KR102836833B1 - 신규 메틸퀴나졸리논 유도체 - Google Patents

신규 메틸퀴나졸리논 유도체

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Publication number
KR102836833B1
KR102836833B1 KR1020227023074A KR20227023074A KR102836833B1 KR 102836833 B1 KR102836833 B1 KR 102836833B1 KR 1020227023074 A KR1020227023074 A KR 1020227023074A KR 20227023074 A KR20227023074 A KR 20227023074A KR 102836833 B1 KR102836833 B1 KR 102836833B1
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KR
South Korea
Prior art keywords
compound
formula
cancer
braf
pharmaceutically acceptable
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KR1020227023074A
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English (en)
Korean (ko)
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KR20220110554A (ko
Inventor
코시모 돌렌테
다비드 스테판 헤빙스
다니엘 훈지커
다니엘라 크루메나처
피에르기오르기오 프란세스코 토마소 펫타쪼니
위르겐 비흐만
Original Assignee
에프. 호프만-라 로슈 아게
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Publication of KR20220110554A publication Critical patent/KR20220110554A/ko
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Combines (AREA)
  • Harvester Elements (AREA)
KR1020227023074A 2019-12-10 2020-12-08 신규 메틸퀴나졸리논 유도체 Active KR102836833B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19214941.7 2019-12-10
EP19214941 2019-12-10
PCT/EP2020/084976 WO2021116055A1 (en) 2019-12-10 2020-12-08 New methylquinazolinone derivatives

Publications (2)

Publication Number Publication Date
KR20220110554A KR20220110554A (ko) 2022-08-08
KR102836833B1 true KR102836833B1 (ko) 2025-07-22

Family

ID=68848113

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020227023074A Active KR102836833B1 (ko) 2019-12-10 2020-12-08 신규 메틸퀴나졸리논 유도체

Country Status (29)

Country Link
US (2) US12116349B2 (https=)
EP (2) EP4483882A3 (https=)
JP (2) JP7108146B2 (https=)
KR (1) KR102836833B1 (https=)
CN (2) CN114787156B (https=)
AR (1) AR122351A1 (https=)
AU (1) AU2020403443B2 (https=)
CL (1) CL2022001529A1 (https=)
CO (1) CO2022008968A2 (https=)
CR (1) CR20220251A (https=)
DK (1) DK4073065T3 (https=)
ES (1) ES3023264T3 (https=)
FI (1) FI4073065T3 (https=)
HR (1) HRP20250418T1 (https=)
HU (1) HUE071148T2 (https=)
IL (2) IL316473A (https=)
LT (1) LT4073065T (https=)
MA (1) MA58087B1 (https=)
MX (1) MX2022006783A (https=)
PE (1) PE20221778A1 (https=)
PH (1) PH12022551119A1 (https=)
PL (1) PL4073065T3 (https=)
PT (1) PT4073065T (https=)
RS (1) RS66721B1 (https=)
SI (1) SI4073065T1 (https=)
TW (2) TWI877268B (https=)
UA (1) UA128299C2 (https=)
WO (1) WO2021116055A1 (https=)
ZA (2) ZA202204675B (https=)

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AU2020403082A1 (en) * 2019-12-10 2022-05-12 F. Hoffmann-La Roche Ag New BRAF inhibitors as paradox breakers
PH12022551119A1 (en) 2019-12-10 2023-08-23 Hoffmann La Roche New methylquinazolinone derivatives
TW202426436A (zh) 2020-06-09 2024-07-01 美商艾瑞生藥股份有限公司 用於治療ｂｒａｆ相關的疾病和病症之化合物
MX2023014059A (es) 2021-06-08 2024-03-12 C4 Therapeutics Inc Terapeuticos para la degradacion de una proteina quiinasa de serina/ treonina mutante.
IL307964A (en) * 2021-06-09 2023-12-01 Chugai Pharmaceutical Co Ltd Combined treatment for cancer
CA3216220A1 (en) * 2021-06-09 2022-12-15 F. Hoffmann-La Roche Ag Combination of a particular braf inhibitor (paradox breaker) and a pd-1 axis binding antagonist for use in the treatment of cancer
MX2023014629A (es) * 2021-06-09 2024-01-30 Hoffmann La Roche Nuevas formas solidas de (3r)-n-[2-ciano-4-fluoro-3-(3-metil-4-oxo -quinazolin-6-il)oxi-fenil]-3-fluoro-pirrolidin-1-sulfonamida.
KR20240041917A (ko) 2021-07-27 2024-04-01 도레이 카부시키가이샤 암의 치료 및/또는 예방을 위한 의약품
EP4426305A1 (en) 2021-11-04 2024-09-11 F. Hoffmann-La Roche AG Novel use of quinazolinone compound for the treatment of cancer
TW202409040A (zh) 2022-07-19 2024-03-01 大陸商西藏海思科製藥有限公司 作為激酶抑制劑的喹唑啉酮衍生物的製備及其用途
EP4618994A1 (en) 2022-11-18 2025-09-24 F. Hoffmann-La Roche AG Quinazolinone compound as braf inhibitor for the treatment of advanced solid cancer or metastases
WO2024126660A1 (en) * 2022-12-15 2024-06-20 F. Hoffmann-La Roche Ag Combination therapy for cancer treatment
TW202438072A (zh) * 2022-12-15 2024-10-01 瑞士商赫孚孟拉羅股份公司 製備喹唑啉酮衍生物之方法
KR20260032991A (ko) 2023-07-04 2026-03-10 에프. 호프만-라 로슈 아게 (3r)-n-[2-시아노-4-플루오로-3-(3-메틸-4-옥소-퀴나졸린-6-일)옥시-페닐]-3-플루오로-피롤리딘-1-설폰아미드의신규 고체 형태
WO2025108405A1 (zh) * 2023-11-22 2025-05-30 西藏海思科制药有限公司 作为激酶抑制剂的喹唑啉酮衍生物的制备及其用途
TW202545530A (zh) * 2024-01-17 2025-12-01 大陸商海思科醫藥集團股份有限公司 含ｂｒａｆ抑制劑的藥物組合物及其在醫藥上的應用
WO2026037755A1 (en) 2024-08-13 2026-02-19 F. Hoffmann-La Roche Ag New methylquinazolinone derivatives
WO2026046946A1 (en) 2024-08-28 2026-03-05 F. Hoffmann-La Roche Ag New solid forms of (3r)-n-[2-cyano-4-fluoro-3-(3-methyl-4-oxo-quinazolin-6-yl)oxy-phenyl]-3-fluoro-pyrrolidine-1-sulfonamide

