WO2023120900A1 - Composition cosmétique pour réduire la chute des cheveux ou favoriser la pousse des cheveux comprenant un promoteur de croissance cellulaire en tant que principe actif - Google Patents
Composition cosmétique pour réduire la chute des cheveux ou favoriser la pousse des cheveux comprenant un promoteur de croissance cellulaire en tant que principe actif Download PDFInfo
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- WO2023120900A1 WO2023120900A1 PCT/KR2022/014997 KR2022014997W WO2023120900A1 WO 2023120900 A1 WO2023120900 A1 WO 2023120900A1 KR 2022014997 W KR2022014997 W KR 2022014997W WO 2023120900 A1 WO2023120900 A1 WO 2023120900A1
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- WIPO (PCT)
- Prior art keywords
- hair loss
- active ingredient
- cosmetic composition
- growth factor
- dermal papilla
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- 229920002647 polyamide Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- BOLDJAUMGUJJKM-LSDHHAIUSA-N renifolin D Natural products CC(=C)[C@@H]1Cc2c(O)c(O)ccc2[C@H]1CC(=O)c3ccc(O)cc3O BOLDJAUMGUJJKM-LSDHHAIUSA-N 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 229940071089 sarcosinate Drugs 0.000 description 1
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000036299 sexual function Effects 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000037351 starvation Effects 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229940104261 taurate Drugs 0.000 description 1
- 201000001297 telogen effluvium Diseases 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 208000002271 trichotillomania Diseases 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 210000003556 vascular endothelial cell Anatomy 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
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- 239000001993 wax Substances 0.000 description 1
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
Definitions
- the present invention provides a cosmetic composition for improving hair loss or promoting hair growth containing CM50 as an active ingredient.
- CM50 according to the present invention has an excellent effect of increasing the proliferative ability and collagen synthesis ability of dermal papilla cells and improving the hair loss of hair loss patients, it is expected to be useful as a composition for improving hair loss or promoting hair growth without side effects.
- Figure 3 is the result of analyzing the collagen synthesis ability of dermal papilla cells by the CM50 treatment of the present invention.
- Control is a control group that is not treated with anything.
- the CM50 is preferably 1 to 110 ng/ml of epidermal growth factor (EGF) and 18 to 110 ng/ml of basic fibroblast growth It may consist of basic fibroblast growth factor (bFGF), 3 to 50 mM of ascorbic acid and 90 to 110 mM of N-acetyl-L-glutamine (NAG), , More preferably, 1 to 3 ng/ml of epidermal growth factor (EGF), 90 to 110 ng/ml of basic fibroblast growth factor (bFGF), and 30 to 50 mM of It may consist of ascorbic acid and 90 to 110 mM of N-acetyl-L-glutamine (NAG), most preferably 2 ng/ml of epidermal growth factor, It may consist of 100 ng/ml basic fibroblast growth factor, 40 mM ascorbic acid, and 100 mM N-acetyl-L-glutamine, but is not
- the CM50 may be included in an amount of 1 to 10% by weight based on the total weight of the composition, but is not limited thereto.
- the cosmetic composition for improving hair loss or promoting hair growth of the present invention can be used to prevent, treat, or improve alopecia, and the hair loss includes alopecia areata, hereditary androgenetic alopecia, telogen effluvium, Traumatic alopecia, Trichotillomania, Pressure alopecia, anagen alopecia, pityriasis alopecia, syphilitic alopecia (Alopecia syphilitica), seborrheic alopecia (Alopecia seborrheica), symptomatic alopecia, scarring alopecia, or congenital alopecia can be chosen
- the cosmetic composition for improving hair loss or promoting hair growth is cream, softening lotion, nutrient lotion, pack, essence, hair tonic, shampoo, rinse, hair conditioner, hair treatment, gel , Skin Lotion, Skin Softener, Skin Toner, Astringent, Milk Lotion, Moisture Lotion, Nutrition Lotion, Massage Cream, Nutrition Cream, Moisture Cream, Hand Cream, Foundation, Nutrition Essence, Sunscreen, Soap, Cleansing Foam, Cleansing Lotion, Cleansing It may have any one formulation selected from the group consisting of cream, body lotion and body cleanser, but is not limited thereto.
