WO2022226857A1 - Pansement humide destiné à la protection de couleur de tatouage et son procédé d'utilisation - Google Patents
Pansement humide destiné à la protection de couleur de tatouage et son procédé d'utilisation Download PDFInfo
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- WO2022226857A1 WO2022226857A1 PCT/CN2021/090790 CN2021090790W WO2022226857A1 WO 2022226857 A1 WO2022226857 A1 WO 2022226857A1 CN 2021090790 W CN2021090790 W CN 2021090790W WO 2022226857 A1 WO2022226857 A1 WO 2022226857A1
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- WO
- WIPO (PCT)
- Prior art keywords
- hydrogel
- silane
- wet dressing
- factor
- tattoo
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
Definitions
- the present invention is a wet dressing with moisturizing and color protection, which is used for repairing damaged skin after fresh tattoo and protecting the color of tattoo ink.
- the wet dressing has the characteristics of high water content and low absorption capacity of aqueous solution. Therefore, the wet dressing can provide medical-grade repair for damaged skin after tattooing, protect and isolate, maintain moisturization, and assist the deposition of tattoo ink in the skin, so as to enhance the artistic beauty of tattooing.
- the wound of the tattoo is an open wound. If it is not isolated, if it comes into contact with water (such as bathing), contact with bacteria in the air or clothing, it may cause the wound to become infected and inflamed, causing the tattoo ink to fade. If the wound is not protected by an isolation layer, the scab will easily adhere to the quilt, bed, towel or clothes, tearing off the scab, and even causing the tattoo wound to open again, causing wound infection and ink fading. In addition, the tattooer is easy to scratch the scab because of the dryness and itching of the scab, which will also cause the wound to become infected and the ink to fade.
- plastic such as plastic wrap
- plastic wrap is airtight and does not have medical quality, and it is easy to cause wound ulceration or skin irritation due to airtightness and stuffy & wet, and it is easy to fall off. Therefore, plastic wrap can only be used as an auxiliary barrier for a few hours after fresh tattooing, after which the plastic wrap must be removed.
- US Patent Publication No. US20140200196A1 discloses that alginate hydrogel combined with mineral-containing spray solution forms a transparent film layer for wound isolation, hemostasis and repair.
- the hydrogel of this patent is gel-like, and its structural force is insufficient to cushion the physical impact and friction of the wound site.
- the moisture permeability of the outer layer film formed by the alginate hydrogel in this patent is too high, and needs to be maintained by wound exudate to maintain a moist state. The moisture of the wound will become dry due to volatilization.
- the hydrogel can be easily removed due to drying, it loses the necessary factors for wound repair to keep moist, and may reverse the absorption of tattoo ink, resulting in the loss of tattoo ink.
- the alginate hydrogel in this patent has no waterproof effect, so that the wound cannot touch water after fresh tattooing, such as bathing, cleaning, going out in rainy days, etc., the swelling of the hydrogel will not only cause the hydrogel In addition to the shedding of the protective layer, it is also easy to cause the wound to be infected by microorganisms due to contact with water pollution sources. Due to the lack of sufficient adhesion, the patient must avoid the friction between the hydrogel protective layer at the wound and the clothing, and should not rub or pat the wound when itching, which will cause unnecessary pain and inconvenience to the tattooist.
- the patent involves two steps, the first step is to apply a thin layer of hydrogel first, and the second step is to spray a mineral-containing spray solution at a specific distance, so that the spray condenses to form a film on the surface of the hydrogel, and the spray
- the amount will also affect its structure and thickness, which shows that its use process is complicated and troublesome.
- US Patent Publication No. US20170042772A1 discloses that hydrogel patches and skin patches can be used for post-treatment after tattooing.
- the hydrogel patches described in this patent are not necessarily capable of adsorbing aqueous solutions (eg wound exudate).
- the hydrogel of this patent is formed by bonding with an adhesive and/or a thickening agent, rather than a three-dimensional network cross-linked polymerized structure, so it may dissolve due to water absorption and swelling.
- the patch of the patent contains a variety of ingredients (eg, gelling agent, thickening agent, emulsifier, preservative, anti-inflammatory agent, soothing agent, cooling agent and/or analgesic, etc.), and the main uses are Anti-inflammatory, soothing and antiseptic, the patent aims to change the dosage form of anti-inflammatory and soothing lotion or ointment into a patch form, and specifies that these ingredients will not affect the tattoo ink, but these ingredients are irritating and non-beneficial to wound healing and repair or harmful.
- ingredients eg, gelling agent, thickening agent, emulsifier, preservative, anti-inflammatory agent, soothing agent, cooling agent and/or analgesic, etc.
- Wound repair is a complex series of processes that the body initiates upon injury.
- the first stage "inflammation,” requires blood to flow to the wound area, delivering substances such as factors, proteins, and clotting components needed for healing, while the immune system resists and engulfs bacteria, foreign bodies, and debris in the wound.
