WO2021097609A1 - Sample analyzer and sample analysis method - Google Patents

Abstract

A sample analyzer, comprising: a sampling allocation module (10), which comprises a sampler (11), a blood separation valve (12), and a first power device (13), wherein the sampler (11) collects a blood sample, the first power device (13) draws the blood sample collected by the sampler (11) into the blood separation valve (11), and the blood separation valve (11) allocates the blood sample into a first part blood sample and a second part blood sample; an erythrocyte sedimentation rate detection module (20), which provides a detection place for the first part blood sample, and performs light irradiation and detects the degree of absorption or scattering of light by the first part blood sample so as to obtain the erythrocyte sedimentation rate of the first part blood sample; and a routine blood detection module (30), which performs routine blood detection on the second part blood sample. Since the erythrocyte sedimentation rate detection module (20) and the routine blood detection module (30) are allocated different parts of the same blood sample, the erythrocyte sedimentation rate detection module (20) and the routine blood detection module (30) may separately perform parallel detection, and the overall detection time is short, thereby improving the detection efficiency.

Description

Sample analyzer and sample analysis method Technical field

This application relates to the field of medical equipment, in particular to a sample analyzer and a sample analysis method.

Background technique

In the blood in the body, the red blood cells are dispersed and suspended due to the flow of blood and the mutual repulsion of the negative charges on the surface of the red blood cells. When the isolated blood is left standing, the red blood cells will sink due to gravity. When in a pathological state, the type and content of the protein in the plasma will change, which will change the charge balance in the blood, reduce the negative charge on the surface of the red blood cells, and then make the red blood cells form a money-like shape and accelerate the sedimentation. Therefore, the rate of red blood cell sedimentation within 1 hour, that is, the Erythrocyte Sedimentation Rate (ESR), can be used to assist in disease assessment.

Although ESR is not sensitive and specific in diagnosis, it is still considered to be a reliable and indirect acute-phase inflammatory response factor. ESR is widely used in the treatment and monitoring of infectious diseases, acute and chronic inflammation, rheumatism, connective tissue diseases, cancer and Hodgkin's disease.

In the application scenario of blood in clinical testing, blood routine is also an indispensable test index. Therefore, there is a need for an all-in-one machine that can detect both ESR and blood routine, so as to meet the clinical needs for blood testing.

This kind of all-in-one machine generally connects the ESR detection module and the blood routine detection module in series through the pipeline. The blood sample first flows through the ESR detection module. After the ESR is detected, this part of the blood sample flows to the blood routine detection module to test the blood routine. . However, this all-in-one machine can only test blood routine after the ESR test is completed, and the test speed is slow.

Summary of the invention

In order to solve the above technical problems, an embodiment of the present application provides a sample analyzer, including:

The sampling distribution module includes a sampler, a blood separation valve, and a first power device. The sampler is used to collect blood samples. The blood separation valve is connected to the sampler through a front pipeline and is connected to the first power device through a rear pipeline. A power device is connected. The first power device is used to drive the sampler to collect blood samples and draw the collected blood samples into the blood separation valve through the front pipeline, wherein the blood separation valve is used To divide the blood sample into a first part of blood sample and a second part of blood sample;

The erythrocyte sedimentation rate detection module includes a detection pipeline and an optical detection device, the detection pipeline is connected to the blood separation valve and is used to provide a detection place for the first part of the blood sample distributed by the blood separation valve, the optical detection device Used to irradiate the first part of the blood sample in the detection tube with light and detect the degree of absorption or scattering of light by the first part of the blood sample in the detection tube to obtain the red blood cell sedimentation rate of the first part of the blood sample ；

The blood routine detection module includes a blood routine detection pool and a blood routine detection device. The blood routine detection pool is connected to the blood separation valve and is used to provide a testing place for the second part of blood samples distributed by the blood separation valve. The blood routine detection device is used to perform blood routine detection on the second part of blood samples in the blood routine detection pool.

In one embodiment, the time for the erythrocyte sedimentation rate detection module to detect the erythrocyte sedimentation rate of the first part of the blood sample overlaps with the time for the blood routine detection module to detect the blood routine parameter of the second part of the blood sample.

In one embodiment, the blood separation valve includes:

A liquid inlet connected to the sampler through the front pipeline, and the first power device drives the blood sample collected by the sampler to flow into the blood separation valve through the liquid inlet;

A first liquid separation port connected to the detection pipeline, and the first liquid separation opening is used for the first part of the blood sample distributed by the blood separation valve to flow into the detection pipeline;

A second liquid separation port connected to the routine blood detection pool, and the second liquid separation opening is used for the second part of blood sample distributed by the blood separation valve to flow into the routine blood detection pool;

The liquid outlet is connected to the first power device through the rear pipeline, and the first power device drives the blood sample in the blood separation valve to flow from the liquid outlet into the rear pipeline .

In one embodiment, the erythrocyte sedimentation rate detection module further includes an erythrocyte sedimentation rate detection pool independent of the routine blood sedimentation pool, the detection pipeline is connected to the blood separation valve through the erythrocyte sedimentation rate detection pool, and the erythrocyte sedimentation rate detection The pool is used to receive the first part of blood sample distributed by the blood separation valve.

In an embodiment, the erythrocyte sedimentation rate detection module further includes a second power device connected to the detection pipeline, and the second power device is used to drive the first part of the blood sample distributed by the blood separation valve Flow into the detection pipeline, and make the first part of blood sample flow to the detection area in the detection pipeline, stop moving and keep it still, so that the optical detection device can detect the first part of the blood sample. The erythrocyte sedimentation rate is tested.

In one embodiment, a part of the rear pipeline is the detection pipeline, wherein the first power device is used to draw the blood sample collected by the sampler into the blood separation valve until the A part of the blood sample flows into the detection line of the back line.

In one embodiment, the optical detection device includes:

A light emitter, the light emitter is located at one side of the detection area of the detection pipeline, and is used to irradiate the first part of the blood sample in the detection area,

A light receiver, which is located at one side of the detection area of the detection pipeline, and is used to detect the amount of change of the light emitted by the light emitter after irradiating the first part of the blood sample.

In one embodiment, the detection pipeline is arranged horizontally.

In an embodiment, the sample analyzer further includes a liquid path support module for providing liquid path support for the sample distribution module, the erythrocyte sedimentation rate detection module, and the blood routine detection module.

