WO2023248722A1 - 薬液注入ユニット - Google Patents

薬液注入ユニット Download PDF

Info

Publication number
WO2023248722A1
WO2023248722A1 PCT/JP2023/019863 JP2023019863W WO2023248722A1 WO 2023248722 A1 WO2023248722 A1 WO 2023248722A1 JP 2023019863 W JP2023019863 W JP 2023019863W WO 2023248722 A1 WO2023248722 A1 WO 2023248722A1
Authority
WO
WIPO (PCT)
Prior art keywords
tube
injection unit
ports
puncture catheter
support wire
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2023/019863
Other languages
English (en)
French (fr)
Japanese (ja)
Inventor
光太郎 水上
俊彦 塚本
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Intecc Co Ltd
Original Assignee
Asahi Intecc Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Intecc Co Ltd filed Critical Asahi Intecc Co Ltd
Publication of WO2023248722A1 publication Critical patent/WO2023248722A1/ja
Priority to US18/985,494 priority Critical patent/US20250114573A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0082—Catheter tip comprising a tool
    • A61M25/0084—Catheter tip comprising a tool being one or more injection needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/06—Body-piercing guide needles or the like
    • A61M25/0662—Guide tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/34—Trocars; Puncturing needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A61M25/0026—Multi-lumen catheters with stationary elements
    • A61M25/003—Multi-lumen catheters with stationary elements characterized by features relating to least one lumen located at the distal part of the catheter, e.g. filters, plugs or valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/0105—Steering means as part of the catheter or advancing means; Markers for positioning
    • A61M25/0108—Steering means as part of the catheter or advancing means; Markers for positioning using radio-opaque or ultrasound markers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/02—Holding devices, e.g. on the body
    • A61M25/04—Holding devices, e.g. on the body in the body, e.g. expansible
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0082—Catheter tip comprising a tool
    • A61M25/0084—Catheter tip comprising a tool being one or more injection needles
    • A61M2025/0087—Multiple injection needles protruding laterally from the distal tip
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M2025/0183—Rapid exchange or monorail catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/0007—Special media to be introduced, removed or treated introduced into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/32—General characteristics of the apparatus with radio-opaque indicia