- the proliferative phase new capillaries proliferate in the wound area, delivering more collagen, and the proliferative granulation tissue is deposited on the wound surface to provide the basic structure, and epidermal cells move and proliferate from the periphery of the wound to the inside to close the wound.
- the third stage of “maturity/remodeling” after the wound heals, the excess capillaries degenerate and atrophy, the collagen tissue elongates and aligns neatly, and the scar becomes lighter.
- the water absorption of general hydrogel dressings for wound treatment is too strong.
- the water absorption of the hydrogel dressing disclosed in US Patent Application No. 11720912 is 15 g/g. If a hydrogel dressing that is too absorbent is used on a tattoo, it may absorb too much tattoo ink, thereby affecting the rendering effect of the tattoo color.
- a tattoo wound is different from a normal wound, in that a tattoo uses a fine needle to pierce the epidermis, creating micro-perforations in the skin and depositing ink in the dermis beneath the epidermis to form a permanent pattern and color.
- the dermis contains nerve endings, sweat, sebaceous glands, blood and lymphatic vessels, and is a sensitive connective tissue layer of the skin. When a tattoo needle penetrates the dermis, the damaged tissue will trigger an inflammatory response, resulting in a small amount of blood and exudate.
- the present invention provides a waterproof and breathable wet dressing, which can be attached to the damaged and/or adjacent surrounding skin of the fresh tattooed part to isolate the stimulation or pollution of the external environment; and can pass the moisture or wound exudate of the dressing itself As well as the biological inertness and chemical stability of the dressing, the tattoo-damaged skin is kept in a moist microenvironment, in order to quickly pass the inflammatory period, promote wound healing, and maintain the artistic beauty of the tattoo pattern.
- An embodiment of the wet dressing of the present invention is a solid sheet-like dressing, and the solid sheet-like dressing comprises a hydrogel dressing.
- the sheet thickness of the hydrogel dressing is 0.02 to 5 mm.
- the sheet thickness of the hydrogel dressing is 0.05 to 3 mm.
- the sheet-like thickness of the hydrogel dressing is 0.1 to 2 mm.
- the present invention provides a wet dressing, which comprises a hydrogel (Hydrogel), wherein the water content of the hydrogel is greater than 50% by weight, and the aqueous solution absorption capacity is not greater than 5 g/g.
- a hydrogel Hydrogel
- the hydrogel has an attachment surface for attaching to the tattooed area and/or its surrounding area on the skin of an individual.
- the hydrogel is breathable.
- the wet dressing further comprises a sheet adhered to the hydrogel.
- the sheet has a two-sided structure, one of which is an adhesive surface, and the adhesive surface is bonded to the non-adhering surface of the hydrogel.
- the surface area of the adhesive surface of the sheet is greater than the surface area of the hydrogel. Since the hydrogel is non-adhesive, the adhesive surface of the sheet will have an additional attachment area outside the hydrogel, which is used as a secondary dressing to make the non-adhesive hydrogel adhere to the tattoo on the skin area.
- the sheet has the function of waterproof and breathable.
- the sheet is made of polyurethane (Polyurethane; PU).
- the polyurethane sheet of the present invention is composed of a polyurethane material with good biocompatibility, blood compatibility, flexibility, antibacterial property and adhesiveness. Therefore, the sheet of the present invention can be waterproof, transparent and breathable; thereby, not only can prevent water or bacteria from entering the wet dressing, but also maintain good breathability.
- the peel force of the sheet is 50 to 1,200 g/25mm. In a preferred embodiment, the peel force of the sheet is 100 to 1,000 g/25mm. In a more preferred embodiment, the peel force of the sheet is 200 to 800 g/25mm.
- the wet dressing provided by the present invention has appropriate waterproof, breathable and moisturizing properties, and can maintain the damaged skin after tattooing in a moist microenvironment through the moisture of the hydrogel itself or wound exudate, without being too dry or humid, Assist the damaged skin after tattooing to quickly pass through the inflammatory period, and enter the repair and proliferation period to accelerate wound healing, reduce the damage of the ink in the dermis layer of the skin by inflammatory substances, or the ink dissipates through the micro-perforation of the skin and fades.
- the wet dressing of the present invention does not need to be too strong in absorbing aqueous solution, thereby preventing ink from being absorbed and dissipated by the highly absorbent dressing through the capillary action of the micro-perforations. Therefore, the wet dressing of the present invention not only meets the needs of accelerating wound healing, but also takes into account the artistic beauty of the tattoo pattern.
- the aqueous solution absorption capacity of the hydrogel is not greater than 3 g/g. In a more preferred embodiment, the aqueous solution absorption capacity of the hydrogel is not greater than 2 g/g.
- the moisture permeability (Moisture Permeability) of the wet dressing is 200 to 3,500 g/M2/24Hr. In a preferred embodiment, the moisture permeability of the wet dressing is 300 to 3,000 g/M2/24Hr. In a more preferred embodiment, the moisture permeability of the wet dressing is 400 to 2,500 g/M2/24Hr.
