyl, or pyridazinyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 12 ; wherein R 12 is as defined herein; with the proviso that at least one of R 4 is not H.
  • R 3 is
  • each R 4 and R 12 is as defined herein; with the proviso that at least one of R 4 is not H.
  • R 3 is straight-chained or branched C 1 -C 8 alkyl, each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 substituents, each of which is independently R 4 ; with the proviso that one of R 4 is –C (O) R B ; wherein R 4 and R B are each as defined herein.
  • R 3 is straight-chained or branched C 1 -C 3 alkyl, optionally substituted with 1, 2, 3, 4, 5, or 6 substituents, each of which is independently R 4 ; with the proviso that one of R 4 is –C (O) R B ; wherein R 4 and R B are each as defined herein.
  • R 3 is wherein each R 4 and R B is as defined herein; with the proviso that one of R 4 is –C (O) R B .
  • each R 4 is independently H, D, halo, –CN, NO 2 , –N 3 , oxo, or C 1 -C 4 alkyl, with the proviso that at least one of R 4 is not H; and each Cy, R 1 , R 2 , R B , and m is as defined herein.
  • one of R 4 is D. In certain embodiments, one of R 4 is halo. In certain embodiments, one of R 4 is –F, –Cl, –Br, or –I. In certain embodiments, one of R 4 is –F. In certain embodiments, two of R 4 are –F. In certain embodiments, one of R 4 is –CN. In certain embodiments, one of R 4 is –NO 2 . In certain embodiments, one of R 4 is –N 3 . In certain embodiments, two R 4 together with the carbon atom to which they are attached form oxo. In certain embodiments, one of R 4 is C 1 -C 4 alkyl. In certain embodiments, one of R 4 is methyl.
  • R B is C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6 -C 10 aryl, 5-10 membered heteroaryl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R B1 ; wherein R B1 is as defined herein.
  • R B is C 1 -C 6 alkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R B1 ; wherein R B1 is as defined herein.
  • R B is methyl, ethyl, or propyl, each optionally substituted with 1, 2, 3, 4 or 5 substituents, each of which is independently R B1 ; wherein R B1 is as defined herein.
  • R B is C 2 -C 6 alkenyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R B1 ; wherein R B1 is as defined herein.
  • R B is C 2 -C 6 alkynyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R B1 ; wherein R B1 is as defined herein.
  • R B is C 3 -C 10 cycloalkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R B1 ; wherein R B1 is as defined herein.
  • R B is cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, or spiro [3.3] heptanyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R B1 ; wherein R B1 is as defined herein.
  • R B is 4-10 membered heterocycloalkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R B1 ; wherein R B1 is as defined herein.
  • R B is saturated 4-10 membered heterocycloalkyl or partially unsaturated 4-10 membered heterocycloalkyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R B1 ; wherein R B1 is as defined herein.
  • R B is azetidinyl, oxetanyl, pyrrolidinyl, tetrahydrofuranyl, piperidinyl, dioxanyl, piperazinyl, morpholinyl, azepanyl, diazocanyl, 1, 4-diazepanyl, 4-oxa-7-azaspiro [2.5] -octanyl, 2, 6-diazaspiro [3.3] heptanyl, 2, 6-diazaspiro [3.4] octanyl, 2, 7-diazaspiro [3.5] nonanyl, 1, 8-diazaspiro [4.5] decanyl, octahydropyrrolo [3, 2-b] pyridinyl, hexahydropyrrolo [1, 2-a] imidazolyl, 2-oxa-5-azabicyclo [2.2.1] heptanyl, octahydropyrrolo [1, 2-a]
  • R B is pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, 1, 4-diazepanyl, 4-oxa-7-azaspiro [2.5] octanyl, 1, 8-diazaspiro [4.5] decanyl, 2-oxa-5-azabicyclo [2.2.1] heptanyl, octahydropyrrolo [1, 2-a] pyrazinyl, hexahydropyrrolo- [1, 2-a] -pyrazinyl, 5, 6, 7, 8-tetrahydro [1, 2, 4] -triazolo [4, 3-a] pyrazinyl, or octahydropyrazino [2, 1-c] [1, 4] -oxazinyl, each optionally substituted with 1, 2, or 3 substituents, each of which is independently (i) cyano, –OR a , or –NR c R d ; or (
  • R B is pyrrolidin-1-yl, piperidin-1-yl, morpholin-4-yl, piperazin-1-yl, 1, 4-diazepan-1-yl, 4-oxa-7-azaspiro [2.5] octan-7-yl, 1, 8-diazaspiro [4.5] decan-8-yl, 2-oxa-5-azabicyclo [2.2.1] heptan-5-yl, octahydropyrrolo [1, 2-a] pyrazin-2-yl, hexahydropyrrolo- [1, 2-a] -pyrazin-2-yl, 5, 6, 7, 8-tetrahydro [1, 2, 4] triazolo [4, 3-a] pyrazin-7-yl, or octahydropyrazino [2, 1-c] [1, 4] -oxazin-8-yl, each optionally substituted with 1, 2, or 3 substituents, each of which is independently cyano
  • R B is 3-hydroxypyrrolidin-1-yl, 3-methoxy-pyrrolidin-1-yl, 3- (dimethylamino) pyrrolidin-1-yl, 4-cyanopiperidin-1-yl, 3-hydroxypiperidin-1-yl, 4-hydroxy-piperidin-1-yl, 4-methoxypiperidin-1-yl, morpholin-4-yl, 4-methylpiperazin-1-yl, 4-ethyl-piperazin-1-yl, 4- (2-hydroxyethyl) piperazin-1-yl, 4-methyl-1, 4-diazepan-1-yl, 4-oxa-7-azaspiro- [2.5] octan-7-yl, 1-ethyl-1, 8-diazaspiro [4.5] decan-8-yl, 2-oxa-5-azabicyclo [2.2.1] heptan-5-yl, octahydropyrrolo- [1, 2-a] pyrazin-2-yl
  • R 3 is –CF 2 CH 2 COCH 3 , wherein each R B1 is as defined herein.
  • R B is C 6 -C 10 aryl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R B1 ; wherein R B1 is as defined herein.
  • R B is phenyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R B1 ; wherein R B1 is as defined herein.
  • R B is 5-10 membered heteroaryl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R B1 ; wherein R B1 is as defined herein.
  • R B is pyrrolyl, furanyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, pyrazolyl, 1, 2, 3-triazolyl, thiadiazolyl, oxadiazolyl, pyridinyl, pyrimidinyl, pyrazinyl, or pyridazinyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R B1 ; wherein R B1 is as defined herein.
  • R B is arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R B1 ; wherein R B1 is as defined herein.
  • R 3 is straight-chained or branched C 1 -C 8 alkyl, each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 substituents, each of which is independently R 4 , with the proviso that one of R 4 is –C (O) NR C R D ; wherein R 4 , R C , and R D are each as defined herein.
  • R 3 is straight-chained or branched C 1 -C 3 alkyl, each optionally substituted with 1, 2, 3, 4, 5, or 6 substituents, each of which is independently R 4 , with the proviso that one of R 4 is –C (O) NR C R D ; wherein R 4 , R C , and R D are each as defined herein.
  • R 3 is wherein each R 4 , R C , and R D is as defined herein.
  • each R 4 is independently H, D, halo, –CN, –NO 2 , –N 3 , oxo, or C 1 -C 4 alkyl; with the proviso that at least one of R 4 is not H; and each Cy, R 1 , R 2 , R C , R D , and m are as defined herein.
  • one of R 4 is D. In certain embodiments, one of R 4 is halo. In certain embodiments, one of R 4 is –F, –Cl, –Br, or –I. In certain embodiments, one of R 4 is –F. In certain embodiments, two of R 4 are –F. In certain embodiments, one of R 4 is –CN. In certain embodiments, one of R 4 is –NO 2 . In certain embodiments, one of R 4 is –N 3 . In certain embodiments, two R 4 together with the carbon atom to which they are attached form oxo. In certain embodiments, one of R 4 is C 1 -C 4 alkyl. In certain embodiments, one of R 4 is methyl.
  • R C is (i) H, D, or –CN; or (ii) C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6 -C 10 aryl, 5-10 membered heteroaryl, C 6 -C 10 aryl-C 1 -C 6 alkyl, 5-10 membered heteroaryl-C 1 -C 6 alkyl, C 3 -C 10 cycloalkyl-C 1 -C 6 alkyl, or 4-10 membered heterocycloalkyl-C 1 -C 6 alkyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyano
  • R C is H, D, C 1 -C 6 alkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 haloalkyl, –SF 5 , –OR a , –OC (O) NR c R d , –NR c R d , –NR c C (O) R b , –S (O) NR c R d , –S (O) 2 R b , –NR c S (O) 2 R b , –S (O) 2 NR c R d , –NR c S (O) 2
  • R C is H, D, –CH 3 , –CH 2 CH 3 , –CH 2 CH 2 CH 3 , —CH (CH 3 ) 2 , –CH 2 CH 2 CH 2 CH 3 , –CH 2 CH (CH 3 ) 2 , or –C (CH 3 ) 3 .
  • R C is (i) H; or (ii) C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6 -C 10 aryl, 5-10 membered heteroaryl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 haloalkyl, –SF 5 ,
  • R C is (i) H; or (ii) C 1 -C 6 alkyl, C 3 -C 10 cycloalkyl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, cycloalkylalkyl, or heteroarylalkyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently cyano, halo, C 1 -C 4 alkyl, –OR a , or –NR c R d ; wherein each R a , R c , and R d is as defined herein.
  • R C is (i) H; or (ii) methyl, ethyl, propyl, cyclopropyl, cyclohexyl, tetrahydropyranyl, pyrazolyl, cyclopropylmethyl, or pyridinyl-methyl, each optionally substituted with 1, 2, or 3, substituents, each of which is independently cyano, fluoro, methyl, hydroxyl, methoxy, or dimethylamino.
  • R C is H, methyl, ethyl, 2-cyanoethyl, 2, 2, 2-trifluoroethyl, 2-hydroxyethyl, 2-methoxyethyl, 2-dimethylaminoethyl, isopropyl, 2-hydroxypropyl, 2-hydroxy-2-methylpropyl, 2-methoxy-2-methylpropyl, cyclopropyl, 4-hydroxy-cyclohexyl, tetrahydropyran-4-yl, 1-methylpyrazol-4-yl, (1-hydroxycyclopropyl) methyl, (1-methoxycyclopropyl) methyl, or pyridin-2-ylmethyl.
  • R C is H, methyl, or ethyl.
