Classifications

• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
  • C08G18/00—Polymeric products of isocyanates or isothiocyanates
  • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
  • C08G18/08—Processes
  • C08G18/10—Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
  • C08G18/00—Polymeric products of isocyanates or isothiocyanates
  • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
  • C08G18/08—Processes
  • C08G18/10—Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
  • C08G18/12—Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step using two or more compounds having active hydrogen in the first polymerisation step
• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
  • C08G18/00—Polymeric products of isocyanates or isothiocyanates
  • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
  • C08G18/08—Processes
  • C08G18/16—Catalysts
  • C08G18/22—Catalysts containing metal compounds
  • C08G18/222—Catalysts containing metal compounds metal compounds not provided for in groups C08G18/225 - C08G18/26
• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
  • C08G18/00—Polymeric products of isocyanates or isothiocyanates
  • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
  • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
  • C08G18/30—Low-molecular-weight compounds
  • C08G18/32—Polyhydroxy compounds; Polyamines; Hydroxyamines
  • C08G18/3203—Polyhydroxy compounds
  • C08G18/3206—Polyhydroxy compounds aliphatic
• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
  • C08G18/00—Polymeric products of isocyanates or isothiocyanates
  • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
  • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
  • C08G18/40—High-molecular-weight compounds
  • C08G18/42—Polycondensates having carboxylic or carbonic ester groups in the main chain
  • C08G18/4236—Polycondensates having carboxylic or carbonic ester groups in the main chain containing only aliphatic groups
  • C08G18/4238—Polycondensates having carboxylic or carbonic ester groups in the main chain containing only aliphatic groups derived from dicarboxylic acids and dialcohols
• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
  • C08G18/00—Polymeric products of isocyanates or isothiocyanates
  • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
  • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
  • C08G18/40—High-molecular-weight compounds
  • C08G18/42—Polycondensates having carboxylic or carbonic ester groups in the main chain
  • C08G18/4266—Polycondensates having carboxylic or carbonic ester groups in the main chain prepared from hydroxycarboxylic acids and/or lactones
  • C08G18/4269—Lactones
  • C08G18/4277—Caprolactone and/or substituted caprolactone
• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
  • C08G18/00—Polymeric products of isocyanates or isothiocyanates
  • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
  • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
  • C08G18/40—High-molecular-weight compounds
  • C08G18/48—Polyethers
  • C08G18/4804—Two or more polyethers of different physical or chemical nature
  • C08G18/4808—Mixtures of two or more polyetherdiols
• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
  • C08G18/00—Polymeric products of isocyanates or isothiocyanates
  • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
  • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
  • C08G18/40—High-molecular-weight compounds
  • C08G18/48—Polyethers
  • C08G18/4825—Polyethers containing two hydroxy groups
• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
  • C08G18/00—Polymeric products of isocyanates or isothiocyanates
  • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
  • C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
  • C08G18/72—Polyisocyanates or polyisothiocyanates
  • C08G18/73—Polyisocyanates or polyisothiocyanates acyclic
• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
  • C08G18/00—Polymeric products of isocyanates or isothiocyanates
  • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
  • C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
  • C08G18/72—Polyisocyanates or polyisothiocyanates
  • C08G18/74—Polyisocyanates or polyisothiocyanates cyclic
  • C08G18/75—Polyisocyanates or polyisothiocyanates cyclic cycloaliphatic
  • C08G18/751—Polyisocyanates or polyisothiocyanates cyclic cycloaliphatic containing only one cycloaliphatic ring
  • C08G18/752—Polyisocyanates or polyisothiocyanates cyclic cycloaliphatic containing only one cycloaliphatic ring containing at least one isocyanate or isothiocyanate group linked to the cycloaliphatic ring by means of an aliphatic group
  • C08G18/753—Polyisocyanates or polyisothiocyanates cyclic cycloaliphatic containing only one cycloaliphatic ring containing at least one isocyanate or isothiocyanate group linked to the cycloaliphatic ring by means of an aliphatic group containing one isocyanate or isothiocyanate group linked to the cycloaliphatic ring by means of an aliphatic group having a primary carbon atom next to the isocyanate or isothiocyanate group
  • C08G18/755—Polyisocyanates or polyisothiocyanates cyclic cycloaliphatic containing only one cycloaliphatic ring containing at least one isocyanate or isothiocyanate group linked to the cycloaliphatic ring by means of an aliphatic group containing one isocyanate or isothiocyanate group linked to the cycloaliphatic ring by means of an aliphatic group having a primary carbon atom next to the isocyanate or isothiocyanate group and at least one isocyanate or isothiocyanate group linked to a secondary carbon atom of the cycloaliphatic ring, e.g. isophorone diisocyanate
• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
  • C08G18/00—Polymeric products of isocyanates or isothiocyanates
  • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
  • C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
  • C08G18/72—Polyisocyanates or polyisothiocyanates