- the hydrostatic pressure (waterproof performance) of the wet dressing is above 0.8M. In a preferred embodiment, the hydrostatic pressure of the wet dressing is above 1.2M. In a more preferred embodiment, the hydrostatic pressure of the wet dressing is above 1.5M.
- the hydrogel of the present invention is polymerized by the cross-linking of polymerizable polyunsaturated monomers and/or polymerizable polymers through heat, light, radiation irradiation or other means, and finally forms a solid hydrophilic structure with a three-dimensional network structure.
- sexual polymers In a specific embodiment, the hydrogel is formed by the reaction polymerization of a plurality of reactants; wherein the plurality of reactants include polymerizable monomers and/or polymers, silane-functionalized polyethylene glycols, or the like. derivatives, and cross-linking agents.
- the polymerizable monomer and/or polymer has an amphiphile and/or a hydrophilic group.
- amphiphilic group refers to a molecule having both hydrophilic and hydrophobic groups, wherein the hydrophilic group may be a charged or polar hydroxyl, aldehyde, carboxyl and/or Amino group, the hydrophobic group can be a non-polar hydrocarbon group and/or ester group.
- the "polymerizable monomer and/or polymer with an amphiphilic group” includes, but is not limited to, ⁇ -hydroxyethyl methacrylate (HEMA) or its derivatives, methacrylamide or Its derivatives, glycerol methacrylate or its derivatives, 2-hydroxyethylmethacrylamide or its derivatives, polyethylene glycol methacrylate or its derivatives, butyl methacrylate or its derivatives compound, ethylene glycol dimethacrylate or a derivative thereof, or a combination thereof.
- HEMA ⁇ -hydroxyethyl methacrylate
- methacrylamide or Its derivatives methacrylamide or Its derivatives
- 2-hydroxyethylmethacrylamide or its derivatives 2-hydroxyethylmethacrylamide or its derivatives
- polyethylene glycol methacrylate or its derivatives butyl methacrylate or its derivatives compound, ethylene glycol dimethacrylate or a derivative thereof, or a combination thereof.
- the "polymerizable monomer and/or polymer having a hydrophilic group” includes, but is not limited to, acrylic acid or its derivatives, acrylamide or its derivatives, vinylamide or its derivatives, vinyl A lactam (eg, NVP) or a derivative thereof, a polyethylene polyol or a derivative thereof, or a combination thereof. Because of the integrity of the cross-linked network structure of a hydrogel prepared from a polymerizable monomer or polymer having a hydrophilic group, it can swell in an aqueous solution and lock the aqueous solution without dissolving.
- Polyethylene glycol is a high molecular polymer with the chemical formula HO(CH 2 CH 2 O) n H, which has many excellent properties: water-solubility, non-volatile, biologically inert, lubricity and skin moisturizing, Soft and pleasant after use, etc., it is widely used in various medical products or pharmaceutical preparations; and polyethylene glycol can improve the biocompatibility of copolymers polymerized with other monomers.
- Siloxane is a kind of compound with silicon-oxygen-silicon (Si-O-Si) bond as skeleton, which is divided into chain H(OSiH 2 ) n OH (chain siloxane), or Cyclic ( OSiH2 ) n derivatives (cyclosiloxanes).
- the functional group R 3 Si-O- containing a single silicon atom is called siloxy.
- Siloxane is stable to heat and chemical agents, has biological inertness, is not wetted by water, and has outstanding aging resistance. It is often used as a filler for hydrophobic fiber polymers such as rubber or plastic, giving the polymer excellent reinforcement and elasticity. .
- linear polyethylene glycol is modified by organosiloxane (Siloxane) with hydrophobic active groups with good chemical stability, biological inertness and flexibility to improve the hydrophilicity of hydrophobic siloxane, thereby forming Silane-functionalized polyethylene glycol silanes, including but not limited to: mercaptosilane-modified polyethylene glycol (eg, mercapto-polyethylene glycol silane (SH-PEG-Silane)), carboxysilane-modified polyethylene glycol (eg, carboxypolyethylene glycol silane (COOH-PEG-Silane)), and methoxysilane-modified polyethylene glycols (eg, methoxypolyethylene glycol silane (mPEG-Silane)).
- organosiloxane Siloxane
- hydrophobic active groups with good chemical stability, biological inertness and flexibility to improve the hydrophilicity of hydrophobic siloxane, thereby forming Silane-functionalized poly
- the silane-functionalized polyethylene glycol comprises mercaptopolyethylene glycol silane, carboxypolyethylene glycol silane, or methoxypolyethylene glycol silane.
- the silane-functionalized polyethylene glycol can increase the hydrophobicity of the polyethylene glycol (reduce its hydrophilicity), as well as enhance the bioinertness, flexibility, chemical stability, and low water absorption of the hydrogels of the present invention.
- the hydrogel of the present invention is a water-swellable high molecular polymer with a certain degree of cross-linking, which is neither soluble in water nor insoluble in organic solvents.
