WO2022130632A1 - Fil de guidage et procédé de fabrication de fil de guidage - Google Patents
Fil de guidage et procédé de fabrication de fil de guidage Download PDFInfo
- Publication number
- WO2022130632A1 WO2022130632A1 PCT/JP2020/047510 JP2020047510W WO2022130632A1 WO 2022130632 A1 WO2022130632 A1 WO 2022130632A1 JP 2020047510 W JP2020047510 W JP 2020047510W WO 2022130632 A1 WO2022130632 A1 WO 2022130632A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- guide wire
- layer
- functional group
- fluororesin
- resin
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 33
- 238000000034 method Methods 0.000 title abstract description 39
- 229920005989 resin Polymers 0.000 claims abstract description 81
- 239000011347 resin Substances 0.000 claims abstract description 81
- 239000002245 particle Substances 0.000 claims abstract description 55
- 125000000524 functional group Chemical group 0.000 claims abstract description 49
- 239000000853 adhesive Substances 0.000 claims abstract description 46
- 230000001070 adhesive effect Effects 0.000 claims abstract description 46
- 239000002184 metal Substances 0.000 claims abstract description 22
- 238000010304 firing Methods 0.000 claims abstract description 16
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 12
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 12
- -1 polytetrafluoroethylene Polymers 0.000 claims description 8
- 229920013653 perfluoroalkoxyethylene Polymers 0.000 claims description 6
- 230000002093 peripheral effect Effects 0.000 claims description 6
- 229920000642 polymer Polymers 0.000 claims description 5
- 230000003746 surface roughness Effects 0.000 claims description 5
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 claims description 3
- HCDGVLDPFQMKDK-UHFFFAOYSA-N hexafluoropropylene Chemical group FC(F)=C(F)C(F)(F)F HCDGVLDPFQMKDK-UHFFFAOYSA-N 0.000 claims description 2
- 239000010410 layer Substances 0.000 description 84
- 239000011162 core material Substances 0.000 description 47
- 239000004840 adhesive resin Substances 0.000 description 28
- 229920006223 adhesive resin Polymers 0.000 description 28
- 238000000576 coating method Methods 0.000 description 16
- 239000011248 coating agent Substances 0.000 description 15
- 239000000178 monomer Substances 0.000 description 15
- 229910052731 fluorine Inorganic materials 0.000 description 10
- 239000006185 dispersion Substances 0.000 description 8
- 235000019000 fluorine Nutrition 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 6
- 239000011737 fluorine Substances 0.000 description 6
- 239000012298 atmosphere Substances 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 230000009257 reactivity Effects 0.000 description 5
- BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical group FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 description 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 4
- 125000001153 fluoro group Chemical group F* 0.000 description 4
- 238000002844 melting Methods 0.000 description 4
- 230000008018 melting Effects 0.000 description 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 239000012790 adhesive layer Substances 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 3
- 239000012986 chain transfer agent Substances 0.000 description 3
- 238000006116 polymerization reaction Methods 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 2
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 2
- 229910045601 alloy Inorganic materials 0.000 description 2
- 239000000956 alloy Substances 0.000 description 2
- IAQRGUVFOMOMEM-UHFFFAOYSA-N but-2-ene Chemical compound CC=CC IAQRGUVFOMOMEM-UHFFFAOYSA-N 0.000 description 2
