WO2022024433A1 - 電解質分析装置 - Google Patents

電解質分析装置 Download PDF

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Publication number
WO2022024433A1
WO2022024433A1 PCT/JP2021/007995 JP2021007995W WO2022024433A1 WO 2022024433 A1 WO2022024433 A1 WO 2022024433A1 JP 2021007995 W JP2021007995 W JP 2021007995W WO 2022024433 A1 WO2022024433 A1 WO 2022024433A1
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Prior art keywords
ion
electrode
cover
sample
unit
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PCT/JP2021/007995
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English (en)
French (fr)
Japanese (ja)
Inventor
望 長谷川
悟郎 吉田
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株式会社日立ハイテク
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Priority to JP2022540001A priority Critical patent/JP7378628B2/ja
Publication of WO2022024433A1 publication Critical patent/WO2022024433A1/ja

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems

Definitions

  • the present invention relates to an electrolyte analyzer.
  • the electrolyte analyzer is a device that measures the concentration of a specific electrolyte contained in the electrolyte solution of human blood, urine, etc., and measures the concentration using an ion-selective electrode.
  • a flow type electrolyte analyzer is known. In the flow type electrolyte analyzer, a sample solution obtained by directly diluting serum as an electrolyte solution or diluted with a sample diluent is supplied to an ion-selective electrode, and the liquid potential between the ion-selective electrode and the comparative electrode solution is measured. ..
  • a standard solution having a known electrolyte concentration is supplied to the ion-selective electrode, and the liquid potential with the comparative electrode solution is measured in the same manner as the serum (or sample solution). Then, the electrolyte concentration of serum (or sample solution) can be calculated from the two liquid potentials of the standard solution and the serum (or sample solution).
  • the ion-selective electrode used in such a flow-type electrolyte analyzer has a limited expiration date and the number of measurements, and requires regular replacement. Therefore, for example, when the ion-selective electrode reaches the expiration date during the analysis, the analysis cannot be performed until the ion-selective electrode is replaced with a new ion-selective electrode, resulting in a decrease in processing capacity.
  • Patent Document 1 in a biofluid analyzer including a sensor group composed of a plurality of electrochemical sensors, a plurality of sensor groups including the same electrochemical sensor as the sensor included in the sensor group are provided.
  • a biofluid analyzer is disclosed in which the sensors are arranged in parallel with each other and one of the sensor groups can be selected at the time of sample measurement.
  • the sample probe may interfere with the sample probe when opening the cover covering a plurality of sensors arranged in parallel. Therefore, it is necessary to interrupt the analysis when exchanging the sensors. There is a problem that the processing capacity is reduced.
  • the present invention has been made in view of the above, and an object of the present invention is to provide an electrolyte analyzer capable of exchanging an ion-selective electrode while suppressing a decrease in processing capacity.
  • the present application includes a plurality of means for solving the above problems, for example, a diluting tank for diluting a sample dispensed by a sample probe and a specific ion in the sample diluted in the diluting tank.
  • a plurality of electrode unit units each having an ion-selective electrode for measuring a concentration are provided, and at least one electrode unit among the plurality of electrode units is below the operating range of the sample probe and above the diluting tank.
  • a detachably arranged first cover having an opening provided for the probe portion to descend to the diluting tank, and above the ion-selective electrode in a range not below the operating range of the sample probe. It shall have a second cover that is detachably arranged so as to cover the above.
  • the ion-selective electrode can be replaced while suppressing the decrease in processing capacity.
  • FIG. 1 is a diagram schematically showing the overall configuration of the electrolyte analyzer according to the embodiment of the present invention.
  • a flow-type electrolyte analyzer using an ion-selective electrode (ISE: Ion Selective Electrode) (hereinafter, simply referred to as an electrolyte analyzer) will be described. ..
  • the electrolyte analyzer 100 operates the analysis unit 1 for measuring a specific ion concentration in a sample to be analyzed (for example, a patient's sample) and the operation of the entire electrolyte analyzer including the analysis unit 1. It is provided with a control unit 31 (control device) for controlling.