- the hydrophilic group in the hydrogel has the ability to absorb the aqueous solution, and the water absorption rate is fast, and the water retention performance is good, and it is difficult to separate the water even under pressure.
- the hydrogel is prepared from polymerizable monomers and/or polymers with amphiphilic groups.
- the hydrogel is composed of a polymerizable monomer and/or polymer having an amphiphilic group and the polymerizable monomer and/or polymer having a hydrophilic group. things prepared.
- the proportion of the polymerizable monomer and/or polymer having an amphiphilic group (which has a hydrophobic group) in the hydrogel is greater than the proportion of the polymerizable monomer having a hydrophilic group A group of polymerizable monomers and/or polymers for the preparation of hydrogels with low absorption capacity for aqueous solutions.
- the proportion of the polymerizable monomer and/or polymer having an amphiphilic group in the hydrogel is greater than that of the polymerizable monomer and/or polymer having a hydrophilic group Or the weight percent of the polymer is 20%.
- the proportion of the polymerizable monomer and/or polymer having an amphiphilic group in the hydrogel is greater than that of the polymerizable monomer and/or polymer having a hydrophilic group Or the weight percent of the polymer is 30%.
- the polymerizable monomer and/or polymer, and the silane-functionalized polyethylene glycol or its derivatives account for 4 to 40% by weight of the hydrogel. In a preferred embodiment, the polymerizable monomer and/or polymer and the silane-functionalized polyethylene glycol or its derivatives account for 6 to 30% by weight of the hydrogel. In a more preferred embodiment, the polymerizable monomer and/or polymer and the silane-functionalized polyethylene glycol or its derivatives account for 8 to 20% by weight of the hydrogel.
- crosslinking agent of the present invention is not particularly limited as long as it can react with the functional group of the amphiphilic group and/or the hydrophilic group to induce crosslinking.
- Crosslinking agents herein include, but are not limited to, compounds having at least two ethylenically unsaturated groups.
- the cross-linking agent comprises N,N'-methylenebisacrylamide, ethylene glycol dimethacrylate, polyethylene glycol diacrylate, tetraethylene glycol dimethacrylate , triethylene glycol dimethacrylate, polyethylene glycol dimethacrylate, trimethyl propane trimethacrylate, vinyl methacrylate, ethylene diamine dimethyl acrylamide, dimethacrylic acid Glycerides, diethylene glycol dimethacrylate, divinylbenzene, or combinations thereof.
- the weight percentage of the crosslinking agent in the hydrogel is 0.01 to 10%. In a preferred embodiment, the weight percentage of the crosslinking agent in the hydrogel is 0.02 to 8%. In a more preferred embodiment, the weight percentage of the crosslinking agent in the hydrogel is 0.05 to 5%.
- the hydrogel comprises a soothing factor, an emollient factor, or a combination thereof.
- the soothing factor or the embellishing factor can be selectively present in the hydrogel, and the free water of the three-dimensional network structure inside the hydrogel can be replaced by the soothing factor or the emollient factor compound aqueous solution, the soothing factor or the embellishing factor
- the compound of the factor can be freely distributed in the hydrogel polymer. Therefore, when the wet dressing containing the soothing factor or emollient factor is attached to the tattoo wound, the compound of the soothing factor or emollient factor is released from the hydrogel of the wet dressing into the damaged skin, which can improve the damaged skin. Skin repair and tattoo ink color protection, and will not interact with tattoo pigments.
- the soothing factor can improve the comfort of damaged skin care, such as soothing and calming, reducing wound odor, avoiding scab and the like.
- the soothing factor is selected from collagen, hyaluronic acid, glycerin, ceramide, gelatin, antibacterial polypeptide, chitosan, chitosan, alginate, menthol, borneol ( Borneol), Frankincense, derivatives thereof and combinations thereof.
- the embellishment factor can moisturize and protect the color, such as moisturizing, bright color, embellishment and the like.
- the embellishment factor is selected from Glycyrrhizic acid, Salvia miltiorrhiza, Allantoin, Aloe, Arbutin, Vitamin A, Vitamin D, Vitamin E, Vitamin C, Salicylic acid, Ellagic acid, Kojic acid, Chamomile ET, 5,5'-dipropylbiphenyl-2, 2'-Diol (5,5'-Dipropyl-Biphenyl-2,2'-diol), derivatives thereof and combinations thereof.
- the soothing factor or embellishment factor accounts for 0.01 to 10% by weight of the composition of the hydrogel.
- the embellishment factor comprises Potassium Methoxysalicylate, Aloe, or a combination thereof.
- the moisturizing factor has moisturizing and color-protecting effects, and comprises 0.2% potassium methoxysalicylate, 1% aloe vera (Aloe) or a combination thereof.
- the emollient factor comprises arbutin, and the soothing factor comprises hyaluronic acid.
- the soothing factor or the emollient factor has a moisturizing and color-protecting effect, wherein the emollient factor contains 0.1% arbutin, and the soothing factor contains 0.5% hyaluronic acid.