An embodiment of the present application also provides a sample analysis method, including:

Sampling distribution step: the first power device drives the sampler to collect blood samples and draws the blood samples in the sampler into the blood separation valve through the front pipeline connecting the sampler and the blood separation valve, Thus, the blood sample is divided into a first part of blood sample and a second part of blood sample and allocated to the erythrocyte sedimentation rate detection module and the blood routine detection module respectively;

Red blood cell sedimentation rate detection step: The erythrocyte sedimentation rate detection module irradiates the first part of the blood sample with light, and detects the degree of absorption or scattering of the light by the first part of the blood sample to obtain the red blood cell sedimentation rate of the first part of the blood sample ；

Routine blood detection step: The routine blood detection device detects the blood routine parameters of the second part of the blood sample.

In one embodiment, the time for the erythrocyte sedimentation rate detection module to detect the erythrocyte sedimentation rate of the first part of the blood sample overlaps with the time for the blood routine detection module to detect the blood routine parameter of the second part of the blood sample.

In an embodiment, the sample allocation step includes:

The blood separation valve distributes the first part of the blood sample to the detection pipeline of the erythrocyte sedimentation rate detection module or the erythrocyte sedimentation detection pool connected to the detection pipeline through its first sample transmission channel;

At the same time, the blood separation valve distributes the second part of blood samples to the blood routine detection pool of the blood routine detection module through its second sample transmission channel.

In an embodiment, the sample allocation step includes:

The first power device draws the blood sample in the sampler into the blood separation valve through the front pipeline until a part of the blood sample flows to connect the first power device and the blood separation valve In the connected back pipeline, the blood sample in the back pipeline is the first part of blood sample;

Then, the blood separation valve distributes the second part of the blood sample to the blood routine detection pool of the blood routine detection module through its sample transmission channel.

In one embodiment, the time when the erythrocyte sedimentation rate detection module starts to detect the erythrocyte sedimentation rate of the first part of blood sample is the same or different from the time when the blood routine detection module starts to detect the blood routine parameter of the second part of blood sample. the same.

In one embodiment, the blood routine detection module is first activated to perform blood routine parameter detection on the second part of blood samples, and then the erythrocyte sedimentation rate detection module is activated to detect the red blood cell sedimentation rate of the first part of blood samples.

In one embodiment, the sample analysis method is applied to the sample analyzer described in any of the above embodiments.

The beneficial effects of this application:

The sample analyzer provided by the embodiment of the present application includes a blood separation valve, which is connected to the sampler through a front pipeline and is connected to the first power device through a rear pipeline. The blood separation valve is also connected to the detection pipeline and the blood routine detection pool respectively, so that after the sampler collects the blood sample, the blood separation valve can distribute the blood sample into the first part of the blood sample and the second part of the blood sample, and realize Allocate the first part of the blood sample to the testing pipeline and the second part of the blood sample to the routine blood test pool, so that the ESR module and the routine blood test module can independently and parallel test the blood cell sedimentation rate and routine blood test parameters, without waiting The detection of the next detection module can only be performed after the detection of the previous detection module is completed. The overall detection time is short and the detection efficiency is high.

Description of the drawings

The advantages of the above and/or additional aspects of the present application will become obvious and easy to understand from the description of the embodiments in conjunction with the following drawings, in which:

FIG. 1 is a schematic diagram of the structure of a sample analyzer provided by an embodiment of the application;

FIG. 2 is a schematic structural diagram of the blood separation valve shown in FIG. 1 in another working state;

Fig. 3 is a schematic diagram of the connection between the blood separation valve shown in Fig. 2 and the sampler and the first power device in this working state;

FIG. 4 is a working sequence diagram of a sample analyzer provided by an embodiment of the application;

FIG. 5 is a schematic structural diagram of a sample analyzer provided by an embodiment of the application;

FIG. 6 is a working sequence diagram of a sample analyzer provided by an embodiment of the application;

FIG. 7 is a schematic structural diagram of a sample analyzer provided by an embodiment of the application;

FIG. 8 is a schematic structural diagram of a sample analyzer provided by an embodiment of the application;

FIG. 9 is a schematic flowchart of a sample analysis method provided by an embodiment of the application.

The correspondence between the reference signs and component names in Figures 1 to 8 is:

10. Sampling distribution module; 11. Sampler; 111, Sampling needle; 12. Blood separation valve; 121, Liquid inlet; 122, Liquid outlet; 123, Outer sheet; 1231, Liquid inlet; 1232, Liquid outlet 1233, the first outer liquid distribution channel; 1234, the second outer liquid distribution channel; 124, the middle piece; 1241, the first middle liquid distribution channel; 1242, the second middle liquid distribution channel; 125, the inner piece; 1251, the connection Channels; 1252, the first internal liquid distribution channel; 1253, the second internal liquid distribution channel; 13, the first power unit; 14, the front pipeline; 15, the rear pipeline; 20, the erythrocyte sedimentation rate detection module; 21, the detection pipeline 22. Optical detection device; 221, optical transmitter; 222, optical receiver; 23, blood sedimentation detection pool; 24, second power device; 30, blood routine detection module; 31, blood routine detection pool; 40, liquid circuit Support module; 50. Control module.

Detailed ways

In order to make the purpose, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be described clearly and completely in conjunction with the accompanying drawings in the embodiments of the present application. Obviously, the described embodiments These are a part of the embodiments of the present application, but not all of the embodiments. Based on the embodiments in this application, all other embodiments obtained by a person of ordinary skill in the art without creative work shall fall within the protection scope of this application.

Figure 1 is a schematic structural diagram of a sample analyzer provided by an embodiment of the application, Figure 2 is a structural schematic diagram of the blood separation valve shown in Figure 1 in another working state, and Figure 3 is a schematic diagram of the blood separation valve shown in Figure 2 Schematic diagram of the connection with the sampler and the first power device in this working state.

As shown in FIGS. 1 to 3, an embodiment of the present application provides a sample analyzer, which includes a sampling distribution module 10, an erythrocyte sedimentation rate detection module 20, and a blood routine detection module 30.

The sampling distribution module 10 includes a sampler 11, a blood separation valve 12 and a first power device 13. The sampler 11 is used to collect blood samples, and the blood separation valve 12 is connected to the sampler 11 through the front pipeline 14 and is connected to the first power device 13 through the rear pipeline 15. The first power device 13 is used to drive the sampler 11 to collect blood samples and draw the collected blood samples into the blood separation valve 12 through the front pipeline 14. The blood separation valve 12 is used to divide the blood sample into a first part of blood sample and a second part of blood sample.