Definitions

  • the present invention relates to a liquid drug injection unit.
  • treatment has been performed by inserting catheter-like medical instruments into tubular organs of the human body, such as blood vessels and the digestive tract.
  • treatment has also been performed by injecting a medicinal solution into internal tissue (treatment site) using a catheter-like medical device capable of injecting a medicinal solution.
  • a puncture needle at the tip of the catheter is delivered to the outside of the catheter tube through an opening or hole provided on the outer circumferential surface of the catheter tube, and the puncture needle is delivered to the outside of the catheter tube. is injected.
  • Patent Document 1 discloses that a needle portion of a needle-like tube body (catheter) is made to protrude from a protrusion hole provided in one side of a tubular body (catheter tube) to puncture a predetermined tissue in the body. discloses a liquid medicine injector capable of injecting the liquid medicine into the body tissue through the needle-like tube.
  • the catheter tube When attempting to inject a medical solution into a specific body tissue that is a treatment site using a catheter tube having holes in one side direction as shown in Patent Document 1, the catheter tube may be inserted into the blood vessel depending on the position of the body tissue. need to be rotated. Furthermore, there is a risk of the catheter tube moving away from the blood vessel due to the repulsive force when the puncture needle punctures the body tissue, which poses safety concerns.
  • the present invention was made in view of the above-mentioned problems, and an object of the present invention is to provide a chemical liquid injection unit with improved handling and safety.
  • the present invention first includes a long tube, the tube extends in the axial direction of the tube, and has a center lumen into which a puncture catheter having a puncture needle at the tip can be inserted; at least three puncture catheter ports that communicate with the center lumen and open at different positions in the circumferential direction on the outer circumferential surface of the tube, and located at positions facing each of the at least three puncture catheter ports with respect to the axis of the tube.
  • a drug solution injection unit is provided (invention 1), which includes a support mechanism arranged and used to support the tube.
  • the puncture catheter port by selecting the puncture catheter port closest to the body tissue into which the drug solution needs to be injected from at least three puncture catheter ports and inserting the puncture catheter there, the puncture catheter port is inserted into the blood vessel.
  • a medical solution can be injected into the body tissue without rotating the catheter.
  • the support mechanism disposed at positions facing each of the at least three puncture catheter ports suppresses the liquid injection unit from moving away from the blood vessel due to the repulsive force when puncturing the body tissue with the puncture needle. be able to. That is, according to the invention (invention 1), it is possible to provide a drug solution injection unit with improved handling properties and safety.
  • the support mechanism extends in the axial direction of the tube and includes at least three support wire lumens into which at least one support wire can be inserted, and each of the at least three support wire lumens. and at least three support wire ports that communicate with the tube and open at different positions in the circumferential direction on the outer peripheral surface of the tube (invention 2).
  • a support wire port is selected that is located at a position opposite to the puncture catheter port through which the puncture catheter is sent out, with respect to the axis of the tube, and the support wire is sent out from this support wire port.
  • the at least three puncture catheter ports may be arranged at equal intervals in the circumferential direction on the outer peripheral surface of the tube (Invention 3).
  • the at least three puncture catheter ports may be arranged at different positions in the longitudinal direction on the outer peripheral surface of the tube (Invention 4).
  • invention 4 it is possible to more appropriately select the puncture catheter port closest to the internal tissue into which the drug solution needs to be injected.
  • the at least three puncture catheter ports may be arranged at equal intervals in the longitudinal direction on the outer peripheral surface of the tube (invention 5).
  • invention 4 it is possible to more appropriately select the puncture catheter port closest to the internal tissue into which the drug solution needs to be injected.
  • invention 1-5) may include a plurality of puncture catheter sets including the at least three puncture catheter ports, and the plurality of puncture catheter sets may be arranged at different positions in the longitudinal direction of the tube ( Invention 6).
  • the drug solution can be more easily injected into multiple locations in the body tissue where the drug solution needs to be injected, without moving the drug solution injection unit back and forth within the blood vessel.
  • an X-ray opaque marker may be placed on at least a portion of the outer periphery of each of the at least three puncture catheter ports (Invention 7).
  • the position of each puncture catheter port can be easily confirmed using X-rays.
  • the support mechanism may include a balloon member having a balloon (invention 8).