  • the analysis unit 1 includes a sample container 52 that houses the sample to be analyzed, and a plurality of electrode unit units that measure the ion concentration in the sample (in the present embodiment, the first and second electrode unit units 11 and 12). 2), the sample probe 22 that dispenses the sample contained in the sample container 52 into the first and second electrode units 11 and 12, and the comparison electrode that houses the comparative electrode solution.
  • the sample probe 22 is composed of a cover portion 22a provided so as to be rotatable in the horizontal direction around one end, and a probe portion 22b arranged so as to project downward from the other end of the cover portion 22a and extend. ing.
  • the sample probe 22 can be moved in the vertical direction, and the position of the probe portion 22b can be changed by rotating the cover portion 22a, and the sample container 52 and the first and second electrode portions can be moved in the vertical direction.
  • the sample is inserted into the units 11 and 12, and the sample is dispensed (suctioned and discharged) by a pump device (not shown).
  • a pump device not shown.
  • the position of the sample probe 22 the case where the sample is sucked from the sample container 52 is the position 22A, and the sample is dispensed (discharged) to the first electrode unit 11.
  • the case where the sample is dispensed (discharged) to the second electrode unit 12 is shown in parentheses as the position 22B, and the case where the sample is dispensed (discharged) to the second electrode unit 12 is shown in parentheses.
  • the first electrode unit 11 has a diluting tank 23a that dilutes the sample with the diluting liquid sent from the diluting liquid bottle 56a via the flow path, and ions of the diluted sample sent from the diluting tank 23a via the flow path. It has an ion-selective electrode group 24a composed of a plurality of ion-selective electrodes for measuring the concentration, and a comparison electrode 24b with which a comparative solution sent from the comparison electrode liquid bottle 55a via a flow path is in contact.
  • the ion-selective electrode group 24a is composed of a plurality of ion-selective electrodes for measuring ion concentrations such as sodium ion (Na +), potassium ion (K +), calcium ion (Ca ++), and chlor ion (Cl-), respectively. Has been done.
  • the sample probe 22 that sucks the sample contained in the sample container 52 at the position 22A moves to the position 22B and is discharged (dispensed) to the dilution tank 23a.
  • the diluting liquid of the diluting liquid bottle 56a is discharged to the diluting tank 23a via the diluting liquid bottle 56a by the liquid feeding mechanism 58a composed of a valve for opening and closing the flow path and a syringe for sucking and delivering the liquid.
  • the sample is diluted and stirred in the dilution tank 23a.
  • the sample diluted and stirred in the diluting tank 23a (hereinafter referred to as a sample solution) is sucked by the suction device 53a and sent to the ion-selective electrode group 24a via the flow path. Further, the comparative electrode liquid of the comparative electrode liquid bottle 55a is fed to the comparative electrode 24b via the flow path by the liquid feeding mechanism 57a.
  • the ion-selective electrodes and the comparison electrode 24b of the ion-selective electrode group 24a are combined with each other. Is electrically conductive. In this state, the potential difference between the comparative electrode 24b and each ion-selective electrode of the ion-selective electrode group 24a is measured, and the concentration of a specific ion contained in the sample solution is measured based on the obtained potential difference.
  • an ion-sensitive film having a property that the electromotive force changes according to the concentration of a specific ion in the sample solution is attached to each ion-selective electrode of the ion-selective electrode group 24a.
  • the ion-selective electrode outputs an electromotive force according to each ion concentration in the sample solution
  • the electromotive force between each ion-selective electrode of the ion-selective electrode group 24a and the comparative electrode 24b is acquired, and each of them obtains the electromotive force.
  • the ion concentration in the sample is calculated from the electromotive force acquired for the ion.
  • the measurement result is sent to the control unit 31, and is displayed, for example, on a display device (not shown).
  • a display device not shown.