The erythrocyte sedimentation rate detection module 20 includes a detection pipeline 21 and an optical detection device 22. The detection line 21 is connected to the blood separation valve 12 and is used to provide a testing place for the first part of the blood sample distributed by the blood separation valve 12. The optical detection device 22 is arranged corresponding to the detection tube 21, and is used to irradiate the first part of the blood sample in the detection tube 21 with light and detect the degree of absorption or scattering of light by the first part of the blood sample in the detection tube 21 to obtain The first part of the erythrocyte sedimentation rate of the blood sample. When the erythrocyte sedimentation rate is detected by the erythrocyte sedimentation rate detection module 20, the first part of the blood sample does not move in the detection tube 21, that is, remains stationary.

The blood routine detection module 30 includes a blood routine detection pool 31 and a blood routine detection device (not shown). The blood routine detection pool 31 is connected to the blood separation valve 12 and is used to provide a testing place for the second part of the blood sample distributed by the blood separation valve 12, and the blood routine detection device performs blood routine testing on the second part of the blood sample in the blood routine detection pool 31 Detection.

Specifically, the first power device 13 is used to provide negative pressure to draw blood samples from the sampler 11 to the blood separation valve 12. The first power device 13 may be a pump, a syringe or other pressure source capable of providing power, such as a positive and negative air pressure source.

In this embodiment, the blood separation valve 12 has two different working states. In the first working state, as shown in FIGS. 2 and 3, after the blood sample is collected by the sampler 11, the first power device 13 draws the blood sample from the sampler 11 through the front line 14 and the back line 15 In the blood separation valve 12, the blood separation valve 12 divides the blood sample into a first part of blood sample and a second part of blood sample.

As shown in Figure 1, the blood separation valve 12 is switched to the second working state, and the blood separation valve 12 is respectively connected with the detection line 21 of the erythrocyte sedimentation rate detection module 20 and the blood routine detection pool 31 of the blood routine detection module 30. The first part The blood sample enters the erythrocyte sedimentation rate detection pipeline 21 for the detection of the red blood cell sedimentation rate, and the second part of the blood sample enters the blood routine detection pool 31 for the routine blood parameter detection.

The connection between the routine blood detection pool 31 and the blood separation valve 12 mentioned here may refer to the connection by setting a pipeline between the blood separation valve 12 and the routine blood detection pool 31. It can also mean that there is only a liquid connection between the blood routine detection pool 31 and the blood separation valve 12, as long as the second part of the blood sample in the blood separation valve 12 can be allocated to the routine blood detection pool 31. Specific implementations There is no specific limitation here.

The blood routine detection device may be an optical detection device or an impedance detection device. When the routine blood testing module 30 performs routine blood testing on a blood sample, the blood sample and corresponding reaction reagents can be added to the routine blood testing pool 31, and the blood routine testing device measures the blood sample in the routine blood testing pool 31 To obtain at least one blood routine parameter, the blood routine parameter may include five classification results of WBC (White blood cell, white blood cell), WBC count and morphological parameters, HGB (Hemoglobin, hemoglobin) function measurement, RBC (Red blood cell, red blood cell) ) And at least one or more combinations of PLT (blood platelet) count and morphological parameters. In the actual blood routine testing process, blood routine testing items can be added or reduced as needed, which is not limited here.

The working process of the sample analyzer provided in an embodiment of the present application is as follows:

The first power device 13 drives the sampler 11 to collect blood samples and draws the blood samples collected by the sampler 11 into the blood separation valve 12 through the front pipeline 14. The blood separation valve 12 divides the blood sample into the first part blood sample and the second part. Two parts of blood samples.

The first part of the blood sample is allocated to the detection tube 21, and the optical detection device 22 irradiates the first part of the blood sample in the detection tube 21 with light and detects the degree of absorption or scattering of the light by the first part of the blood sample, thereby detecting the first part of blood The red blood cell sedimentation rate of the sample.

The second part of the blood sample is allocated to the routine blood test pool 31, and the routine blood test device performs routine blood test on the second part of the blood sample in the routine blood test pool 31.

The sample analyzer provided in the embodiment of the present application includes a blood separation valve 12, which is connected to the sampler 11 through a front pipeline 14 and is connected to the first power device 13 through a rear pipeline 15. The blood separation valve 12 is also connected to the detection line 21 and the blood routine detection pool 31 respectively, so that after the sampler 11 collects the blood sample, the blood separation valve 12 can divide the blood sample into the first part of the blood sample and the second part. Blood samples, and allocate the first part of blood samples to the detection line 21 and the second part of blood samples to the routine blood test pool 31, so that the blood sedimentation detection module 20 and the routine blood detection module 30 can independently and concurrently detect blood cell sedimentation The detection rate and blood routine detection parameters do not need to wait for the detection of the previous detection module to complete the detection of the next detection module. The overall detection time is short and the detection efficiency is high.

In the sample analyzer provided by the embodiment of the present application, the erythrocyte sedimentation rate detection module 20 and the routine blood sedimentation detection module 30 can be activated for detection at the same time, or the erythrocyte sedimentation rate detection module 20 and the routine blood sedimentation detection module 30 can be activated in order for detection, as long as the erythrocyte sedimentation rate detection module There is an overlap in the detection time between 20 and the blood routine detection module 30, which can realize parallel detection and shorten the overall time of the two items of detection, which is not specifically limited here.

Unlike in the prior art, the erythrocyte sedimentation rate detection module 20 and the blood routine detection module 30 are connected in series to perform corresponding erythrocyte sedimentation rate detection and blood routine detection. The sample analyzer provided in the embodiment of the present application includes an erythrocyte sedimentation rate detection that can be independently detected. The module 20 and the blood routine detection module 30 do not need to wait for the detection of the previous detection module to complete the detection of the next detection module, so that the erythrocyte sedimentation rate detection module 20 can detect the red blood cell sedimentation rate of the first part of the blood sample and the blood routine detection module 30. The time for detecting the blood routine parameters of the second part of the blood sample overlaps, so that the erythrocyte sedimentation rate detection module 20 and the blood routine detection module 30 can perform parallel detection in time, so as to shorten the total time of testing two items, thereby increasing Detection efficiency.

As shown in FIG. 3, the sampler 11 provided by the embodiment of the present application includes a sampling needle 111 and a driving device (not shown in the figure). The driving device is used to drive the sampling needle 111 to move to the position where the test tube storing the blood sample is located. Collect blood samples in test tubes. Specifically, the driving device only needs to be a mechanical structure that can drive the sampling needle 111 to move, which is not specifically limited here.

As shown in FIG. 3, the blood sample is usually stored in a test tube 100, and the top of the test tube 100 is provided with a cap for sealing. The driving device drives the sampling needle 111 to move to the corresponding test tube 100. The end of the sampling needle 111 with the tip of the needle pierces the cap of the test tube 100, and then extends into the test tube 100 to suck the blood sample in the test tube 100 to collect the blood sample.