- the cosmetic composition composed of each of these formulations may contain various bases and additives necessary and appropriate for formulation of the formulation, and the types and amounts of these components can be easily selected by those skilled in the art.
- lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component, and in particular, in the case of a spray, additional chlorofluorohydro propellants such as carbon, propane-butane or dimethyl ether.
- a solvent, solvating agent or emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene fatty acid esters of glycol, 1,3-butylglycol oil, glycerol aliphatic esters, polyethylene glycol or sorbitan.
- the present invention also provides an external skin preparation for improving hair loss or promoting hair growth, containing CM50 as an active ingredient.
- the external skin preparation may be prepared in the form of a cream, gel, patch, ointment, warning agent, lotion, liquid, emulsion, powder or spray, but is not limited thereto.
- the present invention also provides a method for preventing or treating hair loss comprising applying the cosmetic composition to the hair loss area.
- the CM50 may be added to various commercially known media for culturing dermal papilla cells, but is not limited thereto.
- Example 1 Evaluation of optimal concentration of cell growth promoting substances
- CM50 according to the present invention is treated with dermal papilla cells cultured in three dimensions using biocompatible microcarriers, the ability to synthesize collagen is remarkably increased, making hair stronger and helping to prevent hair loss. It was found that
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Birds (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Dermatology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Cosmetics (AREA)
Abstract
La présente invention concerne une composition cosmétique pour réduire la chute des cheveux ou favoriser la pousse des cheveux, comprenant un promoteur de croissance cellulaire en tant que principe actif. Le promoteur de croissance cellulaire en tant que principe actif de la présente invention est le CM50 constitué de 1 à 110 ng/ml de facteur de croissance épidermique (EGF), de 18 à 110 ng/ml de facteur de croissance fibroblastique basique (bFGF), de 3 à 50 mM d'acide ascorbique et de 90 à 110 mM de N-acétyl-L-glutamine (NAG), ayant un excellent effet d'augmentation de la capacité de prolifération de cellules de papille dermique et de performance de synthèse de collagène et d'amélioration de la chute de cheveux chez un patient ayant une chute de cheveux. Par conséquent, il est prévu que le promoteur de croissance cellulaire puisse être utilisé utilement dans une composition pour améliorer la chute des cheveux et favoriser la croissance des cheveux sans effets secondaires.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020210182945A KR102376630B1 (ko) | 2021-12-20 | 2021-12-20 | 세포성장촉진 물질을 유효성분으로 함유하는 탈모 개선 또는 발모 촉진용 화장료 조성물 |
| KR10-2021-0182945 | 2021-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2023120900A1 true WO2023120900A1 (fr) | 2023-06-29 |