- 125000005587 carbonate group Chemical group 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 125000001309 chloro group Chemical group Cl* 0.000 description 2
- NEHMKBQYUWJMIP-UHFFFAOYSA-N chloromethane Chemical compound ClC NEHMKBQYUWJMIP-UHFFFAOYSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 239000002612 dispersion medium Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- QWTDNUCVQCZILF-UHFFFAOYSA-N isopentane Chemical compound CCC(C)C QWTDNUCVQCZILF-UHFFFAOYSA-N 0.000 description 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 2
- 239000003505 polymerization initiator Substances 0.000 description 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
- KDGNCLDCOVTOCS-UHFFFAOYSA-N (2-methylpropan-2-yl)oxy propan-2-yl carbonate Chemical compound CC(C)OC(=O)OOC(C)(C)C KDGNCLDCOVTOCS-UHFFFAOYSA-N 0.000 description 1
- NOBYOEQUFMGXBP-UHFFFAOYSA-N (4-tert-butylcyclohexyl) (4-tert-butylcyclohexyl)oxycarbonyloxy carbonate Chemical compound C1CC(C(C)(C)C)CCC1OC(=O)OOC(=O)OC1CCC(C(C)(C)C)CC1 NOBYOEQUFMGXBP-UHFFFAOYSA-N 0.000 description 1
- BQCIDUSAKPWEOX-UHFFFAOYSA-N 1,1-Difluoroethene Chemical compound FC(F)=C BQCIDUSAKPWEOX-UHFFFAOYSA-N 0.000 description 1
- NPNPZTNLOVBDOC-UHFFFAOYSA-N 1,1-difluoroethane Chemical compound CC(F)F NPNPZTNLOVBDOC-UHFFFAOYSA-N 0.000 description 1
- VAYTZRYEBVHVLE-UHFFFAOYSA-N 1,3-dioxol-2-one Chemical compound O=C1OC=CO1 VAYTZRYEBVHVLE-UHFFFAOYSA-N 0.000 description 1
- SJGGAMMXIZFWSF-UHFFFAOYSA-N 2,3,3-trifluoroprop-2-enoyl fluoride Chemical compound FC(F)=C(F)C(F)=O SJGGAMMXIZFWSF-UHFFFAOYSA-N 0.000 description 1
- VAJGLWNYOMVAOX-UHFFFAOYSA-N 2,3,4,4,4-pentafluorobut-2-enoic acid Chemical compound OC(=O)C(F)=C(F)C(F)(F)F VAJGLWNYOMVAOX-UHFFFAOYSA-N 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- OEPOKWHJYJXUGD-UHFFFAOYSA-N 2-(3-phenylmethoxyphenyl)-1,3-thiazole-4-carbaldehyde Chemical compound O=CC1=CSC(C=2C=C(OCC=3C=CC=CC=3)C=CC=2)=N1 OEPOKWHJYJXUGD-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- QMIWYOZFFSLIAK-UHFFFAOYSA-N 3,3,3-trifluoro-2-(trifluoromethyl)prop-1-ene Chemical compound FC(F)(F)C(=C)C(F)(F)F QMIWYOZFFSLIAK-UHFFFAOYSA-N 0.000 description 1
- JGZVUTYDEVUNMK-UHFFFAOYSA-N 5-carboxy-2',7'-dichlorofluorescein Chemical compound C12=CC(Cl)=C(O)C=C2OC2=CC(O)=C(Cl)C=C2C21OC(=O)C1=CC(C(=O)O)=CC=C21 JGZVUTYDEVUNMK-UHFFFAOYSA-N 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- PYVHTIWHNXTVPF-UHFFFAOYSA-N F.F.F.F.C=C Chemical compound F.F.F.F.C=C PYVHTIWHNXTVPF-UHFFFAOYSA-N 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 1
- 125000004018 acid anhydride group Chemical group 0.000 description 1
- HFBMWMNUJJDEQZ-UHFFFAOYSA-N acryloyl chloride Chemical compound ClC(=O)C=C HFBMWMNUJJDEQZ-UHFFFAOYSA-N 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 125000003368 amide group Chemical group 0.000 description 1
- 230000002785 anti-thrombosis Effects 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000012662 bulk polymerization Methods 0.000 description 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 1
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 description 1
- 125000005708 carbonyloxy group Chemical group [*:2]OC([*:1])=O 0.000 description 1
- VZBZCLRLPBEOBO-UHFFFAOYSA-N carboxyoxy octan-3-yl carbonate Chemical compound CCCCCC(CC)OC(=O)OOC(O)=O VZBZCLRLPBEOBO-UHFFFAOYSA-N 0.000 description 1
- KYKAJFCTULSVSH-UHFFFAOYSA-N chloro(fluoro)methane Chemical compound F[C]Cl KYKAJFCTULSVSH-UHFFFAOYSA-N 0.000 description 1
- UUAGAQFQZIEFAH-UHFFFAOYSA-N chlorotrifluoroethylene Chemical group FC(F)=C(F)Cl UUAGAQFQZIEFAH-UHFFFAOYSA-N 0.000 description 1
