CN110031644A - Agent delivery device, sample analyser and agent delivery method - Google Patents
Agent delivery device, sample analyser and agent delivery method Download PDFInfo
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- CN110031644A CN110031644A CN201910310887.7A CN201910310887A CN110031644A CN 110031644 A CN110031644 A CN 110031644A CN 201910310887 A CN201910310887 A CN 201910310887A CN 110031644 A CN110031644 A CN 110031644A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
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Abstract
The present invention discloses a kind of agent delivery device, including constant displacement pump, the first switch piece, first pressure source and second pressure source, constant displacement pump has diaphragm and liquid chamber and cooperation room positioned at diaphragm two sides, first switch piece is connected between liquid chamber and first pressure source, first pressure source is for changing the indoor pressure of liquid, second pressure source is for changing indoor pressure is cooperated, and by the mobile diaphragm of pressure difference between liquid chamber and cooperation room, first pressure source and second pressure source are all positive pressure or are all negative pressure.The feed flow of agent delivery device of the present invention is in stable condition.Invention additionally discloses a kind of sample analysers and a kind of agent delivery method.
Description
It is on June 30th, 2017 that the application, which is the applying date, application No. is 201710532475.9, entitled " feed flow
The divisional application of the patent application of the feed liquid method of device, sample analyser and liquid feed device ".
Technical field
The present invention relates to the field of medical instrument technology more particularly to a kind of agent delivery device, a kind of sample analyser with
A kind of and agent delivery method.
Background technique
Constant displacement pump is generallyd use in current cellanalyzer, in liquid feed device carries out quantitative liquid feeding.The gas of constant displacement pump
Room connects negative pressure to extract liquid, and the gas chamber connection positive pressure of constant displacement pump is to release liquid, to realize quantitative liquid feeding.Due to quantitative
Switched when pump work using positive/negative-pressure, cellanalyzer is difficult to provide stable positive pressure and stable negative pressure simultaneously, therefore holds
Easily lead to constant displacement pump unstable working condition, the feed flow state labile of liquid feed device, so that the detection knot of cellanalyzer
Fruit accuracy is impacted.
Summary of the invention
Technical problem to be solved by the present invention lies in provide a kind of agent delivery device that feed flow is in stable condition, sample point
Analyzer and agent delivery method.
To achieve the goals above, embodiment of the present invention adopts the following technical scheme that
In a first aspect, providing a kind of agent delivery device, including constant displacement pump, the first switch piece, first pressure source and
Two pressure source, the constant displacement pump have diaphragm and liquid chamber and cooperation room positioned at the diaphragm two sides, the first switch piece company
Be connected between the liquid chamber and the first pressure source, the first pressure source for changing the liquid chamber pressure, described
Two pressure source connects the cooperation room and provides pressure for it, passes through the mobile institute of pressure difference between the liquid chamber and the cooperation room
Diaphragm is stated, the first pressure source and the second pressure source are all positive pressure or are all negative pressure.
Wherein, the first pressure source and the second pressure source are positive pressure；
First switch piece is also connected to atmosphere or the 4th pressure source, and the pressure absolute value of the 4th pressure source is low
Pressure absolute value in the second pressure source；4th pressure source provides negative pressure.
Wherein, the first pressure source and the second pressure source are negative pressure；
First switch piece is also connected to atmosphere or the 6th pressure source, and the pressure absolute value of the 6th pressure source is lower than
The pressure absolute value in the second pressure source；6th pressure source provides positive pressure.
Wherein, the agent delivery device further includes liquid storage tank, and the liquid storage tank is connected to the liquid chamber.
Wherein, the pressure in the second pressure source is different from the pressure in the first pressure source.
Wherein, the first pressure source and the first switch piece change the pressure of the liquid chamber.
On the other hand, a kind of sample analyser is also provided, comprising:
Sampling component has sampler, the samplers sample and distribution sample；
Reaction component, has at least one reaction tank, and the sampler distributes the sample into reaction tank, prepares to be measured
Liquid；
Agent delivery device, including constant displacement pump, the first switch piece, first pressure source and second pressure source, it is described quantitative
Pump have diaphragm and positioned at the diaphragm two sides liquid chamber and cooperation room, first switch piece be connected to the liquid chamber with it is described
Between first pressure source, the first pressure source and the first switch piece change the pressure of the liquid chamber, and the second pressure source connects
It connects the cooperation room and provides pressure for it, pass through the mobile diaphragm of pressure difference between the liquid chamber and the cooperation room, institute
It states first pressure source and the second pressure source is all positive pressure or is all negative pressure, the first pressure source and/or second pressure
Power source includes air pump and air accumulator, and the air pump is in built-in pressure or the negative pressure of attentioning of the air accumulator；
Detection components have flow chamber, and the prepare liquid flows through the flow chamber, obtain detection information；With
Controller is coupled with the sampling component, reaction component, agent delivery device, detection components, controls its movement simultaneously
It handles the detection information and obtains analysis result.
Wherein, the first pressure source is negative pressure, and the first pressure source provides negative pressure by reaction tank for the liquid chamber.
