CN114527055A - Sample analyzer, liquid path system thereof and pressure building control method - Google Patents
Sample analyzer, liquid path system thereof and pressure building control method Download PDFInfo
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- 239000007788 liquid Substances 0.000 title claims abstract description 90
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- 238000001514 detection method Methods 0.000 claims abstract description 39
- 239000012530 fluid Substances 0.000 claims description 52
- 238000005086 pumping Methods 0.000 claims description 29
- 239000003085 diluting agent Substances 0.000 claims description 16
- 230000006837 decompression Effects 0.000 claims description 10
- 239000002699 waste material Substances 0.000 claims description 9
- 210000004027 cell Anatomy 0.000 description 102
- 239000000523 sample Substances 0.000 description 64
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- 238000004140 cleaning Methods 0.000 description 9
- 238000001914 filtration Methods 0.000 description 6
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- 210000000601 blood cell Anatomy 0.000 description 4
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- 210000002421 cell wall Anatomy 0.000 description 2
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- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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Abstract
The embodiment of the application provides a liquid path system of a sample analyzer, a pressure building control method and a sample analyzer, which comprise a gas storage device, a pressure source and a counting cell which are connected with the gas storage device, a pressure building passage which is connected between the gas storage device and the pressure source, a pressure detection element which is connected with the gas storage device and a control device; the control equipment is connected with the pressure building passage and the pressure detection element; when the counting cell is in a preset state, the control equipment controls the pressure building passage to be opened, and the pressure source builds pressure on the gas storage device; when the current pressure value in the gas storage device reaches a first preset pressure value, the control equipment controls the pressure building passage to be closed, and controls the current pressure value of the gas storage device to be adjusted to a second preset pressure value within a first preset time range; and the absolute value of the first preset pressure value is greater than the absolute value of the second preset pressure value.
Description
Technical Field
The application relates to the technical field of medical instruments, in particular to a sample analyzer, a liquid path system of the sample analyzer and a pressure building control method applied to the liquid path system of the sample analyzer.
Background
With the popularization of the application of the blood cell analyzer, the requirements on the accuracy and precision of the detection result of the blood cell analyzer are higher and higher. The electrical impedance method is the mainstream methodology of blood cell detection and counting, and the blood cells are counted and classified mainly by counting the electric signal change caused when the cells in a sample liquid pass through a small hole, and the power source of the electrical impedance method is the negative pressure established by an internal pump of the instrument.
The currently common pressure build-up method is relatively extensive, and as shown in fig. 1, the gas storage device 101 is directly connected to the pressure source 102. The gas storage device 101 is a gas tank, the pressure source 103 is a gas pump, generally, one pump is connected with one gas tank, the gas pump is started to build pressure, and when the pressure reaches a certain range, the gas pump is closed. There are two problems with this pressure build-up approach: (1) the pressure build-up of the air pump is too fast, and the pressure is overshot, so that the pressure build-up is inaccurate or false alarm is caused; (2) the short time pressure change in the gas pitcher, the internal pressure of gas pitcher is unbalanced, and after the air pump was closed, pressure has a process of rebalancing again, leads to building the pressure inaccurate.
Disclosure of Invention
In order to solve the existing technical problems, the application provides a sample analyzer capable of accurately achieving a target pressure value in a pressure building process, a liquid path system of the sample analyzer, and a pressure building control method applied to the liquid path system in the sample analyzer.
In order to achieve the above purpose, the technical solution of the embodiment of the present application is implemented as follows:
a liquid path system of a sample analyzer comprises a gas storage device, a pressure source and a counting cell which are connected with the gas storage device, a pressure building passage connected between the gas storage device and the pressure source, a pressure detection element connected with the gas storage device and a control device; the control equipment is connected with the negative pressure passage and the pressure detection element; the pressure detection element is used for detecting the current pressure value in the gas storage device; when the counting cell is in a preset state, the control equipment controls the pressure building passage to be opened and the pressure relief passage to be closed, and the pressure source builds pressure on the gas storage device; when the current pressure value in the gas storage device reaches a first preset pressure value, the control equipment controls the pressure building passage to be closed, and controls the current pressure value of the gas storage device to be adjusted to a second preset pressure value within a first preset time range; and the absolute value of the first preset pressure value is greater than the absolute value of the second preset pressure value.
Optionally, the pressure building path includes a negative pressure path, the fluid path system further includes a pressure relief path and a timer, and the control device is connected to the negative pressure path, the pressure relief path, the timer and the pressure detection element; when the counting cell is started for counting, the control equipment controls the negative pressure passage to be opened and the pressure relief passage to be closed, and the pressure source establishes negative pressure on the gas storage device; when the current pressure value in the gas storage device reaches a first preset pressure value, the control equipment controls the negative pressure passage to be closed, controls the timer to start timing, and controls the pressure relief passage to be opened when the reading of the timer reaches a first preset time length; the gas storage device is decompressed through the decompression passage, when the current pressure value in the gas storage device reaches a second preset pressure value, the control device controls the decompression passage to be closed, and the counting cell executes a counting process.
Optionally, the pressure building path includes a positive pressure path, the fluid path system further includes a pressure relief path and a timer, and the control device is connected to the positive pressure path, the pressure relief path, the timer and the pressure detection element; when the counting pool stops counting, the control equipment controls the positive pressure passage to be opened, the negative pressure passage and the pressure relief passage to be closed, and the pressure source establishes positive pressure on the gas storage device; when the current pressure value in the gas storage device reaches a first preset pressure value, the control equipment controls the positive pressure passage to be closed and controls the timer to start timing, and when the reading of the timer reaches a second preset time length, the pressure relief passage is controlled to be opened; the gas storage device carries out pressure relief through the pressure relief passage, when the current pressure value in the gas storage device reaches a second preset pressure value, the control equipment controls the pressure relief passage to be closed, and the gas storage device executes a waste liquid discharge flow.
Optionally, the liquid path system of the sample analyzer further includes a first liquid pumping path connected between the counting cell and the gas storage device, in the process of executing the counting process by the counting cell, the control device controls the first liquid pumping path to be opened, the gas storage device pumps the sample liquid to be detected in the counting cell to the gas storage device through the current pressure in the gas storage device and the first liquid pumping path, and the control device determines the count value of the cells in the sample liquid to be detected according to a level signal generated when the cells in the sample liquid to be detected are filtered.