  • the second electrode unit 12 has the same configuration as the first electrode unit 11. That is, the second electrode unit 12 has a diluting tank 23b that dilutes the sample with the diluting liquid sent from the diluting liquid bottle 56b via the flow path, and the diluted sample sent from the diluting tank 23b via the flow path. It has an ion-selective electrode group 24c composed of a plurality of ion-selective electrodes for measuring the ion concentration of the above, and a comparison electrode 24d to which a comparative solution sent from the comparison electrode liquid bottle 55b via a flow path is in contact with the liquid. ..
  • the sample probe 22 that sucks the sample contained in the sample container 52 at the position 22A moves to the position 22C and is discharged (dispensed) to the dilution tank 23b.
  • the diluting liquid of the diluting liquid bottle 56b is discharged to the diluting tank 23b via the diluting liquid bottle 56b by the liquid feeding mechanism 58b composed of a valve for opening and closing the flow path and a syringe for sucking and delivering the liquid.
  • the sample is diluted and stirred in the dilution tank 23b.
  • the sample diluted and stirred in the diluting tank 23b (hereinafter referred to as a sample solution) is sucked by the suction device 53b and sent to the ion-selective electrode group 24c via the flow path. Further, the comparative electrode liquid of the comparative electrode liquid bottle 55b is fed to the comparative electrode 24d via the flow path by the liquid feeding mechanism 57b.
  • each ion-selective electrode and the comparison electrode 24d of the ion-selective electrode group 24c are combined with each other. Is electrically conductive.
  • the potential difference between the comparative electrode 24d and each ion-selective electrode of the ion-selective electrode group 24c can be measured, and the concentration of a specific ion contained in the sample solution can be measured based on the obtained potential difference. ..
  • the measurement result is sent to the control unit 31, and is displayed, for example, on a display device (not shown).
  • the sample solution and the comparative electrode solution in the flow paths of the ion-selective electrode group 24c and the comparative electrode 24d are sucked by the aspirator 53b and discharged to the waste liquid reservoir 54.
  • FIG. 2 to 4 and 7 are top views schematically showing structural examples and arrangement examples of the first and second electrode unit in the analysis unit of the electrolyte analyzer, and FIG. 2 is an ion-selective electrode group.
  • FIG. 3 shows a state in which the cover is attached to the first electrode unit
  • FIG. 3 shows a state in which the ion-selective electrode group cover is removed
  • FIG. 4 shows a state in which the ion-selective electrode group is removed. Indicates that the diluting tank cover has been removed.
  • FIG. 8 is a side view schematically showing a structural example and an arrangement example of the first electrode unit in the analysis unit of the electrolyte analyzer, in which the probe is moved above the diluted layer, and FIG. The state in which the probe descends to the diluted layer is shown.
  • the sample probe 22 that dispenses a sample from the sample container 52 containing the sample to the electrode unit units 11 and 12 rotates and moves around a predetermined position of its longitudinal end as a rotation center axis. , Position 22A, position 22B, and position 22C.
  • the probe portion 22b located at the end opposite to the longitudinal end where the rotation center axis of the sample probe 22 is located accompanies the rotational movement of the sample probe 22.
  • the dilution tanks 23a and 23b are arranged so as to be located along the flow line drawn.
  • the ion-selective electrode groups 24a and 24c and the comparative electrodes 24b and 24d are located below the moving range of the sample probe 22 (that is, the operating range of the cover unit 22a). Is also arranged so as to be located on the outside. Further, the first electrode unit 11 is located closest to the sample container 52 (the position of the probe portion 22b of the sample probe 22 at the position 22A), and the second electrode unit 12 is located farthest from the sample container 52. Each is arranged.
  • the first electrode unit 11 is detachably arranged below the operating range of the sample probe 22 and above the diluting tank 23a with an opening provided for the probe 22b to descend to the diluting tank 23a.
  • the second electrode unit 12 has an opening provided above the dilution tank 23b, the ion-selective electrode group 24c and the comparison electrode 24d so that the probe portion 22c descends to the dilution tank 23b.
  • the first electrode unit 11 has a detachably arranged dilution tank cover 25 (first) having an opening provided for the probe portion 22b to descend to the dilution tank 23a.
