WO2023127967A1 - 液体入り組合せ容器、検査方法及び液体入り組合せ容器の製造方法 - Google Patents

液体入り組合せ容器、検査方法及び液体入り組合せ容器の製造方法 Download PDF

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Publication number
WO2023127967A1
WO2023127967A1 PCT/JP2022/048666 JP2022048666W WO2023127967A1 WO 2023127967 A1 WO2023127967 A1 WO 2023127967A1 JP 2022048666 W JP2022048666 W JP 2022048666W WO 2023127967 A1 WO2023127967 A1 WO 2023127967A1
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WO
WIPO (PCT)
Prior art keywords
container
oxygen
barrier
liquid
fluorescent material
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2022/048666
Other languages
English (en)
French (fr)
Japanese (ja)
Inventor
和正 八巻
琢磨 馬塲
公一 辰巳
倫子 熊澤
紀子 中田
正敏 黒田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dai Nippon Printing Co Ltd
Original Assignee
Dai Nippon Printing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dai Nippon Printing Co Ltd filed Critical Dai Nippon Printing Co Ltd
Priority to CA3253697A priority Critical patent/CA3253697A1/en
Priority to EP22916189.8A priority patent/EP4458725A4/en
Priority to CN202280086504.2A priority patent/CN118488920A/zh
Priority to US18/724,849 priority patent/US20250058955A1/en
Priority to JP2023571233A priority patent/JP7486064B2/ja
Publication of WO2023127967A1 publication Critical patent/WO2023127967A1/ja
Priority to JP2024074477A priority patent/JP2024109625A/ja
Anticipated expiration legal-status Critical
Priority to JP2025265807A priority patent/JP2026062747A/ja
Ceased legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D77/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
    • B65D77/04—Articles or materials enclosed in two or more containers disposed one within another
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators
    • B65D81/266—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators for absorbing gases, e.g. oxygen absorbers or desiccants
    • B65D81/268—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators for absorbing gases, e.g. oxygen absorbers or desiccants the absorber being enclosed in a small pack, e.g. bag, included in the package
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1468—Containers characterised by specific material properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B57/00—Automatic control, checking, warning, or safety devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D77/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
    • B65D77/04—Articles or materials enclosed in two or more containers disposed one within another
    • B65D77/0406—Rigid containers in preformed flexible containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D79/00—Kinds or details of packages, not otherwise provided for
    • B65D79/02—Arrangements or devices for indicating incorrect storage or transport
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators
    • B65D81/266—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators for absorbing gases, e.g. oxygen absorbers or desiccants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6432—Quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7786—Fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7796—Special mountings, packaging of indicators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence

Definitions

  • the present disclosure relates to a liquid-filled combination container, an inspection method, and a liquid-filled combination container manufacturing method.
  • a container for containing liquid is known (for example, Patent Document 1).
  • oxygen will decompose the liquid in the container.
  • the oxygen concentration within the container and the oxygen concentration of the liquid contained in the container can be reduced by nitrogen bubbling.
  • the present disclosure aims to test the oxygen concentration of a container containing liquid without opening the container.
  • a first liquid-filled combination container comprises: a container containing a liquid in the container and having oxygen permeability; a barrier container containing the container and having an oxygen barrier property; at least one oxygen reactant capable of reacting with oxygen in the barrier container; and a fluorescent material with different fluorescence time or fluorescence intensity depending on the ambient oxygen concentration, the oxygen reactive agent is fixed to at least one of the outer surface of the container and the inner surface of the barrier container;
  • the fluorescent material is provided on the inner surface of the storage portion of the container at a position where the fluorescent material is installed away from the contact area that contacts the liquid,
  • the container has optical transparency at least at the position where the fluorescent material is installed,
  • the barrier container has a light transmission position having light transparency, By allowing the light to pass through the light transmission position of the barrier container and the fluorescent material installation position of the container, the fluorescent material can be irradiated with light from the outside of the barrier container.
  • a second liquid-filled combination container comprises: a container containing a liquid in the container and having oxygen permeability; a barrier container containing the container and having an oxygen barrier property; at least one oxygen reactant capable of reacting with oxygen in the barrier container; and a fluorescent material with different fluorescence time or fluorescence intensity depending on the ambient oxygen concentration,
  • the fluorescent material is provided on the inner surface of the storage portion of the container at a position where the fluorescent material is installed away from the contact area that contacts the liquid,
  • the container has optical transparency at least at the position where the fluorescent material is installed,
  • the barrier container has a light transmission position having light transparency,
  • An oxygen reactant containing portion for containing the oxygen reactant is defined in a part of the barrier container, The oxygen reactant is accommodated in the oxygen reactant accommodating portion so that it is arranged at a position that is not sandwiched between the fluorescent material installation position and the light transmission position.
  • the barrier container may contact the outer surface of the container at the fluorescent material installation position.
  • the container has a coating layer that forms the inner surface of the container and suppresses adhesion of the liquid to the inner surface of the container.
  • the containers may include at least one of glass and cyclic olefin polymer.
  • the first and second liquid-filled combination containers according to an embodiment of the present disclosure further comprise an adhesive layer that adheres the fluorescent material to the inner surface of the container at the position where the fluorescent material is installed and has optical transparency,
  • the adhesive layer may contain at least one resin selected from the group consisting of photocurable acrylic resins, photocurable silicone resins, and epoxy resins.
  • the barrier container may contain at least one of acrylic resin and polyethylene terephthalate resin.
  • the barrier container has flexibility so that it can be deformed so as to come into contact with the outer surface of the container at the position where the fluorescent material is installed. good too.
  • a third liquid-filled combination container comprises: a container containing a liquid in the container and having oxygen permeability; a barrier container containing the container and having an oxygen barrier property; at least one oxygen reactant capable of reacting with oxygen in the barrier container; the oxygen reactive agent is fixed to at least one of the outer surface of the container and the inner surface of the barrier container; the container has a first position and a second position away from a contact area in contact with the liquid of the container; the oxygen reactant is spaced apart from a straight line connecting the first position and the second position; the container is light transmissive at least at the first position and the second position;
  • the barrier container has optical transparency at least at a position intersecting a straight line connecting the first position and the second position.
  • a fourth liquid-filled combination container comprises: a container containing a liquid in the container and having oxygen permeability; a barrier container containing the container and having an oxygen barrier property; at least one oxygen reactant capable of reacting with oxygen in the barrier container; the container has a first position and a second position away from a contact area in contact with the liquid of the container; the oxygen reactant is spaced apart from a straight line connecting the first position and the second position; the container is light transmissive at least at the first position and the second position;
  • the barrier container has optical transparency at least at a position intersecting a straight line connecting the first position and the second position, An oxygen reactant containing portion for containing the oxygen reactant is defined in a part of the barrier container, The oxygen reactant is accommodated in the oxygen reactant accommodating portion, thereby being arranged at a position separated from a straight line connecting the first position and the second position.
  • the barrier container may contact the outer surfaces of the containers at the first position and the second position.
  • the third and fourth liquid-filled combination containers further comprise an outer container that houses the barrier container,
  • the outer container may have a light transmitting portion that intersects a straight line connecting the first position and the second position and transmits light.
  • the container may be fixed to the barrier container.
  • the positional relationship between the container and the oxygen reactant may be determined.
  • the container has a container body having an opening and a stopper closing the opening
  • the plug has oxygen permeability
  • the plug includes a first surface facing the container body and a second surface located on the opposite side of the first surface
  • the oxygen reactive agent may be located on the second side of the plug.
  • a fifth liquid-filled combination container comprises: a container containing a liquid in the container and having oxygen permeability; a barrier container containing the container and having an oxygen barrier property; at least one oxygen reactant capable of reacting with oxygen in the barrier container; and a fluorescent material with different fluorescence time or fluorescence intensity depending on the ambient oxygen concentration,
  • the fluorescent material is provided on the inner surface of the storage portion of the container at a position where the fluorescent material is installed away from the contact area that contacts the liquid,
  • the container has optical transparency at least at the position where the fluorescent material is installed,
  • the barrier container has a light transmission position having light transparency, the oxygen reactant is held in a holding space formed between a portion of the outer surface of the container and a portion of the inner surface of the barrier container; The holding space is not positioned between the fluorescent material installation position and the light transmission position.
  • a sixth liquid-filled combination container comprises: a container containing a liquid in the container and having oxygen permeability; a barrier container containing the container and having an oxygen barrier property; at least one oxygen reactant capable of reacting with oxygen in the barrier container; the container has a first position and a second position away from a contact area in contact with the liquid of the container; the container is light transmissive at least at the first position and the second position;
  • the barrier container has optical transparency at least at a position intersecting a straight line connecting the first position and the second position, the oxygen reactant is held in a holding space formed between a portion of the outer surface of the container and a portion of the inner surface of the barrier container; A straight line connecting the first position and the second position does not pass through the holding space.
  • the container has a container body having an opening, and a lid portion including a plug that closes the opening
  • the container body includes a head portion forming the opening, a neck portion connected to the head portion, and a trunk portion having a width greater than that of the neck portion in a direction orthogonal to an axial direction in which the axis of the container extends.
  • a shoulder connecting the neck and the torso The first position and the second position may be located at the neck.
  • the container is located at a third position and a position separate from the contact area of the container that contacts the liquid and different from the first position and the second position. having a fourth position; the container is light transmissive at least at the third position and the fourth position; The barrier container may have optical transparency at least at a position intersecting a straight line connecting the third position and the fourth position.
  • the length of a line segment located in the container on a straight line connecting the first position and the second position is Equal to the length of a line segment located in the container on a straight line connecting the fourth position, A total length of a line segment located in the space between the container and the barrier container on a straight line connecting the first position and the second position connects the third position and the fourth position. It may be equal to the sum of the lengths of line segments located in the space between the container and the barrier container in a straight line.
  • the barrier container comprises a circumferentially continuous first contact area around the axis of the container, and a circumferentially continuous first contact area around the axis of the container, and in contact with the container in a second contact area facing the first contact area across the the first position and the third position are located on the first contact area;
  • the second position and the fourth position may be located on the second contact area.
  • the container has a container body having an opening, and a lid portion including a plug that closes the opening
  • the barrier container comprises a first film constituting a first surface of the barrier container, a second film constituting a second surface of the barrier container facing the first surface, the first film and the A bag for accommodating the container between the first film and the second film, the bag having a sealing portion that joins the first film and the second film in at least a part of the second film There may be.
  • the sealing portion separates the first film and the second film along the entire in-plane direction of the first film and the second film. May be joined.
  • the seal portion includes a first side seal portion and a second side seal facing each other in a direction orthogonal to an axial direction in which the axis of the container extends. has a part From the distance between the first side seal portion and the second side seal portion, 1/4 of the length of the entire circumference of the container in the circumferential direction around the axis was subtracted and multiplied by 0.8. The length may be smaller than the maximum width in a direction orthogonal to the thickness direction of the oxygen reactant.
  • the distance between the first film and the lid and the distance between the second film and the lid are equal to the oxygen reactant may be smaller than the width in the thickness direction.
  • the container body includes a head portion forming the opening, a neck portion connected to the head portion, and an axial direction extending along the axis of the container. a body portion having a width greater than that of the neck portion in a direction orthogonal to the body portion; and a shoulder portion connecting the neck portion and the body portion; The distance between the first film and the shoulder and the distance between the second film and the shoulder may be smaller than the width of the oxygen reactant in the thickness direction.
  • the barrier container has a barrier container in which portions not joined by the sealing portion that joins the first film and the second film are in close contact with each other. Having a first contact region and a second contact region, The first contact area and the second contact area may be formed at positions sandwiching the container in a direction orthogonal to an axial direction in which an axis of the container extends.
  • At least a portion of the first contact region and the second contact region may overlap a portion of the oxygen reactant in the axial direction.
  • the oxygen reactant is an oxygen absorber that absorbs oxygen in the barrier container, or a It may be an oxygen detecting material that detects.
  • a first inspection method includes: An inspection method for inspecting the oxygen concentration in the liquid-filled combination container described above, Light that causes the fluorescent material to fluoresce is transmitted through the light transmission position of the barrier container and the fluorescent material installation position of the container and irradiated to the fluorescent material, and the fluorescence time or fluorescence intensity of the fluorescent material is measured. a fluorescence measurement step to a measuring step of measuring the oxygen concentration in the container based on the fluorescence time or fluorescence intensity of the fluorescent material measured in the fluorescence measuring step.
  • the barrier container contacts the outer surface of the container at the position where the fluorescent material is installed.
  • the fluorescent material is irradiated with the light that causes the fluorescent material to fluoresce through the fluorescent material-installed position of the container and the portion of the barrier container that contacts the fluorescent material-installed position.
  • the fluorescence time or fluorescence intensity of the fluorescent material may be measured.
  • an illumination unit that emits light that causes the fluorescent material to fluoresce; and a sensor unit that measures the fluorescence time or fluorescence intensity of the fluorescent material.
  • the detection device having The sensor unit may be used to measure the fluorescence time or fluorescence intensity of the fluorescent material.
  • the barrier container has flexibility so as to be deformable so as to come into contact with the outer surface of the container at the position where the fluorescent material is installed
  • the method may further include the step of bringing the detection device into contact with the barrier container, and pushing the barrier container with the detection device to contact the outer surface of the container at the fluorescent material installation position.
  • a second inspection method includes: An inspection method for inspecting the oxygen concentration in the liquid-filled combination container described above, laser light or LED light having a wavelength that is attenuated according to the oxygen concentration in the optical path is transmitted through the light-transmitting position of the barrier container and the first and second positions of the container; an attenuation rate measuring step of irradiating a liquid-filled combination container to measure the attenuation rate of the laser light or the LED light; a measuring step of measuring the oxygen concentration in the container based on the attenuation rate measured in the attenuation rate measuring step.
  • the liquid-filled combination container may be irradiated with the laser light or the LED light so as to pass through the first position and the second position of the container.
  • a second inspection method may further include the step of bringing the barrier container into contact with the outer surfaces of the container at the first position and the second position.
  • the wavelength of the laser light or the LED light may include a wavelength of 760 nm.
  • the laser beam or the a second standard sample measuring step of measuring the attenuation rate of the laser light or the LED light by irradiating the LED light so as to pass through the interior of the container In the measuring step, the relationship between the attenuation rate measured in the first standard sample measuring step and the oxygen concentration inside the container in the first standard sample, and the attenuation rate measured in the second standard sample measuring step calculating the oxygen concentration in the container of the combination container containing the liquid from the attenuation rate measured in the attenuation rate measurement step, based on the relationship between the second standard sample and the oxygen concentration inside the container include.
  • the liquid-filled combination container when the liquid-filled combination container is irradiated with the laser light or the LED light in the attenuation rate measuring step, the The barrier container, the light source for irradiating the laser light or the LED light, and the measuring device for measuring the attenuation rate of the laser light or the LED light are placed in the same manner as the placement of the first standard sample with respect to the container.
  • the barrier container, the light source, and the measuring device with respect to the container, and irradiating the first standard sample with the laser light or the LED light;
  • the barrier container, the light source, and the measuring device against the container when the liquid-filled combination container is irradiated with the laser light or the LED light in the attenuation rate measuring step arranging the barrier container of the second standard sample, the light source, and the measuring device with respect to the container of the second standard sample so as to be the same as the arrangement, and applying the laser to the second standard sample You may irradiate with light or said LED light.
  • a third inspection method includes a container containing a liquid in a container and having oxygen permeability, a barrier container containing the container and having oxygen barrier properties, and A method for inspecting a liquid-filled combination container comprising at least one oxygen-reactive agent capable of reacting with oxygen in the container, and a fluorescent material whose fluorescent time or fluorescent intensity varies depending on the ambient oxygen concentration, comprising:
  • the fluorescent material is provided on the inner surface of the storage portion of the container at a position where the fluorescent material is installed away from the contact area that contacts the liquid,
  • the container has optical transparency at least at the position where the fluorescent material is installed,
  • the barrier container has a light transmission position having light transparency, an arrangement step of arranging the oxygen reactive agent so as not to be positioned between the fluorescent material installation position and the light transmission position;
  • Light that causes the fluorescent material to fluoresce is transmitted through the light transmission position of the barrier container and the fluorescent material installation position of the container and irradiated to the fluorescent material, and the fluorescence time or fluorescence intensity of the fluorescent material
  • a fourth inspection method includes a container containing a liquid in a container and having oxygen permeability; a barrier container containing the container and having oxygen barrier properties; at least one oxygen-reactive agent capable of reacting with oxygen in the container, comprising: the container has a first position and a second position away from a contact area in contact with the liquid of the container; the container is light transmissive at least at the first position and the second position;
  • the barrier container has optical transparency at least at a position intersecting a straight line connecting the first position and the second position, an arrangement step of arranging the oxygen reactant at a position spaced apart from a straight line connecting the first position and the second position; laser light or LED light having a wavelength that is attenuated according to the oxygen concentration in the optical path is transmitted through the light-transmitting position of the barrier container and the first and second positions of the container; an attenuation rate measuring step of irradiating a liquid-filled combination container to measure the attenuation rate of the laser light or the LED light
  • the container is placed at third and fourth positions away from a contact area in contact with the liquid of the container and different from the first and second positions.
  • has a position the container is light transmissive at least at the third position and the fourth position;
  • the barrier container has optical transparency at least at a position intersecting a straight line connecting the third position and the fourth position, an additional placement step of placing the oxygen reactant at a position spaced apart from a straight line connecting the third position and the fourth position; laser light or LED light having a wavelength that is attenuated according to the oxygen concentration in the optical path is transmitted through the light-transmissive position of the barrier container and the third and fourth positions of the container; an additional attenuation rate measuring step of irradiating the liquid-filled combination container to measure the attenuation rate of the laser light or the LED light; an additional measurement step of measuring the oxygen concentration in the container based on the attenuation rate measured in the additional attenuation rate measurement step;
  • the length of a line segment located in the container on a straight line connecting the first position and the second position is equal to the length of the line segment located within the vessel on a straight line connecting the A total length of a line segment located in the space between the container and the barrier container on a straight line connecting the first position and the second position connects the third position and the fourth position. It may be equal to the sum of the lengths of line segments located in the space between the container and the barrier container in a straight line.
  • the fourth inspection method further comprising a contacting step of contacting the barrier container with the outer surface of the container,
  • the barrier container is provided with a first contact region continuous in the circumferential direction around the axis of the container, and a second contact region continuous in the circumferential direction and facing the first contact region across the axis. 2 contacting with the container at the contact area; the first position and the third position are located on the first contact area; The second position and the fourth position may be located on the second contact area.
  • a fourth inspection method on a virtual plane perpendicular to the axis and passing through the first contact area and the second contact area, An angle formed by a straight line connecting one end of the first contact region in the circumferential direction and the axis and a straight line connecting the other end of the first contact region in the circumferential direction and the axis , 120° or more, An angle formed by a straight line connecting one end of the second contact area in the circumferential direction and the axis and a straight line connecting the other end of the second contact area in the circumferential direction and the axis , 120° or more.
  • the barrier container comprises a first film constituting a first surface of the barrier container and a second film facing the first surface of the barrier container. and a sealing portion that joins the first film and the second film in at least a part of the first film and the second film, and the first film and the A bag that accommodates the container between the second film, further comprising a contacting step of contacting the barrier container with the outer surface of the container at the first position and the second position; In the contacting step, a first tensile region of the barrier container that does not overlap the container when viewed in plan view from the thickness direction of the first film, and a first tensile region that does not overlap the container when viewed in plan view from the thickness direction of the first film
  • the barrier container may be brought into contact with outer surfaces of the container at the first and second locations by pulling the first and opposing second tension regions away from each other. .
  • a fourth inspection method further comprising a contacting step of contacting the barrier container with the outer surface of the container at the first position and the second position,
  • the barrier container may be brought into contact with the outer surfaces of the container at the first position and the second position by a pushing member that pushes the barrier container from the outside and contacts the outer surface of the container.
  • the container has a container body having an opening and a lid including a plug that closes the opening,
  • the container body includes a head portion forming the opening, a neck portion connected to the head portion, and a trunk portion having a width greater than that of the neck portion in a direction orthogonal to an axial direction in which the axis of the container extends.
  • a shoulder connecting the neck and the torso The first position and the second position may be located at the neck.
  • the oxygen concentration in the container is measured by the inspection method described above, and the an obtaining step of obtaining a first oxygen concentration, which is the oxygen concentration in the container at one time, and a second oxygen concentration, which is the oxygen concentration in the container at the second time;
  • the second oxygen concentration is 100 times or more the measurement limit and 0.99 times or more and 1.01 times or less the first oxygen concentration, or the second oxygen concentration is the measurement limit or more and less than 100 times the measurement limit.
  • the obtaining step may include vibrating the container at a time between the first time and the second time.
  • the obtaining step may include determining whether the oxygen concentration in the barrier container is equal to or less than a target value.
  • the oxygen concentration in the container is measured by the inspection method described above at the first measurement time and the second measurement time after the first measurement time. , acquiring the oxygen concentration in the container at the first measurement time and the oxygen concentration in the container at the second measurement time; Based on the oxygen concentration in the container at the first measurement time, specify the oxygen saturation solubility in the liquid contained in the container at the first measurement time, and based on the specified oxygen saturation solubility, the first identifying a first dissolved oxygen amount, which is the dissolved oxygen amount of the liquid at the measurement time; Based on the oxygen concentration in the container at the second measurement time, specify the oxygen saturation solubility in the liquid contained in the container at the second measurement time, and based on the specified oxygen saturation solubility, the second a step of specifying a second dissolved oxygen amount, which is the dissolved oxygen amount of the liquid at the measurement time; a step of calculating a decreasing rate of the dissolved oxygen amount of the liquid based on the first dissolved oxygen amount and the second dissolved
  • a method for manufacturing a first liquid-filled combination container comprises: An inspection step of inspecting the liquid-filled combination container by the inspection method described above is provided.
  • a seventh liquid-filled combination container comprises: a container containing a liquid in the container and having oxygen permeability; a barrier container containing the container and having an oxygen barrier property; at least one oxygen reactant capable of reacting with oxygen in the barrier container; and a fluorescent material with different fluorescence time or fluorescence intensity depending on the ambient oxygen concentration, the oxygen reactive agent is fixed to at least one of the outer surface of the container and the inner surface of the barrier container;
  • the fluorescent material is provided on the inner surface of the barrier container fluorescent material installation position of the barrier container,
  • the barrier container has optical transparency at least at the location where the fluorescent material is installed in the barrier container, Light can be irradiated to the fluorescent material from the outside of the barrier container by passing through the barrier container fluorescent material installation position of the barrier container.
  • a fifth inspection method includes: An inspection method for inspecting the oxygen concentration of the barrier container of the liquid-filled combination container described above, Barrier container fluorescence for measuring the fluorescence time or fluorescence intensity of the fluorescent material by irradiating the fluorescent material with light that causes the fluorescent material to fluoresce through the barrier container fluorescent material installation position of the barrier container. a measuring step; a barrier property container measuring step of measuring the oxygen concentration in the barrier property container based on the fluorescence time or fluorescence intensity of the fluorescent material measured in the barrier property container fluorescence measurement step.
  • An eighth liquid-filled combination container comprises: a container containing a liquid in the container and having oxygen permeability; a barrier container containing the container and having an oxygen barrier property; at least one oxygen reactant capable of reacting with oxygen in the barrier container; the oxygen reactive agent is fixed to at least one of the outer surface of the container and the inner surface of the barrier container;
  • the barrier container has a barrier container first position and a barrier container second position, the oxygen reactant and the container are separated from a straight line connecting the first position of the barrier container and the second position of the barrier container;
  • the barrier container has optical transparency at least at the barrier container first position and the barrier container second position.
  • a sixth inspection method includes: An inspection method for inspecting the oxygen concentration in the barrier container of the liquid-filled combination container described above,
  • the liquid-filled combination container is configured to transmit laser light or LED light having a wavelength that is attenuated according to the oxygen concentration in the optical path through the barrier container first position and the barrier container second position of the barrier container.
  • the oxygen concentration of a container containing liquid can be inspected without opening the container.
  • FIG. 1 is a diagram for explaining the first embodiment of the present disclosure, and is a perspective view showing an example of a liquid-filled combination container.
  • 2 is a longitudinal cross-sectional view showing a liquid-filled container that can be included in the liquid-filled combination container of FIG. 1;
  • FIG. 3 is a longitudinal cross-sectional view showing a method of measuring oxygen transmission through a portion of the container shown in FIG. 2;
  • FIG. 4 is a perspective view showing another example of the barrier container.
  • FIG. 5 is a perspective view showing still another example of the barrier container.
  • FIG. 6 is a perspective view showing still another example of the barrier container.
  • FIG. 7 is a perspective view showing still another example of the barrier container.
  • FIG. 8 is a cross-sectional view showing a deformed barrier container in the liquid-filled combination container of FIG. 1.
  • FIG. FIG. 9 is a cross-sectional view showing an example of a deoxidizer.
  • FIG. 10 is a cross-sectional view showing an example of a deoxidizing film containing a deoxidizing agent.
  • 11A and 11B are diagrams illustrating an example of a method of manufacturing the liquid-filled combination container of FIG. 1 and the liquid-filled container of FIG. 12 is a perspective view showing how to use the liquid-filled container of FIG. 2.
  • FIG. 13A and 13B are diagrams showing an example of an inspection method for a liquid-filled combination container according to Modification 1.
  • FIG. 14A and 14B are diagrams showing another example of the inspection method for the liquid-filled combination container according to Modification 1.
  • FIG. FIG. 15 is a cross-sectional view showing a liquid-filled combination container of Modification 2.
  • FIG. 16 is a cross-sectional view showing a liquid-filled combination container of Modification 3.
  • FIG. 17 is a cross-sectional view showing an example of a liquid-filled combination container according to the second embodiment of the present disclosure.
  • FIG. 18 is a cross-sectional view showing another example of the liquid-filled combination container according to the second embodiment of the present disclosure.
  • FIG. 19 is a cross-sectional view showing a liquid-filled combination container of Modification 4.
  • FIG. 15 is a cross-sectional view showing a liquid-filled combination container of Modification 2.
  • FIG. 16 is a cross-sectional view showing a liquid-filled combination container of Modification 3.
  • FIG. 17 is a cross-sectional view showing an example of a liquid-filled combination container according to the second embodiment of the
  • FIG. 20A and 20B are diagrams showing an example of an inspection method for a liquid-filled combination container according to Modification 5.
  • FIG. 21A and 21B are diagrams showing another example of the inspection method for the liquid-filled combination container according to Modification 5.
  • FIG. FIG. 22A is a view showing an example of a liquid-filled combination container of modification 6.
  • FIG. 22B is a diagram showing an example of a liquid-filled combination container of modification 7.
  • FIG. 22C is a diagram showing an example of a liquid-filled combination container of modification 8.
  • FIG. 23A is a view showing an example of a barrier container according to Modification 9.
  • FIG. 23B is a diagram showing an example of a liquid-filled combination container of modification 10.
  • FIG. 23C is a view showing an example of a liquid-filled combination container of modification 10.
  • FIG. 24 is a diagram illustrating an example of an inspection method for a liquid-filled combination container according to the third embodiment of the present disclosure.
  • FIG. 25 is a diagram showing another example of the method for inspecting a liquid-filled combination container according to the third embodiment of the present disclosure.
  • FIG. 26 is a front view showing a liquid-filled combination container according to the fourth embodiment of the present disclosure.
  • FIG. 27 is a cross-sectional view showing a liquid-filled combination container according to a fourth embodiment of the present disclosure.
  • FIG. 28 is a cross-sectional view showing a liquid-filled combination container according to a fourth embodiment of the present disclosure.
  • FIG. 29 is a cross-sectional view showing a liquid-filled combination container according to a fourth embodiment of the present disclosure.
  • FIG. 30 is a cross-sectional view showing a state in which the liquid-filled combination container shown in FIG. 29 is moved inside the barrier container.
  • FIG. 31 is a front view showing an example of a liquid-filled combination container of modification 12.
  • FIG. 32 is a cross-sectional view showing another example of the liquid-filled combination container of the twelfth modification.
  • FIG. 33 is a cross-sectional view showing an example of a liquid-filled combination container of modification 13.
  • FIG. FIG. 34 is a cross-sectional view showing another example of the liquid-filled combination container of the thirteenth modification.
  • FIG. 35 is a cross-sectional view showing a liquid-filled combination container according to a fifth embodiment of the present disclosure.
  • 36A and 36B are diagrams showing an example of the contacting step in the inspection method of Modification 14.
  • FIG. 37A and 37B are diagrams showing an example of the contacting step in the inspection method of Modification 15.
  • FIG. 36A and 36B are diagrams showing an example of the contacting
  • the liquid container 30L includes the container 30 and the liquid L contained in the container 30. As shown in FIG. Container 30 is oxygen permeable. Container 30 includes, at least in part, a portion that is oxygen permeable. The container 30 has an inner surface 30a, which is the surface of the container 30 on which the liquid L is stored, and an outer surface 30b, which is the surface opposite to the inner surface 30a.
  • the liquid-filled combination container 10L includes a liquid-filled container 30L and a barrier container 40 .
  • the barrier container 40 has oxygen barrier properties.
  • the barrier container 40 can accommodate the liquid-filled container 30L. In the liquid-filled combination container 10L, the liquid-filled container 30L is accommodated in the barrier container 40 .
  • the amount of oxygen in the barrier container 40 is adjusted by the oxygen scavenger 21 that absorbs the oxygen in the barrier container 40, and the oxygen concentration in the container 30 is sufficiently increased in a short period of time. can be reduced to
  • the liquid-filled container 30L of the first embodiment includes a fluorescent material 27.
  • the fluorescent material 27 provided in the liquid-filled container 30L differs in fluorescent time or fluorescent intensity depending on the surrounding oxygen concentration.
  • the fluorescence time is the time from when the fluorescent material 27 starts to fluoresce when the fluorescent material 27 is irradiated with light until the fluorescent material 27 quenches.
  • the fluorescence intensity is the fluorescence intensity of the fluorescent material 27 when the fluorescent material 27 is irradiated with light.
  • the fluorescence intensity in particular, the fluorescence intensity at the wavelength at which the fluorescent material 27 exhibits the strongest fluorescence intensity may be used.
  • the fluorescence time of the fluorescent material 27 is shortened when the surrounding oxygen concentration is high, and the fluorescence time is lengthened when the surrounding oxygen concentration is low.
  • the fluorescence intensity of the fluorescent material 27 decreases when the ambient oxygen concentration is high, and increases when the ambient oxygen concentration is low.
  • a fluorescent material 27 is provided on the inner surface 30 a of the container 30 . The oxygen concentration in the container 30 can be inspected by irradiating the fluorescent material 27 with light that causes the fluorescent material 27 to fluoresce and measuring the fluorescence time or fluorescence intensity of the fluorescent material 27 .
  • the liquid container 30L includes the container 30 and the liquid L contained in the container 30.
  • the container 30 has oxygen permeability.
  • the container 30 can seal the liquid L.
  • the container 30 is permeable to oxygen and impermeable to the liquid L.
  • the oxygen-permeable container 30 is an airtight container.
  • An airtight container means a container in which gas leakage is not detected by the immersion method specified in JISZ2330:2012. More specifically, a container that can prevent air bubbles from leaking when a gas-containing container is immersed in water is judged to be an airtight container. An airtight container is judged to be in an airtight state when no air bubbles leak from the container when the container containing the gas is immersed in water. In the liquid immersion test, the container to be tested is immersed to a depth of 10 cm or more and 30 cm or less from the water surface. The presence or absence of air bubbles is determined by visual observation over 10 minutes.
  • the liquid L contained in the container 30 is not particularly limited.
  • Liquid L may be a solution comprising a solvent and a solute dissolved in the solvent.
  • the solvent is not particularly limited.
  • the solvent may be water or alcohol.
  • Liquid L is not limited to a liquid in a strict sense.
  • the liquid L may be a suspension in which solid particles are dispersed.
  • the liquid L as food may be tea, coffee, black tea, soup, juice, soup stock, or a concentrated liquid obtained by concentrating one or more of these.
  • the liquid L as a medicine may be an internal medicine, an external medicine, or an injection. Besides food and medicine, the liquid L may be blood or body fluid.
  • the liquid L is contained in the container 30.
  • a portion of the container 30 in which the liquid L is stored is referred to as a storage portion 31 .
  • the volume of liquid L contained in container 30 is smaller than the volume of container 30 . Therefore, the liquid L comes into contact with part of the storage section 31 .
  • a region of the containing portion 31 that contacts the liquid L in a state where the container 30 is stationary is referred to as a contact region 31a.
  • the state in which the container 30 is left at rest includes a state in which the container 30 is arranged such that the liquid level of the liquid L is stabilized for a predetermined time.
  • the container 30 is designed in advance such that the liquid level of the liquid L is stabilized for a predetermined time by arranging it in a specific orientation.
  • the state in which the container 30 is stationary includes the state in which the container 30 is arranged in the specific orientation.
  • the contact area 31a is the area of the container 31 that comes into contact with the liquid L when the container 30 is upright.
  • the state in which the container 30 is erected is, for example, a state in which the container 30 is stably arranged on a horizontal mounting surface.
  • the upright state of the container 30 means a state in which the opening 33 side of the container body 32 faces upward. good.
  • the state in which the container 30 is left at rest includes the state in which the container 30 is erected. includes the state in which the container 30 is arranged.
  • the state in which the container 30 is left at rest may include a state in which the opening 33 side of the container body 32 faces sideways and a state in which the opening 33 side of the container body 32 faces obliquely upward.
  • the state in which the container 30 is stationary includes a state in which the liquid level of the liquid L is stabilized by supporting the container 30 with the barrier container 40 .
  • the state in which the container 30 is stationary includes a state in which the liquid level of the liquid L is stabilized by supporting the container 30 with a member other than the barrier container 40 .
  • the container 30 when the container 30 is in a stationary state, the container 30 is supported by an intermediate container 50 (to be described later) which contains the container 30 and which is contained in the barrier container 40, so that the liquid level of the liquid L is contains a stabilized state.
  • the state in which the container 30 is left at rest includes a state in which the liquid level of the liquid L is stabilized by supporting the container 30 with an outer container 55 (to be described later) that houses the container 30 and the barrier container 40 .
  • the state in which the container 30 is stationary includes a state in which the liquid level of the liquid L is stabilized by hanging the container 30 .
  • a space in which the gas can be accommodated and which is generated above the contact area 31a that contacts the liquid L in the accommodating portion 31 of the container 30 is referred to as a headspace HS.
  • Liquid L may be any liquid that is to be kept sterile.
  • Liquids L to be kept sterile include highly sensitive liquids such as food and medicines.
  • the highly sensitive liquid L is susceptible to deterioration due to post-sterilization (also called final sterilization) performed after manufacturing.
  • Post-sterilization is not applicable for sensitive liquids. Examples of post-sterilization include sterilization such as high pressure steam method, dry heat method, radiation method, ethylene oxide gas method, and hydrogen peroxide gas plasma method.
  • the highly sensitive liquid L in this specification means that 5% or more of the weight ratio of all active ingredients contained in the liquid is decomposed by post-sterilization of the liquid L, and by post-sterilization of the liquid L It means a liquid in which one or more active ingredients contained in the liquid decompose at a weight ratio of 1% or more.
  • a highly sensitive liquid L that cannot be subjected to post-sterilization can be manufactured using a production line arranged in an aseptic environment. That is, the highly sensitive liquid L can be produced by aseptic procedures. Examples of the highly sensitive liquid L include anticancer agents, antiviral agents, vaccines, antipsychotic agents, and the like.
  • the oxygen content of the liquid L produced by the aseptic method can be adjusted.
  • creating an inert gas atmosphere for the entire space in which the production line for the liquid L is arranged entails a huge capital investment. Therefore, the amount of oxygen in a container containing a highly sensitive liquid has been controlled by replacing the atmosphere in the container with an inert gas, bubbling the liquid L with an inert gas, or the like.