Wherein, the sample analyser further includes liquid storage tank, and the liquid storage tank is connected to the liquid chamber, further, institute
Stating first pressure source is positive pressure, and the first pressure source provides positive pressure by the liquid storage tank for the liquid chamber.
In another aspect, also provide a kind of agent delivery method of sample analyser, the sample analyser include constant displacement pump,
First pressure source and second pressure source, the constant displacement pump have diaphragm and liquid chamber and cooperation room positioned at the diaphragm two sides, institute
Stating first pressure source and the second pressure source is all positive pressure, which comprises
Cooperation room and the second pressure source described in continual communication；It is connected to the liquid chamber and the first pressure source, so that
The pressure of the liquid chamber is greater than the pressure of the cooperation room, and the diaphragm is mobile to room joined together under differential pressure action, liquid into
Enter the liquid chamber；The liquid chamber and the first pressure source are disconnected, so that the pressure of the cooperation room is greater than the pressure of the liquid chamber
Power, the diaphragm is mobile to the liquid chamber under differential pressure action, and the liquid flows out the liquid chamber to carry out feed flow.
Wherein, the liquid chamber is also connected to atmosphere or the 4th pressure source, and the pressure absolute value of the 4th pressure source is low
Pressure absolute value in the second pressure source；Preferably, the 4th pressure source provides negative pressure.
Yet another aspect, also provides a kind of agent delivery method of sample analyser, and the sample analyser includes quantitative
Pump, first pressure source and second pressure source, the constant displacement pump have diaphragm and liquid chamber and cooperation room positioned at the diaphragm two sides,
The first pressure source and the second pressure source are all negative pressure, which comprises
Cooperation room and the second pressure source described in continual communication；The liquid chamber and the first pressure source are disconnected, so that
The pressure of the liquid chamber is greater than the pressure of the cooperation room, and the diaphragm is mobile to room joined together under differential pressure action, liquid into
Enter the liquid chamber；It is connected to the liquid chamber and the first pressure source, so that the pressure of the cooperation room is greater than the pressure of the liquid chamber
Power, the diaphragm is mobile to the liquid chamber under differential pressure action, and the liquid flows out the liquid chamber to carry out feed flow.
Wherein, the liquid chamber is also connected to atmosphere or the 6th pressure source, and the pressure absolute value of the 6th pressure source is low
Pressure absolute value in the second pressure source；Preferably, the 6th pressure source provides positive pressure.
Wherein, the first pressure source and/or the second pressure source include air accumulator, and air pressure builds in the air accumulator
Press through journey are as follows:
The pressure that pressure absolute value is greater than preset value is established in the air accumulator；With
The air accumulator is connected to atmosphere, the pressure absolute value of the pressure is made to be reduced to the preset value.
Compared to the prior art, the invention has the following advantages:
When first switch piece is connected to the liquid chamber and the first pressure source, the first pressure source changes the liquid
Indoor pressure, second pressure source is continuously cooperation room and provides pressure, so that generating pressure between the liquid chamber and the cooperation room
Power is poor, and the diaphragm moves under pressure difference effect, so that the constant displacement pump imbibition or drain.So first pressure
Power source and the second pressure source are the power source for pushing the diaphragm mobile, namely the driving constant displacement pump drain or imbibition
Power source.Since the first pressure source and the second pressure source are all positive pressure or are all negative pressure, the constant displacement pump
Power source is positive pressure or negative pressure, and the sample analyser is capable of providing stable, reliable positive pressure or negative pressure, so as to avoid
Constant displacement pump is stated to need while relying on positive pressure and the problem of negative pressure is driven and leads to unstable working condition, the constant displacement pump
Stable working state advantageously ensures that the detection of the sample analyser so that the agent delivery device feed flow is in stable condition
As a result accuracy.In addition, can be not provided with switch piece between second pressure source and cooperation room, can further save cost.
Detailed description of the invention
In order to illustrate more clearly of technical solution of the present invention, attached drawing needed in embodiment will be made below
Simply introduce, it should be apparent that, the accompanying drawings in the following description is only some embodiments of the present invention, general for this field
For logical technical staff, without creative efforts, other attached drawings can also be obtained such as these attached drawings.
Fig. 1 is a kind of schematic diagram of embodiment of liquid feed device provided in an embodiment of the present invention.
Fig. 2 is the schematic diagram of the another embodiment of liquid feed device provided in an embodiment of the present invention.
Fig. 3 is the schematic diagram of the section components of liquid feed device provided in an embodiment of the present invention.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention is described, and shows
So, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based on the reality in the present invention
Example is applied, every other embodiment obtained by those of ordinary skill in the art without making creative efforts all belongs to
In the scope of protection of the invention.
In addition, the explanation of following embodiment is referred to the additional illustration, the spy that can be used to implement to illustrate the present invention
Determine embodiment.Direction terms mentioned in the present invention, for example, "upper", "lower", "front", "rear", "left", "right", "inner",
"outside", " side " etc. are only the directions with reference to annexed drawings, and therefore, the direction term used is to more preferably, more clearly say
The bright and understanding present invention, rather than indicate or imply signified device or element and must have a particular orientation, with specific square
Position construction and operation, therefore be not considered as limiting the invention.