  • C08G18/74—Polyisocyanates or polyisothiocyanates cyclic
  • C08G18/76—Polyisocyanates or polyisothiocyanates cyclic aromatic
  • C08G18/7657—Polyisocyanates or polyisothiocyanates cyclic aromatic containing two or more aromatic rings
  • C08G18/7664—Polyisocyanates or polyisothiocyanates cyclic aromatic containing two or more aromatic rings containing alkylene polyphenyl groups
  • C08G18/7671—Polyisocyanates or polyisothiocyanates cyclic aromatic containing two or more aromatic rings containing alkylene polyphenyl groups containing only one alkylene bisphenyl group
• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
  • C08G18/00—Polymeric products of isocyanates or isothiocyanates
  • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
  • C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
  • C08G18/72—Polyisocyanates or polyisothiocyanates
  • C08G18/77—Polyisocyanates or polyisothiocyanates having heteroatoms in addition to the isocyanate or isothiocyanate nitrogen and oxygen or sulfur
  • C08G18/78—Nitrogen
  • C08G18/7806—Nitrogen containing -N-C=0 groups
  • C08G18/7818—Nitrogen containing -N-C=0 groups containing ureum or ureum derivative groups
  • C08G18/7837—Nitrogen containing -N-C=0 groups containing ureum or ureum derivative groups containing allophanate groups
• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
  • C08L75/00—Compositions of polyureas or polyurethanes; Compositions of derivatives of such polymers
  • C08L75/04—Polyurethanes
  • C08L75/06—Polyurethanes from polyesters
• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
  • C08L75/00—Compositions of polyureas or polyurethanes; Compositions of derivatives of such polymers
  • C08L75/04—Polyurethanes
  • C08L75/08—Polyurethanes from polyethers
• • C—CHEMISTRY; METALLURGY
  • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
  • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
  • C09D175/00—Coating compositions based on polyureas or polyurethanes; Coating compositions based on derivatives of such polymers
  • C09D175/04—Polyurethanes
  • C09D175/06—Polyurethanes from polyesters
• • C—CHEMISTRY; METALLURGY
  • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
  • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
  • C09D175/00—Coating compositions based on polyureas or polyurethanes; Coating compositions based on derivatives of such polymers
  • C09D175/04—Polyurethanes
  • C09D175/08—Polyurethanes from polyethers
• • C—CHEMISTRY; METALLURGY
  • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
  • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
  • C09J175/00—Adhesives based on polyureas or polyurethanes; Adhesives based on derivatives of such polymers
  • C09J175/04—Polyurethanes
  • C09J175/06—Polyurethanes from polyesters
• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
  • C08G2150/00—Compositions for coatings
• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
  • C08G2170/00—Compositions for adhesives

Definitions

• the present invention relates to a isocyanate-terminated prepolymer for example for coating applications, to a process for preparing the isocyanate -terminated prepolymer and to the use of the isocyanate-terminated prepolymer.
• the present invention further relates to a two- component-system, comprising a component A) comprising at least the isocyanate - terminated prepolymer and a component B) comprising at least one compound which comprises at least one Zerewitinoff-active group.
• isocyanate-terminated prepolymers can be used as curing components in polyurethane coating or coating systems. These prepolymers are generally obtained by reacting polyols with di- or polyisocyanates. As a curing component, the prepolymers then react in the coating or coating system with further polyols, for example with polyacrylate polyols, to give the corresponding polyurethanes.
• the coating system can for example be used in original equipment manufacturer (OEM) coating processes or manual coating application in the refinish sector.
• OEM original equipment manufacturer
• the skin sensitisation potential date of commercial products are available from a safety data sheet (SDS) attached to each product.
• SDSs complied with Globally Harmonized System of Classification and Labelling of Chemicals (GHS) are preferred.
• GHS Globally Harmonized System of Classification and Labelling of Chemicals
• Some isocyanate- terminated prepolymers may cause an allergic reaction with the skin upon contact with them and accordingly the SDS of the isocyanate-terminated prepolymers has H317 as GHS hazard statement .
• the object of the present invention is to provide isocyanate-terminated prepolymers with reduced skin sensitisation potential or even which have no skin sensitisation potential.
• an isocyanate-terminated prepolymer which has no skin sensitisation potential refers to a compound that is evaluated as having a lysine mean depletion in the modified Direct Peptide Reactivity Assay (DPRA) test of ⁇ 1.00 %.
• the Direct Peptide Reactivity Assay (DPRA) is designed to mimic the covalent binding of electrophilic chemicals to nucleophilic centers in skin proteins by quantifying the reactivity of chemicals towards the model synthetic peptides containing either cysteine or lysine.
• the object has surprisingly been achieved by providing an isocyanate-term inated prepolymer obtained or obtainable by reaction of
• At least one monomeric diisocyanate wherein the isocyanate-terminated prepolymer has i. a functional group equivalent weight FGEW of > 560 g/mol, ii. a content of residual non-reacted monomeric diisocyanate of less than 0.2 % by weight, based on the total solid content of the isocyanate-terminated prepolymer.
• FGEW functional group equivalent weight
• An advantage of the isocyanate-terminated prepolymers according to the invention is that the working safety of workers using the isocyanate-terminated prepolymers according to the invention is increased.