  • R D is independently (i) H, D, or –CN; or (ii) C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6 -C 10 aryl, 5-10 membered heteroaryl, C 6 -C 10 aryl-C 1 -C 6 alkyl, 5-10 membered heteroaryl-C 1 -C 6 alkyl, C 3 -C 10 cycloalkyl-C 1 -C 6 alkyl, or 4-10 membered heterocycloalkyl-C 1 -C 6 alkyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyan
  • R D is H. In certain embodiments, R D is D. In certain embodiments, R D is C 1 -C 6 alkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 haloalkyl, –SF 5 , –OR a , –OC (O) NR c R d , –NR c R d , –NR c C (O) R b , –S (O) NR c R d , –S (O) 2 R b , –NR c S (O) 2 R b , –S (O)
  • R D is –CH 3 , –CH 2 CH 3 , –CH 2 CH 2 CH 3 , —CH (CH 3 ) 2 , –CH 2 CH 2 CH 2 CH 3 , –CH 2 CH (CH 3 ) 2 , –C (CH 3 ) 3 , –CH 2 CF 3 , –CH 2 CH 2 OH, –CH 2 CH 2 OCH 3 , –CH (CH 3 ) CH 2 OH, –CH (CH 3 ) CH 2 OCH 3 , –CH 2 CH (CH 3 ) OH, –CH 2 CH (CH 3 ) OCH 3 , –CH 2 C (CH 3 ) 2 OH, –CH 2 C (CH 3 ) 2 OCH 3 , –CH 2 CH 2 NH 2 , –CH 2 CH 2 NH (CH 3 ) , –CH 2 CH 2 N (CH 3 ) 2 , –CH 2 CH 2 CN, –CH 2 CH 2 N (CH 3 ) 3 ,
  • R D is C 2 -C 6 alkenyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 haloalkyl, –SF 5 , –OR a , –OC (O) NR c R d , –NR c R d , –NR c C (O) R b , –S (O) NR c R d , –S (O) 2 R b , –NR c S (O) 2 R b , –S (O) 2 NR c R d , –NR c S (O) 2 R b
  • R D is C 2 -C 6 alkynyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 haloalkyl, –SF 5 , –OR a , –OC (O) NR c R d , –NR c R d , –NR c C (O) R b , –S (O) NR c R d , –S (O) 2 R b , –NR c S (O) 2 R b , –S (O) 2 NR c R d , –NR c S (O) 2 R
  • R D is C 3 -C 10 cycloalkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 haloalkyl, –SF 5 , –OR a , –OC (O) NR c R d , –NR c R d , –NR c C (O) R b , –S (O) NR c R d , –S (O) 2 R b , –NR c S (O) 2 R b , –S (O) 2 NR c R d , –NR c S (O) 2 R
  • R D is cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 haloalkyl, –SF 5 , –OR a , –OC (O) NR c R d , –NR c R d , –NR c C (O) R b , –S (O) NR c R d , –S (O) 2 R b , –NR c S (O) 2 R b , –S (O) (O
  • R D is 4-10 membered heterocycloalkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 haloalkyl, –SF 5 , –OR a , –OC (O) NR c R d , –NR c R d , –NR c C (O) R b , –S (O) NR c R d , –S (O) 2 R b , –NR c S (O) 2 R b , –S (O) 2 NR c R d , – NR c S (O) 2 R
  • R D is azetidinyl, oxetanyl, pyrrolidinyl, tetrahydrofuranyl, piperidinyl, dioxanyl, tetrahydropyranyl, piperazinyl, morpholinyl, azepanyl, diazocanyl, 1, 4-diazepanyl, 2, 6-diazaspiro [3.3] heptanyl, 6-diazaspiro [3.4] octanyl, or 2, 7-diazaspiro [3.5] nonanyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-
  • R D is C 6 -C 10 aryl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 haloalkyl, –SF 5 , –OR a , –OC (O) NR c R d , –NR c R d , –NR c C (O) R b , –S (O) NR c R d , –S (O) 2 R b , –NR c S (O) 2 R b , –S (O) 2 NR c R d , –NR c S (O) 2 b ,
  • R D is phenyl or naphthyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 haloalkyl, –SF 5 , –OR a , –OC (O) NR c R d , –NR c R d , –NR c C (O) R b , –S (O) NR c R d , –S (O) 2 R b , –NR c S (O) 2 R b , –S (O) 2 NR c R d , –NR c S (O) 2 R
  • R D is 5-10 membered heteroaryl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 haloalkyl, –SF 5 , –OR a , –OC (O) NR c R d , –NR c R d , –NR c C (O) R b , –S (O) NR c R d , –S (O) 2 R b , –NR c S (O) 2 R b , –S (O) 2 NR c R d , –NR c S (O) 2 b ,
  • R D is pyrrolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, tetrazolyl, pyrazolyl, 1, 2, 4-triazolyl, 1, 2, 3-triazolyl, thiadiazolyl, oxadiazolyl, pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, indolyl, isoindolyl, indolizinyl, benzofuranyl, or isobenzofuranyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-
  • R D is C 6 -C 10 aryl-C 1 -C 6 alkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 haloalkyl, –SF 5 , –OR a , –OC (O) NR c R d , –NR c R d , –NR c C (O) R b , –S (O) NR c R d , –S (O) 2 R b , –NR c S (O) 2 R b , –S (O) 2 NR c R d ,
  • R D is benzyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 haloalkyl, –SF 5 , –OR a , –OC (O) NR c R d , –NR c R d , –NR c C (O) R b , –S (O) NR c R d , –S (O) 2 R b , –NR c S (O) 2 R b , –S (O) 2 NR c R d , –NR c S (O) 2 NR c R d ,
  • R D is 5-10 membered heteroaryl-C 1 -C 6 alkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 haloalkyl, –SF 5 , –OR a , –OC (O) NR c R d , –NR c R d , –NR c C (O) R b , –S (O) NR c R d , –S (O) 2 R b , –NR c S (O) 2 R b , –S (O) 2 NR c R d ,
  • R D is –CH 2 -pyrrolyl, –CH 2 -imidazolyl, –CH 2 -oxazolyl, –CH 2 -isoxazolyl, –CH 2 -thiazolyl, –CH 2 -tetrazolyl, –CH 2 -pyrazolyl, –CH 2 -1, 2, 4-triazolyl, –CH 2 -1, 2, 3-triazolyl, –CH 2 -thiadiazolyl, –CH 2 -oxadiazolyl, –CH 2 -pyridinyl, –CH 2 -pyrimidinyl, –CH 2 -pyrazinyl, –CH 2 -pyridazinyl, –CH 2 -indolyl, or –CH 2 -isoindolyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –CN, halo, ox
  • R D is C 3 -C 10 cycloalkyl-C 1 -C 6 alkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 haloalkyl, –SF 5 , –OR a , –OC (O) NR c R d , –NR c R d , –NR c C (O) R b , –S (O) NR c R d , –S (O) 2 R b , –NR c S (O) 2 R b , –S (O) 2 NR c R
  • R D is –CH 2 -cyclopropyl, –CH 2 -cyclobutyl, –CH 2 -cyclopentyl, or –CH 2 -cyclohexyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 haloalkyl, –SF 5 , –OR a , –OC (O) NR c R d , –NR c R d , –NR c C (O) R b , –S (O) NR c R d , –S (O) 2 R b
  • R D is 4-10 membered heterocycloalkyl-C 1 -C 6 alkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 haloalkyl, –SF 5 , –OR a , –OC (O) NR c R d , –NR c R d , –NR c C (O) R b , –S (O) NR c R d , –S (O) 2 R b , –NR c S (O) 2 R b , –S (O) 2 NR c R d
  • R D is –CH 2 -azetidinyl, –CH 2 -oxetanyl, –CH 2 -pyrrolidinyl, –CH 2 -tetrahydrofuranyl, –CH 2 -piperidinyl, –CH 2 -dioxanyl, –CH 2 -tetrahydropyranyl, –CH 2 -piperazinyl, –CH 2 -morpholinyl, –CH 2 -azepanyl, –CH 2 -diazocanyl, –CH 2 -1, 4-diazepanyl, or –CH 2 -azepanyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, C 1 —CN,
  • R D is (i) H; or (ii) C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6 -C 10 aryl, 5-10 membered heteroaryl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 haloalkyl, –SF 5 ,
  • R D is (i) H; or (ii) C 1 -C 6 alkyl, C 3 -C 10 cycloalkyl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, cycloalkylalkyl, or heteroarylalkyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently cyano, halo, C 1 -C 4 alkyl, –OR a , or –NR c R d ; wherein each R a , R c , and R d is as defined herein.
  • R D is (i) H; or (ii) methyl, ethyl, propyl, cyclopropyl, cyclohexyl, tetrahydropyranyl, pyrazolyl, cyclopropylmethyl, or pyridinyl-methyl, each optionally substituted with 1, 2, or 3, substituents, each of which is independently cyano, fluoro, methyl, hydroxyl, methoxy, or dimethylamino.
  • R D is H, methyl, ethyl, 2-cyanoethyl, 2, 2, 2-trifluoroethyl, 2-hydroxyethyl, 2-methoxyethyl, 2-dimethylaminoethyl, isopropyl, 2-hydroxypropyl, 2-hydroxy-2-methylpropyl, 2-methoxy-2-methylpropyl, cyclopropyl, 4-hydroxy-cyclohexyl, tetrahydropyran-4-yl, 1-methylpyrazol-4-yl, (1-hydroxycyclopropyl) methyl, (1-methoxycyclopropyl) methyl, or pyridin-2-ylmethyl.
  • R 3 is –CF 2 CH 2 CONHCH 3 , –CF 2 CH 2 CON (CH 3 ) 2 ,
  • R 3 is straight-chained or branched C 1 -C 8 alkyl, each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 substituents, each of which is independently R 4 ; with the proviso that one of R 4 is –C (O) OR A ; wherein R 4 and R A are each as defined herein.
  • R 3 is straight-chained or branched C 1 -C 3 alkyl, each optionally substituted with 1, 2, 3, 4, 5, or 6 substituents, each of which is independently R 4 ; with the proviso that one of R 4 is –C (O) OR A ; wherein R 4 and R A are each as defined herein.
  • R 3 is wherein each R 4 and R A is as defined herein.
  • R 3 is
  • R 3 is straight-chained or branched C 1 -C 8 alkyl or C 1 -C 3 alkyl, each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 substituents, each of which is independently R 4 ; with the proviso that one of R 4 is –C (O) NR C S (O) R B ; wherein R 4 , R B , and R C are each as defined herein.
  • R 3 is wherein each R 4 , R B , and R C is as defined herein.
  • R 3 is straight-chained or branched C 1 -C 8 alkyl or C 1 -C 3 alkyl, each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 substituents, each of which is independently R 4 ; with the proviso that one of R 4 is –C (O) NR C S (O 2 ) R B ; wherein R 4 , R B , and R C are each as defined herein.
  • R 3 is wherein each R 4 , R B , and R C is as defined herein.
  • R 3 is
  • R 3 is straight-chained or branched C 1 -C 8 alkyl or C 1 -C 3 alkyl, each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 substituents, each of which is independently R 4 ; with the proviso that one of R 4 is –OC (O) R B ; wherein R 4 and R B are each as defined herein. In certain embodiments, R 3 is wherein each R 4 and R B is as defined herein.
  • R 3 is straight-chained or branched C 1 -C 8 alkyl or C 1 -C 3 alkyl, each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 substituents, each of which is independently R 4 ; with the proviso that one of R 4 is –OC (O) NR C R D ; wherein R 4 , R C , and R D are each as defined herein. In certain embodiments, R 3 is wherein each R 4 , R C , and R D is as defined herein.
  • R 3 is straight-chained or branched C 1 -C 8 alkyl or C 1 -C 3 alkyl, each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 substituents, each of which is independently R 4 ; with the proviso that one of R 4 is –NR C R D ; wherein R 4 , R C , and R D are each as defined herein. In certain embodiments, R 3 is wherein each R 4 , R C , and R D is as defined herein.
  • R 3 is, –CF 2 CH 2 NH 2 , –CF 2 CH 2 NHCH 3 , –CF 2 CH 2 N (CH 3 ) 2 , –CF 2 CH 2 NHCH 2 CH 3 , –CF 2 CH 2 N (CH 2 CH 3 ) 2 , –CF 2 CH 2 CH 2 NH 2 , –CF 2 CH 2 CH 2 NHCH 3 , –CF 2 CH 2 CH 2 N (CH 3 ) 2 , –CF 2 CH 2 CH 2 NHCH 2 CH 3 , or –CF 2 CH 2 CH 2 N (CH 2 CH 3 ) 2 .
  • R 3 is straight-chained or branched C 1 -C 8 alkyl or C 1 -C 3 alkyl, each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 substituents, each of which is independently R 4 ; with the proviso that one of R 4 is –NR C C (O) R B ; wherein R 4 , R B , and R C are each as defined herein. In certain embodiments, R 3 is wherein each R 4 , R B , and R C is as defined herein.
  • R 3 is straight-chained or branched C 1 -C 8 alkyl or C 1 -C 3 alkyl, each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 substituents, each of which is independently R 4 ; with the proviso that one of R 4 is –NR C C (O) NR C R D ; wherein each R 4 , R C , and R D is as defined herein. In certain embodiments, R 3 is wherein each R 4 , R C , and R D is as defined herein.
  • R 3 is straight-chained or branched C 1 -C 8 alkyl or C 1 -C 3 alkyl, each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 substituents, each of which is independently R 4 ; with the proviso that one of R 4 is –NR C C (O) OR A ; wherein R 4 , R A , and R C are each as defined herein. In certain embodiments, R 3 is wherein each R 4 , R A , and R C is as defined herein.
  • R 3 is straight-chained or branched C 1 -C 8 alkyl or C 1 -C 3 alkyl, each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 substituents, each of which is independently R 4 ; with the proviso that one of R 4 is –SR A ; wherein R 4 and R A are each as defined herein. In certain embodiments, R 3 is wherein each R 4 and R A is as defined herein.