In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, term " installation ", " phase
Even ", " connection ", " be arranged exist ... on " shall be understood in a broad sense, for example, it may be being fixedly connected, be also possible to removably connect
It connects, or is integrally connected；It can be mechanical connection；It can be directly connected, can also indirectly connected through an intermediary, it can
To be the connection inside two elements.For the ordinary skill in the art, above-mentioned term can be understood with concrete condition
Concrete meaning in the present invention.
In addition, in the description of the present invention, unless otherwise indicated, the meaning of " plurality " is two or more.In addition,
Refer to the numerical value for recording "~" front and back as minimum value and maximum value with the numberical range that "~" indicates in this specification
The range being included.In the accompanying drawings, structurally similar or identical unit is indicated by the same numeral.
The embodiment of the present invention provides a kind of sample analyser.The sample analyser can be used for carrying out biological sample analysis,
The biological sample can be blood, urine etc..
Also referring to Fig. 1 and Fig. 2, the sample analyser includes liquid feed device 100, and the liquid feed device 100 can
Realize quantitative liquid feeding.
The liquid feed device 100 includes constant displacement pump 1, the first switch piece 2, the second switch piece 3, first pressure source 4 and the
Two pressure source 5.The constant displacement pump 1 has diaphragm 11 and liquid chamber 12 and gas chamber 13 positioned at 11 two sides of diaphragm.Described first
Switch piece 2 is connected between the liquid chamber 12 and the first pressure source 4.Second switch piece 3 is connected to the gas chamber 13
Between the second pressure source 5.The first pressure source 4 is for changing the pressure in the liquid chamber 12.The second pressure
Source 5 is for changing the pressure in the gas chamber 13.By described in the pressure difference movement between the liquid chamber 12 and the gas chamber 13
Diaphragm 11.The first pressure source 4 and the second pressure source 5 are all positive pressure or are all negative pressure.
In the present embodiment, when first switch piece 2 is connected to the liquid chamber 12 with the first pressure source 4, described the
One pressure source 4 changes the pressure in the liquid chamber 12, so that pressure difference is generated between the liquid chamber 12 and the gas chamber 13, it is described
Diaphragm 11 moves under pressure difference effect, so that 1 imbibition of the constant displacement pump or drain.Second switch piece 3 is connected to institute
When stating gas chamber 13 and the second pressure source 5, the second pressure source 5 changes the pressure in the gas chamber 13, so that the gas
Pressure difference is generated between room 13 and the liquid chamber 12, the diaphragm 11 moves under pressure difference effect, so that described quantitative
Pump 1 drain or imbibition.So the first pressure source 4 and the second pressure source 5 are the power for pushing the diaphragm 11 mobile
Source, namely the power source of driving 1 drain of constant displacement pump or imbibition.Due to the first pressure source 4 and the second pressure source 5
It is all positive pressure or is all negative pressure, therefore the power source of the constant displacement pump 1 is positive pressure or negative pressure, the sample analyser is capable of providing
Stable, reliable positive pressure or negative pressure, so as to avoid the constant displacement pump 1 from needing and meanwhile rely on positive pressure and negative pressure is driven and
The problem of leading to unstable working condition, the stable working state of the constant displacement pump 1, so that the liquid feed device 100 is for liquid
State is stablized, and advantageously ensures that the accuracy of the testing result of the sample analyser.
As shown in Figure 1, the first pressure source 4 and the second pressure source 5 are positive as a kind of alternative embodiment
Pressure.When first switch piece 2 is connected to the liquid chamber 12 with the first pressure source 4, the first pressure source 4 increases the liquid
Pressure in room 12, so that generating pressure difference between the liquid chamber 12 and the gas chamber 13, the diaphragm 11 is acted in pressure difference
When lower mobile to the direction of the gas chamber 13,12 volume of liquid chamber increases, and liquid enters the liquid chamber 12, the constant displacement pump 1
Complete imbibition.When second switch piece 3 is connected to the gas chamber 13 with the second pressure source 5, the second pressure source 5 is increased
Pressure in the gas chamber 13, so that generate pressure difference between the gas chamber 13 and the liquid chamber 12, the diaphragm 11 is in pressure
When mobile to the direction of the liquid chamber 12 under difference effect, 12 volume of liquid chamber reduces, and liquid flows out the liquid chamber 12, described fixed
Amount pump 1 completes drain.
It is understood that driving difficulty is small when the constant displacement pump 1 is using two-way positive pressure driving method, advantageously reduce
The energy consumption in the first pressure source 4 and the second pressure source 5, to reduce the energy consumption of the sample analyser.
Optionally, second switch piece 3 is also used to the company when first switch piece 2 is connected to the first pressure source 4
Atmosphere or third pressure source (illustrating in Fig. 1 with hollow ellipse) are passed to, the pressure absolute value of the third pressure source is lower than institute
State the pressure absolute value in first pressure source.At this point, it is more prone to produce pressure difference between the liquid chamber 12 and the gas chamber 13, it is described
First pressure source 4 pushes the diaphragm 11 smaller to the mobile difficulty in the direction of the gas chamber 13, advantageously reduces described first
The energy consumption of pressure source 4, the 1 imbibition difficulity of the movment of constant displacement pump is small and stablizes.Due to the pressure absolute value of the third pressure source
Lower than the pressure absolute value in the first pressure source 4, therefore the first pressure source 4 still plays a part of mainly to drive, described
Third pressure source plays auxiliary drive, even if the third pressure source has fluctuation, also hardly influences the diaphragm
11 shift action, the constant displacement pump 1 can still keep stable working condition, and 100 feed flow of liquid feed device is in stable condition.
