WO2023207208A1

WO2023207208A1 - Sample analyzer and pressure buildup control method therefor

Info

Publication number: WO2023207208A1
Application number: PCT/CN2022/144435
Authority: WO
Inventors: 池书锐; 褚聪; 甘小锋
Original assignee: 深圳市帝迈生物技术有限公司
Priority date: 2022-04-24
Filing date: 2022-12-31
Publication date: 2023-11-02
Also published as: CN114527055A; CN114527055B

Abstract

A sample analyzer and a pressure buildup control method. The sample analyzer comprises a gas storage apparatus (101), a pressure source (102) and a counting cell (103), which are connected to the gas storage apparatus (101), a pressure buildup path, which is connected between the gas storage apparatus (101) and the pressure source (102), a pressure measurement element (106), which is connected to the gas storage apparatus (101), and a control device (107), wherein the control device (107) is connected to the pressure buildup path and the pressure measurement element (106); when the counting cell (103) is in a preset state, the control device (107) controls the pressure buildup path to open, and the pressure source (102) performs pressure buildup on the gas storage apparatus (101); and when the current pressure value in the gas storage apparatus (101) reaches a first preset pressure value, the control device (107) controls the pressure buildup path to close, and controls the current pressure value of the gas storage apparatus (101) to be adjusted to a second preset pressure value within a first preset time range, wherein the absolute value of the first preset pressure value is greater than the absolute value of the second preset pressure value.

Description

Sample analyzer and pressure building control method

Cross-references to related applications

This application claims priority to Chinese patent application 2022104347947 titled "Sample Analyzer and Its Liquid Circuit System and Pressure Building Control Method" submitted on April 24, 2022. The entire content of this application is incorporated into this article by reference. .

Technical field

The present application relates to the field of medical detection technology, specifically to a sample analyzer and a pressure-building control method applied to the sample analyzer.

Background technique

With the promotion of the application of blood cell analyzers, the requirements for the accuracy and precision of blood cell analyzer test results are becoming higher and higher. Electrical impedance method is the mainstream methodology for detecting and counting blood cells. It mainly counts and sorts blood cells by counting the changes in electrical signals caused by the cells in the sample liquid passing through the small holes. Its power source is the negative pressure established by the internal pump of the instrument.

The current common pressure building method is relatively extensive. As shown in Figure 1, the gas storage device 101 is directly connected to the pressure source 102. The gas storage device 101 is a gas tank, and the pressure source 103 is a gas pump. Generally, one pump is connected to one gas tank. The gas pump is turned on to build pressure. When the pressure reaches a certain range, the gas pump is turned off. There are two problems with this pressure building method: (1) the air pump builds pressure too quickly and the pressure overshoots, resulting in inaccurate pressure building or false alarms; (2) short-term pressure changes in the gas tank, the internal pressure of the gas tank is unbalanced, and the air pump After closing, the pressure will undergo a rebalancing process, resulting in inaccurate pressure build-up.

technical problem

(1) The air pump builds pressure too quickly and the pressure overshoots, resulting in inaccurate pressure build-up or false alarms; (2) The pressure in the air tank changes in a short period of time, and the pressure inside the air tank is unbalanced. After the air pump is closed, the pressure will be rebalanced. process, resulting in inaccurate pressure building.

Technical solutions

In view of this, in order to solve the above technical problems, the present application provides a sample analyzer that can accurately reach the target pressure value during the pressure building process, and a pressure building control method applied to the sample analyzer.

In order to achieve the above object, the technical solution of the embodiment of the present application is implemented as follows:

A sample analyzer, including a gas storage device, a pressure source and a counting cell connected to the gas storage device, a pressure-building passage connected between the gas storage device and the pressure source, and the gas storage device The connected pressure detection element and control equipment; the control equipment is connected with the negative pressure passage and the pressure detection element; wherein the pressure detection element is used to detect the current pressure value in the gas storage device; When the counting pool is in a preset state, the control device controls the opening of the pressure-building passage and the closing of the pressure-relief passage, and the pressure source builds pressure on the gas storage device; when the current pressure in the gas storage device When the value reaches the first preset pressure value, the control device controls the pressure building passage to close, and controls the current pressure value of the gas storage device to adjust to the second preset pressure value within the first preset time range; Wherein, the absolute value of the first preset pressure value is greater than the absolute value of the second preset pressure value.

Optionally, the sample analyzer further includes a pressure relief passage and a timer, and the pressure relief passage and the timer are connected to the control device; when the current pressure value in the gas storage device reaches the third At a preset pressure value, the control device controls the pressure-building passage to close, and controlling the current pressure value of the gas storage device to adjust to the second preset pressure value within the first preset time range includes: when the When the current pressure value in the gas storage device reaches the first preset pressure value, the control device controls the pressure building passage to close, and controls to start the timer to start timing, and determines that the reading of the timer reaches the preset pressure value. When the time is set, the pressure relief passage is controlled to be opened; the gas storage device relieves pressure through the pressure relief passage, and when the current pressure value in the gas storage device reaches the second preset pressure value, the The control device controls the closure of the pressure relief passage.

Optionally, the pressure-building passage includes a negative pressure passage, and the control device is connected to the negative pressure passage and the pressure detection element; when the counting pool is turned on for counting, the control device controls the negative pressure passage. When the pressure relief passage is opened and the pressure relief passage is closed, the pressure source establishes a negative pressure on the gas storage device; when the current pressure value in the gas storage device reaches the first preset pressure value, the control device controls the The negative pressure passage is closed, and the timer is controlled to start timing. When it is determined that the reading of the timer reaches the first preset time period, the pressure relief passage is controlled to be opened; the gas storage device is operated through the pressure relief passage. For pressure relief, when the current pressure value in the gas storage device reaches the second preset pressure value, the control device controls the pressure relief passage to close, and the counting pool performs a counting process.

Optionally, the pressure building passage includes a positive pressure passage, and the control device is connected to the positive pressure passage and the pressure detection element; when the counting tank stops counting, the control device controls the positive pressure passage. When the negative pressure passage and the pressure relief passage are opened, the pressure source establishes positive pressure on the gas storage device; when the current pressure value in the gas storage device reaches the first preset pressure value, the The control device controls the closure of the positive pressure passage and controls the start of the timer to start timing. When it is determined that the reading of the timer reaches the second preset length of time, it controls the opening of the pressure relief passage; the gas storage device passes through the The pressure relief passage performs pressure relief. When the current pressure value in the gas storage device reaches a second preset pressure value, the control device controls the pressure relief passage to close, and the gas storage device performs waste discharge. liquid process.

Optionally, the positive pressure passage includes a third control valve, the third control valve is connected to the control device, and the control device is used to control the third control valve when the pressure source applies pressure to the storage tank. When the gas device establishes positive pressure, the passage between the pressure source and the gas storage device is connected or cut off.

Optionally, the negative pressure passage includes a first control valve, the first control valve is connected to the control device, and the control device is used to control the first control valve when the pressure source applies pressure to the storage tank. When the gas device establishes negative pressure, the passage between the pressure source and the gas storage device is connected or cut off.