  • R 3 is straight-chained or branched C 1 -C 8 alkyl or C 1 -C 3 alkyl, each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 substituents, each of which is independently R 4 ; with the proviso that one of R 4 is –S (O) R B ; wherein R 4 and R B are each as defined herein. In certain embodiments, R 3 is wherein each R 4 and R B is as defined herein.
  • R 3 is straight-chained or branched C 1 -C 8 alkyl or C 1 -C 3 alkyl, each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 substituents, each of which is independently R 4 ; with the proviso that one of R 4 is –S (O) 2 R B ; wherein R 4 and R B are each as defined herein. In certain embodiments, R 3 is wherein each R 4 and R B is as defined herein.
  • R 3 is straight-chained or branched C 1 -C 8 alkyl or C 1 -C 3 alkyl, each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 substituents, each of which is independently R 4 ; with the proviso that one of R 4 is –S (O) NR C R D ; wherein R 4 , R C , and R D are each as defined herein. In certain embodiments, R 3 is wherein each R 4 , R C , and R D is as defined herein.
  • R 3 is straight-chained or branched C 1 -C 8 alkyl or C 1 -C 3 alkyl, each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 substituents, each of which is independently R 4 ; with the proviso that one of R 4 is –NR C S (O) 2 R D ; wherein R 4 , R C , and R D are each as defined herein. In certain embodiments, R 3 is wherein each R 4 , R C , and R D is as defined herein.
  • R 3 is straight-chained or branched C 1 -C 8 alkyl or C 1 -C 3 alkyl, each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 substituents, each of which is independently R 4 ; with the proviso that one of R 4 is –S (O) 2 NR C R D ; wherein R 4 , R C , and R D are each as defined herein.
  • R 3 is wherein each R 4 , R C , and R D is as defined herein.
  • R 3 is straight-chained or branched C 1 -C 8 alkyl or C 1 -C 3 alkyl, each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 substituents, each of which is independently R 4 ; with the proviso that one of R 4 is –NR C S (O) 2 NR C R D ; wherein each R 4 , R C , and R D is as defined herein. In certain embodiments, R 3 is wherein each R 4 , R C , and R D is as defined herein.
  • R 3 is C 2 -C 8 alkenyl optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 substituents, each of which is independently R 4 ; wherein R 4 is as defined herein.
  • R 3 is C 2 -C 8 alkynyl optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 substituents, each of which is independently R 4 ; wherein R 4 is as defined herein.
  • R 3 is C 6 -C 10 aryl, C 3 -C 10 cycloalkyl, 5-10 membered heteroaryl, or 4-10 membered heterocycloalkyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 13 ; wherein R 13 is as defined herein.
  • R 3 is C 6 -C 10 aryl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 13 ; wherein R 13 is as defined herein.
  • R 3 is phenyl or naphthyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 13 ; wherein R 13 is as defined herein.
  • R 3 is phenyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 13 ; wherein R 13 is as defined herein.
  • R 3 is C 3 -C 10 cycloalkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 13 ; wherein R 13 is as defined herein.
  • R 3 is cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 13 ; wherein R 13 is as defined herein.
  • R 3 is 5-10 membered heteroaryl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 13 ; wherein R 13 is as defined herein.
  • R 3 is pyrrolyl, furanyl, thiophenyl, imidazolyl, oxazolyl, thiazolyl, tetrazolyl, pyrazolyl, triazolyl, thiadiazolyl, oxadiazolyl, pyridinyl, pyrimidinyl, pyrazinyl, or pyridazinyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 13 ; wherein R 13 is as defined herein.
  • R 3 is 4-10 membered heterocycloalkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 13 ; wherein R 13 is as defined herein.
  • R 3 is azetidinyl, oxetanyl, thietanyl, pyrrolidinyl, tetrahydrofuranyl, tetrahydrothiophenyl, piperidinyl, tetrahydropyranyl, tetrahydrothiopyranyl, piperazinyl, morpholinyl, 1, 4-diazocanyl, 1, 4-diazepanyl, azepanyl, or 2, 6-diazaspiro [3.3] heptanyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R 13 ; wherein R 13 is as defined herein.
  • R 13 is H. In certain embodiments, R 13 is D. In certain embodiments, R 13 is halo. In certain embodiments, R 13 is –F, –Cl, –Br, or –I. In certain embodiments, R 13 is –SF 5 . In certain embodiments, R 13 is –CN. In certain embodiments, R 13 is –NO 2 . In certain embodiments, R 13 is oxo.
  • R 13 is C 1 -C 6 alkyl. In certain embodiments, R 13 is –CH 3 , –CH 2 CH 3 , –CH 2 CH 2 CH 3 , —CH (CH 3 ) 2 , –CH 2 CH 2 CH 2 CH 3 , –CH 2 CH (CH 3 ) 2 , or –C (CH 3 ) 3 . In certain embodiments, R 13 is C 2 -C 6 alkenyl. In certain embodiments, R 13 is C 2 -C 6 alkynyl. In certain embodiments, R 13 is C 1 -C 6 haloalkyl.
  • R 13 is –CH 2 F, –CHF 2 , –CF 3 , –CH 2 CH 2 F, –CH 2 CHF 2 , –CH 2 CF 3 , –CF 2 CH 3 , or –CF 2 CH 2 CH 3 .
  • R 13 is C 1 -C 6 cyanoalkyl.
  • R 13 is –CH 2 CN, –CH 2 CH 2 CN, or –CH 2 CH 2 CH 2 CN.
  • R 13 is –SR A , wherein R A is as defined herein. In certain embodiments, R 13 is –OR A , wherein R A is as defined herein. In certain embodiments, R 13 is –OCH 3 , –OCH 2 CH 3 , –OCH 2 CH 2 CH 3 , –OCH (CH 3 ) 2 , –OCH 2 F, –OCHF 2 , –OCF 3 , –OCH 2 CH 2 F, –OCH 2 CHF 2 , or –OCH 2 CF 3 .
  • R 13 is –C (O) R B , wherein R B is as defined herein. In certain embodiments, R 13 is –C (O) NR C R D , wherein R C and R D are each as defined herein. In certain embodiments, R 13 is –C (O) OR A , wherein R A is as defined herein. In certain embodiments, R 13 is –OC (O) R B , wherein R B is as defined herein. In certain embodiments, R 13 is –OC (O) NR C R D , wherein R C and R D are each as defined herein.
  • R 13 is –NR C R D , wherein R C and R D are each as defined herein.
  • R 13 is –NR C C (O) R B , wherein R B and R C are each as defined herein.
  • R 13 is –NR C C (O) NR C R D , wherein each R C and R D is as defined herein.
  • R 13 is –NR C C (O) OR A , wherein R A and R C are each as defined herein.
  • R 13 is –SiR G R H R I , wherein R G , R H , and R I are each as defined herein.
  • R 13 is –B (OR E ) (OR F ) , wherein R E and R F are each as defined herein.
  • R 13 is –S (O) R B , wherein R B is as defined herein.
  • R 13 is –S (O) NR C R D , wherein R C and R D are each as defined herein.
  • XVa a compound of Formula (XVa) , (XVb) , (XVc) , (XVd) , or (XVe) :
  • each Y 3 , R 1 , R 2 , and R 3 is as defined herein.
  • each Y 3 , R 1 , R 2 , and R 3 is as defined herein.
  • XVIIa a compound of Formula (XVIIa) , (XVIIb) , (XVIIc) , (XVIId) , or (XVIIe) :
  • each Y 3 , R 1 , R 2 , and R 3 is as defined herein.
  • R A is H or D.
  • R A is C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6 -C 10 aryl, 5-10 membered heteroaryl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which independently selected from D, –OH, –CN, halo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 alkyl-OH, C 1 -C 4 alkyl-CN, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1
  • R B is H or D.
  • R B is C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6 -C 10 aryl, 5-10 membered heteroaryl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently R B1 ; wherein each R B1 is independently D, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, C 1 -C 4 alkyl-O-C 1 -C 4 alkyl, C 1 -C 4 alkyl-O-C 1 -C 1 -
  • R C and R D are each independently H, D, or –CN.
  • R C and R D are each independently C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 7 cycloalkyl, 4-7 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl, each optionally substituted with 1, 2, 3, 4 or 5 substituents, each of which is independently D, –OH, –CN, halo, oxo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, –OC 1 -C 4 alkyl, –OC 1 -C 4 haloalkyl, C 1 -C 4 alkyl-
  • R C and R D together with the N atom to which they are attached form a 4-7 membered heterocycloalkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –OH, oxo, –CN, –NH 2 , –NH (C 1 -C 4 alkyl) , –N (C 1 -C 4 alkyl) 2 , halo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, –OC 1 -C 4 alkyl, or –OC 1 -C 4 haloalkyl.
  • R a is H or D.
  • R a is C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, phenyl, C 3 -C 7 cycloalkyl, 5-6 membered heteroaryl, or 4-7 membered heterocycloalkyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, halo, –OH, –CN, –NH 2 , –NH (C 1 -C 4 alkyl) , –N (C 1 -C 4 alkyl) 2 , C 1 -C 4 alkyl, –OC 1 -C 4 alkyl, C 1 -C 4 haloalkyl, or –OC 1 -C 4 haloalkyl.
  • R a1 is H or D.
  • R a1 is C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, phenyl, C 3 -C 7 cycloalkyl, 5-6 membered heteroaryl, or 4-7 membered heterocycloalkyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, halo, –OH, –CN, –NH 2 , –NH (C 1 -C 4 alkyl) , –N (C 1 -C 4 alkyl) 2 , C 1 -C 4 alkyl, –OC 1 -C 4 alkyl, C 1 -C 4 haloalkyl, or –OC 1 -C 4 haloalkyl.
  • R b is H or D.
  • R b is C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, phenyl, C 3- C 7 cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –OH, –CN, –NH 2 , –NH (C 1 -C 4 alkyl) , –N (C 1 -C 4 alkyl) 2 , halo, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkyl, C 1 -C 4 haloalkoxy, C 6- C 10 aryl,
  • R b1 is H or D.
  • R b1 is C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, phenyl, C 3- C 7 cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is Independently D, –OH, –CN, –NH 2 , –NH (C 1 -C 4 alkyl) , –N (C 1 -C 4 alkyl) 2 , halo, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkyl, C 1 -C 4 haloalkoxy, C 6- C 10
  • R c and R d are each independently H or D.
  • R c and R d are each independently C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 6- C 10 aryl, 5-10 membered heteroaryl, C 3- C 10 cycloalkyl, 4-10 membered heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, heterocycloalkylalkyl, arylcycloalkyl, arylheterocycloalkyl, arylheteroaryl, biaryl, heteroarylcycloalkyl, heteroarylheterocycloalkyl, heteroarylaryl, or biheteroaryl, each optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –OH, –CN, –
  • R c and R d together with the N atom to which they are attached form 4-7 membered heterocycloalkyl optionally substituted with 1, 2, 3, 4, or 5 substituents, each of which is independently D, –OH, –CN, –NH 2 , –NH (C 1 -C 4 alkyl) , –N (C 1 -C 4 alkyl) 2 , halo, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkyl, C 1 -C 4 haloalkoxy, C 1 -C 4 hydroxyalkyl, C 1 -C 4 cyanoalkyl, C 6 -C 10 aryl, 5-10 membered heteroaryl, C 1 -C 4 alkoxy-C 1 -C 4 alkyl, or C 1 -C 4 alkoxy-C 1 -C 4 alkoxy.
  • R E is H or D.
  • R E is C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 2 -C 4 alkenyl, (C 1 -C 4 alkoxy) -C 1 -C 4 alkyl, C 2 -C 4 alkynyl, C 6 -C 10 aryl, 5-10 membered heteroaryl, C 3 -C 10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6 -C 10 aryl-C 1 -C 4 alkyl, C 3 -C 10 cycloalkyl-C 1 -C 4 alkyl, 5-10 membered heteroaryl-C 1 -C 4 alkyl, or 4-10 membered heterocycloalkyl-C 1 -C 4 alkyl.
  • R F is H or D. In certain embodiments, R F is C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 6 -C 10 aryl, 5-10 membered heteroaryl, C 3 -C 10 cycloalkyl, or 4-10 membered heterocycloalkyl.