Family
ID=80936802
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/KR2022/014997 WO2023120900A1 (fr) | 2021-12-20 | 2022-10-05 | Composition cosmétique pour réduire la chute des cheveux ou favoriser la pousse des cheveux comprenant un promoteur de croissance cellulaire en tant que principe actif |
Country Status (2)
| Country | Link |
|---|---|
| KR (1) | KR102376630B1 (fr) |
| WO (1) | WO2023120900A1 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102376630B1 (ko) * | 2021-12-20 | 2022-03-18 | 이효종 | 세포성장촉진 물질을 유효성분으로 함유하는 탈모 개선 또는 발모 촉진용 화장료 조성물 |
| JP7556627B1 (ja) | 2024-06-18 | 2024-09-26 | 株式会社再生医学研究所 | 育毛効果、白髪改善効果、及びしわ改善効果を有する組成物およびその製造方法。 |
Citations (6)
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|---|---|---|---|---|
| KR20120093714A (ko) * | 2011-02-15 | 2012-08-23 | (주)다미화학 | Ｎ-아세틸-ｌ-글루타민을 유효성분으로 포함하는 화장료 조성물 |
| KR20180041645A (ko) * | 2018-04-11 | 2018-04-24 | 이효종 | 성장인자 및 아미노산을 포함하는 것을 특징으로 하는 발모 촉진제 |
| KR101951283B1 (ko) * | 2017-11-13 | 2019-02-22 | 양미경 | 탈모의 예방 또는 치료용, 또는 발모 또는 육모 촉진용 약학 또는 화장료 조성물 |
| KR20190115286A (ko) * | 2018-04-02 | 2019-10-11 | 양미경 | 탈모의 예방 또는 치료용, 또는 발모 또는 육모 촉진용 약학 또는 화장료 조성물 |
| KR102124272B1 (ko) * | 2018-12-10 | 2020-06-18 | 연세대학교 산학협력단 | Hb-egf를 유효성분으로 포함하는 지방줄기세포의 발모능 증진용 조성물 |
| KR102376630B1 (ko) * | 2021-12-20 | 2022-03-18 | 이효종 | 세포성장촉진 물질을 유효성분으로 함유하는 탈모 개선 또는 발모 촉진용 화장료 조성물 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3424930B2 (ja) * | 1992-12-09 | 2003-07-07 | 協和醗酵工業株式会社 | Ｎ−アシルグルタミン誘導体 |
| KR970009457B1 (ko) * | 1994-08-11 | 1997-06-13 | 대우전자 주식회사 | 캡션방송채널 자동디스플레이장치의 파형정형회로 |
| US9820933B2 (en) * | 2013-04-19 | 2017-11-21 | Korea University Research And Business Foundation | Composition for stimulating hair growth or preventing hair loss which includes extract neural stem cell and method for producing same |
| CN107106459B (zh) * | 2014-11-17 | 2021-06-22 | 韩国比奥科斯全球公司 | 包含细胞培养基、表皮生长因子和牛血清白蛋白的用于改善皮肤状态的药物组合物 |
| KR101779932B1 (ko) * | 2015-09-15 | 2017-09-21 | 주식회사 스템랩 | 나노그(Nanog)를 도입한 양수 내 태아 유래 중간엽 줄기세포를 이용한 육모 촉진용 조성물의 제조방법 |
| KR20200025210A (ko) * | 2018-08-29 | 2020-03-10 | 주식회사 스템모어 | 모유두 세포의 배양용 조성물 및 이를 이용한 모유두 세포의 배양 방법 |
-
2021
- 2021-12-20 KR KR1020210182945A patent/KR102376630B1/ko active IP Right Grant
-
2022
- 2022-10-05 WO PCT/KR2022/014997 patent/WO2023120900A1/fr unknown
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20120093714A (ko) * | 2011-02-15 | 2012-08-23 | (주)다미화학 | Ｎ-아세틸-ｌ-글루타민을 유효성분으로 포함하는 화장료 조성물 |
| KR101951283B1 (ko) * | 2017-11-13 | 2019-02-22 | 양미경 | 탈모의 예방 또는 치료용, 또는 발모 또는 육모 촉진용 약학 또는 화장료 조성물 |
| KR20190115286A (ko) * | 2018-04-02 | 2019-10-11 | 양미경 | 탈모의 예방 또는 치료용, 또는 발모 또는 육모 촉진용 약학 또는 화장료 조성물 |
| KR20180041645A (ko) * | 2018-04-11 | 2018-04-24 | 이효종 | 성장인자 및 아미노산을 포함하는 것을 특징으로 하는 발모 촉진제 |
| KR102124272B1 (ko) * | 2018-12-10 | 2020-06-18 | 연세대학교 산학협력단 | Hb-egf를 유효성분으로 포함하는 지방줄기세포의 발모능 증진용 조성물 |
| KR102376630B1 (ko) * | 2021-12-20 | 2022-03-18 | 이효종 | 세포성장촉진 물질을 유효성분으로 함유하는 탈모 개선 또는 발모 촉진용 화장료 조성물 |
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| KR102376630B1 (ko) | 2022-03-18 |
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