• the safety labelling and associated risk phrases can be less stringent compared to isocyanate-terminated prepolymers not according to the invention, which advantageously results in less stringent safety measures and protection prescriptions for using isocyanate-terminated prepolymers according to the invention.
• these prepolymers can advantageously be used in manual applications, such as manual coating applications or in foaming or sealants in the building industry.
• NCO-terminated or isocyanate- terminated refers to a prepolymer that contain at least one free NCO-group at one of their ends.
• functional group equivalent weight FGEW“ refers to the number average molecular weight per isocyanate functional group, and is a value obtained by dividing the number average molecular weight (M n ) of the isocyanate terminated prepolymer, obtained via Gel permeation Chromatography, by the average number of isocyanate groups per molecule (NCO functionality).
• the isocyanate-terminated prepolymer has a functional group equivalent weight FGEW of > 560 g/mol, preferably > 600 g/mol, more preferably > 650 g/mol, more preferably > 700 g/mol, even more preferably > 800 g/mol and even more preferably > 1000 g/mol.
• FGEW functional group equivalent weight
• the isocyanate- terminated prepolymer preferably has a functional group equivalent weight FGEW of ⁇ 10000 g/mol, preferably ⁇ 4000 g/mol, more preferably ⁇ 2000 g/mol.
• the isocyanate-terminated prepolymer according to the invention has a content of residual non-reacted monomeric diisocyanate of ⁇ 0.2 % by weight, preferably ⁇ 0.1 % by weight, based on the total solid content of the isocyanate-terminated prepolymer. This has the advantage that the working safety of workers using the isocyanate-terminated prepolymers according to the invention is further increased.
• the isocyanate-terminated prepolymer according to the invention preferably has a numberaverage molecular weight M n of from 1100 to 160000 g/mol, preferably from 1100 to 64000 g/mol, more preferably from 1100 to 32000 g/mol.
• the average molecular weight is defined as the number average molecular weight M n .
• M n is determined via gel permeation chromatography (GPC) at 23°C in tetra hydrofuran as the solvent.
• the isocyanate-terminated prepolymer according to the invention preferably has a content of ⁇ 15 % by weight of oligomers having a number average molecular weight ⁇ 1000 g/mol, based on the total solid content of the NCO-terminated prepolymer.
• At least one monomeric diisocyanate wherein the at least one monomeric diisocyanate and the at least one polyol are used in an amount such that the NCO/OH equivalent ratio is from 1.5:1 to 25: 1 , preferably from 2: 1 to 20:1.
• the at least one polyol comprises one or more hydroxyl groups per molecule and can be any suitable polyol to obtain an isocyanate-terminated prepolymer according to the invention.
• the at least one polyol may comprise an individual polyol or a mixture of two or more polyols.
• the at least one polyol preferably has an average number-average molecular weight M n of from 60 to 20000 g/mol, preferably from 60 to 8000 g/mol, more preferably from 60 to 4000 g/mol.
• the individual polyol preferably has a numberaverage molecular weight M n of from 60 to 20000 g/mol, preferably from 60 to 8000 g/mol, more preferably from 60 to 4000 g/mol.
• the at least one polyol preferably has an average OH functionality from 2 to 8, preferably from 2 to 6, more preferably from 2 to 4.
• the individual polyol preferably has an OH functionality from 2 to 8, preferably from 2 to 6, more preferably from 2 to 4.
• the mixture of polyols preferably has an average OH functionality from 2 to 8, preferably from 2 to 6, more preferably from 2 to 4.
• the concept of the OH functionality is familiar to the skilled person. It indicates the number of OH groups (hydroxyl groups) that are present on average per molecule. Pure diols have an OH functionality of 2.0.
• the OH functionality of a polyol is given by the supplier of the polyol and can be determined by the functionality of the components used to prepare the polyol.
• the at least one polyol is preferably selected from the group consisting of polyester polyols, polyether polyols, polyether polyester polyols, polycarbonate polyols, polyether polycarbonate polyols, polyether polyester polycarbonate polyols and mixtures thereof. In principle, these polyols are known to the person skilled in the art.
• the acids or acid derivatives used for the preparation of the polyester polyols may be aliphatic, cycloaliphatic and/or aromatic and may be optionally substituted and/or unsaturated, for example by halogen atoms.
• suitable acids are polybasic carboxylic acids having a molecular weight of 118 to 300 g/mol or derivatives thereof, such as succinic acid, adipic acid, sebacic acid, phthalic acid, isophthalic acid, trimellitic acid, phthalic anhydride, tetrahydrophthalic acid, maleic acid, maleic anhydride, dimeric and trimeric fatty acids, dimethyl terephthalate and bis-glycol terephthalic acid esters.
• Preferred polyester polyols are polycaprolactone polyols.
• Polyhydroxyl compounds of the polycarbonate type which are suitable are the polycarbonate polyols known per se, such as can be prepared, for example, by reacting dihydric alcohols, having a molecular weight range of 62 to 400 g/mol, with diaryl carbonates, such as, for example, diphenyl carbonate, dialkyl carbonates, such as, for example, dimethyl carbonate, or phosgene.
• Suitable polyether polyols are, in particular, as are obtainable in a manner known per se by alkoxylation of suitable starter molecules.