  • R e is C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 2 -C 4 alkenyl, (C 1 -C 4 alkoxy) -C 1 -C 4 alkyl, C 2 -C 4 alkynyl, C 6 -C 10 aryl, 5-10 membered heteroaryl, C 3 -C 10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6 -C 10 aryl-C 1 -C 4 alkyl, C 3 -C 10 cycloalkyl-C 1 -C 4 alkyl, 5-10 membered heteroaryl-C 1 -C 4 alkyl, or 4-10 membered heterocycloalkyl-C 1 -C 4 alkyl.
  • R f is H or D. In certain embodiments, R f is C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 6 -C 10 aryl, 5-10 membered heteroaryl, C 3 -C 10 cycloalkyl, or 4-10 membered heterocycloalkyl.
  • R G , R H and R I are each independently C 1 -C 4 alkyl or phenyl. In certain embodiments, R G is C 1 -C 4 alkyl or phenyl. In certain embodiments, R G is C 1 alkyl, C 2 alkyl, C 3 alkyl, or C 4 alkyl. In certain embodiments, R G is methyl, ethyl, propyl, butyl, or phenyl. In certain embodiments, R G is methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, t-butyl, or phenyl.
  • R H is C 1 -C 4 alkyl or phenyl. In certain embodiments, R H is C 1 alkyl, C 2 alkyl, C 3 alkyl, or C 4 alkyl. In certain embodiments, R H is methyl, ethyl, propyl, butyl, or phenyl. In certain embodiments, R H is methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, t-butyl, or phenyl. In certain embodiments, R I is C 1 -C 4 alkyl or phenyl.
  • R I is C 1 alkyl, C 2 alkyl, C 3 alkyl, or C 4 alkyl. In certain embodiments, R I is methyl, ethyl, propyl, butyl, or phenyl. In certain embodiments, R I is methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, t-butyl, or phenyl.
  • R g , R h and R i are each independently C 1 -C 4 alkyl or phenyl. In certain embodiments, R g is C 1 -C 4 alkyl or phenyl. In certain embodiments, R g is C 1 alkyl, C 2 alkyl, C 3 alkyl, or C 4 alkyl. In certain embodiments, R g is methyl, ethyl, propyl, butyl, or phenyl. In certain embodiments, R g is methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, t-butyl, or phenyl.
  • R h is C 1 -C 4 alkyl or phenyl. In certain embodiments, R h is C 1 alkyl, C 2 alkyl, C 3 alkyl, or C 4 alkyl. In certain embodiments, R h is methyl, ethyl, propyl, butyl, or phenyl. In certain embodiments, R h is methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, t-butyl, or phenyl. In certain embodiments, R i is C 1 -C 4 alkyl or phenyl.
  • R i is C 1 alkyl, C 2 alkyl, C 3 alkyl, or C 4 alkyl. In certain embodiments, R i is methyl, ethyl, propyl, butyl, or phenyl. In certain embodiments, R i is methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, t-butyl, or phenyl.
  • provided herein is a compound of:
  • the compounds provided herein can be asymmetric (e.g., having one or more stereocenters) . All stereoisomers, such as enantiomers and diastereomers, are contemplated unless otherwise indicated.
  • Cis and trans geometric isomers of the compounds provided herein are described and may be isolated as a mixture of isomers or as separated isomeric forms. Furthermore, atropisomers and mixtures thereof such as those resulting from restricted rotation about two aromatic or heteroaromatic rings bonded to one another are encompassed within the scope of the disclosure.
  • the compounds provided herein also include tautomeric forms.
  • Prototropic tautomeric forms result from the swapping of a single bond with an adjacent double bond together with the concomitant migration of a proton.
  • Tautomeric forms include prototropic tautomers which are isomeric protonation states having the same empirical formula and total charge.
  • prototropic tautomers examples include ketone–enol pairs, amide-imidic acid pairs, lactam-lactim pairs, amide-imidic acid pairs, enamine-imine pairs, and annular forms where a proton can occupy two or more positions of a heterocyclic system, for example, 1H-and 3H-imidazole, 1H-, 2H-, and 4H-1, 2, 4-triazole, 1H-and 2H-isoindole, and 1H-and 2H-pyrazole; certain hydroxy substituted compounds may exist as tautomers as shown below: etc. Tautomeric forms can be in equilibrium or sterically locked into one form by appropriate substitution.
  • the compounds of the present disclosure may exist as rotational isomers. Descriptions of a compound of the disclosure that do not indicate a particular rotational isomer are intended to encompass any individual rotational isomers, as well as mixtures of rotational isomers in any proportion. Depiction of a particular rotational isomer is meant to refer to the depicted rotational isomer, substantially free of other rotational isomers.
  • Compounds of the disclosure can also include all isotopes of atoms occurring in the intermediates or final compounds.
  • Isotopes include those atoms having the same atomic number but different mass numbers.
  • isotopes of hydrogen include tritium and deuterium.
  • the present disclosure also includes pharmaceutically acceptable salts of the compounds provided herein.
  • pharmaceutically acceptable salts include, but are not limited to, mineral or organic acid salts of basic residues such as amines; alkali or organic salts of acidic residues such as carboxylic acids.
  • the pharmaceutically acceptable salts of the present disclosure include the conventional non-toxic salts of the parent compound formed, for example, from non-toxic inorganic or organic acids. Lists of suitable salts are found in Remington’s Pharmaceutical Sciences, 17 th ed., Mack Publishing Company, Easton, Pa., 1985, p. 1418 and J. Pharm. Sci. 1977, 66, 2, each of which is incorporated herein by reference in its entirety.
  • a pharmaceutical composition comprising a compound provided herein, e.g., a compound of Formula (I) , or a pharmaceutically acceptable salt, solvate, N-oxide, tautomer, stereoisomer, atropisomer, isotopic variant, prodrug, or deuterated compound thereof; and a pharmaceutically acceptable excipient.
  • compositions can be formulated in a form suitable for oral administration (for example, as tablets, lozenges, hard or soft capsules, aqueous or oil suspensions, emulsions, dispersible powders or granules, syrups, or elixirs) , for injection (for example, as aqueous or oil suspensions, emulsions, elixirs, or a sterile aqueous solution) , for topical application (for example, as creams, ointments, gels, or aqueous or oil solutions or suspensions) , for inhalation (for example, as a finely divided powder or a liquid aerosol) , for insufflation (for example, as a finely divided powder) , or for parenteral administration (for example, as a sterile aqueous or oil solution for intravenous, subcutaneous, intramuscular, intraperitoneal, or intramuscular dosing, or as a suppository for rectal dos
  • the pharmaceutically acceptable excipient (s) can be, for example, carriers (e.g., a solid, liquid, or semi-solid carrier) , adjuvants, diluents, fillers or bulking agents, granulating agents, coating agents, release-controlling agents, binding agents, disintegrants, lubricating agents, preservatives, antioxidants, buffering agents, suspending agents, thickening agents, flavoring agents, sweeteners, taste masking agents, or stabilizers.
  • carriers e.g., a solid, liquid, or semi-solid carrier
  • adjuvants e.g., a solid, liquid, or semi-solid carrier
  • granulating agents e.g., granulating agents, coating agents, release-controlling agents, binding agents, disintegrants, lubricating agents, preservatives, antioxidants, buffering agents, suspending agents, thickening agents, flavoring agents, sweeteners, taste masking agents, or stabilizers.
  • the pharmaceutical carrier employed can be, for example, a solid, liquid, or gas.
  • solid carriers include lactose, terra alba, sucrose, talc, gelatin, agar, pectin, acacia, magnesium stearate, and stearic acid.
  • liquid carriers include sugar syrup, peanut oil, olive oil, and water.
  • gaseous carriers include carbon dioxide and nitrogen.
  • water, glycols, oils, alcohols, flavoring agents, preservatives, and coloring agents may be used to form oral liquid preparations such as suspensions, elixirs and solutions; while carriers such as starches, sugars, microcrystalline cellulose, diluents, granulating agents, lubricants, binders, and disintegrating agents may be used to form oral solid preparations, such as powders, capsules, and tablets.
  • Pharmaceutical dosage forms suitable for oral administration include tablets (coated or uncoated) , capsules (hard or soft shell) , caplets, pills, lozenges, syrups, solutions, powders, granules, elixirs, suspensions, sublingual tablets, wafers, or patches such as buccal patches.
  • tablet compositions can contain a unit dosage of an active compound together with an inert diluent or carrier such as a sugar or sugar alcohol, e.g., lactose, sucrose, sorbitol or mannitol; and/or a non-sugar derived diluent such as sodium carbonate, calcium phosphate, calcium carbonate, or a cellulose or derivative thereof, such as microcrystalline cellulose (MCC) , methyl cellulose, ethyl cellulose, and hydroxypropyl methyl cellulose, and starches such as corn starch.
  • an inert diluent or carrier such as a sugar or sugar alcohol, e.g., lactose, sucrose, sorbitol or mannitol
  • a non-sugar derived diluent such as sodium carbonate, calcium phosphate, calcium carbonate, or a cellulose or derivative thereof, such as microcrystalline cellulose (MCC) , methyl cellulose, eth
  • Tablets may also contain such standard ingredients as binding and granulating agents such as polyvinylpyrrolidone, disintegrants (e.g., swellable crosslinked polymers such as crosslinked carboxymethylcellulose) , lubricating agents (e.g., stearates) , preservatives (e.g., parabens) , antioxidants (e.g., BHT) , buffering agents (for example phosphate or citrate buffers) , and effervescent agents such as citrate/bicarbonate mixtures.
  • binding and granulating agents such as polyvinylpyrrolidone, disintegrants (e.g., swellable crosslinked polymers such as crosslinked carboxymethylcellulose) , lubricating agents (e.g., stearates) , preservatives (e.g., parabens) , antioxidants (e.g., BHT) , buffering agents (for example phosphate or citrate buffers)
  • compositions of the present disclosure suitable for parenteral administration may be prepared as solutions or suspensions of the active compounds in water.
  • a suitable surfactant can be included such as, for example, hydroxypropyl cellulose.
  • Dispersions can also be prepared in glycerol, liquid polyethylene glycols, and mixtures thereof in oils. Further, a preservative can be included to prevent the detrimental growth of microorganisms.
  • compositions of the present disclosure suitable for injectable use include sterile aqueous solutions or dispersions.
  • the compositions can be in the form of sterile powders for the extemporaneous preparation of such sterile injectable solutions or dispersions.
  • the final injectable form must be sterile and must be effectively fluid for easy syringability.
  • the pharmaceutical compositions must be stable under the conditions of manufacture and storage; thus, should be preserved against the contaminating action of microorganisms such as bacteria and fungi.
  • the carrier can be a solvent or dispersion medium containing, for example, water, ethanol, polyol (e.g., glycerol, propylene glycol and liquid polyethylene glycol) , vegetable oils, and suitable mixtures thereof.
  • compositions of the present disclosure can be in a form suitable for topical use such as, for example, an aerosol, cream, ointment, lotion, or dusting powder. Further, the compositions can be in a form suitable for use in transdermal devices.
  • the pharmaceutical formulations described herein may include, as appropriate, one or more additional carrier ingredients such as diluents, buffers, flavoring agents, binders, surface-active agents, thickeners, lubricants, and preservatives (including antioxidants) .
  • additional carrier ingredients such as diluents, buffers, flavoring agents, binders, surface-active agents, thickeners, lubricants, and preservatives (including antioxidants) .
  • additional carrier ingredients such as diluents, buffers, flavoring agents, binders, surface-active agents, thickeners, lubricants, and preservatives (including antioxidants) .
  • additional carrier ingredients such as diluents, buffers, flavoring agents, binders, surface-active agents, thickeners, lubricants, and preservatives (including antioxidants) .
  • preservatives including antioxidants
  • provided herein is a method for treating or preventing cancer in a subject, comprising administering to the subject in need thereof a therapeutically effective amount of a compound provided herein, e.g., a compound of Formula (I) , or a pharmaceutically acceptable salt, solvate, N-oxide, tautomer, stereoisomer, atropisomer, isotopic variant, prodrug, or deuterated compound thereof; or a pharmaceutical composition provided herein.