Optionally, the liquid path system of the sample analyzer further includes a second liquid pumping path connected between the counting cell and the gas storage device, when the counting cell completes the counting process, the control device controls the second liquid pumping path to be opened, and the gas storage device pumps the remaining sample liquid to be detected in the counting cell into the gas storage device through the second liquid pumping path.
Optionally, the liquid way system of sample analysis appearance is still including connecting a plurality of liquid feeding passageways between tally pond and the diluent, works as when the tally pond is accomplished the count flow, controlgear control a plurality of liquid feeding passageways are opened simultaneously, the diluent passes through a plurality of liquid feeding passageways fill to in the tally pond.
Optionally, the fluid path system of the sample analyzer further includes a flow limiting element, and the flow limiting element is connected to the gas storage device through the pressure relief passage; the flow limiting piece is used for adjusting the pressure relief flow of the gas storage device.
Optionally, an embodiment of the present application further provides a pressure buildup control method for a fluid path system including the sample analyzer in any one of the foregoing embodiments, which is applied to a control device, and includes: controlling the pressure building passage to be opened according to the received trigger signal; receiving the current pressure value in the gas storage device detected by the pressure detection element, controlling the pressure building passage to be closed when the current pressure value in the gas storage device reaches a first preset pressure value, and controlling the current pressure value of the gas storage device to be adjusted to a second preset pressure value within a first preset time range; and the absolute value of the first preset pressure value is greater than the absolute value of the second preset pressure value.
Optionally, the pressure building path includes a negative pressure path, the fluid path system further includes a pressure relief path and a timer, and the control device is connected to the negative pressure path, the pressure relief path, the timer and the pressure detection element; when the counting cell is started for counting, the control equipment controls the negative pressure passage to be opened and the pressure relief passage to be closed so that the pressure source can establish negative pressure on the gas storage device; when the current pressure value obtained in the gas storage device reaches a first preset pressure value, controlling the pressure building passage to be closed, and controlling the current pressure value of the gas storage device to be adjusted to a second preset pressure value within a first preset time range comprises: when the current pressure value in the air storage device reaches a first preset pressure value, the negative pressure passage is controlled to be closed, a timer is controlled to start timing, and the pressure relief passage is controlled to be opened when the reading of the timer reaches a first preset time length; and when the current pressure value in the gas storage device reaches a second preset pressure value, the control equipment controls the pressure relief passage to be closed.
Optionally, the pressure building path includes a positive pressure path, the fluid path system further includes a pressure relief path and a timer, and the control device is connected to the positive pressure path, the pressure relief path, the timer and the pressure detection element; when the counting pool stops counting, the control equipment controls the positive pressure passage to be opened and the pressure relief passage to be closed so that the pressure source can establish positive pressure on the gas storage device; when the current pressure value obtained in the gas storage device reaches a first preset pressure value, controlling the pressure building passage to be closed, and controlling the current pressure value of the gas storage device to be adjusted to a second preset pressure value within a first preset time range comprises: when the current pressure value in the gas storage device is obtained and reaches a first preset pressure value, the positive pressure passage is controlled to be closed, a timer is controlled to start timing, and the pressure relief passage is controlled to be opened when the reading of the timer reaches a second preset time length; and when the current pressure value in the gas storage device reaches a second preset pressure value, the control equipment controls the pressure relief passage to be closed.
Optionally, an embodiment of the present application further provides a sample analyzer, including the liquid path system of the sample analyzer in any one of the above embodiments.
In the liquid path system of the sample analyzer provided in the above embodiment of the present application, when the counting cell is in a preset state, the control device controls the pressure building path to open, and the pressure source builds pressure on the gas storage device; when the current pressure value in the gas storage device reaches a first preset pressure value, the control equipment controls the pressure regulating passage to be closed, and controls the current pressure value of the gas storage device to be regulated to a second preset pressure value within a first preset time range. Therefore, the liquid path system of the sample analyzer can enable the air pressure in the air storage device to be rebalanced within a certain time after the air pressure is built quickly, so that the air pressure in the air storage device can reach a second preset pressure value more stably and accurately, and the condition that the air pressure in the air storage device is inaccurate in pressure building due to the fact that the pressure rebalancing occurs after the pressure source is closed is effectively avoided.
The pressure build-up control method, the sample analyzer and the liquid path system applied to the liquid path system comprise the same specific technical characteristics, have the same beneficial technical effects as the liquid path system, and are not described herein again.
Drawings
FIG. 1 is a schematic diagram of a prior art connection between a pressure source and a gas storage device;
FIG. 2 is a schematic diagram of a fluid path system of a sample analyzer according to an embodiment of the present disclosure;
FIG. 3 is a circuit diagram of devices in a fluid path system of a sample analyzer according to an embodiment of the present disclosure;
fig. 4 is a flowchart of a pressure build-up control method applied to a control device in a fluid path system of a sample analyzer according to an embodiment of the present disclosure;
FIG. 5 is a graph illustrating the pressure change in the gas storage device when the control device controls the pressure source to create negative pressure in the gas storage device according to the prior art;
FIG. 6 is a graph illustrating the pressure change in the gas storage device after the control device controls the pressure source to create negative pressure in the gas storage device according to the embodiment of the present disclosure;
FIG. 7 is a graph illustrating the pressure change in the gas storage device when the control device controls the pressure source to create positive pressure in the gas storage device according to an embodiment of the present disclosure;
fig. 8 is a specific flowchart illustrating the operation of the control device controlling each device in the fluid path system of the sample analyzer according to an embodiment of the present disclosure.
Detailed Description
The technical solution of the present application is further described in detail with reference to the drawings and specific embodiments of the specification.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used herein in the description of the present application is for the purpose of describing particular embodiments only and is not intended to be limiting of implementations of the present application. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
In the description of the present application, it is to be understood that the terms "center", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience in describing the present application and simplifying the description, but do not indicate or imply that the referred device or element must have a particular orientation, be constructed in a particular orientation, and be operated, and thus should not be construed as limiting the present application. In the description of the present application, "a plurality" means two or more unless otherwise specified.
In the description of the present application, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present application can be understood by those of ordinary skill in the art as appropriate.