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GB0525068D0 (en) 2005-12-08 2006-01-18 Novartis Ag Organic compounds
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EP3147281A1 (en) 2008-03-17 2017-03-29 Ambit Biosciences Corporation Quinazoline derivatives as raf kinase modulators and methods of use thereof
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
TW201041888A (en) 2009-05-06 2010-12-01 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
AR091876A1 (es) 2012-07-26 2015-03-04 Novartis Ag Combinaciones farmaceuticas para el tratamiento de enfermedades proliferativas
AU2013318283A1 (en) 2012-09-19 2015-03-05 Novartis Ag Dihydropyrrolidino-pyrimidines as kinase inhibitors
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RU2687107C1 (ru) 2018-06-18 2019-05-07 федеральное государственное автономное образовательное учреждение высшего образования "Московский физико-технический институт (государственный университет)" Ингибитор braf киназы n-(3-(5-(4-хлорофенил)-1h-пиразоло[3,4-b]пиридин-3-карбонил)-2,4-дифторофенил) пропан-1-сульфонамид
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AU2020403082A1 (en) * 2019-12-10 2022-05-12 F. Hoffmann-La Roche Ag New BRAF inhibitors as paradox breakers
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TW202426436A (zh) 2020-06-09 2024-07-01 美商艾瑞生藥股份有限公司 用於治療ｂｒａｆ相關的疾病和病症之化合物
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Also Published As

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UA128299C2 (uk) 2024-05-29
JP7108146B2 (ja) 2022-07-27
BR112022011123A2 (pt) 2022-08-23
EP4483882A2 (en) 2025-01-01
FI4073065T3 (fi) 2025-04-16
SI4073065T1 (sl) 2025-06-30
PL4073065T3 (pl) 2025-05-19
PT4073065T (pt) 2025-04-15
JP2022531609A (ja) 2022-07-07
AR122351A1 (es) 2022-09-07
US20240174621A1 (en) 2024-05-30
MA58087B1 (fr) 2025-04-30
DK4073065T3 (da) 2025-04-22
PH12022551119A1 (en) 2023-08-23
WO2021116055A1 (en) 2021-06-17
JP2022124458A (ja) 2022-08-25
RS66721B1 (sr) 2025-05-30
TWI877268B (zh) 2025-03-21
US20220298119A1 (en) 2022-09-22
AU2020403443A1 (en) 2022-05-12
CA3162883A1 (en) 2021-06-17
HRP20250418T1 (hr) 2025-06-06
CN118791472A (zh) 2024-10-18
PE20221778A1 (es) 2022-11-16
CL2022001529A1 (es) 2023-02-10
JP7802514B2 (ja) 2026-01-20
TWI908405B (zh) 2025-12-11
CN114787156A (zh) 2022-07-22
ZA202204675B (en) 2022-12-21
IL316473A (en) 2024-12-01
TW202504895A (zh) 2025-02-01
AU2020403443B2 (en) 2023-02-23
KR20220110554A (ko) 2022-08-08
CO2022008968A2 (es) 2022-07-19
US12116349B2 (en) 2024-10-15
EP4073065B1 (en) 2025-02-19
LT4073065T (lt) 2025-04-25
MX2022006783A (es) 2022-07-11
EP4073065A1 (en) 2022-10-19
TW202136245A (zh) 2021-10-01
CR20220251A (es) 2022-07-11
CN114787156B (zh) 2024-07-26
ZA202206923B (en) 2024-10-30
ES3023264T3 (en) 2025-05-30
IL292161B2 (en) 2025-04-01
NZ787393A (en) 2025-07-25
IL292161B1 (en) 2024-12-01
HUE071148T2 (hu) 2025-08-28
IL292161A (en) 2022-06-01
EP4483882A3 (en) 2025-03-05

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