  • a compound provided herein e.g., a compound of Formula (I) , or a pharmaceutically acceptable salt, solvate, N-oxide, tautomer, stereoisomer, atropisomer, isotopic variant, prodrug, or deuterated compound thereof; or a pharmaceutical composition provided herein.
  • the cancer is characterized by PolQ overexpression. In certain embodiments, the cancer is the characterized by increased dependence on MMEJ DSB repair. In certain embodiments, the cancer is characterized by HR-deficiency. In certain embodiments, the cancer is characterized by a reduction or absence of expression of a HR-associated gene. In certain embodiments, the cancer lacks a 53BP1/Shieldin complex. In certain embodiments, the cancer is resistant to PARPi treatment. In certain embodiments, the cancer is characterized by NHEJ deficiency. In certain embodiments, the cancer is a reduction or absence of expression of an NHEJ-associated gene.
  • a method for treating or preventing a disease characterized by PolQ overexpression in a subject comprising administering to the subject in need thereof a therapeutically effective amount of a compound provided herein, e.g., a compound of Formula (I) , or a pharmaceutically acceptable salt, solvate, N-oxide, tautomer, stereoisomer, atropisomer, isotopic variant, prodrug, or deuterated compound thereof; or a pharmaceutical composition provided herein.
  • a compound provided herein e.g., a compound of Formula (I) , or a pharmaceutically acceptable salt, solvate, N-oxide, tautomer, stereoisomer, atropisomer, isotopic variant, prodrug, or deuterated compound thereof; or a pharmaceutical composition provided herein.
  • PolQ overexpression refers to the increased expression or activity of a PolQ enzyme in a diseased cell, e.g., cancer cell, relative to the expression or activity of a PolQ enzyme in a control cell (e.g., non-diseased cell of the same type) .
  • the PolQ overexpression is at least 2-fold, at least 3-fold, at least 4-fold, at least 6-fold, at least 10-fold, at least 20-fold, or at least 50-fold relative to the PolQ expression in a control cell.
  • PolQ overexpressing cancer include, but are not limited to, certain ovarian, breast, cervical, uterine, pancreatic, lung, colorectal, gastric, bladder, and prostate cancer.
  • a method for treating or preventing a disease characterized by increased dependence upon MMEJ DSB repair in a subject comprising administering to the subject in need thereof a therapeutically effective amount of a compound provided herein, e.g., a compound of Formula (I) , or a pharmaceutically acceptable salt, solvate, N-oxide, tautomer, stereoisomer, atropisomer, isotopic variant, prodrug, or deuterated compound thereof; or a pharmaceutical composition provided herein.
  • a compound provided herein e.g., a compound of Formula (I) , or a pharmaceutically acceptable salt, solvate, N-oxide, tautomer, stereoisomer, atropisomer, isotopic variant, prodrug, or deuterated compound thereof; or a pharmaceutical composition provided herein.
  • a method for treating or preventing a disease characterized by HR-deficiency, a reduction or absence of the expression of an HR-associated gene in a subject comprising administering to the subject in need thereof a therapeutically effective amount of a compound provided herein, e.g., a compound of Formula (I) , or a pharmaceutically acceptable salt, solvate, N-oxide, tautomer, stereoisomer, atropisomer, isotopic variant, prodrug, or deuterated compound thereof; or a pharmaceutical composition provided herein.
  • a compound provided herein e.g., a compound of Formula (I) , or a pharmaceutically acceptable salt, solvate, N-oxide, tautomer, stereoisomer, atropisomer, isotopic variant, prodrug, or deuterated compound thereof; or a pharmaceutical composition provided herein.
  • the HR-associated gene is ATM, ATR, BARD1, BLM, BRCA1, BRCA2, BRIP1, CDK12, CHEK1, CHEK2, CtIP (BCL11A) , ERCC4 (FANCQ) , FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANJ (BRIP1) , FANCL, FANCM, FANCN (PALB2) , FANCP (SLX4) , LIG1, MRE11, NBS1, NBN, PTEN, RAD50, RAD51B, RAD51C, RAD54, RECQL4, RPA1, RPA2, SMARCA2, SMARCA4, WRN, or XRCC2.
  • a method for treating or preventing a disease lacking a 53BP1/Shieldin complex in a subject comprising administering to the subject in need thereof a therapeutically effective amount of a compound provided herein, e.g., a compound of Formula (I) , or a pharmaceutically acceptable salt, solvate, N-oxide, tautomer, stereoisomer, atropisomer, isotopic variant, prodrug, or deuterated compound thereof; or a pharmaceutical composition provided herein.
  • a compound provided herein e.g., a compound of Formula (I) , or a pharmaceutically acceptable salt, solvate, N-oxide, tautomer, stereoisomer, atropisomer, isotopic variant, prodrug, or deuterated compound thereof; or a pharmaceutical composition provided herein.
  • a method for treating or preventing a disease resistant to PARPi treatment in a subject comprising administering to the subject in need thereof a therapeutically effective amount of a compound provided herein, e.g., a compound of Formula (I) , or a pharmaceutically acceptable salt, solvate, N-oxide, tautomer, stereoisomer, atropisomer, isotopic variant, prodrug, or deuterated compound thereof; or a pharmaceutical composition provided herein.
  • a compound provided herein e.g., a compound of Formula (I) , or a pharmaceutically acceptable salt, solvate, N-oxide, tautomer, stereoisomer, atropisomer, isotopic variant, prodrug, or deuterated compound thereof; or a pharmaceutical composition provided herein.
  • a method for treating or preventing a disease characterized by NHEJ deficiency, or a reduction or absence of expression of an NHEJ-associated gene in a subject comprising administering to the subject in need thereof a therapeutically effective amount of a compound provided herein, e.g., a compound of Formula (I) , or a pharmaceutically acceptable salt, solvate, N-oxide, tautomer, stereoisomer, atropisomer, isotopic variant, prodrug, or deuterated compound thereof; or a pharmaceutical composition provided herein.
  • a compound provided herein e.g., a compound of Formula (I) , or a pharmaceutically acceptable salt, solvate, N-oxide, tautomer, stereoisomer, atropisomer, isotopic variant, prodrug, or deuterated compound thereof; or a pharmaceutical composition provided herein.
  • the NHEJ-associated gene is 53BP1, DCLRE1C, LIG4, NHEJ1, POLL, POLM, PRKDC, RIF1, SHLD1, SHLD2, SHLD3, XRCC4, XRCC5, or XRCC6.
  • the subject is a mammal. In certain embodiments, the subject is a human.
  • the therapeutically effective amount of a compound provided herein is ranging from about 0.1 to about 100 mg/kg/day, from about 0.1 to about 50 mg/kg/day, from about 0.1 to about 25 mg/kg/day, from about 0.1 to about 20 mg/kg/day, from about 0.1 to about 15 mg/kg/day, from about 0.1 to about 10 mg/kg/day, or from about 0.1 to about 5 mg/kg/day.
  • the therapeutically effective amount of a compound provided herein is ranging from about 0.1 to about 100 mg/kg/day.
  • the therapeutically effective amount of a compound provided herein is ranging from about 0.1 to about 50 mg/kg/day.
  • the therapeutically effective amount of a compound provided herein is ranging from about 0.1 to about 25 mg/kg/day. In yet another embodiment, the therapeutically effective amount of a compound provided herein is ranging from about 0.1 to about 20 mg/kg/day. In yet another embodiment, the therapeutically effective amount of a compound provided herein is ranging from about 0.1 to about 15 mg/kg/day. In yet another embodiment, the therapeutically effective amount of a compound provided herein is ranging from about 0.1 to about 10 mg/kg/day. In still another embodiment, the therapeutically effective amount of a compound provided herein is ranging from about 0.1 to about 5 mg/kg/day.
  • the administered dose can also be expressed in units other than mg/kg/day.
  • doses for parenteral administration can be expressed as mg/m 2 /day.
  • doses for parenteral administration can be expressed as mg/m 2 /day.
  • One of ordinary skill in the art would readily know how to convert doses from mg/kg/day to mg/m 2 /day to given either the height or weight of a subject or both. For example, a dose of 1 mg/m 2 /day for a 65 kg human is approximately equal to 58 mg/kg/day.
  • a compound provided herein may be administered by oral, parenteral (e.g., intramuscular, intraperitoneal, intravenous, CIV, intracisternal injection or infusion, subcutaneous injection, or implant) , inhalation, nasal, vaginal, rectal, sublingual, or topical (e.g., transdermal or local) routes of administration.
  • parenteral e.g., intramuscular, intraperitoneal, intravenous, CIV, intracisternal injection or infusion, subcutaneous injection, or implant
  • inhalation nasal, vaginal, rectal, sublingual, or topical (e.g., transdermal or local) routes of administration.
  • a compound provided herein may be formulated in suitable dosage unit with a pharmaceutically acceptable excipient, carrier, adjuvant, or vehicle, appropriate for each route of administration.
  • a compound provided herein is administered orally. In another embodiment, a compound provided herein is administered parenterally. In yet another embodiment, a compound provided herein is administered intravenously. In yet another embodiment, a compound provided herein is administered intramuscularly. In yet another embodiment, a compound provided herein is administered subcutaneously. In still another embodiment, a compound provided herein is administered topically.
  • a compound provided herein can be delivered as a single dose such as, e.g., a single bolus injection, or oral tablets or pills; or over time such as, e.g., continuous infusion over time or divided bolus doses over time.
  • a compound provided herein can be administered repetitively, if necessary, for example, until the subject experiences stable disease or regression, or until the subject experiences disease progression or unacceptable toxicity.
  • a compound provided herein can be administered once daily (QD) or divided into multiple daily doses such as twice daily (BID) , and three times daily (TID) .
  • the administration can be continuous, i.e., every day, or intermittently.
  • the term “intermittent” or “intermittently” as used herein is intended to mean stopping and starting at either regular or irregular intervals.
  • intermittent administration of a compound provided herein is administration for one to six days per week, administration in cycles (e.g., daily administration for two to eight consecutive weeks, then a rest period with no administration for up to one week) , or administration on alternate days.
  • a compound provided herein can also be combined or used in combination with other therapeutic agents useful in the treatment and/or prevention of a disease described herein.
  • the compounds provided herein, including salts thereof, can be prepared using known organic synthesis techniques and can be synthesized according to any of numerous possible synthetic routes, such as those exemplified herein.
  • the reactions for preparing compounds of the invention can be carried out in suitable solvents which can be readily selected by one of skill in the art of organic synthesis.
  • suitable solvents can be substantially non-reactive with the starting materials (reactants) , the intermediates or products at the temperatures at which the reactions are carried out, e.g., temperatures which can range from the solvent’s freezing temperature to the solvent’s boiling temperature.
  • a given reaction can be carried out in one solvent or a mixture of more than one solvent.
  • suitable solvents for a particular reaction step can be selected by the skilled artisan.
  • Preparation of compounds of the invention can involve the protection and deprotection of various chemical groups.
  • the need for protection and deprotection, and the selection of appropriate protecting groups, can be readily determined by one skilled in the art.
  • the chemistry of protecting groups is described, e.g., in Kocienski, Protecting Groups, (Thieme, 2007) ; Robertson, Protecting Group Chemistry, (Oxford University Press, 2000) ; Smith el ah, March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure, 8th Ed. (Wiley, 2019) ; Peturssion et al, "Protecting Groups in Carbohydrate Chemistry, " J Chem. Educ., 1997, 74 (11) , 1297; and Wuts et al., Protective Groups in Organic Synthesis, 5th Ed., (Wiley, 2014) .
  • Reactions can be monitored according to any suitable method known in the art.
  • product formation can be monitored by spectroscopic means, such as nuclear magnetic resonance spectroscopy (e.g., 1 H or 13 C) , infrared spectroscopy, spectrophotometry (e.g., UV-visible) , or mass spectrometry, or by chromatography such as high performance liquid chromatography (HPLC) or thin layer chromatography.
  • spectroscopic means such as nuclear magnetic resonance spectroscopy (e.g., 1 H or 13 C) , infrared spectroscopy, spectrophotometry (e.g., UV-visible) , or mass spectrometry
  • chromatography such as high performance liquid chromatography (HPLC) or thin layer chromatography.
  • ambient temperature e.g., a reaction temperature
  • room temperature e.g., a temperature from about 20 °C to about 30 °C.