Optionally, the sample analyzer further includes a first liquid pumping passage connected between the counting cell and the gas storage device. During the counting process of the counting cell, the control device controls the The first liquid pumping passage is opened, and the gas storage device draws the sample liquid to be measured in the counting pool into the gas storage device through the current pressure inside the gas storage device and the first liquid pumping passage. The level signal generated when the cells in the sample liquid to be tested are filtered determines the count value of the cells in the sample liquid to be tested.

Optionally, the first liquid pumping passage includes a fourth control valve, the fourth control valve is connected to the control device, and the control device is used to control the fourth control valve when the gas storage device is When the counting tank provides pressure, the passage between the gas storage device and the counting tank is connected or cut off.

Optionally, the sample analyzer further includes a second liquid pumping passage connected between the counting cell and the gas storage device. When the counting cell completes the counting process, the control device controls the second The liquid pumping passage is opened, and the gas storage device pumps the remaining sample liquid to be measured in the counting cell into the gas storage device through the second liquid pumping passage.

Optionally, the second liquid pumping passage includes a fifth control valve, the fifth control valve is connected to the control device, and the control device is used to control the fifth control valve to connect or cut off the gas storage. The passage between the device and the counting cell.

Optionally, the counting pool includes an impedance detection counting pool, and the impedance detection counting pool includes a front pool, a rear pool, and a cell filter assembly located between the front pool and the rear pool, and the front pool is used to hold cells. The sample liquid to be detected is placed, and the gas storage device is used to drive the sample liquid to be detected in the front tank to flow to the rear tank under pressure.

Optionally, the counting cell includes an optical detection counting cell, the optical detection counting cell includes a flow chamber, and the gas storage device is used to drive the sheath liquid to flow in the flow chamber under pressure.

Optionally, the sample analyzer further includes multiple liquid adding channels connected between the counting tank and the diluent. When the counting tank completes the counting process, the control device controls the multiple liquid adding channels. It is turned on at the same time, and the diluent is poured into the counting tank through the plurality of liquid adding channels.

Optionally, the liquid adding passage includes a sixth control valve, the sixth control valve is connected to the control device, and the control device is used to control the sixth control valve to communicate or cut off the diluent from the diluent. The path between the counting pools.

Optionally, the sample analyzer further includes a flow restricting member, which is connected to the gas storage device through the pressure relief passage; the flow restricting member is used to adjust the pressure relief of the gas storage device. flow.

Optionally, the embodiment of the present application also provides a pressure-building control method including the sample analyzer described in any of the above embodiments, applied to the control device, including: controlling the pressure-building according to the received trigger signal. The passage is opened; the current pressure value in the gas storage device detected by the pressure detection element is received, and when the current pressure value in the gas storage device is obtained and reaches the first preset pressure value, the pressure build-up is controlled. The passage is closed, and the current pressure value of the gas storage device is controlled to be adjusted to a second preset pressure value within a first preset time range; wherein the absolute value of the first preset pressure value is greater than the second preset pressure value. Absolute value.

Optionally, the pressure building path includes a negative pressure path, the sample analyzer also includes a pressure relief path and a timer, and the control device is connected to the negative pressure path, the pressure relief path, the timer and The pressure detection element is connected; when the counting pool is opened for counting, the control device controls the opening of the negative pressure passage and the closing of the pressure relief passage, so that the pressure source establishes negative pressure on the gas storage device; When it is obtained that the current pressure value in the gas storage device reaches the first preset pressure value, the pressure building passage is controlled to close, and the current pressure value of the gas storage device is controlled to be adjusted within the first preset time range. To the second preset pressure value includes: when the current pressure value in the gas storage device is obtained to reach the first preset pressure value, controlling the negative pressure passage to close, and controlling the start timer to start timing, and determining the timer When the reading reaches the first preset time period, the pressure relief passage is controlled to open; when the current pressure value in the gas storage device reaches the second preset pressure value, the control device controls the pressure relief passage closure.

Optionally, the pressure building path includes a positive pressure path, the sample analyzer also includes a pressure relief path and a timer, and the control device is connected to the positive pressure path, the pressure relief path, the timer and The pressure detection element is connected; when the counting pool stops counting, the control device controls the positive pressure passage to open and the pressure relief passage to close, so that the pressure source establishes positive pressure on the gas storage device; When it is obtained that the current pressure value in the gas storage device reaches the first preset pressure value, the pressure building passage is controlled to close, and the current pressure value of the gas storage device is controlled to be adjusted within the first preset time range. To the second preset pressure value includes: when the current pressure value in the gas storage device reaches the first preset pressure value, controlling the positive pressure passage to close, and controlling the timer to start timing, and determining the timer When the reading reaches the second preset time period, the pressure relief passage is controlled to open; when the current pressure value in the gas storage device reaches the second preset pressure value, the control device controls the pressure relief passage to close .

beneficial effects

In the sample analyzer provided in the above embodiments of the present application, when the counting cell is in a preset state, the control device controls the pressure-building passage to open, and the pressure source builds pressure on the gas storage device; when the When the current pressure value in the gas storage device reaches the first preset pressure value, the control device controls the pressure regulating passage to close, and controls the current pressure value of the gas storage device to adjust to Second preset pressure value. In this way, the sample analyzer can allow the air pressure in the gas storage device to have a certain period of time to rebalance after rapid pressure build-up, so that the air pressure in the gas storage device can reach the second preset pressure value more stably and accurately, effectively. This avoids the situation where the air pressure in the gas storage device is inaccurate due to pressure rebalancing after the pressure source is closed.

Among them, the pressure-building control method, sample analyzer, computer equipment and computer-readable storage medium used in the sample analyzer contain the same specific technical features as the liquid circuit system, and have the same benefits as the sample analyzer. The technical effects will not be repeated here.

Description of drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the embodiments or description of the prior art will be briefly introduced below. Obviously, the drawings in the following description are only for the purpose of the present application. For some embodiments, for those of ordinary skill in the art, other drawings can be obtained based on these drawings without exerting creative efforts.

Figure 1 is a schematic diagram of the connection between the pressure source and the gas storage device in the prior art;

Figure 2 is a schematic structural diagram of a sample analyzer in an embodiment of the present application;

Figure 3 is a circuit connection diagram of each device in the sample analyzer provided by an embodiment of the present application;

Figure 4 is a flow chart of a pressure building control method applied to control equipment in a sample analyzer provided by an embodiment of the present application;

Figure 5 is a graph of the pressure change in the gas storage device when the control device controls the pressure source to establish negative pressure in the gas storage device in the prior art;

Figure 6 is a graph of the pressure change in the gas storage device after the control device controls the pressure source to establish negative pressure in the gas storage device in the embodiment of the present application;

Figure 7 is a graph of the pressure change in the gas storage device when the control pressure source of the control equipment in the embodiment of the present application is to establish a positive pressure in the gas storage device;

Figure 8 is a specific flow chart for controlling the work of each device in the sample analyzer described in one embodiment of the present application;

[Correction under Rule 91 27.02.2023]

Detailed ways

In order to enable those skilled in the art to better understand the technical solutions of the present application, the present application will be described in further detail below in conjunction with the accompanying drawings and specific embodiments. Obviously, the described embodiments are only some of the embodiments of the present application, but not all of the embodiments. Based on the embodiments in this application, all other embodiments obtained by those of ordinary skill in the art without creative efforts fall within the scope of protection of this application.

The technical solution of the present application will be further described in detail below with reference to the accompanying drawings and specific embodiments of the description.

Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the technical field to which this application belongs. The terms used herein in the description of the present application are only for the purpose of describing specific embodiments and are not intended to limit the implementation of the present application. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.

In the description of this application, it should be understood that the terms "center", "upper", "lower", "front", "back", "left", "right", "vertical", "horizontal", The orientations or positional relationships indicated by "top", "bottom", "inner", "outside", etc. are based on the orientations or positional relationships shown in the drawings. They are only for the convenience of describing the present application and simplifying the description, and are not indicated or implied. The devices or elements referred to must have a specific orientation, be constructed and operate in a specific orientation, and therefore should not be construed as limiting the application. In the description of this application, unless otherwise stated, "plurality" means two or more.

In the description of this application, it should be noted that, unless otherwise clearly specified and limited, the terms "installation", "connection" and "connection" should be understood in a broad sense. For example, it can be a fixed connection or a fixed connection. It is a detachable connection or an integral connection; it can be directly connected or indirectly connected through an intermediary, or it can be an internal connection between two components. For those of ordinary skill in the art, the specific meanings of the above terms in this application can be understood according to specific circumstances.

Please refer to Figures 2 and 3. Figure 2 is a schematic structural diagram of a sample analyzer provided by an embodiment of the present application. Figure 3 is a circuit connection diagram of each device in the sample analyzer provided by an embodiment of the present application. The sample analyzer includes a gas storage device 101, a pressure source 102 and a counting cell 103 connected to the gas storage device 101, a pressure building passage connected between the gas storage device 101 and the pressure source 102, and The pressure detection element 106 and the control device 107 are connected to the gas storage device 101; the control device 107 is connected to the pressure building passage and the pressure detection element 106; when the counting tank 103 is in a preset state, the The control device 107 controls the opening of the pressure-building passage, and the pressure source 102 builds pressure on the gas storage device 101; when the current pressure value in the gas storage device 101 reaches the first preset pressure value, the control device 107 The device 107 controls the closing of the pressure-building passage, and controls the current pressure value of the gas storage device 101 to be adjusted to a second preset pressure value within a first preset time range; wherein, the absolute value of the first preset pressure value greater than the absolute value of the second preset pressure value.

Here, the gas storage device 101 is used to provide a pressure-building place, which may be a gas storage tank or the like. The pressure source 102 is used to establish negative pressure or positive pressure in the gas storage device 101, and may be an air pump or the like. The pressure-building passage may include a negative pressure passage 104 and a positive pressure passage 105. The negative pressure passage 104 is used by the pressure source 102 to establish negative pressure for the gas storage device 101, and the positive pressure passage 105 is used by the pressure source 102 for the gas storage device 101. The gas device 101 establishes positive pressure. In some embodiments, the counting pool 103 may be an impedance detection counting pool. The counting tank 103 is used to provide a cell counting place for the sample liquid to be detected, and includes a front tank, a back tank, and a cell filtering component located between the front tank and the back tank. The front tank is used to hold the sample liquid to be detected, and the gas storage device 101 is used to drive the sample liquid to be detected in the front tank to flow to the rear tank under the action of pressure. The sample liquid to be detected is under the negative pressure of the gas storage device 101. It flows down to the rear pool through the filter component, where when each cell in the sample liquid to be detected passes through the small hole of the filter component, a corresponding level signal will be generated, and the counter 103 will record the changes in the level signal. It is sent to the control device 107 to realize the counting of cells in the sample liquid to be tested. The negative pressure in the gas storage device 101 is mainly used to drive the sample liquid to be detected in the counting tank 103 to flow from the front tank through the filter assembly to the rear tank. The positive pressure in the gas storage device 101 is mainly used by the gas storage device 103 to perform the waste liquid discharge process. The control device 107 may be a programmable controller, such as a PLC controller, a microcontroller controller, a computer host CPU controller, etc. The pressure detection element 106 may be a pressure detector or a pressure sensor. The first preset pressure value may refer to the initial pressure value when the pressure source 102 builds pressure on the gas storage device 101 . The second preset pressure value may refer to a target pressure value for building pressure in the gas storage device 101 . In this embodiment of the present application, the absolute value of the first preset pressure value is higher than the absolute value of the second preset pressure value. In the embodiment of the present application, when the counting pool 103 is in a preset state, the control device 107 controls the pressure-building passage to open, and the pressure source 102 builds pressure on the gas storage device 101; when the current pressure value in the gas storage device 101 reaches the first When the pressure value is preset, the control device 107 controls the pressure regulating passage to close, and controls the current pressure value of the gas storage device 101 to adjust to the second preset pressure value within the first preset time range. In this way, the sample analyzer can allow the air pressure in the gas storage device 101 to have a certain period of time to rebalance after rapid pressure build-up, so that the air pressure in the gas storage device can reach the target pressure value more stably and accurately, effectively avoiding The air pressure in the gas storage device is inaccurate due to pressure rebalancing after the pressure source is shut down.

In some embodiments, the pressure building path includes a negative pressure path 104, the sample analyzer also includes a pressure relief path 105 and a timer 112, and the control device 107 is connected to the negative pressure path 104, the pressure relief path 104, and the pressure relief path 104. The passage 105, the timer 112 and the pressure detection element 106 are connected; when the counting tank 112 is turned on for counting, the control device 107 controls the negative pressure passage 104 to open and the pressure relief passage 105 to close. The pressure source 102 establishes negative pressure on the gas storage device 101; when the current pressure value in the gas storage device 101 reaches the first preset pressure value, the control device 107 controls the negative pressure passage 104 to close, and The timer 112 is controlled to start timing, and when it is determined that the reading of the timer 112 reaches the first preset time period, the pressure relief passage 105 is controlled to open; the gas storage device 101 is vented through the pressure relief passage 105 When the current pressure value in the gas storage device 101 reaches the second preset pressure value, the control device 107 controls the pressure relief passage 105 to close, and the counting pool 103 executes a counting process.

Here, the negative pressure passage 104 includes a first control valve 1041 , and the first control valve 1041 is connected to the control device 107 . The control device 107 controls the first control valve 1041 to connect or cut off the passage between the pressure source 102 and the gas storage device 101 when the pressure source 102 establishes negative pressure on the gas storage device 101 . The pressure relief passage 105 includes a second control valve 1051 , and the second control valve 1051 is connected to the control device 107 . The control device 107 controls the second control valve 1051 to connect or cut off the passage between the gas storage device 101 and the atmosphere when depressurizing the gas storage device 101 . The negative pressure in the gas storage device 101 is mainly used to provide a stable negative pressure for the counting cell 103 . The timer 112 is used to record the stopping time after the current pressure value in the gas storage device 101 reaches the first preset pressure value. The first preset duration may be a pause duration preset in the control device 107 for controlling the gas storage device 101 after the negative pressure is established, such as 0.5S. Here, the first preset pressure value may refer to the initial pressure value when the pressure source 102 establishes negative pressure on the gas storage device 101 . The second preset pressure value may refer to a target pressure value for establishing negative pressure on the gas storage device 101 .