- 238000004581 coalescence Methods 0.000 description 1
- AFABGHUZZDYHJO-UHFFFAOYSA-N dimethyl butane Natural products CCCC(C)C AFABGHUZZDYHJO-UHFFFAOYSA-N 0.000 description 1
- XNMQEEKYCVKGBD-UHFFFAOYSA-N dimethylacetylene Natural products CC#CC XNMQEEKYCVKGBD-UHFFFAOYSA-N 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000007720 emulsion polymerization reaction Methods 0.000 description 1
- HQQADJVZYDDRJT-UHFFFAOYSA-N ethene;prop-1-ene Chemical group C=C.CC=C HQQADJVZYDDRJT-UHFFFAOYSA-N 0.000 description 1
- XUCNUKMRBVNAPB-UHFFFAOYSA-N fluoroethene Chemical compound FC=C XUCNUKMRBVNAPB-UHFFFAOYSA-N 0.000 description 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 1
- 238000010528 free radical solution polymerization reaction Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 150000008282 halocarbons Chemical class 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000005462 imide group Chemical group 0.000 description 1
- KHYBPSFKEHXSLX-UHFFFAOYSA-N iminotitanium Chemical compound [Ti]=N KHYBPSFKEHXSLX-UHFFFAOYSA-N 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 230000009878 intermolecular interaction Effects 0.000 description 1
- IQPQWNKOIGAROB-UHFFFAOYSA-N isocyanate group Chemical group [N-]=C=O IQPQWNKOIGAROB-UHFFFAOYSA-N 0.000 description 1
- 238000007561 laser diffraction method Methods 0.000 description 1
- 238000010309 melting process Methods 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 229940050176 methyl chloride Drugs 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910001000 nickel titanium Inorganic materials 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 125000003355 oxamoyl group Chemical group C(C(=O)N)(=O)* 0.000 description 1
- MMCOUVMKNAHQOY-UHFFFAOYSA-L oxido carbonate Chemical compound [O-]OC([O-])=O MMCOUVMKNAHQOY-UHFFFAOYSA-L 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- TYRXZPXAGPSIDU-UHFFFAOYSA-N prop-2-enoic acid hydrofluoride Chemical compound F.C(C=C)(=O)O TYRXZPXAGPSIDU-UHFFFAOYSA-N 0.000 description 1
- BWJUFXUULUEGMA-UHFFFAOYSA-N propan-2-yl propan-2-yloxycarbonyloxy carbonate Chemical compound CC(C)OC(=O)OOC(=O)OC(C)C BWJUFXUULUEGMA-UHFFFAOYSA-N 0.000 description 1
- YPVDWEHVCUBACK-UHFFFAOYSA-N propoxycarbonyloxy propyl carbonate Chemical compound CCCOC(=O)OOC(=O)OCCC YPVDWEHVCUBACK-UHFFFAOYSA-N 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000000790 scattering method Methods 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000010557 suspension polymerization reaction Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/09—Guide wires
Definitions
- the present invention relates to a method for manufacturing a guide wire and a guide wire.
- a guide wire is used to guide the medical device to the treatment site.
- a fluororesin such as PTFE or PFA is applied to the outermost surface of the metal core wire so that the guide wire can smoothly proceed in a branched or curved blood vessel and reach the treatment site smoothly.
- a coating technique has been proposed (see, for example, Patent Document 1).
- an adhesive layer for adhering the core wire and the fluororesin is provided.
- the frictional force can be reduced by suppressing the chemical bonding force between the outermost surface of the guide wire and the inner peripheral surface of the blood vessel, and the improvement of the slidability makes it possible to reduce the frictional force in the body cavity. Smooth operation is expected.
- the present invention is to provide a method for manufacturing a guide wire and a guide wire capable of further improving the slidability in a body cavity.