• any desired polyhydric alcohols such as the simple polyhydric alcohols having 2 to 14 carbon atoms, can be used as starter molecules.
• Aliphatic and/or aromatic amines are also suitable starter molecules.
• Alkyl oxides suitable for the alkoxylation reaction are, in particular, ethylene oxide and propylene oxide, which can be used in any desired sequence or else in a mixture in the alkoxylation reaction.
• Suitable polyether polyols are also the polyoxytetramethylene glycols known per se, by polymerization of tetrahydrofuran.
• Suitable polyether polyester polyols are for example those obtained by the addition of epoxies to the esterification product of an aromatic dicarboxylic acid derivative and a difunctional or higher-functional alcohol.
• the at least one polyol is preferably selected from the group consisting of polyester polyols, polyether polyols, and mixtures thereof.
• the at least one monomeric diisocyanate can be any suitable diisocyanate, meaning that any compound which includes two isocyanate groups is within the contemplation of the present invention. Aliphatic, cycloaliphatic or aromatic diisocyanates may in principle be used.
• aromatic diisocyanates examples include toluene-2,4-diisocyanate, toluene-2,6-diisocyanate, 4,4’-diphenylmethane diisocyanate, 2,4’- diphenylmethane diisocyanate, 2,2’-diphenylmethane diisocyanate, polymeric or oligomeric diphenylmethane diisocyanate, 1 ,5-napthalene diisocyanate and mixtures thereof.
• Aliphatic diisocyanates and cycloaliphatic diisocyanates are preferred.
• the at least one monomeric diisocyanate is preferably an aliphatic diisocyanate and/or a cycloaliphatic diisocyanate. Accordingly, the isocyanate-terminated prepolymer is preferably obtained or obtainable by reaction of
• At least one monomeric aliphatic diisocyanate and/or at least one monomeric cycloaliphatic diisocyanate At least one monomeric aliphatic diisocyanate and/or at least one monomeric cycloaliphatic diisocyanate.
• An aliphatic diisocyanate is a compound in which the two isocyanate groups are directly bonded to an aliphatic hydrocarbon group, irrespective of whether aromatic groups are present in the compound.
• the term “aliphatic hydrocarbon group” refers to optionally branched alkyl, alkenyl and alkynyl group.
• a cycloaliphatic diisocyanate is a compound in which one or more isocyanate groups are directly bonded to a cycloaliphatic hydrocarbon group, irrespective of whether aromatic groups are present in the compound.
• cycloaliphatic hydrocarbon group refers to cycloalkyl and cycloalkenyl group optionally substituted with at least one aliphatic hydrocarbon group.
• the aliphatic diisocyanate is selected from the group consisting of 1 ,5-diisocyanatopentane, 1 ,6- diisocyanatohexane, 2,2,4-trimethyl hexamethylene diisocyanate, 2,4,4-trimethyl hexamethylene diisocyanate and mixtures thereof.
• the cycloaliphatic diisocyanate is preferably selected from the group consisting of isophorone diisocyanate (IPDI), 1-isocyanato-4-[(4-isocyanatocyclohexyl)methyl]cyclohexane (H12MDI), 1 ,3-bis(isocyanatomethyl)cyclohexane and mixtures thereof
• the diisocyanate is selected from the group consisting of 1 ,5- diisocyanatopentane, 1 ,6-diisocyanatohexane, isophorone diisocyanate and mixtures thereof.
• the inventive NCO-terminated prepolymer can be diluted with a solvent inert toward isocyanate groups and preferably also toward the other reactive groups of the starting components.
• Suitable solvents are, for example, ethyl acetate, butyl acetate, ethylene glycol monomethyl or monoethyl ether acetate, 1-methoxyprop-2-yl acetate, 3-methoxy-n-butyl acetate, acetone, 2-butanone, 4-methyl-2-pentanone, cyclohexanone, toluene, xylene, chlorobenzene, white spirit, more highly substituted aromatics, of the kind available commercially, for example, under the names Solventnaphtha, Solvesso®, Isopar®, Nappar®, Varsol® (ExxonMobil Chemical Central Europe, Cologne, Germany) and Shellsol® (Shell GmbH, Hamburg, Germany), and also solvents such as propylene
• the invention further relates to a process for preparing the inventive NCO-terminated prepolymer comprising the following steps a) mixing at least one polyol with an excess of at least one monomeric diisocyanate at a temperature suitable to form urethane groups, b) optionally partly or fully allophanatizing the urethane groups by further reaction with at least one monomeric diisocyanate (which may be different from those from (a)) optionally in the presence of a catalyst, c) removal of the excess of the monomeric diisocyanate, if present, by distillation down to ⁇ 0.2 % by weight, preferably down to ⁇ 0.1 % by weight, based on the total solid content of the NCO-terminated prepolymer, to obtain the isocyanate-terminated prepolymer, and d) optionally addition of at least one solvent inert towards isocyanate groups.