  • the liquid container 30L is housed in the barrier container 40, and the oxygen scavenger 21 that absorbs the oxygen in the barrier container 40 is used.
  • the oxygen concentration in the barrier container 40 can be sufficiently reduced.
  • the oxygen concentration (%) in the container 30 can be sufficiently reduced, and the dissolved oxygen amount (mg/L) in the liquid L can be sufficiently reduced in a short period of time.
  • the oxygen dissolution amount of liquid L can be reduced to less than 0.15 mg/L, 0.04 mg/L or less, 0.03 mg/L or less, 0.02 mg/L or less, and even less than 0.015 mg/L. .
  • liquid L labeled as “sterilized” or “sterile”
  • the inside of the container containing the product, and the product such as pharmaceuticals fall under "sterile conditions” as used herein.
  • the product (liquid L) that satisfies the sterility assurance level (SAL) of 10 -6 specified in JIS T0806: 2014 and the inside of the container containing the product also fall under "sterile” used herein. do.
  • a product that does not grow bacteria after being stored in a refrigerated state (for example, 8° C. or below) for eight weeks or more and the inside of a container containing the product also correspond to “sterile” as used herein.
  • sterile as used herein also applies to a drug that does not allow bacteria to proliferate after being stored at a temperature of 28° C. to 32° C. for 2 weeks, and the inside of a container containing the drug.
  • Container 30 is oxygen permeable.
  • a container having oxygen permeability means that in an atmosphere with a temperature of 23° and a humidity of 40% RH, oxygen permeates the container at a predetermined oxygen permeation amount or more and can move between the inside and the outside of the container. It means that there is
  • the predetermined oxygen permeation amount is 1 ⁇ 10 ⁇ 1 (mL/(day ⁇ atm)) or more.
  • the predetermined oxygen permeation amount may be 1 (mL/(day ⁇ atm)) or more, 1.2 (mL/(day ⁇ atm)) or more, or 5 (mL/(day ⁇ atm)) or more.
  • the amount of oxygen in the container 30 can be adjusted by the oxygen permeation of the container 30 .
  • An upper limit may be set for the amount of oxygen that permeates the container 30 .
  • the amount of oxygen permeation through the container 30 may be 100 (mL/(day x atm)) or less, 50 (mL/(day x atm)) or less, or 10 (mL/(day x atm)) or less. good.
  • the range of the oxygen permeation amount may be determined by combining the above-described arbitrary lower limit of the oxygen permeation amount with the above-described arbitrary upper limit of the oxygen permeation amount.
  • the oxygen permeability coefficient of the material constituting the oxygen-permeable portion of the container 30 may be 1 ⁇ 10 ⁇ 12 (cm 3 (STP) ⁇ cm/(cm 2 ⁇ sec ⁇ Pa)) or more, and may be 5 ⁇ 10 ⁇ It may be 12 (cm 3 (STP) ⁇ cm/(cm 2 ⁇ sec ⁇ Pa)) or more, or may be 1 ⁇ 10 ⁇ 11 (cm 3 (STP) ⁇ cm/(cm 2 ⁇ sec ⁇ Pa)) or more.
  • the oxygen permeability of the container 30 is promoted, and the oxygen concentration in the container 30 can be quickly adjusted.
  • the portion having oxygen permeability includes a plurality of layers
  • the material constituting at least one layer may have the above oxygen permeability coefficient, and the materials constituting all layers have the above oxygen permeability coefficient. You may
  • the oxygen permeability coefficient is a value measured according to JIS K7126-1.
  • the oxygen permeability coefficient is a value measured according to JIS K6275-1.
  • the oxygen permeability coefficient is a value measured using an OXTRAN (2/61) permeation meter manufactured by MOCON, USA, in an environment of temperature 23° C. and humidity 40% RH. .
  • All gases may permeate the container 30 . Only some gases, including oxygen, may be permeable through the container 30 . Only oxygen may be permeable through container 30 .
  • the container 30 may have oxygen permeability by making the entire container 30 permeable to oxygen.
  • the container 30 may be oxygen permeable by making only a portion of the container 30 permeable to oxygen.
  • the container 30 may include a container body 32 and a stopper 34.
  • the container body 32 has an opening 33 .
  • a plug 34 is held in the opening 33 .
  • the plug 34 includes a first surface 34e facing the container body 32 and a second surface 34f located opposite the first surface 34e.
  • the plug 34 contacts the opening 33 on the first surface 34e.
  • a plug 34 closes the opening 33 .
  • plug 34 suppresses leakage of the liquid L from the opening 33 .
  • plug 34 may be oxygen permeable. If the oxygen-permeable portion of the container 30 is not in contact with the liquid L, oxygen permeation through that portion can be promoted.
  • the stopper 34 When the container 30 including the container body 32 and the stopper 34 is in a normal state (a state in which the container 30 is erected as described above), the stopper 34 is separated from the liquid L contained in the container body 32 . That is, in a normal storage state of the container 30, oxygen permeation through the stopper 34 of the container 30 can be promoted. In this regard, by making the plug 34 permeable to oxygen, the amount of oxygen in the container 30 can be rapidly adjusted.
  • the plug 34 having oxygen permeability may be made of a material having the oxygen permeability coefficient (cm 3 (STP) ⁇ cm/(cm 2 ⁇ sec ⁇ Pa)) described above.
  • the oxygen permeability coefficient of the material forming the plug 34 may be greater than the oxygen permeability coefficient of the material forming the container body 32 .
  • a portion of plug 34 may be oxygen permeable.
  • a portion of plug 34 may be oxygen permeable throughout its entire thickness.
  • the plug 34 may be oxygen permeable throughout its entire thickness in a central portion remote from the periphery and oxygen barrier in a peripheral portion surrounding the central portion.
  • the oxygen concentration (%) in the container 30 can be reduced by 5% or more.
  • the configuration of the oxygen permeable portion of container 30 may be determined.
  • the area of the opening 33 that is, the opening area of the container body 32 may be 1 mm 2 or more, 10 mm 2 or more, or 30 mm 2 or more.
  • the thickness of the plug 34 may be 3 mm or less, or 1 mm or less. Oxygen permeation of the container 30 is promoted by these, and oxygen concentration adjustment in the container 30 can be performed rapidly.
  • the needle of the syringe can be pierced through the stopper 34 .
  • the thickness of the stopper for example, the thickness of the film-like stopper is 0.001. It may be several millimeters or less.
  • the area of the opening 33 may be 5000 mm 2 or less.
  • the thickness of the plug 34 may be 0.01 mm or more. As a result, the leakage of water vapor and the like can be suppressed, and the effect on the liquid in the container 30 after the barrier container 40 is opened due to the high oxygen permeation rate can be suppressed.
  • the upper limit of the area of the opening may be combined with any lower limit of the area of the opening described above to define the range of the area of the opening.
  • a range of plug 34 thicknesses may be defined by combining the lower limit of plug 34 thickness with any upper limit of plug 34 thickness described above.
  • the plug 34 having oxygen permeability is not particularly limited, and may have various configurations.
  • plug 34 is inserted into opening 33 of container body 32 to close opening 33 .
  • the plug 34 shown in FIG. 2 includes a plate-like plate-like portion 34a and a cylindrical portion 34b extending from the plate-like portion 34a.
  • the tubular portion 34b is, for example, cylindrical.
  • the tubular portion 34 b is inserted into the opening 33 .
  • the plate-like portion 34a includes a flange portion extending radially outward from the cylindrical portion 34b.
  • a flange portion of the plate-like portion 34 a is placed on the head portion 32 d of the container body 32 .
  • plug 34 may have an outer spiral and an inner spiral.
  • a stopper 34 may be attached to the container body 32 by a helical engagement.
  • the plug 34 may contain silicone.
  • the plug 34 may be made of silicone only. A portion of plug 34 may be formed from silicone.
  • the silicone contained in plug 34 is solid under the environment in which container 30 is intended to be used.
  • the silicone contained in the plug 34 may not contain silicone that becomes liquid at room temperature, such as silicone oil.
  • Silicone is a substance having a siloxane bond as a main chain.
  • Plug 34 may be formed from a silicone elastomer.
  • the plug 34 may be made of silicone rubber.
  • Silicone rubber refers to a rubber-like material made of silicone. Silicone rubber is a synthetic resin containing silicone as a main component, and is a rubber-like substance. Silicone rubber is a rubber-like substance having a siloxane bond as a main chain. A silicone rubber may be a thermosetting compound containing siloxane bonds. Examples of silicone rubber include methylsilicone rubber, vinyl-methylsilicone rubber, phenyl-methylsilicone rubber, dimethylsilicone rubber, and fluorosilicone rubber.
  • the oxygen permeability coefficient of silicone and the oxygen permeability coefficient of silicone rubber may be 1 ⁇ 10 ⁇ 12 (cm 3 (STP) ⁇ cm/(cm 2 ⁇ sec ⁇ Pa)) or more, and may be 1 ⁇ 10 ⁇ 11 (cm 3 ( STP) ⁇ cm/(cm 2 ⁇ sec ⁇ Pa)) or more.
  • the oxygen permeability coefficient of silicone and the oxygen permeability coefficient of silicone rubber may be 1 ⁇ 10 ⁇ 9 (cm 3 (STP) ⁇ cm/(cm 2 ⁇ sec ⁇ Pa)) or less.
  • Silicone and silicone rubber have a hydrogen permeability coefficient about 10 times higher, an oxygen permeability coefficient about 20 times higher, and a nitrogen permeability coefficient about 30 times higher than that of natural rubber. Silicone and silicone rubber have a hydrogen permeability coefficient that is 70 times or more, an oxygen permeability coefficient that is 40 times or more, and a nitrogen permeability coefficient that is 650 times or more as compared to butyl rubber.
  • the plug 34 may be at least partially made of silicone. That is, the plug 34 may be wholly or partially made of silicone or silicone rubber.
  • a portion of plug 34 may be constructed of silicone or silicone rubber over its entire thickness. The portion may be the central portion of the plug 34, or it may be part or all of the peripheral portion surrounding the central portion.
  • the container body 32 may include a bottom portion 32a, a body portion 32b, a neck portion 32c and a head portion 32d in this order.
  • a storage portion 31 for the liquid L may be formed by the bottom portion 32a and the trunk portion 32b.
  • the head 32 d forms the tip of the container body 32 .
  • the head portion 32d is thicker than other portions.
  • the neck portion 32c is positioned between the body portion 32b and the head portion 32d.
  • the neck portion 32c has a reduced width, especially a reduced diameter, with respect to the body portion 32b and the head portion 32d.
  • the container body 32 may be transparent so that the contained liquid L can be observed from the outside.
  • the container body 32 may have optical transparency.
  • being transparent and having light transmittance means that the transmittance of a specific wavelength is 10% or more, preferably 20% or more, and more preferably 50% or more.
  • the specific wavelengths are the wavelength of light that excites the fluorescent material 27 and the wavelength of fluorescence emitted by the fluorescent material 27 .
  • the specific wavelengths are wavelengths around 450 nm and wavelengths of 500 nm or more and 600 nm or less.
  • laser light or LED light having a wavelength that is attenuated according to the oxygen concentration in the optical path is transmitted through the container 30.
  • the specific wavelength is the wavelength that is attenuated according to the oxygen concentration is.
  • the wavelength attenuated according to the oxygen concentration is, for example, 760 nm. Note that the inspection method for the liquid-filled combination container 10L of the second embodiment, which will be described later, can also be used to measure the concentration of other gases such as carbon dioxide and water vapor in the container 30 .
  • the transparent member and part of the member and the light-transmitting member and part of the member referred to in this specification have a haze (JISK7136:2000) of 50% or less, preferably 30% or less, More preferably 10% or less, and even more preferably 5% or less.
  • the container 30 may further include fasteners 36, as shown in FIG.
  • the fixture 36 prevents the plug 34 from coming off the container body 32 .
  • the fixture 36 is attached to the head portion 32 d of the container body 32 .
  • the fixture 36 covers the periphery of the plate-like portion 34a of the plug 34, as shown in FIGS.
  • the fixture 36 presses the flange portion of the plate-like portion 34a against the head portion 32d.
  • the fixture 36 prevents the stopper 34 from coming off the container body 32 while partially exposing the stopper 34 .
  • the fixture 36 provides a liquid-tight and airtight seal between the stopper 34 and the container body 32 .
  • the fixture 36 keeps the container 30 airtight.
  • the fixture 36 may be a sheet of metal that can be secured to the head 32d.
  • the fixture 36 may be a cap that screws onto the head 32d.
  • the oxygen permeability coefficient of the material comprising container body 32 may be less than the oxygen permeability coefficient of the material comprising stopper 34 .
  • the container body 32 may have oxygen barrier properties. That is, the container 30 may be oxygen permeable only partially.
  • the oxygen permeability coefficient of the material constituting the portion having oxygen barrier properties may be 1 ⁇ 10 ⁇ 13 (cm 3 (STP) ⁇ cm/(cm 2 ⁇ sec ⁇ Pa)) or less, or 1 ⁇ 10 ⁇ 17 (cm 3 (STP) ⁇ cm/(cm 2 ⁇ sec ⁇ Pa)) or less.
  • the container 30 may contain at least one material of glass and cyclic olefin polymer.
  • container body 32 of container 30 may include at least one of glass and cyclic olefin polymer.
  • the cyclic olefin polymer contained in container 30 may be a cyclic olefin copolymer.
  • a glass bottle is exemplified as the container body 32 having the oxygen barrier property and containing glass.
  • a container body 32 made using a resin sheet or resin plate containing a cyclic olefin polymer is exemplified.
  • the resin sheet or resin plate may consist of a layer having a cyclic olefin polymer.
  • the container body 32 may include a laminate including a metal deposition film. Transparency can be imparted to the container body 32 using a laminate or glass as well as an oxygen barrier property. When the container 30 and the container main body 32 are transparent, the liquid L accommodated inside can be confirmed from the outside of the container 30 .
  • the container 30 may have a coating layer 38 forming the inner surface 30 a of the container 30 .
  • container body 32 of container 30 has base layer 37 and coating layer 38 .
  • the coating layer 38 constitutes the inner surface 30a of the container 30 and suppresses adhesion of the liquid L to the inner surface 30a of the container 30 .
  • the coating layer 38 forms at least the inner surface 30a of the container 30 at the fluorescent material installation position 39, which will be described later.
  • the coating layer 38 constitutes a portion of the inner surface 30a of the container 30 formed by the container body 32 and defining the headspace HS.
  • the coating layer 38 constitutes the entire portion of the inner surface 30 a of the container 30 defined by the container body 32 .
  • a part of the container has oxygen permeability means that in an atmosphere with a temperature of 23 ° and a humidity of 40% RH, oxygen permeates the part of the container at a predetermined oxygen permeation amount or more, and the inside of the container and the outside of the container. means that it is possible to move between
  • the predetermined oxygen permeation amount is 1 ⁇ 10 ⁇ 1 (mL/(day ⁇ atm)) or more.
  • the predetermined oxygen permeation amount may be 1 (mL/(day ⁇ atm)) or more, 1.2 (mL/(day ⁇ atm)) or more, or 3 (mL/(day ⁇ atm)) or more.
  • the amount of oxygen in the container 30 can also be adjusted by making a portion of the container 30 permeable to oxygen.
  • the predetermined oxygen permeation amount may be 100 (mL/(day ⁇ atm)) or less, 50 (mL/(day ⁇ atm)) or less, or 10 (mL/(day ⁇ atm)) or less.
  • an upper limit for the amount of oxygen permeation it is possible to suppress the leakage of water vapor and the like, and to suppress the influence of the high oxygen permeation rate on the liquid in the container 30 after the barrier container 40 is opened.
  • a range of oxygen transmission rates may be defined by combining any of the above lower limits of oxygen transmission rate with any of the above upper limits of oxygen transmission rate.
  • Test container 70 includes a compartment wall 71 .
  • the test container 70 has an internal space partitioned by partition walls 71 .
  • the partition wall portion 71 includes a portion of the container and a main wall portion 72 having oxygen barrier properties.
  • the permeation rate of a portion of the vessel is specified as the oxygen permeation rate of the test vessel 70 (mL/(day x atm)).
  • the oxygen concentration in the test container 70 is kept at, for example, 0.05% or less.
  • the test vessel 70 is connected to a first channel 76 and a second channel 77 .
  • the second flow path 77 is connected to an oxygen meter 79 that measures the amount of oxygen.
  • the oxygen meter 79 can measure the amount (mL) of oxygen flowing through the second flow path 77 .
  • As the oxygen measuring device 79 an oxygen quantity measuring device used in OXTRAN (2/61) manufactured by MOCON, USA can be used.
  • a first flow path 76 supplies gas into the test container 70 .
  • the first flow path 76 may supply gas that does not contain oxygen.
  • the first flow path 76 may supply an inert gas.
  • the first flow path 76 may supply nitrogen.
  • the second flow path 77 discharges the gas inside the test container 70 .
  • the first channel 76 and the second channel 77 maintain the test container 70 in a substantially oxygen-free state.
  • the oxygen concentration within test vessel 70 may be maintained at 0.05% or less, may be maintained at less than 0.03%, or may be maintained at 0%.
  • the test container 70 is placed in a test atmosphere with a temperature of 23° and a humidity of 40% RH.
  • the oxygen concentration of the atmosphere in which the test container 70 is placed is higher than the oxygen concentration inside the test container 70 .
  • the test atmosphere may be an air atmosphere.
  • the oxygen concentration in the air atmosphere is 20.95%.
  • test container 70 is positioned within test chamber 78 .
  • the atmosphere within test chamber 78 is maintained at a temperature of 23° and a humidity of 40% RH.
  • Air is supplied into the test chamber 78 from a supply path 78A.
  • the gas within the test chamber 78 is exhausted through the exhaust path 78B.
  • Supply line 78A and exhaust line 78B circulate air to maintain an oxygen concentration of 20.95% in test chamber 78.
  • a pump for circulating air may be provided in one of the supply channel 78A and the discharge channel 78B.
  • supply channel 78A and exhaust channel 78B may be open to an air atmosphere at atmospheric pressure.
  • the test container 70 need not be located within the test chamber 78 .
  • the test chamber 78 may be omitted and the test vessel 70 placed in an air atmosphere at atmospheric pressure.
  • FIG. 3 shows a method for measuring the amount of oxygen permeation, taking the oxygen-permeable portion 30X of the container 30 as an example.
  • the partition wall portion 71 is composed of the portion 30X of the container 30 having oxygen permeability and the main wall portion 72 having oxygen barrier properties.
  • the partition wall portion 71 may be configured by the portion 30X cut out from the container 30 and the main wall portion 72 connected to the peripheral portion of the portion 30X.
  • This main wall portion 72 has a through hole 72A that exposes the portion 30X.
  • a peripheral portion of the through hole 72A and a portion 30Y adjacent to the portion 30X may be airtightly joined.
  • the portion 30Y adjacent to the portion 30X is airtightly joined to the peripheral portion of the through hole 72A of the main wall portion 72 via the barrier joint material 73.
  • the plug 34 is a portion 30X having oxygen permeability.
  • Portions 32c and 32d forming the opening 33 of the container body 32 and the fixture 36 are airtightly connected to the main wall portion 72 via the barrier bonding material 73 as the portion 30Y adjacent to the oxygen permeable portion 30X. are doing.
  • the container body 32 is cut at the neck 32c.
  • the plug 34 is compressed and held within the opening 33 formed by the head 32 d of the container body 32 .
  • Fixing member 36 makes the space between container body 32 and stopper 34 airtight.
  • the container body 32 and fixture 36 having oxygen barrier properties are connected to the main wall portion 72 via a barrier joint material 73 .
  • Plug 34 is maintained in a condition similar to that it would be in closing container 30 in actual use, such as compression within opening 33 and clamping with fastener 36 . Therefore, the amount of oxygen permeation through the plug 34 can be measured under the same conditions as in actual use.
  • the method for measuring the amount of oxygen permeation (mL/(day ⁇ atm)) permeating through a portion of the container has been described above.
  • the oxygen permeation amount (mL/(day ⁇ atm)) permeating through the entire container can be determined by dividing the container into two or more parts and summing the oxygen permeation amounts measured for each part. For example, the oxygen permeation rate of container 30 shown in FIG. It can be identified by adding up the oxygen permeation amount and .
  • the oxygen permeation amount (mL/(day ⁇ atm)) of the container body 32 can be measured by using the test container 70 made by combining the container body 32 with the main wall portion 72 .
  • the volume of the container 30 may be, for example, 1 mL or more and 1100 mL or less, 3 mL or more and 700 mL or less, or 5 mL or more and 200 mL or less.
  • the container body 32 is a glass bottle. That is, the base material layer 37 of the container body 32 is made of glass. The base material layer 37 of the container body 32 is made of borosilicate glass, for example.
  • This container 30 may be a vial.
  • a vial is a container 30 that includes a container body 32 , a plug 34 inserted into an opening 33 of the container body 32 , and a seal as a fixture that fixes the plug 34 .
  • a hand gripper or the like is used to crimp the seal on the top of the container body together with the stopper.
  • the volume of the vial container 30 may be 1 mL or more, or 3 mL or more.
  • the volume of the vial container 30 may be 500 mL or less, or may be 200 mL or less.
  • the oxygen permeability coefficient of the material forming the stopper 34 may be greater than the oxygen permeability coefficient of the glass forming the container body 32 .
  • the container 30, which is a vial bottle can be stably placed on the mounting surface by bringing the bottom portion 32a of the container body 32 into contact with the mounting surface. That is, in the container 30, which is a vial bottle, the state in which the bottom portion 32a of the container body 32 is brought into contact with the mounting surface is the above-described state in which the container 30 is erected. At this time, the plug 34 is separated from the liquid L. The plug 34 does not come into contact with the liquid L. Therefore, oxygen permeation through the stopper 34 of the container 30 can be promoted in a normal storage state of the container 30 .
  • the illustrated container 30 can maintain a negative internal pressure under atmospheric pressure.
  • the container 30 can contain the gas under atmospheric pressure while maintaining the gas at a negative pressure.
  • the container 30 may be capable of containing gas under atmospheric pressure while maintaining the gas at a positive pressure. In these examples, container 30 may have sufficient rigidity to maintain its shape. However, the container 30 may deform somewhat under atmospheric pressure when maintaining the internal pressure at negative or positive pressure. Examples of the container 30 capable of maintaining the internal pressure at negative pressure or positive pressure include the specific examples illustrated above and cans made of metal.
  • Capable of containing gas under atmospheric pressure while maintaining a negative pressure means that the internal pressure can be kept at a negative pressure of 0.80 atm or more and the gas can be contained without damage.
  • the container 30 that can hold gas under atmospheric pressure while maintaining a negative pressure may be an airtight container even if the internal pressure is 0.80 atm.
  • the volume when the internal pressure is 0.80 atm can be maintained at 95% or more of the volume when the internal pressure is 1.0 atm.
  • the container 30 may have a container body 32 at least partially permeable to oxygen and a stopper 34 having oxygen barrier properties.
  • the barrier container 40 has a volume that can accommodate the container 30 .
  • the barrier container 40 can be closed by, for example, welding such as heat sealing or ultrasonic bonding, or bonding using a bonding material such as an adhesive or an adhesive.
  • the barrier container 40 may be an airtight container.
  • the volume of the barrier container 40 may be, for example, 5 mL or more and 1200 mL or less.
  • the container 30 is a small container such as a vial bottle, for example, a container with a volume of 1 mL or more and 20 mL or less
  • the volume of the barrier container 40 may be 1.5 mL or more and 500 mL or less.
  • the barrier container 40 has oxygen barrier properties. That the container has oxygen barrier properties means that the oxygen permeability (mL/(m 2 ⁇ day ⁇ atm)) of the container is 1 or less.
  • the oxygen permeability (mL/(m 2 ⁇ day ⁇ atm)) of the container having oxygen barrier properties may be 0.5 or less, or 0.1 or less.
  • Oxygen permeability is measured according to JIS K7126-1. Oxygen permeability is measured using OXTRAN, 2/61, which is a permeability meter manufactured by MOCON, USA, under an environment of temperature 23° C. and humidity 40% RH. For containers to which JIS K7126-1 is not applied, the oxygen permeability may be specified by measuring the oxygen permeability described above and dividing the obtained oxygen permeability by the surface area.
  • the oxygen permeability coefficient of the material constituting the barrier container 40 having oxygen barrier properties may be 1 ⁇ 10 ⁇ 13 (cm 3 (STP) ⁇ cm/(cm 2 ⁇ sec ⁇ Pa)) or less, and may be 1 ⁇ 10 ⁇ It may be 17 (cm 3 (STP) ⁇ cm/(cm 2 ⁇ sec ⁇ Pa)) or less.
  • the oxygen barrier container 40 examples include a container having a metal layer formed by vapor deposition or transfer, and a glass bottle.
  • the barrier container 40 may include a laminate including a layer having oxygen barrier properties.
  • the laminate may include a resin layer or a metal deposition film.
  • the resin layer or metal deposited film may have oxygen barrier properties.
  • Barrier container 40 includes a transparent portion. In other words, the barrier container 40 has a light transmission position 40b having light transmission properties. A portion of the barrier container 40 may be transparent.
  • the entire barrier container 40 may be transparent.
  • the barrier container 40 using a laminate and the barrier container 40 using glass or resin can be imparted with oxygen barrier properties and transparency. By imparting transparency to the barrier container 40 , the liquid-filled container 30 ⁇ /b>L accommodated therein can be confirmed from the outside of the barrier container 40 .
  • the barrier container 40 may contain at least one of acrylic resin and polyethylene terephthalate resin.
  • the resin layer may include either one or both of an acrylic resin and a polyethylene terephthalate resin.
  • the barrier container 40 is made of a resin film having oxygen barrier properties.
  • the barrier container 40 is a so-called pouch.
  • the barrier container 40 shown in FIG. 1 is a so-called gusset bag.
  • the barrier container 40 includes a first main film 41a, a second main film 41b, a first gusset film 41c and a second gusset film 41d.
  • the films 41a to 41d are airtightly joined by, for example, welding such as heat sealing or ultrasonic joining, or joining using a joining material such as an adhesive or an adhesive.
  • one folded film may constitute two or more of the films 41a to 41d that are adjacently arranged.
  • the gusset bag can form a rectangular bottom surface on the barrier container 40 .
  • the barrier container 40 may include a bottom film 41e together with the first main film 41a and the second main film 41b instead of the gusset bag.
  • This pouch is also called a standing pouch. This pouch can also form the bottom surface, and the container 30 can be stably stored in the barrier container 40 .
  • a barrier container 40 that can be developed in a plane may be used. Any of the barrier containers 40 shown in FIGS. 5 to 7 can be produced by bonding resin films at the sealing portion 43.
  • FIG. The barrier container 40 shown in FIG. 5 can be produced by joining the first main film 41a and the second main film 41b at the sealing portion 43 provided on the circumference thereof.
  • the barrier container 40 shown in FIG. 6 has the film 41 folded at the folding portion 41x.
  • the barrier container 40 can be produced by joining the facing portions of the folded film 41 at the sealing portion 43 .
  • a storage space is formed in a portion surrounded by the folded portion 41x and the three-sided seal portion 43. As shown in FIG.
  • the barrier container 40 shown in FIG. 7 is also called a pillow type.
  • the barrier container 40 is obtained by forming the film 41 into a tubular shape by bonding both ends of the film 41 to each other as the sealing portions 43 , and further bonding both ends of the cylindrical shape as the sealing portions 43 .
  • the barrier container 40 shown in FIGS. etc. may be supported.
  • the barrier container 40 shown in FIGS. 5-7 may be supported by a stand member or the like so that the container 30 is upright.
  • the barrier container 40 is supported so that the opening 33 side of the container body 32 faces upward.
  • the film forming the barrier container 40 may be transparent.
  • the barrier container 40 contacts the outer surface 30b of the container 30 at the fluorescent material installation position 39, which will be described later.
  • the barrier container 40 contacts the outer surface 30b of the fluorescent material installation position 39 when the fluorescent material 27 is irradiated with light and the fluorescent time or fluorescent intensity of the fluorescent material 27 is measured by an inspection method to be described later.
  • the barrier container 40 is in contact with the outer surface 30b of the fluorescent material installation position 39 at the light transmission position 40b.
  • the barrier container 40 need not come into contact with the outer surface 30b of the fluorescent material installation position 39 when the fluorescent material 27 is irradiated with light and the fluorescence time or fluorescence intensity of the fluorescent material 27 is measured by an inspection method to be described later. .
  • FIG. 8 is a cross-sectional view showing a state in which the barrier container 40 in the liquid-filled combination container 10L shown in FIG.
  • the illustration of the layer structure of the container body 32 is omitted, and only the outline of the cross section of the container body 32 is shown.
  • FIG. 8 for convenience of illustration, the positions at which the oxygen scavenger 21 and the oxygen detector 25, which will be described later, are fixed to the inner surface of the barrier container 40 are changed from the positions shown in FIG.
  • barrier container 40 The specific configuration of the barrier container 40 described above is merely an example, and various modifications are possible.
  • the liquid-filled combination container 10L further comprises at least one oxygen reactant 20 capable of reacting with oxygen in the barrier container 40.
  • the oxygen reactive agent 20 is an oxygen scavenger 21 that absorbs oxygen in the barrier container 40 or an oxygen detector 25 that detects the oxygen state in the barrier container 40 .
  • a liquid-filled combination container 10L may include a plurality of oxygen reactants 20 .
  • the liquid-filled combination container 10L includes two oxygen reactants 20.
  • the liquid-filled combination container 10L includes an oxygen scavenger 21 as the first oxygen reactant 20 .
  • the liquid-filled combination container 10L has an oxygen detector 25 as the second oxygen reactant 20 .
  • the oxygen reactant 20 is fixed to at least one of the outer surface 30 b of the container 30 and the inner surface of the barrier container 40 .
  • two oxygen reactants 20 are secured to the inner surface of barrier container 40 .
  • the oxygen-reactive agent 20 is fixed at a position that does not interfere with the irradiation of the fluorescent material 27 with the light that causes the fluorescent material 27 to fluoresce when the oxygen concentration in the container 30 is examined in the method for inspecting the liquid-filled combination container 10L, which will be described later. be.
  • the oxygen-reactive agent 20 is fixed to the outer surface 30 b of the container 30
  • the oxygen-reactive agent 20 is fixed to the outer surface 30 b of the container 30 at a position that does not overlap the fluorescent material installation position 39 .
  • the oxygen-reactive agent 20 when the oxygen-reactive agent 20 is fixed to the inner surface of the barrier container 40 , the oxygen-reactive agent 20 is positioned on the inner surface of the barrier container 40 at the fluorescent material installation position 39 in the direction perpendicular to the inner surface of the barrier container 40 . Fixed in a non-overlapping position. As an example, the oxygen reactive agent 20 is fixed so as not to be positioned between the light transmitting position 40b of the barrier container 40 and the fluorescent material installation position 39 of the container 30 . This prevents the oxygen reactant 20 from blocking the light transmitted through the light transmission position 40 b of the barrier container 40 and the fluorescent material installation position 39 of the container 30 . Therefore, the fluorescent material 27 can be irradiated with light from the outside of the barrier container 40 by passing through the light transmission position 40 b of the barrier container 40 and the fluorescent material installation position 39 of the container 30 .
  • the method of fixing the oxygen reactant 20 to at least one of the outer surface 30b of the container 30 and the inner surface of the barrier container 40 is not particularly limited.
  • the oxygen-reactive agent 20 may be fixed to at least one of the outer surface 30b of the container 30 and the inner surface of the barrier container 40 by bonding with an adhesive or the like.
  • the oxygen reactive agent 20 may be fixed to the outer surface 30 b of the container 30 and the inner surface of the barrier container 40 by being sandwiched between the outer surface 30 b of the container 30 and the inner surface of the barrier container 40 .
  • the oxygen reactant 20 may be fixed to at least one of the outer surface 30 b of the container 30 and the inner surface of the barrier container 40 by a member (not shown) arranged inside and outside the container 40 with barrier properties.
  • the oxygen scavenger 21 and the oxygen detector 25 shown in FIG. 1 are adhered to the inner surface of the barrier container 40 with an adhesive (not shown).
  • the oxygen reactant 20 may be fixed to the outer surface 30b of the container 30 so that its position relative to the outer surface 30b of the container 30 does not change even when the orientation of the liquid-filled combination container 10L is changed.
  • the oxygen-reactive agent 20 can be fixed to the outer surface 30b of the container 30 by using an adhesive, for example, so that its position relative to the outer surface 30b of the container 30 does not change even when the orientation of the liquid-filled combination container 10L is changed.
  • the oxygen reactant 20 may be fixed to the inner surface of the barrier container 40 so that its position relative to the inner surface of the barrier container 40 does not change even when the orientation of the liquid-filled combination container 10L is changed.
  • the oxygen-reactive agent 20 can be fixed to the inner surface of the barrier container 40 by using an adhesive, for example, so that its position relative to the inner surface of the barrier container 40 does not change even when the orientation of the liquid-filled combination container 10L is changed.
  • the oxygen reactant 20 is applied to the outer surface 30b of the container 30 and the barrier container 40 by utilizing the action of gravity. It may be fixed to at least one of the inner surfaces.
  • the oxygen reactant 20 is sandwiched between the outer surface 30b of the container 30 and the inner surface of the barrier container 40, the horizontal movement is suppressed, and the vertical movement is suppressed by the action of gravity. may In this case, it is assumed that the oxygen reactant 20 is fixed to the outer surface 30b of the container 30 and the inner surface of the barrier container 40.
  • the oxygen reactant 20 is sandwiched between a member (not shown) disposed inside the barrier container 40 and outside the container 30 and the outer surface 30b of the container 30, thereby suppressing horizontal movement, and Vertical movement may be suppressed by the action of gravity.
  • the oxygen reactant 20 is fixed to the outer surface 30b of the container 30.
  • the oxygen reactant 20 is sandwiched between a member (not shown) arranged inside the barrier container 40 and outside the container 30 and the inner surface of the barrier container 40, thereby suppressing horizontal movement.
  • vertical movement may be suppressed by the action of gravity. In this case, it is assumed that the oxygen reactant 20 is fixed to the inner surface of the barrier container 40 .
  • the position of the oxygen reactant 20 in the liquid-filled combination container 10L is also stably determined in the above-described fixing mode utilizing the action of gravity. Even in the above-described fixed mode utilizing the action of gravity, the movement of the oxygen reactant 20 due to shaking of the liquid-filled combination container 10L is suppressed.
  • the oxygen scavenger 21 is not particularly limited as long as it contains a composition capable of absorbing oxygen.
  • an iron-based oxygen scavenger or a non-ferrous oxygen scavenger can be used.
  • the oxygen absorber 21 includes, for example, metal powder such as iron powder, reducing inorganic substances such as iron compounds, polyhydric phenols, polyhydric alcohols, reducing organic substances such as ascorbic acid or salts thereof, or metal complexes. It contains an oxygen scavenger composition that is the main ingredient in the oxygen absorption reaction.
  • the oxygen scavenger 21 contains, for example, iron oxide.
  • the oxygen absorber 21 is, for example, an oxygen absorber available from Mitsubishi Gas Chemical Co., Ltd. under the trade name of "AGELESS".
  • the composition described above is contained in the oxygen scavenger 21, for example, as the oxygen scavenger main body 22 shown in FIG.
  • the liquid-filled combination container 10L includes the oxygen scavenger 21 housed in the barrier container 40 together with the liquid-filled container 30L.
  • the oxygen scavenger 21 may include a main body 22 of the oxygen scavenger.
  • the oxygen absorber 21 includes an oxygen-permeable package 22a and an oxygen absorber main body 22 housed in the package 22a.
  • the oxygen absorber 21 containing the oxygen absorber main body 22 the iron-based moisture-dependent type FX type, the iron-based self-reacting type S type, the SPE type, the ZP type, and the ZI- type available from Mitsubishi Gas Chemical Co., Inc.