Specifically, the first power device 13 also provides negative pressure to the sampling needle 111 so that the sampling needle 111 can suck blood samples from the test tube 100.

In an embodiment of the present application, the blood separation valve 12 includes a liquid inlet 121, a first liquid separation port, a second liquid separation port, and a liquid outlet 122.

As shown in FIG. 3, the liquid inlet 121 is connected to the sampler 11 through the front pipeline 14, and the first power device 13 drives the blood sample collected by the sampler 11 to flow into the blood separation valve 12 through the liquid inlet 121.

As shown in FIG. 1, the first liquid separation port is connected to the detection pipeline 21, and the first liquid separation port is used for the first part of the blood sample distributed by the blood separation valve 12 to flow into the detection pipeline 21. In other words, the blood separation valve 12 distributes the first part of the blood sample into the detection tube 21 through the first sample transmission channel. The second liquid separation port is connected to the routine blood detection pool 31, and the second liquid separation port is used for the second part of the blood sample distributed by the blood separation valve 12 to flow into the routine blood detection pool 31. In other words, the blood separation valve 12 distributes the second part of the blood sample into the blood routine detection pool 31 through the second sample transmission channel.

As shown in FIG. 3, the liquid outlet 122 is connected to the first power device 13 through the rear pipeline 15, and the first power device 13 drives the blood sample in the blood separation valve 12 to flow from the liquid outlet 122 to the rear pipeline 15. . For example, after the detection is completed, the first power device 13 may drive the remaining blood sample in the blood separation valve from the liquid outlet 122 to the rear pipeline 15 for further discharge.

In an embodiment of the present application, as shown in FIG. 1 and FIG. 2, the blood separation valve 12 includes an outer sheet 123, a middle sheet 124 and an inner sheet 125 coaxially attached in sequence.

The outer sheet 123 is provided with a liquid inlet channel 1231, a liquid outlet channel 1232, a first outer liquid dividing channel 1233, and a second outer liquid dividing channel 1234. One port of the liquid inlet channel 1231 is the liquid inlet 121 and the liquid outlet channel 1232. One port is the liquid outlet 122.

The middle plate 124 is provided with a first middle liquid distribution channel 1241 and a second middle liquid distribution channel 1242.

The inner sheet 125 is provided with a connecting channel 1251, a first inner liquid distribution channel 1252, and a second inner liquid distribution channel 1253. A port of the first inner liquid distribution channel 1252 away from the first middle liquid distribution channel 1241 is the first liquid distribution port A port of the second inner liquid distribution channel 1253 away from the second middle liquid distribution channel 1242 is the second liquid distribution port.

The middle piece 124 can move relative to the outer piece 123 and the inner piece 125, thereby changing the relative position between the middle piece 124 and the outer piece 123 and the inner piece 125, thereby changing the working state of the blood separation valve 12.

In an embodiment of the present application, the outer piece 123 and the inner piece 125 are fixed, and the middle piece 124 can rotate coaxially with respect to the outer piece 123 and the inner piece 125.

Referring to the working sequence diagram of the sample analyzer shown in FIG. 4, in an embodiment of the present application, the working process of the sample analyzer is as follows:

Rotate the middle plate 124 so that the blood separation valve 12 is in the first working state, namely: the liquid inlet channel 1231, the first middle liquid distribution channel 1241, the connecting channel 1251, the second middle liquid distribution channel 1242 and the liquid outlet channel 1232 are connected in sequence through. The first power device 13 provides power (for example, negative pressure), so that the blood sample in the sampling needle 111 sequentially passes through the front pipeline 14, the liquid inlet channel 1231, the first middle liquid distribution channel 1241, and the second middle liquid distribution channel 1242. The channel 1251, the liquid outlet channel 1232, and the rear pipeline 15 are such that the blood sample collected by the sampling needle 111 flows in the blood separation valve 12 and fills the liquid inlet channel 1231, the first middle liquid distribution channel 1241, and the second middle divider. The liquid channel 1242 is connected to the channel 1251 and the liquid outlet channel 1232, so that the blood sample can be divided into the first part of the blood sample and the second part of the blood sample. In the embodiment shown in FIGS. 1 and 2, the blood sample in the first middle distribution channel 1241 is the first part of blood sample, and the blood sample in the second middle distribution channel 1242 is the second part of blood sample.

Then rotate the middle plate 124 so that the blood separation valve 12 is in the second working state, that is, the first middle liquid separation channel 1241 is respectively communicated with the first outer liquid distribution channel 1233 and the first inner liquid distribution channel 1252 to form a second The same transfer channel; and the second middle liquid distribution channel 1242 respectively communicate with the second outer liquid distribution channel 1234 and the second inner liquid distribution channel 1253 to form a second sample transmission channel, so that the first middle liquid distribution channel 1241 The first part of blood sample in the inside and the second part of blood sample in the second middle liquid distribution channel 1242 can be distributed into the detection tube 21 and the blood routine detection pool 31 at the same time.

In an embodiment, the first outer liquid distribution channel 1233 is connected to a power source (not shown) through a pipeline, so that the first part of blood sample in the first middle liquid distribution channel 1241 can be driven through the first inner liquid distribution channel. 1252, and then enter the detection pipeline 21. In another embodiment, the first part of the blood sample in the first middle liquid distribution channel 1241 can also be sucked through the first inner liquid distribution channel 1252 by a power source connected to the detection tube 21, and then sucked into the detection tube. Within road 21.

In one embodiment, the second outer liquid distribution channel 1234 is connected to a power source (not shown) through a pipe, so that the second part of blood sample in the second middle liquid distribution channel 1242 can be driven through the second inner liquid distribution channel 1242. The channel 1253 then enters the blood routine detection pool 31. The power source connected to the second external liquid distribution channel 1234 includes a pump or a syringe and a diluent source. The pump or syringe extracts the diluent, and then pushes the extracted diluent to the second external liquid distribution channel 1234, and then the second external liquid distribution channel 1234 is transferred through the diluent. The second part of the blood sample in the second liquid separation channel 1242 is pushed into the blood routine detection pool 31.

Those skilled in the art can understand that although FIG. 1 only shows a second sample transmission channel formed by the communication of the second outer liquid distribution channel 1234, the second middle liquid distribution channel 1242, and the second inner liquid distribution channel 1253, this The application embodiment is not limited to this. The blood routine detection device can be used to detect many of reticulocytes, nucleated red blood cell analysis, white blood cells, hemoglobin analysis and red blood cells. Correspondingly, the blood separation valve 12 includes a plurality of sample transmission channels among a channel for reticulocyte measurement, a channel for nucleated red blood cell analysis, a channel for white blood cell analysis, a channel for hemoglobin analysis, and a channel for red blood cell measurement. After the blood samples are quantitatively separated by the blood separation valve 12, they are respectively distributed through the corresponding channels.