In the embodiment of the present application, when the negative pressure in the gas storage device 101 reaches the first preset value, by setting a pause time of the first preset length, it can be ensured that the negative pressure in the gas storage device 101 has enough time to reset. Balance effectively solves the problem in the prior art that the built-in pressure of the gas storage device 101 is inaccurate due to the pressure source 102 being pressurized too quickly, so that the air pressure in the gas storage device 101 can reach the target pressure value more stably and accurately. . Furthermore, when the counting pool 103 performs the counting process, the gas storage device 101 can provide it with a negative pressure with higher accuracy and better stability.

In some embodiments, the pressure-building path includes a positive pressure path 108, and the sample analyzer also includes a pressure relief path 105 and a timer 112. The control device 107 is connected to the positive pressure path 108, the pressure relief path 108, and the pressure relief path 108. The passage 105, the timer 112 and the pressure detection element 106 are connected; when the counting tank 103 stops counting, the control device 107 controls the positive pressure passage 108 to open and the pressure relief passage 105 to close. The pressure source 102 establishes positive pressure on the gas storage device 101; when the current pressure value in the gas storage device 101 reaches the first preset pressure value, the control device 107 controls the positive pressure passage 108 to close and control Start the timer 112 to start timing, and when it is determined that the reading of the timer 112 reaches the second preset time period, the pressure relief passage 105 is controlled to open; the gas storage device 101 performs pressure relief through the pressure relief passage 105 , when the current pressure value in the gas storage device 101 reaches the second preset pressure value, the control device 107 controls the pressure relief passage 105 to close, and the gas storage device 101 executes a waste liquid discharge process.

Here, the positive pressure passage 108 includes a third control valve 1081 , and the third control valve 1081 is connected to the control device 107 . The control device 107 controls the third control valve 1081 to connect or cut off the passage between the pressure source 102 and the gas storage device 101 when the pressure source 102 establishes positive pressure on the gas storage device 101 . The positive pressure is mainly used to discharge the waste liquid stored in the gas storage device 101 . Here, the first preset pressure value may refer to the initial pressure value when the pressure source 102 establishes positive pressure on the gas storage device 101 . The second preset pressure value may refer to a target pressure value for establishing a positive pressure on the gas storage device 101 . The stop of counting by the counting cell 103 may mean that the counting cell 103 has completed counting cells in the sample liquid to be detected. The second preset duration may be a pause duration preset in the control device 107 for controlling the gas storage device 101 after establishing positive pressure.

In the embodiment of the present application, when the positive pressure in the gas storage device 101 reaches the first preset value, by setting a pause time of a second preset length, it can be ensured that the positive pressure in the gas storage device 101 has enough time to reset. Balance effectively solves the problem in the prior art that the built-in pressure of the gas storage device 101 is inaccurate due to the pressure source 102 being pressurized too quickly, so that the air pressure in the gas storage device 101 can reach the target pressure value more stably and accurately. . Furthermore, when the gas storage device 101 executes the waste liquid discharge process, it can effectively ensure that the waste liquid in the gas storage device is completely discharged at one time.

In some other embodiments, the counting cell 103 may be an optical detection counting cell. The optical detection and counting cell includes a flow chamber, and the gas storage device 101 is used to drive the sheath liquid to flow in the flow chamber under pressure. For example, by establishing a positive pressure in the gas storage device 101, under the positive pressure provided by the gas storage device 101 , push the sheath liquid into the flow chamber of the optical detection and counting cell, and the sample liquid to be tested entering the flow chamber is detected and counted in the optical detection and counting cell by the optical detection method, driven by the sheath liquid. The pressure building path includes a positive pressure path, the sample analyzer also includes a pressure relief path and a timer, the control device is connected to the positive pressure path, the pressure relief path, the timer and the pressure detection The components are connected; when the counting pool is opened for counting, the control device controls the opening of the positive pressure passage and the closing of the pressure relief passage, and the pressure source establishes positive pressure on the gas storage device; when the gas storage device When the current pressure value within reaches the first preset pressure value, the control device controls the positive pressure passage to close and starts the timer to start timing, and determines that when the timer reading reaches the third preset time length, Control the opening of the pressure relief passage; the gas storage device performs pressure relief through the pressure relief passage. When the current pressure value in the gas storage device reaches a second preset pressure value, the control device controls The pressure relief passage is closed, and the counting pool executes the counting process.

In some embodiments, the sample analyzer further includes a first liquid pumping passage 109 connected between the counting cell 103 and the gas storage device 101. During the counting process of the counting cell 103, The control device 107 controls the opening of the first liquid pumping passage 109, and the gas storage device 101 draws the sample liquid to be measured in the counting tank 103 to the desired location through the current pressure in the gas storage device 101 and the first liquid pumping passage 109. In the gas storage device 101, the control device 107 determines the count value of cells in the sample liquid to be tested based on the level signal generated when the cells in the sample liquid to be tested are filtered.

Here, the first liquid pumping passage 109 includes a fourth control valve 1091 , and the fourth control valve 1091 is connected to the control device 107 . The control device 107 controls the fourth control valve 1091 to connect or cut off the passage between the gas storage device 101 and the counting pool 103 when the gas storage device 101 provides negative pressure for the counting pool 103 . During the counting process of the counting pool 103, the control device 107 controls the opening of the first liquid pumping passage 109, and the gas storage device 101 pumps water into the counting pool 103 through the first liquid pumping channel 109. Extracting the sample liquid to be measured into the gas storage device 101 may mean that after the counting pool 103 starts the counting process, the control device 107 controls the fourth control valve 1091 to open, because the gas storage device at this time 101 is in a negative pressure state, so the sample liquid to be measured in the front tank of the counting tank 103 flows through the filter assembly to the rear tank under the action of the negative pressure in the gas storage device 101, and passes from the rear tank through the first liquid pumping passage. 109 flows into the gas storage device 101. The control device 107 determines the count value of the cells in the sample liquid to be tested based on the level signal generated when the cells in the sample liquid to be tested are filtered. This may mean: each cell in the sample liquid to be tested is filtered. When the small hole of the component is connected, a corresponding level signal will be generated. The counter 103 will transmit the change of the level signal to the control device 107. The control device 107 will determine the level signal to be processed according to the change of the level signal. Measure the cell count in the sample solution.

In the embodiment of the present application, the gas storage device 101 provides a stable negative pressure for the counting pool 103 through the first liquid pumping passage 109 to ensure the stable progress of the cell counting process of the sample liquid to be detected in the counting pool and effectively ensure control. The numerical accuracy of the cell counts performed within the counting cell 103 obtained by the device 107 .

In some embodiments, the sample analyzer further includes a second liquid pumping passage 110 connected between the counting cell 103 and the gas storage device 101. When the counting cell 103 completes the counting process, the control The equipment 101 controls the opening of the second liquid pumping channel 110, and the gas storage device 101 pumps the remaining sample liquid to be tested in the counting cell 103 into the gas storage device through the second liquid pumping channel 110.

Here, the second liquid pumping passage 110 includes a fifth control valve 1101 , and the fifth control valve 1101 is connected to the control device 107 . The control device 107 controls the fifth control valve 1101 to connect or cut off the passage between the gas storage device 101 and the counting tank 103 . After the counting pool 103 completes the counting process, the control device 107 immediately controls the fifth control valve 1101 to connect the passage between the gas storage device 101 and the counting pool 103. At this time, in the storage Under the negative pressure provided by the gas device 101, the remaining sample liquid to be detected in the counting cell 103 is extracted into the gas storage device 101 through the second liquid pumping passage 110, where the gas storage device 101 provides The negative pressure may be the residual negative pressure in the gas storage device 101 after the counting tank 103 has finished counting, or it may be the negative pressure re-established by the gas storage device 101 through the negative pressure passage 104 under the control of the control device 107 pressure.