- One aspect of the present disclosure is (1) [A] Using particles formed of a fluororesin having an adhesive functional group and having an average particle size of 1 ⁇ m or less specified in JIS Z 8825, the particles are coated on a metal core wire. And the process to do [B] After the step [A], a step of forming the first layer by firing the core wire coated with the particles, and a step of forming the first layer. [C] A guide comprising, after the step [B], a step of forming a second layer on the outer peripheral surface of the first layer using a resin different from the fluororesin having the adhesive functional group.
- the method for producing the wire, and (2) the resin different from the fluororesin having the adhesive functional group is polytetrafluoroethylene (PTFE), tetrafluoroethylene / perfluoroalkoxyethylene copolymer (PFA), and four.
- PTFE polytetrafluoroethylene
- PFA perfluoroalkoxyethylene copolymer
- a metal core wire, a first resin layer formed on the outer periphery of the core wire, and a second resin layer formed on the outer periphery of the first resin layer are provided.
- the first resin layer has a fluororesin having an adhesive functional group and has.
- the fluororesin having an adhesive functional group is a guide wire composed of particles having an average particle size of 1 ⁇ m or less specified in JIS Z 8825.
- a metal core wire, a first resin layer formed on the outer periphery of the core wire, and a second resin layer formed on the outer periphery of the first resin layer are provided.
- the first resin layer has a fluororesin having an adhesive functional group and has.
- the "fluororesin having an adhesive functional group” refers to a functional group that may be involved in adhesion to a material such as an adjacent resin or metal (hereinafter, also referred to as "adhesive functional group”). It means a fluororesin having. Further, the "resin different from the fluororesin having an adhesive functional group” means a resin containing no fluororesin having an adhesive functional group.
- the present invention can provide a method for manufacturing a guide wire and a guide wire capable of improving slidability in a body cavity.
- a fluororesin having an adhesive functional group having adhesiveness to both a metal and a fluororesin as a material constituting an adhesive layer for adhering the core wire and the outer layer resin is used.
- the particle size of the fluororesin particles having the adhesive functional group is relatively coarse, an uneven shape is likely to occur on the surface of the adhesive layer, and as a result, an uneven shape appears on the outermost surface, depending on the size of the uneven shape. May not provide sufficient slidability.
- a melting process at a high temperature can be considered.
- the method of performing the above-mentioned melting treatment causes a long manufacturing time.
- the fluororesin having an adhesive functional group is melted at a high temperature, the melted resin may be washed away or the melted resin may be attracted by gravity to cause a difference in thickness between the upper and lower sides.
- An object of the present disclosure is to provide a method for manufacturing a guide wire and a guide wire that can further improve the slidability in a body cavity by suppressing the unevenness appearing on the outermost surface of the guide wire.
- a resin different from the fluororesin having the adhesive functional group (hereinafter, also referred to as “coating resin”) is used, and the second layer is formed on the outer peripheral surface of the first layer. It has a forming process.
- coating resin a resin different from the fluororesin having the adhesive functional group
- Step A particles (adhesive resin particles) having an average particle size of 1 ⁇ m or less specified in JIS Z 8825, which are particles formed of a fluororesin (adhesive resin) having an adhesive functional group, are used. This is the process of applying particles onto a metal core wire.
- the core wire is a metal wire that serves as the core material of the guide wire.
- the material constituting the core wire for example, stainless steel such as SUS304, superelastic alloy such as Ni—Ti alloy, etc. are used from the viewpoint of improving the flexibility of the guide wire and imparting antithrombotic property and biocompatibility. Can be adopted.
- the dimensions of the core wire are, for example, a total length of 1,800 to 3,000 mm and an outer diameter of 0.03 mm to 0.46 mm.
- the adhesive resin is a fluororesin having an adhesive functional group.
- the adhesive resin can be composed of, for example, a polymer having a fluorine-containing ethylenic monomer unit.
- the core wire and the second layer described later can be strongly adhered by interposing the first layer formed of the adhesive resin particles between the core wire and the second layer. ..
- the polymer constituting the adhesive resin can be used alone or in combination of two or more.
- fluorine-containing ethylenic monomer examples include ethylene tetrafluoride, vinylidene fluoride, chlorotrifluoroethylene, vinyl fluoride, hexafluoropropylene, hexafluoroisobutene, and per.