• the process of the invention comprises the following steps a) mixing at least one polyol with an excess of at least one monomeric diisocyanate, b) partly or fully allophanatizing the urethane groups by further reaction with at least one monomeric diisocyanate (which may be different from those from (a)), c) removal of the excess of the monomeric diisocyanate, if present, by distillation down to ⁇ 0.2 % by weight, preferably down to ⁇ 0.1 % by weight, based on the NCO- terminated prepolymer, to obtain the isocyanate-terminated prepolymer, and d) optionally addition of at least one solvent inert towards isocyanate groups.
• step b) is preferably effected in the presence of a catalyst.
• the progress of the reaction in the process of the invention can be monitored by determining the NCO content by titrimetric means, for example as per DIN EN ISO 11909:2007-05.
• any urethanization catalysts used are preferably deactivated by addition of suitable catalyst poisons.
• Such catalyst poisons are, for example, inorganic acids such as hydrochloric acid, phosphorous acid or phosphoric acid, acid chlorides such as acetyl chloride, benzoyl chloride or isophthaloyl chloride, sulfonic acids and sulfonic esters, such as methanesulfonic acid, p- toluenesulfonic acid, trifluoromethanesulfonic acid, perfluorobutanesulfonic acid, dodecylbenzenesulfonic acid, methyl and ethyl p-toluenesulfonate, mono- and dialkyl phosphates such as monotridecyl phosphate, dibutyl phosphate and dioctyl phosphate, but also silylated acids such as trimethylsilyl methanesulfonate, trimethylsilyl trifluoromethanesulfonate, tris(trimethylsilyl) phosphate and die
• the amount of catalyst poison required for deactivation of the catalyst is guided by the amount of the catalyst used. In general, an equivalent amount of the catalyst poison is used, based on the urethanization catalyst used at the start. If, however, any catalyst losses that occur during the reaction are taken into account, even 20 to 80 equivalent% of the catalyst poison, based on the amount of catalyst originally used, may be sufficient to stop the reaction.
• Suitable solvents are, for example, the customary paint solvents that are known per se such as ethyl acetate, butyl acetate, ethylene glycol monomethyl or monoethyl ether acetate, 1- methoxyprop-2-yl acetate, 3-methoxy-n-butyl acetate, acetone, 2-butanone, 4-methyl-2- pentanone, cyclohexanone, toluene, xylene, chlorobenzene, white spirit, more highly substituted aromatics, of the kind available commercially, for example, under the names Solventnaphtha, Solvesso®, Isopar®, Nappar®, Varsol® (ExxonMobil Chemical Central Europe, Cologne, Germany) and Shellsol® (Shell GmbH, Hamburg, Germany), and also solvents such as propylene glycol
• the inventive NCO-terminated prepolymer is especially suitable for use in curable compositions for coating, adhesive, sealant and/or foam systems, which is a further aspect of the present invention. Since the inventive NCO-terminated prepolymers have reduced skin sensitisation potential or even have no skin sensitisation potential, the NCO-terminated prepolymers can very advantageously be applied for reducing and/or avoiding any concerns for skin sensitization effects on the persons which may become exposed to said isocyanate- terminated prepolymers. Therefore, the inventive NCO-terminated prepolymers can very advantageously be applied in particular in curable compositions for coating, adhesive, sealant and/or foam systems that are applied manually. All embodiments described or preferred for one subject of the present invention, e.g.
• a preferred coating system is a refinish coating system, in particular an automotive refinish coating system.
• the sealant and/or foam systems can very suitable be applied in the building industry, for example for insulation purpose and/or for filling cavities.
• the invention further pertains to a moisture-curable one-component system comprising at least one isocyanate-terminated prepolymer according to the invention, in particular to a moisture-curable one-component coating, adhesive, sealant or foam system comprising at least one isocyanate-terminated prepolymer according to the invention, more in particular the one-component system is a one-component foam system, in particular a one-component foam system for application in the building industry, in particular for manual application in the building industry.
• the invention further pertains to a two-component system, comprising a component A), comprising at least one isocyanate-terminated prepolymer according to the invention, and a component B), comprising at least one compound which comprises at least one Zerewitinoff- active group.
• the two-component system is in particular a two-component coating system, a two-component adhesive system, a two-component sealant system or a two-component foam system, in particular for manual application.
• the two-component system is a sealant system or an adhesive system, in particular for manual application in the building industry.
• the two-component system is a refinish coating system, in particular an automotive refinish system.
• Suitable compounds which comprises at least one Zerewitinoff-active group are, for example, the conventional polymeric polyether polyols, polyester polyols, polycarbonate polyols and/or polyacrylate polyols known from polyurethane chemistry, which usually have a numberaverage molecular weight of from 200 to 22,000, preferably from 250 to 18,000, particularly preferably from 250 to 12,000.
• polyurethane chemistry which usually have a numberaverage molecular weight of from 200 to 22,000, preferably from 250 to 18,000, particularly preferably from 250 to 12,000.
• a broad overview of suitable polymeric polyols can be found, for example, in N. Adam et al.: “Polyurethanes", Ullmann's Encyclopedia of Industrial Chemistry, Electronic Release, 7th ed., chap. 3.2 - 3.4, Wiley-VCH, Weinheim 2005.