The sample analyzer provided in the embodiment of the present application connects the first liquid separation port of the blood separation valve 12 with the detection pipeline 21 and connects the second liquid separation opening to the blood routine detection pool 31, so that the second liquid distribution can be realized at the same time. Part of the blood sample and the second part of the blood sample, so that the erythrocyte sedimentation rate detection module 20 and the blood routine detection module 30 can independently and concurrently detect the blood cell sedimentation rate and blood routine detection parameters, without waiting for the detection of the previous detection module to complete the next detection Module detection, the overall detection time is short, and the detection efficiency is high.

In the embodiment of the present application, after the first part of blood sample and the second part of blood sample are distributed at the same time, the erythrocyte sedimentation rate detection module 20 and the blood routine detection module 30 can start to detect the red blood cell sedimentation rate and blood routine parameters at the same time, and there is no waiting time, thereby The overall detection time is short, which further improves the detection efficiency.

The erythrocyte sedimentation rate detection module 20 and the blood routine detection module 30 can start the detection at the same time, or they can start the detection sequentially. For example, the blood routine detection module 30 first starts the blood routine parameter detection, and the erythrocyte sedimentation rate detection module 20 starts the red blood cell sedimentation rate detection. Make a limit.

In addition, the erythrocyte sedimentation rate detection module 20 and the routine blood detection module 30 need to be cleaned after the detection is completed to perform the next detection, so as to prevent the residue of the previous blood sample from affecting the detection result of the next blood sample. The sampling distribution module 10 also needs to be cleaned to collect the next blood sample to be tested.

FIG. 5 is a schematic structural diagram of a sample analyzer provided by an embodiment of the application. As shown in FIG. 5, the erythrocyte sedimentation rate detection module 20 also includes an erythrocyte sedimentation rate detection pool 23 independent of the routine blood sedimentation pool 31. The detection pipeline 21 is connected to the blood separation valve 12 through the erythrocyte sedimentation rate detection pool 23. The first part of the blood sample dispensed by the blood valve 12.

The detection pipeline 21 provided by the embodiment of the present application is connected to the blood separation valve 12 through the ESR detection pool 23, which may refer to the connection between the ESR detection pool 23 and the blood separation valve 12 through a pipeline. A part of the blood sample is injected into the ESR detection pool 23 through the pipeline.

As shown in FIGS. 1 and 5, in an embodiment of the present application, the erythrocyte sedimentation rate detection module 20 further includes a second power device 24 connected to the detection pipeline 21, and the second power device 24 is used to drive the blood separation valve 12 The distributed first part of blood sample flows into the detection tube 21, and after the first part of blood sample flows to the detection area in the detection tube 21, it stops moving and remains motionless, so that the optical detection device 22 can detect the red blood cells of the first part of the blood sample. The sedimentation rate is tested. In other words, the second power device 24 is not only used to drive the first part of the blood sample into the detection tube 21, but also to ensure that the first part of the blood sample in the detection tube 21 remains stationary when the red blood cell sedimentation rate is detected. .

Specifically, the working process of detecting ESR provided by the embodiment of the present application is as follows:

The second power device 24 drives the blood sample to flow into the detection tube 21. When the blood sample flows to a specific position (detection area) of the detection tube 21, the second power device 24 instantaneously interrupts the flow of the blood sample in the detection tube 21 , Resulting in a sudden deceleration (or stop of flow) of the blood sample at this time, and subsequent aggregation and precipitation of red blood cells. During the process of aggregation and precipitation of red blood cells, the signal detected by the optical detection device 22 will change, thereby obtaining information for determining ESR.

Compared with the Widmanstatten method in the prior art, the sample analyzer provided in the embodiment of the present application can limit the length of the detection pipeline 21, which can not only reduce the volume of the entire instrument, but also reduce the amount of blood required for detection and analysis, and the amount of blood required for detection and analysis can be reduced. The amount of cleaning liquid in the pipeline 21.

In the embodiment shown in FIG. 1, one end of the detection pipeline 21 is directly connected to the blood separation valve 12, and the other end is connected to the second power device 24. The second power device 24 collects the first part of the blood sample in the blood separation valve 12 Drive into the detection pipeline 21.

In the embodiment shown in FIG. 5, one end of the detection pipeline 21 is indirectly connected to the blood separation valve 12 through the ESR detection tank 23, and the other end of the detection pipeline 21 is connected to the second power device 24. The device 24 drives the first part of the blood sample in the ESR detection pool 23 distributed by the blood separation valve 12 to the detection pipeline 21.

After detecting the red blood cell sedimentation rate, the second power device 24 can also drive the first part of the blood sample in the detection tube 21 to flow to discharge the detection tube 21 to prepare for the next detection.

The second power device 24 may be a pump, a syringe or other pressure source that can provide power.

FIG. 6 is a schematic diagram of the structure of a sample analyzer provided by an embodiment of the application. As shown in FIG. 6, the detection pipeline 21 provided by the embodiment of the present application is directly arranged in the rear pipeline 15, that is, a part of the rear pipeline 15 is the detection pipeline 21. In an embodiment, the part of the rear pipeline 15 close to the blood separation valve 12 is set as the detection pipeline 21. At this time, the first power device 13 draws the blood sample collected by the sampler 11 into the blood separation valve 12 until a part of the blood sample flows into the detection tube 21 of the rear tube 15 and is in the detection tube of the rear tube 15 The blood sample in the road 21 is the first part of the blood sample. The blood separation valve 12 still distributes the second part of the blood sample to the blood routine detection pool 31 through its sample transmission channel, as described above.

That is, the detection pipeline 21 is directly coupled with the liquid outlet 122 of the blood separation valve 12, so that when the blood separation valve 12 is in the first working state, the first power device 13 drives the blood samples in the sampling needle 111 to pass through the inlet in turn. The liquid channel 1231, the first middle liquid distribution channel 1241, the connecting channel 1251, the second middle liquid distribution channel 1242, and the liquid outlet channel 1232 flow into the rear pipeline 15, that is, the detection pipeline 21, and the part in the rear pipeline 15 The blood sample is the first part of the blood sample. At this time, the first power device 13 can function as the above-mentioned second power device 24, so it is not necessary to additionally provide the second power device 24 in this embodiment.

