WO2021116055A1 - New methylquinazolinone derivatives - Google Patents

New methylquinazolinone derivatives Download PDF

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Publication number
WO2021116055A1
WO2021116055A1 PCT/EP2020/084976 EP2020084976W WO2021116055A1 WO 2021116055 A1 WO2021116055 A1 WO 2021116055A1 EP 2020084976 W EP2020084976 W EP 2020084976W WO 2021116055 A1 WO2021116055 A1 WO 2021116055A1
Authority
WO
WIPO (PCT)
Prior art keywords
compound
formula
cancer
braf
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2020/084976
Other languages
English (en)
French (fr)
Inventor
Cosimo Dolente
David Stephen HEWINGS
Daniel Hunziker
Daniela Krummenacher
Piergiorgio Francesco Tommaso PETTAZZONI
Juergen Wichmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Hoffmann La Roche Inc
Original Assignee
F Hoffmann La Roche AG
Hoffmann La Roche Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP20817377.3A priority Critical patent/EP4073065B1/en
Priority to CR20220251A priority patent/CR20220251A/es
Priority to BR112022011123-1A priority patent/BR112022011123B1/pt
Priority to JP2021566023A priority patent/JP7108146B2/ja
Priority to CN202080084994.3A priority patent/CN114787156B/zh
Priority to IL316473A priority patent/IL316473A/en
Priority to EP24205932.7A priority patent/EP4483882A3/en
Priority to NZ787393A priority patent/NZ787393B2/en
Priority to MA58087A priority patent/MA58087B1/fr
Priority to AU2020403443A priority patent/AU2020403443B2/en
Priority to PE2022000853A priority patent/PE20221778A1/es
Priority to PL20817377.3T priority patent/PL4073065T3/pl
Priority to RS20250354A priority patent/RS66721B1/sr
Priority to FIEP20817377.3T priority patent/FI4073065T3/fi
Priority to CA3162883A priority patent/CA3162883C/en
Priority to CN202410878222.7A priority patent/CN118791472A/zh
Priority to UAA202202163A priority patent/UA128299C2/uk
Application filed by F Hoffmann La Roche AG, Hoffmann La Roche Inc filed Critical F Hoffmann La Roche AG
Priority to PH1/2022/551119A priority patent/PH12022551119A1/en
Priority to KR1020227023074A priority patent/KR102836833B1/ko
Priority to HRP20250418TT priority patent/HRP20250418T1/hr
Priority to DK20817377.3T priority patent/DK4073065T3/da
Priority to LTEPPCT/EP2020/084976T priority patent/LT4073065T/lt
Priority to IL292161A priority patent/IL292161B2/en
Priority to SI202030605T priority patent/SI4073065T1/sl
Priority to ES20817377T priority patent/ES3023264T3/es
Priority to MX2022006783A priority patent/MX2022006783A/es
Publication of WO2021116055A1 publication Critical patent/WO2021116055A1/en
Priority to JP2021202780A priority patent/JP7802514B2/ja
Priority to ZA2022/04675A priority patent/ZA202204675B/en
Priority to US17/835,245 priority patent/US12116349B2/en
Anticipated expiration legal-status Critical
Priority to CONC2022/0008968A priority patent/CO2022008968A2/es
Priority to US18/525,536 priority patent/US20240174621A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms

Definitions

  • the compound of formula (I) in this invention may be derivatised at functional groups to provide derivatives which are capable of conversion back to the parent compound in vivo.
  • the invention thus also relates to a process for the preparation of a compound according to the invention, comprising the reaction of a compound of formula (B1) with a compound of formula (B2) in the presence of a base.
  • the invention includes all substituents in their corresponding deuterated form, wherever applicable, of the compound of formula (I).
  • racemic mixtures of the compound of the invention may be separated so that the individual enantiomers are isolated.
  • the separation can be carried out by methods well known in the art, such as the coupling of a racemic mixture of compounds to an enantiomerically pure compound to form a diastereomeric mixture, followed by separation of the individual diastereomers by standard methods, such as fractional crystallization or chromatography.
  • A375 and HCT116 cell lines are maintained in DMEM no-phenol red medium supplemented with 10% fetal bovine serum (FBS).
  • FBS fetal bovine serum
  • P-ERK levels are determined by measuring FRET fluorescence signal induced by selective binding of 2 antibodies provided in the mentioned kit (Cisbio cat# 64AERPEH) on ERK protein when phosphorylated at Thr202/Tyr204.
  • the plate is then centrifuged at 300 ref for 30 second, sealed to prevent evaporation and incubated overnight in the dark at room temperature.
  • the Percentage of Maximum paradox inducing effect from dabrafenib is determined by evaluating the percentage at which the test compound induce its maximum P-ERK signal as percentage of the highest signal produced by dabrafenib within the dose range tested.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Combines (AREA)
  • Harvester Elements (AREA)
PCT/EP2020/084976 2019-12-10 2020-12-08 New methylquinazolinone derivatives Ceased WO2021116055A1 (en)