  • a dilution tank 23a is provided below the cover), and as shown in FIG. 9, the probe portion 22b descends to the dilution tank 23a to dispense the sample.
  • the ion-selective electrode group cover 26 is attached to the first electrode unit 11 to cover the ion-selective electrode group 24a, and the solenoid lock is placed inside the ion-selective electrode group cover 26 (downward side and ion-selective electrode group 24a side). It has a receiver 26a. Further, a solenoid lock mechanism 11a is provided at a position corresponding to the solenoid lock receiver 26a in the structure of the first electrode unit 11 different from the ion-selective electrode group cover 26.
  • the solenoid lock mechanism 11a moves a part of the ion-selective electrode group cover 26 with respect to the first electrode unit unit 11 by projecting a part thereof based on an electric signal from the control unit 31 and engaging with the solenoid lock receiver 26a. Is restricted and fixed so that it cannot be removed (locked state). Further, the solenoid lock mechanism 11a causes the ion-selective electrode group cover 26 to be the first electrode unit 11 by retracting a part of the protrusion based on the electric signal from the control unit 31 from the solenoid lock receiving 26a side. On the other hand, it is in a removable state (unlocked state).
  • the solenoid lock mechanism 11a and the solenoid lock receiver 26a form an interlock in which the ion-selective electrode group cover 26 (second cover) can be fixed to the electrode unit 11.
  • the ion-selective electrode group cover 26 can be removed from the first electrode unit 11 as shown in FIG. By removing the ion-selective electrode group cover 26, the operator can access the internal components of the first electrode unit 11 such as the ion-selective electrode group 24a and the comparison electrode 24b.
  • the ion-selective electrode group 24a is detachably provided with respect to the first electrode unit 11, and can be removed from the ion-selective electrode group mounting portion 124a by an operator (see FIG. 4).
  • the operator can remove the ion-selective electrode group 24a that needs to be replaced based on the requirements such as the number of times of use, and attach a new ion-selective electrode group 24a to the ion-selective electrode group mounting portion 124a.
  • the ion-selective electrode group 24a can be replaced.
  • the ion-selective electrode group mounting unit 124a has a sensor function for detecting that the ion-selective electrode group 24a is normally mounted, and transmits the detection result to the control unit 31 by an electric signal. do. That is, the control unit 31 has a state in which the ion-selective electrode group 24a is mounted (see FIG. 3) and a state in which the ion-selective electrode group 24a is removed, depending on the detection result of the ion-selective electrode group mounting unit 124a (see FIG. 3). (See FIG. 4) can be determined.
  • the ion-selective electrode group cover mounting sensor that detects that the ion-selective electrode group cover 26 is normally mounted on the first electrode section unit 11 is attached to the first electrode section unit 11.
  • 11c and a lock mechanism operation detection sensor 11b for detecting that the solenoid lock mechanism 11a is operating (locked state) are provided.
  • the ion-selective electrode group cover mounting sensor 11c is, for example, a mechanical sensor that detects an object when pressed, and by arranging it at a position where it is pressed by the solenoid lock receiver 26a, the ion-selective electrode group cover 26 Detects that is mounted in the normal position.
  • the detection result of the ion-selective electrode group cover mounting sensor 11c is sent to the control unit 31 by an electric signal. That is, when the control unit 31 detects that the ion-selective electrode group cover mounting sensor 11c is pressed (see FIG. 2 and the like), the control unit 31 determines that the ion-selective electrode group cover 26 is mounted in a normal position. However, in the case of non-detection in which the pressing is not detected (see FIG. 3 and the like), it can be determined that the ion-selective electrode group cover 26 is not attached (or is not attached in the normal position).
  • the lock mechanism operation detection sensor 11b is, for example, a mechanical sensor that detects an object by being pressed (pushed in), and is arranged at a position where the solenoid lock mechanism 11a is pressed by protruding a part of the solenoid lock mechanism 11a. As a result, it is detected that the solenoid lock mechanism 11a is operating (locked).