- Fluorines (alkyl vinyl ethers), monomers represented by the following formula (1) and the like can be mentioned.
- CH 2 CX 1 (CF 2 ) n X 2 ... (1)
- X 1 represents a hydrogen atom or a fluorine atom
- X 2 represents a hydrogen atom, a fluorine atom or a chlorine atom
- n represents an integer of 1 to 10.
- the polymer constituting the adhesive resin may have, for example, a fluorine-free monomer unit such as a fluorine-free ethylenic monomer unit together with the fluorine-containing ethylenic monomer unit.
- a fluorine-free monomer unit such as a fluorine-free ethylenic monomer unit together with the fluorine-containing ethylenic monomer unit.
- fluorine-free ethylenic monomer giving the fluorine-free ethylenic monomer unit examples include ethylene, propylene, 1-butene, 2-butene, vinyl chloride, vinylidene chloride and the like.
- the polymer constituting the adhesive resin is preferably a tetrafluoroethylene / perfluoroalkoxyethylene copolymer (PFA).
- PFA tetrafluoroethylene / perfluoroalkoxyethylene copolymer
- the tetrafluoroethylene / perfluoroalkoxyethylene copolymer has a high melting point, good compatibility with polytetrafluoroethylene (PTFE), and high mechanical properties.
- the adhesive functional group in the adhesive resin is a functional group that can be involved in adhesion to an adjacent material such as a resin or metal.
- the adhesive functional group include a functional group capable of reacting with a polar functional group possessed by an adjacent material such as a resin or a metal, a functional group capable of intermolecular interaction such as a hydrogen bond, and the like.
- the adhesive functional group may be at least one of the main chain end and the side chain in the fluororesin.
- the adhesive functional group preferably has a carbonyl group.
- halogen atom constituting the halogenoformyl group examples include a fluorine atom and a chlorine atom.
- the carbonate group and the halogenoformyl group are preferable as the adhesive functional group from the viewpoint of improving the reactivity (adhesiveness) with the adjacent material.
- the adhesive resin particles used in this step are particles having an average particle size of 1 ⁇ m or less based on JIS Z 8825: 2013 (“particle size analysis-laser diffraction / scattering method”).
- the upper limit of the average particle size of the adhesive resin particles is preferably 0.8 ⁇ m. This makes it possible to further reduce the unevenness of the outermost surface of the guide wire.
- the lower limit of the average particle size of the adhesive resin particles is preferably 0.1 ⁇ m from the viewpoint of ease of production.
- the particle size distribution of the adhesive resin particles is preferably 0.2 to 1 ⁇ m from the viewpoint of dispersibility.
- Adhesive resin particles may be produced by mixing a polymerization initiator, a chain transfer agent, a solvent and the like in a desired ratio and polymerizing the above-mentioned monomers.
- Examples of the adhesive functional group-containing ethylenic monomer include fluorine such as perfluoroacrylic acid fluoride, 1-fluoroacrylic acid fluoride, acrylate fluoride, 1-trifluoromethacrylic acid fluoride, and perfluorobutenoic acid. Quantities: Acrylic acid, methacrylic acid, acrylic acid chloride, vinylene carbonate and the like.
- polymerization initiator examples include diisopropyl peroxydicarbonate, di-n-propylperoxydicarbonate, t-butylperoxyisopropylcarbonate, bis (4-t-butylcyclohexyl) peroxydicarbonate, and di-2-.
- peroxycarbonate such as ethylhexyl peroxydicarbonate.
- the chain transfer agent is added, for example, to adjust the molecular weight.
- examples of the chain transfer agent include hydrocarbons such as isopentane, n-pentane, n-hexane and cyclohexane; alcohols such as methanol and ethanol; halogenated hydrocarbons such as carbon tetrachloride, chloroform, methylene chloride and methyl chloride. Can be mentioned.