  • heterocyclic amide derivatives of formula (I) can be prepared as the methods described in Scheme 1.
  • Heterocyclic amide derivatives (I) can be prepared by reactions of carboxylic acids 1-1 with suitable 1, 3, 4-thiadiazol-2-amine derivatives 1-2 under standard amide coupling conditions (e.g., in the presence of an activating reagent such as BOP, PyBOP, HATU, HBTU, EDCI, or T 3 P and a base, such as Hunig’s base, Et 3 N, pyridine or DMAP) .
  • an activating reagent such as BOP, PyBOP, HATU, HBTU, EDCI, or T 3 P
  • a base such as Hunig’s base, Et 3 N, pyridine or DMAP
  • a series of heterocyclic amide derivatives of formula (I) can be prepared as the methods described in Scheme 2.
  • Amide derivatives 2-3 can be prepared by reactions of carboxylic acids 2-1 with suitable 1, 3, 4-thiadiazol-2-amine derivatives 2-2 in a similar manner as those described in the Scheme 1.
  • a palladium catalyst such as Pd (OAc) 2 , Pd (dppf) Cl 2 , Pd 2 (dba) 3 , Pd (PPh 3
  • a palladium catalyst such as Pd (OAc) 2 , Pd (dppf) Cl 2 , Pd 2 (dba) 3 , Pd (PPh 3
  • a series of heterocyclic acid intermediates of formula 3-5 can be prepared as the methods described in Scheme 3.
  • C-C coupling of compounds 3-1 with 3-3 can provide ester compounds 3-4 by the methods Suzuki coupling or Stille coupling as described in Scheme 2. Saponification of the compounds 3-4 can yield the corresponding acid 3-5 under a base such as LiOH, NaOH, KOH or Me 3 SnOH.
  • Suzuki coupling of carboxylic acids 3-2 with compounds 3-3 can directly provide the corresponding acid 3-5 under standard Suzuki coupling conditions or Stille coupling conditions as described in Scheme 3.
  • a series of 1, 3, 4-thiadiazol-2-amine derivatives of formula 4-3 can be prepared as the methods described in Scheme 4.
  • Treatment of carboxylic acids 4-1 or cyanide 4-2 with thiosemicarbazide in the presence of a dehydrant such as POCl 3 , TFA, PCl 5 , P 2 O 5 or PPA can provide the 1, 3, 4-thiadiazol-2-amine derivatives 4-3.
  • a series of 1, 3, 4-thiadiazol-2-amine derivatives of formula 5-4 can be prepared as the methods described in Scheme 5.
  • Treatment of mono-ethyl difluoro-malonate 5-2 with thiosemicarbazide in the presence of a dehydrant such as POCl 3 , TFA, PCl 5 , P 2 O 5 or PPA can provide 1, 3, 4-thiadiazol-2-amine derivatives 5-4.
  • condensations of compound 5-5 or mono-ethyl malonic chloride 5-6 with thiosemicarbazide can yield 1, 3, 4-thiadiazol-2-amine derivatives 5-7 which can be transformed into the 1, 3, 4-thiadiazol-2-amine derivatives 5-4 by treatment with a fluorination reagent such as N-fluorobenzenesulfonimide (NFSI) , and N-fluoropyridinum salts (NFPY) .
  • a fluorination reagent such as N-fluorobenzenesulfonimide (NFSI) , and N-fluoropyridinum salts (NFPY) .
  • 1, 3, 4-thiadiazol-2-amine derivatives 5-4 can be directly prepared from reactions of aminothiadiazole 5-8 with 2-bromo-2, 2-difluoroacetic acid esters 5-9 and H 2 O 2 in the presence of a catalyst such as Cp 2 Fe.
  • Carboxic acids 6-2 can be prepared from C-C coupling of ethyl 2, 2-difluoro-2- (trimethylsilyl) acetate 6-1 with X-R AA where X is halo (e.g., Cl, Br, or I) or pseudohalogen (e.g., Otf or OMs) and R AA is C 0 -C 7 alkyl, C 2 -C 7 alkenyl, C 2 -C 7 alkynyl or R 4 (wherein the C 0 -C 7 alkyl, C 2 -C 7 alkenyl, or C 2 -C 7 alkynyl is optionally substituted with 1, 2, 3, 4, 5 or 6 substituents independently selected from R 4 ) in the presence of a suitable reagent such as KF or TBAF.
  • Saponification of the compounds 6-2 can yield the corresponding acids 6-3 under basic conditions in the presence of a bas such as LiOH, NaOH, KOH or Me 3 SnOH.
  • a bas such as LiOH, NaOH, KOH or Me 3 SnOH.
  • Cyclization of the acids 6-3 with thiosemicarbazide can provide the corresponding 5- (difluoromethyl) -1, 3, 4-thiadiazol-2-amine derivatives 6-6 under the conditions as described in Scheme 4.
  • 5- (difluoromethyl) -1, 3, 4-thiadiazol-2-amine derivatives 6-6 can be prepared from 5-amino-1, 3, 4-thiadiazol-2-one derivative 6-5 under an electrophilic fluorination reagent such as DAST, BAST, or XeF 2 .
  • the 5-amino-1, 3, 4-thiadiazol-2-one derivatives 6-5 can be prepared by reaction of Weinreb amide compound 6-4 with organometallic reagents such as R AA MgBr under the conditions of standard Weinreb ketone synthesis.
  • a series of 5- (difluoromethyl) -1, 3, 4-thiadiazol-2-amine derivatives of formula 7-4 can be prepared as the methods described in Scheme 7.
  • C-O coupling of ethyl 2-bromo-2, 2-difluoroacetate 7-1 with HO-R A2 in the presence of a base such as Na 2 CO 3 , K 2 CO 3 , NaH, or t-BuOK can compounds 7-2.
  • Saponification of the compounds 7-2 can yield the corresponding acids 7-3 in the presence of a base such as LiOH, NaOH, KOH or Me 3 SnOH.
  • Cyclization of the acids 7-3 with thiosemicarbazide can produce the corresponding 5- (difluoromethyl) -1, 3, 4-thiadiazol-2-amine derivatives 7-4 under the conditions as described in Scheme 4.
  • Example 1 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -6-methyl-N- (5- ( ( ( (S) -tetrahydrofuran-3-yl) oxy) methyl) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Step 1 (S) -2- ( (tetrahydrofuran-3-yl) oxy) acetic acid
  • Step 2 (S) -5- ( ( (tetrahydrofuran-3-yl) oxy) methyl) -1, 3, 4-thiadiazol-2-amine
  • Step 3 4- (3-chloro-2-fluoro-6-methoxyphenyl) -6-methyl-N- (5- ( ( ( (S) -tetrahydrofuran-3-yl) oxy) methyl) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Example 2 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -6-methyl-N- (5- ( ( ( (R) -tetrahydrofuran-3-yl) oxy) methyl) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Example 3 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -6-methyl-N- (5- ( ( (tetrahydro-2H-pyran-4-yl) oxy) methyl) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Step 1 5- ( ( (tetrahydro-2H-pyran-4-yl) oxy) methyl) -1, 3, 4-thiadiazol-2-amine
  • Step 2 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -6-methyl-N- (5- ( ( (tetrahydro-2H-pyran-4-yl) oxy) methyl) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Example 4 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -6-methyl-N- (5- ( ( (-4-oxoadamantan-1-yl) oxy) methyl) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Step 1 5- ( (5-amino-1, 3, 4-thiadiazol-2-yl) methoxy) adamantan-2-one
  • Step 2 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -6-methyl-N- (5- ( ( (-4-oxoadamantan-1-yl) oxy) methyl) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Example 5 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5- ( ( (-4-hydroxyadamantan-1-yl) oxy) methyl) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Example 6 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -6-methyl-N- (5- ( ( (tetrahydro-2H-pyran-3-yl) oxy) methyl) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Step 1 5- ( ( (tetrahydro-2H-pyran-3-yl) oxy) methyl) -1, 3, 4-thiadiazol-2-amine
  • Step 2 4- (3-chloro-2-fluoro-6-methoxyphenyl) -6-methyl-N- (5- ( ( (tetrahydro-2H-pyran-4-yl) oxy) methyl) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Example 7 4- (2-Fluoro-6-methoxyphenyl) -6-methyl-N- (5- ( ( (tetrahydro-2H-pyran-3-yl) oxy) methyl) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Example 8 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5- ( (cyclohex-3-en-1-yloxy) methyl) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Step 1 2- ( (4- ( (tert-butyldimethylsilyl) oxy) cyclohexyl) oxy) acetic acid
  • Step 2 5- ( (cyclohex-3-en-1-yloxy) methyl) -1, 3, 4-thiadiazol-2-amine
  • Step 3 4- (3-chloro-2-fluoro-6-methoxyphenyl) -N- (5- ( (cyclohex-3-en-1-yloxy) methyl) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Example 9 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -6-methyl-N- (5- ( ( ( (S) -1-tosylpyrrolidin-3-yl) oxy) methyl) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Step 1 (S) -5- ( ( (1-tosylpyrrolidin-3-yl) oxy) methyl) -1, 3, 4-thiadiazol-2-amine
  • Step 2 4- (3-chloro-2-fluoro-6-methoxyphenyl) -6-methyl-N- (5- ( ( ( (S) -1-tosylpyrrolidin-3-yl) oxy) methyl) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Example 10 4- (2-Fluoro-6-methoxyphenyl) -N- (5- (fluoromethyl) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Step 1 2- (5- (hydroxymethyl) -1, 3, 4-thiadiazol-2-yl) isoindoline-1, 3-dione
  • Step 2 2- (5- (fluoromethyl) -1, 3, 4-thiadiazol-2-yl) isoindoline-1, 3-dione
  • Step 4 4- (2-fluoro-6-methoxyphenyl) -N- (5- (fluoromethyl) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Example 11 4- (2-Fluoro-6-methoxyphenyl) -6-methyl-N- (5- (difluoromethyl) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Example 12 4- (2-Fluoro-6-methoxyphenyl) -6-methyl-N- (5- (trifluoromethyl) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Example 13 4- (2-Fluoro-6-methoxyphenyl) -6-methyl-N- (5- (pyridin-4-yl) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Step 1 5- (pyridin-4-yl) -1, 3, 4-thiadiazol-2-amine
  • Step 2 4- (2-fluoro-6-methoxyphenyl) -6-methyl-N- (5- (pyridin-4-yl) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Example 14 4- (2-Fluoro-6-methoxyphenyl) -N- (5- (4-methoxy-3-methylphenyl) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Step 1 5- (4-methoxy-3-methylphenyl) -1, 3, 4-thiadiazol-2-amine
  • Step 2 4- (2-fluoro-6-methoxyphenyl) -N- (5- (4-methoxy-3-methylphenyl) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Example 15 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -6-methyl-N- (5-methyl-1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Example 16 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5-cyclopropyl-1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Example 17 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5- (difluoromethyl) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Example 18 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5-isopropyl-1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Example 19 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5-ethyl-1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Example 20 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5- (1-fluorocyclopropyl) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Step 1 5- (1-fluorocyclopropyl) -1, 3, 4-thiadiazol-2-amine
  • Step 2 4- (3-chloro-2-fluoro-6-methoxyphenyl) -N- (5- (1-fluorocyclopropyl) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Example 21 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5- (1, 1-difluoroethyl) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Step 1 5- (1, 1-difluoroethyl) -1, 3, 4-thiadiazol-2-amine
  • Step 2 4- (3-chloro-2-fluoro-6-methoxyphenyl) -N- (5- (1, 1-difluoroethyl) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • This compound was prepared using procedures analogous to those described for Example 1 Step 3 using intermediate 4- (3-chloro-2-fluoro-6-methoxyphenyl) -6-methylnicotinic acid (Int-1) and 5- (1, 1-difluoroethyl) -1, 3, 4-thiadiazol-2-amine.