Referring to fig. 2 and fig. 3, fig. 2 is a schematic structural diagram of a fluid path system of a sample analyzer according to an embodiment of the present disclosure, and fig. 3 is a circuit connection diagram of each device in the fluid path system of the sample analyzer according to the embodiment of the present disclosure. The liquid path system of the sample analyzer comprises a gas storage device 101, a pressure source 102 and a counting cell 103 which are connected with the gas storage device 101, a pressure building passage connected between the gas storage device 101 and the pressure source 102, a pressure detection element 106 connected with the gas storage device 101 and a control device 107; the control device 107 is connected with the pressure building passage and the pressure detection element 106; when the counting cell 103 is in a preset state, the control device 107 controls the pressure building passage to be opened, and the pressure source 102 builds pressure on the gas storage device 101; when the current pressure value in the gas storage device 101 reaches a first preset pressure value, the control device 107 controls the pressure building passage to be closed, and controls the current pressure value of the gas storage device 101 to be adjusted to a second preset pressure value within a first preset time range; and the absolute value of the first preset pressure value is greater than the absolute value of the second preset pressure value.
Here, the gas storage device 101 is used to provide a pressure building site, and may be a gas storage tank or the like. The pressure source 102 is used to establish negative or positive pressure in the gas storage device 101, and may be a gas pump or the like. The pressure buildup circuit may include a negative pressure circuit 104 and a positive pressure circuit 105, the negative pressure circuit 104 is used for the pressure source 102 to establish negative pressure for the gas storage device 101, and the positive pressure circuit 105 is used for the pressure source 102 to establish positive pressure for the gas storage device 101. In some embodiments, the counting cell 103 may be an impedance detection counting cell. The counting cell 103 is used for providing a cell counting place for the sample liquid to be detected, and comprises a front cell, a rear cell and a cell filtering component positioned between the front cell and the rear cell. The front pool is used for containing sample liquid to be detected, the sample liquid to be detected flows to the rear pool through the filtering component under the negative pressure action of the gas storage device 101, wherein when each cell in the sample liquid to be detected passes through the small hole of the filtering component, a corresponding level signal is generated, and the counter 103 transmits the change condition of the level signal to the control device 107, so that the counting of the cells in the sample liquid to be detected is realized. The negative pressure in the gas storage device 101 is mainly used for driving the sample liquid to be detected in the counting cell 103 to flow from the front cell to the rear cell through the filtering component. The positive pressure in the gas storage device 101 is mainly used for the gas storage device 103 to execute a waste liquid discharge process. The control device 107 may be a programmable controller, such as a PLC controller, a single chip controller, a computer host CPU controller, etc. The pressure detecting element 106 may be a pressure detector or a pressure sensor. The first preset pressure value may be an initial pressure value when the pressure source 102 builds pressure on the gas storage device 101. The second preset pressure value may be a target pressure value for pressurizing the gas storage device 101. In this embodiment of the present application, an absolute value of the first preset pressure value is higher than an absolute value of the second preset pressure value. In the embodiment of the present application, when the counting cell 103 is in the preset state, the control device 107 controls the pressure building passage to open, and the pressure source 102 builds pressure on the gas storage device 101; when the current pressure value in the gas storage device 101 reaches the first preset pressure value, the control device 107 controls the pressure regulating passage to be closed, and controls the current pressure value of the gas storage device 101 to be regulated to the second preset pressure value within the first preset time range. Therefore, the liquid path system of the sample analyzer can enable the air pressure in the air storage device 101 to be rebalanced within a certain time after the air pressure is built quickly, so that the air pressure in the air storage device can reach a target pressure value more stably and accurately, and the condition that the pressure is built inaccurately due to the fact that the pressure is rebalanced after the pressure source is closed is effectively avoided.
In some embodiments, the pressure building path includes a negative pressure path 104, the fluid path system further includes a pressure relief path 105 and a timer 112, and the control device 107 is connected to the negative pressure path 104, the pressure relief path 105, the timer 112 and the pressure detection element 106; when the counting cell 112 is started for counting, the control device 107 controls the negative pressure passage 104 to be opened and the pressure relief passage 105 to be closed, and the pressure source 102 establishes a negative pressure for the gas storage device 101; when the current pressure value in the gas storage device 101 reaches a first preset pressure value, the control device 107 controls the negative pressure passage 104 to be closed, controls the timer 112 to start timing, and controls the pressure relief passage 105 to be opened when the reading of the timer 112 reaches the first preset time length; the gas storage device 101 is decompressed through the decompression passage 105, when the current pressure value in the gas storage device 101 reaches a second preset pressure value, the control device 107 controls the decompression passage 105 to be closed, and the counting cell 103 executes a counting process.
Here, the negative pressure passage 104 includes a first control valve 1041, and the first control valve 1041 is connected to the control device 107. The control device 107 controls the first control valve 1041 to connect or cut off the passage between the pressure source 102 and the gas storage device 101 when the pressure source 102 establishes a negative pressure to the gas storage device 101. The pressure relief passage 105 includes a second control valve 1051, and the second control valve 1051 is connected to the control device 107. When the control device 107 controls the second control valve 1051 to release the pressure of the gas storage device 101, the passage between the gas storage device 101 and the atmosphere is connected or cut off. The negative pressure in the gas storage device 101 is mainly used for providing stable negative pressure for the counting cell 103. The timer 112 is configured to record a stop duration after a current pressure value in the gas storage device 101 reaches a first preset pressure value. The first preset time period may be a pause time period, for example, 0.5S, preset in the control device 107 for controlling the gas storage device 101 after the negative pressure is established. Here, the first preset pressure value may refer to an initial pressure value when the pressure source 102 establishes a negative pressure on the gas storage device 101. The second preset pressure value may be a target pressure value for establishing negative pressure on the gas storage device 101.