  • the detection result of the lock mechanism operation detection sensor 11b is sent to the control unit 31 by an electric signal. That is, when the lock mechanism operation detection sensor 11b is detected to be pressed (see FIG. 2 and the like), the control unit 31 determines that the solenoid lock mechanism 11a is operating (is in a locked state). In the case of non-detection in which the press is not detected (see FIG.
  • FIG. 5 is a flowchart showing the processing contents in the electrolyte analyzer.
  • control unit 31 of the electrolyte analyzer 100 first determines whether or not the ion-selective electrode group 24a of the first electrode unit 11 needs to be replaced (step S100).
  • the necessity of replacement of the ion-selective electrode group 24a is determined by, for example, whether or not the number of times used for the measurement exceeds a predetermined limit number of times.
  • step S110 When the determination result in step S100 is YSE, that is, when it is determined that the ion-selective electrode group 24a needs to be replaced, the measurement process of the first electrode unit 11 is stopped (step S110).
  • the control unit 31 displays and sounds that the ion-selective electrode group 24a of the first electrode unit 11 needs to be replaced and that the measurement process by the first electrode unit 11 has been stopped.
  • step S120 By notifying the operator by such means (step S120) and retracting a protruding part of the solenoid lock mechanism 11a of the first electrode unit 11 from the solenoid lock receiver 26a, the lock is released (interlock release). (Step S130).
  • the ion-selective electrode group cover 26 of the first electrode unit 11 becomes removable, and the operator can access and replace the ion-selective electrode group 24a. Further, since the dilution tank cover 25 located below the movable range of the sample probe 22 is not removed, the sample probe 22 can pass above the first electrode portion unit 11 and the second electrode portion is moving. Dispensing of the sample to the unit 12 can be continued, and the measurement process can be continued. That is, by continuing the measurement process by the second electrode unit 12 without inhibiting the dispensing of the sample by the sample probe 22 into the second electrode unit 12, which does not require replacement of the ion-selective electrode group 24c. The ion-selective electrode group 24a of the first electrode unit 11 can be replaced while suppressing a decrease in processing capacity.
  • step S140 it is determined whether or not the exchange of the ion-selective electrode group 24a by the operator is completed.
  • the normal mounting of the ion-selective electrode group 24a is detected by the ion-selective electrode group mounting unit 124a, and the normal mounting of the ion-selective electrode group cover 26 is the ion-selective electrode group.
  • the cover mounting sensor 11c it is determined that the replacement is completed.
  • step S140 determines whether the exchange of the ion-selective electrode group 24a is not completed. If the determination result in step S140 is NO, that is, if the exchange of the ion-selective electrode group 24a is not completed, the processing of steps S110 to S130 is continued.
  • step S140 If the determination result in step S140 is YES, that is, if it is determined that the exchange of the ion-selective electrode group 24a is completed, then one of the solenoid lock mechanisms 11a of the first electrode unit 11 The portion is projected toward the solenoid receiving 26a to bring it into a locked state (interlock operation) (step S150).
  • step S160 it is determined whether or not the interlock has operated normally.
  • the operation determination of the interlock is performed based on the detection result from the lock mechanism operation detection sensor 11b.
  • step S160 If the determination result in step S160 is NO, the operator is notified of the content instructing the operation confirmation of the interlock by displaying on a display device (not shown) by the control unit 31 or by voice (step S161). The process returns to step S150.
  • step S160 If the determination result in step S160 is YES, the first electrode unit 11 is operated to start the measurement process (step S170), and the process ends.
  • step S200 it is determined whether or not the ion-selective electrode group 24c of the second electrode unit 12 needs to be replaced. If the determination result in step S100 is NO, that is, if it is determined that the ion-selective electrode group 24a does not need to be replaced, the operation of the first electrode unit 11 is continued and the measurement process is performed. continue. That is, the sample probe 22 sucks the sample from the sample container 52 at the position 22A and discharges it to the dilution tank 23a of the first electrode unit 11 or the dilution tank 23b of the second electrode unit 12 at the position 22B or 22C. By doing so, the measurement process by the first electrode unit 11 or the second electrode unit 12 is performed.