  • a balloon member located at a position opposite to the axis of the tube and the puncture catheter port through which the puncture catheter is delivered is selected as the support mechanism, and the balloon of this balloon member is inflated.
  • the repulsive force generated when the puncture needle of the puncture catheter is inserted into a body tissue into which a medical solution needs to be injected can suppress the medical solution injection unit from moving away from the blood vessel.
  • the present invention it is possible to puncture a plurality of puncture target sites with a puncture needle without rotating the catheter within a blood vessel. Therefore, according to the present invention, it is possible to provide a chemical liquid injection unit with improved handling properties and safety.
  • FIG. 1 is a schematic explanatory diagram showing the structure of a liquid medicine injection unit according to an embodiment of the present invention.
  • FIG. 2 is a transparent perspective view schematically showing a part of a tube included in the chemical liquid injection unit of FIG. 1.
  • FIG. It is a figure which shows an example when the puncture catheter and support wire are inserted into the tube of FIG. 2A, together with a blood vessel.
  • FIG. 2B is an axial vertical projection of the tube of FIG. 2A;
  • FIG. 2B is an axial vertical projection of the tube of FIG. 2B;
  • FIG. 2B is a diagram illustrating an example of placing a radiopaque marker on the puncture catheter port of the tube of FIG. 2A.
  • FIG. 2A is a diagram showing another example of placing a radiopaque marker on the puncture catheter port of the tube of FIG. 2A.
  • FIG. FIG. 7 is a transparent perspective view schematically showing a part of a tube and a distal end portion of a chemical liquid injection unit of Modification 1.
  • FIG. 5A is a diagram showing an example of when a guide wire is inserted into the tube of FIG. 5A.
  • FIG. FIG. 7 is a transparent perspective view schematically showing a part of a tube included in a chemical liquid injection unit of Modification 2.
  • FIG. 6A is a diagram showing an example of when a puncture catheter and a support wire are inserted into the tube of FIG. 6A.
  • FIG. FIG. 6B is an axial vertical projection of the tube of FIG. 6A;
  • FIG. 6B is a perpendicular axial projection of the tube of FIG. 6B;
  • FIG. 7 is a transparent perspective view schematically showing a part of a tube included in a chemical liquid injection unit of Modification 3.
  • FIG. 7 is a schematic explanatory diagram showing the structure of a chemical liquid injection unit of Modification 4.
  • 10 is a transparent perspective view schematically showing a part of a tube and a balloon member included in the chemical liquid injection unit of FIG. 9.
  • FIG. 10 is a diagram showing a vertical projection view of the tube of FIG. 9 in the axial direction together with a balloon member.
  • FIG. 1 is a schematic explanatory diagram showing the structure of a chemical liquid injection unit 1 according to an embodiment of the present invention.
  • the drug solution injection unit 1 includes a long tube 10.
  • the drug solution injection unit 1 is a drug solution injection catheter used to inject a drug solution into a specific body tissue that is a treatment site.
  • the drug solution injection unit 1 is inserted, for example, into a blood vessel of a heart that has suffered a myocardial infarction, and is used to inject cultured myocardial cells into a specific myocardium.
  • distal end side is a direction along the axis X direction of the tube 10 constituting the drug solution injection unit 1, in which the drug solution injection unit 1 advances toward a specific body tissue that is a treatment site. means direction.
  • proximal side refers to a direction along the axis X direction of the tube 10 constituting the drug solution injection unit 1, and means a direction opposite to the distal end side.
  • distal end refers to the distal end of any member or site
  • base end refers to the proximal end of any member or site.
  • the left side of the figure is the “distal side” that is inserted into the body
  • the right side of the figure is the "proximal side” that is operated by the operator.
  • the drug solution injection unit 1 further includes a distal end portion 20 connected to the distal end of the tube 10, and a branch socket 30 connected to the proximal end of the tube 10.
  • FIG. 2A is a transparent perspective view schematically showing a part of the tube 10 included in the chemical liquid injection unit 1 of FIG. 1.
  • FIG. 2A generally corresponds to the portion indicated by the symbol A in FIG.
  • the tube 10 includes a center lumen 11 extending in the direction of the axis X of the tube 10, and at least three puncture catheter ports 12a to 12c that open at different positions in the circumferential direction on the outer peripheral surface 10s of the tube 10.
  • a support mechanism 40 is provided, which is arranged at a position facing each of the at least three puncture catheter ports 12a to 12c with respect to the axis X of the tube 10, and is used to support the tube 10.
  • the center lumen 11 is a lumen into which a puncture catheter Cp having a puncture needle at its tip can be inserted. Puncture catheter ports 12a to 12c each communicate with one common center lumen 11.
  • the support mechanism 40 disposed at a position facing each of at least three puncture catheter ports 12a to 12c with respect to the axis X of the tube 10 refers to a vertical projection view of the tube 10 in the axis X direction. , which means that the support mechanism 40 is disposed at a position facing each of the puncture catheter ports 12a to 12c with respect to the axis X of the tube 10.