In the embodiment of the application, when the negative pressure in the gas storage device 101 reaches the first preset value, by setting the pause time of the first preset time, it can be ensured that the negative pressure in the gas storage device 101 has enough time to rebalance, and the problem of inaccurate pressure in the gas storage device 101 caused by too fast pressurization of the pressure source 102 in the prior art is effectively solved, so that the air pressure in the gas storage device 101 can reach the target pressure value more stably and more accurately. Further, when the counting cell 103 executes a counting process, the gas storage device 101 can provide negative pressure with higher accuracy and better stability. In some embodiments, the pressure building path includes a positive pressure path 108, the fluid path system further includes a pressure relief path 105 and a timer 112, and the control device 107 is connected to the positive pressure path 108, the pressure relief path 105, the timer 112 and the pressure detection element 106; when the counting cell 103 stops counting, the control device 107 controls the positive pressure passage 108 to be opened and the pressure relief passage 105 to be closed, and the pressure source 102 establishes positive pressure to the gas storage device 101; when the current pressure value in the gas storage device 101 reaches a first preset pressure value, the control device 107 controls the positive pressure passage 108 to be closed and controls the timer 112 to start timing, and when the reading of the timer 112 reaches a second preset duration, the pressure relief passage 105 is controlled to be opened; the gas storage device 101 is decompressed through the decompression passage 105, when the current pressure value in the gas storage device 101 reaches a second preset pressure value, the control device 107 controls the decompression passage 105 to be closed, and the gas storage device 101 executes a waste liquid discharge process.
Here, the positive pressure passage 108 includes a third control valve 1081, and the third control valve 1081 is connected to the control apparatus 107. The control device 107 controls the third control valve 1081 to connect or disconnect the passage between the pressure source 102 and the gas storage device 101 when the pressure source 102 establishes positive pressure to the gas storage device 101. The positive pressure is mainly used to discharge the stored waste liquid in the gas storage device 101. Here, the first preset pressure value may refer to an initial pressure value when the pressure source 102 establishes positive pressure on the gas storage device 101. The second preset pressure value may be a target pressure value for establishing positive pressure on the gas storage device 101. The stop of counting in the counting chamber 103 may refer to the completion of counting of the cells in the sample solution to be detected in the counting chamber 103. The second preset time period may be a pause time period preset in the control device 107 for controlling the gas storage device 101 after the positive pressure is established.
In the embodiment of the application, when the positive pressure in the gas storage device 101 reaches the first preset value, the second preset time is set to ensure that the positive pressure in the gas storage device 101 has enough time to rebalance, so that the problem of inaccurate pressure in the gas storage device 101 caused by too fast pressurization of the pressure source 102 in the prior art is effectively solved, and the air pressure in the gas storage device 101 can reach the target pressure value more stably and more accurately. Further, when the gas storage device 101 executes the waste liquid discharge process, the waste liquid in the gas storage device can be effectively discharged thoroughly at one time.
In some other embodiments, the counting cell 103 may be an optical detection counting cell. By establishing positive pressure in the gas storage device 101, under the action of the positive pressure provided by the gas storage device 101, the sheath fluid is pushed to enter the flow chamber of the optical detection counting cell, and the sample fluid to be detected entering the flow chamber is driven by the sheath fluid to be detected and counted in the optical detection counting cell by an optical detection method. The pressure building passage comprises a positive pressure passage, the liquid path system further comprises a pressure relief passage and a timer, and the control equipment is connected with the positive pressure passage, the pressure relief passage, the timer and the pressure detection element; when the counting cell is started to count, the control equipment controls the positive pressure passage to be opened and the pressure relief passage to be closed, and the pressure source establishes positive pressure on the gas storage device; when the current pressure value in the gas storage device reaches a first preset pressure value, the control equipment controls the positive pressure passage to be closed and controls the timer to start timing, and when the reading of the timer reaches a third preset time length, the pressure relief passage is controlled to be opened; the gas storage device is decompressed through the decompression passage, when the current pressure value in the gas storage device reaches a second preset pressure value, the control device controls the decompression passage to be closed, and the counting cell executes a counting process.
In some embodiments, the fluid path system of the sample analyzer further includes a first fluid pumping path 109 connected between the counting cell 103 and the gas storage device 101, during the counting process performed by the counting cell 103, the control device 107 controls the first fluid pumping path 109 to open, the gas storage device 101 pumps the sample fluid to be measured in the counting cell 103 into the gas storage device 101 through the current pressure in the gas storage device and the first fluid pumping path 109, and the control device 107 determines the count value of the cells in the sample fluid to be measured according to a level signal generated when the cells in the sample fluid to be measured are filtered.
Here, the first pumping channel 109 includes a fourth control valve 1091, and the fourth control valve 1091 is connected to the control device 107. The control device 107 controls the fourth control valve 1091 to connect or disconnect the passage between the gas storage device 101 and the counting cell 103 when the gas storage device 101 supplies negative pressure to the counting cell 103. In the process that the counting cell 103 executes the counting process, the controlling device 107 controls the first liquid pumping passage 109 to open, and the gas storage device 101 pumps the sample liquid to be detected in the counting cell 103 into the gas storage device 101 through the first liquid pumping passage 109 may refer to: after the counting flow of the counting cell 103 is started, the control device 107 controls the fourth control valve 1091 to be opened, and because the inside of the gas storage device 101 is in a negative pressure state at this time, the sample liquid to be measured in the counting cell 103, which is located in the front cell, flows to the rear cell through the filtering component under the action of the negative pressure in the gas storage device 101, and flows from the rear cell to the inside of the gas storage device 101 through the first liquid pumping passage 109. The determining, by the control device 107, the count value of the cells in the sample solution to be tested according to the level signal generated when the cells in the sample solution to be tested are filtered may be: each cell in the sample liquid to be detected generates a corresponding level signal when passing through the small hole of the filter assembly, the counter 103 transmits the change condition of the level signal to the control device 107, and the control device 107 determines the count value of the cell in the sample liquid to be detected according to the change condition of the level signal.
In this embodiment, the gas storage device 101 provides stable negative pressure for the counting cell 103 through the first liquid pumping passage 109, so as to ensure that the cell counting process of the sample liquid to be detected in the counting cell is performed stably, and the numerical accuracy of the cell counting performed in the counting cell 103 and acquired by the control device 107 is effectively ensured.
In some embodiments, the fluid path system of the sample analyzer further includes a second fluid pumping path 110 connected between the counting cell 103 and the gas storage device 101, when the counting cell 103 completes a counting procedure, the control device 101 controls the second fluid pumping path 110 to open, and the gas storage device 101 pumps the remaining sample fluid to be measured in the counting cell 103 into the gas storage device through the second fluid pumping path 110.