  • Step 1 methyl 2'-chloro-5'-methoxy-6-methyl- [4, 4'-bipyridine] -3-carboxylate
  • Step 2 2'-chloro-5'-methoxy-6-methyl- [4, 4'-bipyridine] -3-carboxylic acid
  • Step 3 2'-chloro-N- (5- (ethylthio) -1, 3, 4-thiadiazol-2-yl) -5'-methoxy-6-methyl- [4, 4'-bipyridine] -3-carboxamide
  • Example 23 4- (2, 3-Difluoro-6-methoxyphenyl) -6-methyl-N- (5- ( ( (tetrahydro-2H-pyran-3-yl) oxy) methyl) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Example 24 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5- (methoxymethyl) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Example 25 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5- (ethoxymethyl) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Step 2 4- (3-chloro-2-fluoro-6-methoxyphenyl) -N- (5- (ethoxymethyl) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Example 26 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -6-methyl-N- (5- ( (2, 2, 2-trifluoroethoxy) methyl) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Step 1 5- ( (2, 2, 2-trifluoroethoxy) methyl) -1, 3, 4-thiadiazol-2-amine
  • Step 2 4- (3-chloro-2-fluoro-6-methoxyphenyl) -6-methyl-N- (5- ( (2, 2, 2-trifluoroethoxy) methyl) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Example 27 4- (2-Fluoro-6-methoxy-3-methylphenyl) -6-methyl-N- (5- ( ( (tetrahydro-2H-pyran-3-yl) oxy) methyl) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Example 28 4- (2-Fluoro-6-methoxy-3- (trifluoromethyl) phenyl) -6-methyl-N- (5- ( ( (tetrahydro-2H-pyran-3-yl) oxy) methyl) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Example 29 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5- ( (2-methoxyethyl) thio) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Step 1 5- ( (2-methoxyethyl) thio) -1, 3, 4-thiadiazol-2-amine
  • Step 2 4- (3-chloro-2-fluoro-6-methoxyphenyl) -N- (5- ( (2-methoxyethyl) thio) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Example 30 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5- (ethylthio) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Step 2 4- (3-chloro-2-fluoro-6-methoxyphenyl) -N- (5- (ethylthio) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Example 31 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -6-methyl-N- (5- ( (2, 2, 2-trifluoroethyl) thio) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Step 1 5- ( (2, 2, 2-trifluoroethyl) thio) -1, 3, 4-thiadiazol-2-amine
  • Step 2 4- (3-chloro-2-fluoro-6-methoxyphenyl) -6-methyl-N- (5- ( (2, 2, 2-trifluoroethyl) thio) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Example 32 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5- ( (2-hydroxyethyl) thio) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Step 1 5- ( (2- ( (tert-butyldimethylsilyl) oxy) ethyl) thio) -1, 3, 4-thiadiazol-2-amine
  • Step 2 N- (5- ( (2- ( (tert-butyldimethylsilyl) oxy) ethyl) thio) -1, 3, 4-thiadiazol-2-yl) -4- (3-chloro-2-fluoro-6-methoxyphenyl) -6-methylnicotinamide
  • Step 3 4- (3-chloro-2-fluoro-6-methoxyphenyl) -N- (5- ( (2-hydroxyethyl) thio) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Example 33 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5- ( (3-hydroxypropyl) thio) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Example 34 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5- ( (3-hydroxy-3-methylbutyl) thio) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Step 1 4- ( (5-amino-1, 3, 4-thiadiazol-2-yl) thio) -2-methylbutan-2-ol
  • Step 2 4- (3-chloro-2-fluoro-6-methoxyphenyl) -N- (5- ( (3-hydroxy-3-methylbutyl) thio) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Example 35 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5- ( (2-hydroxypropyl) thio) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Example 36 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5- ( (3-cyanopropyl) thio) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Step 1 4- ( (5-amino-1, 3, 4-thiadiazol-2-yl) thio) butanenitrile
  • Step 2 4- (3-chloro-2-fluoro-6-methoxyphenyl) -6-methyl-N- (5- ( (2, 2, 2-trifluoroethyl) thio) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Example 37 trans-4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5- ( (-2-hydroxycyclopentyl) thio) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Step 1 trans-2- ( (5-amino-1, 3, 4-thiadiazol-2-yl) thio) cyclopentan-1-ol
  • Step 2 trans-4- (3-chloro-2-fluoro-6-methoxyphenyl) -N- (5- ( (-2-hydroxycyclopentyl) thio) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Example 38 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5- (dimethylamino) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Step 1 N 2 , N 2 -dimethyl-1, 3, 4-thiadiazole-2, 5-diamine
  • Step 2 4- (3-chloro-2-fluoro-6-methoxyphenyl) -N- (5- (dimethylamino) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Example 39 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -6-methyl-N- (5- (methyl (2- (N-methylacetamido) ethyl) amino) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Step 1 tert-butyl (2- ( (5-amino-1, 3, 4-thiadiazol-2-yl) (methyl) amino) ethyl) (methyl) carbamate
  • Step 2 tert-butyl (2- ( (5- (4- (3-chloro-2-fluoro-6-methoxyphenyl) -6-methylnicotinamido) -1, 3, 4-thiadiazol-2-yl) (methyl) amino) ethyl) (methyl) carbamate
  • Step 3 4- (3-chloro-2-fluoro-6-methoxyphenyl) -6-methyl-N- (5- (methyl (2- (methylamino) ethyl) amino) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Step 4 4- (3-chloro-2-fluoro-6-methoxyphenyl) -6-methyl-N- (5- (methyl (2- (N-methylacetamido) ethyl) amino) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Example 40 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5- ( (2-methoxyethyl) (methyl) amino) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Example 41 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -6-methyl-N- (5- (methyl (2, 2, 2-trifluoroethyl) amino) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Example 42 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5- ( (2-methoxyethyl) amino) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Example 43 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -6-methyl-N- (5- ( (2, 2, 2-trifluoroethyl) amino) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Example 44 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -6-methyl-N- (5- (4-methyl-2-oxopiperazin-1-yl) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Step 1 1- (5-amino-1, 3, 4-thiadiazol-2-yl) -4-methylpiperazin-2-one
  • Step 2 4- (3-chloro-2-fluoro-6-methoxyphenyl) -6-methyl-N- (5- (4-methyl-2-oxopiperazin-1-yl) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Example 45 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -6-methyl-N- (5- (methyl (2- (N-methylmethylsulfonamido) ethyl) amino) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Example 46 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5- ( (2- ( (N, N-dimethylsulfamoyl) (methyl) amino) ethyl) (methyl) amino) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Example 47 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -6-methyl-N- (5- (4-methyl-3-oxopiperazin-1-yl) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Example 48 Ethyl 2- (5- (4- (3-chloro-2-fluoro-6-methoxyphenyl) -6-methylnicotinamido) -1, 3, 4-thiadiazol-2-yl) -2, 2-difluoroacetate
  • Step 1 ethyl 2- (5-amino-1, 3, 4-thiadiazol-2-yl) -2, 2-difluoroacetate
  • Step 2 ethyl 2- (5- (4- (3-chloro-2-fluoro-6-methoxyphenyl) -6-methylnicotinamido) -1, 3, 4-thiadiazol-2-yl) -2, 2-difluoroacetate
  • Example 49 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5- (1, 1-difluoro-2-hydroxyethyl) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Example 50 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5- (1, 1-difluoro-3-hydroxypropyl) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Step 1 5- (1, 1-difluorobut-3-en-1-yl) -1, 3, 4-thiadiazol-2-amine
  • Step 2 3- (5-amino-1, 3, 4-thiadiazol-2-yl) -3, 3-difluoropropan-1-ol
  • Step 3 4- (3-chloro-2-fluoro-6-methoxyphenyl) -N- (5- (1, 1-difluoro-3-hydroxypropyl) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Example 51 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5- (1, 1-difluorobut-3-en-1-yl) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Example 52 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5- (1, 1-difluorobutyl) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Example 53 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5- (ethylsulfonyl) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Example 54 2- (5- (4- (3-Chloro-2-fluoro-6-methoxyphenyl) -6-methylnicotinamido) -1, 3, 4-thiadiazol-2-yl) -2, 2-difluoroacetic acid
  • Example 55 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5- (1, 1-difluoro-2- (methylsulfonamido) -2-oxoethyl) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Example 56 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5- (2- (dimethylamino) -1, 1-difluoro-2-oxoethyl) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Example 57-100 listed in Table 1 below were prepared by using an intermediate ethyl 2- (5- (4- (3-chloro-2-fluoro-6-methoxyphenyl) -6-methylnicotinamido) -1, 3, 4-thiadiazol-2-yl) -2, 2-difluoroacetate (Example 48) and an appropriate amine derivative as the methods analogous to those described for preparing Example 56.
  • Example 101 N- (5- (2- (2-oxa-5-azabicyclo [2.2.1] heptan-5-yl) -1, 1-difluoro-2-oxoethyl) -1, 3, 4-thiadiazol-2-yl) -4- (3-chloro-2-fluoro-6-methoxyphenyl) -6-methylnicotinamide
  • Step 1 2- (5- (4- (3-chloro-2-fluoro-6-methoxyphenyl) -6-methylnicotinamido) -1, 3, 4-thiadiazol-2-yl) -2, 2-difluoroacetyl chloride
  • Step 2 N- (5- (2- (2-oxa-5-azabicyclo [2.2.1] heptan-5-yl) -1, 1-difluoro-2-oxoethyl) -1, 3, 4-thiadiazol-2-yl) -4- (3-chloro-2-fluoro-6-methoxyphenyl) -6-methylnicotinamide
  • Example 102-107 listed in Table 2 below were prepared by using an intermediate 2- (5- (4- (3-chloro-2-fluoro-6-methoxyphenyl) -6-methylnicotinamido) -1, 3, 4-thiadiazol-2-yl) -2, 2-difluoroacetyl chloride (Example 101 Step 1) and an appropriate amine derivative or HCl salt thereof as the methods analogous to those described for preparing Example 101.