  • "Vertical projection of the tube 10 in the axis X direction” means a projection of the tube 10 onto a plane orthogonal to the axis X of the tube 10.
  • the support mechanism 40 includes at least three support wire lumens 13a to 13c extending in the direction of the axis X of the tube 10, and at least three support wire ports opening at different positions in the circumferential direction on the outer peripheral surface 10s of the tube 10. 14a to 14c.
  • Each of the support wire lumens 13a to 13c is a lumen into which at least one support wire Ws can be inserted.
  • Support wire ports 14a-14c communicate with support wire lumens 13a-13c, respectively.
  • FIG. 3A is a vertical projection view of the tube 10 of FIG. 2A in the axis X direction.
  • the center lumen 11 is located at the center so as to include the axis X of the tube 10.
  • the support wire lumens 13a to 13c are arranged outside the center lumen 11 so as to surround the center lumen 11.
  • the inner diameter of the center lumen 11 is configured to be larger than the inner diameter of the support wire lumens 13a to 13c.
  • the puncture catheter ports 12a to 12c and the support wire ports 14a to 14c are arranged at opposing positions with respect to the axis X of the tube 10" means that the puncture catheter ports 12a to 12c and the support wire ports 14a It is intended that the puncture catheter ports 12a to 12c and the support wire ports 14a to 14c are disposed in positions generally facing each other with respect to the axis It is not intended that the two be placed at positions directly opposite to the axis X.
  • the opening centers 14d of the support wire ports 14a to 14c are such that the angle ⁇ defined by the axis It may be located within a range that satisfies .
  • FIG. 2B is a diagram showing an example of when the puncture catheter Cp and the support wire Ws are inserted into the tube 10 of FIG. 2A, together with the blood vessel BV.
  • FIG. 3B is a vertical projection view of the tube 10 of FIG. 2B in the axis X direction. Note that the blood vessel BV is omitted in FIG. 3B.
  • the drug solution injection unit 1 selects one of at least three puncture catheter ports 12a to 12c that is closest to the body tissue into which the drug solution needs to be injected, and injects the drug solution there.
  • a puncture catheter Cp can be inserted.
  • the puncture catheter Cp has a puncture needle at its tip. Thereby, the drug solution can be injected into the body tissue without rotating the drug solution injection unit 1 within the blood vessel BV.
  • one of the puncture catheter ports 12a to 12c from which the puncture catheter Cp is delivered is connected to the axis X of the tube 10 from the support wire ports 14a to 14c.
  • Two or more of the at least three support wire ports 14a to 14c may be selected as the support wire ports 14a to 14c through which the support wire Ws1 is sent out. That is, by sending out the support wire Ws from each of two or more of the at least three support wire ports 14a to 14c, the liquid drug injection unit 1 may be prevented from moving away from the blood vessel BV. Furthermore, the liquid drug injection unit 1 may be prevented from moving away from the blood vessel BV by sending out two or more support wires Ws from one of the at least three support wire ports 14a to 14c.
  • At least three puncture catheter ports 12a to 12c may be arranged at equal intervals in the circumferential direction on the outer peripheral surface 10s of the tube 10.
  • three puncture catheter ports 12a to 12c are arranged at equal intervals in the circumferential direction on the outer peripheral surface 10s of the tube 10 so that the angle ⁇ defined by the straight line L and the axis X is 120°. ing. This makes it possible to more appropriately select one of the at least three puncture catheters 12a to 12c that is closest to the body tissue into which the drug solution needs to be injected.
  • At least three puncture catheter ports 12a to 12c may be arranged at different positions in the longitudinal direction on the outer peripheral surface 10s of the tube 10. This makes it possible to appropriately select one of the at least three puncture catheter ports 12a to 12c that is closest to the body tissue into which the drug solution needs to be injected.
  • At least three puncture catheter ports 12a to 12c may be arranged at equal intervals in the longitudinal direction on the outer peripheral surface 10s of the tube 10. This makes it possible to more appropriately select one of the at least three puncture catheter ports 12a to 12c that is closest to the body tissue into which the drug solution needs to be injected.
  • FIG. 4A is a diagram showing an example in which X-ray opaque markers 15 are placed in the puncture catheter ports 12a to 12c of the tube 10 in FIG. 2A.
  • FIG. 4B is a diagram showing another example in which radiopaque markers 15a to 15c are placed in the puncture catheter ports 12a to 12c of the tube 10 in FIG. 2A.
  • X-ray opaque markers 15a to 15c may be arranged on at least a portion of the outer periphery of each of the at least three puncture catheter ports 12a to 12c. Thereby, the position of each puncture catheter port 12a to 12c can be easily confirmed using X-rays.
  • the X-ray opaque markers 15a to 15c may be arranged so that the positions of the puncture catheter ports 12a to 12c can be confirmed by X-rays, and the method of arrangement thereof is not particularly limited.