Here, the second pumping path 110 includes a fifth control valve 1101, and the fifth control valve 1101 is connected to the control device 107. The control device 107 controls the fifth control valve 1101 to connect or disconnect the passage between the gas storage device 101 and the counting cell 103. When the counting chamber 103 completes the counting process, the control device 107 immediately controls the fifth control valve 1101 to communicate with the passage between the gas storage device 101 and the counting chamber 103, and at this time, under the action of the negative pressure provided by the gas storage device 101, the remaining sample liquid to be detected in the counting chamber 103 is extracted into the gas storage device 101 through the second liquid extraction passage 110, where the negative pressure provided by the gas storage device 101 may be the residual negative pressure in the gas storage device 101 after the counting performed by the counting chamber 103, or the negative pressure re-established by the gas storage device 101 through the negative pressure passage 104 under the control of the control device 107.
In the embodiment of the application, the second liquid pumping passage 110 is arranged between the counting cell 103 and the gas storage device 101, so that the residual sample liquid to be detected in the counting cell 103 can be removed, and the recycling of the counting cell 103 is ensured; meanwhile, the stable negative pressure in the gas storage device 101 can also enhance the complete removal of the sample liquid to be detected in the counting cell 103.
In some embodiments, the fluid path system of the sample analyzer further includes a plurality of fluid feeding paths 111 connected between the counting chamber 103 and the diluent, and when the counting chamber 103 completes the counting process, the control device 107 controls the plurality of fluid feeding paths 111 to be opened simultaneously, and the diluent is poured into the counting chamber through the plurality of fluid feeding paths 111.
Here, the charging passage 111 includes a sixth control valve 1111, and the sixth control valve 1111 is connected to the control device 107. The control device 107 controls the sixth control valve 1111 to communicate or block the passage between the diluent and the counter reservoir 103. The diluent is used for cleaning the counting cell 103. After the counting tank 103 finishes the counting process, the control device 107 controls the liquid adding passages 111 to be opened simultaneously, and the diluent is respectively filled into the front tank and the rear tank of the counting tank 103 through the liquid adding passages 111 and is used for respectively cleaning the front tank and the rear tank of the counting tank 103.
In the embodiment of the application, the counting cell 103 is cleaned through the plurality of liquid adding passages 111, firstly, the plurality of liquid adding passages 111 can wash the counting cell 103 at multiple angles, so that the diluent collides with the cell wall of the counting cell 103 at multiple angles, the sample liquid to be detected attached to the cell wall in the counting cell 103 can be cleaned, and the recycling of the counting cell 103 is guaranteed; secondly, a plurality of liquid feeding passages 111 can backflush the small holes used for filtering cells in the counting cell 103, namely, the small holes are flushed from the rear cell to the front cell, so that the cleaning effect on the counting cell 103 is improved.
Optionally, when the diluent fills the counting cell 103 for cleaning, the control device 107 controls the fourth control valve and the fifth control valve to open, that is, the control device 107 controls the communication between the first liquid pumping channel 108 and the second liquid pumping channel 109, so that the diluent for cleaning the front cell is pumped into the gas storage device 101 through the second liquid pumping channel 109 under the negative pressure action of the gas storage device 101, and the diluent for cleaning the rear cell is pumped into the gas storage device 101 through the first liquid pumping channel 108 under the negative pressure action of the gas storage device 101. Thus, the cleaning and the recycling of the counting cell 103 are ensured.
In some embodiments, the fluid path system of the sample analyzer further comprises a timer 112, the timer 112 being connected to the control device 107; when the current pressure value in the gas storage device 101 reaches a first preset pressure value, the control device 107 controls to start the timer 112 to start timing, and when the reading of the timer 112 reaches the first preset duration, the pressure relief passage 105 is controlled to be opened.
Here, the timer 112 is used for recording the stop time length after the current pressure value in the gas storage device 101 reaches the first preset pressure value. The first preset time period may be a value preset in the control device 107.
In the embodiment of the application, when the negative pressure in the gas storage device 101 reaches the first preset value, by setting the pause time of the first preset time, it can be ensured that the negative pressure in the gas storage device 101 has enough time to tend to be stable and rebalance, and the problem of inaccurate pressure in the gas storage device 101 caused by too fast pressurization of the pressure source 102 in the prior art is effectively solved, so that the air pressure in the gas storage device 101 can reach the target pressure value more stably and more accurately. Further, when the counting cell 103 executes a counting process, the gas storage device 101 can provide negative pressure with higher accuracy and better stability.
In some embodiments, the fluid path system of the sample analyzer further includes a flow restriction 113, and the flow restriction 113 is connected to the gas storage device 101 through the pressure relief passage 105; the control device 107 is connected to the flow restriction 113; when the pressure relief passage 105 is opened, the control device 107 controls to activate the flow limiting member 113; when the pressure relief passage 105 is closed, the control device 107 controls to close the flow restriction 113.
Here, the flow restriction member 113 may be a flow restriction valve or a connection pipe having a small pipe diameter. The pressure relief passage 105 may be in communication with atmospheric pressure through a flow restriction 113, or may be in communication with a positive and negative pressure source, i.e., a negative pressure source when positive pressure is established in the gas storage device 101; when the reservoir 101 establishes negative pressure, it communicates with a positive pressure source, and the connection of the flow restriction 113 and the pressure relief passageway 105 may be combined in any manner.
In the embodiment of the present application, the flow limiting member 113 is used for adjusting the pressure relief flow rate of the gas storage device 101, and the control device 107 can control the flow limiting member to slowly and stably release the negative pressure or the positive pressure in the gas storage tank 1, so that the problem that the pressure of the gas storage device 101 needs to be built repeatedly due to pressure relief overshoot can be avoided, and the pressure relief stability of the liquid path system of the sample analyzer is enhanced.
In some embodiments, referring to fig. 4, an embodiment of the present application further provides a pressure build-up control method for a fluid path system including the sample analyzer in any one of the above embodiments, which is applied to a control apparatus, and includes:
s401: and controlling the pressure building passage to be opened according to the received trigger signal.