• polyamines such as, for example, the polyaspartic acid derivatives known from EP-B 0 403 921 , or also those polyamines whose amino groups are present in blocked form, such as, for example, polyketimines, polyaldimines or oxazolanes, are also suitable as isocyanate-reactive binders. Free amino groups are formed from these blocked amino groups under the influence of moisture and, in the case of the oxazolanes, also free hydroxyl groups which react with crosslinking with the isocyanate groups of the diisocyanate.
• the at least one compound, which comprises at least one Zerewitinoff-active group is selected from polyester polyols, polyether polyols, polyurethane polyols, polyacrylate polyols, polymethacrylate polyols, polycarbonate polyols and mixtures thereof.
• auxiliaries and additives customary in the coating, adhesive, sealant or foam sector can be added to the system.
• suitable auxiliaries and additives are leveling auxiliaries, color pigments, filler materials, matting agents, inorganic or organic pigments, light stabilizers, lacquer additives, such as dispersants, leveling agents, thickeners, antifoams and other auxiliaries, adhesives, fungicides, bactericides, stabilizers or inhibitors and catalysts or emulsifiers.
• the invention further relates to a process for curing a moisture-curable one-component system on a substrate or in a cavity, comprising the following steps i) applying on at least one substrate or in a cavity at least one inventive moisture-curable one-component system and ii) exposing the deposited composition to a temperature of 0 to 120 °C, preferably of 20 to 90 °C and more preferred of 20 to 60 °C to cure said deposited composition.
• the invention further relates to a process for curing a two-component system on a substrate or in a cavity, comprising the following steps i. just prior to applying the two-component system on at least one substrate or in a cavity, mixing component A) and component B) of the two-component-system to obtain a mixture, ii. applying on at least one substrate or in the cavity said mixture, and iii. exposing the deposited composition to a temperature of 0 to 120 °C, preferably of 20 to 90 °C and more preferred of 20 to 60 °C to cure said deposited composition. Upon curing of the deposited composition, the cured composition forms a solid on the substrate or in the cavity.
• such solid is preferably a coating or an adhesive.
• such solid is preferably a sealant or a foam.
• the invention further pertains to a cured article obtainable or obtained by the inventive process for curing a moisture-curable one-component system or a two-component system composition on a substrate or in a cavity.
• the cured composition is a refinish coating and the substrate is a refinish substrate.
• the cured composition is preferably an automotive refinish coating and the substrate is a refinish automotive substrate.
• the cured composition is a foam or sealant in a building house.
• a further aspect of the present invention is the use of either the inventive NCO-terminated prepolymer or the inventive moisture-curable one-component system or the inventive two- component-system for coatings, especially in automotive repair applications or for foams and/or sealants, especially in the building industry.
• the invention relates to an isocyanate-terminated prepolymer obtained by reaction of
• the invention relates to the isocyanate-terminated prepolymer according to the first embodiment, wherein the isocyanate-terminated prepolymer has a functional group equivalent weight FGEW of > 600 g/mol, preferably > 650 g/mol, more preferably > 700 g/mol, even more preferably > 800 g/mol, even more preferably > 1000 g/mol.
• the invention relates to the isocyanate-terminated prepolymer according to the first or second embodiment, wherein the isocyanate- terminated prepolymer has a functional group equivalent weight FGEW of ⁇ 10000 g/mol, preferably ⁇ 4000 g/mol, more preferably ⁇ 2000 g/mol.
• the invention relates to the isocyanate-terminated prepolymer according to any one of the preceding embodiments, wherein the at least one polyol has an average number-average molecular weight Mn of from 60 to 20000 g/mol, preferably from 60 to 8000 g/mol, more preferably from 60 to 4000 g/mol.
• the invention relates to the isocyanate-terminated prepolymer according to any one of the preceding embodiments, wherein the at least one polyol is selected from the group consisting of polyester polyols, polyether polyols, polyether polyester polyols, polycarbonate polyols, polyether polycarbonate polyols, polyether polyester polycarbonate polyols and mixtures thereof.
• the invention relates to the isocyanate-terminated prepolymer according to any one of the preceding embodiments, wherein the at least one polyol has an average OH functionality from 2 to 8, preferably from 2 to 6, more preferably from 2 to 4.
• the invention relates to the isocyanate-terminated prepolymer according to any one of the preceding embodiments, wherein the isocyanate- terminated prepolymer has a monomeric diisocyanate content of ⁇ 0.1 % by weight.
• the invention relates to the isocyanate-terminated prepolymer according to any one of the preceding embodiments, wherein the isocyanate- terminated prepolymer contains urethane groups and/or allophanate groups and optionally functional groups selected from the group consisting of urea groups, biuret groups, uretdione groups, carbodiimide groups, uretonimine groups, isocyanurate groups and any combination thereof.
• the invention relates to the isocyanate-terminated prepolymer according to any one of the preceding embodiments, wherein the isocyanate- terminated prepolymer is the reaction product of
• At least one monomeric diisocyanate wherein the at least one monomeric diisocyanate and the at least one polyol are used in an amount such that the NCO/OH equivalent ratio is from 1.5:1 to 25:1 , preferably from 2:1 to 20:1.