  • PT type ZJ-PK type, E type, organic self-reacting GLS type, GL-M type, GE type, etc.
  • oxygen absorber 21 containing the oxygen absorber main body 22 ZH type, Z-PK Ya, Z-PR, Z-PKR, ZM type, etc. for pharmaceuticals available from Mitsubishi Gas Chemical Co., Ltd. may be used. .
  • FIG. 10 shows an example of a laminate 46 including the deoxidizing film 23.
  • the laminate 46 including the deoxidizing film 23 may constitute at least part of the barrier container 40 .
  • the laminate 46 including the oxygen scavenging film 23 may constitute the films 41a-41e of the barrier container 40 shown in FIGS. 1 and 4-7.
  • the laminate 46 shown in FIG. 10 includes a first layer 46a, a second layer 46b and a third layer 46c.
  • the first layer 46a may be the outermost layer made of polyethylene terephthalate, nylon, or the like.
  • the second layer 46b may be an oxygen barrier layer made of aluminum foil, inorganic deposition film, metal deposition film, or the like.
  • the third layer 46c may be the innermost layer forming a heat seal layer.
  • the illustrated third layer 46c includes a base material made of a thermoplastic resin and the oxygen scavenger 21 dispersed in the base material.
  • the barrier container 40 may include the deoxidizing film 23 containing the deoxidizing agent 21 as part of the laminate 46 .
  • the oxygen absorber 21 is not limited to the heat seal layer and the innermost layer 46c, and may be contained in the adhesive layer or the intermediate layer of the laminate.
  • container 30 may include oxygen scavenging film 23 containing oxygen scavenger 21 .
  • the oxygen scavenger 21 may be provided separately from the container 30 or the barrier container 40 as in the examples shown in FIGS.
  • the deoxidizing agent 21 is the barrier container 40 .
  • the oxygen scavenger 21 is considered to be secured to the outer surface 30 b of the container 30 .
  • the deoxidizing film 23 that does not constitute at least part of the barrier container 40 may be fixed to at least one of the outer surface 30 b of the container 30 and the inner surface of the barrier container 40 . If the oxygen scavenger film 23 that does not form at least a portion of the barrier container 40 is fixed to the outer surface 30b of the container 30, it is considered that the oxygen scavenger 21 is fixed to the outer surface 30b of the container 30. When the deoxidizing film 23 that does not form at least a part of the barrier container 40 is fixed to the inner surface of the barrier container 40 , it is considered that the oxygen scavenger 21 is fixed to the inner surface of the barrier container 40 .
  • the oxygen concentration in the barrier container 40 decreases, and the oxygen in the container 30 moves to the barrier container 40 .
  • the oxygen concentration in the barrier container 40 and the oxygen concentration in the container 30 can be reduced more effectively.
  • the oxygen concentration in the barrier container 40 and the oxygen concentration in the container 30 can be kept low, for example, less than 0.3%, It can be maintained at 0.1% or less, 0.05% or less, less than 0.03%, or even 0%.
  • the oxygen concentration in the container 30 decreases, the amount of dissolved oxygen in the liquid L contained in the container 30 also decreases.
  • the amount of dissolved oxygen in the liquid L can be significantly reduced, for example, less than 0.15 mg/L, less than 0.04 mg/L, 0 0.03 mg/L or less, 0.02 mg/L or less, less than 0.015 mg/L, and more preferably 0 mg/L.
  • the amount of oxygen scavenger 21 is set to an amount that can absorb the total amount of oxygen present in container 30 and barrier container 40 .
  • the oxygen concentration (%) in the container 30 is determined by a method similar to the method for determining the oxygen concentration in the container 30 in the inspection method for the liquid-filled combination container 10L in the first embodiment or the second embodiment, which will be described later. can be sought.
  • the oxygen concentration (%) in the barrier container 40 can be obtained by a method similar to the method for obtaining the oxygen concentration in the barrier container 40 in the inspection method for the liquid-filled combination container 10L in the third embodiment, which will be described later. .
  • the saturation solubility of oxygen in the liquid L can be specified from the determined oxygen concentration (%) and temperature in the headspace HS. Based on the specified saturated solubility, the oxygen dissolution amount (mg/L) of the liquid L can be specified.
  • the oxygen detector 25 may display the detected oxygen state.
  • the oxygen detector 25 may detect oxygen concentration.
  • the oxygen detector 25 may display the detected oxygen concentration value.
  • the oxygen detection material 25 may display the detected oxygen concentration value in color.
  • the oxygen sensing material 25 may contain a variable organic dye that reversibly changes color due to oxidation and reduction.
  • the oxygen reducing agent includes an organic dye such as a thiazine dye, an azine dye, or an oxazine dye, and a reducing agent, and may be solid.
  • the oxygen reducing agent may also include an oxygen indicator ink composition.
  • the oxygen indicator ink composition may contain a resin solution, a thiazine dye or the like, a reducing sugar, and an alkaline substance. Reducing sugars, such as thiazine dyes, and alkaline substances may be dissolved or dispersed in the resin solution. Substances contained in the oxygen sensing material 25 may reversibly change due to oxidation and reduction.
  • the oxygen detecting material 25 accommodated in the container before the deoxidation is completed changes its display color as the container is deoxygenated.
  • the amount of oxygen in the container can be observed from outside the transparent container to determine the oxygen-related conditions within the container.
  • the oxygen detecting material 25 housed in the container indicates an increase in oxygen concentration after deoxidation is completed, for example, a state in which oxygen has flowed into the container due to the formation of a pinhole in the container during the distribution process or the like. It can be notified by changing the color.
  • oxygen sensing material 25 includes a tablet.
  • the oxygen detecting material 25 becomes pink when the surrounding oxygen concentration is sufficiently low, and becomes blue when the surrounding oxygen concentration is high.
  • the oxygen detecting material 25 available from Mitsubishi Gas Chemical Co., Ltd. under the trade name of "AGELESS EYE” may be used.
  • an oxygen detecting material coated with an ink composition having an oxygen detecting function for example, an oxygen detecting material 25 available from Mitsubishi Gas Chemical Co., Ltd. under the trade name of "Paper Eye” may be used.
  • "Ageless Eye” and “Paper Eye” are functional products that can easily indicate an oxygen-free state with an oxygen concentration of less than 0.1% by volume in a transparent container by color change.
  • the oxygen detecting material 25 a material that can be used for preserving the freshness of foods, preserving the quality of medical drugs, etc., together with an oxygen scavenger may be used.
  • a material that can be used to maintain the freshness of foods and the quality of medical and pharmaceutical products is used. good too.
  • the oxygen detecting material 25 may have a display portion 26 observable from the outside of the transparent barrier container 40 .
  • the oxygen detecting material 25, like the oxygen scavenger 21, is housed in a barrier container 40.
  • the oxygen detecting material 25 may be bonded to the inner surface of the barrier container 40 or the outer surface of the container 30 via welding or a bonding material.
  • the oxygen detecting material 25 may be arranged so that the display portion 26 thereof is not observable by the oxygen scavenger 21 .
  • the oxygen absorber 21 and the oxygen detector 25 are preferably arranged so as not to cover the label.
  • the oxygen detection material 25 may detect the oxygen state within the container 30 .
  • This oxygen sensing material 25 may be accommodated in the container 30 .
  • the oxygen sensing material 25 may indicate the sensed oxygen state within the container 30 .
  • the oxygen detection material 25 may detect the oxygen concentration inside the container 30 .
  • the oxygen detector 25 may display the detected oxygen concentration value in the container 30 .
  • the oxygen detecting material 25 may display the detected oxygen concentration value in the container 30 by color.
  • the fluorescent material 27 is provided on the inner surface 30 a of the fluorescent material installation position 39 of the container 30 .
  • the fluorescent material installation position 39 is separated from the contact area 31a.
  • the fluorescent material placement position 39 where the fluorescent material 27 is provided on the inner surface 30 a is the position where the headspace HS of the container 30 is in contact.
  • the fluorescent material installation position 39 is located in the container body 32 . That is, the fluorescent material 27 is provided on the portion of the inner surface 30 a of the container 30 that is formed by the container body 32 .
  • the fluorescent material placement location 39 may be located on the spigot 34 . That is, the fluorescent material 27 is provided on the portion of the inner surface 30a of the container 30 formed by the plug 34 .
  • the container 30 has optical transparency at least at the fluorescent material installation position 39 .
  • the fluorescent material 27 is a material whose fluorescent time or fluorescent intensity varies depending on the surrounding oxygen concentration.
  • the excitation wavelength of the fluorescent material 27 is, for example, 498 nm or more and 600 nm or less.
  • Fluorescent materials include, for example, Funakoshi Co., Ltd.
  • the liquid-filled container 30L further includes an adhesive layer 28 that adheres the fluorescent material 27 to the inner surface 30a of the fluorescent material installation position 39 of the container 30.
  • the adhesive layer 28 has optical transparency.
  • the adhesive layer 28 contains a resin that does not fluoresce.
  • the adhesive layer 28 contains at least one resin selected from the group consisting of non-fluorescent acrylic resins, silicone resins, and epoxy resins.
  • the adhesive layer 28 may contain at least one resin selected from the group consisting of non-fluorescent photocurable acrylic resins, photocurable silicone resins, and epoxy resins.
  • the term "light-curing acrylic resin that does not fluoresce” means a light-curing acrylic resin that has not been processed to fluoresce when irradiated with light, such as containing a fluorescent agent.
  • "Non-fluorescent light-curing acrylic resin” is not processed to fluoresce when exposed to light, but it is a light-curing type that emits the fluorescence of the material itself when exposed to light, that is, autofluorescence. Contains acrylic resin. Whether or not the acrylic resin light is a curable acrylic resin and whether or not the silicone resin is a photocurable silicone resin can be determined by analyzing the composition of the resin, particularly by analyzing the monomers contained in the resin.
  • the fluorescent material 27 may be adhered to the inner surface 30a of the fluorescent material installation position 39 of the container 30 by the following method. First, between the inner surface 30 a of the fluorescent material installation position 39 of the container 30 and the fluorescent material 27 , a photocurable acrylic resin that does not fluoresce is placed. Next, the adhesive layer 28 is formed by curing the photocurable acrylic resin by irradiation with light. Further, by arranging a photocurable silicone resin between the inner surface 30a of the fluorescent material installation position 39 of the container 30 and the fluorescent material 27 and curing it by irradiation with light, the fluorescent material 27 may be adhered. good. Alternatively, the fluorescent material 27 may be adhered by arranging an epoxy resin between the inner surface 30a of the fluorescent material installation position 39 of the container 30 and the fluorescent material 27 and curing the resin.
  • the inspection method for inspecting the oxygen concentration in the container 30 of the liquid-filled combination container 10L includes a fluorescence measurement process and a measurement process. Moreover, the inspection method for inspecting the oxygen concentration in the container 30 of the liquid-filled container 30L includes a fluorescence measurement process and a measurement process.
  • the inspection method for inspecting the oxygen concentration in the container 30 of the liquid-filled combination container 10 ⁇ /b>L further includes the step of bringing the barrier container 40 into contact with the outer surface 30 b of the fluorescent material installation position 39 of the container 30 .
  • a step of bringing the barrier container 40 into contact with the outer surface 30b of the fluorescent material installation position 39 of the container 30 is performed.
  • the barrier container 40 is brought into contact with the outer surface 30b of the fluorescent material installation position 39 of the container 30 by pressing with the .
  • the barrier container 40 is brought into contact with the outer surface 30b of the fluorescent material placement location 39 of the container 30 at the light transmission location 40b.
  • the barrier container 40 has flexibility as described above. Therefore, by pushing the barrier container 40 with the detector 80 , the barrier container 40 is brought into contact with the outer surface 30 b of the fluorescent material installation position 39 of the container 30 .
  • the detection device 80 is a device that measures the fluorescence time or fluorescence intensity of a fluorescent material.
  • the detection device 80 has a rod-like shape.
  • the detection device 80 has an illumination section 81 and a sensor section 82 .
  • the illumination section 81 and the sensor section 82 are provided at one end 80a of the detection device 80 having a rod-like shape.
  • the illumination section 81 is a section that emits light that causes the fluorescent material 27 to fluoresce.
  • the illumination used as the illumination unit 81 is not particularly limited as long as it emits light having a wavelength that causes the fluorescent material 27 to fluoresce.
  • an LED light is used as the illumination unit 81 .
  • the fluorescent material 27 is FITC manufactured by Funakoshi Co., Ltd.
  • a light source that emits light with a wavelength of approximately 500 nm is used as the illumination section 81 .
  • an illumination unit that emits light with a wavelength of approximately 520 nm is used as the illumination unit 81 .
  • the fluorescent material 27 is Alexa Fluor 555 manufactured by Funakoshi Co., Ltd.
  • an illumination unit that emits light with a wavelength of approximately 550 nm is used as the illumination unit 81 .
  • the illumination unit 81 may be an LED light that emits green light with a wavelength of 525 nm.
  • the sensor section 82 is a section that measures the fluorescence time or fluorescence intensity of the fluorescent material 27 .
  • the sensor unit 82 is not particularly limited as long as it is a sensor capable of measuring the fluorescence time or fluorescence intensity of the fluorescent material 27 .
  • a sensor used as the sensor unit 82 is, for example, a detector attached to XY-1 SMA trace manufactured by PreSens.
  • the detection part of the sensor is, for example, a CCD array.
  • one end 80 a of the detection device 80 provided with the illumination section 81 and the sensor section 82 is brought into contact with the barrier container 40 and the barrier container 40 is pushed by the detection device 80 .
  • the barrier container 40 is in contact with the outer surface 30 b of the fluorescent material installation position 39 of the container 30 .
  • the fluorescence measurement process is performed.
  • the fluorescent material 27 is irradiated with light that causes the fluorescent material 27 to fluoresce, and the fluorescence time or fluorescence intensity of the fluorescent material 27 is measured.
  • the illumination unit 81 is used to irradiate the fluorescent material 27 with light that causes the fluorescent material 27 to fluoresce.
  • the fluorescence time or fluorescence intensity of the fluorescent material 27 is measured using the sensor section 82 .
  • the fluorescence measurement process In the fluorescence measurement process, light that causes the fluorescent material 27 to fluoresce is transmitted through the light transmission position 40b of the barrier container 40 and the fluorescent material installation position 39 of the container 30, and the fluorescent material 27 is irradiated with the light.
  • the fluorescence measurement step is performed while the barrier container 40 is in contact with the outer surface 30 b of the fluorescent material installation position 39 of the container 30 .
  • light that causes the fluorescent material 27 to fluoresce is transmitted through the fluorescent material installation position 39 of the container 30 of the barrier container 40 to irradiate the fluorescent material 27 .
  • the barrier container 40 is pushed by the detection device 80 to contact the outer surface 30 b of the fluorescent material installation position 39 of the container 30 .
  • the fluorescent material 27 is irradiated with light using the illumination unit 81 while the detection device 80 is in contact with the portion of the barrier container 40 that contacts the fluorescent material installation position 39 . .
  • the light from the illumination unit 81 is transmitted through the fluorescent material installation position 39 of the container 30 and the portion of the barrier container 40 contacting the fluorescent material installation position 39 to irradiate the fluorescent material 27 .
  • Light generated by the fluorescence of the fluorescent material 27 passes through the fluorescent material installation position 39 of the container 30 and the portion of the barrier container 40 contacting the fluorescent material installation position 39 and reaches the sensor section 82 . Therefore, the fluorescence time or fluorescence intensity of the fluorescent material 27 can be measured using the sensor section 82 .
  • the illumination unit 81 is an LED light that emits green light with a wavelength of 525 nm
  • the fluorescent material 27 emits light with a wavelength longer than 525 nm, such as red light.
  • the oxygen concentration in the container 30 is inspected based on the fluorescence time or fluorescence intensity of the fluorescent material 27 measured in the fluorescence measurement process.
  • the fluorescent material 27 differs in fluorescence time or fluorescence intensity depending on the ambient oxygen concentration.
  • the oxygen concentration (%) in the container 30 is measured based on the correspondence relationship between the ambient oxygen concentration and the fluorescence time or fluorescence intensity in the fluorescent material 27 .
  • the oxygen concentration (%) in the container 30 measured in the measurement step is the oxygen concentration (%) in the gas accommodated in the headspace HS of the container 30 .
  • the barrier container 40 is The step of contacting the outer surface 30b of the material placement position 39 is not performed. Even in this case, in the fluorescence measurement process, the oxygen concentration in the container 30 can be inspected by irradiating the fluorescent material 27 with light that causes the fluorescent material 27 to fluoresce through the fluorescent material installation position 39 of the container 30 .
  • the state of the liquid-filled container 30L or the liquid-filled combination container 10L can be inspected by inspecting the oxygen concentration (%) in the container 30 measured in the measurement process. For example, from the measured oxygen concentration (%) in the container 30, it can be inspected whether the oxygen concentration in the container 30 has been sufficiently reduced by the oxygen absorber 21 or the like. For example, if the oxygen concentration (%) in the container 30 measured in the measurement step is less than 0.3%, it can be determined that the oxygen concentration in the container 30 has been sufficiently reduced. Further, when the measured oxygen concentration (%) in the container 30 is 0.1% or less, 0.05% or less, or less than 0.03%, the oxygen concentration in the container 30 is sufficiently reduced. It can be judged that
  • the oxygen dissolution amount (mg/L) in the liquid L of the liquid container 30L is sufficiently determined by the oxygen absorber 21 or the like. may be checked to see if it has been reduced to For example, it is possible to inspect whether the oxygen dissolution amount (mg/L) in the liquid L is sufficiently reduced based on the change in the oxygen concentration (%) in the container 30 over time. If a sufficient amount of time has elapsed since the liquid-filled combination container 10L was manufactured, the oxygen movement between the headspace HS of the container 30 and the liquid L will reach equilibrium.
  • the oxygen concentration (%) in the container 30 is sufficiently reduced in such an equilibrium state, it can be determined that the dissolved oxygen amount (mg/L) in the liquid L is sufficiently reduced.
  • the change in the oxygen concentration (%) in the container 30 over time is determined by measuring the oxygen concentration (%) in the container 30 by the method described above at a plurality of different time points after the liquid-filled combination container 10L is manufactured. obtained by In this case, the oxygen concentration (%) in the container 30 is measured, for example, every day.
  • a specific method for inspecting whether the oxygen dissolution amount (mg/L) in the liquid L has been sufficiently reduced based on the time-dependent change in the oxygen concentration (%) in the container 30 will be described.
  • the point in time when the oxygen concentration (%) in the container 30 becomes less than the reference value is specified.
  • the change in the oxygen concentration (%) in the container 30 over time was observed. It can be judged that the oxygen dissolution amount (mg/L) in L is sufficiently reduced.
  • the reference value of the oxygen concentration (%) in the container 30 in this case is, for example, 0.3%.
  • the reference value of the oxygen concentration (%) inside the container 30 may be 0.1%, 0.05%, or 0.03%.
  • the rate of decrease in the oxygen concentration (%) in the container 30 may be calculated to check whether the reduction rate is sufficiently high.
  • the unit of "decrease rate” is (%/day).
  • the rate of decrease (%/day) can be adjusted by the amount of oxygen scavenger 21, the volume of container 30, the volume of barrier container 40, the amount of liquid L, the oxygen permeability of container 30, and the like.
  • the reference value of the rate of decrease until the oxygen concentration (%) in the container 30 is determined to be sufficiently high and the oxygen concentration in the container 30 is 0.1% or less may be 20%/day or more. , 25%/day or more, 30%/day or more, 35%/day or more, or 40%/day or more.
  • the oxygen partial pressure in the container 30 is measured together with the oxygen concentration in the container 30, and the state of the liquid-filled container 30L or the liquid-filled combination container 10L is inspected based on the oxygen partial pressure in the container 30. good too.
  • a method of manufacturing the liquid-filled combination container 10L will be explained. 30 L of liquid containing containers with adjusted oxygen concentration are obtained by manufacturing 10 L of liquid containing combination containers.
  • the method for manufacturing the liquid-filled combination container 10L may include an inspection step of inspecting the liquid-filled combination container 10L by the inspection method described above.
  • the liquid-filled container 30L and the barrier container 40 before closing are prepared.
  • the liquid-filled container 30L is manufactured by filling the liquid L into the container 30 .
  • a liquid L such as food or medicine is manufactured using a manufacturing line installed in an aseptic environment maintained at positive pressure.
  • the aseptic environment is maintained at a positive pressure from the viewpoint of suppressing the invasion of foreign substances such as bacteria.
  • the internal pressure of the obtained liquid-filled container 30L becomes a positive pressure, similar to the manufacturing environment.
  • the partial volume of the container 30 (the volume of the headspace HS) obtained by subtracting the volume of the liquid L from the volume of the container 30 may be 50 mL or less, 30 mL, 10 mL, or 5 mL or less.
  • the volume of the liquid L contained in the container 30 may be 20 mL or less, or may be 10 mL or less.
  • Part of the barrier container 40 obtained by subtracting the volume occupied by the container 30 from the volume of the barrier container 40 in the partial volume of the container 30 (the volume of the headspace HS) (mL) obtained by subtracting the volume of the liquid L from the volume of the container 30
  • An upper limit and a lower limit may be set for the ratio (%) to the volume (mL). This percentage may be 50% or less, or 20% or less.
  • the oxygen concentration in the container 30 can be sufficiently and quickly reduced.
  • a storage space for the container 30 can be secured within the barrier container 40 , and the container 30 can be easily stored within the barrier container 40 .
  • the time from closing of the barrier container 40 containing the container 30 to equilibrium of oxygen permeation through the container 30 can be shortened.
  • This ratio may be 5% or more, or 10% or more.
  • the obtained liquid-filled container 30L is housed in the barrier container 40.
  • the barrier container 40 before closing still has an opening 40a for accommodating the liquid container 30L.
  • the upper edges of the films 41a-41d are not joined together to form the opening 40a.
  • the liquid container 30L is accommodated in the barrier container 40 through the opening 40a.
  • At least one oxygen reactive agent 20 capable of reacting with oxygen in the barrier container 40 is provided.
  • an oxygen scavenger 21 that absorbs oxygen in the barrier container 40 is provided.
  • the oxygen scavenger 21 shown in FIGS. 1 and 8 the oxygen scavenger 21 is accommodated in the barrier container 40 .
  • Arrangement of the oxygen reactive agent 20 such as the oxygen scavenger 21 in the barrier container 40 and arrangement of the liquid-filled container 30L in the barrier container 40 may be performed first, or they may be performed in parallel. You may
  • the amount of oxygen scavenger 21 is set to an amount that can absorb the total amount of oxygen present in container 30 and barrier container 40 .
  • the inside of the barrier container 40 may be replaced with an inert gas before the step of closing the barrier container 40, which will be described later.
  • an inert gas By replacing with an inert gas, the oxygen concentration (%) in the barrier container 40 can be sufficiently reduced below atmospheric pressure. This causes oxygen to move from the container 30 to the barrier container 40, and the amount of oxygen in the container 30 can be quickly reduced. By quickly reducing the amount of oxygen in the container 30, decomposition of the liquid L by oxygen can be suppressed more effectively.
  • An inert gas is a stable gas with low reactivity. Examples of inert gases include rare gases such as nitrogen, helium, neon, and argon.
  • Substitution with an inert gas can be achieved, for example, by blowing an inert gas into the barrier container 40 or closing the barrier container 40 in a chamber whose atmosphere has been replaced with an inert gas. . According to these, the oxygen concentration in the barrier container 40 can be reduced to 0.5% or more and 1.0% or less. Since the barrier container 40 does not directly contain a liquid, the replacement with the inert gas inside the barrier container 40 can be carried out smoothly.
  • the barrier container 40 containing the liquid container 30L is closed.
  • the barrier container 40 is closed by joining the upper edges of the films 41a-41d together to block the opening 40a.
  • the bonding may be performed using a bonding material such as an adhesive or an adhesive, or may be performed by welding such as heat sealing or ultrasonic bonding.
  • the barrier container 40 becomes airtight by being closed.
  • a gas having a volume smaller than the maximum possible volume of the inside of the barrier container 40 minus the volume of the liquid-filled container 30L is enclosed.
  • the barrier container 40 is closed after the gas is discharged from the inside of the barrier container 40 .
  • the barrier container 40 can be closed in a state in which a gas having a volume smaller than the maximum volume that the inside of the barrier container 40 can take minus the volume of the liquid-filled container 30L is enclosed.
  • the barrier container 40 it is preferable to close the barrier container 40 after evacuating from the inside of the barrier container 40 5% or more of the maximum volume of the barrier container 40 . It is more preferable to discharge a gas having a volume of 10% or more, more preferably 20% or more, of the maximum volume that can be taken inside the barrier container 40 from the inside of the barrier container 40. .
  • the following effects are obtained by sealing a volume of gas smaller than the maximum volume that can be taken inside the barrier container 40 minus the volume of the liquid container 30L.
  • the rate of decrease in the oxygen concentration in the headspace HS and the rate of decrease in the amount of dissolved oxygen in the liquid L can be increased. Also, the volume of the space formed between the barrier container 40 and the container 30 is reduced.
  • the barrier property The oxygen reactive agent 20 can be more stably held in the space formed between the container 40 and the container 30 .
  • the process up to closing the barrier container 40 may be performed in an aseptic environment. That is, the aseptically manufactured liquid-filled container 30L, the sterilized or aseptically manufactured barrier container 40 and the oxygen reactive agent 20 such as the oxygen scavenger 21 are placed in a sterile environment such as a sterile chamber. brought down. Under a sterile environment, the barrier container 40 containing the liquid-filled container 30L is closed. The inside of the barrier container 40 containing the liquid-filled container 30L also becomes sterile. That is, the liquid-filled container 30L can be stored in the barrier container 40 in an aseptic state.
  • the barrier container 40 has oxygen barrier properties. Oxygen in the environment in which the barrier container 40 is placed is suppressed from moving into the barrier container 40 .
  • the oxygen scavenger 21 absorbs oxygen within the barrier container 40 . Therefore, the oxygen concentration (%) inside the barrier container 40 outside the container 30 is reduced by the absorption of oxygen by the oxygen scavenger 21 and becomes lower than the oxygen concentration (%) inside the container 30 .
  • the container 30 has oxygen permeability. Therefore, oxygen in container 30 permeates container 30 and moves into barrier container 40 . As the oxygen moves from the container 30 to the barrier container 40, the oxygen concentration in the container 30 decreases.
  • the oxygen content of the container 30 housed in the barrier container 40 can be adjusted.
  • the oxygen concentration within container 30 may match the oxygen concentration within barrier container 40 .
  • the oxygen partial pressure within the container 30 decreases.
  • the saturation solubility (mg/L) of oxygen in the liquid L within the container 30 also decreases.
  • the oxygen dissolution amount (mg/L) of the liquid L can be reduced.
  • the adjustment of the oxygen content of the container 30 within the barrier container 40 may be carried out until the permeation of oxygen through the container 30 is balanced.
  • the adjustment of the oxygen content of the container 30 within the barrier container 40 may be performed until the oxygen concentration (%) within the container 30 decreases to a predetermined value.
  • the oxygen content of the container 30 in the barrier container 40 may be adjusted until the dissolved oxygen amount (mg/L) of the liquid L in the container 30 decreases to a predetermined value.
  • the adjustment of the oxygen content of the container 30 in the barrier container 40 may be carried out until the liquid L of the liquid-filled combination container 10L is used. Further, while the oxygen content of the container 30 is being adjusted within the barrier container 40, the liquid-filled combination container 10L may be circulated.
  • Whether the oxygen permeation through the container 30 is in equilibrium can be determined based on the oxygen concentration in the container 30 measured in the inspection process described later. For this judgment, the difference between the oxygen concentration value (%) in the container 30 at a certain point and the oxygen concentration value (%) in the container 30 24 hours before the certain point is If the oxygen concentration value (%) in the container 30 is ⁇ 5% or less, it is determined that an equilibrium state has been reached.
  • a gap G is formed between the oxygen-permeable stopper 34 of the container 30 housed in the barrier container 40 and the barrier container 40 . According to this example, it is possible to prevent the oxygen barrier container 40 from covering the oxygen permeable plug 34 . As a result, it is possible to prevent the oxygen permeation of the container 30 from being hindered by the barrier container 40 . Therefore, by providing the gap G, it is possible to promote the reduction of the amount of oxygen in the container 30 .
  • the gap G can be secured.
  • the barrier container 40 is made of a flexible material such as a resin film, the gap G between the plug 34 and the barrier container 40 can be formed by adjusting the shape of the barrier container 40. .
  • the method for manufacturing the liquid-filled combination container 10L may include an inspection step of inspecting the liquid-filled combination container 10L by the inspection method described above.
  • the inspection process for inspecting the oxygen concentration in the container 30 by the above-described inspection method is performed to complete the manufacture of the liquid-filled combination container 10L. good too.
  • the oxygen concentration (%) in the container 30 is measured by the inspection method described above, and the oxygen concentration (%) in the container 30 is sufficiently high. It may be checked whether it has been reduced. Also, the change in oxygen concentration (%) in the container 30 over time is obtained, and the amount of dissolved oxygen (mg/L) in the liquid L is sufficiently reduced based on the change in oxygen concentration (%) in the container 30 over time. You may check whether Alternatively, the rate of decrease of the oxygen concentration (%) in the container 30 may be calculated based on the change in the oxygen concentration (%) in the container 30 over time, and it may be inspected whether the rate of decrease is sufficiently high.
  • the manufacturing method of the liquid-filled combination container 10L includes a step of closing the barrier container 40 containing the container 30 and a step of adjusting the amount of oxygen in the container 30 contained in the barrier container 40. At least one oxygen-reactive agent 20 capable of reacting with oxygen within the barrier container 40 is then provided. As an example, an oxygen scavenger 21 that absorbs oxygen in the barrier container 40 is provided. In the process of adjusting the amount of oxygen, the oxygen in the container 30 permeates through the container 30, so that the concentration of oxygen in the container 30 decreases and the amount of oxygen dissolved in the liquid L can be reduced.
  • the oxygen concentration in the container 30 can be reduced to, for example, less than 0.3%, 0.1% or less, 0.05% or less, 0.03% or less, or even 0%.
  • the oxygen concentration in the barrier container 40 and the oxygen concentration in the container 30 can be sufficiently reduced, for example, less than 0.3%, less than 0.1%, less than 0.05%, less than 0.05%, and less than 0.1%. It can be reduced to less than 0.3% or even 0%.
  • the amount of oxygen dissolved in the liquid L in the container 30 can be sufficiently reduced, for example, less than 0.15 mg/L, 0.04 mg/L or less, preferably 0.03 mg/L or less, more preferably 0.02 mg/L.
  • the oxygen absorber 21 can be placed outside the container 30 , the oxygen absorber 21 does not impair the sterility inside the container 30 .
  • Liquid L can be decomposed by oxygen.
  • the solvent of liquid L as an aqueous solution can be decomposed by oxygen.
  • Solid matter such as particles contained in liquid L as a suspension can be decomposed by oxygen. Decomposition by oxygen becomes a more prominent problem in liquids L such as foods and medicines. Highly sensitive liquid L is easily decomposed by oxygen.
  • the oxygen concentration in the container 30 can be sufficiently reduced as described above.
  • the amount of dissolved oxygen in the liquid L contained in the container 30 can be sufficiently reduced.
  • the amount of oxygen in the container 30, that is, the total amount of oxygen in the headspace HS and oxygen dissolved in the liquid L can be reduced. Thereby, decomposition of the liquid L by oxygen can be suppressed.
  • the oxygen concentration in the space not occupied by the liquid L in the container 30, that is, the headspace HS shown in FIGS. , or by bubbling the liquid L with an inert gas, etc. it can be reduced to about 1.5% or less.
  • the oxygen concentration in the headspace HS decreases to 0.5% or more and 1% or less.
  • by producing a liquid in an atmosphere replaced with an inert gas and storing the liquid in a container having an oxygen barrier property it is possible to reduce the amount of dissolved oxygen in the liquid stored in the container. Conceivable.
  • installing the entire liquid manufacturing line in an atmosphere replaced with an inert gas requires large-scale renovation of manufacturing equipment and a huge capital investment.
  • the container 30 containing the liquid L can be manufactured using existing equipment and the like without significantly changing the conventional method. Therefore, equipment repair and equipment investment can be avoided.
  • the container 30 is not subject to any special restrictions. Therefore, materials such as glass and resin, which are widely used as containers for foods, medicines, etc. due to their low elution amount, can be used.
  • the material of the container body 32 is glass, for example.
  • the material of the container body 32 is polyethylene, polypropylene, or the like.
  • the barrier container 40 When using the liquid L stored in the combination container 10, first, the barrier container 40 is opened. Next, the liquid-filled container 30L is taken out from the barrier container 40 that has been opened. After that, the liquid L can be taken out from the liquid container 30L and used. For the illustrated container 30 , the container 30 can be opened by removing the fasteners 36 from the container body 32 and removing the stopper 34 from the container body 32 . Thereby, the liquid L in the container 30 can be used.
  • the liquid L may be a chemical injected into the syringe 60.
  • the liquid L may be a liquid contained in a container 30, which is a vial bottle.
  • the liquid L may be an injection of drugs. Examples of injections include anticancer agents, antiviral agents, vaccines, antipsychotic agents, and the like.
  • Syringe 60 includes cylinder 62 and piston 66 .
  • the cylinder 62 has a cylinder body 63 and a needle 64 projecting from the cylinder body 63 .
  • a tubular needle 64 allows access to the space for containing the liquid L in the cylinder body 63 .
  • the piston 66 has a piston body 67 and a gasket 68 retained on the piston body 67 .
  • Gasket 68 may be made of rubber or the like.
  • the gasket 68 is inserted into the cylinder body 63 to partition the housing space for the liquid L within the cylinder body 63 .
  • the liquid L injected into the syringe 60 may be transferred from the syringe 60 to another syringe, container, or the like before being administered to a patient or the like. In this instance, it may be administered to the patient from a separate syringe, container, or the like.
  • the pressure inside the liquid container 30L may be adjusted.
  • the pressure inside the liquid container 30L may be kept low.
  • the pressure inside the liquid container 30L may be maintained at a negative pressure. According to this example, unintended leakage of the liquid during storage of the liquid-filled container 30L and scattering of the liquid L when the container 30 is opened can be effectively suppressed. Leakage and splashing problems are exacerbated with toxic liquids, such as highly pharmacologically active drugs.
  • Highly sensitive liquids such as foods and drugs, more specifically anticancer agents, antiviral agents, vaccines, antipsychotics, etc. is manufactured and packaged in a sterile environment. That is, liquids to which terminal sterilization cannot be applied are produced by aseptic procedures. A sterile environment by aseptic technique is usually maintained at a positive pressure to inhibit bacterial invasion. Therefore, the pressure inside the container containing the liquid L becomes a predetermined positive pressure corresponding to the sterile environment.
  • the liquid-filled container 30L is stored within the barrier container 40 .
  • oxygen in container 30 permeates container 30 and moves into barrier container 40 .
  • Oxygen permeation can reduce the pressure in the container 30 . That is, the pressure of the container 30 containing the liquid L can be adjusted after the container 30 is closed and the liquid L is enclosed.
  • the inspection method of the first embodiment includes a fluorescence measurement step of irradiating the fluorescent material 27 provided on the inner surface 30 a of the container 30 with light and measuring the fluorescence time or fluorescence intensity of the fluorescent material 27 . It also has a measurement step of measuring the oxygen concentration in the container 30 based on the fluorescence time or fluorescence intensity of the fluorescent material 27 measured in the fluorescence measurement step. Thereby, the oxygen concentration in the container 30 can be measured and inspected without opening the container 30 .