Here, the trigger signal is used for triggering the control device to start the voltage build-up control method, and may include at least one of the following: starting signals of the counting pool or starting signals of the manual starting control equipment or starting signals of the automatic starting control equipment when reaching a preset time point or stopping signals of the counting pool after the counting flow is executed. The controlling the pressure building path to be opened according to the received trigger signal may refer to: when the control equipment detects that the counting cell is started in a counting mode and confirms that the counting cell needs a gas storage device to provide stable negative pressure for the counting cell, the control equipment controls the first control valve to be opened so that the pressure source can establish negative pressure for the gas storage device; or, the control equipment detects an operation signal of a user to a self-starting button, confirms that negative pressure needs to be established on the gas storage device, and controls the first control valve to open so that the pressure source establishes negative pressure for the gas storage device; or, the control equipment detects that the time interval between the last pressure buildup of the gas storage device and the last pressure buildup reaches preset time, and controls the opening of the first control valve to enable the pressure source to establish negative pressure for the gas storage device if the situation that negative pressure needs to be established again for the gas storage device is confirmed; or, the control device detects that the counting cell executes the counting process, and controls the third control valve to open to enable the pressure source to establish positive pressure for the gas storage device when determining that the waste liquid in the gas storage device needs to be removed.
S402: receiving the current pressure value detected by the pressure detection element, and controlling the current pressure value of the gas storage device to be adjusted to a second preset pressure value within a first preset time range when the current pressure value in the gas storage device is obtained to reach a first preset pressure value; and the absolute value of the first preset pressure value is greater than the absolute value of the second preset pressure value.
Here, the receiving the current pressure value detected by the pressure detection element, and when the current pressure value in the gas storage device is obtained to reach a first preset pressure value, controlling the pressure building passage to be closed and controlling the current pressure value of the gas storage device to be adjusted to a second preset pressure value within a first preset time range may refer to: the control equipment collects the current pressure value detected by the pressure detection element in real time, compares the current pressure value with the first preset pressure value, confirms that the pressure building controlled by the gas storage device needs to be suspended when the current pressure value in the gas storage device is obtained to reach the first preset pressure value, namely controls the first control valve to be closed, and simultaneously controls the current pressure value of the gas storage device to be adjusted to the second preset pressure value within the first preset time range.
In the embodiment of the application, the pressure building control method for the liquid path system of the sample analyzer, the control device can enable the air pressure in the air storage device to be rebalanced within a certain time after the air pressure is built rapidly, so that the air pressure in the air storage device can reach the target pressure value more stably and accurately, and the condition that the pressure building is inaccurate due to the fact that the pressure rebalancing occurs after the air pressure in the air storage device is closed due to the pressure source is effectively avoided.
In some embodiments, the controlling the pressure buildup path to be closed when the current pressure value in the gas storage device is obtained and reaches a first preset pressure value, and controlling the current pressure value of the gas storage device to be adjusted to a second preset pressure value within a first preset time range includes: when the current pressure value in the air storage device reaches a first preset pressure value, the negative pressure passage is controlled to be closed, a timer is controlled to start timing, and the pressure relief passage is controlled to be opened when the reading of the timer reaches a first preset time length; and when the current pressure value in the gas storage device is acquired to reach a second preset pressure value, the control equipment controls the pressure relief passage to be closed.
Fig. 5 is a graph showing the pressure change in the gas storage device when the control device controls the pressure source to create negative pressure in the gas storage device in the prior art. As can be seen from fig. 5, the control device controls the pressure source to start to build negative pressure to the gas storage device at t1, and stops building negative pressure to the gas storage device at t 2. And during the period from t2 to t3, the negative pressure in the air storage device reaches the target pressure value after rebalancing. In the embodiment of the present application, please refer to fig. 6, which is a graph illustrating a pressure change curve in the gas storage device after the control device controls the pressure source to build negative pressure for the gas storage device in the embodiment of the present application. Here, when the current pressure value obtained in the gas storage device reaches a first preset pressure value, the negative pressure passage is controlled to be closed, a timer is controlled to start timing, and when it is determined that the reading of the timer reaches a first preset time length, the pressure relief passage is controlled to be opened, which may be: the control equipment controls the pressure source to be started at t4 to establish negative pressure on the gas storage device, and controls the first control valve to be closed when the control equipment acquires that the current negative pressure value in the gas storage device reaches a first preset pressure value (namely at t 5) through the pressure detection element; meanwhile, the control device controls to start a timer to start timing (namely at t 5), collects the time length value of the timer in real time, and controls the second control valve to be opened when the collected reading of the timer reaches a first preset time length (namely at t 6). When the control device detects that the negative pressure value in the gas storage device reaches a second preset pressure value (namely t 7) through the pressure detection element, the second control valve is controlled to be closed, and the current negative pressure value in the gas storage device is determined to be a target pressure value.
In the embodiment of the application, when the control device detects that the current negative pressure value in the gas storage device reaches a first preset pressure value, the first control valve is controlled to be closed, and the second control valve is controlled to be opened after waiting for the first preset time pause time, so that the negative pressure in the gas storage device can be guaranteed to have enough time to be rebalanced, the problem that the pressure in the gas storage device is inaccurate due to the fact that the pressure source pressurizes too fast in the prior art is effectively solved, and the air pressure in the gas storage device can reach a target pressure value more stably and accurately. Therefore, when the counting flow is executed by the counting cell, the gas storage device can provide negative pressure with higher accuracy and better stability for the counting cell.
In some embodiments, the controlling the pressure buildup path to be closed when the current pressure value in the gas storage device is obtained and reaches a first preset pressure value, and controlling the current pressure value of the gas storage device to be adjusted to a second preset pressure value within a first preset time range includes: when the current pressure value in the gas storage device reaches a third preset pressure value, controlling the positive pressure passage to be closed, controlling a timer to start timing, and controlling the pressure relief passage to be opened when the reading of the timer reaches a second preset time length; and when the current pressure value in the gas storage device reaches a second preset pressure value, the control equipment controls the pressure relief passage to be closed.