• the invention relates to the isocyanate-terminated prepolymer according to any one of the preceding embodiments, wherein the at least one monomeric diisocyanate is an aliphatic diisocyanate and/or a cycloaliphatic diisocyanate.
• the invention relates to the isocyanate-terminated prepolymer according to embodiment ten or eleven, wherein the cycloaliphatic diisocyanate is selected from the group consisting of isophorone diisocyanate, 1-isocyanato-4-[(4-isocyanatocyclohexyl)methyl]cyclohexane (H12MDI), 1 ,3-bis(isocyanatomethyl)cyclohexane and mixtures thereof.
• the invention relates to the isocyanate-terminated prepolymer according to any one of the preceding embodiments, wherein the diisocyanate is selected from the group consisting of 1 ,5-diisocyanatopentane, 1 ,6-diisocyanatohexane, isophorone diisocyanate and mixtures thereof.
• the invention relates to a process for preparing the isocyanate-terminated prepolymer according to any one of the preceding embodiments, comprising the following steps a) mixing at least one polyol with an excess of at least one monomeric diisocyanate, b) optionally partly or fully allophanatizing the urethane groups by further reaction with at least one monomeric diisocyanate (which may be different from those from (a)), c) removal of the excess of the monomeric diisocyanate, if present, by distillation down to ⁇ 0.2 % by weight, preferably down to ⁇ 0.1 % by weight, based on the NCO- terminated prepolymer, to obtain the isocyanate-terminated prepolymer, and d) optionally addition of at least one solvent inert towards isocyanate groups.
• the invention relates to the process according to embodiment fourteen, comprising the following steps a) mixing at least one polyol with an excess of at least one monomeric diisocyanate, b) partly or fully allophanatizing the urethane groups by further reaction with at least one monomeric diisocyanate (which may be different from those from (a)), c) removal of the excess of the monomeric diisocyanate, if present, by distillation down to ⁇ 0.2 % by weight, preferably down to ⁇ 0.1 % by weight, based on the NCO- terminated prepolymer, to obtain the isocyanate-terminated prepolymer, and d) optionally addition of at least one solvent inert towards isocyanate groups.
• the invention relates to a use of the isocyanate- terminated prepolymer according to any one of the embodiments one to thirteen or obtained with the process according to embodiment fourteen or fifteen as an isocyanate-terminated prepolymer with reduced skin sensitization potential or no skin sensitization potential.
• the invention relates to a use of the isocyanate- terminated prepolymer according to any one of the embodiments one to thirteen or obtained with the process according to embodiment fourteen or fifteen in curable compositions for a coating system, an adhesive system, a sealant system and/or a foam system, in particular those systems which are applied manually.
• the invention relates to the use according to embodiment seventeen for reducing the skin sensitisation of a coating system, an adhesive system, a sealant system and/or a foam system, in particular for reducing the skin sensitisation of a coating system, an adhesive system, a sealant system and/or a foam system that is applied manually.
• the invention relates to the use according to embodiment seventeen or eighteen, wherein the coating system is a refinish coating system, in particular an automotive refinish coating system.
• the invention relates to the use according to embodiment seventeen or eighteen, wherein the curable composition is applied in a sealant and/or a foam system, in particular in a sealant and/or a foam system that is applied in the building industry.
• the invention relates to a coating, adhesive, sealant or foam system in particular for manual application comprising the isocyanate-terminated prepolymer according to any one of the embodiments one to thirteen or obtained with the process according to embodiments fourteen or fifteen.
• the invention relates to a two-component system according to embodiment twenty-two, characterized in that the two-component system is a refinish coating system, in particular an automotive refinish system.
• the invention relates to a moisture-curable one- component system comprising at least one isocyanate-terminated prepolymer according to any one of the embodiments one to thirteen or obtained with the process according to embodiments fourteen or fifteen.
• the invention relates to a moisture-curable one- component system according to embodiment twenty-five, wherein the one-component system is a one-component foam system, in particular a one-component foam system for application in the building industry.
• Desmodur® I (monomeric aliphatic di isocyanate), Covestro Germany.
• Polyetherpolyol based on propylene oxide and propylene glycol Polyetherpolyol based on propylene oxide and propylene glycol.
• Linear polyetherpolyol based on propylene oxide and propylene glycol.
• Linear polyetherpolyol based on propylene oxide and propylene glycol.
• Polyesterpolyol based on monoethylene glycole and phthalic anhydride.
• Linear polyetherpolyol based on propylene oxide and propylene glycol.
• Linear polyesterpolyol based on neopentyl glcol, monoethylene glycol and adipic acid.
• Branched polyester based on trimethylolpropane, neopentyl glycol, 1,3-butanediol and isophthalic acid were removed by distillation at 195 °C.
• Branched polyether based on glyercol and propylene oxide Branched polyether based on glyercol and propylene oxide.
• Linear polyetherpolyol based on propylene glycole and propylene oxide.
• the NCO contents were determined by titrimetry as per DIN EN ISO 11909:2007-05.
• the residual diisocyanate monomer contents were measured to DIN EN ISO 10283:2007-11 by gas chromatography with an internal standard.