  • the detection device 80 having the illumination unit 81 and the sensor unit 82 is in contact with the portion of the barrier container 40 that is in contact with the fluorescent material installation position 39
  • the illumination unit 81 is used to irradiate the fluorescent material 27 with light
  • the sensor unit 82 is used to measure the fluorescence time or fluorescence intensity of the fluorescent material 27 .
  • the positional relationship among the fluorescent material 27, the illumination section 81, and the sensor section 82 is determined by the detection device 80 being in contact with the portion of the barrier container 40 that is in contact with the fluorescent material installation position 39.
  • the fluorescent material 27, the illumination section 81, and the sensor section 82 can be arranged in the same positional relation at the time of measurement. Further, when measuring the oxygen concentration in the container 30 of the plurality of liquid-filled combination containers 10L, the positional relationship of the fluorescent material 27, the illumination unit 81 and the sensor unit 82 at the time of measurement can be aligned. As a result, when measuring the oxygen concentration in the container 30 of the same liquid-filled combination container 10L at a plurality of times, or when measuring the oxygen concentration in the container 30 of a plurality of liquid-filled combination containers 10L, Measurement conditions can be arranged. This can improve the measurement accuracy of the oxygen concentration. In addition, since the detection device 80 is in contact with the portion of the barrier container 40 that is in contact with the fluorescent material installation position 39, oxygen can be Concentration can be measured. This can improve the measurement accuracy of the oxygen concentration.
  • the detecting device 80 is brought into contact with the deformable barrier container 40, and the barrier container 40 is pushed by the detecting device 80 so that the outer surface of the fluorescent material installation position 39 of the container 30 is exposed.
  • the step of contacting 30b is further provided.
  • the barrier container 40 is brought into contact with the fluorescent material installation position 39 of the container 30 .
  • the detection device 80 is brought into contact with the portion of the barrier container 40 that is in contact with the fluorescent material installation position 39 . Thereby, the positional relationship among the fluorescent material 27, the illumination section 81, and the sensor section 82 is determined as described above.
  • the liquid-filled combination container 10L of the first embodiment is inspected by the inspection method described above.
  • the oxygen concentration in the container 30 can be measured and inspected without opening the container 30, and then the liquid-filled combination container 10L can be manufactured.
  • the liquid-filled container 30 ⁇ /b>L and the liquid-filled combination container 10 ⁇ /b>L of the first embodiment are provided with the fluorescent material 27 provided on the inner surface 30 a of the container 30 . Therefore, the oxygen concentration in the container 30 can be measured and inspected by the inspection method described above without opening the container 30 . Also, the oxygen concentration in the container 30 can be measured and inspected without opening the barrier container 40 .
  • the oxygen reactant 20 is fixed to at least one of the outer surface 30 b of the container 30 and the inner surface of the barrier container 40 .
  • This effect will be explained.
  • the oxygen reactant 20 is not fixed to either the outer surface 30 b of the container 30 or the inner surface of the barrier container 40 .
  • the oxygen-reacting agent 20 does not emit the light that causes the fluorescent material 27 to fluoresce.
  • the oxygen reactive agent 20 of the first embodiment is fixed to at least one of the outer surface 30b of the container 30 and the inner surface of the barrier container 40 . As a result, the oxygen reactive agent 20 can be prevented from moving to a position that hinders the irradiation of the fluorescent material 27 with light.
  • the oxygen-reactive agent 20 by fixing the oxygen-reactive agent 20 at a position that does not interfere with the irradiation of the fluorescent material 27 with the light that causes the fluorescent material 27 to fluoresce, the light can be irradiated onto the fluorescent material 27 without being blocked by the oxygen-reactive agent 20 .
  • the fluorescent material 27 is provided on the inner surface 30 a of the fluorescent material installation position 39 away from the contact area 31 a of the housing portion 31 of the container 30 . Therefore, it is possible to suppress the decrease in measurement accuracy of the oxygen concentration in the gas contained in the head space HS of the container 30 due to the presence of the liquid L contained in the containing portion 31 around the fluorescent material 27. .
  • the container 30 has a coating layer 38 that constitutes the inner surface 30 a of the container 30 and suppresses the adhesion of the liquid L to the inner surface 30 a of the container 30 .
  • the container 30 contains at least one material of glass and cyclic olefin polymer.
  • the above-described materials have a low intensity of fluorescence of the material itself generated by irradiation with light, ie, autofluorescence.
  • the intensity of autofluorescence generated by irradiation with green light having a wavelength of 525 nm is small. Therefore, by using the above-described material as the material of the container 30, it is possible to prevent the accuracy of measuring the fluorescence time or fluorescence intensity of the fluorescent material 27 from deteriorating due to the autofluorescence of the material of the container 30. This can improve the measurement accuracy of the oxygen concentration.
  • Glass has a particularly low intensity of autofluorescence. For this reason, it is particularly preferred that container 30 comprises glass. Since the container 30 contains glass, it is possible to more effectively suppress deterioration in the accuracy of measuring the fluorescence time or fluorescence intensity of the fluorescent material 27 .
  • the barrier container 40 contains at least one of acrylic resin and polyethylene terephthalate resin.
  • the oxygen barrier property of the barrier container 40 can be ensured.
  • the thickness of the wall surface of the barrier container 40 can be reduced. Therefore, it becomes easy to ensure the transparency of the barrier container 40 . Therefore, the fluorescent material 27 can be efficiently irradiated with light from the outside of the barrier container 40 .
  • the fluorescence time or fluorescence intensity of the fluorescent material 27 can be accurately measured from the outside of the barrier container 40 .
  • the above materials have a low intensity of autofluorescence.
  • the intensity of autofluorescence generated by irradiation with green light having a wavelength of 525 nm is low. Therefore, by using the above-mentioned material as the material of the barrier container 40, the accuracy of measuring the fluorescence time or the fluorescence intensity of the fluorescent material 27 is reduced due to the autofluorescence of the material of the barrier container 40. can be suppressed. This can improve the measurement accuracy of the oxygen concentration.
  • the adhesive layer 28 that bonds the fluorescent material 27 to the inner surface 30a of the container 30 is made of at least one resin selected from the group consisting of non-fluorescent photocurable acrylic resins, photocurable silicone resins, and epoxy resins. including.
  • the transparency of the adhesive layer 28 can be ensured. Therefore, the fluorescent material 27 can be efficiently irradiated with light through the adhesive layer 28 . Also, the fluorescence time or fluorescence intensity of the fluorescent material 27 can be measured with high accuracy through the adhesive layer 28 .
  • the adhesive layer 28 satisfies the standards for extractable substances from polyethylene or polypropylene water-based injection containers when conducting the extractable substance test of the plastic drug container test method specified in the 18th revision of the Japanese Pharmacopoeia. meet. That is, when the extractables test of the plastic drug container test method specified in the Japanese Pharmacopoeia is conducted, the generated foam almost disappears within 3 minutes in the foaming test. Also, in the pH test, the difference between the test liquid and the blank test liquid is 1.5 or less.
  • the difference in consumption of the 0.002 mol/L potassium permanganate solution was 1.0 ml or less.
  • the absorbance at a wavelength of 220 nm or more and less than 241 nm is 0.08 or less, and the absorbance at a wavelength of 241 nm or more and 350 nm or less is 0.05 or less.
  • the mass of the evaporation residue is 1.0 mg or less.
  • the materials described above are materials that can be used in vivo, such as humans, and are used as medical adhesives.
  • the above-mentioned materials are said to have little effect on the living body even when used as an adhesive in the living body of a human being, etc., and dissolved in the liquid in the living body. Therefore, by using the above-described material as the material of the adhesive layer 28, even if the material of the adhesive layer 28 dissolves into the liquid L, the liquid L caused by the elution of the adhesive layer 28 or a living body that ingests the liquid L can be used.
  • the elution of the adhesive layer 28 can reduce the effects on the liquid L and the living body that ingests the liquid L.
  • Photo-curing acrylic resins that do not fluoresce are said to have little effect on living organisms.
  • the adhesive layer 28 it is particularly preferable for the adhesive layer 28 to contain a photocurable acrylic resin that does not fluoresce. Since the container 30 contains a photocurable acrylic resin that does not fluoresce, the effects of the elution of the adhesive layer 28 on the liquid L and the living body that ingests the liquid L can be reduced more effectively.
  • the materials described above have a low fluorescence intensity of the material itself, such as the autofluorescence of the resin contained in the material.
  • the fluorescence intensity of the material itself which is generated by being irradiated with green light having a wavelength of 525 nm, is low. Therefore, by using the above-described material as the material of the adhesive layer 28, it is possible to suppress the decrease in the accuracy of measuring the fluorescence time or the fluorescence intensity of the fluorescent material 27 due to the autofluorescence of the material of the adhesive layer 28. .
  • the container 30 is transparent at least at the fluorescent material installation position 39 .
  • the barrier container 40 is transparent at least at the portion in contact with the outer surface 30b of the fluorescent material installation position 39. As shown in FIG. Thereby, the fluorescent material 27 can be efficiently irradiated with light through the container 30 and the barrier container 40 .
  • Modification 1 In the first embodiment described above, the barrier container 40 is pushed by the detection device 80 to bring the barrier container 40 into contact with the outer surface 30b of the fluorescent material installation position 39 of the container 30. A method for inspecting the container 10L is shown. However, the method of bringing the barrier container 40 into contact with the outer surface 30b of the fluorescent material installation position 39 of the container 30 is not limited to this.
  • FIG. 13 is a diagram showing an example of a state in which the barrier container 40 is brought into contact with the outer surface 30b of the fluorescent material installation position 39 of the container 30 in the inspection method for the liquid-filled combination container 10L of Modification 1.
  • FIG. 14 is a view showing another example of a state in which the barrier container 40 is brought into contact with the outer surface 30b of the fluorescent material installation position 39 of the container 30 in the inspection method for the liquid-filled combination container 10L of Modification 1.
  • the liquid-filled combination container 10L shown in FIGS. 13 and 14 includes the liquid-filled container 30L shown in FIGS. 1 and 2, and the barrier container 40 shown in FIG. 4 that accommodates the liquid-filled container 30L.
  • FIG. 13 and 14 correspond to cross-sectional views of the liquid-filled combination container 10L with the barrier container 40 in contact with the outer surface 30b of the fluorescent material installation position 39 of the container 30.
  • FIG. in the example shown in FIGS. 13 and 14 the liquid-filled combination container 10L comprises one oxygen reactant 20.
  • oxygen reactant 20 is oxygen scavenger 21 .
  • the oxygen reactant 20 is fixed to the inner surface of the barrier container 40 .
  • the oxygen reactant 20 is secured to the outer surface 30b of the container 30.
  • oxygen reactant 20 is secured to stopper 34 of container 30 .
  • the liquid-filled combination container 10L further includes a shrink film 91 wrapped around the barrier container 40 so as to cover the fluorescent material installation position 39 of the container 30 .
  • the shrink film 91 is a heat-shrinkable resin film.
  • the material of the shrink film 91 is, for example, polystyrene, polypropylene, polyethylene polyethylene terephthalate or polyvinyl chloride.
  • heat is applied to the shrink film 91 wrapped around the outer circumference of the barrier container 40 to cause the shrink film 91 to thermally shrink. 39 is in contact with the outer surface 30b.
  • the barrier container 40 is fixed to the container 30 by the shrink film 91.
  • the barrier container 40 is brought into contact with the outer surface 30b of the fluorescent material installation position 39 of the container 30 by evacuating the inside of the barrier container 40 into a vacuum.
  • the barrier container 40 is fixed to the container 30 by deairing the inside of the barrier container 40 .
  • wrinkles not be formed in the portion of the barrier container 40 that is in contact with the outer surface 30b of the fluorescent material installation position 39 of the container 30 . Since wrinkles are not formed, it is possible to suppress a decrease in oxygen concentration measurement accuracy due to wrinkles. For example, it is possible to prevent the wrinkles of the relevant portion from causing irregular reflection of the light emitted to the fluorescent material 27 or the fluorescent light of the fluorescent material 27, which may reduce the measurement accuracy of the oxygen concentration.
  • the operation of bringing the barrier container 40 into contact with the outer surface 30b of the fluorescent material installation position 39 of the container 30 is, for example, the operation of wrapping a shrink film 91 around the barrier container 40 and applying heat, or degassing the inside of the barrier container 40. It is an operation to make a vacuum.
  • the oxygen content is adjusted. If it is envisaged to carry out the process, the following points may be noted. Care should be taken so that oxygen transfer between the oxygen-permeable portion of the container 30 and the oxygen-reactive agent 20 is not hindered by bringing the barrier container 40 into contact with the outer surface 30 b of the fluorescent material installation position 39 of the container 30 .
  • the oxygen reactive agent 20 is the oxygen scavenger 21
  • the oxygen permeated through the oxygen-permeable portion of the container 30 can be quickly reduced by the oxygen absorption of the oxygen scavenger 21 .
  • the oxygen reactant 20 is the oxygen detecting material 25
  • the oxygen state of the space in the barrier container 40 into which oxygen permeates the oxygen-permeable portion of the container 30 is measured by the oxygen detecting material 25. can be detected by In the example shown in FIG. 13, the barrier container 40 is in contact with the outer surface 30b of the container 30 over the entire circumference of the container 30 including the fluorescent material installation position 39.
  • FIG. 13 the example shown in FIG.
  • the closure 34 of the container 30 is permeable to oxygen.
  • a plug 34, which is the oxygen-permeable portion of the container 30, is located in the first space S1.
  • the oxygen reactant 20 may be placed in the first space S1. In this case, oxygen transfer between the oxygen-permeable portion of container 30 and oxygen-reactive agent 20 is not impeded.
  • oxygen reactant 20 is oxygen scavenger 21 .
  • the oxygen that permeates the oxygen-permeable portion of the container 30 can be rapidly reduced by the oxygen absorption of the oxygen scavenger 21 .
  • the oxygen reactant 20 when the oxygen reactant 20 is arranged in the second space S2, there is a gap between the barrier container 40 and the container 30 connecting the first space S1 and the second space S2.
  • the barrier container 40 may be in contact with the outer surface 30b of the fluorescent material placement location 39 of the container 30 so as to remain. In this case as well, it is possible to suppress the obstruction of oxygen transfer between the oxygen-permeable portion of the container 30 and the oxygen-reactive agent 20 .
  • the oxygen reactive agent 20 is the oxygen scavenger 21
  • the oxygen that has permeated through the oxygen-permeable portion of the container 30 can be rapidly reduced by the oxygen absorption of the oxygen scavenger 21 .
  • FIG. 15 is a view showing a liquid-filled combination container 10L of Modification 2. As shown in FIG. FIG. 15 corresponds to a cross-sectional view of the liquid-filled combination container 10L with the barrier container 40 in contact with the outer surface 30b of the fluorescent material installation position 39 of the container 30.
  • FIG. 15 corresponds to a cross-sectional view of the liquid-filled combination container 10L with the barrier container 40 in contact with the outer surface 30b of the fluorescent material installation position 39 of the container 30.
  • the barrier container 40 of the liquid-filled combination container 10L shown in FIG. 15 does not have deformable flexibility.
  • the barrier container 40 shown in FIG. 15 is a vial.
  • the barrier container 40 has a container body 42 and a lid 44 inserted into an opening 45 of the container body 42 .
  • the material of the container body 42 is, for example, glass or resin.
  • the container body 42 may be a glass bottle.
  • the opening 45 of the container body 42 has a size that allows the container 30 to be accommodated in the container body 42 .
  • the liquid-filled container 30L of the liquid-filled combination container 10L shown in FIG. 15 is similar to the liquid-filled container 30L shown in FIGS.
  • the liquid-filled combination container 10L comprises one oxygen reactant 20.
  • FIG. 15 the example shown in FIG.
  • oxygen reactant 20 is oxygen scavenger 21 .
  • the oxygen reactant 20 is secured to the outer surface 30b of the container 30.
  • oxygen reactant 20 is secured to stopper 34 of container 30 .
  • the barrier container 40 shown in FIG. 15 is designed so that when the container 30 is housed in the barrier container 40, the barrier container 40 naturally comes into contact with the outer surface 30b of the fluorescent material installation position 39 of the container 30.
  • the container 30 is a vial having a glass container body 32 and a stopper 34 .
  • the container 30 has a substantially cylindrical outer shape.
  • the barrier container 40 has a substantially cylindrical outer shape. 15, the outer diameter w1 of the container 30 matches the inner diameter w2 of the barrier container 40. As shown in FIG. Therefore, when the container 30 is accommodated in the barrier container 40 , the barrier container 40 naturally contacts the outer surface 30 b of the fluorescent material installation position 39 of the container 30 .
  • the container 30 of the liquid-filled combination container 10L is in a stationary state, particularly in an upright state. In this state, horizontal movement of the container 30 is suppressed by the barrier container 40 . In addition, movement of the container 30 in the vertical direction is suppressed by the barrier container 40 .
  • the barrier container 40 is fixed to the container 30 using the effect of gravity by housing the container 30 in the barrier container 40 .
  • the barrier container 40 shown in FIG. 15 can stably maintain a state in which the barrier container 40 is in contact with the outer surface 30b of the fluorescent material installation position 39 of the container 30, in particular.
  • the detection device 80 by bringing the detection device 80 into contact with the portion of the barrier container 40 that contacts the fluorescent material installation position 39, the positions of the fluorescent material 27, the illumination unit 81, and the sensor unit 82 are detected. relationship is defined.
  • the barrier container 40 shown in FIG. 15 does not have deformable flexibility, it is possible to store the gas while maintaining the negative pressure in the atmosphere. Being able to hold a gas under atmospheric pressure while maintaining a negative pressure means that the gas can be held without damage while the internal pressure is kept at a negative pressure of 0.80 atm or more.
  • the barrier container 40 which can hold gas under atmospheric pressure while maintaining a negative pressure, may be in an airtight state when the internal pressure is 0.80 atm.
  • a container that can hold gas under atmospheric pressure while maintaining a negative pressure may be able to maintain the volume when the internal pressure is 0.80 atm to 95% or more of the volume when the internal pressure is 1.0 atm. .
  • the barrier container 40 may be capable of containing the gas under atmospheric pressure while maintaining the gas at a positive pressure.
  • the phrase "capable of accommodating a gas while maintaining a positive pressure under atmospheric pressure” means that the gas can be accommodated without damage while the internal pressure is maintained at a positive pressure of 1.2 atm or more.
  • the barrier container 40 that can contain gas under atmospheric pressure while maintaining a positive pressure may be in an airtight state when the internal pressure is 1.20 atm. In a container that can hold gas under atmospheric pressure while maintaining a positive pressure, the volume when the internal pressure is 1.2 atm may be maintained at 105% or less of the volume when the internal pressure is 1.0 atm. .
  • the barrier container 40 has sufficient rigidity to maintain its shape. However, the barrier container 40 may be somewhat deformed in the atmosphere when the internal pressure is maintained at negative pressure or positive pressure.
  • the barrier container 40 containing the container 30 is closed under an atmosphere maintained at a negative pressure.
  • the pressure within the closed barrier container 40 will be below atmospheric pressure.
  • permeation of oxygen from the container 30 to the barrier container 40 is promoted.
  • the pressure inside the container 30 can be greatly adjusted.
  • the pressure inside the container 30 which was initially positive can be adjusted to a negative pressure by storing the container 30 inside the barrier container 40 .
  • the pressure-regulated liquid-filled container 30L can be manufactured without depending on the manufacturing method of the liquid L, the environment in which the liquid L is sealed in the container 30, or the like.
  • closing the barrier container 40 under negative pressure promotes oxygen permeation of the container 30 . Therefore, the time from closing the barrier container 40 containing the liquid-filled container 30L to the equilibrium of oxygen permeation through the container 30 can be shortened.
  • Negative pressure means a pressure of less than 1 atm, which is the atmospheric pressure.
  • Positive pressure means pressure above 1 atm, which is atmospheric pressure.
  • Whether or not the pressure inside the container is negative can be determined using the pressure gauge if the container is provided with the pressure gauge. If the container is not equipped with a pressure gauge, it can be determined using a syringe. Specifically, when the target container is pierced with the needle of the syringe, whether the liquid or gas contained in the syringe flows into the container while only the atmospheric pressure is applied to the piston of the syringe. You can judge by whether or not When the liquid or gas contained in the syringe flows into the container, it is determined that the pressure inside the container was negative.
  • whether or not the pressure inside the container is positive can be determined using a pressure gauge, but it can also be determined using a syringe. Specifically, when the target container is pierced with the needle of the syringe, whether the liquid or gas contained in the container flows into the syringe while only the atmospheric pressure is applied to the piston of the syringe. You can judge by whether or not If the liquid or gas contained in the container flows into the syringe, it is determined that the pressure inside the container was positive.
  • Container 30 may be secured to barrier container 40 .
  • the container 30 is fixed to the barrier container 40 so that its position relative to the barrier container 40 does not change even when the orientation of the liquid-filled combination container 10L is changed.
  • the container 30 of the liquid-filled combination container 10L may be fixed to the barrier container 40 by utilizing the action of gravity when the container 30 is standing still, particularly when the container 30 is erected.
  • the container 30 is fixed to the barrier container 40 by a first fixing member 921 different from the container 30 and the barrier container 40 . By fixing the container 30 to the barrier container 40, the outer surface 30b of the fluorescent material installation position 39 of the container 30 may be contacted.
  • FIG. 16 is a diagram showing a liquid-filled combination container 10L of Modification 3.
  • the barrier container 40 of the liquid-filled combination container 10L shown in FIG. 16 is similar to the barrier container 40 shown in FIG. 15 except that the dimensions are different.
  • the liquid-filled container 30L of the liquid-filled combination container 10L shown in FIG. 16 is similar to the liquid-filled container 30L shown in FIGS.
  • the liquid-filled combination container 10L comprises one oxygen reactant 20.
  • oxygen reactant 20 is oxygen scavenger 21 .
  • the oxygen reactant 20 is sandwiched between the outer surface 30b of the container 30 and the inner surface of the barrier container 40.
  • FIG. 16 is a diagram showing a liquid-filled combination container 10L of Modification 3.
  • FIG. 16 The barrier container 40 of the liquid-filled combination container 10L shown in FIG. 16 is similar to the barrier container 40 shown in FIG. 15 except that the dimensions are different.
  • the liquid-filled container 30L of the liquid-filled combination container 10L shown in FIG. 16 is similar to the
  • the container 30 of the liquid-filled combination container 10L is in a stationary state, particularly in an upright state. In this state, vertical movement of the oxygen reactant 20 is suppressed by the action of gravity. Thereby, it is fixed to the outer surface 30 b of the container 30 and the inner surface of the barrier container 40 .
  • the container 30 is fixed to the barrier container 40 by a first fixing member 921 different from the container 30 and the barrier container 40 .
  • the inner diameter w2 of the barrier container 40 is larger than the outer diameter w1 of the container 30.
  • the position of the barrier container 40 with respect to the container 30 is not fixed only by housing the container 30 in the barrier container 40 .
  • the container 30 may be fixed to the barrier container 40 by a first fixing member 921 different from the container 30 and the barrier container 40, as in the example shown in FIG. In the example shown in FIG.
  • the space between the container 30 and the barrier container 40 is occupied by the first fixing member 921, so that the horizontal movement of the barrier container 40 with respect to the container 30 is suppressed.
  • the container 30 of the liquid-filled combination container 10L is in a stationary state, particularly in an upright state. In this state, vertical movement of the barrier container 40 with respect to the container 30 is suppressed by the action of gravity.
  • the container 30 is thereby fixed to the barrier container 40 .
  • the barrier container 40 may be brought into contact with the outer surface 30 b of the fluorescent material installation position 39 of the container 30 .
  • the first fixing member 921 is provided inside the barrier container 40 .
  • the first fixing member 921 is sandwiched between the outer surface 30b of the container 30 and the inner surface of the barrier container 40 to fix the container 30 to the barrier container 40, and the barrier container 40 is attached to the container 30 with the fluorescent material. Contact the outer surface 30b at location 39;
  • the oxygen reactant 20 also serves as the first fixing member 921. That is, the container 30 is fixed to the barrier container 40 by sandwiching the oxygen reactant 20 between the outer surface 30b of the container 30 and the inner surface of the barrier container 40 .
  • the first fixing member 921 may be a member different from the oxygen reactive agent 20 .
  • the container 30 is fixed to the barrier container 40 according to the forms of the container 30 and the barrier container 40, and the barrier container 40 is attached to the outer surface 30b of the fluorescent material installation position 39 of the container 30. A member to be brought into contact is appropriately used.
  • the liquid-filled combination container 10L of the second embodiment stores the liquid L in the storage portion 31, and has an oxygen permeability, similar to the liquid-filled combination container 10L of the first embodiment. 30 and a barrier container 40 having an oxygen barrier property.
  • the liquid-filled combination container 10L of the second embodiment emits laser light or LED light of a wavelength that is attenuated according to the oxygen concentration of the light path LA to the portion of the container 30 away from the contact area 31a of the containing portion 31 of the container 30.
  • the oxygen concentration in the container 30 can be inspected by irradiating the liquid-filled combination container 10L so as to transmit the laser light or the LED light and measuring the attenuation rate of the laser light or LED light.
  • FIG. 17 is a diagram showing an example of a liquid-filled combination container 10L according to the second embodiment.
  • the liquid-filled combination container 10L shown in FIG. 17 is similar to the liquid-filled combination container 10L shown in FIG. That is, the liquid-filled combination container 10L shown in FIG. 17, the barrier container 40 is in contact with the outer surface 30b of the container 30 due to thermal shrinkage of the shrink film 91 wrapped around the barrier container 40 in the liquid-filled combination container 10L shown in FIG.
  • FIG. 18 is a diagram showing another example of the liquid-filled combination container 10L of the second embodiment.
  • the liquid-filled combination container 10L shown in FIG. 18 is similar to the liquid-filled combination container 10L shown in FIG. That is, in the combination container 10L containing liquid shown in FIG.
  • the container 30 has a first position 35a and a second position 35b remote from the contact area 31a of the container 31.
  • the container 30 is optically transmissive at least at the first position 35a and the second position 35b.
  • the barrier container 40 has optical transparency at least at positions intersecting a straight line connecting the first position 35a and the second position 35b.
  • the straight line indicating the optical path LA corresponds to the straight line connecting the first position 35a and the second position 35b.
  • the barrier container 40 has optical transparency at least at positions intersecting the straight line indicating the optical path LA. 17 and 18, barrier container 40 contacts outer surface 30b of container 30 at first location 35a and second location 35b.
  • the barrier container 40 contacts the outer surface 30b of the container 30 at the first location 35a and the second location 35b at locations that are light transmissive.
  • the liquid-filled combination container 10L can be irradiated with laser light or LED light so as to pass through the first position 35a and the second position 35b of the container 30, and the attenuation rate of the laser light or LED light can be measured.
  • a dashed line in the drawing indicates an optical path LA of laser light or LED light.
  • the barrier container 40 is positioned away from the contact area 31a of the housing portion 31 of the container 30 and above the contact area 31a. It is in contact with the container 30 over the entire circumference. In other words, the barrier container 40 is in contact with the container 30 over the entire circumference of the container 30 at the position where the container 30 contacts the headspace HS.
  • the first position 35a and the second position 35b are defined as follows. An arbitrary position away from the contact area 31a of the housing portion 31 of the container 30 and in contact with the barrier container 40 is defined as the first position 35a.
  • a position is defined as a second position 35b.
  • the first position 35a and the second position 35b are defined to sandwich the headspace HS.
  • the optical path LA of the laser light or LED light passing through the first position 35a and the second position 35b is perpendicular to the wall surface of the container 30 at the first position 35a and perpendicular to the walls of container 30 at 35b.
  • the first position 35a and the second position 35b are such that the optical path LA of the laser light or LED light passing through the first position 35a and the second position 35b is perpendicular to the wall surface of the container 30 at the first position 35a, and It is positioned perpendicular to the wall surface of the container 30 at the second position 35b.
  • the liquid-filled combination container 10L of the second embodiment further comprises at least one oxygen reactive agent 20 capable of reacting with oxygen in the barrier container 40.
  • the oxygen reactive agent 20 is fixed to at least one of the outer surface 30 b of the container 30 and the inner surface of the barrier container 40 .
  • the liquid-filled combination container 10L comprises one oxygen reactant 20.
  • oxygen reactive agent 20 is oxygen scavenger 21 .
  • the oxygen reactant 20 is fixed to the inner surface of the barrier container 40 .
  • the oxygen reactant 20 is secured to the outer surface 30b of the container 30.
  • oxygen reactant 20 is secured to stopper 34 of container 30 .
  • the oxygen reactive agent 20 of the second embodiment is used when the oxygen concentration in the container 30 is inspected in the method for inspecting the liquid-filled combination container 10L, which will be described later. It is fixed at a position that does not hinder transmission through the second position 35b.
  • the oxygen reactant 20 of the second embodiment is separated from the straight line connecting the first position 35a and the second position 35b.
  • the straight line indicating the optical path LA corresponds to the straight line connecting the first position 35a and the second position 35b.
  • the oxygen reactant 20 is separated from the straight line indicating the optical path LA.
  • the oxygen reactant 20 is not located on a straight line connecting the first position 35a and the second position 35b. Accordingly, by setting the straight line connecting the first position 35a and the second position 35b as the optical path LA, the laser light or the LED light can be irradiated so as to pass through the container 30.
  • the oxygen reactant 20 when fixing the oxygen reactant 20 to the outer surface 30b of the container 30, the oxygen reactant 20 is fixed to the outer surface 30b of the container 30 at a position that does not overlap the first position 35a and the second position 35b.
  • the oxygen-reactive agent 20 when the oxygen-reactive agent 20 is fixed to the inner surface of the barrier container 40 , the oxygen-reactive agent 20 is positioned on the inner surface of the barrier container 40 in a direction perpendicular to the inner surface of the barrier container 40 at the first position 35 a and the second position 35 a . It is fixed at a position that does not overlap the second position 35b.
  • the positional relationship between the container 30 and the oxygen reactant 20 may be determined.
  • the defined positional relationship between the container 30 and the oxygen reactant 20 means that relative movement of the oxygen reactant 20 with respect to the container 30 is suppressed.
  • the positional relationship between the container 30 and the oxygen reactant 20 is determined by fixing the oxygen reactant 20 to the outer surface 30b of the container 30 .
  • the oxygen-reactive agent 20 is fixed to the inner surface of the barrier container 40, and the container 30 is fixed to the barrier container 40 as described later. A positional relationship with the oxygen reactant 20 is defined.
  • the oxygen reactant 20 is located on the second surface 34f side of the plug 34.
  • the liquid-filled combination container 10L is placed on the placement surface with the container 30 standing upright. In other words, the liquid-filled combination container 10L is placed on the mounting surface with the opening 33 of the container body 32 facing upward.
  • oxygen reactant 20 is positioned above plug 34 .
  • the inspection method for inspecting the oxygen concentration in the container 30 of the liquid-filled combination container 10L of the second embodiment includes an attenuation rate measurement step and a measurement step.
  • the inspection method for inspecting the oxygen concentration in the container 30 of the liquid-filled combination container 10L further comprises the step of bringing the barrier container 40 into contact with the outer surface 30b of the container 30 at the first position 35a and the second position 35b.
  • the inspection method for inspecting the oxygen concentration in the container 30 of the liquid-filled combination container 10L further includes a first standard sample measurement step and a second standard sample measurement step.
  • the shrink film 91 is wrapped around the barrier container 40 and heat is applied, or the barrier container 40 is heated. Perform operations such as degassing the inside of the to create a vacuum.
  • the barrier container 40 contacts the outer surface 30b of the first position 35a and the second position 35b of the container 30, as in the example shown in FIG. do.
  • the barrier container 40 contacts the outer surface 30b of the container 30 at the first position 35a and the second position 35b, as in the example shown in FIG. do.
  • the barrier container 40 is brought into contact with the outer surface 30b of the container 30 at the first position 35a and the second position 35b at positions having light transmission properties.
  • the specific method of bringing the barrier container 40 into contact with the outer surface 30b of the first position 35a and the second position 35b of the container 30 is not limited to the above-described example.
  • the method of contacting the outer surface 30b at two locations 35b can be widely adopted.
  • wrinkles not be formed in the portions of the barrier container 40 that come into contact with the outer surface 30b of the container 30 at the first position 35a and the second position 35b. Since wrinkles are not formed, it is possible to suppress deterioration in measurement accuracy of the oxygen concentration due to wrinkles in the measurement step described later. For example, it is possible to prevent the laser light or LED light that passes through the first position 35a and the second position 35b of the container 30 from being irregularly reflected due to wrinkles in the portion, thereby suppressing the decrease in measurement accuracy of the oxygen concentration.
  • the liquid-filled combination container 10L is irradiated with laser light or LED light so as to pass through a portion away from the contact area 31a of the housing portion 31 of the container 30, and the laser light or the LED light is emitted. Measure the attenuation rate.
  • laser light or LED light is applied to the barrier container.
  • Liquid-filled combination container 10L is illuminated through 40 light transmissive locations and first location 35 a and second location 35 b of container 30 .
  • the attenuation rate of laser light or LED light is measured using a measuring device 95.
  • the measuring device 95 has a light source 951 that emits laser light or LED light, and a measuring device 952 that measures the attenuation rate of the laser light or LED light.
  • the measurement of the attenuation rate of laser light or LED light in the attenuation rate measurement step and the measurement of the oxygen concentration in the measurement step described later are performed by a so-called headspace analyzer method.
  • the measuring device 95 is a so-called headspace analyzer.
  • a headspace analyzer As the headspace analyzer, a desktop headspace analyzer may be used, or an in-line headspace analyzer may be used.
  • the desktop headspace analyzer has a size that can be placed on a desk, and a head that can measure the oxygen concentration in the container 30 by manually setting the liquid-filled combination container 10L for measuring the oxygen concentration in the container 30.
  • the in-line type headspace analyzer is a headspace analyzer capable of automatically measuring the oxygen concentration in the container 30 of the produced combination container 10L by incorporating it into the production line for producing the combination container 10L containing liquid.
  • a headspace analyzer used as the measuring device 95 is, for example, a headspace analyzer FMS760 manufactured by Lighthouse.
  • the light source 951 is arranged so that the laser light or the LED light passes through a portion of the housing portion 31 of the container 30 away from the contact area 31a.
  • the measuring device 952 is arranged at a position where the intensity of the laser light or the LED light transmitted through the portion away from the contact area 31a of the housing portion 31 of the container 30 can be measured.
  • measuring device 952 is arranged such that optical path LA of laser light or LED light extends from light source 951 to measuring device 952 .
  • the positional relationship between the light source 951 and the measuring device 952 is determined.
  • a portion of the housing portion 31 of the container 30 away from the contact area 31a is arranged between the light source 951 and the measuring device 952 .
  • the light source 951 is positioned such that laser light or LED light is transmitted through the first position 35a and the second position 35b of the container 30.
  • FIGS. 17 and 18 the example shown in FIGS.
  • the light source 951 is used to irradiate laser light or LED light so as to pass through a portion of the housing portion 31 of the container 30 away from the contact area 31a. Then, using the measuring device 952, the attenuation rate of the laser light or the LED light transmitted through the portion apart from the contact area 31a of the housing portion 31 of the container 30 is measured.
  • Frequency modulation spectroscopy may be used to measure the attenuation rate in the attenuation rate measurement step. That is, frequency modulation is applied to the irradiated laser light or LED light, and the light transmitted through the housing portion 31 of the container 30 is demodulated. rate may be measured.
  • the laser light or LED light irradiated to the liquid-filled combination container 10L has a wavelength that is attenuated according to the oxygen concentration in the optical path LA.
  • the wavelength of laser light or LED light includes wavelengths that are absorbed by oxygen. For this reason, part of the wavelengths included in the wavelengths of the laser light or LED light is absorbed by oxygen, so that the laser light or LED light is attenuated according to the oxygen concentration in the optical path LA.
  • laser light or LED light with a wavelength of 760 nm is absorbed by oxygen. Therefore, the wavelength of laser light or LED light may include a wavelength of 760 nm.