Preferably, the third pressure source provides negative pressure, plays the role of auxiliary drive.
First switch piece 2 is also used to be connected to atmosphere when second switch piece 3 is connected to the second pressure source 5
Or the 4th pressure source (being illustrated in Fig. 1 with hollow ellipse), the pressure absolute value of the 4th pressure source is lower than second pressure
The pressure absolute value in power source.At this point, being more prone to produce pressure difference, the second pressure between the gas chamber 13 and the liquid chamber 12
Source 5 pushes the diaphragm 11 smaller to the mobile difficulty in the direction of the liquid chamber 12, advantageously reduces the second pressure source 5
Energy consumption, the 1 drain difficulity of the movment of constant displacement pump is small and stablizes.Since the pressure absolute value of the 4th pressure source is lower than described the
The pressure absolute value of two pressure source 5, therefore the second pressure source 5 still plays a part of mainly to drive, the 4th pressure source
Play auxiliary drive, even if the 4th pressure source has fluctuation, the movement for also hardly influencing the diaphragm 11 is dynamic
Make, the constant displacement pump 1 can still keep stable working condition, and 100 feed flow of liquid feed device is in stable condition.Preferably, institute
It states the 4th pressure source and negative pressure is provided, play the role of auxiliary drive.
As shown in Fig. 2, the first pressure source 4 and the second pressure source 5 are negative as a kind of alternative embodiment
Pressure.When first switch piece 2 is connected to the liquid chamber 12 with the first pressure source 4, the first pressure source 4 reduces the liquid
Pressure in room 12, so that generating pressure difference between the liquid chamber 12 and the gas chamber 13, the diaphragm 11 is acted in pressure difference
When lower mobile to the direction of the liquid chamber 12,12 volume of liquid chamber reduces, and liquid flows out the liquid chamber 12, the constant displacement pump 1
Complete drain.When second switch piece 3 is connected to the gas chamber 13 with the second pressure source 5, the second pressure source 5 is reduced
Pressure in the gas chamber 13, so that generate pressure difference between the gas chamber 13 and the liquid chamber 12, the diaphragm 11 is in pressure
When mobile to the direction of the gas chamber 13 under difference effect, 12 volume of liquid chamber increases, and liquid enters the liquid chamber 12, described fixed
Amount pump 1 completes imbibition.
Optionally, second switch piece 3 is also used to the company when first switch piece 2 is connected to the first pressure source 4
Atmosphere or the 5th pressure source (illustrating in Fig. 2 with Filled Ellipse) are passed to, the pressure absolute value of the 5th pressure source is lower than institute
State the pressure absolute value in first pressure source.At this point, it is more prone to produce pressure difference between the gas chamber 13 and the liquid chamber 12, it is described
Second pressure source 5 pushes the diaphragm 11 smaller to the mobile difficulty in the direction of the liquid chamber 12, advantageously reduces described second
The energy consumption of pressure source 5, the 1 drain difficulity of the movment of constant displacement pump is small and stablizes.Due to the pressure absolute value of the 5th pressure source
Lower than the pressure absolute value in the first pressure source 4, therefore the first pressure source 4 still plays a part of mainly to drive, described
5th pressure source plays auxiliary drive, even if the 5th pressure source has fluctuation, also hardly influences the diaphragm
11 shift action, the constant displacement pump 1 can still keep stable working condition, and 100 feed flow of liquid feed device is in stable condition.
Preferably, the 5th pressure source provides positive pressure, plays the role of auxiliary drive.
First switch piece 2 is also used to be connected to atmosphere when second switch piece 3 is connected to the second pressure source 5
Or the 6th pressure source (being illustrated in Fig. 2 with Filled Ellipse), the pressure absolute value of the 6th pressure source is lower than second pressure
The pressure absolute value in power source.At this point, being more prone to produce pressure difference, the first pressure between the liquid chamber 12 and the gas chamber 13
Source 4 pushes the diaphragm 11 smaller to the mobile difficulty in the direction of the gas chamber 13, advantageously reduces the first pressure source 4
Energy consumption, the 1 imbibition difficulity of the movment of constant displacement pump is small and stablizes.Since the pressure absolute value of the 6th pressure source is less than described the
The pressure absolute value of two pressure source 5, therefore the second pressure source 5 still plays a part of mainly to drive, the 6th pressure source
Play auxiliary drive, even if the 6th pressure source has fluctuation, the movement for also hardly influencing the diaphragm 11 is dynamic
Make, the constant displacement pump 1 can still keep stable working condition, and 100 feed flow of liquid feed device is in stable condition.Preferably, institute
It states the 6th pressure source and positive pressure is provided, play the role of auxiliary drive.