  • step S200 When the determination result in step S200 is NO, that is, when it is determined that the ion-selective electrode group 24c does not need to be replaced, the first electrode unit 11 and the second electrode unit 12 are operated. Continue and continue the measurement process. That is, the sample probe 22 sucks the sample from the sample container 52 at the position 22A and discharges it to the dilution tank 23a of the first electrode unit 11 or the dilution tank 23b of the second electrode unit 12 at the position 22B or 22C. By doing so, the measurement process by the first electrode unit 11 or the second electrode unit 12 is performed.
  • step S100 determines whether the ion-selective electrode 24a of the first electrode unit 11 needs to be replaced.
  • the measurement of the first electrode unit 11 is performed.
  • step S110 the determination in step S200 is performed.
  • the determination result in step S200 is YES, that is, when it is determined that the ion-selective electrode group 24c of the second electrode unit 12 needs to be replaced.
  • the second electrode unit 12 The measurement process is stopped (step S210), and thereafter, the same process as the process of steps S120 to S170 for the first electrode unit 11 is performed, and the process is completed.
  • the second electrode unit 12 has a solenoid lock mechanism 11a, a lock mechanism operation detection sensor 11b, and ion selectivity of the first electrode unit 11 shown in FIGS. 2 to 4 and 7. It has a configuration corresponding to each of the electrode group cover mounting sensor 11c and the solenoid lock receiver 26a, and the processing of steps S220 to S270 is performed using these, and the processing is completed.
  • the second electrode unit 11 in the state where it is not necessary to replace the ion-selective electrode 24c of the second electrode unit 12, the second electrode unit 11 is in operation during the second period.
  • the electrode unit 12 of the above is also operating, and the second electrode unit 12 is operating even during the period when the first electrode unit 11 is stopped.
  • the diluting tanks 23a and 23b for diluting the sample dispensed by the sample probe 22 and the ion for measuring a specific ion concentration in the sample diluted in the diluting tanks 23a and 23b are provided, and the first electrode unit 11 is below the operating range of the sample probe 22.
  • the processing capacity can be increased.
  • the ion-selective electrode group 24a can be replaced while suppressing the decrease.
  • the measurement process cannot be performed during the replacement of the ion-selective electrode group 24a, but the sample is dispensed into the diluting tank 23a and the sample is diluted / stirred in the diluting tank 23a. Can be continued.
  • This embodiment illustrates a case where the second electrode unit 12B of the analysis unit 1B of the electrolyte analyzer 100B has a dilution tank cover 28 and an ion-selective electrode group cover 29.
  • FIG. 6 is a top view schematically showing a structural example and an arrangement example of the first and second electrode unit in the analysis unit of the electrolyte analyzer of the present embodiment.
  • the same members as those in the first embodiment are designated by the same reference numerals, and the description thereof will be omitted.
  • the first and second electrode unit units 11 and 12B are the flow lines of the sample probe 22 for dispensing the sample from the sample container 52 containing the sample to the electrode units 11 and 12B (accurately). Is arranged so that the dilution tanks 23a and 23b are located along the flow line of the probe portion 22b). Further, in the first and second electrode unit units 11 and 12B, the ion-selective electrode groups 24a and 24c and the comparative electrodes 24b and 24d are located below the moving range of the sample probe 22 (that is, the operating range of the cover unit 22a). Is also arranged so as to be located on the outside. Further, the first electrode unit 11 is located closest to the sample container 52 (the position of the probe portion 22b of the sample probe 22 at the position 22A), and the second electrode unit 12B is located farthest from the sample container 52. Each is arranged.
  • the second electrode unit 12B is a detachably arranged diluting unit having an opening provided for the probe unit 22c to descend to the diluting tank 23b above the diluting tank 23b below the operating range of the sample probe 22.
  • the ion-selective electrode group 24c and the ion-selective electrode group 24c are detachably arranged so as to cover the upper part of the ion-selective electrode group 24c and the comparison electrode 24d in a range not below the operating range of the tank cover 28 (first cover) and the sample probe 22. It has a cover 29 (second cover).