- Examples of the solvent include hydrochlorofluoroalkanes such as CH 3 CClF 2 , CH 3 CCl 2 F, CF 3 CF 2 CCl 2 H, CF 2 ClCF 2 CF HCl; CF 2 ClCFClCF 2 CF 3 , CF 3 CFClCFClCF 3 and the like. Chlorofluoroalkanes; CF 3 CF 2 CF 2 CF 3 , CF 3 CF 2 CF 2 CF 2 CF 3 , CF 3 CF 2 CF 2 CF 2 CF 3 and other perfluoroalkanes; Examples thereof include perfluorocycloalkanes.
- hydrochlorofluoroalkanes such as CH 3 CClF 2 , CH 3 CCl 2 F, CF 3 CF 2 CCl 2 H, CF 2 ClCF 2 CF HCl; CF 2 ClCFClCF 2 CF 3 , CF 3 CFClCFClCF 3 and the like
- polymerization method examples include solution polymerization, bulk polymerization, emulsion polymerization, suspension polymerization and the like.
- the adhesive resin particles used in [Step A] of the present disclosure may be produced, for example, by further pulverizing the particles obtained by the above polymerization method, if necessary.
- Examples of the crushing method include a method of crushing using a crushing device such as a high-pressure collision crushing device and a high-speed shear stirrer.
- the method of applying the adhesive resin particles onto the metal core wire is not particularly limited as long as the first layer having a predetermined thickness can be formed.
- a coating method for example, adhesive resin particles are dispersed in a dispersion medium to prepare a dispersion liquid, and the core wire is immersed in the dispersion liquid to coat the adhesive resin particles on the core wire (immersion method). ), A method of preparing a dispersion liquid in the same manner as described above, and spraying and applying the dispersion liquid onto the core wire (spray method) and the like.
- Step B This step is a step of forming the first layer by firing the core wire coated with the particles after the step [A].
- the strong adhesive force (adhesiveness) between the first layer and the core wire and the coating resin of the second layer has high reactivity (adhesiveness) between the adhesive functional group of the adhesive resin and the metal material constituting the core wire.
- reactivity with polar groups such as carboxy groups or hydroxyl groups present on the surface of metal core wires
- high reactivity with the coating resin constituting the second layer for example, carboxy groups or carboxy groups present on the surface of the coating resin. It is considered that this is due to the strong bonding force associated with (reactivity with polar groups such as hydroxyl groups).
- This step is a step of forming the second layer on the outer peripheral surface of the first layer by using a resin (coating resin) different from the fluororesin having the adhesive functional group after the step [B].
- resins other than the above fluororesin include nylon, urethane and the like.
- the method for forming the second layer is not particularly limited as long as a layer of a coating resin having a predetermined thickness can be formed.
- a method for forming the second layer for example, a granular coating resin is dispersed in a dispersion medium to prepare a dispersion liquid, and the core wire after forming the first layer obtained in [Step B] is placed in the dispersion liquid.
- a method of forming a second layer by immersing and drying, a dispersion liquid is prepared in the same manner as described above, sprayed onto the core wire after forming the first layer, applied, and then dried to form the second layer. How to do it, etc.
- the same firing as in the above-mentioned [Step B] may be performed.
- the firing conditions such as firing temperature, firing time, and atmosphere can be appropriately selected depending on the material constituting the second layer.
- FIGS. 1 and 2 are schematic cross-sectional views showing an embodiment of a guide wire.
- the guide wire 1 is roughly composed of a core wire 11, a first resin layer 21, and a second resin layer 31.
- the configurations of the core wire 11, the first resin layer 21, and the second resin layer 31 are the same as the configurations of the core wire, the first layer, and the second layer described in the section ⁇ Manufacturing method of guide wire>, respectively. Therefore, detailed description here will be omitted.
- the first resin layer 21 is a resin layer formed on the outer periphery of the core wire 11.
- the first resin layer 21 has a fluororesin having an adhesive functional group.
- the fluororesin having an adhesive functional group is composed of particles having an average particle size of 1 ⁇ m or less specified in JIS Z8825.
- the second resin layer 31 is a resin layer formed on the outer periphery of the first resin layer 21.
- the method for manufacturing the guide wire for example, the method described in the section ⁇ Manufacturing method for guide wire> can be adopted.