- the wet dressing has the functions of protecting and isolating, moisturizing, moisturizing and other wound care and tattoo color protection.
- the hydrogel comprises a soothing factor, an emollient factor, or a combination thereof.
- the hydrogel does not contain harsh ingredients, such as gelling agents, thickening agents, preservatives, and/or cooling agents.
- the wet dressing of the present invention has a high water content (50% or more), so that the skin can be hydrated when there is little or no exudate from the wound.
- the wet dressing has a low ability to absorb aqueous solutions and is suitable for tattoo wounds with less exudate . Therefore, the wet dressing of the present invention can maintain the proper moist balance of tattoo damaged skin, accelerate the damaged skin to pass the inflammatory period and promote healing, help the deposition of ink in the dermis layer of the skin, and maintain the technical quality and visual quality of tattoo art. beautiful.
- the present invention further provides a method for color protection and color development of a fresh tattoo pattern, comprising: (a) applying the fresh tattoo pattern on the skin of an individual; and (b) attaching a wet dressing to the tattoo pattern, wherein
- the wet dressing comprises a hydrogel (Hydrogel), wherein the water content of the hydrogel is greater than 50% by weight, and the aqueous solution absorption capacity is not greater than 5 g/g. Therefore, the wet dressing can be used to maintain the shape of the tattoo pattern and the effect of developing the color of the tattoo pigment.
- the damaged skin at the tattoo pattern has been subjected to wound cleaning treatment.
- the individual is a mammal. In a preferred embodiment, the individual is a human.
- the step (b) further comprises attaching the wet dressing to the tattooed pattern within 2 hours after the tattooing. In a preferred embodiment, the step (b) further comprises attaching the wet dressing to the tattoo pattern within 1 hour after the tattoo. In a more preferred embodiment, the step (b) further comprises attaching the wet dressing to the tattooed pattern within 30 minutes after the tattooing.
- the step (b) further comprises a step (b1), wherein the step (b1) comprises removing the wet dressing 48 hours after the wet dressing is attached to the tattoo pattern, and reapplying Apply a new wet dressing to the tattoo.
- the step (b) further includes a step (b1), wherein the step (b1) includes removing the wet dressing 24 hours after the wet dressing is attached to the tattoo pattern, and re-applied. Apply a new wet dressing over the tattoo.
- the step (b1) is repeated 6 times. In a preferred embodiment, the step (b1) is repeated four times. In a more preferred embodiment, the step (b1) is repeated twice. In addition, after the step (b1) is repeated several times, the wet dressing is finally completely removed from the tattoo pattern.
- the wet dressing further comprises a sheet adhered to the hydrogel.
- the surface area of the adhesive surface of the sheet is larger than the surface area of the hydrogel. Therefore, the adhesive surface of the sheet has more attachment areas outside the hydrogel.
- the embodiment of the wet dressing is a solid sheet dressing.
- the sheet has the function of waterproof and breathable.
- the sheet is made of polyurethane.
- the aqueous solution absorption capacity of the hydrogel is not greater than 3 g/g. In a more preferred embodiment, the aqueous solution absorption capacity of the hydrogel is not greater than 2 g/g.
- the hydrogel is formed by the reaction and polymerization of a plurality of reactants; wherein the plurality of reactants comprise polymerizable monomers and/or polymers, silane-functionalized polyethylene glycols, or the like. derivatives, and cross-linking agents.
- the polymerizable monomer and/or polymer has an amphiphile and/or a hydrophilic group.
- the weight percent of the polymerizable monomer and/or polymer and the silane-functionalized polyethylene glycol or derivatives thereof is 4 to 40% of the hydrogel.
- the cross-linkable polymerizable monomer and/or polymer and the silane-functionalized polyethylene glycol or its derivatives account for 6 to 30% by weight of the hydrogel .
- the polymerizable monomer and/or polymer and the silane-functionalized polyethylene glycol or its derivatives account for 8 to 20% by weight of the hydrogel.
- the proportion of the polymerizable monomer and/or polymer having an amphiphilic group in the hydrogel is greater than that of the polymerizable monomer and/or polymer having a hydrophilic group
- the weight percentage of the material is 20%.
- the proportion of the polymerizable monomer and/or polymer having an amphiphilic group in the hydrogel is greater than that of the polymerizable monomer and/or polymer having a hydrophilic group Or the weight percent of the polymer is 30%.
- the weight percentage of the crosslinking agent in the hydrogel is 0.01 to 10%. In a preferred embodiment, the weight percentage of the crosslinking agent in the hydrogel is 0.02 to 8%. In a more preferred embodiment, the weight percentage of the crosslinking agent in the hydrogel is 0.05 to 5%.
- the hydrogel comprises a soothing factor, an emollient factor, or a combination thereof.
- the soothing factor is selected from collagen, hyaluronic acid, glycerin, ceramide, gelatin, antibacterial polypeptide, chitosan, chitosan, alginate, menthol, borneol, frankincense, etc. Derivatives and their combinations.