Also referring to Fig. 1 and Fig. 2, as a kind of alternative embodiment, the liquid feed device 100 further includes liquid storage tank 6, institute
It states liquid storage tank 6 and is connected to the liquid chamber 12.The liquid feed device 100 further includes using liquid pool 7, described to connect the liquid with liquid pool 7
Room 12.Under the driving in the first pressure source 4 or the second pressure source 5, the constant displacement pump 1 is extracted in the liquid storage tank 6
Liquid to the liquid chamber 12, the liquid in the liquid chamber 12 is emitted into and described uses liquid pool 7 by the constant displacement pump 1.It is described to use liquid
Pond 7 can be reaction tank or flow chamber.
Optionally, as shown in Figure 1, the first pressure source 4 is stored with dilution in the liquid storage tank 6 for providing positive pressure
Liquid or hemolytic agent.The liquid storage tank 6 is between the first pressure source 4 and first switch piece 2.In the liquid storage tank 6
Form confined space.The constant displacement pump 1 can by the liquid storage tank 6 dilution or hemolytic agent quantitatively input and described use liquid
Pond 7.
It is described generally large with demand of the liquid pool 7 to dilution or hemolytic agent in the sample analyser, therefore,
Under comparable operating conditions, selection drives the constant displacement pump 1 with double positive pressures, and feed flow is more stable, is conducive to improve the feed flow dress
100 liquid supply speed is set, to improve the test speed of the sample analyser.On the other hand, due to the sample analyser
When establishing negative pressure, scope limitation is larger (negative pressure can not subatmospheric 101kPa or more), and the negative pressure for needing to establish is got over
It is low then higher to the hardware requirement of the sample analyser, and the scope limitation of establishing positive pressure is small and hardware requirement is lower, therefore
The constant displacement pump 1 is driven using double positive pressures, is also beneficial to the requirement that lowering apparatus gas circuit builds pressure, lowering apparatus cost.
As a kind of alternative embodiment, as shown in Fig. 2, the first pressure source 4 is for providing negative pressure, the liquid storage tank 6
Inside it is stored with reagent.It is described to use liquid pool 7 between the first pressure source 4 and first switch piece 2.It is described to use liquid pool 7
Interior formation confined space.Reagent quantitative in the liquid storage tank 6 can be inputted the liquid pool 7 by the constant displacement pump 1.
Also referring to Fig. 1 to Fig. 3, as a kind of alternative embodiment, the pressure in the second pressure source 5 and described first
The pressure of pressure source 4 is identical.At this point, the first pressure source 4 and the second pressure source 5 can use same set of pressure source group
Part, and first switch piece 2 and the set pressure source component are connected by the first pipeline 41, it is provided on first pipeline 41
For realizing the first control valve 42 for being connected to and cutting off, pass through the second switch piece of the second pipeline 51 connection 3 and the set pressure source group
Part is provided with for realizing the second control valve 52 for being connected to and cutting off on second pipeline 51.
In the present embodiment, the first pressure source 4 and the second pressure source 5 share a set of pressure source component, favorably
In the cost for reducing the liquid feed device 100.
It is understood that same set of pressure source component can also be used in the 5th pressure source and the 6th pressure source,
Same set of pressure source component can also be used in the third pressure source and the 4th pressure source, and specific setting refers to above-mentioned implementation
Example.
Also referring to Fig. 1 to Fig. 3, as a kind of alternative embodiment, the first pressure source 4 and/or second pressure
Power source 5 includes air pump 81 and air accumulator 82, and the air pump 81 is used in built-in pressure or the negative pressure of attentioning of the air accumulator 82.
The first pressure source 4 and/or the second pressure source 5 are established in the air accumulator 82 by the air pump 81
Positive pressure or negative pressure, then by the power source of positive pressure or negative pressure as the constant displacement pump 1 in the air accumulator 82, so as to
Big flow air pump in the prior art is substituted, the cost and energy consumption of the liquid feed device 100 and the sample analyser are reduced.
Simultaneously as the sample analyser can use the air pump 81 of small size, therefore the sample analyser can be reduced
Machine volume.The study found that using the mode of small size air pump cooperation air accumulator to provide the sample of driving for gas circuit and fluid path
In this analyzer, using it is above-mentioned be all positive pressure or be all negative pressure constant displacement pump driving method, can realize well stablize it is quick
Feed flow.Compared with tradition uses the sample analyser of big flow air pump, performance having the same, but cost can greatly drop
It is low, it has a good application prospect.In particular, in order to realize accurately vacuum cavitations, it is relatively high to hardware requirement, so adopting
With the constant displacement pump driving for being all positive pressure, good performance can be provided and further reduced the cost.
It is understood that in the first embodiment, the first pressure source 4 and the second pressure source 5 are respective
All have the air pump 81 and the air accumulator 82.In the second embodiment, the first pressure source 4 and second pressure
Power source 5 shares a set of air pump 81 and the air accumulator 82.In the third embodiment, the first pressure source 4 includes
The air pump 81 and the air accumulator 82, the second pressure source 5 use other power source structures (such as air pump).At the 4th kind
In embodiment, the second pressure source 5 includes the air pump 81 and the air accumulator 82, and the first pressure source 4 uses it
His power source structure (such as air pump).