  • radiopaque markers 15a-15c may be placed around the outer periphery of puncture catheter ports 12a-12c.
  • the radiopaque markers 15a to 15c may be arranged linearly in the tangential direction of the outer periphery of the puncture catheter ports 12a to 12c.
  • the tip portion 20 has a tip opening 21.
  • the tip opening 21 may communicate with the center lumen 11.
  • the guide wire Wg can be guided to the distal opening 21 of the distal end portion 20 via the center lumen 11. That is, in the drug solution injection unit 1, the center lumen 11 may also serve as a guide wire lumen into which the guide wire Wg can be inserted.
  • the branch socket 30 is configured so that three connectors (not shown) can be attached thereto.
  • the first and second connectors may correspond to and communicate with the center lumen 11, and the third connector may communicate with the support wire lumens 13a-13c.
  • the puncture catheter Cp inserted through the opening of the first connector can be guided through the center lumen 11 to one of the puncture catheter ports 12a to 12c, and The guide wire Wg inserted through the opening can be guided to the distal end opening 21 via the center lumen 11.
  • the support wire Ws inserted through the opening of the third connector can be guided to one of the support wire ports 14a to 14c via one of the support wire lumens 13a to 13c.
  • FIG. 5A is a transparent perspective view schematically showing a part of the tube 101 and the distal end portion 201 included in the chemical liquid injection unit 100 of Modification 1.
  • 5A generally corresponds to the portion indicated by the symbol B in FIG.
  • FIG. 5B is a diagram showing an example of when the guide wire Wg is inserted into the tube 101 of FIG. 5A.
  • the drug solution injection unit 100 may include, in addition to the center lumen 11, a guide wire lumen 16 into which a guide wire Wg can be inserted.
  • Guidewire lumen 16 extends in the axial direction of tube 101 and communicates with distal opening 21 of distal end portion 201 .
  • FIGS. 1 is a transparent perspective view schematically showing a part of the tube 101 and the distal end portion 201 included in the chemical liquid injection unit 100 of Modification 1.
  • 5A generally corresponds to the portion indicated by the symbol B in FIG.
  • FIG. 5B is a diagram showing an example of when the guide wire Wg is inserted into the tube 101 of FIG.
  • the guide wire port 17 communicating with the guide wire lumen 16 may be arranged on the outer circumferential surface 101s of the tube 101.
  • a plurality of guide wire ports 17 may exist at different positions in the circumferential direction of the tube 101.
  • Each of the plurality of guidewire ports 17 may communicate with one common center lumen 11.
  • the first connector is connected to correspond to the center lumen 11, and the second connector is connected to the guide wire lumen 16.
  • the third connector may be connected to the support wire lumens 13a to 13c.
  • the guidewire Wg inserted from the opening of the second connector can be guided to the distal end opening 21 via the guidewire lumen 16.
  • the inner diameter of the guide wire lumen 16 is configured to be larger than the inner diameter of the support wire lumens 13a to 13c.
  • the inner diameter of the guide wire lumen 16 and the inner diameter of the center lumen 11 may be the same or different.
  • the inner diameter of the guide wire lumen 16 may be configured to be smaller than the inner diameter of the center lumen 11.
  • FIG. 6A is a transparent perspective view schematically showing a part of the tube 102 included in the chemical liquid injection unit 200 of Modification 2.
  • the support mechanism 40 includes at least three first support wire lumens 13a to 13c extending in the direction of the axis X of the tube 102, and at least three first support wire lumens 13a to 13c extending in the direction of the axis First support wire ports 14a to 14c, at least three second support wire lumens 18a to 18c extending in the axis X direction of the tube 102, and at least three second support wire lumens 18a to 18c extending in the direction of the axis 2 support wire ports 19a-19c.
  • the first support wire lumens 13a-13c correspond to the support wire lumens 13a-13c described above.
  • the first support wire ports 14a-14c correspond to the support wire ports 14a-14c described above.
  • the second support wire lumens 18a to 18c are each lumens into which at least one support wire Ws can be inserted.
  • Second support wire ports 19a-19c communicate with second support wire lumens 18a-18c, respectively.
  • FIG. 7A is a vertical projection view of the tube 102 in FIG. 6A in the axis X direction.
  • the second support wire lumens 18a to 18c are located at different positions in the axis
  • the support wire lumens 13a to 13c are arranged at positions that do not overlap with the first support wire lumens 13a to 13c.
  • the second support wire lumens 18a to 18c are arranged outside the center lumen 11 so as to surround the center lumen 11.
  • the inner diameter of the center lumen 11 is configured to be larger than the inner diameter of the second support wire lumens 18a to 18c.
  • the inner diameter of the second support wire lumens 18a-18c may be the same as or different from the inner diameter of the first support wire lumens 13a-13c.
  • the puncture catheter ports 12a to 12c and the second support wire ports 19a to 19c are arranged at opposing positions with respect to the axis X of the tube 102.