- the embellishment factor is selected from glycyrrhizic acid, salvia, allantoin, aloe vera, arbutin, vitamin A, vitamin D, vitamin E, vitamin C, salicylic acid, ellagic acid, kojic acid , chamomile extract, 5,5'-dipropylbiphenyl-2,2'-diol, derivatives thereof, and combinations thereof.
- the soothing factor or the embellishment factor accounts for 0.01 to 10% by weight of the composition of the hydrogel.
- the embellishment factor comprises Potassium Methoxysalicylate, Aloe, or a combination thereof.
- the moisturizing factor has moisturizing and color-protecting effects, and comprises 0.2% potassium methoxysalicylate, 1% aloe vera or a combination thereof.
- the emollient factor comprises arbutin
- the soothing factor comprises hyaluronic acid
- the present invention further provides a composition for preparing a pharmaceutical composition for caring for freshly tattooed damaged skin and maintaining the tattoo pattern and its color, wherein the composition comprises a wet dressing, wherein the wet dressing comprises a hydrogel, wherein the water The weight percentage of the water content of the gel is greater than 50%, and the absorption capacity of the aqueous solution is not greater than 5 g/g. Therefore, the wet dressing is used to stick to the freshly tattooed skin after tattooing, to care for the damaged skin after the freshly tattooed, and to contribute to the artistic beauty of the tattooed pattern and the pigment in the skin.
- the wet dressing further comprises a sheet adhered to the hydrogel.
- the surface area of the adhesive surface of the sheet is larger than the surface area of the hydrogel. Therefore, the adhesive surface of the sheet has more attachment areas outside the hydrogel.
- the embodiment of the wet dressing is a solid sheet dressing.
- the sheet has the function of waterproof and breathable.
- the sheet is made of polyurethane.
- the aqueous solution absorption capacity of the hydrogel is not greater than 3 g/g. In a more preferred embodiment, the aqueous solution absorption capacity of the hydrogel is not greater than 2 g/g.
- the hydrogel is formed by the reaction polymerization of a plurality of reactants, wherein the plurality of reactants include polymerizable monomers and/or polymers, silane-functionalized polyethylene glycols, or the like. derivatives, and cross-linking agents.
- the polymerizable monomer and/or polymer has an amphiphilic group and/or a hydrophilic group.
- the polymerizable monomer and/or polymer and the silane-functionalized polyethylene glycol or its derivatives account for 4 to 40% by weight of the hydrogel.
- the polymerizable monomer and/or polymer having a hydrophilic group and the silane-functionalized polyethylene glycol or its derivatives account for the weight percent of the hydrogel 6 to 30%.
- the polymerizable monomer and/or polymer having a hydrophilic group and the silane-functionalized polyethylene glycol or its derivatives account for the weight percent of the hydrogel 8 to 20%.
- the proportion of the polymerizable monomer and/or polymer having an amphiphilic group in the hydrogel is greater than that of the polymerizable monomer and/or polymer having a hydrophilic group
- the weight percentage of the material is 20%.
- the proportion of the polymerizable monomer and/or polymer having an amphiphilic group in the hydrogel is greater than that of the crosslinkable monomer having a hydrophilic group and /or the weight percent of the polymer is 30%.
- the weight percentage of the crosslinking agent in the hydrogel is 0.01 to 10%. In a preferred embodiment, the weight percentage of the crosslinking agent in the hydrogel is 0.02 to 8%. In a more preferred embodiment, the weight percentage of the crosslinking agent in the hydrogel is 0.05 to 5%.
- the hydrogel comprises a soothing factor, an emollient factor, or a combination thereof.
- the soothing factor is selected from collagen, hyaluronic acid, glycerin, ceramide, gelatin, antibacterial polypeptide, chitosan, chitosan, alginate, menthol, borneol, frankincense, etc. Derivatives and their combinations.
- the embellishment factor is selected from glycyrrhizic acid, salvia, allantoin, aloe vera, arbutin, vitamin A, vitamin D, vitamin E, vitamin C, salicylic acid, ellagic acid, kojic acid , chamomile extract, 5,5'-dipropylbiphenyl-2,2'-diol, derivatives thereof, and combinations thereof.
- the soothing factor or the embellishment factor accounts for 0.01 to 10% by weight of the composition of the hydrogel.
- the present invention provides a method for preparing a hydrogel, comprising: mixing a polymerizable monomer and/or polymer, a silane-functionalized polyethylene glycol or a derivative thereof, and a cross-linking agent to obtain a mixture , and make the mixture undergo cross-linking polymerization to obtain the hydrogel.
- the polymerizable monomer and/or polymer has an amphiphile and/or a hydrophilic group.
- the polymerizable monomer and/or polymer having an amphiphilic group comprises methacrylate- ⁇ -hydroxyethyl ester or its derivatives, methacrylamide or its derivatives, Glyceryl methacrylate or its derivatives, 2-hydroxyethylmethacrylamide or its derivatives, polyethylene glycol methacrylate or its derivatives, butyl methacrylate or its derivatives, dimethyl methacrylate Ethylene glycol acrylate or a derivative thereof or a combination thereof.