  • the light irradiated to the liquid-filled combination container 10L is Laser light is preferred.
  • Attenuation rate is a value indicating the ratio of the intensity of the laser light or LED light measured by the measuring device 952 to the intensity of the laser light or LED light emitted from the light source 951.
  • the intensity at the wavelength of the laser light or LED light measured by the measuring device 952 with respect to the intensity at the wavelength that is considered to be attenuated according to the oxygen concentration in the optical path LA of the laser light or LED light emitted from the light source 951 The ratio may be measured as a decay rate.
  • the ratio of the intensity of the laser light or LED light at a wavelength of 760 nm measured by the measuring device 952 to the intensity of the laser light or LED light emitted from the light source 951 at a wavelength of 760 nm may be measured as the attenuation rate.
  • the measuring device 952 may measure information other than the intensity of the light emitted from the light source 951 .
  • the measuring device 952 may measure, for example, the difference in amplitude for each cycle and the difference in wavelength for each cycle of the light emitted from the light source 951 .
  • the attenuation rate may be corrected using information other than the intensity measured by measuring device 952 .
  • the oxygen concentration in the container 30 may be measured based on the corrected attenuation factor in the measurement process described later.
  • Measuring the attenuation rate in the attenuation rate measurement process includes measuring a numerical value that changes according to the attenuation rate, for example, a numerical value that is proportional to the attenuation rate. Further, in measuring the oxygen concentration in the container 30 based on the attenuation rate in the measurement step described later, by measuring the oxygen concentration in the container 30 based on the numerical value that changes according to the attenuation rate, includes measuring the oxygen concentration in container 30 based on the decay rate. For example, measuring the oxygen concentration in the container 30 based on the attenuation rate in the measurement process described below includes measuring the oxygen concentration in the container 30 based on a numerical value proportional to the attenuation rate.
  • the attenuation rate measuring step may measure the rate of change of light, including the rate of attenuation of light intensity. "Rate of change of light” is the rate of change of a measurable value for light that is believed to change with the concentration of oxygen in the light path through which the light is directed.
  • the oxygen concentration may be measured based on the rate of change of light.
  • the attenuation factor measurement step may measure changes in amplitude or wavelength of light. Further, in the measurement step, the oxygen concentration may be measured using changes in the amplitude or wavelength of light.
  • the same liquid-filled combination container 10L it may be required to measure the oxygen concentration in the container 30 of the same liquid-filled combination container 10L at a plurality of points in time. For example, when observing the temporal change of the oxygen concentration in the container 30 and judging whether the dissolved amount of oxygen in the liquid L contained in the container 30 is sufficiently reduced, the same liquid-filled combination container 10L It is required to measure the oxygen concentration in the container 30 at multiple points in time. Further, when calculating the decrease rate of the oxygen concentration in the container 30 based on the change in the oxygen concentration in the container 30 over time, the oxygen concentration in the container 30 of the same combination container 10L containing liquid is measured at a plurality of points of time. are required to do so.
  • the container 30, the barrier container 40, the light source 951, and the measuring device 952 have the same positional relationship at the time of attenuation factor measurement.
  • the conditions for measuring the attenuation rate such as the length of the optical path LA of the laser light or the LED light, can be aligned, and the measurement accuracy of the oxygen concentration measured based on the attenuation rate can be improved.
  • laser light or LED light is emitted from the light source 951 and passes through the inside of the container 30 and the outside of the liquid-filled combination container 10L before reaching the measuring device 952.
  • the length of the optical path LA of laser light or LED light can be made uniform. In particular, the distance through which the laser light or LED light travels inside the container 30 is aligned.
  • the laser light or the LED light can be arranged at a distance that passes through the outside of the liquid-filled combination container 10L.
  • the attenuation rate measured in the attenuation rate measurement step varies depending on the difference in the distance that the laser light or LED light passes through the container 30 or the distance that the laser light or the LED light passes outside the liquid-filled combination container 10L. is suppressed.
  • the magnitude of the attenuation rate measured in the attenuation rate measurement step and the magnitude of the oxygen concentration in the container 30 correspond more accurately. As described above, it is possible to improve the measurement accuracy when measuring the oxygen concentration based on the attenuation rate in the measurement step described later.
  • the first standard sample is irradiated with laser light or LED light, and the attenuation rate of the laser light or LED light is measured.
  • Portions of the first standard sample that can be configured in the same manner as the liquid-filled combination container 10L, which is the object of the inspection method, are referred to by the same names, but are given different reference numerals from the corresponding portions of the liquid-filled combination container 10L.
  • FIGS. 17 and 18, reference numerals representing the configuration of the liquid-filled combination container 10L and reference numerals representing the configuration of the first standard sample are attached.
  • the first standard sample includes a container 301 and a barrier container 401 containing the container 301, which is similar to the container 30 of the liquid-filled combination container 10L to be tested and the barrier container 40 containing the container 30.
  • the oxygen concentration inside the first standard sample container 301 is specified.
  • the first standard sample container 301 contains air.
  • the oxygen concentration inside the first standard sample container 301 can be specified as the oxygen concentration of the air. It is generally known that the oxygen concentration of air is close to 20.95%. Therefore, the oxygen concentration inside the container 301 containing the air in the first standard sample can be regarded as 20.95%.
  • the pressure of the air contained in the first standard sample container 301 is equal to the atmospheric pressure.
  • the container 301 for the first standard sample may or may not contain the same liquid L1 as the liquid L contained in the container 31 of the container 30 of the liquid combination container 10L in the container 311. good too.
  • the oxygen concentration in the headspace HS1 of the container 301 may be specified. Specifically, air may be contained in the headspace HS1 of the container 301, and the oxygen concentration of the headspace HS1 of the container 301 may be specified as the oxygen concentration of the air.
  • the oxygen concentration of the entire inside of the container 301 may be specified. Specifically, air may be contained in the entire interior of the container 301, and the oxygen concentration of the entire interior of the container 301 may be specified as the oxygen concentration of the air.
  • the first standard sample is irradiated with laser light or LED light so as to pass through the interior of the container 301, and the attenuation rate of the laser light or LED light is measured.
  • the attenuation rate is measured using the same light source 951 and measurement device 952 as those used in the attenuation rate measurement step.
  • the wavelength of the laser light or LED light irradiated to the first standard sample in the first standard sample measurement step is the same as the wavelength of the laser light or LED light irradiated to the liquid-filled combination container 10L in the attenuation rate measurement step.
  • the first standard sample may be irradiated with laser light or LED light so as to pass through a portion of the housing portion 311 of the container 301 away from the contact region 31a1.
  • the attenuation rate can be measured when the oxygen concentration inside the container 301 is equal to the oxygen concentration in the air.
  • the decay rate can be measured when the oxygen concentration inside the container 301 is 20.95%.
  • the second standard sample is irradiated with laser light or LED light, and the attenuation rate of the laser light or LED light is measured.
  • Portions of the second standard sample that can be configured in the same manner as the liquid-filled combination container 10L, which is the object of the inspection method, are referred to with the same names, but are given different reference numerals from the corresponding portions of the liquid-filled combination container 10L.
  • FIGS. 17 and 18, reference numerals representing the configuration of the liquid-filled combination container 10L and reference numerals representing the configuration of the second standard sample are attached.
  • the second standard sample includes a container 302 and a barrier container 402 containing the container 302, which is similar to the container 30 of the liquid-filled combination container 10L to be tested and the barrier container 40 containing the container 30.
  • the internal oxygen concentration of the second standard sample container 302 is lower than the internal oxygen concentration of the first standard sample container 301, and the internal oxygen concentration is specified.
  • the second standard sample container 302 has an internal oxygen concentration lower than that of the air and a specified internal oxygen concentration.
  • a specific example of a method of preparing a second standard sample having a container 302 whose internal oxygen concentration is specified will be described.
  • a specific example of a method of preparing a second standard sample having a container 302 with an internal oxygen concentration of 0% will be described.
  • Nitrogen gas is, for example, the standard gas of the US National Institute of Standards and Technology (NIST).
  • NIST National Institute of Standards and Technology
  • the container 302 for the second standard sample may or may not contain the same liquid L2 as the liquid L contained in the container 31 of the container 30 of the liquid combination container 10L in the container 312. good too.
  • the container 302 for the second standard sample contains the liquid L2 in the container 312, the head space HS2 of the container 302 may contain air.
  • the container 302 for the second standard sample does not contain the liquid L2 in the container 312, the entire inside of the container 302 may contain air.
  • the second standard sample is irradiated with laser light or LED light so as to pass through the interior of the container 302, and the attenuation rate of the laser light or LED light is measured.
  • the attenuation rate is measured using the same light source 951 and measurement device 952 as those used in the attenuation rate measurement step.
  • the wavelength of the laser light or LED light irradiated to the second standard sample in the second standard sample measurement step is the same as the wavelength of the laser light or LED light irradiated to the liquid-filled combination container 10L in the attenuation rate measurement step.
  • the second standard sample may be irradiated with laser light or LED light so as to pass through a portion apart from the contact area 31a2 of the housing portion 312 of the container 302 .
  • the second standard sample measurement step it is possible to measure the attenuation rate when the oxygen concentration in the container 302 is a specific value lower than the oxygen concentration in the air.
  • the second standard sample in which the oxygen concentration inside the container 302 is specified as 0% which is prepared by the specific example of the method for preparing the second standard sample described above, the oxygen concentration inside the container 302 is is 0%, the attenuation rate can be measured.
  • the oxygen concentration in the container 30 is measured based on the attenuation rate measured in the attenuation rate measurement process.
  • the attenuation rate measured in the attenuation rate measurement process is used to determine the container 30 of the liquid-filled combination container 10L. including the step of calculating the oxygen concentration in the
  • the relationship between the attenuation rate measured in the first standard sample measuring process and the oxygen concentration inside the container 301 in the first standard sample is used.
  • the relationship between the attenuation rate measured in the second standard sample measuring process and the oxygen concentration inside the container 302 in the second standard sample is used.
  • oxygen concentration Y (%) is a linear function of the attenuation rate X (%)
  • oxygen A linear function expression representing the relationship between the concentration Y (%) and the attenuation rate X (%) is obtained.
  • Equation (1) the equation of the linear function representing the relationship between the oxygen concentration Y (%) and the attenuation rate X (%) can be represented by Equation (1) below.
  • Equation (2) the equation of the linear function representing the relationship between the oxygen concentration Y (%) and the attenuation rate X (%) can be represented by Equation (2) below.
  • the liquid-filled combination container 10L container The oxygen concentration (%) in 30 can be calculated.
  • the first standard sample is not limited to the one containing air inside the container 301 described above.
  • a sample comprising a container 301 whose internal oxygen concentration is specified and a barrier container 401 containing the container 301 can be used.
  • the second standard sample is not limited to the one in which the inside of the container 302 described above is degassed.
  • a container 302 whose internal oxygen concentration is lower than the internal oxygen concentration of the first standard sample container 301 and whose internal oxygen concentration is specified, and a barrier container 402 containing the container 302. can be used.
  • the attenuation rate is measured in three or more standard samples including the first standard sample and the second standard sample, and based on the relationship between the attenuation rate and the oxygen concentration of the three or more standard samples, the liquid-filled combination container 10L , the oxygen concentration in the container 30 may be calculated.
  • the method of specifying the oxygen concentration of standard samples including the first standard sample and the second standard sample is not limited to the above example.
  • the oxygen concentration of the standard sample may be specified using the inspection method of the first embodiment described above. That is, the oxygen concentration in the standard sample container may be specified by providing a fluorescent material on the inner surface of the standard sample container, irradiating the fluorescent material with light, and measuring the fluorescence time or fluorescence intensity of the fluorescent material. . Further, when irradiating laser light or LED light so as to pass through the interior of the container 302 to specify the oxygen concentration of the standard sample including the first standard sample and the second standard sample, the oxygen concentration is determined by the following method. may be specified.
  • a numerical value that changes according to the attenuation rate may be measured, and the oxygen concentration in the container 30 may be measured based on the numerical value.
  • a numerical value proportional to the attenuation rate may be measured, and the oxygen concentration within the container 30 may be measured based on the numerical value.
  • the oxygen concentration may be measured by combining measuring the oxygen concentration based on the attenuation rate of light intensity and measuring the oxygen concentration based on a numerical value that changes according to the attenuation rate. . Thereby, the oxygen concentration can be measured with higher accuracy.
  • the rate of change of light may be measured, including the rate of decay of light intensity, and oxygen concentration may be determined based on the rate of change of light.
  • the change in amplitude or the change in wavelength of light may be measured, and the change in amplitude or the change in wavelength of light may be used to measure the oxygen concentration.
  • laser light or LED light having a wavelength that is attenuated according to the oxygen concentration in the optical path LA is transmitted through a portion away from the contact area 31a of the housing portion 31 of the container 30. and an attenuation rate measuring step of irradiating the liquid-filled combination container 10L and measuring the attenuation rate of laser light or LED light.
  • Measuring the attenuation rate in the attenuation rate measurement step includes measuring a numerical value that changes according to the attenuation rate, for example, a numerical value that is proportional to the attenuation rate.
  • the attenuation rate measuring step may measure the rate of change of the light, including the rate of attenuation of the intensity of the light.
  • the attenuation factor measurement step may measure changes in amplitude or wavelength of light. It also includes a measuring step of measuring the oxygen concentration in the container 30 based on the attenuation rate measured in the attenuation rate measuring step. Further, in measuring the oxygen concentration in the container 30 based on the attenuation rate in the measurement step, by measuring the oxygen concentration in the container 30 based on a numerical value that changes according to the attenuation rate, it is possible to substantially attenuate It includes measuring the oxygen concentration in the container 30 based on the rate.
  • measuring the oxygen concentration in container 30 based on the decay rate in the measurement step includes measuring the oxygen concentration in container 30 based on a numerical value proportional to the decay rate. Furthermore, in the measuring step, measuring the oxygen concentration based on the attenuation rate of light intensity and measuring the oxygen concentration based on a numerical value that changes according to the attenuation rate are combined to determine the oxygen concentration. may be measured. Additionally, the measuring step may measure oxygen concentration based on the rate of change of light. As an example, in the measuring step, the oxygen concentration may be measured using changes in the amplitude or wavelength of the light. Thereby, the oxygen concentration in the container 30 can be measured and inspected without opening the container 30 .
  • the barrier container 40 is in contact with the outer surface 30b at the first position 35a and the second position 35b away from the contact area 31a of the container 31 of the container 30.
  • the liquid-filled combination container 10L is irradiated with laser light or LED light so as to pass through the first position 35a and the second position 35b of the container 30 . Therefore, the optical path LA does not pass through the space inside the barrier container 40 but outside the container 30 (also referred to as the barrier container space 49). This eliminates the effect of oxygen concentration in the barrier container space 49 on the measured decay rate.
  • the influence of the oxygen concentration in the barrier container space 49 on the numerical value that varies according to the attenuation rate for example, the numerical value that is proportional to the attenuation rate, measured in the attenuation rate measurement step can be eliminated.
  • the effect of the oxygen concentration in the barrier container space 49 on the rate of change of light measured in the attenuation rate measurement process can be eliminated.
  • the effect of the oxygen concentration in the barrier container space 49 on changes in amplitude and wavelength of light measured in the attenuation rate measurement process can be eliminated.
  • the positional relationship between the container 30 and the barrier container 40 is determined by the barrier container 40 being in contact with the outer surface 30b of the container 30 .
  • the barrier container 40 is in contact with the outer surface 30b of the container 30, so that the container 30 at the time of measurement and the barrier container 40 can be aligned.
  • the positional relationship between the container 30 and the barrier container 40 at the time of measurement can be aligned.
  • the conditions for measuring the attenuation rate such as the length of the optical path LA of the laser light or the LED light, can be aligned, and the measurement accuracy of the oxygen concentration measured based on the attenuation rate can be improved.
  • the conditions for measuring a numerical value that changes according to the attenuation rate for example, a numerical value that is proportional to the attenuation rate
  • the conditions for measuring the rate of change of light can be arranged.
  • the conditions for measuring changes in amplitude and wavelength of light can be adjusted.
  • the inspection method of the second embodiment further comprises a step of bringing the barrier container 40 into contact with the outer surface 30b of the container 30 at the first position 35a and the second position 35b.
  • the liquid-filled combination container 10L can be irradiated with laser light or LED light while the barrier container 40 is in contact with the outer surface 30b of the container 30 at the first position 35a and the second position 35b.
  • the wavelength of laser light or LED light includes a wavelength of 760 nm.
  • Laser light or LED light with a wavelength of 760 nm is attenuated according to the oxygen concentration in the optical path LA, and is less attenuated according to other factors, such as the concentration of substances other than oxygen. Therefore, by including a wavelength of 760 nm in the wavelength of the irradiated laser light or LED light, it is possible to improve the measurement accuracy of the oxygen concentration in the measurement process.
  • the inspection method of the second embodiment includes a first standard sample measurement step of irradiating the first standard sample with laser light or LED light to measure the attenuation rate; and a second standard sample measurement step of irradiating light and measuring the attenuation rate.
  • the oxygen concentration in the container 30 of the liquid-filled combination container 10L can be measured based on the relationship between the attenuation rate and the oxygen concentration in the first standard sample and the relationship between the attenuation rate and the oxygen concentration in the second standard sample.
  • the barrier property to the container 30 when the liquid-filled combination container 10L is irradiated with laser light or LED light in the attenuation rate measurement step The first standard sample barrier container 401, the light source 951, and the measuring device 952 are arranged with respect to the first standard sample container 301 in the same manner as the container 40, the light source 951, and the measuring device 952. , the first standard sample may be irradiated with laser light or LED light.
  • the arrangement of the barrier container 40, the light source 951, and the measuring device 952 with respect to the container 30 when the liquid-filled combination container 10L is irradiated with laser light or LED light in the attenuation rate measurement step is arranged with respect to the second standard sample container 302, and the first standard sample is irradiated with laser light or LED light.
  • the conditions for measuring the attenuation rate such as the length of the optical path LA of the laser light or the LED light, can be matched in the attenuation rate measurement process, the first standard sample measurement process, and the second standard sample measurement process.
  • the container 30 is transparent at least at the first position 35a and the second position 35b.
  • the barrier container 40 is transparent at least at the first position 35a and the second position 35b in contact with the outer surface 30b. This can reduce the influence of the attenuation of the laser light or LED light when it passes through the container 30 and the barrier container 40 on the measured attenuation rate.
  • the oxygen reactant 20 of the second embodiment is spaced apart from the straight line connecting the first position 35a and the second position 35b. Therefore, by setting the straight line connecting the first position 35 a and the second position 35 b as the optical path LA, the laser light or the LED light can be irradiated so as to pass through the container 30 . As a result, the oxygen concentration in the container 30 can be measured and inspected by the inspection method described above without opening the container 30 . Also, the oxygen concentration in the container 30 can be measured and inspected without opening the barrier container 40 .
  • the oxygen reactant 20 is fixed to at least one of the outer surface 30 b of the container 30 and the inner surface of the barrier container 40 . This can prevent the oxygen reactant 20 from moving to a position that prevents the laser light or LED light from transmitting through the first position 35 a and the second position 35 b of the container 30 .
  • the laser light or the LED light can be applied to the oxygen reactant. It can be illuminated through container 30 without being blocked by 20 .
  • the oxygen-reactive agent 20 can be used as a marker for identifying suitable positions for irradiating the container 30 with laser light or LED light.
  • An example of a method for specifying a position to irradiate the container 30 with laser light or LED light using the oxygen reactive agent 20 as a marker will be described.
  • the positional relationship between the position of the oxygen reactant 20 with respect to the container 30 and the position suitable for irradiating the container 30 with laser light or LED light is specified.
  • the position of the oxygen reactive agent 20 is specified by image detection by a camera or the like.
  • the container A suitable position for irradiating the container 30 with laser light or LED light is specified. This makes it possible to specify a suitable position for irradiating the container 30 with laser light or LED light.
  • the oxygen-reactive agent 20 can be used as a marker for identifying a suitable position for irradiating the container 30 with light that causes the fluorescent material 27 to fluoresce.
  • the oxygen reactant 20 is located on the second surface 34 f side of the plug 34 .
  • the barrier container 40 is in contact with the outer surface 30b of the container 30 over the entire circumference of the container 30 including the first position 35a and the second position 35b. Therefore, in the barrier container 40, a first space S1 located above the first position 35a and the second position 35b and a second space S1 located below the first position 35a and the second position 35b. Movement of oxygen-containing gas is impeded between space S2.
  • the oxygen reactant 20 is arranged in the first space S1 by locating the oxygen reactant 20 on the second surface 34f side of the plug 34 .
  • the oxygen reactant 20 is applied to at least one of the outer surface 30b of the container 30 and the inner surface of the barrier container 40. They have the common feature of being fixed.
  • the above feature prevents the oxygen-reactive agent 20 from moving to a position that prevents the irradiation of the fluorescent material 27 with the light that causes the fluorescent material 27 to fluoresce. be.
  • the oxygen reactant 20 is placed at a position that prevents the laser light or the LED light from transmitting through the first position 35 a and the second position 35 b of the container 30 due to the above features. Movement is suppressed.
  • the oxygen reactant 20 can be used for measuring the oxygen concentration. A common effect is obtained in that the container 30 is prevented from moving to a position that blocks the irradiation of the light with which the container 30 is irradiated.
  • the barrier container 40 contacts the outer surface 30b of the fluorescent material installation position 39 of the container 30.
  • the barrier container 40 contacts the outer surface 30b of the fluorescent material installation position 39 of the container 30, the positional relationship between the fluorescent material installation position 39 of the container 30 and the barrier container 40 can be easily determined. Therefore, it becomes easy to determine the optical path of the light emitted from the illumination unit 81 and transmitted through the barrier container 40 and the fluorescent material installation position 39 of the container 30 to cause the fluorescent material 27 to fluoresce.
  • the positional relationship between the fluorescent material installation position 39 of the container 30 and the barrier container 40 at the time of measurement is aligned.
  • the positional relationship between the fluorescent material installation position 39 of the container 30 and the barrier container 40 at the time of measurement can be aligned.
  • the optical paths of the light emitted from the illumination unit 81 and transmitted through the barrier container 40 and the fluorescent material installation position 39 of the container 30 to cause the fluorescent material 27 to fluoresce can be aligned.
  • the barrier container 40 contacts the outer surface 30b of the container 30 at the first position 35a and the second position 35b. Since the barrier container 40 contacts the outer surface 30b of the container 30 at the first position 35a and the second position 35b, the positional relationship between the first position 35a and the second position 35b of the container 30 and the barrier container 40 can be easily determined. Become. Therefore, it becomes easier to determine the optical path LA of the laser light or LED light emitted from the light source 951 and transmitted through the barrier container 40 and the first position 35 a and the second position 35 b of the container 30 to reach the measuring device 952 .
  • the first position 35a and the second position 35b of the container 30 at the time of measurement and the barrier container 40 You can align the positional relationship of Similarly, when measuring the oxygen concentration in the container 30 of a plurality of liquid-filled combination containers 10L, the positional relationship between the first position 35a and the second position 35b of the container 30 at the time of measurement and the barrier container 40 is aligned. be done. As a result, optical paths LA of laser light or LED light emitted from the light source 951 and transmitted through the barrier container 40 and the first position 35a and the second position 35b of the container 30 to reach the measuring device 952 can be aligned.
  • the liquid-filled combination container 10L of the first embodiment and the liquid-filled combination container 10L of the second embodiment have a common structure in which the barrier container 40 contacts at least part of the outer surface 30b of the container 30. It has characteristics. Further, according to the liquid-filled combination container 10L of the first embodiment and the liquid-filled combination container 10L of the second embodiment, due to the features described above, the container 30 is irradiated with light for measuring the oxygen concentration. It is possible to obtain a common effect that the optical path of is easily determined.
  • the oxygen reactive agent 20 may be used to adjust the vertical position of the container 30 within the barrier container 40 .
  • oxygen reactant 20 is placed below container 30, which is upright.
  • the container 30 can be positioned higher than if the oxygen reactant 20 were not positioned below the container 30 .
  • the positional relationship between the container 30 and the devices used for measuring the oxygen concentration, such as the light source 951 and the measuring device 952 can be adjusted.
  • the oxygen reactant 20 may be placed above the upright container 30 .
  • the oxygen-reactive agent 20 can be easily used as a marker for specifying a suitable position for irradiating the container 30 with laser light or LED light.
  • the oxygen-reactive agent 20 can be easily used as a marker for identifying a suitable position for irradiating the container 30 with light that causes the fluorescent material 27 to fluoresce.
  • the pressing member for pressing the container 30 is brought close to the liquid-filled combination container 10L from above to deform the flexible barrier container 40 to hold the container 30 between the pressing member and the mounting surface.
  • the oxygen concentration in the container 30 may be measured.
  • the pressing member since the size of the established container 30 in the vertical direction is small, the pressing member may not come into contact with the container 30 and may not be able to hold the container 30 between the pressing member and the mounting surface.
  • the oxygen reactant 20 may be arranged above the upright container 30 . This brings the pressing member into contact with the oxygen-reactive agent 20 and transmits force from the pressing member to the container 30 via the oxygen-reactive agent 20 . Therefore, the container 30 can be held together with the oxygen reactant 20 between the pressing member and the mounting surface.
  • the barrier container 40 may be designed such that when the container 30 is placed in the barrier container 40, the barrier container 40 naturally contacts the outer surface 30b of the container 30 at the first location 35a and the second location 35b.
  • 19A and 19B are views showing a liquid-filled combination container 10L of Modification 4.
  • FIG. FIG. 19 corresponds to a cross-sectional view of the liquid-filled combination container 10L with the barrier container 40 in contact with the outer surface 30b of the container 30 at the first position 35a and the second position 35b.
  • the liquid-filled combination container 10L shown in FIG. 19 is similar to the liquid-filled combination container 10L shown in FIG. Similar to the liquid-filled combination container 10L shown in FIG. 15, the container 30 is a vial having a container body 32 which is a glass bottle and a stopper .
  • the container 30 has a substantially cylindrical outer shape.
  • the barrier container 40 has a substantially cylindrical outer shape. 19, the outer diameter w1 of the container 30 matches the inner diameter w2 of the barrier container 40. As shown in FIG. Therefore, when the container 30 is accommodated in the barrier container 40, the barrier container 40 naturally contacts the outer surface 30b of the container 30 at the first position 35a and the second position 35b.
  • the barrier container 40 shown in FIG. 19 can stably maintain a state in which the barrier container 40 is in contact with the outer surface 30b of the container 30 at the first position 35a and the second position 35b.
  • the barrier container 40 is in contact with the outer surface 30b at the first position 35a and the second position 35b of the container 30, so that the barrier container relative to the measured attenuation rate
  • the effect of oxygen concentration in space 49 can be eliminated.
  • the positional relationship between the container 30 and the barrier container 40 can be determined.
  • the first position 35a and the second position 35b through which the laser light or the LED light is transmitted are not particularly limited as long as the oxygen reactive agent 20 is separated from the straight line connecting the positions.
  • the barrier container 40 does not have to contact the outer surface 30b of the container 30 at the first position 35a and the second position 35b.
  • the first position 35a and the second position 35b of the container 30 may be positioned so that the barrier container 40 does not contact the outer surface 30b.
  • the liquid-filled combination container 10L may be irradiated with laser light or LED light while the barrier container 40 is not in contact with the outer surface 30b of the container 30 .
  • the liquid-filled combination container 10L may be irradiated with laser light or LED light so as to pass through a position of the container 30 that is not in contact with the barrier container 40 .
  • the following is performed. to perform the inspection method.
  • the container 30, the barrier container 40, the light source 951, and the measuring device 952 are aligned in position, and the liquid-filled combination container 10L is irradiated with laser light or LED light.
  • the conditions for measuring the attenuation rate such as the length of the optical path LA of the laser light or the LED light, can be aligned, and the measurement accuracy of the oxygen concentration measured based on the attenuation rate can be improved.
  • FIG. 20 is a diagram showing an example of how the liquid-filled combination container 10L is irradiated with laser light or LED light in the inspection method for the liquid-filled combination container 10L of Modification 5.
  • FIG. 21 is a diagram showing another example of how the liquid-filled combination container 10L is irradiated with laser light or LED light in the inspection method for the liquid-filled combination container 10L of Modification 5.
  • FIG. 10 In the example shown in FIGS. 20 and 21 , the container 30 is fixed to the barrier container 40 by a second fixing member 922 different from the container 30 and the barrier container 40 .
  • the container 30 is fixed to the barrier container 40 at least while the liquid-filled combination container 10L is irradiated with laser light or LED light.
  • the container 30 may be fixed to the barrier container 40 by being adhered to the inner surface of the barrier container 40 with an adhesive or the like.
  • the liquid-filled combination container 10L in which the positional relationship between the container 30 and the barrier container 40 is determined by the contact between the outer surface 30b of the container 30 and the inner surface of the barrier container 40 is Included in liquid-filled combination container 10L fixed to barrier container 40 .
  • the container 30 , and the barrier container 40 can be aligned to measure the oxygen concentration.
  • the barrier container 40 of the liquid-filled combination container 10L shown in FIGS. 20 and 21 is similar to the barrier container 40 shown in FIG.
  • the liquid-filled container 30L of the liquid-filled combination container 10L shown in FIGS. 20 and 21 is similar to the liquid-filled container 30L shown in FIGS.
  • the liquid-filled combination container 10L comprises one oxygen reactant 20.
  • oxygen reactive agent 20 is oxygen scavenger 21 .
  • the oxygen reactant 20 is secured to the outer surface 30b of the container 30.
  • oxygen reactant 20 is secured to stopper 34 of container 30 .
  • the position of the barrier container 40 relative to the container 30 is fixed by a second fixing member 922 different from the container 30 and the barrier container 40 . Thereby, the positional relationship between the container 30 and the barrier container 40 can be aligned.
  • the second fixing member 922 is a tray-like container.
  • the second fixing member 922 shown in FIG. 20 has a bottom portion 922a, a side portion 922b, and a flange portion 922c.
  • the side surface portion 922b is connected to the periphery of the bottom surface portion 922a at a first end 922d.
  • the side portion 922b connects to the flange portion 922c at a second end 922e located opposite the first end 922d.
  • the material of the second fixing member 922 is similar to that of the container 30 or the barrier container 40, for example.
  • the second fixing member 922 is sandwiched between the outer surface 30b of the container 30 and the inner surface of the barrier container 40 to fix the position of the barrier container 40 with respect to the container 30.
  • the second fixing member 922 contacts the outer surface 30b of the container 30 at the bottom portion 922a and the side portion 922b, and contacts the inner surface of the barrier container 40 at the flange portion 922c.
  • the container 30 is supported by the intermediate container 50 and left stationary.
  • container 30 is upright within barrier container 40 .
  • the entirety of the second fixing member 922 (intermediate container 50) is positioned below the first position 35a and the second position 35b of the upright container 30 within the barrier container 40. positioned.
  • the oxygen reactant 20 also serves as the second fixing member 922. That is, the position of the barrier container 40 with respect to the container 30 is fixed by sandwiching the oxygen reactive agent 20 between the outer surface 30b of the container 30 and the inner surface of the barrier container 40 .
  • the oxygen reactant 20 is an oxygen scavenger 21 .
  • the oxygen reactant 20 is sandwiched between the outer surface 30b of the container 30 and the inner surface of the barrier container 40. In the example shown in FIG. This suppresses the horizontal movement of the oxygen reactant 20 .
  • the container 30 of the liquid-filled combination container 10L is in a stationary state, particularly in an upright state. In this state, vertical movement of the oxygen reactant 20 is suppressed by the action of gravity. Thereby, it is fixed to the outer surface 30 b of the container 30 and the inner surface of the barrier container 40 .
  • portions of the container 30 and the barrier container 40 that transmit laser light or LED light are transparent. This can reduce the influence of the attenuation of the laser light or LED light when it passes through the container 30 and the barrier container 40 on the measured attenuation rate.
  • the second fixing member 922 fixes the position of the barrier container 401 for the first standard sample with respect to the container 301 for the first standard sample, and the first standard sample is measured.
  • the sample may be irradiated with laser light or LED light.
  • the second standard sample measurement step is performed in Modified Example 5
  • the position of the second standard sample barrier container 402 with respect to the second standard sample container 302 is fixed by the second fixing member 922, and the second standard sample is measured.
  • the sample may be irradiated with laser light or LED light.
  • the attenuation rate measurement conditions such as the length of the optical path LA of the laser light or the LED light, can be aligned in the attenuation rate measurement process, the first standard sample measurement process, and the second standard sample measurement process.
  • FIG. 22A is a diagram showing an example of how the liquid-filled combination container 10L is irradiated with laser light or LED light in the inspection method for the liquid-filled combination container 10L of Modification 6.
  • FIG. The liquid-containing combination container 10L shown in FIG. 22A is similar to the barrier container 40 shown in FIG. 20, except that the intermediate container 50 has a different shape.
  • the intermediate container 50 In the example shown in FIG. 22A, a portion of the intermediate container 50 is located above the first position 35a and the second position 35b of the upright container 30 within the barrier container 40. In the example shown in FIG. Therefore, the intermediate container 50 covers the first position 35 a and the second position 35 b of the container 30 from the outer periphery of the container 30 . As shown in FIG. 22A, the intermediate container 50 has an intermediate container light-transmitting portion 51 that intersects a straight line connecting the first position 35a and the second position 35b of the container 30 and transmits light. In the example shown in FIG. 22A, the straight line indicating the optical path LA corresponds to the straight line connecting the first position 35a and the second position 35b. In the example shown in FIG.
  • the intermediate container 50 has a pair of intermediate container light-transmitting portions 51 .
  • the shape of the intermediate container light-transmitting portion 51 is not particularly limited as long as it allows light to pass through.
  • the intermediate container light-transmitting portion 51 is made of a light-transmitting material.
  • the intermediate container light transmission part 51 may be a through hole provided in the wall surface of the intermediate container 50 .
  • the intermediate container 50 has the intermediate container light transmitting portion 51, even when the intermediate container 50 covers the first position 35a and the second position 35b of the container 30, the first position 35a and the second position 35b of the container 30 are covered. Laser light or LED light can be irradiated so as to pass through the second position 35b.
  • FIG. 22B is a diagram showing an example of how the liquid-filled combination container 10L is irradiated with laser light or LED light in the inspection method for the liquid-filled combination container 10L of Modification 7.
  • FIG. Liquid-filled combination container 10L shown in FIG. 17 is similar to liquid-filled combination container 10L.
  • the barrier container 40 is not fixed with respect to the container 30. Also in the liquid-filled combination container 10L shown in FIG. The oxygen concentration in container 30 can be measured. In particular, the barrier container 40 is fixed relative to the container 30 if the effect of oxygen located outside the container 30 on the measured decay rate is sufficiently small compared to the effect of oxygen located within the container 30. Even if it is not, the oxygen concentration measurement accuracy can be sufficiently improved. When the effect of oxygen located outside the container 30 on the measured decay rate is sufficiently small compared to the effect of oxygen located inside the container 30, for example, the oxygen concentration outside the container 30 is This is the case where it is sufficiently small compared to the oxygen concentration.
  • the optical path LA passes through the inside of the container 30 and also through the barrier container space 49 and the outside of the barrier container 40 .
  • the measured decay rate is affected by oxygen within container 30 and by oxygen within barrier container space 49 and outside barrier container 40 .
  • the barrier container 40 will be close to the container 30 Even if it is not fixed with respect to, the measurement accuracy of the oxygen concentration can be sufficiently high.
  • the feature that the barrier container 40 is not fixed to the container 30 may be combined with the liquid-filled combination container 10L comprising the fluorescent material 27 of the first embodiment.