The first internal liquid separation channel 1252 or the second internal liquid separation channel 1253 of the blood separation valve 12 in the sample analyzer provided by the embodiment of the present application is connected to the blood routine detection pool 31. When the blood separation valve 12 is in the first working state, the first middle liquid separation channel 1241 or the second middle liquid separation channel 1242 is filled with blood samples. When the blood separation valve 12 is switched to the second working state, the blood sample in the first middle dispensing channel 1241 or the second middle dispensing channel 1242 can pass through the correspondingly connected first inner dispensing channel 1252 or second inner dispensing channel 1252 or The liquid channel 1253 flows into the blood routine detection pool 31 to detect blood routine parameters.

Referring to the working sequence diagram of the sample analyzer shown in FIG. 7, the working process of the sample analyzer provided in an embodiment of the present application is as follows:

Rotate the middle plate 124 to make the blood separation valve 12 in the first working state, namely: the liquid inlet channel 1231, the first middle liquid distribution channel 1241, the connecting channel 1251, the second middle liquid distribution channel 1242 and the liquid outlet channel 1232 are connected in sequence . The first power device 13 provides power (for example, negative pressure), so that the blood sample in the sampling needle 111 sequentially passes through the front pipeline 14, the liquid inlet channel 1231, the first middle liquid distribution channel 1241, and the second middle liquid distribution channel 1242. The channel 1251 and the liquid outlet channel 1232 enter the rear pipeline 15 so that the blood sample at least fills the liquid inlet channel 1231, the first middle liquid distribution channel 1241, the second middle liquid distribution channel 1242, the connection channel 1251 and the liquid outlet channel 1232. At this time, there are also some blood samples in the rear tube 15. By setting the detection tube 21 of the erythrocyte sedimentation detection module 20 in the rear tube 15, the optical detection device 22 of the erythrocyte sedimentation detection module 20 is installed in the rear tube. At the road 15, the blood sample existing in the back pipe 15 can be directly used as the first part of the blood sample to detect the red blood cell sedimentation rate.

Then the middle plate 124 is rotated to switch the blood separation valve 12 to the second working state, that is, the first middle liquid distribution channel 1241 is respectively communicated with the first outer liquid distribution channel 1233 and the first inner liquid distribution channel 1252 to form a second operation state. The same transfer channel; and the second middle liquid distribution channel 1242 respectively communicate with the second outer liquid distribution channel 1234 and the second inner liquid distribution channel 1253 to form a second sample transmission channel, so that the first middle liquid distribution channel 1241 Or, the blood sample in the second middle liquid distribution channel 1242 can flow into the blood routine detection pool 31.

Then, the erythrocyte sedimentation rate detection module 20 and the blood routine detection module 30 can be activated simultaneously or successively to perform detection.

In other words, the erythrocyte sedimentation rate detection module 20 and the rear pipeline 15 of the blood separation valve 12 are directly coupled in structure. After the sampling and distribution module 10 completes aspiration, the erythrocyte sedimentation rate detection module 20 can be activated to detect the red blood cell sedimentation rate, as shown in FIG. 7. It is also possible to first divide blood to the blood routine detection module through the blood separation valve 12, and then start the erythrocyte sedimentation rate detection and blood routine detection at the same time or at different times. At this time, the pipeline of the sampling distribution module 10 can be cleaned after the erythrocyte sedimentation rate detection module 20 completes the detection.

The sample analyzer provided in the embodiment of the present application directly sets the detection line 21 in the back line 15, that is, reuses the back line 15 as the detection line 21, which can not only make full use of the blood in the back line 15 Sample, and the second power device 24 can be omitted, the structure is simple, and the cost is saved.

As shown in FIGS. 1, 5 and 6, in the embodiment of the present application, the optical detection device 22 includes a light transmitter 221 and a light receiver 222. The light transmitter 221 and the light receiver 222 are located on both sides of the detection area of the detection pipeline 21, respectively. The light emitter 221 is used to illuminate the first part of the blood sample in the detection area. The light receiver 222 is used to detect the change of the light emitted by the light emitter 221 after irradiating the first part of the blood sample (for example, receiving the light transmitted and/or scattered by the first part of the blood sample), and by detecting the amount of light received How much to detect the degree of absorption or scattering of light by the first part of the blood sample.

When the erythrocyte sedimentation rate detection module 20 is activated for detection, the second power device 24 drives the first part of the blood sample to flow into the detection tube 21, and stops the movement after the first part of the blood sample flows to the detection area, and then causes the first part of the blood sample to be detected Keep it still in the area. The light emitter 221 irradiates the first part of the blood sample in the detection area with light, and the light receiver 222 detects the degree of scattering or transmission of the light emitted by the light emitter 221 after irradiating the first part of the blood sample in the detection area, that is, by detecting light The amount of light received by the receiver 222 is used to detect the red blood cell sedimentation rate.

As the red blood cells in the blood sample gather (form a money-like shape), the scattering or transmission of the light irradiated on the blood sample will change. Therefore, the amount of light transmitted or scattered after the blood sample is irradiated can be measured. To detect the degree of light scattering or absorption of the first part of the blood sample, so as to measure the red blood cell sedimentation rate.

The number of the optical receiver 222 is one or more, which is not limited here.

In an embodiment of the present application, the detection pipeline 21 is made of a hose, and the detection area of the detection pipeline 21 is made of a light-transmitting material. Therefore, the detection pipeline 21 can be arbitrarily and flexibly arranged, for example, it can be arranged vertically, horizontally or obliquely, or arranged in a curved manner, which is not limited.

In an embodiment of the present application, the detection pipeline 21 is configured as a capillary tube.

Since the erythrocyte sedimentation rate detection module 20 provided in the sample analyzer provided in this embodiment detects the red blood cell sedimentation rate by detecting the degree of light scattering or absorption of the red blood cells in the blood sample during the aggregation process (that is, the ESR is realized by detecting the red blood cell aggregation speed). Detection), compared to the detection method of waiting for the red blood cells to settle naturally under the action of gravity (Widman's method), the detection speed is faster, the red blood cell sedimentation rate detection can be completed in a short time (for example, 20s), and the blood consumption is less. Only about 100uL. In addition, for the Widmanstatten method, a hard detection tube must be installed in a straight line and installed vertically or slightly inclined, which tends to make the instrument too large. However, the installation angle of the detection pipeline 21 provided by the embodiment of the present application is not limited, and can be flexibly adjusted according to the settings of other structures inside the sample analyzer, so that the overall volume of the sample analyzer can be reduced, and the sample analyzer occupies a small space. .