  • the puncture catheter ports 12a to 12c and the second support wire ports It is intended that the support wire ports 19a to 19c may be disposed at positions generally facing each other with respect to the axis X, and the puncture catheter ports 12a to 12c and the second support wire ports 19a to 19c are not necessarily It is not intended that the two be placed at positions directly opposite to the axis X.
  • the opening centers 19d of the second support wire ports 19a to 19c may be located in a range where the angle ⁇ defined by the virtual straight line L and the axis X satisfies -45° ⁇ 45°. Further, as shown in FIG. 7A, regarding the first support wire ports 14a to 14c and the second support wire ports 19a to 19c located at the closest positions in the axis X direction, the opening center 14d of the first support wire ports 14a to 14c The midpoint Rc of the imaginary straight line connecting the opening centers 19d of the second support wire ports 19a to 19c is located at a position opposite to the puncture catheter ports 12a to 12c with respect to the axis X of the tube 102. Good too.
  • the midpoint Rc may be located in a range where the angle ⁇ defined by the virtual straight line L and the axis X satisfies -45° ⁇ 45°.
  • FIG. 6B is a diagram showing an example of when the puncture catheter Cp and the support wire Ws are inserted into the tube 102 of FIG. 6A.
  • FIG. 7B is a vertical projection view of the tube 102 of FIG. 6B in the axis X direction.
  • the puncture catheter Cp of the puncture catheter ports 12a to 12c is The support wire Ws is sent out from each of the support wires Ws, and the support wire Ws is brought into contact with the inner wall of the blood vessel BV, thereby identifying the treatment area. Due to the repulsive force when the puncture needle of the puncture catheter Cp punctures the body tissue of the blood vessel BV, it is possible to suppress the liquid drug injection unit 200 from moving in the direction away from the blood vessel BV.
  • Two or more of the at least three second support wire ports 19a to 19c may be selected as the second support wire ports 19a to 19c through which the support wire Ws is sent out. That is, by sending out the support wire Ws from each of two or more of the at least three second support wire ports 19a to 19c, the liquid drug injection unit 200 may be prevented from moving away from the blood vessel BV. . Furthermore, by sending out two or more support wires Ws from one of the at least three second support wire ports 19a to 19c, the liquid drug injection unit 200 may be prevented from moving away from the blood vessel BV. good.
  • FIG. 8 is a transparent perspective view schematically showing a part of the tube 103 included in the chemical liquid injection unit 300 of Modification 3.
  • the liquid drug injection unit 300 of Modification 3 includes a plurality of puncture catheter sets Sp (Sp1, Sp2) each including at least three puncture catheter ports 12a to 12c, and the plurality of puncture catheter sets Sp are arranged in different longitudinal directions of the tube 103. It has the same configuration as the chemical liquid injection unit 1 including the tube 10 except that it is arranged at the same position.
  • the liquid drug injection unit 300 includes a plurality of puncture catheter sets Sp (Sp1, Sp2) arranged at different positions in the longitudinal direction of the tube 103. Therefore, the number of options for the puncture catheter ports 12a to 12c through which the puncture catheter Cp is delivered increases, so that the drug solution can be delivered to multiple locations in a specific body tissue, which is the treatment site, without moving the drug solution injection unit 300 back and forth within the blood vessel BV. Can be easily injected.
  • a set including at least three support wire ports 14a to 14c is defined as a support set Ss.
  • a support set Ss may be disposed between the puncture catheter set Sp1 and the puncture catheter set Sp2 in the axis X direction. According to such a configuration, whether the puncture wire ports 12a to 12c of the puncture catheter set Sp1 on the distal side are used or the puncture wire ports 12a to 12c of the puncture wire set Sp2 on the proximal end are used. Also, the support set Ss can prevent the drug solution injection unit 300 from moving away from the blood vessel BV.
  • the drug solution injection unit 300 may include a plurality of support sets Ss.
  • the puncture catheter set Sp, the support set Ss, the puncture catheter set Sp, the support set Ss, etc. may be arranged in this order from the distal end side to the proximal end side.
  • each of the support wire ports 14a to 14c of the plurality of support sets Ss may communicate with a common support wire lumen 13a to 13c, respectively.
  • the aspect of Modification 2 can also be applied to the chemical liquid injection unit 300 of Modification 3. That is, in addition to the first support set Ss1 including at least three first support wire ports 14a to 14c, the drug solution injection unit 300 includes a second support set Ss2 including at least three second support wire ports 19a to 19c. You may be prepared.
  • the drug solution injection unit 300 may include a plurality of second support sets Ss2.
  • FIG. 9 is a schematic explanatory diagram showing the structure of a liquid medicine injection unit 400 according to modification 4.
  • the support mechanism 40 includes a balloon member 50 having a balloon 51. That is, the drug solution injection unit 400 of Modification 4 is different from the drug solution injection unit 1 except that the puncture catheter ports 12a to 12c and the balloon member 50 are arranged at opposing positions with respect to the axis X of the tube 10. have the same configuration.