Referring now to FIG. 7, a graph illustrating the pressure change in the gas storage device when the control device controls the pressure source to create positive pressure in the gas storage device according to the present embodiment is shown. When the current pressure value in the acquired gas storage device reaches a third preset pressure value, the positive pressure passage is controlled to be closed, the timer is controlled to start timing, and the pressure relief passage is controlled to be opened when the reading of the timer reaches a second preset time length: the control equipment controls the pressure source to be started at t8 to establish positive pressure on the gas storage device, and when the current positive pressure value acquired by the control equipment through the pressure detection element in the gas storage device reaches a third preset pressure value (namely at t 9), the third control valve is controlled to be closed; meanwhile, the control device controls to start a timer to start timing (namely at t 9), collects the time length value of the timer in real time, and controls the second control valve to be opened when the collected reading of the timer reaches a first preset time length (namely at t 10). When the control device detects that the positive pressure value in the gas storage device reaches a fourth preset pressure value (namely t 11) through the pressure detection element, the second control valve is controlled to be closed, and the current positive pressure value in the gas storage device is determined to be a target pressure value.
In the embodiment of the application, when the controlgear detects current malleation value in the gas storage device reaches the third and predetermines the pressure value, control the third control valve is closed to wait for the second to predetermine after the dwell time of duration again control the second control valve is opened, can guarantee malleation in the gas storage device has sufficient time to carry out rebalance, has effectively solved among the prior art because the pressure source pressurization leads to too fast the inaccurate problem of pressure in the gas storage device, thereby can be more stable, more accurate messenger atmospheric pressure in the gas storage device reaches the target pressure value.
For convenience of understanding, the present embodiment of the application describes a method for using a fluid path system of the sample analyzer more generally, please refer to fig. 8, where the method is applied to a control apparatus, and includes:
s801, when detecting that the interval time between the gas storage device and the last pressure building reaches preset time, the control equipment controls the opening of a first control valve to enable a pressure source to build negative pressure for the gas storage device;
s802, when the control equipment detects that the current negative pressure value of the gas storage device reaches a first preset pressure value through the pressure detection element, the control equipment controls the first control valve to be closed, and meanwhile, the control equipment controls the timer to be started for timing;
s803, when the control equipment detects that the counting time of the timer reaches a first preset time, controlling the second control valve to be opened;
s804, when the control equipment detects that the current negative pressure value of the gas storage device reaches a second preset pressure value, the control equipment controls a second control valve to close;
s805, the control equipment controls the opening of the fourth control valve to enable the gas storage device to provide stable negative pressure for the counting cell, and the counting cell executes a counting process;
s806, the control equipment detects that the counting cell completes the counting process, and controls to open the fifth control valve so as to extract the residual sample liquid to be detected in the counting cell to a gas storage device;
s807, controlling equipment to control a sixth control valve to open so as to inject diluent into the counting cell for cleaning; here, the diluent for washing the forebay is extracted to the gas storage device through the second liquid extraction path; the diluent for cleaning the rear pool is extracted to the gas storage device through the first liquid extraction passage;
s808, controlling the fourth control valve, the fifth control valve and the sixth control valve to be closed and controlling the third control valve to be opened to establish positive pressure on the gas storage device by the control equipment;
s809, when the control equipment detects that the current positive pressure value of the gas storage device reaches a third preset pressure value through the pressure detection element, the control equipment controls a third control valve to close, and meanwhile, the control equipment controls a timer to start timing;
s810, controlling a second control valve to be opened when the control equipment detects that the counting time of the timer reaches a second preset time;
s811, when the control equipment detects that the current positive pressure value of the gas storage device reaches a fourth preset pressure value, the control equipment controls the second control valve to close;
and S812, controlling the waste liquid in the gas storage device to be discharged by the control equipment.
In the embodiment of the application, the pressure building control method for the liquid path system of the sample analyzer can ensure that the negative pressure or positive pressure in the gas storage device has enough time to rebalance, thereby effectively solving the problem of inaccurate pressure in the gas storage device caused by too fast pressurization of a pressure source in the prior art, and further more stably and accurately enabling the air pressure in the gas storage device to reach the target pressure value.
In some embodiments, the present application further provides a sample analyzer including the fluid path system of the sample analyzer of any of the above embodiments.
The above description is only for the specific embodiments of the present application, but the scope of the present application is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present application, and shall be covered by the scope of the present application. Therefore, the protection scope of the present application shall be subject to the protection scope of the claims.
Claims (11)
1. A liquid path system of a sample analyzer is characterized by comprising a gas storage device, a pressure source and a counting cell which are connected with the gas storage device, a pressure building passage connected between the gas storage device and the pressure source, a pressure detection element connected with the gas storage device and a control device;
the control equipment is connected with the pressure building passage and the pressure detection element; the pressure detection element is used for detecting the current pressure value in the gas storage device;
when the counting cell is in a preset state, the control equipment controls the pressure building passage to be opened, and the pressure source builds pressure on the gas storage device;
when the current pressure value in the gas storage device reaches a first preset pressure value, the control equipment controls the pressure building passage to be closed, and controls the current pressure value of the gas storage device to be adjusted to a second preset pressure value within a first preset time range; and the absolute value of the first preset pressure value is greater than the absolute value of the second preset pressure value.
2. The fluid path system of a sample analyzer of claim 1, wherein the pressure build-up path comprises a negative pressure path, the fluid path system further comprising a pressure relief path and a timer,
the control equipment is connected with the negative pressure passage, the pressure relief passage, the timer and the pressure detection element;
when the counting cell is started for counting, the control equipment controls the negative pressure passage to be opened and the pressure relief passage to be closed, and the pressure source establishes negative pressure on the gas storage device;
when the current pressure value in the gas storage device reaches a first preset pressure value, the control equipment controls the negative pressure passage to be closed, controls the timer to start timing, and controls the pressure relief passage to be opened when the reading of the timer reaches a first preset time length;
the gas storage device is decompressed through the decompression passage, when the current pressure value in the gas storage device reaches a second preset pressure value, the control device controls the decompression passage to be closed, and the counting cell executes a counting process.
3. The fluid path system of a sample analyzer of claim 1, wherein the pressure build-up path comprises a positive pressure path, the fluid path system further comprising a pressure relief path and a timer,
the control equipment is connected with the positive pressure passage, the pressure relief passage, the timer and the pressure detection element;
when the counting pool stops counting, the control equipment controls the positive pressure passage to be opened and the pressure relief passage to be closed, and the pressure source establishes positive pressure on the gas storage device;
when the current pressure value in the gas storage device reaches a first preset pressure value, the control equipment controls the positive pressure passage to be closed and controls the timer to start timing, and when the reading of the timer reaches a second preset time length, the pressure relief passage is controlled to be opened;
the gas storage device carries out pressure relief through the pressure relief passage, when the current pressure value in the gas storage device reaches a second preset pressure value, the control equipment controls the pressure relief passage to be closed, and the gas storage device executes a waste liquid discharge flow.