As a kind of alternative embodiment, the sample analyser further includes sampling component, reaction component, detection components, gives up
Liquid processing component and controller.The sampling component is for acquiring and distributing biological sample.The sampling component includes sampling
Device, the sampler is for acquiring and distributing biological sample.The reaction component be used for the biological sample handled with
Form prepare liquid.The reaction component includes multiple reaction tanks.The detection components form inspection for detecting the prepare liquid
Measurement information.The detection components include flow chamber.The liquid waste processing component is for collecting and discharging in the sample analyser
Waste liquid.The controller is used to control the workflow of the sample analyser and handles the detection information to form analysis
As a result.
Also referring to Fig. 1 to Fig. 3, the embodiment of the present invention also provides a kind of feed liquid method of liquid feed device 100, the confession
Liquid method can be applied to liquid feed device 100 described in above-described embodiment.
As a kind of alternative embodiment, the liquid feed device 100 includes constant displacement pump 1, first pressure source 4 and second pressure source
5, the constant displacement pump 1 has diaphragm 11 and liquid chamber 12 and gas chamber 13 positioned at 11 two sides of diaphragm, 4 He of first pressure source
The second pressure source 5 is all positive pressure.The feed liquid method of the liquid feed device 100 includes:
It is connected to the liquid chamber 12 and the first pressure source 4, so that the pressure of the liquid chamber 12 is greater than the gas chamber 13
Pressure, the diaphragm 11 is mobile to the gas chamber 13 under differential pressure action, and liquid enters the liquid chamber 12；With
It is connected to the gas chamber 13 and the second pressure source 5, so that the pressure of the gas chamber 13 is greater than the liquid chamber 12
Pressure, the diaphragm 11 is mobile to the liquid chamber 12 under differential pressure action, and the liquid flows out the liquid chamber 12 to carry out feed flow.
In the present embodiment, the constant displacement pump 1 is driven due to the feed liquid method using double positive pressures, is can be avoided
The constant displacement pump 1 needs while relying on positive pressure and the problem of negative pressure is driven and leads to unstable working condition, described quantitative
The stable working state of pump 1 advantageously ensures that the inspection of the sample analyser so that the feed flow of the feed liquid method is in stable condition
Survey the accuracy of result.And when the constant displacement pump 1 is using two-way positive pressure driving method, driving difficulty is small, advantageously reduces institute
The energy consumption in first pressure source 4 and the second pressure source 5 is stated, to reduce the energy consumption of the sample analyser.
Optionally, when being connected to the liquid chamber 12 with the first pressure source 4, the gas chamber 13 is connected to atmosphere or third
Pressure source, the pressure absolute value of the third pressure source are lower than the pressure absolute value in the first pressure source 4.At this point, the liquid
Pressure difference is more prone to produce between room 12 and the gas chamber 13, the first pressure source 4 pushes the diaphragm 11 to the gas chamber
The mobile difficulty in 13 direction is smaller, advantageously reduces the energy consumption in the first pressure source 4, and 1 imbibition of the constant displacement pump movement is difficult
It spends small and stablizes.
Optionally, when being connected to the gas chamber 13 with the second pressure source 5, the liquid chamber 12 is connected to atmosphere or the 4th
Pressure source, the pressure absolute value of the 4th pressure source are lower than the pressure absolute value in the second pressure source 5.At this point, the gas
Pressure difference is more prone to produce between room 13 and the liquid chamber 12, the second pressure source 5 pushes the diaphragm 11 to the liquid chamber
The mobile difficulty in 12 direction is smaller, advantageously reduces the energy consumption in the second pressure source 5, and 1 drain of the constant displacement pump movement is difficult
It spends small and stablizes.
As another alternative embodiment, the liquid feed device 100 includes constant displacement pump 1, first pressure source 4 and second pressure
Source 5, the constant displacement pump 1 have diaphragm 11 and liquid chamber 12 and gas chamber 13 positioned at 11 two sides of diaphragm, the first pressure source 4
It is all negative pressure with the second pressure source 5.The feed liquid method of the liquid feed device 100 includes:
It is connected to the gas chamber 13 and the second pressure source 5, so that the pressure of the liquid chamber 12 is greater than the gas chamber 13
Pressure, the diaphragm 11 is mobile to the gas chamber 13 under differential pressure action, and liquid enters the liquid chamber 12；With
It is connected to the liquid chamber 12 and the first pressure source 4, so that the pressure of the gas chamber 13 is greater than the liquid chamber 12
Pressure, the diaphragm 11 is mobile to the liquid chamber 12 under differential pressure action, and the liquid flows out the liquid chamber 12 to carry out feed flow.
In the present embodiment, the constant displacement pump 1 is driven due to the feed liquid method using double negative pressure, is can be avoided
The constant displacement pump 1 needs while relying on positive pressure and the problem of negative pressure is driven and leads to unstable working condition, described quantitative
The stable working state of pump 1 advantageously ensures that the inspection of the sample analyser so that the feed flow of the feed liquid method is in stable condition
Survey the accuracy of result.