  • FIG. 10 is a transparent perspective view schematically showing a part of the tube 10 and balloon member 50 included in the drug solution injection unit 400.
  • FIG. 10 roughly corresponds to the part indicated by the symbol A' in FIG.
  • the balloon member 50 further includes a long tube 52 and a distal tip 53 attached to the distal end side of the tube 52.
  • a balloon 51 is provided between the distal tip 53 and the tube 52.
  • the balloon member 50 may be integrated with the tube 10 on the proximal end side, or may be separate from the tube 10.
  • the balloon member 50 may further include a connector (not shown) connected to the proximal end of the tube 52.
  • the balloon member 50 can supply fluid to the internal space of the balloon 51 via the tube 52. This causes the balloon 5 to expand.
  • FIG. 11 is a diagram showing a vertical projection view of the tube 10 in FIG. 9 along with the balloon member 50 in the axis X direction.
  • the puncture catheter ports 12a to 12c and the balloon member 50 are arranged at opposing positions with respect to the axis X of the tube 10.
  • the puncture catheter ports 12a to 12c and the balloon member 50 are arranged at positions facing each other with respect to the axis X of the tube 10" means that the puncture catheter ports 12a to 12c and the balloon member 50 It is intended that the puncture catheter ports 12a to 12c and the balloon member 50 may be placed in positions that are generally facing each other with respect to the axis It is not intended that they be placed in opposing positions.
  • the center 50a of the balloon member 50 may be located within a range where the angle ⁇ defined by the virtual straight line L and the axis X satisfies -45° ⁇ 45°.
  • the support mechanism 40 since the support mechanism 40 includes the balloon member 50 having the balloon 51, the drug solution injection unit 400 is separated from the blood vessel BV due to the repulsive force when puncturing a specific body tissue that is a treatment site with the puncture needle. Movement in this direction can be suppressed.
  • Two or more balloon members 50 may be used as the balloon member 50. That is, two or more balloons 51 may function as the support mechanism 40. In this case, the stability of the chemical liquid injection unit 400 is further improved.
  • FIG. 11 shows an example in which three balloon members 50 are used as the balloon members 50. In FIG.
  • the center lumen 11, support wire lumens (first support wire lumens) 13a to 13c, second support wire lumens 18a to 18c, and guide wire lumen 16 described above are tube bodies made of resin.
  • the resin material forming the tube bodies of these lumens is not particularly limited, but resins that have good sliding properties with other members are preferred, such as PTFE (polytetrafluoroethylene), PVDF (polyvinylidene fluoride), Examples include fluororesins such as PFA (perfluoroalkoxyalkane), FEP (perfluoroethylene propene), and ETFE (ethylene tetrafluoroethylene), PE (polyethylene), and PP (polypropylene).
  • the tube bodies constituting the center lumen 11, the support wire lumens (first support wire lumens) 13a to 13c, the second support wire lumens 18a to 18c, and the guide wire lumen 16 are made of the same resin material. Alternatively, they may be made of different resin materials.
  • a reinforcing body may be arranged around the outer periphery of the tube body.
  • the reinforcing body is, for example, a braided body (metal braid layer) formed by weaving a plurality of wires into a mesh shape.
  • the reinforcing body may cover the entire outer periphery of the tube body, or may cover a part of the outer periphery of the tube body.
  • a resin outer layer tube (not shown) in which the reinforcing body is embedded may be arranged around the outer periphery of the tube body.
  • the tubes 10, 101, 102, and 103 are made of resin.
  • the tube 10 covers the tube body forming the center lumen 11 and the tube bodies forming the support wire lumens (first support wire lumens) 13a to 13c.
  • the resin material forming the tubes 10, 101, 102, and 103 is not particularly limited, but examples include polyamide, polyamide elastomer, polyester, polyurethane, and polyurethane elastomer.
  • the tubes 10, 101, 102, and 103 may be formed of a single resin material, or may be divided into a plurality of regions and formed using a plurality of resin materials each having different characteristics.
  • the resin forming the tubes 10, 101, 102, and 103 may contain tungsten powder, and the hardness of the resin may be changed depending on the content.
  • tungsten powder which is an X-ray opaque powder
  • a medical technician such as a doctor can accurately grasp the position of the liquid drug injection unit 1 during treatment. be able to.
  • the present invention is not limited to the above embodiments, and various modifications can be made.
  • the drug solution injection unit was described as a catheter used to inject a drug solution into a specific body tissue that is a treatment site, but the catheter to which the drug solution injection unit of the present invention is applied is
  • the present invention is not limited to injection use, and may be applied to endoscopes, etc., for example.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
PCT/JP2023/019863 2022-06-24 2023-05-29 薬液注入ユニット Ceased WO2023248722A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US18/985,494 US20250114573A1 (en) 2022-06-24 2024-12-18 Chemical liquid injection unit