- the polymerizable monomer and/or polymer having a hydrophilic group comprises acrylic acid or its derivatives, acrylamide or its derivatives, vinyl amide or its derivatives, vinyl lactam (eg NVP) or derivatives thereof, polyethylene polyols or derivatives thereof, or combinations thereof.
- the silane-functionalized polyethylene glycol comprises mercaptopolyethylene glycol silane, carboxypolyethylene glycol silane, or methoxypolyethylene glycol silane.
- the weight percent of the polymerizable monomer and/or polymer and the silane-functionalized polyethylene glycol or derivatives thereof is 4 to 40% of the hydrogel.
- the polymerizable monomer and/or polymer and the silane-functionalized polyethylene glycol or its derivatives account for 6 to 30% by weight of the hydrogel.
- the polymerizable monomer and/or polymer and the silane-functionalized polyethylene glycol or its derivatives account for 8 to 20% by weight of the hydrogel.
- the proportion of the polymerizable monomer and/or polymer having an amphiphilic group in the hydrogel is greater than that of the polymerizable monomer and/or polymer having a hydrophilic group
- the weight percentage of the material is 20%.
- the proportion of the polymerizable monomer and/or polymer having an amphiphilic group in the hydrogel is greater than that of the polymerizable monomer and/or polymer having a hydrophilic group Or the weight percent of the polymer is 30%.
- the absorption capacity of the glue to the aqueous solution is not more than 5g/g.
- the cross-linking agent comprises N,N'-methylenebisacrylamide, ethylene glycol dimethacrylate, polyethylene glycol diacrylate, tetraethylene glycol dimethacrylate , triethylene glycol dimethacrylate, polyethylene glycol dimethacrylate, trimethyl propane trimethacrylate, vinyl methacrylate, ethylene diamine dimethyl acrylamide, dimethacrylic acid Glycerides, diethylene glycol dimethacrylate, divinylbenzene, or combinations thereof.
- the weight percentage of the crosslinking agent in the hydrogel is 0.01 to 10%. In a preferred embodiment, the weight percentage of the crosslinking agent in the hydrogel is 0.02 to 8%. In a more preferred embodiment, the weight percentage of the crosslinking agent in the hydrogel is 0.05 to 5%.
- the weight percentage of the water in the hydrogel is more than 50%.
- the preparation method further comprises adding a soothing factor, an emollient factor or a combination thereof to the mixture.
- the soothing factor or embellishment factor accounts for 0.01 to 10% by weight of the composition of the hydrogel.
- the soothing factor is selected from collagen, hyaluronic acid, glycerin, ceramide, gelatin, antibacterial polypeptide, chitosan, chitosan, alginate, menthol, borneol, frankincense and the like. derivatives or combinations thereof.
- the embellishment factor is selected from glycyrrhizic acid, salvia, allantoin, aloe vera, arbutin, vitamin A, vitamin D, vitamin E, vitamin C, salicylic acid, ellagic acid, kojic acid , chamomile extract, 5,5'-dipropylbiphenyl-2,2'-diol, derivatives thereof, and combinations thereof.
- the mixture is polymerized by cross-linking by heat, light, radiation or other means to form the hydrogel.
- the method further comprises adhering a sheet to the hydrogel.
- the surface area of the adhesive surface of the sheet is larger than the surface area of the hydrogel.
- the present invention provides a wet dressing for post-tattoo care, so that fresh tattoos have medical-grade repair and professional artistic aesthetic presentation; protect and isolate tattoo wounds from infection, and are not subject to adhesion and friction of daily contact items such as clothes and quilts, etc. It is waterproof and breathable, which can reduce wound ulceration, inconvenience in bathing, and ink dilution and dissipation, moisturizing and color protection, and promoting pigment color adhesion, perfectly showing the visual beauty of tattoo art.
- FIG. 1 is a schematic side view of the structure of the wet dressing of the present invention.
- FIG. 2 is a schematic diagram of using the wet dressing of the present invention to stick to the tattoo.
- amphiphilic group of methacrylate- ⁇ -hydroxyethyl ester 6 grams, the hydrophilic group of acrylamide 2 grams, mercapto polyethylene glycol silane 2 grams, N,N'-methylenebisacrylamide 0.2 gram (crosslinking agent), 0.2 gram of Irgacure 2959 photoinitiator (purchased from BASF) and water were mixed to 100 grams, the aforesaid solution that was stirred evenly was moved to the polymerization reaction mold, and under ultraviolet light irradiation, The solution in the reaction mold undergoes a cross-linking polymerization reaction to form a hydrogel with a solid sheet-like three-dimensional network structure.
- the weight percentage of the water content of the hydrogel is greater than 80%, and the absorption of the aqueous solution is not greater than 2 g/g.