  • the ion-selective electrode group cover 29 has a solenoid lock receiver 29a similar to the ion-selective electrode group cover 26. Further, the second electrode unit 12B has the same solenoid lock mechanism 12a as the first electrode unit 11. That is, the solenoid lock mechanism 12a and the solenoid lock receiver 29a form an interlock capable of fixing the ion-selective electrode group cover 29 (second cover) to the second electrode unit 12B.
  • the ion-selective electrode group cover mounting sensor that detects that the ion-selective electrode group cover 29 is normally mounted on the second electrode unit 12B is mounted on the second electrode unit 12B.
  • 12c and a lock mechanism operation detection sensor 12b for detecting that the solenoid lock mechanism 12a is operating (locked state) are provided.
  • first electrode unit 11 can be stopped and the second electrode unit 12B can continue to operate as in the first embodiment.
  • the measurement process cannot be performed during the replacement of the ion-selective electrode group 24c, but the sample is dispensed into the diluting tank 23b and the sample is diluted / stirred in the diluting tank 23b. Can be continued. Further, in the same procedure as the procedure for removing the second cover 26 of the first electrode unit shown in the first embodiment, the second cover 29 of the second electrode unit is placed below the probe portion 22b. Is not placed and does not interfere, so it can be removed independently.
  • the second covers 26 and 29 are removable in the first electrode unit 11 and the second electrode unit 12B has been described as an example.
  • the second covers 26 and 29 may be connected to the first electrode unit 11 and the second electrode unit 12B via a hinge mechanism or the like so as to be openable and closable.
  • the present invention is not limited to this, and for example, three or more electrode unit units are provided and the sample container 52 is provided.
  • the electrode unit located closest to the sample container 52 has a first cover and a second cover, and the electrode unit located farthest from the sample container 52 has a third cover. It may be configured.
  • the ion-selective electrode group cover mounting sensor 11c and the lock mechanism operation detection sensor 11b are mechanical sensors
  • the present invention is not limited to this, for example.
  • a laser type sensor or a sensor that makes a determination based on a camera image may be used.
  • the sensor function of the ion-selective electrode group mounting unit 124a and the ion-selective electrode group cover mounting sensor 11c determine whether or not the replacement of the ion-selective electrode group is completed.
  • the case where the replacement is performed based on the detection result of the above has been described as an example, but the present invention is not limited to this. It may be determined that the replacement of the sex electrode group is completed. However, even in this case as well, it is determined whether or not the ion-selective electrode group has been normally replaced based on the sensor function of the ion-selective electrode group mounting unit 124a and the detection result of the ion-selective electrode group cover mounting sensor 11c. Is preferable. Further, the operator may read an individual identification marker such as a bar code provided on the ion-selective electrode group to confirm that the electrode has been replaced with a new ion-selective electrode. good.
  • the present invention is not limited to the one including all the configurations described in the above-described embodiment, and includes the one in which a part of the configurations is deleted. Further, each of the above configurations, functions and the like may be realized by designing a part or all of them by, for example, an integrated circuit. Further, each of the above configurations, functions, and the like may be realized by software by the processor interpreting and executing a program that realizes each function.

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PCT/JP2021/007995 2020-07-31 2021-03-02 電解質分析装置 WO2022024433A1 (ja)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0466573U (enrdf_load_stackoverflow) * 1990-10-19 1992-06-11
JPH06273372A (ja) * 1993-03-18 1994-09-30 Hitachi Ltd 生体液分析装置
JP2000266757A (ja) * 1999-03-18 2000-09-29 Hitachi Ltd 自動分析装置
JP3107751U (ja) * 2004-09-15 2005-02-17 株式会社日立ハイテクノロジーズ 駆動部分離型可動蓋及びそれを備えた電解質測定装置
JP2017156089A (ja) * 2016-02-29 2017-09-07 株式会社日立ハイテクノロジーズ 電解質分析装置

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JP2017156089A (ja) * 2016-02-29 2017-09-07 株式会社日立ハイテクノロジーズ 電解質分析装置

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