Priority Applications (31)

Application Number Priority Date Filing Date Title
UAA202202163A UA128299C2 (uk) 2019-12-10 2020-12-08 Нові похідні метилхіназолінону
BR112022011123-1A BR112022011123B1 (pt) 2019-12-10 2020-12-08 Composto, processo para a preparação de um composto, composição farmacêutica e uso de um composto
JP2021566023A JP7108146B2 (ja) 2019-12-10 2020-12-08 新規メチルキナゾリノン誘導体
CN202080084994.3A CN114787156B (zh) 2019-12-10 2020-12-08 新颖甲基喹唑啉酮衍生物
IL316473A IL316473A (en) 2019-12-10 2020-12-08 New methylquinazolinone derivatives
EP24205932.7A EP4483882A3 (en) 2019-12-10 2020-12-08 New methylquinazolinone derivatives
NZ787393A NZ787393B2 (en) 2020-12-08 New methylquinazolinone derivatives
MA58087A MA58087B1 (fr) 2019-12-10 2020-12-08 Nouveaux dérivés de méthylquinazolinone
AU2020403443A AU2020403443B2 (en) 2019-12-10 2020-12-08 New methylquinazolinone derivatives
PE2022000853A PE20221778A1 (es) 2019-12-10 2020-12-08 Nuevos derivados de metilquinazolinona
PL20817377.3T PL4073065T3 (pl) 2019-12-10 2020-12-08 Nowe pochodne metylochinazolinonu
RS20250354A RS66721B1 (sr) 2019-12-10 2020-12-08 Novi derivati metilhinazolinona
FIEP20817377.3T FI4073065T3 (fi) 2019-12-10 2020-12-08 Uusia metyylikinatsolinonijohdannaisia
CA3162883A CA3162883C (en) 2019-12-10 2020-12-08 (3r)-and (3s)-n-[2-cyano-4-fluoro-3-(3-methyl-4-oxo-quinazolin-6-yl)oxy-phenyl]-3-fluoro-pyrrolidine-1-sulfonamide compounds and their use as braf inhibitors
CN202410878222.7A CN118791472A (zh) 2019-12-10 2020-12-08 新颖甲基喹唑啉酮衍生物
EP20817377.3A EP4073065B1 (en) 2019-12-10 2020-12-08 New methylquinazolinone derivatives
CR20220251A CR20220251A (es) 2019-12-10 2020-12-08 Nuevos derivados de metilquinazolinona
PH1/2022/551119A PH12022551119A1 (en) 2019-12-10 2020-12-08 New methylquinazolinone derivatives
KR1020227023074A KR102836833B1 (ko) 2019-12-10 2020-12-08 신규 메틸퀴나졸리논 유도체
HRP20250418TT HRP20250418T1 (hr) 2019-12-10 2020-12-08 Novi derivati metil-kinazolinona
DK20817377.3T DK4073065T3 (da) 2019-12-10 2020-12-08 Hidtil ukendte methylquinazolinonderivativer
LTEPPCT/EP2020/084976T LT4073065T (lt) 2019-12-10 2020-12-08 Nauji metilchinazolinono dariniai
IL292161A IL292161B2 (en) 2019-12-10 2020-12-08 New methylquinazolinone derivatives
SI202030605T SI4073065T1 (sl) 2019-12-10 2020-12-08 Novi derivati metilkinazolinona
ES20817377T ES3023264T3 (en) 2019-12-10 2020-12-08 New methylquinazolinone derivatives
MX2022006783A MX2022006783A (es) 2019-12-10 2020-12-08 Nuevos derivados de metilquinazolinona.
JP2021202780A JP7802514B2 (ja) 2019-12-10 2021-12-14 新規メチルキナゾリノン誘導体
ZA2022/04675A ZA202204675B (en) 2019-12-10 2022-04-26 New methylquinazolinone derivatives
US17/835,245 US12116349B2 (en) 2019-12-10 2022-06-08 Methylquinazolinone derivatives
CONC2022/0008968A CO2022008968A2 (es) 2019-12-10 2022-06-28 Nuevos derivados de metilquinazolinona
US18/525,536 US20240174621A1 (en) 2019-12-10 2023-11-30 Methylquinazolinone derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19214941.7 2019-12-10
EP19214941 2019-12-10

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US17/835,245 Continuation US12116349B2 (en) 2019-12-10 2022-06-08 Methylquinazolinone derivatives

Publications (1)

Publication Number Publication Date
WO2021116055A1 true WO2021116055A1 (en) 2021-06-17