Optionally, when being connected to the liquid chamber 12 with the first pressure source 4, the gas chamber 13 is connected to atmosphere or the 5th
Pressure source, the pressure absolute value of the 5th pressure source are lower than the pressure absolute value in the first pressure source 4.At this point, the gas
Pressure difference is more prone to produce between room 13 and the liquid chamber 12, the second pressure source 5 pushes the diaphragm 11 to the liquid chamber
The mobile difficulty in 12 direction is smaller, advantageously reduces the energy consumption in the second pressure source 5, and 1 drain of the constant displacement pump movement is difficult
It spends small and stablizes.
Optionally, when being connected to the gas chamber 13 with the second pressure source 5, the liquid chamber 12 is connected to atmosphere or the 6th
Pressure source, the pressure absolute value of the 6th pressure source are lower than the pressure absolute value in the second pressure source 5.At this point, the liquid
Pressure difference is more prone to produce between room 12 and the gas chamber 13, the first pressure source 4 pushes the diaphragm 11 to the gas chamber
The mobile difficulty in 13 direction is smaller, advantageously reduces the energy consumption in the first pressure source 4, and 1 imbibition of the constant displacement pump movement is difficult
It spends small and stablizes.
As a kind of alternative embodiment, the first pressure source 4 and/or the second pressure source 5 include air accumulator 82.Institute
It states building for air pressure in air accumulator 82 and presses through journey are as follows:
The pressure that pressure absolute value is greater than preset value is established in the air accumulator 82；With
The air accumulator 82 is connected to atmosphere, the pressure absolute value of the pressure is made to be reduced to the preset value.
In the present embodiment, pressure absolute value is first established in the air accumulator 82 due to the air pump 81 greater than preset value
The pressure, therefore even if occur overshooting and rebound phenomenon, the pressure absolute value of the pressure still are able to be remained above described
The state of preset value is reduced to the pressure absolute value of the pressure described default
Value, so that the pressure has accurate pressure value after completion builds and presses through journey.In short, above-mentioned build presses through journey and can eliminate
Two kinds of phenomenons of overshoot and rebound, realize and accurately build pressure.
It will be appreciated by those skilled in the art that being used in constant displacement pump with respect to the chamber of the other side of liquid chamber in the present embodiment
Gas filling and driving, therefore referred to as gas chamber.This cavity is substantially to rise during the liquid chamber of constant displacement pump passes in and out liquid with cooperation
Chamber can also fill other media such as liquid.
The embodiment of the present invention has been described in detail above, specific case used herein to the principle of the present invention and
Embodiment is expounded, and the above description of the embodiment is only used to help understand the method for the present invention and its core ideas；
At the same time, for those skilled in the art can in specific embodiments and applications according to the thought of the present invention
There is change place, in conclusion the contents of this specification are not to be construed as limiting the invention.
Claims (16)
1. a kind of agent delivery device, which is characterized in that including constant displacement pump, the first switch piece, first pressure source and the second pressure
Power source, liquid chamber and cooperation room, first switch piece of the constant displacement pump with diaphragm and positioned at the diaphragm two sides are connected to
Between the liquid chamber and the first pressure source, pressure of the first pressure source for changing the liquid chamber, second pressure
Power source connects the cooperation room and provides pressure for it, by the pressure difference between the liquid chamber and the cooperation room it is mobile described in every
Film, the first pressure source and the second pressure source are all positive pressure or are all negative pressure.
2. agent delivery device as described in claim 1, which is characterized in that first switch piece be also connected to atmosphere or
4th pressure source, the pressure absolute value of the 4th pressure source are lower than the pressure absolute value in the second pressure source；Described 4th
Pressure source provides negative pressure.
3. agent delivery device as described in claim 1, which is characterized in that first switch piece is also connected to atmosphere or
Six pressure sources, the pressure absolute value of the 6th pressure source are lower than the pressure absolute value in the second pressure source；6th pressure
Power source provides positive pressure.
4. agent delivery device as described in any one of claims 1-3, which is characterized in that the agent delivery device further includes
Liquid storage tank, the liquid storage tank are connected to the liquid chamber.
5. agent delivery device according to any one of claims 1-4, which is characterized in that agent delivery device further includes liquid storage
Portion and with liquid portion；When first pressure source and the second pressure source are all positive pressure, first switch piece is connected by liquid storing part
Connect the first pressure source；When first pressure source and the second pressure source are all negative pressure, first switch piece passes through use
Liquid portion connects the first pressure source.
6. agent delivery device as described in any one in claim 1-5, which is characterized in that the pressure in the second pressure source with
The pressure in the first pressure source is different.
7. agent delivery device as claimed in any one of claims 1 to 6, which is characterized in that cut in the first pressure source and first
Change the pressure that part changes the liquid chamber.
8. a kind of sample analyser characterized by comprising
Sampling component has sampler, the samplers sample and distribution sample；
Reaction component, has at least one reaction tank, and the sampler distributes the sample into reaction tank, prepares prepare liquid；
Agent delivery device, including constant displacement pump, the first switch piece, first pressure source and second pressure source, the constant displacement pump tool
There are diaphragm and liquid chamber and cooperation room positioned at the diaphragm two sides, first switch piece is connected to the liquid chamber and described first
Between pressure source, the first pressure source and the first switch piece change the pressure of the liquid chamber, and the second pressure source connects institute
It states cooperation room and for it provides pressure, by the mobile diaphragm of pressure difference between the liquid chamber and the cooperation room, described the
One pressure source and the second pressure source are all positive pressure or are all negative pressure, the first pressure source and/or the second pressure source
Including air pump and air accumulator, the air pump is in built-in pressure or the negative pressure of attentioning of the air accumulator；
Detection components have flow chamber, and the prepare liquid flows through the flow chamber, obtain detection information；With
Controller is coupled with the sampling component, reaction component, agent delivery device, detection components, is controlled it and is acted and handle
The detection information obtains analysis result.