In the embodiment of the present application, by setting the second liquid pumping passage 110 between the counting tank 103 and the gas storage device 101, the remaining sample liquid to be detected in the counting tank 103 can be removed to ensure the recycling of the counting tank 103. ; At the same time, the stable negative pressure in the gas storage device 101 can also enhance the complete elimination of the sample liquid to be detected in the counting cell 103.

In some embodiments, the sample analyzer also includes multiple liquid adding channels 111 connected between the counting tank 103 and the diluent. When the counting tank 103 completes the counting process, the control device 107 controls all The plurality of liquid adding passages 111 are opened at the same time, and the diluent is poured into the counting tank through the plurality of liquid adding passages 111 .

Here, the liquid adding passage 111 includes a sixth control valve 1111 , and the sixth control valve 1111 is connected to the control device 107 . The control device 107 controls the sixth control valve 1111 to connect or cut off the passage between the diluent and the counting tank 103 . The diluent is used to clean the counting cell 103 . After the counting pool 103 completes the counting process, the control device 107 controls the plurality of liquid adding channels 111 to be opened simultaneously, and the diluent is poured into the counting pool 103 through the multiple liquid adding channels 111 respectively. The front pool and the rear pool are used to clean the front pool and the rear pool of the counting pool 103 respectively.

In the embodiment of the present application, the counting tank 103 is cleaned through multiple liquid adding channels 111. First, the multiple liquid adding channels 111 can flush the counting tank 103 at multiple angles, so that the diluent can wash the wall of the counting tank 103 at multiple angles. The collision can clean the sample liquid to be detected attached to the wall of the counting pool 103, ensuring the recycling of the counting pool 103; secondly, the multiple liquid adding channels 111 can backflush the liquid for filtering cells in the counting pool 103. The small holes are flushed from the rear pool to the front pool, which improves the cleaning effect of the counting pool 103.

Optionally, when the diluent is poured into the counting tank 103 for cleaning, the control device 107 controls the fourth control valve and the fifth control valve to open, that is, the control device 107 controls the communication between the first liquid pumping passage 108 and the second liquid pumping passage 109 , so the diluent for cleaning the front tank is extracted into the gas storage device 101 through the second liquid pumping passage 109 under the negative pressure of the gas storage device 101, and the diluent for cleaning the rear tank is pumped into the gas storage device 101. 101 is extracted into the gas storage device 101 through the first liquid pumping passage 108. In this way, the cleaning and recycling of the counting pool 103 is ensured.

In some embodiments, the sample analyzer further includes a timer 112, which is connected to the control device 107; when the current pressure value in the gas storage device 101 reaches the first preset pressure value , the control device 107 controls to start the timer 112 to start timing, and when it is determined that the reading of the timer 112 reaches the first preset duration, controls the pressure relief passage 105 to open.

Here, the timer 112 is used to record the stopping time after the current pressure value in the gas storage device 101 reaches the first preset pressure value. The first preset duration may be a value preset in the control device 107 .

In the embodiment of the present application, when the negative pressure in the gas storage device 101 reaches the first preset value, by setting a pause time of the first preset length, it can be ensured that the negative pressure in the gas storage device 101 has enough time to tend to the Stable and rebalanced, it effectively solves the problem in the prior art that the built-in pressure of the gas storage device 101 is inaccurate due to the pressure source 102 being pressurized too quickly, so that the air pressure in the gas storage device 101 can be adjusted more stably and accurately. The target pressure value is reached. Furthermore, when the counting pool 103 performs the counting process, the gas storage device 101 can provide it with a negative pressure with higher accuracy and better stability.

In some embodiments, the sample analyzer further includes a flow restrictor 113, which is connected to the gas storage device 101 through the pressure relief passage 105; the control device 107 is connected to the flow restrictor 113. The component 113 is connected; when the pressure relief passage 105 is opened, the control device 107 controls to activate the current limiting component 113; when the pressure relief passage 105 is closed, the control device 107 controls to close the current limiting component 113.

Here, the flow limiting member 113 may be a flow limiting valve or a connecting pipe with a smaller diameter. The pressure relief passage 105 can be connected to atmospheric pressure through the flow restrictor 113, or can be connected to positive and negative pressure sources, that is, when the gas storage device 101 establishes positive pressure, it is connected to the negative pressure source; when the gas storage device 101 establishes negative pressure, Communicated with a positive pressure source. The connections between the flow restrictor 113 and the pressure relief passage 105 can be combined in any way.

In the embodiment of the present application, the flow restrictor 113 is used to adjust the pressure relief flow of the gas storage device 101, and the control device 107 can control it to slowly and stably release part of the negative pressure in the gas storage tank 1. Or positive pressure, which can avoid the problem of repeated pressure build-up in the gas storage device 101 due to pressure reduction overshoot, and enhances the pressure relief stability of the sample analyzer.

In some embodiments, please refer to Figure 4. This embodiment of the present application also provides a pressure-building control method including the sample analyzer described in any of the above embodiments, applied to control equipment, including:

S401: Control the opening of the pressure-building path according to the received trigger signal.

Here, the trigger signal is used to trigger the control device to start the pressure building control method, which may include at least one of the following: a start signal of the counting pool or a start signal of manually turning on the control device or automatically turning on the control device when a preset time point is reached. Start signal or stop signal when the counting pool completes the counting process. Controlling the opening of the pressure-building passage according to the received trigger signal may mean: the control device detects that the counting pool has turned on the counting mode, confirms that the counting pool requires a gas storage device to provide stable negative pressure, and then controls The first control valve is opened so that the pressure source establishes negative pressure for the gas storage device; or the control device detects the user's operation signal on its own start button and confirms that negative pressure needs to be established for the gas storage device, then Control the opening of the first control valve so that the pressure source establishes negative pressure for the gas storage device; or, the control device detects that the interval between the gas storage device and the last pressure build-up reaches a preset time, confirming that the gas storage device needs to be When the gas storage device establishes negative pressure again, the first control valve is controlled to open so that the pressure source establishes negative pressure for the gas storage device; or, the control equipment detects that the counting pool has completed the counting process and confirms that the gas storage device needs to be When the waste liquid in the gas storage device is removed, the third control valve is controlled to open so that the pressure source establishes positive pressure for the gas storage device.

S402: Receive the current pressure value detected by the pressure detection element, and when the current pressure value in the gas storage device reaches the first preset pressure value, control the current pressure value of the gas storage device at the first preset pressure value. Adjust to the second preset pressure value within a preset time range; wherein the absolute value of the first preset pressure value is greater than the absolute value of the second preset pressure value.

Here, the current pressure value detected by the pressure detection element is received, and when the current pressure value in the gas storage device reaches the first preset pressure value, the pressure-building passage is controlled to close and the Adjusting the current pressure value of the gas storage device to the second preset pressure value within the first preset time range may mean: the control device collects the current pressure value detected by the pressure detection element in real time, and adjusts the current pressure value Compare with the first preset pressure value. When the current pressure value in the gas storage device is obtained and reaches the first preset pressure value, it is confirmed that the pressure build-up of the gas storage device control needs to be suspended, that is, the control The first control valve is closed, and at the same time, the current pressure value of the gas storage device is controlled to be adjusted to a second preset pressure value within a first preset time range.