- the wet dressing 10 includes a sheet 101 with waterproof and breathable functions and a hydrogel 102 , wherein the sheet 101 has a two-sided structure, one of which is an adhesive surface (The adhesive surface is not shown), the adhesive surface has an adhesive, and the adhesive surface is bonded with the hydrogel 102 , so that the sheet 101 and the hydrogel 102 form the wet dressing 10 .
- the surface area of the sheet 101 is larger than the surface area of the hydrogel 102 , so the adhesive surface of the sheet 101 has an extra adhesive area outside the hydrogel 102 for adhering the wet dressing 10 to the skin.
- the wet dressing is used as follows: within 2 hours after the tattoo, first clean the affected part of the tattoo 201 with clean cold water, and then gently remove the bleeding, exudate, ink, etc. from the fresh tattoo 201 with a clean gauze
- the wet dressing 20 of the present case is attached to the affected part of the tattoo 201, and the dressing is changed every 0.5 to 2 days (the replacement frequency is adjusted according to the amount of bleeding and exudate).
- Example 1 According to the preparation method of Example 1, but adding 0.5g hyaluronic acid (soothing factor) and 0.1g arbutin (embellishing factor) to the 100g solution prepared in Example 1, after cross-linking polymerization reaction, a solid state was formed.
- the arbutin hydrogel with a hyaluronic acid concentration of 0.5% in a flake-shaped three-dimensional network structure has a water content of more than 75% and an absorption of an aqueous solution of not more than 2g/g. Then, the hydrogel with arbutin/hyaluronic acid is combined with the film with waterproof and breathable function to form a surrounding self-adhesive wet dressing containing arbutin/hyaluronic acid.
- the method of using the wet dressing is also to clean the affected part of the tattoo with clean cold water, and then use a clean gauze to gently remove the bleeding, exudate, ink and other substances from the fresh tattoo. Change the dressing every 0.5 to 2 days (adjust the replacement frequency according to the amount of bleeding and exudate).
- Example 1 The wet dressing of Example 1 was compared with the silicone-free hydrogel (does not contain compounds with silicon molecules) dressings on the market (as a comparative example), and the mechanical properties before and after immersion in physiological saline were measured respectively. properties, and the test results are shown in Table 1.
- the dressings of the above-mentioned different embodiments were used. 3), each find 4 people to carry out nursing experiment after fresh tattoo, measure its index for tattoo repair respectively, and its test result is shown in table 2 below.
- the wet dressing of the present invention is better than the dressings of other groups in terms of color protection, protection and isolation, and wound repair of the tattoo color.
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Abstract
Pansement humide hydratant et protecteur de couleur (10). Le pansement humide (10) présente des caractéristiques d'une haute teneur en eau et d'une faible capacité d'absorption d'une solution aqueuse. Le pansement humide (10) est utilisé pour réparer une peau lésée après un tatouage frais et protéger la couleur de l'encre de tatouage, fournit une réparation de qualité médicale à la peau lésée après tatouage, réalise une protection et une isolation, maintient l'humidité, et aide au dépôt de l'encre de tatouage dans la peau pour améliorer la beauté artistique des tatouages.
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PCT/CN2021/090790 WO2022226857A1 (fr) | 2021-04-29 | 2021-04-29 | Pansement humide destiné à la protection de couleur de tatouage et son procédé d'utilisation |
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PCT/CN2021/090790 WO2022226857A1 (fr) | 2021-04-29 | 2021-04-29 | Pansement humide destiné à la protection de couleur de tatouage et son procédé d'utilisation |
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6706279B1 (en) * | 2000-10-17 | 2004-03-16 | Pharma Mag Inc. | Wound dressing |
CN107029275A (zh) * | 2016-02-04 | 2017-08-11 | 王芷尧 | 湿式敷料 |
CN110114097A (zh) * | 2016-12-23 | 2019-08-09 | 保罗·哈特曼股份公司 | 用于包扎伤口的含水水凝胶 |
CN112206093A (zh) * | 2019-07-10 | 2021-01-12 | 广西美丽肤医疗器械有限公司 | 防水透气湿式敷料 |
CN112261956A (zh) * | 2018-05-14 | 2021-01-22 | 保赫曼有限公司 | 功能性伤口敷料 |
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2021
- 2021-04-29 WO PCT/CN2021/090790 patent/WO2022226857A1/fr active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
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US6706279B1 (en) * | 2000-10-17 | 2004-03-16 | Pharma Mag Inc. | Wound dressing |
CN107029275A (zh) * | 2016-02-04 | 2017-08-11 | 王芷尧 | 湿式敷料 |
CN110114097A (zh) * | 2016-12-23 | 2019-08-09 | 保罗·哈特曼股份公司 | 用于包扎伤口的含水水凝胶 |
CN112261956A (zh) * | 2018-05-14 | 2021-01-22 | 保赫曼有限公司 | 功能性伤口敷料 |
CN112206093A (zh) * | 2019-07-10 | 2021-01-12 | 广西美丽肤医疗器械有限公司 | 防水透气湿式敷料 |
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