4. The fluid path system of sample analyzer as claimed in claim 2, further comprising a first fluid pumping path connected between the counting cell and the gas storage device,
in the process that the counting cell executes a counting process, the control equipment controls the first liquid pumping passage to be opened, the gas storage device pumps the sample liquid to be detected in the counting cell into the gas storage device through the current pressure in the gas storage device and the first liquid pumping passage, and the control equipment determines the counting value of the cells in the sample liquid to be detected according to level signals generated when the cells in the sample liquid to be detected are filtered.
5. The fluid path system of sample analyzer as claimed in claim 2, further comprising a second fluid-pumping path connecting the counting cell and the gas storage device,
when the counting cell completes the counting process, the control device controls the second liquid pumping passage to be opened, and the gas storage device pumps the residual sample liquid to be detected in the counting cell into the gas storage device through the second liquid pumping passage.
6. The fluid path system of a sample analyzer as claimed in claim 1, further comprising a plurality of fluid paths connecting the count cell and the diluent,
when the counting flow is completed in the counting pool, the control equipment controls the plurality of liquid adding passages to be opened simultaneously, and the diluent is filled into the counting pool through the plurality of liquid adding passages.
7. The fluid path system of the sample analyzer of any one of claims 2 to 5, further comprising a flow restriction member, wherein the flow restriction member is connected to the gas storage device through the pressure relief passage; the flow limiting piece is used for adjusting the pressure relief flow of the gas storage device.
8. A pressure buildup control method of a fluid path system of a sample analyzer according to any one of claims 1 to 7, applied to a control apparatus, comprising:
controlling the pressure building passage to be opened according to the received trigger signal;
receiving the current pressure value in the gas storage device detected by the pressure detection element, and controlling the pressure building passage to be closed when the current pressure value in the gas storage device reaches a first preset pressure value; and controlling the current pressure value of the gas storage device to be adjusted to a second preset pressure value within a first preset time range, wherein the absolute value of the first preset pressure value is greater than the absolute value of the second preset pressure value.
9. The pressure build-up control method according to claim 8, wherein the pressure build-up passage comprises a negative pressure passage, the fluid path system further comprises a pressure relief passage and a timer,
the control equipment is connected with the negative pressure passage, the pressure relief passage, the timer and the pressure detection element;
when the counting cell is started for counting, the control equipment controls the negative pressure passage to be opened and the pressure relief passage to be closed so that the pressure source can establish negative pressure on the gas storage device;
when the current pressure value obtained in the gas storage device reaches a first preset pressure value, controlling the pressure building passage to be closed, and controlling the current pressure value of the gas storage device to be adjusted to a second preset pressure value within a first preset time range comprises:
when the current pressure value in the air storage device reaches a first preset pressure value, the negative pressure passage is controlled to be closed, a timer is controlled to start timing, and the pressure relief passage is controlled to be opened when the reading of the timer reaches a first preset time length;
and when the current pressure value in the gas storage device is acquired to reach a second preset pressure value, the control equipment controls the pressure relief passage to be closed.
10. The pressure build-up control method according to claim 8, wherein the pressure build-up path comprises a positive pressure path, the fluid path system further comprises a pressure relief path and a timer,
the control equipment is connected with the positive pressure passage, the pressure relief passage, the timer and the pressure detection element;
when the counting pool stops counting, the control equipment controls the positive pressure passage to be opened and the pressure relief passage to be closed so that the pressure source can establish positive pressure on the gas storage device;
when the current pressure value obtained in the gas storage device reaches a first preset pressure value, controlling the pressure building passage to be closed, and controlling the current pressure value of the gas storage device to be adjusted to a second preset pressure value within a first preset time range comprises:
when the current pressure value in the gas storage device is obtained and reaches a first preset pressure value, the positive pressure passage is controlled to be closed, a timer is controlled to start timing, and the pressure relief passage is controlled to be opened when the reading of the timer reaches a second preset time length; and when the current pressure value in the gas storage device reaches a second preset pressure value, the control equipment controls the pressure relief passage to be closed.
11. A sample analyzer comprising the fluid path system of the sample analyzer of any of claims 1-7.
Priority Applications (2)
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| CN202210434794.7A CN114527055B (en) | 2022-04-24 | 2022-04-24 | Sample analyzer, liquid path system thereof and pressure building control method |
| PCT/CN2022/144435 WO2023207208A1 (en) | 2022-04-24 | 2022-12-31 | Sample analyzer and pressure buildup control method therefor |
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| CN202210434794.7A CN114527055B (en) | 2022-04-24 | 2022-04-24 | Sample analyzer, liquid path system thereof and pressure building control method |
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| WO2023207208A1 (en) * | 2022-04-24 | 2023-11-02 | 深圳市帝迈生物技术有限公司 | Sample analyzer and pressure buildup control method therefor |
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| CN205246681U (en) * | 2015-12-21 | 2016-05-18 | 深圳联开生物医疗科技有限公司 | Piston negative pressure dynamic adjustment system and hematology analyzer |
| CN105806767A (en) * | 2016-03-11 | 2016-07-27 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | Fluid circuit system of flow cytometer and flow cytometer |
| CN110031644A (en) * | 2017-06-30 | 2019-07-19 | 深圳迈瑞生物医疗电子股份有限公司 | Agent delivery device, sample analyser and agent delivery method |
| CN114527055B (en) * | 2022-04-24 | 2022-07-15 | 深圳市帝迈生物技术有限公司 | Sample analyzer, liquid path system thereof and pressure building control method |
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| WO2019000460A1 (en) * | 2017-06-30 | 2019-01-03 | 深圳迈瑞生物医疗电子股份有限公司 | Sample analyzer and driving method therefor |
| CN109212246A (en) * | 2017-06-30 | 2019-01-15 | 深圳迈瑞生物医疗电子股份有限公司 | Liquid feed device, sample analyser build pressure device and feed liquid method |
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