  • the fluorescent material 27 by irradiating the fluorescent material 27 with light that causes the fluorescent material 27 to fluoresce and measuring the fluorescence time or fluorescence intensity of the fluorescent material 27, can measure the oxygen concentration of
  • the effect of oxygen located outside the container 30 on the fluorescence time or fluorescence intensity of the fluorescent material 27 to be measured is sufficiently small compared to the effect of oxygen located inside the container 30, the measurement accuracy of the oxygen concentration can be made high enough.
  • the liquid-filled combination container 10L may further include an outer container 55 that houses the barrier container 40 .
  • FIG. 22C is a diagram showing an example of how the liquid-filled combination container 10L is irradiated with laser light or LED light in the inspection method for the liquid-filled combination container 10L of Modification 8.
  • FIG. The liquid-filled combination container 10L shown in FIG. 22C is similar to the liquid-filled combination container 10L shown in FIG.
  • Outer container 55 may support container 30 and barrier container 40 . The container 30 may stand still by being supported by the outer container 55 .
  • the outer container 55 has a light transmitting portion 56 that intersects a straight line connecting the first position 35a and the second position 35b of the container 30 and transmits light.
  • the straight line indicating the optical path LA corresponds to the straight line connecting the first position 35a and the second position 35b.
  • the outer container 55 has a pair of light transmitting portions 56 .
  • the outer container 55 has an outer container main body 57 and a light transmitting portion 56 provided on the outer container main body 57 .
  • the outer container main body 57 does not have optical transparency.
  • the material of the outer container main body 57 is paper, for example.
  • the outer container main body 57 is, for example, a box made of paper.
  • the form of the light transmission part 56 is not particularly limited as long as it allows light to pass through.
  • the light transmitting portion 56 is made of a material having light transmittance.
  • the light transmitting portion 56 may be a through hole provided in the outer container main body 57 .
  • the light transmitting portion 56 is a through hole, when a straight line connecting the first position 35a and the second position 35b of the container 30 passes through the through hole, the light transmitting portion 56 is positioned between the first position 35a and the second position 35b. It is assumed that it intersects the straight line connecting the position 35b.
  • the outer container 55 has the light transmitting portion 56, even when the barrier container 40 is provided with the outer container 55, the laser light or LED light can be applied.
  • the form of the barrier container 40 is not limited to the form described above.
  • 23A is a perspective view showing an example of a barrier container 40 of Modification 9.
  • FIG. 23A is closed by bonding films to form a seal portion 43, similar to the barrier container 40 shown in FIG.
  • the form of the barrier container 40 shown in FIG. 23A is the same as the barrier container 40 shown in FIG. 4 except for the points described later.
  • the barrier container 40 shown in FIG. 23A has a seal portion through-hole 41 f provided in the seal portion 43 .
  • the side opposite to the bottom side of the barrier container 40 shown in FIG. 23A is referred to as the upper end side of the barrier container 40 .
  • the seal portion through-hole 41 f is provided in a portion of the seal portion 43 located on the upper end side of the barrier container 40 .
  • the liquid-filled combination container 10L can be transported using the seal portion through-hole 41f.
  • the liquid-filled combination container 10L can be hung from the hook-shaped member by passing the tip of the hook-shaped member through the seal portion through-hole 41f.
  • the liquid-filled combination container 10L can be transported by moving the hook-shaped member while the liquid-filled combination container 10L is hung from the hook-shaped member.
  • the barrier container 40 may have a plurality of seal portion through-holes 41f. In this case, when hanging the liquid-filled combination container 10L using the sealing portion through-holes 41f, the tip of each of the plurality of hook-shaped members may be passed through each of the plurality of sealing portion through-holes 41f.
  • the barrier container 40 has two seal through-holes 41f, a first seal through-hole 41f1 and a second seal through-hole 41f2.
  • the first hook-shaped member may be passed through the first seal portion through-hole 41f1
  • the second hook-shaped member may be passed through the second seal portion through-hole 41f2.
  • the following effects are obtained by measuring the oxygen concentration in the container 30 in a state in which the liquid-filled combination container 10L is suspended by passing the tip of a hook-shaped member through the seal portion through-hole 41f of the barrier container 40. be done.
  • the action of gravity determines the position of container 30 within barrier container 40 . Therefore, when measuring the oxygen concentration in the container 30 of the same liquid-filled combination container 10L at a plurality of times, the positions of the containers 30 in the barrier container 40 at the time of measurement can be aligned. In the case of measuring the oxygen concentrations in the containers 30 of a plurality of liquid-filled combination containers 10L, similarly, the positions of the containers 30 in the barrier container 40 at the time of measurement can be aligned.
  • the measurement conditions for measuring the oxygen concentration in the container 30 can be uniformed, and the measurement accuracy of the oxygen concentration can be improved.
  • the liquid-filled combination container 10L is stably supported by the hook-shaped members by passing the tip of each of the plurality of hook-shaped members through each of the plurality of seal portion through-holes 41f. Therefore, the position of the container 30 in the barrier container 40 is more stably determined in a state in which the liquid-filled combination container 10L is suspended. Thereby, the measurement accuracy of the oxygen concentration can be further improved.
  • the barrier container 40 may not have the seal portion through-hole 41f.
  • the barrier container 40 shown in FIG. 4 and the barrier container 40 shown in FIG. 23A can be hung by the first member and the second member by sandwiching the seal portion 43 between the first member and the second member.
  • the position of the container 30 within the barrier container 40 is determined by the action of gravity. This can improve the measurement accuracy of the oxygen concentration.
  • the container 30 may be left stationary by hanging the liquid-filled combination container 10L. That is, the position of the container 30 in the barrier container 40 may be determined by suspending the liquid-filled combination container 10L, and the liquid level of the liquid L contained in the container 31 may be stabilized.
  • the oxygen reactant 20 is fixed to at least one of the outer surface 30b of the container 30 and the inner surface of the barrier container 40.
  • the liquid-filled combination container 10L is not limited to this.
  • the oxygen reactant 20 may not be fixed to either the outer surface 30b of the container 30 or the inner surface of the barrier container 40.
  • FIG. 23B is a perspective view showing an example of a liquid-filled combination container 10L of Modification 10.
  • the barrier container 40 of the liquid-filled combination container 10L shown in FIG. 23B is similar to the barrier container 40 shown in FIG. 23A, except for the points described below.
  • the oxygen reactive agent 20 is not fixed to the inner surface of the barrier container 40 shown in FIG. 23B.
  • An oxygen reactant containing portion 49a containing the oxygen reactant 20 is defined in a portion of the barrier container 40 shown in FIG. 23B.
  • the oxygen reactant containing portion 49 a is defined in a portion of the barrier container space 49 .
  • the liquid-filled combination container 10L shown in FIG. 23B further comprises a container 30 containing liquid L and an oxygen reactant 20 .
  • the liquid-filled combination container 10L shown in FIG. 23B can measure the oxygen concentration in the container 30 by the following method. Suitable positions for container 30 are defined as first position 35a and second position 35b. Next, the liquid-filled combination container 10L is irradiated with laser light or LED light so as to pass through the first position 35a and the second position 35b, and the attenuation rate of the laser light or LED light is measured. Then, the oxygen concentration in the container 30 is measured from the measured attenuation rate.
  • the storage portion of the barrier container 40 is divided into a plurality of portions including an oxygen reactant storage portion 49a and a container storage portion 49b that stores the container 30 containing the liquid L.
  • the storage portion of the barrier container 40 shown in FIG. 23B is divided into two portions, an oxygen reactant storage portion 49a and a container storage portion 49b.
  • oxygen can move between the oxygen reactant containing portion 49a and the container containing portion 49b. divided so that you cannot move between them.
  • the split seal portion 47 splits the accommodating portion of the barrier container 40 .
  • the containing portion of the barrier container 40 is divided by a split seal portion 47 into an oxygen reactant containing portion 49a and a container containing portion 49b.
  • the split seal portion 47 is provided with a gap 47a through which the first main film 41a and the second main film 41b are not joined.
  • the width of the gap is less than the minimum width of container 30 and oxygen reactant 20 . Oxygen can move between the oxygen reactant containing portion 49a and the container containing portion 49b through the gap 47a of the split seal portion 47.
  • FIG. 23B the containing portion of the barrier container 40 is divided by a split seal portion 47 into an oxygen reactant containing portion 49a and a container containing portion 49b.
  • the split seal portion 47 is provided with a gap 47a through which the first main film 41a and the second main film 41b are not joined.
  • the split seal portion 47 prevents the container 30 housed in the container housing portion 49b from moving to the oxygen reactant housing portion 49a.
  • the split seal portion 47 prevents the oxygen reactant 20 contained in the oxygen reactant containing portion 49a from moving to the container containing portion 49b.
  • the method of dividing the storage portion of the barrier container 40 into a plurality of portions including the oxygen reactant storage portion 49a is not limited to the method of providing the split seal portion 47.
  • a plurality of through-holes passing through the first main film 41a and the second main film 41b are formed, and the first main film 41a and the second main film 41b around which the through-holes are formed are deformed and meshed. By combining them, the accommodating portion of the barrier container 40 may be divided.
  • the container 30 is in an upright state.
  • the oxygen reactant containing portion 49a is positioned below the container containing portion 49b.
  • the positional relationship between the oxygen reactant storage portion 49a and the container storage portion 49b is not limited to the example shown in FIG. 23B.
  • the oxygen reactant storage portion 49a may be positioned above the container storage portion 49b.
  • the oxygen reactant storage portion 49a and the container storage portion 49b may be horizontally aligned.
  • the oxygen reactant 20 is accommodated in the oxygen reactant accommodating portion 49a, and is arranged at a position spaced apart from the straight line connecting the first position 35a and the second position 35b.
  • the oxygen reactant 20 contained in the oxygen reactant containing portion 49a is not positioned on the straight line connecting the first position 35a and the second position 35b. Therefore, by setting the straight line connecting the first position 35 a and the second position 35 b as the optical path LA, the laser light or the LED light can be irradiated so as to pass through the container 30 .
  • the oxygen reactant 20 can be prevented from moving to a position that prevents the laser light or LED light from passing through the first position 35 a and the second position 35 b of the container 30 .
  • the oxygen reactant 20 is not fixed to the inner surface of the barrier container 40, and an oxygen reactant containing portion 49a for containing the oxygen reactant 20 is defined in a part of the barrier container 40.
  • an oxygen reactant containing portion 49a for containing the oxygen reactant 20 is defined in a part of the barrier container 40.
  • the liquid-filled combination container 10L comprising the fluorescent material 27 of the first embodiment. That is, the oxygen reactant containing portion 49 a containing the oxygen reactant 20 may be defined in a part of the barrier container 40 of the liquid-filled combination container 10 ⁇ /b>L including the fluorescent material 27 .
  • the oxygen reactant 20 is accommodated in the oxygen reactant accommodating portion 49a so that it is arranged at a position where it is not sandwiched between the fluorescent material installation position 39 and the light transmitting position 40b. be. Therefore, the fluorescent material 27 can be irradiated with light from the outside of the barrier container 40 by passing through the fluorescent material installation position 39 and the light transmission position 40b. In such a liquid-filled combination container 10L, the fluorescent material 27 is irradiated with light that causes the fluorescent material 27 to fluoresce, and the fluorescence time or fluorescence intensity of the fluorescent material 27 is measured. The oxygen concentration in the container 30 can be measured based on.
  • the containing portion of the barrier container 40 of the liquid-filled combination container 10L including the fluorescent material 27 is divided so that the container 30 and the oxygen reactant 20 cannot move between the oxygen reactant containing portion 49a and the container containing portion 49b.
  • the following effects can be obtained. It is possible to prevent the oxygen-reactive agent 20 from moving to a position that interferes with irradiation of the fluorescent material 27 with light.
  • Modification 11 In Modification 10 described above, the storage portion of the barrier container 40 is divided so that the container 30 and the oxygen reactant 20 cannot move between the oxygen reactant storage portion 49a and the container storage portion 49b.
  • the combination container 10L has been described. However, the liquid-filled combination container 10L is not limited to this.
  • FIG. 23C is a cross-sectional view showing an example of a liquid-filled combination container 10L of modified example 11.
  • FIG. The liquid-filled combination container 10L shown in FIG. 23C is similar to the liquid-filled combination container 10L shown in FIG. 20, except for the points described below.
  • the intermediate container 50 partitions a part of the barrier container 40 into an oxygen reactant containing portion 49a containing the oxygen reactant 20 .
  • the oxygen reactant 20 is contained in an oxygen reactant containing portion 49 a partitioned by the intermediate container 50 .
  • the container 30 of the liquid-filled combination container 10L shown in FIG. 23C is in a stationary state, particularly in an upright state.
  • the intermediate container 50 of the liquid-filled combination container 10L shown in FIG. 23C further has a storage portion first side surface portion 922f, a storage portion second side surface portion 922g, and a storage portion bottom surface portion 922h.
  • the housing portion first side surface portion 922f is a plate-like portion parallel to the vertical direction.
  • the housing portion first side surface portion 922f is connected at its upper end to the end portion of the flange portion 922c opposite to the end portion connected to the side surface portion 922b.
  • the housing bottom surface portion 922h is a plate-like portion parallel to the horizontal direction.
  • the housing portion second side surface portion 922g is a plate-like portion parallel to the vertical direction.
  • the housing portion second side surface portion 922g is connected at its lower end to the end portion of the housing portion bottom surface portion 922h opposite to the end portion connected to the housing portion first side surface portion 922f.
  • the housing portion first side surface portion 922f, the housing portion second side surface portion 922g, and the housing portion bottom surface portion 922h may be provided over the entire outer periphery of the flange portion 922c, or may be provided on a portion of the outer periphery of the flange portion 922c. may have been
  • the oxygen reactant storage portion 49a is partitioned by the storage portion first side surface portion 922f, the storage portion second side surface portion 922g, and the storage portion bottom surface portion 922h.
  • the oxygen reactant 20 is accommodated in the oxygen reactant accommodating portion 49a by utilizing the action of gravity when the container 30 is in a stationary state, particularly an upright state. be done.
  • the oxygen reactant 20 is accommodated in the oxygen reactant accommodating portion 49a, so that it is arranged at a position away from the straight line connecting the first position 35a and the second position 35b.
  • the intermediate container 50 is provided with a visual recognition permitting device that allows the display portion 26 of the oxygen detecting material 25 to be visually recognized from the outside of the intermediate container 50 . It may have a portion 52 .
  • the visual recognition allowance part 52 is provided in the accommodation part 2nd side surface part 922g.
  • the form of the visual recognition permitting portion 52 is not particularly limited as long as the display portion 26 of the oxygen detecting material 25 contained in the oxygen reactant containing portion 49a can be visually recognized.
  • the visual recognition permission portion 52 is made of a transparent material.
  • the visual recognition allowance part 52 may be a through hole or a notch provided in the wall surface of the intermediate container 50 .
  • the oxygen detecting material 25 is stored with the display portion 26 facing the second side surface portion 922g of the housing portion as shown in FIG. 23C. good too.
  • the oxygen detecting material 25 may be accommodated in the oxygen reactive agent accommodating portion 49a at a position closer to the accommodating portion second side surface portion 922g than the oxygen scavenger 21 is. This makes it possible to easily see the display portion 26 from the outside of the liquid-filled combination container 10L.
  • the feature that the liquid-filled combination container 10L is provided with the intermediate container 50 and the feature that the intermediate container 50 partitions the oxygen reactant storage portion 49a are provided with the fluorescent material 27 of the first embodiment. It may be combined with the liquid-filled combination container 10L. That is, the liquid-filled combination container 10L including the fluorescent material 27 may further include the intermediate container 50, and the intermediate container 50 may define the oxygen reactant storage portion 49a. For example, the liquid-containing combination container 10L shown in FIG. good too.
  • the oxygen concentration in the barrier container 40 of the liquid-filled combination container 10L is measured.
  • the oxygen concentration in the barrier container 40 means the oxygen concentration in the space inside the barrier container 40 and outside the container 30 , that is, the barrier container space 49 described above.
  • FIG. 24 is a diagram illustrating an example of an inspection method according to the third embodiment of the present disclosure.
  • FIG. 25 is a diagram explaining another example of the inspection method according to the third embodiment of the present disclosure.
  • the liquid-filled combination container 10L shown in FIG. 24 is similar to the liquid-filled combination container 10L shown in FIG. It is the same. That is, the liquid-filled combination container 10L shown in FIG. 24 includes the container 30, the barrier container 40, and the fluorescent material 27.
  • the container 30 stores the liquid L in the storage portion 31 and has oxygen permeability.
  • the barrier container 40 accommodates the container 30 and has oxygen barrier properties.
  • the fluorescent material 27 differs in fluorescence time or fluorescence intensity depending on the surrounding oxygen concentration.
  • a position where the fluorescent material 27 is provided on the inner surface of the barrier container 40 is referred to as a barrier container fluorescent material installation position 40c. In other words, the fluorescent material 27 is provided on the inner surface of the barrier container fluorescent material installation position 40 c of the barrier container 40 .
  • the barrier container 40 has optical transparency at least at the barrier container fluorescent material installation position 40c.
  • the liquid-filled combination container 10L shown in FIG. 24 further comprises at least one oxygen reactant 20 capable of reacting with the oxygen within the barrier container 40 .
  • the oxygen reactive agent 20 is fixed to at least one of the outer surface 30 b of the container 30 and the inner surface of the barrier container 40 . As will be described later, in the liquid-filled combination container 10L shown in FIG. can be irradiated.
  • the inspection method for inspecting the oxygen concentration in the barrier container 40 of the liquid-filled combination container 10L shown in FIG. 24 includes a barrier container fluorescence measurement step and a barrier container measurement step.
  • the barrier container fluorescence measurement step the fluorescent material 27 is irradiated with the light that causes the fluorescent material 27 to fluoresce through the barrier container fluorescent material installation position 40 c of the barrier container 40 .
  • the fluorescence time or fluorescence intensity of the fluorescent material 27 is measured.
  • the oxygen concentration in the barrier container 40 is measured based on the fluorescence time or fluorescence intensity of the fluorescent material 27 measured in the barrier container fluorescence measurement step.
  • the oxygen reactant 20 is applied to the outer surface 30b of the container 30 and It does not have to be fixed to any of the inner surfaces of the barrier container 40 .
  • a part of the barrier container 40 may be partitioned with an oxygen reactant containing portion.
  • the oxygen-reacting agent 20 is accommodated in the oxygen-reacting agent-accommodating portion so that it is arranged at a position that does not hinder the irradiation of the fluorescent material 27 with light from the outside of the barrier container 40 .
  • the fluorescent material 27 can be irradiated with the light for irradiating the fluorescent material 27 from the outside of the barrier container 40 .
  • the descriptions of the liquid-filled combination container 10L in the first embodiment, the second embodiment, and the modifications 1 to 11 are that the fluorescent material 27 is provided on the inner surface of the barrier container 40 and the barrier It can also be applied to the liquid-filled combination container 10L in which the oxygen concentration in the container 40 is measured.
  • the descriptions of the oxygen reactant storage portion 49a in Modifications 10 and 11 indicate that the fluorescent material 27 is provided on the inner surface of the barrier container 40 and the oxygen concentration in the barrier container 40 is measured. It can also be applied to the oxygen reactant accommodating portion of the liquid-filled combination container 10L.
  • the description of the inspection method for inspecting the oxygen concentration in the container 30 in the first embodiment, the second embodiment, and the modifications 1 to 11 can be applied to the barrier container 40 shown in FIG. It can also be applied to an inspection method for inspecting the oxygen concentration inside.
  • the descriptions of the fluorescence measurement process in the first embodiment, the second embodiment, and Modifications 1 to 11 can also be applied to the barrier container fluorescence measurement process as long as there is no contradiction.
  • the descriptions of the measurement steps in the first embodiment, the second embodiment, and Modifications 1 to 11, unless contradictory, apply to the inspection method for the liquid-filled combination container 10L shown in FIG. It can also be applied to the barrier property container measurement process.
  • the liquid-filled combination container 10L shown in FIG. 25 is the same as the liquid-filled combination container 10L shown in FIG. is. That is, the liquid-filled combination container 10L shown in FIG. 25 includes the container 30 and the barrier container 40.
  • the container 30 stores the liquid L in the storage portion 31 and has oxygen permeability.
  • the barrier container 40 accommodates the container 30 and has oxygen barrier properties.
  • the barrier container 40 is transparent at least at a barrier container first position 45a and a barrier container second position 45b, which will be described later.
  • the liquid-filled combination container 10L shown in FIG. 25 further comprises at least one oxygen reactant 20 capable of reacting with the oxygen within the barrier container 40 .
  • the oxygen reactant 20 is fixed to at least one of the outer surface 30 b of the container 30 and the inner surface of the barrier container 40 .
  • the barrier container 40 has a barrier container first position 45a and a barrier container second position 45b.
  • Oxygen reactant 20 and container 30 are spaced apart from a straight line connecting barrier container first location 45a and barrier container second location 45b.
  • the straight line indicating the optical path LA corresponds to the straight line connecting the barrier container first position 45a and the barrier container second position 45b.
  • the oxygen reactant 20 and the container 30 are separated from the straight line indicating the optical path LA. In other words, oxygen reactant 20 and container 30 are not located on a straight line connecting barrier container first position 45a and barrier container second position 45b.
  • the barrier container 40 has optical transparency at least at the barrier container first position 45a and the barrier container second position 45b.
  • the barrier container 40 has optical transparency at least at the barrier container first position 45a and the barrier container second position 45b.
  • the inspection method for inspecting the oxygen concentration in the barrier container 40 of the liquid-filled combination container 10L shown in FIG. 25 includes a barrier container attenuation rate measurement step and a barrier container measurement step.
  • the barrier container attenuation rate measuring step laser light or LED light having a wavelength that is attenuated according to the oxygen concentration in the optical path LA is transmitted through the barrier container first position 45a and the barrier container second position 45b. , irradiate the liquid-filled combination container 10L.
  • the liquid-filled combination container 10L is irradiated with laser light or LED light so as to pass through the barrier container space 49 .
  • the attenuation rate of laser light or LED light is measured.
  • the oxygen concentration in the barrier container 40 is measured based on the attenuation rate measured in the barrier container attenuation rate measuring step.
  • the oxygen reactant 20 is It may not be fixed to either the outer surface 30b of the barrier container 30 or the inner surface of the barrier container 40. In this case, a part of the barrier container 40 may be partitioned with an oxygen reactant containing portion.
  • the oxygen reactant 20 is accommodated in the oxygen reactant accommodating portion, and thus is arranged at a position away from the straight line connecting the barrier container first position 45a and the barrier container second position 45b. As a result, laser light or LED light can be irradiated so as to pass through the barrier container 40 but not through the container 30 .
  • the descriptions of the liquid-filled combination container 10L in the first embodiment, the second embodiment, and the modifications 1 to 11 refer to the barrier container first position 45a and the barrier container second position 45b. It can also be applied to the liquid-filled combination container 10L in which the oxygen concentration in the barrier container 40 is measured.
  • the description of the oxygen reactant storage portion 49a in Modifications 10 and 11 has the barrier container first position 45a and the barrier container second position 45b, and the It can also be applied to the oxygen reactant storage part of the liquid-filled combination container 10L whose oxygen concentration is to be measured.
  • the description of the inspection method for inspecting the oxygen concentration in the container 30 in the first embodiment, the second embodiment, and the modifications 1 to 11 can be applied to the barrier container 40 shown in FIG. It can also be applied to an inspection method for inspecting the oxygen concentration inside.
  • the descriptions of the attenuation factor measurement process in the first embodiment, the second embodiment, and the modifications 1 to 11 can also be applied to the barrier container attenuation factor measurement process as long as there is no contradiction.
  • the descriptions of the measurement steps in the first embodiment, the second embodiment, and the modifications 1 to 11 are not inconsistent with the inspection method for the liquid-filled combination container 10L shown in FIG. It can also be applied to the barrier property container measurement process.
  • the oxygen concentration in the container 30 can be calculated by the method of .
  • the oxygen concentration in the barrier container 40 is measured by the inspection method of the third embodiment.
  • the measured oxygen concentration in the barrier container 40 is regarded as the oxygen concentration in the container 30 .
  • the oxygen concentration in the container 30 can be calculated by the above method. It should be noted that the case where the permeation of oxygen through the container 30 is considered to reach equilibrium between the headspace HS and the barrier container space 49 is, for example, when the liquid container 30L is accommodated in the barrier container 40. and sufficient time has elapsed since the barrier container 40 was closed for the permeation of oxygen through the container 30 to reach equilibrium.
  • FIG. 27 corresponds to a cross-sectional view of the liquid-filled combination container 10L taken along line XXVII-XXVII in FIG.
  • a liquid-filled combination container 10L of the fourth embodiment stores a liquid L in a storage portion 31, and has a container 30 having oxygen permeability, and a container 30 and has an oxygen barrier property, and at least one oxygen reactive agent 20 capable of reacting with oxygen in the barrier property container 40 .
  • the container 30 has a first position 35a and a second position 35b apart from the contact area 31a that contacts the liquid L of the container 31 .
  • the container 30 is optically transmissive at least at the first position 35a and the second position 35b.
  • the barrier container 40 has optical transparency at least at positions intersecting a straight line connecting the first position 35a and the second position 35b.
  • the liquid-filled combination container 10L of the fourth embodiment emits laser light or LED light to the first position 35a and the second position 35b of the container 30, similarly to the liquid-filled combination container 10L of the second embodiment.
  • the oxygen concentration in the container 30 can be checked by illuminating it through and measuring the attenuation rate of the laser or LED light.
  • the characteristic of the liquid-filled combination container 10L of the fourth embodiment described in this specification is that, as shown in FIG. This is a feature of the liquid-filled combination container 10L in which the liquid-filled combination container 10L is lifted without strong vibration by gripping the upper seal portion 43b of the barrier container 40 described later.
  • the oxygen reactant 20 is held in the holding space 58 formed between part of the outer surface 30b of the container 30 and part of the inner surface of the barrier container 40. .
  • a straight line connecting the first position 35 a and the second position 35 b does not pass through the holding space 58 . Therefore, by setting the straight line connecting the first position 35a and the second position 35b as the optical path LA, the laser light or the LED light can be irradiated so as to pass through the container 30 without being hindered by the oxygen reactant 20.
  • the holding space 58 formed between a portion of the outer surface 30b of the container 30 and a portion of the inner surface of the barrier container 40 of the liquid-filled combination container 10L of the fourth embodiment is similar to that of each of the above-described embodiments. It can also be said that this corresponds to the oxygen reactant accommodating portion 49a described in the form and each modified example.
  • the liquid-filled combination container 10L of the fourth embodiment has the oxygen reactant storage section 49a that stores the oxygen reactant 20 in a part of the barrier container 40 .
  • the oxygen reactant 20 can be said to be separated from the straight line (corresponding to the optical path LA) connecting the first position 35a and the second position 35b.
  • the oxygen reactant 20 is contained in the oxygen reactant containing portion 49a so that the straight line connecting the first position 35a and the second position 35b ( (corresponding to the optical path LA).
  • the container 30 of the fourth embodiment also includes a container body 32 and a stopper 34, like the container 30 of the first embodiment.
  • the container body 32 has a trunk portion 32b, a neck portion 32c and a head portion 32d.
  • the head portion 32d is a portion that forms the opening 33.
  • the neck portion 32c is a portion connected to the head portion 32d.
  • the trunk portion 32b has a width greater than that of the neck portion 32c in a direction perpendicular to the axial direction DB in which the axis LB of the container 30 extends.
  • the axis LB of the container 30 is the rotationally symmetrical axis of the container body 32 when the container body 32 has a rotationally symmetrical shape.
  • the axis LB of the container 30 is a straight line perpendicular to the imaginary plane closing the opening 33 of the container body 32 and passing through the center of gravity of the imaginary plane.
  • the container body 32 also includes a shoulder portion 32e connecting the neck portion 32c and the body portion 32b.
  • the width of the shoulder portion 32e in the direction orthogonal to the axial direction DB in which the axis LB of the container 30 extends gradually increases from the portion where it connects with the neck portion 32c toward the portion where it connects with the body portion 32b.
  • the housing portion 31 of the container 30 shown in FIGS. 26 and 27 has a circularly symmetrical shape with respect to the axis LB.
  • the cross section of the accommodating portion 31 perpendicular to the axis LB is a circle.
  • a trunk portion 32b, a neck portion 32c, and a shoulder portion 32e of the container body 32 shown in FIGS. 26 and 27 have circularly symmetrical shapes with respect to the axis LB.
  • the cross-sections of the trunk portion 32b, the neck portion 32c, and the shoulder portion 32e perpendicular to the axis LB are all circular.
  • the neck portion 32c may include a portion whose diameter does not change in the axial direction DB in which the axis LB of the container 30 extends. That is, the neck portion 32c may include a cylindrical portion extending in the axial direction DB.
  • the container 30 further includes a fixture 36 that prevents the stopper 34 from coming off the container body 32 .
  • a member for closing the opening 33 of the container body 32 such as the stopper 34 and the fixture 36 , is collectively referred to as a lid portion 74 .
  • the container 30 of the fourth embodiment has a container body 32 having an opening 33 and a lid portion 74 including a plug 34 that closes the opening 33 .
  • 26 and 27 has a circularly symmetrical shape with respect to the axis LB. In other words, the cross section of the outer surface of the lid portion 74 perpendicular to the axis LB is a circle.
  • the barrier container 40 of the fourth embodiment is a bag made of a resin film having an oxygen barrier property, and is a so-called pouch, which is different from the barrier container 40 of the first embodiment. It is the same.
  • the barrier container 40 of the fourth embodiment includes a first film 41g that forms a first surface 40d of the barrier container 40 and a second film 41g that forms a second surface 40e of the barrier container 40 facing the first surface 40d. 2 film 41h, and a seal portion 43 that joins the first film 41g and the second film 41h in at least part of the first film 41g and the second film 41h.
  • the barrier container 40 is a bag that accommodates the container 30 between the first film 41g and the second film 41h. In the example shown in FIGS. 26 and 27, the first film 41g and the second film 41h are separate films joined together. Although not shown, the first film 41g and the second film 41h may be separate parts of a single folded film divided at the folding position.
  • the sealing portion 43 joins the first film 41g and the second film 41h along the entire in-plane direction of the first film 41g and the second film 41h. .
  • the seal portion 43 is arranged so as to surround at least a portion of the first film 41g and the second film 41h when viewed from the thickness direction of the first film 41g. is joined with
  • the barrier container 40 forms a space for housing the container 30 without including an additional film such as the bottom film 41e described above in the first embodiment.
  • the first film 41g and the second film 41h have a rectangular shape with long sides extending vertically in FIG. 26 and short sides perpendicular to the long sides.
  • the sealing portion 43 is formed on the side of the first film 41g and the second film 41h on which the container body 32 is positioned with respect to the lid portion 74 (lower side in FIG. 26). It has a lower seal portion 43a that joins the parts together. Further, the sealing portion 43 is an upper sealing portion that joins the sides of the first film 41g and the second film 41h on the side opposite to the side on which the container body 32 is located with respect to the lid portion 74 (the upper side in FIG. 26). 43b. The seal portion 43 also has a first side seal portion 43c and a second side seal portion 43d that connect the lower seal portion 43a and the upper seal portion 43b.
  • the first side seal portion 43c and the second side seal portion 43d face each other in a direction orthogonal to the axial direction DB in which the axis LB of the container 30 extends.
  • the lower seal portion 43a and the upper seal portion 43b extend along the short sides of the first film 41g and the second film 41h.
  • the first side seal portion 43c and the second side seal portion 43d extend along the long sides of the first film 41g and the second film 41h.
  • the contour 43e of the lower seal portion 43a on the side facing the upper seal portion 43b gradually increases toward the midpoint between the first side seal portion 43c and the second side seal portion 43d. It has a V shape that goes away from 43b. This prevents the container 30 from moving from the center of the barrier container 40 in the horizontal direction when the upper seal portion 43b is directed upward and the lower seal portion 43a is directed downward as shown in FIG. can.
  • the distance between the first film 41g and the lid portion 74 and the distance between the second film 41h and the lid portion 74 are 20 in the thickness direction.
  • the meanings of "the thickness direction of the oxygen reactant 20" and "the width in the thickness direction of the oxygen reactant 20" will be explained.
  • the distance between the pair of imaginary surfaces when the distance between the pair of imaginary surfaces is the minimum is the width of the oxygen reactant 20 in the thickness direction.
  • the first film 41g is in contact with the lid portion 74. As shown in FIG. That is, the distance between the first film 41g and the lid portion 74 is zero.
  • the second film 41 h is in contact with the lid portion 74 . That is, the distance between the second film 41h and the lid portion 74 is zero.
  • the oxygen reactant 20 is located on the opposite side of the lid portion 74 from the side on which the container body 32 is located. In other words, the oxygen reactant 20 is positioned above the lid portion 74 in FIGS.
  • the distance between the first film 41g and the lid portion 74 and the distance between the second film 41h and the lid portion 74 are smaller than the width of the oxygen reactant 20 in the thickness direction.
  • the oxygen reactant 20 arranged on the upper side of the lid portion 74 passes between the first film 41g and the lid portion 74 or between the second film 41h and the lid portion 74, and the lid portion 74 Downward movement is suppressed.
  • the oxygen reactant 20 can be held on the upper side of the lid portion 74 .
  • the distance between the first film 41g and the lid portion 74 and the distance between the second film 41h and the lid portion 74 are smaller than the width of the oxygen reactant 20 in the thickness direction.
  • a holding space 58 for holding the oxygen reactant 20 is formed above the lid portion 74 and between a portion of the outer surface 30b of the container 30 and a portion of the inner surface of the barrier container 40 .
  • the first position 35a and the second position 35b are positioned on the lower side of FIG.
  • the distance between the first film 41g and the shoulder 32e and the distance between the second film 41h and the shoulder 32e are is smaller than the width in the thickness direction of In the example shown in FIG. 27, the first film 41g contacts the shoulder 32e. That is, the distance between the first film 41g and the shoulder 32e is zero. Also, the second film 41h is in contact with the shoulder portion 32e. That is, the distance between the second film 41h and the shoulder 32e is zero.
  • the distance between the first film 41g and the shoulder 32e and the distance between the second film 41h and the shoulder 32e are smaller than the width of the oxygen reactant 20 in the thickness direction.
  • the oxygen reactant 20 arranged on the upper side of the lid portion 74 passes between the first film 41g and the shoulder portion 32e or between the second film 41h and the shoulder portion 32e to the shoulder portion 32e. Downward movement is suppressed. This allows the oxygen reactant 20 to be retained on the upper side of the shoulder 32e.
  • the distance between the first film 41g and the shoulder 32e and the distance between the second film 41h and the shoulder 32e are smaller than the width of the oxygen reactant 20 in the thickness direction
  • a holding space 58 in which the oxygen reactant 20 is held is formed above the shoulder 32 e and between a portion of the outer surface 30 b of the container 30 and a portion of the inner surface of the barrier container 40 .
  • the first position 35a and the second position 35b are positioned on the body portion 32b of the container body 32 below the shoulder portion 32e in FIGS. 26 and 27 .
  • the distance between the first film 41g and the lid portion 74 and the distance between the second film 41h and the lid portion 74 are smaller than the width of the oxygen reactant 20 in the thickness direction, and the first film 41g and the shoulder 32e and the distance between the second film 41h and the shoulder 32e are smaller than the width of the oxygen reactant 20 in the thickness direction.
  • the distance between the first film 41g and the lid portion 74 and the distance between the second film 41h and the lid portion 74 are smaller than the width of the oxygen reactant 20 in the thickness direction, and the first film Either one of the distance between 41g and shoulder 32e and the distance between second film 41h and shoulder 32e may be smaller than the width of oxygen reactant 20 in the thickness direction.
  • the barrier container 40 of the fourth embodiment has a first contact region 59a and a second contact region 59a where portions not joined by the sealing portion 43 that joins the first film 41g and the second film 41h are in close contact with each other. It has a region 59b.
  • the first contact region 59a and the second contact region 59b are formed at positions sandwiching the container 30 in a direction perpendicular to the axial direction DB in which the axis LB of the container 30 extends.