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2022-101967 2022-06-24
JP2022101967A JP7811520B2 (ja) 2022-06-24 2022-06-24 薬液注入ユニット

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US18/985,494 Continuation US20250114573A1 (en) 2022-06-24 2024-12-18 Chemical liquid injection unit

Publications (1)

Publication Number Publication Date
WO2023248722A1 true WO2023248722A1 (ja) 2023-12-28

Family

ID=89379753

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2023/019863 Ceased WO2023248722A1 (ja) 2022-06-24 2023-05-29 薬液注入ユニット

Country Status (3)

Country Link
US (1) US20250114573A1 (https=)
JP (1) JP7811520B2 (https=)
WO (1) WO2023248722A1 (https=)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5464395A (en) * 1994-04-05 1995-11-07 Faxon; David P. Catheter for delivering therapeutic and/or diagnostic agents to the tissue surrounding a bodily passageway
JP2000014663A (ja) * 1998-06-30 2000-01-18 Olympus Optical Co Ltd 前立腺肥大治療用装置
JP2001299927A (ja) * 2000-04-27 2001-10-30 Kawasumi Lab Inc 脈管用薬液注入カテーテル
JP2004267333A (ja) * 2003-03-06 2004-09-30 Osamu Kato 薬液注入装置
JP2011505918A (ja) * 2007-12-06 2011-03-03 アボット、カーディオバスキュラー、システムズ、インコーポレーテッド 半径方向に拡張可能なセンタリング支持部材を有する薬剤送達カテーテル

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5464395A (en) * 1994-04-05 1995-11-07 Faxon; David P. Catheter for delivering therapeutic and/or diagnostic agents to the tissue surrounding a bodily passageway
JP2000014663A (ja) * 1998-06-30 2000-01-18 Olympus Optical Co Ltd 前立腺肥大治療用装置
JP2001299927A (ja) * 2000-04-27 2001-10-30 Kawasumi Lab Inc 脈管用薬液注入カテーテル
JP2004267333A (ja) * 2003-03-06 2004-09-30 Osamu Kato 薬液注入装置
JP2011505918A (ja) * 2007-12-06 2011-03-03 アボット、カーディオバスキュラー、システムズ、インコーポレーテッド 半径方向に拡張可能なセンタリング支持部材を有する薬剤送達カテーテル

Also Published As

Publication number Publication date
JP7811520B2 (ja) 2026-02-05
JP2024002640A (ja) 2024-01-11
US20250114573A1 (en) 2025-04-10

Similar Documents

Publication Publication Date Title
US9498602B2 (en) Guided intravascular catheter sheath having bi-directional steering assembly
US9907570B2 (en) Steerable medical devices
US10029073B2 (en) Steerable assembly for surgical catheter
US12589219B2 (en) Steerable sheath with variable curve span
US8608727B2 (en) Delivery system and method
US20070276324A1 (en) Tri-directional articulating catheter
US20070100235A1 (en) Steerable catheter devices and methods of articulating catheter devices
US9821143B2 (en) Steerable sheath including elastomeric member
CN218961553U (zh) 一种可调弯鞘管组件
CN219398622U (zh) 一种增强复合型鞘管
US20250249205A1 (en) Catheter
EP4147739B1 (en) Catheter
JP2019187771A (ja) カテーテル組立体
JP7811520B2 (ja) 薬液注入ユニット
JP6453676B2 (ja) カテーテル組立体
JP2017000442A (ja) カテーテル
WO2025070057A1 (ja) 医療デバイス
CN116570350B (zh) 一种可调弯鞘管组件
WO2023095694A1 (ja) カテーテル
US20230398284A1 (en) Devices, systems, and methods for delivering fluid through a tubular element
WO2023095838A1 (ja) カテーテル
WO2024238801A1 (en) Pigtail dilator system
JP2018157913A (ja) 医療用デバイス
WO2024150193A1 (en) Balloon catheter for selective side vessel infusion
WO2024053201A1 (ja) カテーテル

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 23826910

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 23826910

Country of ref document: EP

Kind code of ref document: A1