In the pressure-building control method of the sample analyzer described in the embodiment of the present application, the control device can allow the air pressure in the gas storage device to be rebalanced for a certain period of time after rapid pressure building, thereby enabling more stable and accurate operation. The air pressure in the gas storage device reaches the target pressure value, effectively avoiding the situation where the air pressure in the gas storage device is inaccurate due to pressure rebalancing after the pressure source is closed.

In some embodiments, when the current pressure value in the gas storage device is obtained and reaches the first preset pressure value, the pressure-building passage is controlled to be closed, and the current pressure value of the gas storage device is controlled to be at the first preset pressure value. Adjusting to the second preset pressure value within the preset time range includes: when the current pressure value in the gas storage device is obtained and reaches the first preset pressure value, controlling the negative pressure passage to close, and controlling the start timer to start timing. , when it is determined that the reading of the timer reaches the first preset time length, the pressure relief passage is controlled to open; when the current pressure value in the gas storage device is obtained and reaches the second preset pressure value, the The control device controls the pressure relief passage to close.

Please refer to Figure 5, which is a graph of the pressure change in the gas storage device when the control device controls the pressure source to establish a negative pressure in the gas storage device in the prior art. As can be seen from Figure 5, the control equipment controls the pressure source to start at t1 to establish negative pressure on the gas storage device, and at t2 to stop establishing negative pressure for the gas storage device. During the period from t2 to t3, the negative pressure in the gas storage device is rebalanced and reaches the target pressure value. In the embodiment of the present application, please refer to FIG. 6 , which is a graph of the pressure change in the gas storage device after the control device controls the pressure source to establish a negative pressure in the gas storage device in the embodiment of the present application. Here, when the current pressure value in the gas storage device is obtained and reaches the first preset pressure value, the negative pressure passage is controlled to close, and the timer is controlled to start timing, and it is determined that the reading of the timer reaches the first preset pressure value. For a preset time period, controlling the opening of the pressure relief passage may mean: the control device controls the pressure source to open at t4 to establish a negative pressure in the gas storage device, and when the control device obtains the current negative pressure in the gas storage device through the pressure detection element When the value reaches the first preset pressure value (i.e., t5), the first control valve is controlled to close; at the same time, the control device controls the start timer to start timing (i.e., t5), and collects the timer's data in real time. Duration value, when the collected reading of the timer reaches the first preset duration (ie, t6), the second control valve is controlled to open. When the control device detects through the pressure detection element that the negative pressure value in the gas storage device reaches the second preset pressure value (i.e., at t7), it controls the second control valve to close and determines the current negative pressure value in the gas storage device. The pressure value is the target pressure value.

In the embodiment of the present application, when the control device detects that the current negative pressure value in the gas storage device reaches the first preset pressure value, it controls the first control valve to close and waits for the first preset time period. The second control valve is controlled to open after a pause time, which can ensure that the negative pressure in the gas storage device has enough time to rebalance, effectively solving the problem in the prior art that the pressure source is pressurized too quickly. The problem of inaccurate built-in pressure in the gas storage device is eliminated, so that the air pressure in the gas storage device can reach the target pressure value more stably and accurately. Therefore, when the counting pool performs the counting process, the gas storage device can provide a negative pressure with higher accuracy and better stability.

In some embodiments, when the current pressure value in the gas storage device is obtained and reaches the first preset pressure value, the pressure-building passage is controlled to be closed, and the current pressure value of the gas storage device is controlled to be at the first preset pressure value. Adjusting to the second preset pressure value within the preset time range includes: when the current pressure value in the gas storage device is obtained and reaches the third preset pressure value, controlling the positive pressure passage to close and controlling the timer to start timing, When it is determined that the reading of the timer reaches the second preset time period, the pressure relief passage is controlled to open; when the current pressure value in the gas storage device reaches the second preset pressure value, the control device controls The pressure relief passage is closed.

Here, please refer to FIG. 7 , which is a graph of the pressure change in the gas storage device when the control device controls the pressure source to establish a positive pressure in the gas storage device in the embodiment of the present application. When the current pressure value in the gas storage device is obtained and reaches the third preset pressure value, the positive pressure passage is controlled to close, and the timer is controlled to start timing, and it is determined that the reading of the timer reaches the second preset time length. When, controlling the opening of the pressure relief passage may mean: the control device controls the pressure source to open at t8 to establish a positive pressure in the gas storage device. When the control device obtains the current positive pressure value in the gas storage device through the pressure detection element and reaches the third At three preset pressure values (i.e., t9), the third control valve is controlled to close; at the same time, the control device controls the start timer to start timing (i.e., t9), and collects the duration value of the timer in real time, When the collected reading of the timer reaches the first preset time period (that is, at t10), the second control valve is controlled to open. When the control device detects through the pressure detection element that the positive pressure value in the gas storage device reaches the fourth preset pressure value (i.e., at t11), it controls the second control valve to close and determines the current positive pressure value in the gas storage device. The pressure value is the target pressure value.

In the embodiment of the present application, when the control device detects that the current positive pressure value in the gas storage device reaches the third preset pressure value, it controls the third control valve to close and waits for the second preset time period. The second control valve is controlled to open after a pause time, which can ensure that the positive pressure in the gas storage device has enough time to rebalance, effectively solving the problem in the prior art that the pressure source is pressurized too quickly. The problem of inaccurate built-in pressure in the gas storage device is eliminated, so that the air pressure in the gas storage device can reach the target pressure value more stably and accurately.

In some embodiments, the sample analyzer in any of the above embodiments can be a blood cell analyzer, which is used to analyze the blood cells of the sample. For example, the blood cell analyzer is used to analyze blood cells such as red blood cells, platelets, and white blood cells. Determination.

Specifically, the counting cell 103 of the blood cell analyzer can be an impedance detection counting cell, and the gas storage device 101 is used to drive the sample liquid to be detected in the front cell to flow to the rear cell under pressure. When each cell in the sample liquid to be detected When passing through the small holes of the cell filter component, a corresponding level signal will be generated, and the counter 103 will transmit the changes in the level signal to the control device 107, thereby realizing the counting of blood cells in the sample liquid to be tested through the Coulter method. The control device 107 is used to control the pressure value of the gas storage device 101 so that the air pressure in the gas storage device 101 has a certain period of time to rebalance after rapid pressure build-up, thereby improving the stability of the air pressure in the gas storage device 101 and improving the blood cell analyzer. detection accuracy.