FIG. 8 is a schematic structural diagram of a sample analyzer provided by an embodiment of the application. As shown in FIG. 8, the sample analyzer provided by the embodiment of the present application further includes a liquid path support module 40, which is used to allocate the module 10, the erythrocyte sedimentation rate detection module 20, and the blood routine detection module 30 for the sample (not corresponding to the identification in FIG. 8) Provide hydraulic support. Specifically, the liquid path support module 40 performs liquid path support by providing liquid to the sampling distribution module 10, the erythrocyte sedimentation rate detection module 20, and the blood routine detection module 30. For example, the liquid path support module 40 may provide cleaning solutions to the sampling distribution module 10, the erythrocyte sedimentation rate detection module 20, and the blood routine detection module 30, respectively, to clean the sampling needle 111, the detection line 21, and the blood routine detection pool 31, respectively. Contaminate the blood sample to be tested, resulting in inaccurate test results.

In an embodiment, the reagent loading, reaction mixing, measurement action, cleaning and maintenance of the ESR detection module and the routine blood detection module are all assisted by the liquid path support module.

As shown in FIG. 8, the sample analyzer further includes a control module 50, which is connected to the sampling distribution module 10, the erythrocyte sedimentation rate detection module 20, the blood routine detection module 30, and the liquid path support module 40, respectively. Control the actions of the sampling distribution module 10, the erythrocyte sedimentation rate detection module 20, the blood routine detection module 30, and the liquid path support module 40 so that the sampling distribution module 10, the erythrocyte sedimentation rate detection module 20, the blood routine detection module 30 and the liquid path support module 40 Cooperate with each other to complete the detection of erythrocyte sedimentation rate and blood routine parameters.

The embodiment of the present application also provides a sample analysis method. As shown in FIG. 9, the method includes the following steps:

Sampling distribution step S200: the first power device 13 drives the sampler 11 to collect blood samples and draws the blood samples in the sampler 11 into the blood separation valve 12 through the front pipeline 14 connecting the sampler 11 and the blood separation valve 12, In order to divide the blood sample into a first part of blood sample and a second part of blood sample and distribute them to the erythrocyte sedimentation rate detection module 20 and the blood routine detection module 30 respectively;

Red blood cell sedimentation rate detection step S210: The erythrocyte sedimentation rate detection module 20 irradiates the first part of the blood sample with light, and detects the degree of absorption or scattering of the light by the first part of the blood sample to obtain the red blood cell sedimentation rate of the first part of the blood sample;

Routine blood detection step S230: The routine blood detection device 30 detects the blood routine parameters of the second part of the blood sample.

In the sample analysis method provided by the embodiment of the present application, after the sampler 11 collects the blood sample and transports the blood sample to the blood separation valve 12, the blood separation valve 12 divides the blood sample into a first part of blood sample and a second part of blood sample, and then separately The first part of the blood sample flows into the erythrocyte sedimentation rate detection module 20 and the second part of the blood sample flows into the blood routine detection module 30, so that different parts of the same blood sample are allocated to the erythrocyte sedimentation rate detection module 20 and the blood routine detection module 30, thereby making the erythrocyte sedimentation rate The detection module 20 and the blood routine detection module 30 can be independently tested in parallel, and the detection of the next detection module does not need to be waited until the detection of the previous detection module is completed. The overall detection time is short, thereby improving detection efficiency.

In the sample analysis method provided by the embodiment of the present application, the time for the erythrocyte sedimentation rate detection module 20 to detect the erythrocyte sedimentation rate of the first part of blood sample and the time for the blood routine detection module 30 to detect the blood routine parameter of the second part of blood sample overlap, that is, the step There is a time overlap between 210 and step 220, so that the erythrocyte sedimentation rate detection module 20 and the blood routine detection module 30 can perform parallel detection in time, so as to shorten the total time for detecting two items.

In the sample analysis method provided by the embodiment of the present application, the time when the erythrocyte sedimentation rate detection module 20 starts to detect the erythrocyte sedimentation rate of the first part of the blood sample is the same or different from the time when the blood routine detection module 30 starts to detect the blood routine parameter of the second part of the blood sample , There is no specific limitation here.

Optionally, the blood routine detection module 30 is first activated to perform blood routine parameter detection on the second part of blood samples, and then the erythrocyte sedimentation rate detection module 20 is activated to detect the erythrocyte sedimentation rate of the first part of blood samples. Since the ESR detection method used in this application has a faster speed than routine blood detection, starting blood routine detection first is beneficial to issuing a total test report as soon as possible.

In other embodiments, the erythrocyte sedimentation rate detection module 20 may be activated to detect the erythrocyte sedimentation rate of the first part of the blood sample, and then the blood routine detection module 30 may be activated to detect the blood routine parameter of the second part of the blood sample; or the erythrocyte sedimentation rate detection module may be activated at the same time 20 and the blood routine detection module 30 perform detection, which is not limited here.

In an embodiment of the present application, the sampling allocation step S200 includes:

The blood separation valve 12 distributes the first part of the blood sample to the detection pipeline 21 of the erythrocyte sedimentation rate detection module 20 or the erythrocyte sedimentation detection pool 23 connected to the detection pipeline 21 through its first sample transmission channel;

At the same time, the blood separation valve 12 distributes the second part of the blood sample to the blood routine detection pool 31 of the blood routine detection module 30 through its second sample transmission channel.

In an embodiment of the present application, the sampling allocation step S200 includes:

The first power device 13 draws the blood sample in the sampler 11 into the blood separation valve 12 through the front pipeline 14 until a part of the blood sample flows to the rear pipeline 15 connecting the first power device 13 and the blood separation valve 12 , The blood sample in the back pipe 14 is the first part of blood sample;

Then, the blood separation valve 12 distributes the second part of the blood sample to the blood routine detection pool 31 of the blood routine detection module 30 through its sample transmission channel.

The sample analysis method provided in the embodiments of the present application is applied to the above-mentioned sample analyzer. For more embodiments of the sample analysis method, please refer to the description of the above-mentioned sample analyzer, which will not be repeated here.

It should be noted that in this article, relational terms such as "first" and "second" are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply these There is any such actual relationship or sequence between entities or operations. Moreover, the terms "include", "include" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements not only includes those elements, but also includes those that are not explicitly listed Other elements of, or also include elements inherent to this process, method, article or equipment. Without more restrictions, the element defined by the sentence "including a..." does not exclude the existence of other identical elements in the process, method, article, or equipment that includes the element.