9. sample analyser as claimed in claim 8, which is characterized in that the first pressure source is negative pressure, first pressure
Power source provides negative pressure by reaction tank for the liquid chamber.
10. sample analyser as claimed in claim 8, which is characterized in that the sample analyser further includes liquid storage tank, described
Liquid storage tank is connected to the liquid chamber.
11. sample analyser as claimed in claim 10, which is characterized in that the first pressure source be positive pressure, described first
Pressure source provides positive pressure by the liquid storage tank for the liquid chamber.
12. a kind of agent delivery method of sample analyser, which is characterized in that the sample analyser includes constant displacement pump, and first
Pressure source and second pressure source, the constant displacement pump have diaphragm and a liquid chamber and cooperation room positioned at the diaphragm two sides, and described the
One pressure source and the second pressure source are all positive pressure, which comprises
Cooperation room and the second pressure source described in continual communication；It is connected to the liquid chamber and the first pressure source, so that described
The pressure of liquid chamber is greater than the pressure of the cooperation room, and the diaphragm is mobile to room joined together under differential pressure action, and liquid enters institute
State liquid chamber；The liquid chamber and the first pressure source are disconnected, so that the pressure of the cooperation room is greater than the pressure of the liquid chamber, institute
It is mobile to the liquid chamber under differential pressure action to state diaphragm, the liquid flows out the liquid chamber to carry out feed flow.
13. agent delivery method as claimed in claim 12, which is characterized in that the liquid chamber is also connected to atmosphere or the 4th
Pressure source, the pressure absolute value of the 4th pressure source are lower than the pressure absolute value in the second pressure source；Preferably, described
Four pressure sources provide negative pressure.
14. a kind of agent delivery method of sample analyser, which is characterized in that the sample analyser includes constant displacement pump, first
Pressure source and second pressure source, the constant displacement pump have diaphragm and a liquid chamber and cooperation room positioned at the diaphragm two sides, and described the
One pressure source and the second pressure source are all negative pressure, and the agent delivery method includes:
Cooperation room and the second pressure source described in continual communication；The liquid chamber and the first pressure source are disconnected, so that described
The pressure of liquid chamber is greater than the pressure of the cooperation room, and the diaphragm is mobile to room joined together under differential pressure action, and liquid enters institute
State liquid chamber；It is connected to the liquid chamber and the first pressure source, so that the pressure of the cooperation room is greater than the pressure of the liquid chamber, institute
It is mobile to the liquid chamber under differential pressure action to state diaphragm, the liquid flows out the liquid chamber to carry out feed flow.
15. agent delivery method as claimed in claim 14, which is characterized in that the liquid chamber is also connected to atmosphere or the 6th
Pressure source, the pressure absolute value of the 6th pressure source are lower than the pressure absolute value in the second pressure source；Preferably, described
Six pressure sources provide positive pressure.
16. such as the described in any item agent delivery methods of claim 12~15, which is characterized in that the first pressure source and/
Or the second pressure source includes air accumulator, building for air pressure presses through journey in the air accumulator are as follows:
The pressure that pressure absolute value is greater than preset value is established in the air accumulator；With
The air accumulator is connected to atmosphere, the pressure absolute value of the pressure is made to be reduced to the preset value.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201910310887.7A CN110031644A (en) | 2017-06-30 | 2017-06-30 | Agent delivery device, sample analyser and agent delivery method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910310887.7A CN110031644A (en) | 2017-06-30 | 2017-06-30 | Agent delivery device, sample analyser and agent delivery method |
| CN201710532475.9A CN109212247A (en) | 2017-06-30 | 2017-06-30 | The feed liquid method of liquid feed device, sample analyser and liquid feed device |
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| CN201710532475.9A Division CN109212247A (en) | 2017-06-30 | 2017-06-30 | The feed liquid method of liquid feed device, sample analyser and liquid feed device |
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| CN110031644A true CN110031644A (en) | 2019-07-19 |
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| CN201710532475.9A Pending CN109212247A (en) | 2017-06-30 | 2017-06-30 | The feed liquid method of liquid feed device, sample analyser and liquid feed device |
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| CN114460326A (en) * | 2022-04-11 | 2022-05-10 | 深圳市帝迈生物技术有限公司 | Reagent replenishing device and reagent replenishing method for sample analyzer |
| WO2023207208A1 (en) * | 2022-04-24 | 2023-11-02 | 深圳市帝迈生物技术有限公司 | Sample analyzer and pressure buildup control method therefor |
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| CN112857949A (en) * | 2019-11-12 | 2021-05-28 | 深圳迈瑞生物医疗电子股份有限公司 | Liquid discharging method of quantitative device, dye liquid preparation method and computer storage medium |
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| CN109212247A (en) | 2019-01-15 |
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