  • FIG. 28 is a cross-sectional view showing a cross section of the liquid-filled combination container 10L taken along line XXVIII-XXVIII in FIG. FIG.
  • FIG. 29 is a cross-sectional view showing a cross section of the liquid-filled combination container 10L taken along line XXIX-XXIX in FIG.
  • first tight contact region 59a is formed between the container 30 and the first side seal portion 43c.
  • second contact region 59b is formed between the container 30 and the second side seal portion 43d.
  • the container 30 has a larger width in the thickness direction (direction DC shown in FIG. 28) of the first film 41g than the oxygen reactant 20.
  • the barrier container 40 is largely deformed to match the shape of the container 30 around the portion where the container 30 is accommodated.
  • the first tight contact region 59a is formed between the container 30 and the first side seal portion 43c by the barrier container 40 largely deforming according to the shape of the container 30 .
  • the second contact region 59b is formed between the container 30 and the second side seal portion 43d by greatly deforming the barrier container 40 according to the shape of the container 30. As shown in FIG.
  • At least a portion of the first contact region 59a and the second contact region 59b overlap with a portion of the oxygen reactant 20 in the axial direction DB. That is, at least a portion of the first contact region 59a overlaps a portion of the oxygen reactant 20 in the axial direction DB, and at least a portion of the second contact region 59b overlaps a portion of the oxygen reactant 20 in the axial direction DB. .
  • part of the first contact region 59a overlaps part of the oxygen absorber 21 and part of the oxygen detector 25 in the axial direction DB.
  • a portion of the second contact region 59b overlaps with a portion of the oxygen absorber 21 and overlaps with a portion of the oxygen detector 25 in the axial direction DB.
  • the first contact region 59a and the second contact region 59b are formed, and at least a portion of the first contact region 59a and the second contact region 59b overlap with a portion of the oxygen reactant 20 in the axial direction DB. effect is obtained.
  • Formation of the first contact region 59a suppresses the oxygen reactant 20 from entering between the first film 41g and the second film 41h between the container 30 and the first side seal portion 43c. can.
  • the formation of the second contact region 59b prevents the oxygen reactant 20 from entering between the first film 41g and the second film 41h between the container 30 and the second side seal portion 43d. can be suppressed.
  • the oxygen reactant 20 can be stably prevented from moving to a position that prevents irradiation of the laser light or the LED light so as to pass through the container 30 .
  • first contact area 59a and the second contact area 59b movement of the container 30 in the space inside the barrier container 40 can be suppressed.
  • the container 30 moves to the vicinity of the first side seal portion 43c, creating a large gap between the container 30 and the second side seal portion 43d, and the container 30 moves toward the second side seal portion 43d.
  • the distance between the first film 41g and the lid portion 74 and the distance between the second film 41h and the lid portion 74 are the same in the thickness direction of the oxygen reactant 20. and that the first contact region 59a and the second contact region 59b are formed.
  • These two features hold the oxygen reactant 20 above the lid 74 and the first and second contact areas 59a and 59b.
  • the holding space 58 in which the oxygen reactant 20 is held is formed above the lid portion 74 and the first contact region 59a and the second contact region 59b by these two features.
  • laser light or LED light can be irradiated so as to pass through the container 30 without being hindered by the oxygen reactant 20 .
  • the distance between the first side seal portion 43c and the second side seal portion 43d 1/4 of the length of the entire circumference of the container 30 in the circumferential direction DD around the axis LB is subtracted to obtain 0. It is preferable that the length multiplied by 0.8 is smaller than the maximum width of the oxygen reactant 20 in the direction orthogonal to the thickness direction.
  • the distance between the first side seal portion 43c and the second side seal portion 43d is equal to the distance between the first film 41g and the second film 41h when nothing is stored inside the barrier container 40. is defined as the distance between the first side seal portion 43c and the second side seal portion 43d when the is supported flat.
  • FIG. 30 shows a cross-sectional view of the liquid-filled combination container 10L shown in FIG. 29, in which the container 30 is moved inside the barrier container 40 to come into contact with the first side seal portion 43c.
  • the length of the curve labeled w3 corresponds to the distance between the first side seal portion 43c and the second side seal portion 43d
  • the length of the curve labeled w4 corresponds to 1/4 of the length of the entire circumference of the container 30 in the circumferential direction DD around the axis LB. Since the length of the straight line denoted by reference symbol w5 corresponds to the length obtained by subtracting the length w4 from the length w3, the distance between the first side seal portion 43c and the second side seal portion 43d is , minus 1/4 of the length of the entire circumference of the container 30 in the circumferential direction DD around the axis LB.
  • the width of the gap formed between the container 30 and the second side seal portion 43d is maximized.
  • the maximum width of the gap is the length w5.
  • the maximum width of the gap formed between the container 30 and the first side seal portion 43c is also the length w5. .
  • the container 30 will not move to the first side due to the effects of the above-described first contact area 59a and second contact area 59b. Contact with the side seal portion 43c or the second side seal portion 43d is suppressed.
  • the occurrence of a gap having a maximum width of length w5 as shown in FIG. 30 is also suppressed in normal use of the liquid-filled combination container 10L.
  • the developers of the liquid-filled combination container 10L of the fourth embodiment have made intensive studies and found that the gap formed between the container 30 and the second side seal portion 43d in normal use, or the container It was found that the maximum value of the width of the gap formed between 30 and first side seal portion 43c is 0.8 times or less of length w5. From the above, the distance between the first side seal portion 43c and the second side seal portion 43d is 0 by subtracting 1/4 of the length of the entire circumference of the container 30 in the circumferential direction DD around the axis LB.
  • the length multiplied by 0.8 is smaller than the maximum width in the direction orthogonal to the thickness direction of the oxygen reactive agent 20, the following effects are obtained. Intrusion of the oxygen reactant 20 between the container 30 and the first side seal portion 43c or between the container 30 and the second side seal portion 43d can be suppressed more stably. From the viewpoint of more stably exhibiting the effects described above, the distance between the first side seal portion 43c and the second side seal portion 43d determines the total circumference of the container 30 in the circumferential direction DD around the axis LB. It is more preferable that the length obtained by subtracting 1/4 of the length and multiplying by 0.9 is smaller than the maximum width of the oxygen reactant 20 in the direction orthogonal to the thickness direction.
  • 1/4 of the length of the entire circumference of the container 30 in the circumferential direction DD around the axis LB is subtracted from the distance between the first side seal portion 43c and the second side seal portion 43d to obtain 0.0. More preferably, the length multiplied by 95 is smaller than the maximum width in the direction orthogonal to the thickness direction of the oxygen reactive agent 20 .
  • the oxygen absorber 21 and the oxygen detector 25 that are the oxygen reactant 20 both have a rectangular shape when viewed from the thickness direction of the oxygen reactant 20 .
  • 1/4 of the length of the entire circumference of the container 30 in the circumferential direction DD around the axis LB is subtracted to obtain 0.
  • the length multiplied by 0.8 is smaller than the width of the long side of the rectangular shape of the oxygen reactant 20 .
  • 1/4 of the length of the entire circumference of the container 30 in the circumferential direction DD around the axis LB is subtracted from the distance between the first side seal portion 43c and the second side seal portion 43d to obtain 0.0.
  • the eight-fold length may be smaller than the width of the short side of the rectangular shape of the oxygen reactant 20 .
  • the container 30 is separated from the contact area 31a of the container 31 that contacts the liquid L and is positioned at the first position 35a and the second position 35b. It has a third position 35c and a fourth position 35d that are different from each other.
  • the container 30 is light transmissive at least at the third position 35c and the fourth position 35d.
  • the barrier container 40 has optical transparency at least at positions intersecting a straight line connecting the third position 35c and the fourth position 35d.
  • the liquid-filled combination container 10L emits laser light or LED light in an optical path (optical path LC) different from the optical path LA.
  • the container 30 may be permeated. This makes it possible to measure the attenuation rate of laser light or LED light in different optical paths. For this reason, for example, by measuring the oxygen concentration in the container 30 based on the attenuation rate of laser light or LED light in different optical paths and calculating the average value of the oxygen concentrations in the container 30 measured in different optical paths, The oxygen concentration in the container 30 can be calculated with higher accuracy. In the example shown in FIG.
  • the optical path LA passing through the first position 35a and the second position 35b and the optical path LC passing through the third position 35c and the fourth position 35d intersect.
  • the optical path LA and the optical path LC intersect at the position of the axis line LB.
  • the optical path LA passing through the first position 35a and the second position 35b and the optical path LC passing through the third position 35c and the fourth position 35d need not intersect.
  • a method of inspecting the liquid-filled combination container 10L in which laser light or LED light is transmitted through the container 30 in different optical paths will be described later.
  • the liquid-filled combination container 10L has a plurality of positions different from the first position 35a and the second position 35b, and the third position 35c and the fourth position 35d, where the laser light or the LED light can pass through the container 30. good too.
  • the length of the line segment located inside the container 30 on the straight line (corresponding to the optical path LA) connecting the first position 35a and the second position 35b is is equal to the length of a line segment located in the container 30 on a straight line (corresponding to the optical path LC) connecting .
  • the total length of the line segment located in the space between the container 30 and the barrier container 40 on the straight line connecting the first position 35a and the second position 35b is the third position 35c and the fourth position 35d. is equal to the sum of the lengths of the line segments located in the space between the container 30 and the barrier container 40 on a straight line connecting .
  • the barrier container 40 is in contact with the outer surface 30b of the container 30 at the first position 35a and the second position 35b at the light transmissive position, and the container 30 at the third position 35c and It contacts the outer surface 30b at the fourth location 35d. Therefore, the sum of the lengths of the line segments located in the space between the container 30 and the barrier container 40 on the straight line connecting the first position 35a and the second position 35b, the third position 35c and the fourth position 35d The sum of the lengths of the line segments located in the space between the container 30 and the barrier container 40 on the straight line connecting the .
  • the length of the line segment located inside the container 30 on the straight line connecting the first position 35a and the second position 35b is equal to the length of the line segment located inside the container 30 on the straight line connecting the third position 35c and the fourth position 35d.
  • the distance that the laser light or LED light passes through the container 30 can be aligned to measure the attenuation rate.
  • the total length of the line segment located in the space between the container 30 and the barrier container 40 on the straight line connecting the first position 35a and the second position 35b is the third position 35c and the fourth position 35d. is equal to the sum of the lengths of the line segments located in the space between the container 30 and the barrier container 40 on the straight line connecting .
  • the attenuation rate can be measured by aligning the passing distance.
  • the total length of the line segment located in the space between the container 30 and the barrier container 40 on the straight line connecting the first position 35a and the second position 35b, the third position 35c and the fourth position 35d is equal to and is not zero, the following effects are also obtained. From the attenuation rate of the laser light or LED light transmitted through the liquid-filled combination container 10L, when the oxygen concentration inside the liquid-filled combination container 10L is measured to be a value close to 0, the oxygen concentration inside the container 30 is also , the oxygen concentration in the space between the container 30 and the barrier container 40 can also be judged to be values close to zero.
  • the barrier container 40 has a first contact region 35e continuous in the circumferential direction DD around the axis LB of the container 30, and a first contact region 35e continuous in the circumferential direction DD and sandwiching the axis LB. It is in contact with the container 30 at a second contact area 35f facing 35e.
  • the first position 35a and the third position 35c are located on the first contact area 35e.
  • the second position 35b and the fourth position 35d are located on the second contact area 35f.
  • the first contact area 35e is formed by the first film 41g.
  • the second contact area 35f is formed by the second film 41h.
  • the following effects can be obtained.
  • the light source 951 is arranged at the position indicated by the solid line with reference numeral 951a in FIG. 28, and the measuring device 952 is arranged at the position indicated by the solid line with reference numeral 952a.
  • the laser light or LED light emitted from the light source 951 passes through the optical path LA to the first position 35a and the second position 35a of the container 30. It reaches the measuring device 952 through the position 35b.
  • the light source 951 is arranged at the position indicated by the broken line with reference numeral 951b
  • the measuring device 952 is arranged at the position indicated by the broken line with reference numeral 952b.
  • the laser light or LED light emitted from the light source 951 passes through the optical path LC to the third position 35c and the fourth position 35c of the container 30. It reaches the measuring device 952 through the position 35d.
  • laser light or LED light is applied to the optical path LC, the attenuation rate is measured, and the oxygen concentration in the container 30 is measured based on the attenuation rate in the optical path LC.
  • the barrier container 40 has a first contact area 35e and a second contact area 35f, a first position 35a and a third position 35c located above the first contact area 35e, and a second position 35b and a fourth position 35d. According to the liquid-filled combination container 10L located on the second contact area 35f, the following effects are obtained. By rotating the light source 951 and the measuring device 952 about the axis LB with respect to the liquid-filled combination container 10L, the light source 951, measuring devices 952 can be placed at positions indicated by reference numerals 951b, 952b.
  • a light source 951 and a measuring device 952 can be placed at positions indicated by reference numerals 951b and 952b. Therefore, by rotating either the light source 951 and the measuring device 952 or the liquid-filled combination container 10L around the axis LB, the light source 951 and the measuring device 952 can be coded without the need for other operations. It can be placed at the position indicated by 951b, 952b.
  • the liquid-filled combination container 10L and the light source 951 and The positional relationship with the measuring instrument 952 can be easily aligned.
  • the distance between the liquid-filled combination container 10L and the light source 951 can be easily aligned.
  • the distance between the liquid-filled combination container 10L and the measuring device 952 can be easily aligned.
  • the following effects are obtained by having the first contact area 35e continuous in the circumferential direction DD and the second contact area 35f continuous in the circumferential direction DD.
  • the light source 951 is moved from the position indicated by reference numeral 951a to the position indicated by reference numeral 951b, and the measuring device 952 is moved from the position indicated by reference numeral 952a to the position indicated by reference numeral 952b.
  • Laser light or LED light can be irradiated from 951 to the liquid-filled combination container 10L to reach the measuring device 952 .
  • the oxygen concentration in container 30 can be determined based on the rate. Thus, by measuring the oxygen concentration in the container 30 based on the attenuation factors in different optical paths and calculating the average value, the oxygen concentration in the container 30 can be calculated with higher
  • one end 35g of the first contact region 35e in the circumferential direction DD and the axis LB are connected on a virtual plane perpendicular to the axis LB and passing through the first contact region 35e and the second contact region 35f.
  • the angle ⁇ 1 between the straight line LD and the straight line LE connecting the other end 35h of the first contact region 35e in the circumferential direction DD and the axis LB may be 120° or more.
  • a straight line LF connecting one end 35i of the second contact region 35f in the circumferential direction DD and the axis LB, and the other end 35j of the second contact region 35f in the circumferential direction DD.
  • the angle ⁇ 2 formed between the straight line LG connecting the axis LB and the angle ⁇ 2 may be 120° or more. In other words, there may exist a virtual plane where the angle ⁇ 1 is 120° or more and the angle ⁇ 2 is 120° or more.
  • FIG. 28 corresponds to a cross section of the liquid-filled combination container 10L taken along a plane perpendicular to the axis LB and passing through the first contact area 35e and the second contact area 35f.
  • a straight line LD connecting one end 35g of the first contact region 35e in the circumferential direction DD and the axis LB, and the other end 35h of the first contact region 35e in the circumferential direction DD and the axis LB forms an angle ⁇ 1 with a straight line LE connecting .
  • a straight line LF connecting one end 35i of the second contact region 35f in the circumferential direction DD and the axis LB, and a straight line LG connecting the other end 35j of the second contact region 35f in the circumferential direction DD and the axis LB forms an angle ⁇ 2.
  • the angle ⁇ 1 in FIG. 28 is 120° or more and the angle ⁇ 2 is 120° or more
  • the cross section shown in FIG. It can be said that it corresponds to a virtual plane.
  • straight line LD and straight line LF are positioned on the same straight line.
  • the end portion 35g, the axis LB, and the end portion 35i are positioned on the same straight line.
  • the straight line LE and the straight line LG are positioned on the same straight line.
  • the end portion 35h, the axis LB, and the end portion 35j are positioned on the same straight line.
  • the first position 35a and the third position 35c are arranged on the first contact area 35e, and the second position 35b and the second position 35b are arranged on the first contact area 35e.
  • the fourth position 35d is arranged on the second contact area 35f, the angle ⁇ 3 formed by the optical path LA passing through the first position 35a and the second position 35b and the optical path LC passing through the third position 35c and the fourth position 35d is increased. can. In the example shown in FIG. 28, the angle ⁇ 3 can be 120° at maximum.
  • the third position 35c is positioned far away from the first position 35a
  • the fourth position 35d is positioned far away from the second position 35b
  • the optical path LC is positioned far away from the optical path LA.
  • the attenuation rate in the optical path passing through positions different from the first position 35a and the third position 35c on the first contact region 35e and positions different from the second position 35b and the fourth position 35d on the second contact region 35f When measuring the oxygen concentration in the container 30 on the basis of , a wide area can be secured for arranging the position through which the optical path passes.
  • the liquid-filled combination container 10L may further include a label 30c.
  • 31 is a front view showing an example of a liquid-filled combination container 10L of Modified Example 12.
  • FIG. FIG. 32 is a cross-sectional view showing another example of the liquid-filled combination container 10L of the twelfth modification. In FIGS. 31 and 32, it is attached to the outer surface 30b of the container 30 at a portion forming the body portion 32b.
  • the label 30c has an adhesive layer or adhesive layer. In this case, the label 30c is attached to the outer surface 30b of the container 30 by bonding at least part of the label 30c to the outer surface 30b of the container 30 with an adhesive layer or adhesive layer.
  • the entire outer edge of label 30c is bonded to outer surface 30b of container 30 by an adhesive or sticky layer.
  • the label 30c displays information such as characters and pictures.
  • the label 30c displays the name of the liquid L contained in the container 30 and an explanation about the fluid L.
  • the label 30c is devised so that the label 30c does not interfere with the irradiation of the laser light or the LED light so as to pass through the container 30.
  • a label 30c shown in FIG. 31 has a label light transmitting portion 30d.
  • the shape of the label light transmitting portion 30d is not particularly limited as long as it allows light to pass through.
  • the label light-transmitting portion 30d is made of a light-transmitting material.
  • the label light transmission portion 30d may be a through hole provided in the label 30c. Since the label 30c has the label light-transmitting portion 30d, the liquid-filled combination container 10L is provided with the label 30c by arranging the first position 35a and the second position 35b at positions overlapping the label light-transmitting portion 30d of the container 30.
  • laser light or LED light can be irradiated so as to pass through the first position 35 a and the second position 35 b of the container 30 .
  • the label 30c of the container 30 can be Laser light or LED light can be irradiated so as to pass through the third position 35c and the fourth position 35d.
  • the label light transmitting portion 30d extends in the circumferential direction DD around the axis LB of the container 30.
  • the first position 35a, the second position 35b, A third position 35c and a fourth position 35d can be arranged. Therefore, the following effects are obtained.
  • the light source 951 and the measuring device 952 are arranged such that the light emitted from the light source 951 passes through the first position 35a and the second position 35b and reaches the measuring device 952.
  • the light emitted from the light source 951 can be is transmitted through the third position 35 c and the fourth position 35 d to reach the measuring device 952 .
  • the label 30c shown in FIG. 32 is provided at a position that does not overlap the first position 35a and the second position 35b of the container 30. Also by this, laser light or LED light can be irradiated so that the 1st position 35a and the 2nd position 35b of the container 30 may be permeate
  • the label 30c is provided at a position closer to the bottom 32a of the container body 32 than the first position 35a and the second position 35b in the axial direction DB in which the axis LB of the container 30 extends. Because of this, the label 30c does not overlap the container 30 at the first position 35a and the second position 35b. Although not shown, the label 30c does not overlap the first position 35a and the second position 35b of the container 30 because the label 30c overlaps only a part of the circumferential direction DD around the axis LB of the container 30. good too. Also, the entire outer edge of the label 30c does not have to be bonded to the outer surface 30b of the container 30 .
  • the label 30c may have a rectangular shape, and only the outer edge of the label 30 c forming one side of the rectangle may be joined to the outer surface 30 b of the container 30 . In this case, the label 30c may not be attached to cover the outer surface 30b of the container 30 as a whole.
  • the label 30c may have light transmittance as a whole, except for a portion that displays information such as characters and patterns.
  • the label 30c may have light transmittance as a whole, except for a portion that displays information such as characters and patterns.
  • the laser light or the LED light can be irradiated so as to pass through the first position 35 a and the second position 35 b of the container 30 .
  • the laser light or the LED light can be irradiated so as to pass through the third position 35 c and the fourth position 35 d of the container 30 .
  • FIG. 33 is a cross-sectional view showing an example of a liquid-filled combination container 10L of Modified Example 13.
  • FIG. FIG. 34 is a cross-sectional view showing another example of the liquid-filled combination container 10L of the thirteenth modification.
  • the first position 35a and the second position 35b are located on the neck 32c.
  • the third position 35c and the fourth position 35d are located at the neck portion 32c.
  • the neck portion 32c of the container 30 shown in FIGS. 33 and 34 has a circularly symmetrical shape with respect to the axis LB of the container 30. As shown in FIG. A label 30c is attached to a portion of the outer surface 30b of the container 30 that constitutes the body portion 32b.
  • the first position 35a and the second position 35b are located at the neck portion 32c, even when the label 30c is attached to the body portion 32b, the first position 35a and the second position 35b of the container 30 can be easily moved without being hindered by the label 30c.
  • Laser light or LED light can be irradiated so as to pass through the position 35a and the second position 35b.
  • the third position 35c and the fourth position 35d are located on the neck portion 32c, even if the label 30c is attached to the body portion 32b, the container 30 can be moved without being hindered by the label 30c.
  • Laser light or LED light can be irradiated so as to pass through the third position 35c and the fourth position 35d.
  • the barrier container 40 is in contact with the outer surface 30b at the first position 35a and the second position 35b located at the neck 32c of the container 30 at the positions having light transmission properties.
  • the barrier container 40 may be in contact with the outer surface 30b at the third position 35c and the fourth position 35d located at the neck 32c of the container 30 at positions having light transmission properties.
  • the method of contacting the barrier container 40 with the outer surface 30b of the first position 35a and the second position 35b located at the neck 32c of the container 30 is to place the barrier container 40 against the outer surface 30b of the first position 35a and the second position 35b.
  • the film forming the barrier container 40 is made of a shrink film. In this case, by applying heat to the shrink film that constitutes the barrier container 40 to cause it to shrink, the portion of the barrier container 40 formed by the shrink film is placed on the outer surface 30b of the first position 35a and the second position 35b.
  • the barrier container 40 can be contacted.
  • the barrier container 40 is pushed toward the outer surface 30b of the first position 35a and the second position 35b from the outside with a jig, thereby moving the barrier container 40 to the first position 35a and the second position 35b. It can be in contact with the outer surface 30b.
  • the container described in each of the above-described embodiments and modifications is used, unless inconsistent.
  • a method of contacting the outer surface 30b of the first position 35a and the second position 35b located on the body 32b of the body 30 can also be applied.
  • the neck 32c of the container 30 shown in FIG. 33 has a shape that is circularly symmetrical with respect to the axis LB of the container 30.
  • the barrier container 40 is in contact with the outer surface 30b at the first and second locations 35a and 35b located at the neck 32c of the container 30, and at the third and third locations 35c and 35c located at the neck 32c of the container 30.
  • the following effects are obtained by being in contact with the outer surface 30b at the 4-position 35d.
  • the length of the line segment located in the container 30 on the straight line connecting the first position 35a and the second position 35b is It can be equal to the length of the line segment located within the container 30 on the straight line connecting the 4 positions 35d.
  • the total length of the line segment located in the space between the container 30 and the barrier container 40 on the straight line connecting the first position 35a and the second position 35b, and the distance between the third position 35c and the fourth position 35d The sum of the lengths of the line segments located in the space between the container 30 and the barrier container 40 on the straight line connecting .
  • the attenuation rate can be measured by aligning the distance through which the laser light or the LED light passes through the space between the container 30 and the barrier container 40 .
  • the barrier container 40 has a portion that contacts the lid portion 74 and a portion that contacts the shoulder portion 32 e of the container 30 .
  • the barrier container 40 is tightly stretched between the lid portion 74 and the shoulder portion 32e.
  • the barrier container 40 contacts the lid portion 74 and the shoulder portion 32e at a portion in the circumferential direction DD around the axis LB of the container 30, and is stretched between the lid portion 74 and the shoulder portion 32e.
  • the barrier container 40 is in contact with the lid portion 74 and the shoulder portion 32e and stretched between the lid portion 74 and the shoulder portion 32e throughout the circumferential direction DD around the axis LB of the container 30. good too.
  • the outer surface of the lid portion 74 shown in FIG. 34 has a circularly symmetrical shape with respect to the axis LB of the container 30 .
  • a portion of the barrier container 40 is in surface contact with the side surface of the lid portion 74 .
  • a shoulder portion 32e of the container 30 shown in FIG. 34 has a shape that is circularly symmetrical with respect to the axis LB.
  • a portion of the barrier container 40 is in contact with the portion of the shoulder portion 32e that is connected to the body portion 32b.
  • the method of bringing a portion of the barrier container 40 into contact with the lid portion 74 and the other portion into contact with the shoulder portion 32e is not particularly limited.
  • the container 30 and the barrier container 40 are arranged so that part of the barrier container 40 naturally contacts the lid portion 74 and another portion contacts the shoulder portion 32e. may be designed.
  • a part of the barrier container 40 may be brought into contact with the lid 74 or the shoulder 32e by pressing the barrier container 40 from the outside toward the lid 74 or the shoulder 32e with a jig.
  • a straight line connecting the first position 35a and the second position 35b (corresponding to the optical path LA) is aligned with the lid portion 74 and the shoulder of the barrier container 40.
  • It is arranged so as to pass through the stretched portion between the portion 32e.
  • the straight line connecting the third position 35c and the fourth position 35d is between the lid portion 74 and the shoulder portion 32e of the barrier container 40. It may be arranged so as to pass through the part stretched in the.
  • the neck portion 32c of the container 30 shown in FIG. 34 has a shape that is circularly symmetrical with respect to the axis LB of the container 30.
  • 34 has a circularly symmetrical shape with respect to the axis LB of the container 30.
  • a shoulder portion 32e of the container 30 shown in FIG. 34 has a shape that is circularly symmetrical with respect to the axis LB.
  • the first position 35a and the second position 35a are arranged such that the straight line connecting the first position 35a and the second position 35b passes through the portion stretched between the lid portion 74 and the shoulder portion 32e of the barrier container 40.
  • the second position 35b is arranged so that a straight line connecting the third position 35c and the fourth position 35d passes through the portion of the barrier container 40 stretched between the lid portion 74 and the shoulder portion 32e.
  • the following effects are obtained by arranging the third position 35c and the fourth position 35d. While arranging the first position 35a and the second position 35b on the neck 32c, the length of the line segment located in the container 30 on the straight line connecting the first position 35a and the second position 35b is It can be equal to the length of the line segment located within the container 30 on the straight line connecting the 4 positions 35d.
  • the total length of the line segment located in the space between the container 30 and the barrier container 40 on the straight line connecting the first position 35a and the second position 35b is defined as the third position 35c and the fourth position 35d.
  • the attenuation rate can be measured by aligning the distance through which the laser light or the LED light passes through the space between the container 30 and the barrier container 40 .
  • FIG. 35 is a diagram explaining the fifth embodiment of the present disclosure.
  • the liquid-filled combination container 10L of the fifth embodiment stores the liquid L in the storage portion 31, and has an oxygen permeability, similar to the liquid-filled combination container 10L of the first embodiment.
  • a barrier container 40 having oxygen barrier properties, at least one oxygen reactive agent 20 capable of reacting with oxygen in the barrier container 40, and fluorescence time or fluorescence intensity depending on the ambient oxygen concentration.
  • a different fluorescent material 27 is provided on the inner surface 30a of the housing portion 31 of the container 30 at the fluorescent material installation position 39 away from the contact area 31a that contacts the liquid L.
  • the container 30 has optical transparency at least at the fluorescent material installation position 39 .
  • the barrier container 40 has a light transmission position 40b having light transmission properties.
  • the fluorescent material 27 is irradiated with light that causes the fluorescent material 27 to fluoresce. By measuring time or fluorescence intensity, the oxygen concentration in container 30 can be checked.
  • the feature of the liquid-filled combination container 10L of the fifth embodiment described in this specification is that the container 30, the oxygen reactant 20 and the fluorescent material 27 are barriers as shown in FIG.
  • the liquid-filled combination container 10L is housed in the liquid-filled container 40, gripped by an upper seal portion 43b of the barrier container 40 to be described later, and lifted without strong vibration. be.
  • the holding space 58 is not located between the fluorescent material installation position 39 and the light transmitting position 40b. Therefore, by allowing the light that causes the fluorescent material 27 to fluoresce through the light transmission position 40b of the barrier container 40 and the fluorescent material installation position 39 of the container 30, the light is emitted to the fluorescent material without being blocked by the oxygen reactive agent 20. 27 can be irradiated.
  • the explanation regarding the holding space 58 described above in the fourth embodiment and each modification also applies to the liquid-filled combination container 10L of the fifth embodiment.
  • the holding space 58 formed between a portion of the outer surface 30b of the container 30 and a portion of the inner surface of the barrier container 40 in the liquid-filled combination container 10L of the fifth embodiment is similar to that of each of the above-described embodiments. It can also be said that it corresponds to the oxygen reactant accommodating portion 49a described in the form and each modified example. In other words, it can be said that the liquid-filled combination container 10L of the fifth embodiment is such that the oxygen reactant containing portion 49a for containing the oxygen reactant 20 is partitioned in a part of the barrier container 40 .
  • the oxygen reactant 20 is accommodated in the oxygen reactant accommodating portion 49a so that the oxygen reactant 20 is placed between the fluorescent material installation position 39 and the light transmission position 40b. It can be said that they are arranged in a position where they are not pinched.
  • the sixth embodiment relates to an inspection method for the liquid-filled combination container 10L.
  • the inspection method of the sixth embodiment includes a container 30 containing a liquid L in a container 31 and having oxygen permeability, a barrier container 40 containing the container 30 and having an oxygen barrier property, and a barrier container 40 having an oxygen barrier property.
  • the container 30 has a first position 35a and a second position 35b apart from the contact area 31a that contacts the liquid L of the container 31 .
  • the container 30 is optically transmissive at least at the first position 35a and the second position 35b.
  • the barrier container 40 has optical transparency at least at positions intersecting a straight line connecting the first position 35a and the second position 35b.
  • the inspection method of the sixth embodiment can be widely applied to the liquid-filled combination container 10L described above.
  • a method of inspecting the liquid-filled combination container 10L of the fourth embodiment will be described unless otherwise specified.
  • the inspection method of the sixth embodiment includes an arrangement process, an attenuation factor measurement process, and a measurement process.
  • the oxygen reactant 20 is arranged at a position separated from a straight line connecting the first position 35a and the second position 35b.
  • the attenuation rate measuring step laser light or LED light having a wavelength that is attenuated according to the oxygen concentration in the optical path is applied to the light-transmissive position of the barrier container 40 and the first position 35 a and the second position 35 b of the container 30 .
  • the liquid-filled combination container 10L is irradiated so as to transmit the , and the attenuation rate of the laser light or the LED light is measured.
  • the oxygen concentration in the container 30 is measured based on the attenuation factor measured in the attenuation factor measuring process.
  • the inspection method of the sixth embodiment further includes an additional placement process, an additional attenuation factor measurement process, an additional measurement process, and an average value calculation process.
  • the oxygen reactant 20 is placed at a position away from the straight line connecting the third position 35c and the fourth position 35d.
  • laser light or LED light having a wavelength that is attenuated according to the oxygen concentration in the optical path is applied to the light-transmitting position of the barrier container 40 and the third position 35c and the fourth position of the container 30.
  • the liquid-filled combination container 10L is irradiated so as to pass through 35d, and the attenuation rate of laser light or LED light is measured.
  • the oxygen concentration in container 30 is measured based on the attenuation rate measured in the additional attenuation rate measurement step.
  • the average value calculation step the average oxygen concentration in the container 30 is calculated from a plurality of measured oxygen concentrations including at least the oxygen concentration measured in the measurement step and the oxygen concentration measured in the additional measurement step.
  • the inspection method of the sixth embodiment further includes a contact step of bringing the barrier container 40 into contact with the outer surface 30 b of the container 30 .
  • the barrier container 40 is brought into contact with the outer surface 30b of the container 30 in the contact step.
  • the barrier container 40 is brought into contact with the outer surface 30b of the container 30 at the first position 35a and the second position 35b.
  • the barrier container 40 is brought into contact with the outer surface 30b of the container 30 at the first position 35a and the second position 35b, and the outer surface 30b of the container 30 at the third position 35c and the fourth position 35d. good.
  • the barrier container 40 is divided into a first contact region 35e continuous in the circumferential direction DD around the axis LB of the container 30, and a first contact region 35e continuous in the circumferential direction DD and sandwiching the axis LB. You may contact with the container 30 in the 2nd contact area
  • the first contact area 35e is formed such that the first location 35a and the third location 35c are located on the first contact area 35e.
  • the second contact area 35f is formed such that the second location 35b and the fourth location 35d are located on the second contact area 35f.
  • the contact step on a virtual plane perpendicular to the axis LB and passing through the first contact region 35e and the second contact region 35f, one end 35g of the first contact region 35e in the circumferential direction DD and the axis LB
  • the angle ⁇ 1 between the connecting straight line LD and the straight line LE connecting the other end 35h of the first contact region 35e in the circumferential direction DD and the axis LB may be 120° or more.
  • a straight line LF connecting one end 35i of the second contact region 35f in the circumferential direction DD and the axis LB, and the other end 35j of the second contact region 35f in the circumferential direction DD.
  • the angle ⁇ 2 formed between the straight line LG connecting the axis LB and the angle ⁇ 2 may be 120° or more.
  • the barrier container 40 is in contact with the container 30 in the first contact area 35e and the second contact area 35f. are in contact with
  • the contact step is , the operation may be performed.
  • the oxygen reactant 20 is arranged at a position separated from the straight line connecting the first position 35a and the second position 35b. It should be noted that placing the oxygen reactant 20 at a position spaced apart from the straight line connecting the first position 35a and the second position 35b in the placement step means that the oxygen reactant 20 is placed at the first position 35a and the second position 35b from the beginning. 35b, keeping the position of the oxygen reactant 20 unchanged.
  • the oxygen reactant 20 is held in the holding space 58, so that the oxygen reactant 20 is separated from the straight line connecting the first position 35a and the second position 35b. placed in a spaced apart position.
  • the oxygen reactant 20 is held in the holding space 58 so that it is arranged at a position separated from the straight line connecting the first position 35a and the second position 35b. , keeping the position of the oxygen reactant 20 unchanged.
  • the oxygen reaction agent 20 is positioned away from the straight line connecting the first position 35a and the second position 35b. Change the placement of the agent 20 .
  • the oxygen reactant 20 is positioned so that the oxygen reactant 20 is away from the straight line connecting the first position 35a and the second position 35b and away from the straight line connecting the third position 35c and the fourth position 35d. You can change it. In this case, it can be considered that the placement step and the additional placement step, which will be described later, are performed at the same time.
  • the attenuation rate measuring step laser light or LED light having a wavelength that is attenuated according to the oxygen concentration in the optical path is applied to the light-transmissive position of the barrier container 40 and the first position 35 a and the second position 35 b of the container 30 .
  • the liquid-filled combination container 10L is irradiated so as to transmit the , and the attenuation rate of the laser light or the LED light is measured.
  • the description of the attenuation rate measurement step of the inspection method for the liquid-filled combination container 10L of the second embodiment also applies to the attenuation rate measurement step of the inspection method of the sixth embodiment.
  • the oxygen concentration in the container 30 is measured based on the attenuation rate measured in the attenuation rate measurement process.