  • Example 108 N- (5- (2- (Dimethylamino) -1, 1-difluoro-2-oxoethyl) -1, 3, 4-thiadiazol-2-yl) -4- (2-fluoro-6-methoxy-3-methylphenyl) -6-methylnicotinamide
  • Step 1 ethyl 2, 2-difluoro-2- (5- (4- (2-fluoro-6-methoxy-3-methylphenyl) -6-methylnicotinamido) -1, 3, 4-thiadiazol-2-yl) acetate
  • Step 2 N- (5- (2- (dimethylamino) -1, 1-difluoro-2-oxoethyl) -1, 3, 4-thiadiazol-2-yl) -4- (2-fluoro-6-methoxy-3-methylphenyl) -6-methylnicotinamide
  • Example 109 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5- (1, 1-difluoro-2- ( (7S, 8aS) -7- hydroxyhexahydropyrrolo [1, 2-a] pyrazin-2 (1H) -yl) -2-oxoethyl) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Step 1 tert-butyl (7S, 8aS) -7- ( (4-nitrobenzoyl) oxy) hexahydropyrrolo [1, 2-a] pyrazine-2 (1H) -carboxylate
  • Step 2 tert-butyl (7S, 8aS) -7-hydroxyhexahydropyrrolo [1, 2-a] pyrazine-2 (1H) -carboxylate
  • Step 4 4- (3-chloro-2-fluoro-6-methoxyphenyl) -N- (5- (1, 1-difluoro-2- ( (7S, 8aS) -7-hydroxyhexahydropyrrolo [1, 2-a] pyrazin-2 (1H) -yl) -2-oxoethyl) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Example 110 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5- (1, 1-difluoro-2-hydroxyethyl-2, 2-d2) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Example 111 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -6-methyl-N- (5- (perfluoroethyl) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Step 1 5- (perfluoroethyl) -1, 3, 4-thiadiazol-2-amine
  • Step 2 4- (3-chloro-2-fluoro-6-methoxyphenyl) -6-methyl-N- (5- (perfluoroethyl) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Example 112 3- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5- (1, 1-difluoroethyl) -1, 3, 4-thiadiazol-2-yl) isonicotinamide
  • Step 1 methyl 3- (3-chloro-2-fluoro-6-methoxyphenyl) isonicotinate
  • Step 3 3- (3-chloro-2-fluoro-6-methoxyphenyl) -N- (5- (1, 1-difluoroethyl) -1, 3, 4-thiadiazol-2-yl) isonicotinamide
  • Example 113 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5- (1, 1-difluoroethyl) -1, 3, 4-thiadiazol-2-yl) -6- (1-methyl-1H-pyrazol-3-yl) nicotinamide
  • Step 1 methyl 6-chloro-4- (3-chloro-2-fluoro-6-methoxyphenyl) nicotinate
  • Step 2 methyl 4- (3-chloro-2-fluoro-6-methoxyphenyl) -6- (1-methyl-1H-pyrazol-3-yl) nicotinate
  • Step 3 4- (3-chloro-2-fluoro-6-methoxyphenyl) -6- (1-methyl-1H-pyrazol-3-yl) nicotinic acid
  • Step 4 4- (3-chloro-2-fluoro-6-methoxyphenyl) -N- (5- (1, 1-difluoroethyl) -1, 3, 4-thiadiazol-2-yl) -6- (1-methyl-1H-pyrazol-3-yl) nicotinamide
  • Example 114 Ethyl 2- ( (5- (4- (3-chloro-2-fluoro-6-methoxyphenyl) -6-methylnicotinamido) -1, 3, 4-thiadiazol-2-yl) thio) propanoate
  • Step 1 ethyl 2- ( (5-amino-1, 3, 4-thiadiazol-2-yl) thio) propanoate
  • Step 2 ethyl 2- ( (5- (4- (3-chloro-2-fluoro-6-methoxyphenyl) -6-methylnicotinamido) -1, 3, 4-thiadiazol-2-yl) thio) propanoate
  • Example 115 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5- ( (1-hydroxypropan-2-yl) thio) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Example 116 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5- ( (1- (dimethylamino) -1-oxopropan-2-yl) thio) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Step 1 2- ( (5- (4- (3-chloro-2-fluoro-6-methoxyphenyl) -6-methylnicotinamido) -1, 3, 4-thiadiazol-2-yl) thio) propanoic acid
  • Step 2 4- (3-chloro-2-fluoro-6-methoxyphenyl) -N- (5- ( (1- (dimethylamino) -1-oxopropan-2-yl) thio) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Step 1 2- ( (5-amino-1, 3, 4-thiadiazol-2-yl) thio) ethan-1-ol
  • Step 2 methyl 4- (2-methoxyphenyl) -6-methylnicotinate
  • Step 3 4- (2-methoxyphenyl) -6-methylnicotinic acid
  • Step 4 N- (5- ( (2-hydroxyethyl) thio) -1, 3, 4-thiadiazol-2-yl) -4- (2-methoxyphenyl) -6-methylnicotinamide
  • Example 118 4- (5-Chloro-2-methoxyphenyl) -N- (5- ( (2-hydroxyethyl) thio) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Step 3 methyl 6-cyano-2- (2-methoxyphenyl) nicotinate
  • Step 4 6-cyano-2- (2-methoxyphenyl) nicotinic acid
  • Step 5 6-cyano-N- (5- ( (2-hydroxyethyl) thio) -1, 3, 4-thiadiazol-2-yl) -2- (2-methoxyphenyl) nicotinamide
  • Example 120 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -6-cyano-N- (5- ( (2-hydroxyethyl) thio) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Step 1 methyl 4- (3-chloro-2-fluoro-6-methoxyphenyl) -6-cyanonicotinate
  • Step 2 4- (3-chloro-2-fluoro-6-methoxyphenyl) -6-cyanonicotinic acid
  • Step 3 4- (3-chloro-2-fluoro-6-methoxyphenyl) -6-cyano-N- (5- ( (2-hydroxyethyl) thio) -1, 3, 4-thiadiazol-2-yl) nicotinamide
  • Step 1 ethyl 1- (2-methoxyphenyl) -1H-imidazole-5-carboxylate
  • Step 2 1- (2-methoxyphenyl) -1H-imidazole-5-carboxylic acid
  • Step 3 N- (5- ( (2-hydroxyethyl) thio) -1, 3, 4-thiadiazol-2-yl) -1- (2-methoxyphenyl) -1H-imidazole-5-carboxamide
  • Example 122 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5- ( ( (5-chloropyridin-2-yl) oxy) difluoromethyl) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Step 1 cesium 2- ( (5-chloropyridin-2-yl) oxy) -2, 2-difluoroacetate
  • Step 2 5- ( ( (5-chloropyridin-2-yl) oxy) difluoromethyl) -1, 3, 4-thiadiazol-2-amine
  • Step 3 4- (3-chloro-2-fluoro-6-methoxyphenyl) -N- (5- ( ( (5-chloropyridin-2-yl) oxy) difluoromethyl) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Example 123 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5- ( ( (S) -2-hydroxypropyl) thio) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Step 1 (S) -1- ( (5-amino-1, 3, 4-thiadiazol-2-yl) thio) propan-2-ol
  • Step 2 4- (3-chloro-2-fluoro-6-methoxyphenyl) -N- (5- ( ( (S) -2-hydroxypropyl) thio) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Example 124 4- (3-Chloro-2-fluoro-6-methoxyphenyl) -N- (5- ( ( (R) -2-hydroxypropyl) thio) -1, 3, 4-thiadiazol-2-yl) -6-methylnicotinamide
  • Step 1 methyl 5-chloro-2-methoxy-6'-methyl- [3, 4'-bipyridine] -3'-carboxylate
  • Step 2 5-chloro-2-methoxy-6'-methyl- [3, 4'-bipyridine] -3'-carboxylic acid
  • Step 3 5-chloro-N- (5- (1, 1-difluoroethyl) -1, 3, 4-thiadiazol-2-yl) -2-methoxy-6'-methyl- [3, 4'-bipyridine] -3'-carboxamide
  • Step 1 (3-chloro-2-fluoro-6-methoxyphenyl) boronic acid
  • Step 2 methyl 4- (3-chloro-2-fluoro-6-methoxyphenyl) -6-methylnicotinate
  • Step 3 4- (3-chloro-2-fluoro-6-methoxyphenyl) -6-methylnicotinic acid
  • Step 1 methyl 4- (2-fluoro-6-methoxyphenyl) -6-methylnicotinate
  • Step 2 4- (2-fluoro-6-methoxyphenyl) -6-methylnicotinic acid
  • Step 1 methyl 4- (2, 3-difluoro-6-methoxyphenyl) -6-methylnicotinate
  • Step 2 4- (2, 3-difluoro-6-methoxyphenyl) -6-methylnicotinic acid
  • Step 1 methyl 4- (2-fluoro-6-methoxy-3-methylphenyl) -6-methylnicotinate
  • Step 2 4- (2-fluoro-6-methoxy-3-methylphenyl) -6-methylnicotinic acid
  • Step 1 2- (3-fluoro-4- (trifluoromethyl) phenyl) -4, 4, 5, 5-tetramethyl-1, 3, 2-dioxaborolane
  • Step 4 (2-fluoro-6-methoxy-3- (trifluoromethyl) phenyl) boronic acid
  • reaction mixture was quenched by aq HCl (2 M) solution (20 mL) at 0 °C, stirred for 30 min., and extracted with EtOAc (40 mL x 5) .
  • EtOAc 40 mL x 5
  • the combined organic layers were washed with brine (40 mL) , dried over Na 2 SO 4 , filtered and concentrated under reduced pressure to afford the title compoud (2.0 g, 42%) as a yellow oil without further purification.
  • Step 5 methyl 4- (2-fluoro-6-methoxy-3- (trifluoromethyl) phenyl) -6-methylnicotinate
  • Step 6 4- (2-fluoro-6-methoxy-3- (trifluoromethyl) phenyl) -6-methylnicotinic acid
  • Example A Biological evaluation
  • PolQ ATPase activity was determined by ADP-Glo assay. 10-point dilution series of compounds were used in a 384 well format for the inhibition assays.
  • PolQ (1-899) (1 nM) in assay buffer (20 mM Tris HCl (pH 8.0) , 80 mM KCl, 10 mM MgCl 2 , 1 mM DTT, 0.01%BSA, 0.01%Tween, 5%glycerol) was transferred to the test wells (20 uL) , except the low control wells (20 ⁇ L of assay buffer was added to the low control wells) . The plate was then incubated at room temperature for 30 min.
  • IC 50 values were calculated using a four-parameter logistic curve fit using the following formula:
  • IC 50 values were determined by fitting the data to the standard 4 parameters with Hill Slope using GraphPad Prism software. IC 50 : * ⁇ 10nM, 10nM ⁇ ** ⁇ 100nM, 100nM ⁇ *** ⁇ 500nM, ****>500nM. The experimental results of the compounds are described in Table 4.

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Abstract

L'invention concerne des dérivés de thiadiazolyle, par exemple, un composé de formule (I), et des compositions pharmaceutiques de ceux-ci. L'invention concerne également leurs utilisations dans le traitement d'une maladie médiée par PolQ, par exemple, un cancer caractérisé par un défaut de réparation de l'ADN.
PCT/CN2023/130329 2022-11-10 2023-11-08 Dérivés de thiadiazolyle, compositions et utilisations associées WO2024099337A1 (fr)

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CN2023079231 2023-03-02
CNPCT/CN2023/082601 2023-03-20
CN2023082601 2023-03-20
CNPCT/CN2023/088521 2023-04-14
CN2023088521 2023-04-14
CNPCT/CN2023/096096 2023-05-24
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CN2023097515 2023-05-31
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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140221411A1 (en) * 2011-10-21 2014-08-07 Korea Research Institute Of Bioscience And Biotechnology 2-hydroxyarylamide derivative or pharmaceutically acceptable salt thereof, preparation method thereof, and pharmaceutical composition for preventing or treating cancer containing same as active ingredient
CN114127062A (zh) * 2019-05-31 2022-03-01 伊迪亚生物科学有限公司 作为DNA聚合酶Theta抑制剂的噻二唑基衍生物
WO2022118210A1 (fr) * 2020-12-02 2022-06-09 Ideaya Biosciences, Inc. Dérivés substitués de thiadiazolyle comme inhibiteurs de l'adn polymérase thêta
WO2023050007A1 (fr) * 2021-09-29 2023-04-06 Repare Therapeutics Inc. Composés n-([(l,3,4-thiadiazolyle) ou (thiazolyle)]-5-substitués)carboxamide (substitué) et leur utilisation pour inhiber la polymérase thêta humaine
WO2023060573A1 (fr) * 2021-10-15 2023-04-20 Beijing Danatlas Pharmaceutical Co., Ltd. Nouveaux dérivés du type thiadiazolyle d'inhibiteurs de l'adn polymérase thêta
WO2023067515A1 (fr) * 2021-10-22 2023-04-27 Ideaya Biosciences, Inc. Composés thiadiazolyles utilisés comme inhibiteurs de l'adn polymérase thêta
WO2023202623A1 (fr) * 2022-04-20 2023-10-26 南京再明医药有限公司 Composé inhibiteur de polq et son utilisation

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140221411A1 (en) * 2011-10-21 2014-08-07 Korea Research Institute Of Bioscience And Biotechnology 2-hydroxyarylamide derivative or pharmaceutically acceptable salt thereof, preparation method thereof, and pharmaceutical composition for preventing or treating cancer containing same as active ingredient
CN114127062A (zh) * 2019-05-31 2022-03-01 伊迪亚生物科学有限公司 作为DNA聚合酶Theta抑制剂的噻二唑基衍生物
WO2022118210A1 (fr) * 2020-12-02 2022-06-09 Ideaya Biosciences, Inc. Dérivés substitués de thiadiazolyle comme inhibiteurs de l'adn polymérase thêta
WO2023050007A1 (fr) * 2021-09-29 2023-04-06 Repare Therapeutics Inc. Composés n-([(l,3,4-thiadiazolyle) ou (thiazolyle)]-5-substitués)carboxamide (substitué) et leur utilisation pour inhiber la polymérase thêta humaine
WO2023060573A1 (fr) * 2021-10-15 2023-04-20 Beijing Danatlas Pharmaceutical Co., Ltd. Nouveaux dérivés du type thiadiazolyle d'inhibiteurs de l'adn polymérase thêta
WO2023061415A1 (fr) * 2021-10-15 2023-04-20 Danatlas Pharmaceuticals Co., Ltd. Dérivés de thiadiazolyle, compositions et utilisations de ceux-ci
WO2023067515A1 (fr) * 2021-10-22 2023-04-27 Ideaya Biosciences, Inc. Composés thiadiazolyles utilisés comme inhibiteurs de l'adn polymérase thêta
WO2023202623A1 (fr) * 2022-04-20 2023-10-26 南京再明医药有限公司 Composé inhibiteur de polq et son utilisation

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