- the first resin layer has a fluororesin having an adhesive functional group, and the surface roughness on the outer surface of the second resin layer is 1 ⁇ m in the arithmetic average roughness (Ra) specified in JIS B 0601: 1994. Is less than.
- the core wire 12 is a metal wire that serves as a core material for the guide wire 2.
- the second resin layer 32 is a resin layer formed on the outer periphery of the first resin layer 22.
- the surface roughness of the outer surface 32a of the second resin layer 32 is less than 1 ⁇ m in the arithmetic mean roughness (Ra) specified in JIS B 0601: 1994.
- the method for manufacturing the guide wire 2 for example, the method described in the section ⁇ Manufacturing method for guide wire> can be adopted.
- a method for manufacturing a guide wire has been described by exemplifying a compound such as a specific monomer.
- the method for producing the guide wire of the present disclosure is not limited to the above-exemplified compounds and the like.
Abstract
Le but de la présente invention est de fournir un procédé de fabrication de fil de guidage qui permet d'améliorer la capacité de glissement dans une cavité corporelle. Ce procédé de fabrication de fil de guidage comprend : [A] une étape consistant à appliquer, à l'aide de particules qui sont constituées d'une résine fluorée ayant un groupe fonctionnel adhésif et dans lesquelles la taille de grain moyenne stipulée par JIS Z 8825 est inférieure ou égale à 1 μm, les particules sur un fil central constitué d'un métal ; [B] une étape consistant à former, après l'étape [A], une première couche par cuisson du fil central sur lequel les particules ont été appliquées ; et [C] une étape consistant à former, après l'étape [B], une seconde couche sur la surface circonférentielle externe de la première couche à l'aide d'une résine différente de la résine fluorée ayant un groupe fonctionnel adhésif.
Priority Applications (2)
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PCT/JP2020/047510 WO2022130632A1 (fr) | 2020-12-18 | 2020-12-18 | Fil de guidage et procédé de fabrication de fil de guidage |
JP2022569673A JPWO2022130632A1 (fr) | 2020-12-18 | 2020-12-18 |
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PCT/JP2020/047510 WO2022130632A1 (fr) | 2020-12-18 | 2020-12-18 | Fil de guidage et procédé de fabrication de fil de guidage |
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WO2022130632A1 true WO2022130632A1 (fr) | 2022-06-23 |
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Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004130123A (ja) * | 2002-09-20 | 2004-04-30 | Ist:Kk | 医療用ガイドワイヤー及びその製造方法 |
JP2008220789A (ja) * | 2007-03-14 | 2008-09-25 | Terumo Corp | ガイドワイヤ |
JP2013192885A (ja) * | 2012-03-22 | 2013-09-30 | Terumo Corp | 医療用具およびその製造方法 |
JP2013255694A (ja) * | 2012-06-13 | 2013-12-26 | Asahi Intecc Co Ltd | ガイドワイヤ |
JP2015100664A (ja) * | 2013-11-28 | 2015-06-04 | 住友電気工業株式会社 | フッ素コートワイヤー |
WO2018181187A1 (fr) * | 2017-03-30 | 2018-10-04 | テルモ株式会社 | Instrument médical |
-
2020
- 2020-12-18 JP JP2022569673A patent/JPWO2022130632A1/ja active Pending
- 2020-12-18 WO PCT/JP2020/047510 patent/WO2022130632A1/fr active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004130123A (ja) * | 2002-09-20 | 2004-04-30 | Ist:Kk | 医療用ガイドワイヤー及びその製造方法 |
JP2008220789A (ja) * | 2007-03-14 | 2008-09-25 | Terumo Corp | ガイドワイヤ |
JP2013192885A (ja) * | 2012-03-22 | 2013-09-30 | Terumo Corp | 医療用具およびその製造方法 |
JP2013255694A (ja) * | 2012-06-13 | 2013-12-26 | Asahi Intecc Co Ltd | ガイドワイヤ |
JP2015100664A (ja) * | 2013-11-28 | 2015-06-04 | 住友電気工業株式会社 | フッ素コートワイヤー |
WO2018181187A1 (fr) * | 2017-03-30 | 2018-10-04 | テルモ株式会社 | Instrument médical |
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