In order to facilitate understanding, the embodiment of the present application provides a more overall description of the use method of the sample analyzer. Please refer to Figure 8. The method is applied to the control device, including:

S801: The control equipment detects that the interval between the gas storage device and the last pressure build-up reaches the preset time, and controls the first control valve to open so that the pressure source establishes negative pressure for the gas storage device;

S802: When the control device detects that the current negative pressure value of the gas storage device reaches the first preset pressure value through the pressure detection element, it controls the first control valve to close, and at the same time, the control device controls the timer to start timing;

S803: When the control device detects that the counting time of the timer reaches the first preset time, it controls the second control valve to open;

S804: When the control equipment detects that the current negative pressure value of the gas storage device reaches the second preset pressure value, it controls the second control valve to close;

S805: The control equipment controls the fourth control valve to open so that the gas storage device provides stable negative pressure for the counting pool, and the counting pool executes the counting process;

S806: The control device detects that the counting pool has completed the counting process, and controls to open the fifth control valve to extract the remaining sample liquid to be tested in the counting pool to the gas storage device;

S807: The control equipment controls the opening of the sixth control valve to inject the diluent into the counting tank for cleaning; here, the diluent for cleaning the front tank is extracted to the gas storage device through the second liquid pumping passage; the diluent for cleaning the rear tank is The liquid is extracted to the gas storage device through the first liquid pumping passage;

S808: The control equipment controls the fourth control valve, the fifth control valve, and the sixth control valve to close, and controls the third control valve to open to establish positive pressure on the gas storage device;

S809: When the control equipment detects that the current positive pressure value of the gas storage device reaches the third preset pressure value through the pressure detection element, it controls the third control valve to close, and at the same time, the control equipment controls the timer to start timing;

S810: When the control device detects that the counting time of the timer reaches the second preset time, it controls the second control valve to open;

S811: When the control equipment detects that the current positive pressure value of the gas storage device reaches the fourth preset pressure value, it controls the second control valve to close;

S812: The control device controls the discharge of waste liquid in the gas storage device.

The pressure-building control method of the sample analyzer described in the embodiment of the present application can ensure that the negative pressure or positive pressure in the gas storage device has sufficient time to rebalance, effectively solving the problem in the prior art due to pressure source pressurization. Too fast will cause the problem of inaccurate built-in pressure in the gas storage device, so that the air pressure in the gas storage device can reach the target pressure value more stably and accurately.

[Correction under Rule 91 27.02.2023]

Figure 9 shows an internal structure diagram of a computer device in one embodiment. Specifically, the computer device may be a terminal or a server. As shown in Figure 9, the computer device includes a processor, a memory and a network interface connected through a system bus. Among them, memory includes non-volatile storage media and internal memory. The non-volatile storage medium of the computer device stores an operating system and may also store a computer program. When the computer program is executed by the processor, it can cause the processor to implement the above method. The internal memory may also store a computer program. When the computer program is executed by the processor, it can cause the processor to perform the above method. Those skilled in the art can understand that the structure shown in Figure 9 is only a block diagram of a partial structure related to the solution of the present application, and does not constitute a limitation on the computer equipment to which the solution of the present application is applied. Specific computer equipment can May include more or fewer parts than shown, or combine certain parts, or have a different arrangement of parts.

In one embodiment, a computer device is proposed, including a memory and a processor. The memory stores a computer program. When the computer program is executed by the processor, the processor executes the execution as shown in FIG. 1 or FIG. 2 steps of the method shown.

In one embodiment, a computer-readable storage medium is proposed, which stores a computer program. When the computer program is executed by a processor, the processor performs the following steps of the method shown in Figure 4 or Figure 8 .

Those of ordinary skill in the art can understand that all or part of the processes in the methods of the above embodiments can be implemented by instructing relevant hardware through computer programs. The programs can be stored in a non-volatile computer-readable storage medium. , when the program is executed, it may include the processes of the above-mentioned method embodiments. Any reference to memory, storage, database or other media used in the embodiments provided in this application may include non-volatile and/or volatile memory. Non-volatile memory may include read-only memory (ROM), programmable ROM (PROM), electrically programmable ROM (EPROM), electrically erasable programmable ROM (EEPROM), or flash memory. Volatile memory may include random access memory (RAM) or external cache memory. By way of illustration and not limitation, RAM is available in many forms, such as static RAM (SRAM), dynamic RAM (DRAM), synchronous DRAM (SDRAM), double data rate SDRAM (DDRSDRAM), enhanced SDRAM (ESDRAM), synchronous chain Synchlink DRAM (SLDRAM), memory bus (Rambus) direct RAM (RDRAM), direct memory bus dynamic RAM (DRDRAM), and memory bus dynamic RAM (RDRAM), etc.

The technical features of the above embodiments can be combined in any way. To simplify the description, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, all possible combinations should be used. It is considered to be within the scope of this manual.

The above are only specific embodiments of the present application, but the protection scope of the present application is not limited thereto. Any person familiar with the technical field can easily think of changes or substitutions within the technical scope disclosed in the present application. All are covered by the protection scope of this application. Therefore, the protection scope of this application should be subject to the protection scope of the claims.

Claims

A sample analyzer, which includes a counting cell and a control device, the sample analyzer further includes at least one of a gas storage device and a pressure source, the gas storage device is connected to the pressure source and the counting cell, A pressure building passage is connected between the gas storage device and the pressure source, and a pressure detection element is connected to the gas storage device;

The control device is connected to the pressure building passage and the pressure detection element; wherein the pressure detection element is used to detect the current pressure value in the gas storage device;

When the counting pool is in a preset state, the control device controls the pressure-building passage to open, and the pressure source builds pressure on the gas storage device;

When the current pressure value in the gas storage device reaches the first preset pressure value, the control device controls the pressure building passage to close, and controls the current pressure value of the gas storage device to be within the first preset time range. Adjust to the second preset pressure value; wherein the absolute value of the first preset pressure value is greater than the absolute value of the second preset pressure value.
The sample analyzer of claim 1, wherein the sample analyzer further includes a timer, and the timer is connected to the control device;

Before controlling the current pressure value of the gas storage device to adjust to the second preset pressure value within the first preset time range, the method further includes:

When the current pressure value in the gas storage device reaches the first preset pressure value, the control device controls the pressure-building passage to close, and controls to start the timer to start timing, and determines the time limit of the timer. The reading reaches the preset length of time.
The sample analyzer of claim 2, wherein the sample analyzer further includes a pressure relief passage, and the pressure relief passage is connected to the control device;

When the current pressure value in the gas storage device reaches the first preset pressure value, the control device controls the pressure building passage to close, and controls the current pressure value of the gas storage device to close at the first preset time. Adjust to the second preset pressure value within the range, including:

When the current pressure value in the gas storage device reaches the first preset pressure value, the control device controls the pressure-building passage to close, and controls to start the timer to start timing, and determines the time limit of the timer. When the reading reaches the preset time period, the pressure relief passage is controlled to open;

The gas storage device performs pressure relief through the pressure relief passage. When the current pressure value in the gas storage device reaches a second preset pressure value, the control device controls the pressure relief passage to close.
The sample analyzer of claim 3, wherein the pressure-building path includes a negative pressure path, and the control device is connected to the negative pressure path and the pressure detection element;

When the counting pool is opened for counting, the control device controls the opening of the negative pressure passage and the closing of the pressure relief passage, and the pressure source establishes negative pressure on the gas storage device;

When the current pressure value in the gas storage device reaches the first preset pressure value, the control device controls the negative pressure passage to close, and controls to start the timer to start timing, and determines that the reading of the timer reaches During the first preset time period, control the opening of the pressure relief passage;

The gas storage device releases pressure through the pressure relief passage. When the current pressure value in the gas storage device reaches a second preset pressure value, the control device controls the pressure relief passage to close, so The above counting pool executes the counting process.
The sample analyzer of claim 3, wherein the pressure-building path includes a positive pressure path,