Family

ID=68848113

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2020/084976 Ceased WO2021116055A1 (en) 2019-12-10 2020-12-08 New methylquinazolinone derivatives

Country Status (29)

Country Link
US (2) US12116349B2 (https=)
EP (2) EP4483882A3 (https=)
JP (2) JP7108146B2 (https=)
KR (1) KR102836833B1 (https=)
CN (2) CN114787156B (https=)
AR (1) AR122351A1 (https=)
AU (1) AU2020403443B2 (https=)
CL (1) CL2022001529A1 (https=)
CO (1) CO2022008968A2 (https=)
CR (1) CR20220251A (https=)
DK (1) DK4073065T3 (https=)
ES (1) ES3023264T3 (https=)
FI (1) FI4073065T3 (https=)
HR (1) HRP20250418T1 (https=)
HU (1) HUE071148T2 (https=)
IL (2) IL316473A (https=)
LT (1) LT4073065T (https=)
MA (1) MA58087B1 (https=)
MX (1) MX2022006783A (https=)
PE (1) PE20221778A1 (https=)
PH (1) PH12022551119A1 (https=)
PL (1) PL4073065T3 (https=)
PT (1) PT4073065T (https=)
RS (1) RS66721B1 (https=)
SI (1) SI4073065T1 (https=)
TW (2) TWI877268B (https=)
UA (1) UA128299C2 (https=)
WO (1) WO2021116055A1 (https=)
ZA (2) ZA202204675B (https=)

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WO2022258612A1 (en) * 2021-06-09 2022-12-15 F. Hoffmann-La Roche Ag Combination therapy for cancer treatment
WO2022261250A1 (en) 2021-06-08 2022-12-15 C4 Therapeutics, Inc. Therapeutics for the degradation of mutant braf
WO2022258600A1 (en) * 2021-06-09 2022-12-15 F. Hoffmann-La Roche Ag Combination of a particular braf inhibitor (paradox breaker) and a pd-1 axis binding antagonist for use in the treatment of cancer
WO2023008462A1 (ja) 2021-07-27 2023-02-02 東レ株式会社 癌の治療及び／又は予防のための医薬品
WO2023078881A1 (en) 2021-11-04 2023-05-11 F. Hoffmann-La Roche Ag Novel use of quinazolinone compound for the treatment of cancer
WO2024017294A1 (zh) 2022-07-19 2024-01-25 西藏海思科制药有限公司 作为激酶抑制剂的喹唑啉酮衍生物的制备及其用途
WO2024105144A1 (en) 2022-11-18 2024-05-23 F. Hoffmann-La Roche Ag Quinazolinone compound as braf inhibitor for the treatment of advanced solid cancer or metastases
WO2024126634A1 (en) * 2022-12-15 2024-06-20 F. Hoffmann-La Roche Ag Process for the preparation of a quinazolinone derivative
WO2024126660A1 (en) * 2022-12-15 2024-06-20 F. Hoffmann-La Roche Ag Combination therapy for cancer treatment
US12116349B2 (en) 2019-12-10 2024-10-15 Hoffmann-La Roche Inc. Methylquinazolinone derivatives
WO2025008313A1 (en) 2023-07-04 2025-01-09 F. Hoffmann-La Roche Ag New solid forms of (3r)-n-[2-cyano-4-fluoro-3-(3-methyl-4-oxo-quinazolin-6-yl)oxy-phenyl]- 3-fluoro-pyrrolidine-1-sulfonamide
US12303509B2 (en) 2020-06-09 2025-05-20 Pfizer Inc. Compounds for the treatment of BRAF-associated diseases and disorders
WO2025108405A1 (zh) * 2023-11-22 2025-05-30 西藏海思科制药有限公司 作为激酶抑制剂的喹唑啉酮衍生物的制备及其用途
WO2026037755A1 (en) 2024-08-13 2026-02-19 F. Hoffmann-La Roche Ag New methylquinazolinone derivatives
WO2026046946A1 (en) 2024-08-28 2026-03-05 F. Hoffmann-La Roche Ag New solid forms of (3r)-n-[2-cyano-4-fluoro-3-(3-methyl-4-oxo-quinazolin-6-yl)oxy-phenyl]-3-fluoro-pyrrolidine-1-sulfonamide

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AU2020403082A1 (en) * 2019-12-10 2022-05-12 F. Hoffmann-La Roche Ag New BRAF inhibitors as paradox breakers
TW202545530A (zh) * 2024-01-17 2025-12-01 大陸商海思科醫藥集團股份有限公司 含ｂｒａｆ抑制劑的藥物組合物及其在醫藥上的應用

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Cited By (18)

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Publication number Priority date Publication date Assignee Title
US12116349B2 (en) 2019-12-10 2024-10-15 Hoffmann-La Roche Inc. Methylquinazolinone derivatives
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