• the functional group equivalent weight refers to the number average molecular weight per isocyanate functional group, and is a value obtained by dividing the number average molecular weight (M n ) of the isocyanate terminated prepolymer, obtained via Gelpermeation Chromatography, by the average number of isocyanate groups per molecule (NCO functionality).
• the NCO functionality of the prepared urethane prepolymer equals the OH functionality of the polyol used as raw material.
• the OH functionality of the polyol is given by the supplier of the polyol and can be determined by the functionality of the components used to prepare the polyol.
• the modified Direct Peptide Reactivity Assays test was done according to the OECD guideline 442C (OECD (2021), Test No. 442C: In Chemico Skin Sensitisation: Assays addressing the Adverse Outcome Pathway key event on covalent binding to proteins, OECD Guidelines for the Testing of Chemicals, Section 4, OECD Publishing, Paris, https://doi.org/10.1787/9789264229709-en). Only the lysine depletion was tested. The test determines the depletion of a synthetic peptide containing lysine due to the reaction with the potential skin sensitizer. The lysine depletion in percent is the loss of lysine containing peptide, determined by HPLC/UV, compared with the control.
• the potential skin sensitizer is the low monomer isocyanate terminated prepolymer or a diisocyanate, that might be present in the low monomer isocyanate terminated prepolymer as residual diisocyanate after the thin-film-distillation.
• LLNA Local Lymph Node Assay
• IMDS modified Local Lymph Node Assays
• IMDS Integrated Model for the Differentiation of Skin reactions
• LLNA classical LLNA
• the modifications in the IMDS (Integrated Model for the Differentiation of Skin reactions) in comparison to the classical LLNA refer to the measurement of cell proliferation by cell counting instead of radioactive labeling.
• the acute inflammatory skin reaction ear swelling I ear weight
• OECD TG 429 is determined to discriminate specific from non-specific activation of immune competent cells in the draining lymph nodes, as also recommended in the update of OECD TG 429.
• test items in formulation, or the vehicle are applied epicutaneously onto the dorsal part of both ears of the animals. This treatment is repeated on three consecutive days (d1 , d2 and d3).
• the volume administered is 25 pl/ear.
• the animals are anaesthetized by inhalation of carbon dioxide and sacrificed one day after the last application (day 4). The appropriate organs are then removed.
• the lymphatic organs (the auricular lymph nodes) are transferred into physiological saline (PBS).
• the weight and cell count determinations are carried out by appropriate laboratory procedures.
• the so-called stimulation (or LLN-) index is calculated by dividing the absolute number of weight or cell counts of the substance treated lymph nodes by the vehicle treated ones.
• the thickness of both auricles of the animals is measured using a spring-loaded micrometer.
• the corresponding index is calculated by dividing the ear thickness of the substance treated ears by that of the ears treated with the vehicle.
• the ear weight of the sacrificed animals is measured using a punch to take a piece of every ear with a diameter of 8 mm.
• the corresponding index is calculated by dividing the ear weight of the substance treated ears by that of the ears treated with the vehicle.
• a compound has a negative Local Lymph Node Assay (LLNA) when the compound has a Stimulation Index (SI value) of less than 3.
• SI value Stimulation Index
• a compound having a SI value of less than 3 is considered negative for skin sensitisation.
• a 5 to 15 fold excess of monomeric diisocyanate is heated to 70 °C to 100 °C under nitrogen.
• the respective polyol(s) are preheated to 60 °C to 80 °C if necessary and added sequentially under stirring to the monomeric diisocyanate via a dropping funnel.
• the mixture is stirred at 70°C to 100 °C until the NCO content was indicative of a complete urethanization.
• excess monomeric diisocyanate is removed via thin film evaporation at a temperature of 110 °C to 185 °C and a pressure of 0.2-0.5 mbar.
• the product obtained is a N CO-terminated urethane prepolymer having analytical characteristics as listed in Table 1a and Table 1b.
• An 5 to 15 fold excess of monomeric aliphatic or cycloaliphatic diisocyanate is heated to 100 °C under nitrogen.
• the respective polyol is preheated to 80 °C if necessary and added under stirring to the monomeric diisocyanate via a dropping funnel.
• the mixture is stirred at 100 °C till the NCO content was indicative of a complete urethanization.
• 100 ppm catalyst is added as a 10 w% solution in 2-ethylhexanol to the mixture.
• the mixture is stirred at 90 °C to 110 °C until the final NCO content is reached.
• Comparative Experiments A-G show a lysine mean depletion of > 1 , leading to the conclusion that prepolymers having a functional group equivalent weight (FGEW) of ⁇ 560 g/mol or a monomeric diisocyanate content of > 0.2% (see comparative example G) independent of the FGEW will result in causing lysine mean depletion > 1 in the described modified Direct Peptide Reactivity assay.
• Inventive examples 1 to 7 having FGEW > 560 g/mol and monomeric diisocyanate content ⁇ 0.2% show lysine mean depletion ⁇ 1.
• Table 1b also shows that this behaviour is independent of the species of diisocyanate used.

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