The control device is connected to the positive pressure passage and the pressure detection element;

When the counting pool stops counting, the control device controls the positive pressure passage to open and the pressure relief passage to close, and the pressure source establishes positive pressure on the gas storage device;

When the current pressure value in the gas storage device reaches the first preset pressure value, the control device controls the positive pressure passage to close and starts the timer to start timing, and determines that the reading of the timer reaches the first preset pressure value. 2. Control the opening of the pressure relief passage during a preset time period;

The gas storage device releases pressure through the pressure relief passage. When the current pressure value in the gas storage device reaches a second preset pressure value, the control device controls the pressure relief passage to close, so The gas storage device executes a waste liquid discharge process.
The sample analyzer of claim 5, wherein the positive pressure passage includes a third control valve, the third control valve is connected to the control device, and the control device is used to control the third control valve. When the pressure source establishes positive pressure on the gas storage device, the passage between the pressure source and the gas storage device is connected or cut off.
The sample analyzer of claim 4, wherein the negative pressure passage includes a first control valve, the first control valve is connected to the control device, and the control device is used to control the first control valve. When the pressure source establishes negative pressure on the gas storage device, the passage between the pressure source and the gas storage device is connected or cut off.
The sample analyzer of claim 4, further comprising a first liquid pumping passage connected between the counting cell and the gas storage device,

During the counting process of the counting pool, the control device controls the opening of the first liquid pumping passage, and the gas storage device uses the current pressure inside the gas storage device and the first liquid pumping channel to drain the gas in the counting pool. The sample liquid to be tested is extracted into the gas storage device, and the control device determines the count value of the cells in the sample liquid to be tested based on the level signal generated when the cells in the sample liquid to be tested are filtered.
The sample analyzer of claim 8, wherein the first liquid pumping passage includes a fourth control valve, the fourth control valve is connected to the control device, and the control device is used to control the fourth The control valve connects or cuts off the passage between the gas storage device and the counting tank when the gas storage device provides pressure for the counting tank.
The sample analyzer according to claim 4, further comprising a second liquid pumping passage connecting the counting cell and the gas storage device,

When the counting cell completes the counting process, the control device controls the second liquid pumping passage to open, and the gas storage device draws the remaining sample liquid to be tested in the counting cell through the second liquid pumping passage. into the gas storage device.
The sample analyzer of claim 10, wherein the second liquid pumping passage includes a fifth control valve, the fifth control valve is connected to the control device, and the control device is used to control the fifth The control valve connects or cuts off the passage between the gas storage device and the counting tank.
The sample analyzer according to claim 1, wherein the counting pool includes an impedance detection counting pool, the impedance detection counting pool includes a front pool, a rear pool and a cell filter located between the front pool and the rear pool. Assembly, the front tank is used to hold the sample liquid to be detected, and the gas storage device is used to drive the sample liquid to be detected in the front tank to flow to the rear tank under pressure; or,

The counting cell includes an optical detection and counting cell, the optical detection and counting cell includes a flow chamber, and the gas storage device is used to drive the sheath liquid to flow in the flow chamber under pressure.
The sample analyzer according to claim 1, further comprising a plurality of liquid adding channels connecting the counting tank and the diluent,

When the counting pool completes the counting process, the control device controls the plurality of liquid adding channels to be opened simultaneously, and the diluent is poured into the counting pool through the multiple liquid adding channels.
The sample analyzer of claim 13, wherein the liquid adding channel includes a sixth control valve, the sixth control valve is connected to the control device, and the control device is used to control the sixth control valve. Connect or cut off the passage between the diluent and the counting cell.
The sample analyzer according to claim 3, further comprising a flow restricting member connected to the gas storage device through the pressure relief passage; the flow restricting member is used to adjust the gas storage device. Pressure relief flow of the device.
The sample analyzer of claim 1, wherein the sample analyzer is a blood cell analyzer.
A pressure-building control method for a sample analyzer according to any one of claims 1 to 16, applied to control equipment, which includes:

Control the opening of the pressure-building path according to the received trigger signal;

Receive the current pressure value in the gas storage device detected by the pressure detection element, and when the current pressure value in the gas storage device reaches the first preset pressure value, control the pressure-building passage to close; And control the current pressure value of the gas storage device to adjust to a second preset pressure value within a first preset time range, wherein the absolute value of the first preset pressure value is greater than the absolute value of the second preset pressure value.
The pressure building control method according to claim 17, wherein the sample analyzer further includes a timer, and the timer is connected to the control device;

Before controlling the current pressure value of the gas storage device to adjust to the second preset pressure value within the first preset time range, the method further includes:

When the current pressure value in the gas storage device reaches the first preset pressure value, the control device controls the pressure-building passage to close, and controls to start the timer to start timing, and determines the time limit of the timer. The reading reaches the preset length of time.
The pressure building control method according to claim 18, wherein the sample analyzer further includes a pressure relief passage, and the pressure relief passage is connected to the control device;

When the current pressure value in the gas storage device reaches the first preset pressure value, the control device controls the pressure building passage to close, and controls the current pressure value of the gas storage device to close at the first preset time. Adjust to the second preset pressure value within the range, including:

When the current pressure value in the gas storage device reaches the first preset pressure value, the control device controls the pressure-building passage to close, and controls to start the timer to start timing, and determines the time limit of the timer. When the reading reaches the preset time period, the pressure relief passage is controlled to open;

The gas storage device performs pressure relief through the pressure relief passage. When the current pressure value in the gas storage device reaches a second preset pressure value, the control device controls the pressure relief passage to close.
The pressure building control method according to claim 19, wherein the pressure building path includes a negative pressure path,

The control device is connected to the negative pressure passage and the pressure detection element;

When the counting pool is opened for counting, the control device controls the negative pressure passage to open and the pressure relief passage to close, so that the pressure source establishes negative pressure on the gas storage device;

When it is obtained that the current pressure value in the gas storage device reaches the first preset pressure value, the pressure building passage is controlled to close, and the current pressure value of the gas storage device is controlled to be adjusted within the first preset time range. The second preset pressure value includes:

When the current pressure value in the gas storage device is obtained and reaches the first preset pressure value, the negative pressure passage is controlled to close, and the timer is controlled to start timing, and it is determined that the timer reading reaches the first preset time period. , control the opening of the pressure relief passage;

When the current pressure value in the gas storage device is obtained and reaches the second preset pressure value, the control device controls the pressure relief passage to close.
The pressure building control method according to claim 19, wherein the pressure building passage includes a positive pressure passage,

The control device is connected to the positive pressure passage and the pressure detection element;

When the counting tank stops counting, the control device controls the positive pressure passage to open and the pressure relief passage to close, so that the pressure source establishes positive pressure on the gas storage device;

When it is obtained that the current pressure value in the gas storage device reaches the first preset pressure value, the pressure building passage is controlled to close, and the current pressure value of the gas storage device is controlled to be adjusted within the first preset time range. The second preset pressure value includes:

When it is obtained that the current pressure value in the gas storage device reaches the first preset pressure value, the positive pressure passage is controlled to close, and the timer is controlled to start timing, and it is determined that the reading of the timer reaches the second preset time length, The pressure relief passage is controlled to open; when the current pressure value in the gas storage device reaches a second preset pressure value, the control device controls the pressure relief passage to close.