  • the description of the measurement process of the inspection method for the liquid-filled combination container 10L of the second embodiment also applies to the attenuation rate measurement process of the inspection method of the sixth embodiment.
  • the oxygen reactant 20 is arranged at a position separated from the straight line connecting the third position 35c and the fourth position 35d. It should be noted that, in the additional arrangement step, the oxygen reactant 20 is positioned away from the straight line connecting the third position 35c and the fourth position 35d. This includes maintaining the position of the oxygen reactant 20 unchanged, ensuring that it is positioned away from the straight line connecting position 35d.
  • the oxygen reactant 20 is held in the holding space 58, so that the oxygen reactant 20 is separated from the straight line connecting the first position 35a and the second position 35b. It is arranged at a position spaced apart and away from a straight line connecting the third position 35c and the fourth position 35d.
  • the oxygen reactant 20 is held in the holding space 58 and is spaced apart from the straight line connecting the third position 35c and the fourth position 35d. to keep the position of the oxygen reactant 20 unchanged.
  • the oxygen reactant 20 is placed away from the straight line connecting the third position 35c and the fourth position 35d. The arrangement of reactants 20 is changed.
  • the inspection method according to the sixth embodiment further includes a measuring device placement change step of changing the placement of the light source 951 and the measuring device 952 at least after the attenuation rate measurement step and before the additional attenuation rate measurement step described later.
  • the measuring device arrangement change step the light source 951 and the measuring device 952 are arranged so that the light emitted from the light source 951 is transmitted through the first position 35a and the second position 35b and reaches the measuring device 952. , so that the light emitted from the light source 951 is transmitted through the third position 35 c and the fourth position 35 d and reaches the measuring device 952 .
  • the contacting step by bringing the barrier container 40 into contact with the container 30 at the first contact region 35e and the second contact region 35f, the light source 951 and the measuring device 952 or the liquid-filled combination container 10L can be selected in the measurement device arrangement change. By rotating one of them about the axis LB, the arrangement of the light source 951 and the measuring device 952 can be changed without any other operation. Further, in the contact step, the following effects can be obtained by setting the angle ⁇ 1 to 120° or more and the angle ⁇ 2 to 120° or more.
  • the third position 35c is arranged at a position far away from the first position 35a
  • the fourth position 35d is arranged at a position far away from the second position 35b
  • the optical path LC is arranged at a position far away from the optical path LA.
  • the oxygen concentration in the container 30 can be measured based on the attenuation factors in the optical paths LA and LC.
  • the additional attenuation rate measurement step laser light or LED light having a wavelength that is attenuated according to the oxygen concentration in the optical path is applied to the light-transmitting position of the barrier container 40 and the third position 35c and the fourth position of the container 30.
  • the liquid-filled combination container 10L is irradiated so as to pass through 35d, and the attenuation rate of laser light or LED light is measured.
  • the method of measuring the attenuation rate by irradiating the liquid-filled combination container 10L with laser light or LED light so as to pass through the third position 35c and the fourth position 35d to measure the attenuation rate is as described above.
  • a method of measuring the attenuation rate by irradiating the liquid-filled combination container 10L with laser light or LED light so as to pass through the first position 35a and the second position 35b can be applied.
  • the length of the line segment located in the container 30 on the straight line connecting the first position 35a and the second position 35b is the length of the straight line connecting the third position 35c and the fourth position 35d ( equal to the length of a line segment located within the container 30 on the optical path LC).
  • the total length of the line segment located in the space between the container 30 and the barrier container 40 on the straight line connecting the first position 35a and the second position 35b is the third position 35c and the fourth position 35d. is equal to the sum of the lengths of the line segments located in the space between the container 30 and the barrier container 40 on a straight line connecting .
  • the first position 35a, the second position 35a, the second position 35d, and the first position 35a, the second position 35b, the third position 35c, and the fourth position 35d are arranged so as to satisfy the above-described positional relationship.
  • 35b, a third position 35c and a fourth position 35d are arranged for inspection.
  • the length of the line segment located inside the container 30 on the straight line connecting the first position 35a and the second position 35b is equal to the length of the line segment located inside the container 30 on the straight line connecting the third position 35c and the fourth position 35d.
  • the total length of the line segment located in the space between the container 30 and the barrier container 40 on the straight line connecting the first position 35a and the second position 35b is the third position 35c and the fourth position 35d. is equal to the sum of the lengths of the line segments located in the space between the container 30 and the barrier container 40 on the straight line connecting .
  • the attenuation rate can be measured by aligning the passing distance.
  • the oxygen concentration in the container 30 is measured based on the attenuation rate measured in the additional attenuation rate measurement process.
  • the method of measuring the oxygen concentration in the container 30 based on the attenuation rate measured in the additional attenuation rate measurement step unless contradictory, in the above-described measurement step, the attenuation measured in the attenuation rate measurement step A method of measuring the oxygen concentration in the container 30 based on the rate can be applied.
  • the average oxygen concentration in the container 30 is calculated from a plurality of measured oxygen concentrations including at least the oxygen concentration measured in the measurement step and the oxygen concentration measured in the additional measurement step.
  • the inspection method includes an additional attenuation rate measurement step, an additional measurement step, and an average value calculation step, so that the oxygen concentration in the container 30 is measured based on the attenuation rate of the laser light or LED light in different optical paths. , the average oxygen concentration in the container 30 measured in different optical paths can be calculated. Thereby, the oxygen concentration in the container 30 can be calculated with higher accuracy.
  • the barrier container 40 of the liquid-filled combination container 10L to which the inspection method of the modification 14 is applied consists of the first film 41g forming the first surface 40d of the barrier container 40 and the barrier container 40 facing the first surface 40d. and a seal portion 43 that joins the first film 41g and the second film 41h in at least a part of the first film 41g and the second film 41h.
  • the barrier container 40 is a bag that accommodates the container 30 between the first film 41g and the second film 41h.
  • the first tensile region 35m of the barrier container 40 which does not overlap the container 30 when viewed from the thickness direction of the first film 41g, and the container 30 when viewed from the thickness direction of the first film 41g.
  • the barrier container 40 is brought into contact with the outer surface 30b of the container 30 at the first location 35a and the second location 35b by pulling the sandwiching first tension region 35m and the opposing second tension region 35n away from each other.
  • the area of the barrier container 40 enclosed by the dashed line labeled 35m is the first tension area 35m.
  • the first tensile region 35m is located on the side where the first side seal portion 43c is located relative to the container 30 when the liquid-filled combination container 10L is viewed from above in the thickness direction of the first film 41g.
  • a region of the barrier container 40 surrounded by a dashed line labeled 35n is the second tensile region 35n.
  • the second tensile region 35n is located on the side where the second side seal portion 43d is located relative to the container 30 when the liquid-filled combination container 10L is viewed from above in the thickness direction of the first film 41g.
  • the barrier container 40 can be pulled away from each other. This allows the barrier container 40 to contact the outer surface 30b of the container 30 at the first position 35a and the second position 35b.
  • the barrier container 40 is brought into contact with the outer surface 30b at the first location 35a and the second location 35b, and at the third location 35c and the fourth location 35d. It may contact the outer surface 30b.
  • the barrier container 40 may be brought into contact with the container 30 at the first contact region 35e and the second contact region 35f by pulling the first tensile region 35m and the second tensile region 35n.
  • the attenuation factor measurement step or the additional attenuation factor measurement step can be performed while the barrier container 40 is in contact with the outer surface 30 b of the container 30 .
  • the first tension region 35m may be arranged on the side of the container 30 where the upper seal portion 43b is located, and the second tension region 35n may be arranged on the side of the container 30 where the lower seal portion 43a is located.
  • the first pulling region 35m is pulled toward the side where the upper sealing portion 43b is located with respect to the container 30, and the second pulling region 35n is pulled toward the side where the lower sealing portion 43a is located with respect to the container 30.
  • the barrier container 40 can contact the outer surface 30b of the container 30 at the first location 35a and the second location 35b.
  • Arranging the first pulling region 35m on the side of the container 30 where the upper sealing portion 43b is located, and arranging the second pulling region 35n on the side of the container 30 where the lower sealing portion 43a is located requires a barrier.
  • the gravity of the container 30 placed on the inner surface of the barrier container 40 causes the region of the barrier container 40 to become the base point from which the liquid-filled combination container 10L is hung. and the area of barrier container 40 on which container 30 rests are pulled away from each other.
  • the inspection method includes a contacting step of contacting the barrier container 40 with the outer surface 30b of the first position 35a and the second position 35b of the container 30, the barrier container 40 is pushed from the outside to The barrier container 40 may be brought into contact with the outer surface 30b of the first position 35a and the second position 35b of the container 30 by a pushing member 96 that contacts 30b.
  • 37A and 37B are diagrams showing an example of the contacting step in the inspection method of Modification 15. FIG.
  • the barrier container 40 is a bag containing a container 30, having a first film 41g, a second film 41h, and a seal portion 43.
  • the pushing member 96 has a first portion 96a that pushes the first film 41g of the barrier container 40 from the outside of the barrier container 40, and a second portion 96a that pushes the second film 41h of the barrier container 40 from the outside of the barrier container 40. and two portions 96b.
  • the first film 41g is pushed by the first portion 96a and the second film 41h is pushed by the second portion 96b, so that the barrier container 40 contacts the outer surface 30b of the container 30 at the first position 35a and the second position 35b. do.
  • the pressing member 96 overlaps the area surrounding the first position 35 a of the container 30 and the area surrounding the second position 35 b of the container 30 .
  • the pressing member 96 has a pressing member light transmitting portion 96c.
  • the pressing member light transmitting portion 96 c overlaps the first position 35 a and the second position 35 b of the container 30 .
  • the shape of the pressing member light transmitting portion 96c is not particularly limited as long as it allows light to pass through.
  • the pressing member light transmitting portion 96c is made of a light transmitting material.
  • the pressing member light transmitting portion 96c may be a through hole provided in the pressing member light transmitting portion 96c. Since the pressing member 96 has the pressing member light transmitting portion 96c, the barrier container 40 is pressed against the outer surface 30b of the container 30 at the first position 35a and the second position 35b of the container 30 by the pressing member 96. Laser light or LED light can be irradiated so as to pass through the first position 35a and the second position 35b.
  • the pushing member 96 may bring the barrier container 40 into contact with the outer surface 30b of the container 30 at the third position 35c and the fourth position 35d.
  • the pressing member 96 may further have a pressing member light transmitting portion 96c that overlaps the third position 35c and the fourth position 35d of the container 30 .
  • the barrier container 40 is transmitted through the third position 35c and the fourth position 35d of the container 30. can be irradiated with laser light or LED light.
  • the pushing member 96 may bring the barrier container 40 into contact with the outer surface 30b of the container 30 at the first position 35a and the second position 35b without overlapping the container 30 at the first position 35a and the second position 35b.
  • the barrier container 40 is kept in contact with the outer surface 30b of the first position 35a and the second position 35b of the container 30 by the pressing member 96, and the barrier container 40 passes through the first position 35a and the second position 35b of the container 30.
  • Laser light or LED light can be applied so as to do so.
  • the pressing member 96 may bring the barrier container 40 into contact with the outer surface 30b of the container 30 at the third position 35c and the fourth position 35d without overlapping the container 30 at the third position 35c and the fourth position 35d.
  • the barrier container 40 is in contact with the outer surface 30b of the container 30 at the third position 35c and the fourth position 35d of the container 30 by the pressing member 96.
  • Laser light or LED light can be applied so as to do so.
  • the container 30 of the liquid-filled combination container 10L to which the inspection method of Modification 16 is applied has a container body 32 having an opening 33 and a lid 74 including a plug 34 that closes the opening 33 .
  • the container body 32 includes a head portion 32d forming an opening 33, a neck portion 32c connected to the head portion 32d, and a width larger than that of the neck portion 32c in a direction orthogonal to an axial direction DB in which the axis LB of the container 30 extends. and a shoulder portion 32e connecting the neck portion 32c and the trunk portion 32b.
  • the inspection method of modification 16 can be applied to the liquid-filled combination container 10L shown in FIGS.
  • the first position 35a and the second position 35b are located at the neck 32c. In other words, the first position 35a and the second position 35b are placed on the neck 32c to perform the attenuation rate measurement step.
  • the third position 35c and the fourth position 35d may be positioned at the neck portion 32c. In other words, the third position 35c and the fourth position 35d may be arranged on the neck 32c to perform the attenuation rate measurement process.
  • the label 30c is Laser light or LED light can be directed through the first location 35a and the second location 35b of the container 30 without obstruction.
  • the third position 35c and the fourth position 35d are located on the neck portion 32c, even if the label 30c is attached to the body portion 32b, the container 30 can be moved without being hindered by the label 30c. Laser light or LED light can be irradiated so as to pass through the third position 35c and the fourth position 35d.
  • Modification 17 In the inspection method of the modification 17, after confirming that the movement of oxygen between the head space HS of the container 30 and the liquid L has reached an equilibrium state or is in a state sufficiently close to the equilibrium state, , based on the oxygen concentration in the container 30 (the oxygen concentration in the headspace HS of the container 30) in a state that has reached an equilibrium state or is sufficiently close to the equilibrium state, the dissolved oxygen amount of the liquid L contained in the container 30 is It is an inspection method to specify.
  • the inspection method of modification 17 includes an acquisition process and an identification process.
  • the inspection method of modification 17 further includes a determination step.
  • the oxygen concentration in the container 30 (oxygen in the headspace HS of the container 30,
  • the oxygen concentration in container 30 is measured by any test method that measures oxygen concentration.
  • the first oxygen concentration, which is the oxygen concentration in the container 30 at the first time, and the second oxygen concentration, which is the oxygen concentration in the container 30 at the second time are acquired.
  • the first time and the second time there is an interval of 1 minute or more and 5 minutes or less.
  • the first oxygen concentration and the second oxygen concentration when the movement of oxygen between the headspace HS of the container 30 and the liquid L is not in a state close to equilibrium due to the empty time of 1 minute or more. difference increases. This makes it easier to detect that the movement of oxygen between the headspace HS of the container 30 and the liquid L is not in a state close to equilibrium due to the difference between the first oxygen concentration and the second oxygen concentration. .
  • the time required for the inspection can be shortened by setting the vacant time to 5 minutes or less.
  • the obtaining step may include vibrating the container 30 at a time between the first time and the second time.
  • the container 30 may be vibrated by vibrating the entire liquid-filled combination container 10 ⁇ /b>L, or the container 30 may be vibrated inside the barrier container 40 .
  • the step of vibrating the container 30 the movement of oxygen between the headspace HS of the container 30 and the liquid L is close to equilibrium without increasing the time between the first time and the second time.
  • the difference between the first oxygen concentration and the second oxygen concentration in the absence of the state becomes large. This makes it easier to detect that the movement of oxygen between the headspace HS of the container 30 and the liquid L is not in a state close to equilibrium due to the difference between the first oxygen concentration and the second oxygen concentration. .
  • the oxygen concentration in the container 30 of the liquid-filled combination container 10L (the oxygen concentration in the headspace HS of the container 30) is measured, and the dissolved oxygen amount of the liquid L contained in the container 30 is based on the measured oxygen concentration. , it is not necessary to acquire the oxygen concentration in the container 30 at the first time in the acquisition step.
  • the step of vibrating the container 30, and the step of obtaining the second oxygen concentration which is the oxygen concentration in the container 30 at the second time after performing the step of vibrating the container 30. , may be performed.
  • the determination step to be described later is not performed, and in the specifying step to be described later, the oxygen saturation solubility in the liquid L contained in the container 30 is specified based on the second oxygen concentration, and the liquid is determined based on the specified oxygen saturation solubility.
  • the oxygen dissolution amount of L may be specified.
  • the acquisition step may include a step of determining whether the oxygen concentration in the barrier container 40 is below the target value.
  • the target value of the oxygen concentration in the barrier container 40 is such that the amount of oxygen dissolved in the liquid L in the container 30 is reduced to the target value, and the distance between the headspace HS of the container 30 and the liquid L is It can be defined as the concentration of oxygen in the headspace HS of the container 30 when oxygen migration has reached equilibrium.
  • the target value of the amount of oxygen dissolved in the liquid L in the container 30 can be set to a value that sufficiently suppresses the decomposition of the liquid L by oxygen according to the properties of the liquid L contained in the container 30. .
  • the method of determining whether the oxygen concentration in the barrier container 40 is equal to or less than the target value is not particularly limited.
  • the liquid-filled combination container 10L When the liquid-filled combination container 10L is provided with the oxygen detector 25, whether the oxygen concentration in the barrier container 40 is below the target value can be determined from the oxygen state in the barrier container 40 detected and displayed by the oxygen detector 25. You can judge.
  • the liquid-filled combination container 10L may have a feature that allows the oxygen concentration in the barrier container 40 to be measured. In such a case, as described in the third embodiment, by measuring the oxygen concentration in the barrier container 40, it is determined whether the oxygen concentration in the barrier container 40 is equal to or lower than the target value.
  • a fluorescent material 27 may be provided inside the barrier container 40 as shown in FIG.
  • the fluorescent material 27 is irradiated with light that causes the fluorescent material 27 to fluoresce, the fluorescence time or fluorescence intensity of the fluorescent material 27 is measured, and the oxygen content in the barrier container 40 is reduced based on the measured fluorescence time or fluorescence intensity. Concentration may be measured. Further, as shown in FIG. 25, laser light or LED light is irradiated so as to pass through the barrier container 40, the attenuation rate of the laser light or LED light is measured, and the barrier film is formed based on the measured attenuation rate. The oxygen concentration within the storage container 40 may be measured.
  • the step of determining whether the oxygen concentration in the barrier container 40 is equal to or less than the target value may be performed before the first time, may be performed between the first time and the second time, or may be performed after the second time. It may be performed after the time, or may be performed at the same time as the first time or the second time.
  • the second oxygen concentration is 100 times or more the measurement limit and 0.99 times or more and 1.01 times or less the first oxygen concentration, or the second oxygen concentration is the measurement limit or more and 100 times the measurement limit. and less than 0.9 times and 1.1 times or less of the first oxygen concentration, or the second oxygen concentration is less than the measurement limit and the first oxygen concentration is less than the measurement limit. is satisfied.
  • the condition it is considered that the change in the oxygen concentration in the headspace HS of the container 30 from the first time to the second time is small. Therefore, it can be determined that the movement of oxygen between the head space HS of the container 30 and the liquid L has reached an equilibrium state or is in a state sufficiently close to the equilibrium state.
  • the measurement limit is the measurement limit of the oxygen concentration measuring method used to acquire the first oxygen concentration and the second oxygen concentration in the acquisition step.
  • the measurement limit is, for example, 0.1% or more and 25% or less.
  • the case of measuring the oxygen concentration in the container 30 by the method comprising the attenuation rate measurement step described above is, for example, irradiating laser light or LED light, measuring the attenuation rate of the laser light or LED light, and based on the attenuation rate This is the case of measuring the oxygen concentration in the container 30 .
  • the measurement limit The value is, for example, 0.03% or more and 100% or less.
  • the case of measuring the oxygen concentration in the container 30 by the method including the fluorescence measurement step described above is, for example, irradiating the fluorescent material 27 with light that causes the fluorescent material 27 to fluoresce, and measuring the fluorescence time or fluorescence intensity of the fluorescent material 27. This is the case of measuring the oxygen concentration in the container 30 by
  • the second oxygen concentration is 100 times or more the measurement limit and 0.99 times or more and 1.01 times or less the first oxygen concentration, or the second oxygen concentration is the measurement limit or more and 100 times the measurement limit. less than and 0.9 to 1.1 times the first oxygen concentration, or the second oxygen concentration is less than the measurement limit and the first oxygen concentration is less than the measurement limit.
  • the identifying step determines that, as a result of the determining step, the movement of oxygen between the headspace HS of the container 30 and the liquid L has reached equilibrium or is sufficiently close to equilibrium. Do if judged.
  • the second oxygen concentration is 100 times or more the measurement limit and 0.99 times or more and 1.01 times or less the first oxygen concentration, or the second oxygen concentration is greater than or equal to the measurement limit. less than 100 times and 0.9 times or more and 1.1 times or less of the first oxygen concentration, or the second oxygen concentration is less than the measurement limit and the first oxygen concentration is less than the measurement limit. If it is determined that the condition is not satisfied, the steps from the obtaining step to the determining step may be repeated, and after it is determined that the condition is satisfied, the specifying step may be performed.
  • the specifying step is performed when the second oxygen concentration is 100 times or more the measurement limit and the first oxygen concentration is higher than the first oxygen concentration. 0.99 times or more and 1.01 times or less, or the second oxygen concentration is equal to or more than the measurement limit and less than 100 times the measurement limit and is 0.9 times or more and 1.1 times or less than the first oxygen concentration, Alternatively, it may be performed when the second oxygen concentration is below the measurement limit, the first oxygen concentration is below the measurement limit, and the oxygen concentration in the barrier container 40 is below the target value.
  • the oxygen saturation solubility in the liquid L contained in the container 30 is identified based on the second oxygen concentration, and the oxygen dissolution amount of the liquid L is identified based on the identified oxygen saturation solubility.
  • the oxygen saturation solubility in the liquid L contained in the container 30 is identified based on the second oxygen concentration, and the oxygen dissolution amount of the liquid L is identified based on the identified oxygen saturation solubility.
  • the oxygen saturation solubility in the liquid L contained in the container 30 is specified based on the oxygen concentration in the container 30 (oxygen concentration in the headspace HS of the container 30) described in each embodiment and each modification. , a method of specifying the oxygen dissolution amount of the liquid L based on the specified oxygen saturation solubility can be applied.
  • the amount of dissolved oxygen in the liquid L is the same as that in the container 30 when the movement of oxygen between the headspace HS of the container 30 and the liquid L has reached or is sufficiently close to an equilibrium state. It can be calculated based on the oxygen concentration inside (the oxygen concentration in the headspace HS of the container 30). However, in the liquid-filled combination container 10L, it is also assumed that the movement of oxygen between the headspace HS of the container 30 and the liquid L has not reached a state close to equilibrium. For example, it is assumed that a state close to the equilibrium state has not been reached because the speed at which oxygen in the liquid L moves to the headspace HS is slow.
  • the dissolved oxygen amount of the liquid L is calculated based on the oxygen concentration in the headspace HS of the container 30, the dissolved oxygen amount is calculated to be smaller than the actual value. It is also assumed that oxygen may flow into the headspace HS of the container 30 from the outside of the barrier container 40 through the inside of the barrier container 40 due to deterioration of the barrier container 40 or the like. In this case, if the dissolved oxygen amount of the liquid L is calculated based on the oxygen concentration in the headspace HS of the container 30, the calculated dissolved oxygen amount is larger than the actual value.
  • the specifying step is performed such that the second oxygen concentration is 100 times or more the measurement limit and 0.99 times or more and 1.01 times or less the first oxygen concentration, or 2
  • the oxygen concentration is greater than or equal to the measurement limit and less than 100 times the measurement limit and is 0.9 times or more and 1.1 times or less than the first oxygen concentration, or the second oxygen concentration is less than the measurement limit and the first oxygen
  • the specific process is performed when the movement of oxygen between the headspace HS of the container 30 and the liquid L reaches or is sufficiently close to an equilibrium state.
  • the oxygen saturation solubility in L and the amount of dissolved oxygen in liquid L can be specified with high accuracy.
  • the obtaining step includes a step of determining whether the oxygen concentration in the barrier container 40 is equal to or lower than the target value, and the specifying step is performed when the oxygen concentration in the barrier container 40 is equal to or lower than the target value.
  • the specific step can be performed after confirming that oxygen does not flow into the headspace HS of the container 30 from the outside of the barrier container 40 .
  • the saturation solubility of oxygen in the liquid L and the amount of dissolved oxygen in the liquid L can be specified with high accuracy.
  • Modification 18 The inspection method of Modified Example 18 calculates the rate of decrease in the amount of dissolved oxygen in the liquid L contained in the container 30, determines whether the rate of decrease is equal to or greater than a target value, and This inspection method determines whether the concentration is equal to or less than a target value.
  • the inspection method of Modification 18 includes a step of acquiring the oxygen concentration in the container 30 at the first measurement time and the oxygen concentration in the container 30 at the second measurement time after the first measurement time, A step of specifying a first dissolved oxygen amount that is the dissolved oxygen amount of L; a step of specifying a second dissolved oxygen amount that is the dissolved oxygen amount of the liquid L at the second measurement time; a step of calculating the rate of decrease of the amount of dissolved oxygen in the liquid L based on the amount of dissolved oxygen and determining whether the rate of decrease is equal to or greater than a target value; and a step of determining
  • a step of acquiring the oxygen concentration in the container 30 at the first measurement time and the oxygen concentration in the container 30 at the second measurement time after the first measurement time is performed.
  • the inside of the container 30 is measured by any of the inspection methods for measuring the oxygen concentration in the container 30 (the oxygen concentration in the headspace HS of the container 30) described in each of the above-described embodiments and modifications. Measure the oxygen concentration of
  • the oxygen concentration in the container 30 at the first measurement time and the oxygen concentration in the container 30 at the second measurement time are obtained.
  • the oxygen saturation solubility in the liquid L contained in the container 30 at the first measurement time is specified, and based on the specified oxygen saturation solubility, the first A step of specifying a first dissolved oxygen amount, which is the dissolved oxygen amount of the liquid L at the measurement time, is performed. Further, based on the oxygen concentration in the container 30 at the second measurement time, the oxygen saturation solubility in the liquid L contained in the container 30 at the second measurement time is specified, and the second measurement is performed based on the specified oxygen saturation solubility. A step of specifying a second oxygen dissolution amount, which is the oxygen dissolution amount of the liquid L at the time, is performed.
  • the step of specifying the first dissolution amount of oxygen and the step of specifying the second dissolution amount of oxygen are the oxygen concentration in the container 30 (the By applying a method of specifying the oxygen saturation solubility in the liquid L contained in the container 30 based on the oxygen concentration) and specifying the oxygen dissolution amount of the liquid L based on the specified oxygen saturation solubility can.
  • a step of calculating the decreasing rate of the dissolved oxygen amount of the liquid L based on the first dissolved oxygen amount and the second dissolved oxygen amount and determining whether the decreasing rate is equal to or higher than the target value is performed.
  • the first dissolved oxygen amount which is the amount of oxygen dissolved in the liquid L at the first measurement time
  • the second dissolved oxygen amount which is the amount of oxygen dissolved in the liquid L at the second measurement time after the first measurement time. and have been obtained. Therefore, the decrease rate of the dissolved oxygen amount of the liquid L can be calculated from the elapsed time from the first measurement time to the second measurement time and the values of the first dissolved oxygen amount and the second dissolved oxygen amount.
  • the target value of the rate of decrease it is possible to set a value of the rate of decrease at which the amount of oxygen dissolved in the liquid L can be expected to decrease below the target value after the target time has elapsed.
  • the target time it is possible to set the time required from the inspection of the liquid-filled combination container 10L until the liquid-filled combination container 10L is shipped and delivered to the user.
  • the target value of the oxygen dissolution amount of the liquid L can be set to a value that sufficiently suppresses the decomposition of the liquid L by oxygen according to the properties of the liquid L contained in the container 30 .
  • a step of determining whether the oxygen concentration in the barrier container 40 is equal to or less than the target value is performed.
  • the target value of the oxygen concentration in the barrier container 40 is such that the amount of dissolved oxygen in the liquid L in the container 30 is reduced to the target value and oxygen is transferred between the headspace HS of the container 30 and the liquid L. can be determined to be the oxygen concentration in the headspace HS of the container 30 when the is at equilibrium.
  • the target value of the amount of oxygen dissolved in the liquid L in the container 30 can be set to a value that sufficiently suppresses the decomposition of the liquid L by oxygen according to the properties of the liquid L contained in the container 30. .
  • the method of determining whether the oxygen concentration in the barrier container 40 is equal to or less than the target value is not particularly limited.
  • the liquid-filled combination container 10L is provided with the oxygen detector 25, whether the oxygen concentration in the barrier container 40 is below the target value can be determined from the oxygen state in the barrier container 40 detected and displayed by the oxygen detector 25. You can judge.
  • the liquid-filled combination container 10L may have a feature that allows the oxygen concentration in the barrier container 40 to be measured. In such a case, as described in the third embodiment, by measuring the oxygen concentration in the barrier container 40, it is determined whether the oxygen concentration in the barrier container 40 is equal to or lower than the target value.
  • a fluorescent material 27 may be provided inside the barrier container 40 as shown in FIG.
  • the fluorescent material 27 is irradiated with light that causes the fluorescent material 27 to fluoresce, the fluorescence time or fluorescence intensity of the fluorescent material 27 is measured, and the oxygen content in the barrier container 40 is reduced based on the measured fluorescence time or fluorescence intensity. Concentration may be measured. Further, as shown in FIG. 25, laser light or LED light is irradiated so as to pass through the barrier container 40, the attenuation rate of the laser light or LED light is measured, and the barrier film is formed based on the measured attenuation rate. The oxygen concentration within the storage container 40 may be measured.
  • the oxygen scavenger 21 contained in the barrier container 40 reduces the oxygen concentration inside the barrier container 40, and correspondingly, the oxygen in the headspace HS of the container 30 is reduced.
  • the concentration decreases, and the amount of dissolved oxygen in the liquid L in the container 30 decreases accordingly.
  • the liquid-filled combination container 10L is shipped after it is confirmed that the amount of dissolved oxygen in the liquid L in the container 30 has fallen below the target value.
  • the rate of decrease in the amount of dissolved oxygen in the liquid L is calculated, and it is determined whether the rate of decrease is equal to or greater than the target value. It can be determined whether the oxygen dissolution amount of is expected to decrease below the target value. Thus, for example, it can be determined whether the dissolved oxygen amount in the liquid L can be expected to decrease below the target value before the liquid-filled combination container 10L is shipped and delivered to the user.
  • the liquid-filled combination container 10L can be shipped. As a result, it is possible to suppress the lengthening of the period from the manufacture of the liquid-filled combination container 10L to the shipment, and eliminate the need for a space for storing the liquid-filled combination container 10L for a long period of time.
  • the step of determining whether the oxygen concentration in the barrier container 40 is equal to or less than the target value is performed.
  • the target value of the oxygen concentration in the barrier container 40 is such that the amount of dissolved oxygen in the liquid L in the container 30 is reduced to the target value and oxygen is transferred between the headspace HS of the container 30 and the liquid L. is determined to be the oxygen concentration in the headspace HS of the container 30 when is in equilibrium.
  • the concentration decreases, and the amount of dissolved oxygen in the liquid L in the container 30 decreases accordingly.
  • the rate of decrease in the amount of dissolved oxygen in the liquid L is equal to or higher than the target value
  • the oxygen in the liquid L in the container 30 will be reduced before the target time elapses.
  • the dissolution amount may not decrease to the target value.
  • the seventh embodiment relates to an inspection method for the liquid-filled combination container 10L.
  • the inspection method of the seventh embodiment includes a container 30 containing a liquid L in a container 31 and having oxygen permeability, a barrier container 40 containing the container 30 and having an oxygen barrier property, and a barrier container 40 having an oxygen barrier property.
  • a method for inspecting a liquid-filled combination container 10L comprising at least one oxygen-reactive agent 20 capable of reacting with oxygen in 40 and a fluorescent material 27 having different fluorescent time or fluorescent intensity depending on the ambient oxygen concentration.
  • the fluorescent material 27 is provided on the inner surface 30a of the housing portion 31 of the container 30 at the fluorescent material installation position 39 away from the contact area 31a that contacts the liquid L. As shown in FIG.
  • the container 30 has optical transparency at least at the fluorescent material installation position 39 .
  • the barrier container 40 has a light transmission position 40b having light transmission properties.
  • the inspection method of the seventh embodiment can be widely applied to the liquid-filled combination container 10L described above.
  • a method of inspecting the liquid-filled combination container 10L of the fifth embodiment will be described.
  • the inspection method of the seventh embodiment includes an arrangement process, a fluorescence measurement process, and a measurement process.
  • the oxygen reactive agent 20 is arranged so as not to be positioned between the fluorescent material installation position 39 and the light transmitting position 40b.
  • the fluorescence measurement step the light that causes the fluorescent material 27 to fluoresce is transmitted through the light transmission position 40b of the barrier container 40 and the fluorescent material installation position 39 of the container 30, and the fluorescent material 27 is irradiated with the light to detect the fluorescence of the fluorescent material 27. Measure time or fluorescence intensity.
  • the oxygen concentration in the container 30 is measured based on the fluorescence time or fluorescence intensity of the fluorescent material 27 measured in the fluorescence measurement process.
  • the oxygen reactive agent 20 is arranged so as not to be positioned between the fluorescent material installation position 39 and the light transmission position 40b.
  • the oxygen reactant 20 is arranged so as not to be positioned between the fluorescent material installation position 39 and the light transmission position 40b. This includes maintaining the position of the oxygen reactant 20 unchanged, ensuring that it is not positioned between the permeate position 40b.
  • the oxygen reactant 20 is held in the holding space 58 so as not to be positioned between the fluorescent material installation position 39 and the light transmitting position 40b.
  • the oxygen reactant 20 is held in the holding space 58 so as not to be positioned between the fluorescent material installation position 39 and the light transmission position 40b. to keep the position of the oxygen reactant 20 unchanged.
  • the oxygen reactant 20 is arranged so as not to be positioned between the fluorescent material installation position 39 and the light transmission position 40b in the arrangement step. to change
  • the light that causes the fluorescent material 27 to fluoresce is transmitted through the light transmission position 40b of the barrier container 40 and the fluorescent material installation position 39 of the container 30, and the fluorescent material 27 is irradiated with the light to detect the fluorescence of the fluorescent material 27. Measure time or fluorescence intensity.
  • the description regarding the fluorescence measurement step of the inspection method for the liquid-filled combination container 10L of the first embodiment also applies to the fluorescence measurement step of the inspection method of the seventh embodiment.
  • the oxygen concentration in the container 30 is measured based on the fluorescence time or fluorescence intensity of the fluorescent material 27 measured in the fluorescence measurement process.
  • the description of the measurement process of the inspection method for the liquid-filled combination container 10L of the first embodiment also applies to the attenuation rate measurement process of the inspection method of the seventh embodiment.
  • the oxygen concentration in the container 30 of the liquid-filled combination container 10L can also be measured by the inspection method of the seventh embodiment.
  • 10L combination container containing liquid
  • 30L liquid-filled container

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  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Examining Or Testing Airtightness (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
PCT/JP2022/048666 2021-12-28 2022-12-28 液体入り組合せ容器、検査方法及び液体入り組合せ容器の製造方法 Ceased WO2023127967A1 (ja)

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CA3253697A CA3253697A1 (en) 2021-12-28 2022-12-28 Liquid-filled combination container, inspection method, and manufacturing method for liquid-filled combination container
EP22916189.8A EP4458725A4 (en) 2021-12-28 2022-12-28 Liquid-filled coverall container, test method and method for producing a liquid-filled coverall container
CN202280086504.2A CN118488920A (zh) 2021-12-28 2022-12-28 装液组合容器、检查方法以及装液组合容器的制造方法
US18/724,849 US20250058955A1 (en) 2021-12-28 2022-12-28 Liquid-filled combination container, inspection method, and manufacturing method for liquid-filled combination container
JP2023571233A JP7486064B2 (ja) 2021-12-28 2022-12-28 液体入り組合せ容器、検査方法及び液体入り組合せ容器の製造方法
JP2024074477A JP2024109625A (ja) 2021-12-28 2024-05-01 液体入り組合せ容器、検査方法及び液体入り組合せ容器の製造方法
JP2025265807A JP2026062747A (ja) 2021-12-28 2025-12-18 液体入り組合せ容器、検査方法及び液体入り組合せ容器の製造方法

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EP4458725A1 (en) 2024-11-06
US20250058955A1 (en) 2025-02-20
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