The above features mentioned in the specification, drawings and claims can be combined with each other arbitrarily as long as they are meaningful in this application. The features and advantages described for the sample analysis system according to the present application are applicable to the sample analysis method according to the present application in a corresponding manner, and vice versa.

The above are only specific implementations of the application, so that those skilled in the art can understand or implement the application. Various modifications to these embodiments will be obvious to those skilled in the art, and the general principles defined herein can be implemented in other embodiments without departing from the spirit or scope of the application. Therefore, this application will not be limited to the embodiments shown in this document, but should conform to the widest scope consistent with the principles and novel features applied in this document.

Claims (16)

1. A sample analyzer, characterized in that it comprises:

   The sampling distribution module includes a sampler, a blood separation valve, and a first power device. The sampler is used to collect blood samples. The blood separation valve is connected to the sampler through a front pipeline and is connected to the first power device through a rear pipeline. A power device is connected. The first power device is used to drive the sampler to collect blood samples and draw the collected blood samples into the blood separation valve through the front pipeline, wherein the blood separation valve is used To divide the blood sample into a first part of blood sample and a second part of blood sample;

   The erythrocyte sedimentation rate detection module includes a detection pipeline and an optical detection device, the detection pipeline is connected to the blood separation valve and is used to provide a detection place for the first part of the blood sample distributed by the blood separation valve, the optical detection device Used to irradiate the first part of the blood sample in the detection tube with light and detect the degree of absorption or scattering of light by the first part of the blood sample in the detection tube to obtain the red blood cell sedimentation rate of the first part of the blood sample ；

   The blood routine detection module includes a blood routine detection pool and a blood routine detection device. The blood routine detection pool is connected to the blood separation valve and is used to provide a testing place for the second part of blood samples distributed by the blood separation valve. The blood routine detection device is used to perform blood routine detection on the second part of blood samples in the blood routine detection pool.
2. The sample analyzer of claim 1, wherein the erythrocyte sedimentation rate detection module detects the erythrocyte sedimentation rate of the first part of the blood sample and the blood routine detection module detects the blood of the second part of the blood sample. The time of the conventional parameters overlaps.
3. The sample analyzer according to claim 1 or 2, wherein the blood separation valve comprises:

   A liquid inlet connected to the sampler through the front pipeline, and the first power device drives the blood sample collected by the sampler to flow into the blood separation valve through the liquid inlet;

   A first liquid separation port connected to the detection pipeline, and the first liquid separation opening is used for the first part of the blood sample distributed by the blood separation valve to flow into the detection pipeline;

   A second liquid separation port connected to the routine blood detection pool, and the second liquid separation opening is used for the second part of blood sample distributed by the blood separation valve to flow into the routine blood detection pool;

   The liquid outlet is connected to the first power device through the rear pipeline, and the first power device drives the blood sample in the blood separation valve to flow from the liquid outlet into the rear pipeline .
4. The sample analyzer of claim 3, wherein the erythrocyte sedimentation rate detection module further comprises an erythrocyte sedimentation rate detection pool independent of the routine blood sedimentation pool, and the detection pipeline passes through the erythrocyte sedimentation rate detection pool and the separation pool. The blood valve is connected, and the ESR detection pool is used to receive the first part of blood sample distributed by the blood separation valve.
5. The sample analyzer according to any one of claims 1 to 4, wherein the erythrocyte sedimentation rate detection module further comprises a second power device connected to the detection pipeline, and the second power device is used for Drive the first part of blood sample distributed by the blood separation valve to flow into the detection tube, and make the first part of blood sample flow to the detection area in the detection tube, stop moving and keep still , So that the optical detection device can detect the erythrocyte sedimentation rate of the first part of the blood sample.
6. The sample analyzer according to claim 1 or 2, wherein a part of the rear pipeline is the detection pipeline, wherein the first power device is used to transfer the blood sample collected by the sampler Withdraw into the blood separation valve until a part of the blood sample flows into the detection pipeline of the rear pipeline.
7. The sample analyzer according to any one of claims 1 to 6, wherein the optical detection device comprises:

   A light emitter, the light emitter is located on one side of the detection area of the detection pipeline, and is used to irradiate the first part of the blood sample in the detection area,

   A light receiver, which is located on the other side of the detection area of the detection pipeline, and is used to detect the change amount of the light emitted by the light transmitter after irradiating the first part of the blood sample.
8. The sample analyzer according to any one of claims 1 to 7, wherein the detection pipeline is arranged horizontally.
9. The sample analyzer according to any one of claims 1 to 8 (a number of citations), further comprising a liquid path support module for distributing the sample and the erythrocyte sedimentation rate detection module And the blood routine detection module provides liquid path support.
10. A sample analysis method, characterized in that the sample analysis method includes:

    Sampling distribution step: the first power device drives the sampler to collect blood samples and draws the blood samples in the sampler into the blood separation valve through the front pipeline connecting the sampler and the blood separation valve, Thus, the blood sample is divided into a first part of blood sample and a second part of blood sample and allocated to the erythrocyte sedimentation rate detection module and the blood routine detection module respectively;

    Red blood cell sedimentation rate detection step: The erythrocyte sedimentation rate detection module irradiates the first part of the blood sample with light, and detects the degree of absorption or scattering of the light by the first part of the blood sample to obtain the red blood cell sedimentation rate of the first part of the blood sample ；

    Routine blood detection step: The routine blood detection device detects the blood routine parameters of the second part of the blood sample.
11. The sample analysis method according to claim 10, wherein the time for the erythrocyte sedimentation rate detection module to detect the erythrocyte sedimentation rate of the first part of blood sample is different from the time for the blood routine detection module to detect the blood sedimentation rate of the second part of blood sample. The time of the conventional parameters overlaps.
12. The sample analysis method according to claim 10 or 11, wherein the sample distribution step comprises:

    The blood separation valve distributes the first part of the blood sample to the detection pipeline of the erythrocyte sedimentation rate detection module or the erythrocyte sedimentation detection pool connected to the detection pipeline through its first sample transmission channel;

    At the same time, the blood separation valve distributes the second part of blood samples to the blood routine detection pool of the blood routine detection module through its second sample transmission channel.
13. The sample analysis method according to claim 10 or 11, wherein the sample distribution step comprises:

    The first power device draws the blood sample in the sampler into the blood separation valve through the front pipeline until a part of the blood sample flows to connect the first power device and the blood separation valve In the connected back pipeline, the blood sample in the back pipeline is the first part of blood sample;

    Then, the blood separation valve distributes the second part of the blood sample to the blood routine detection pool of the blood routine detection module through its sample transmission channel.
14. The sample analysis method according to any one of claims 10 to 13, wherein the time when the erythrocyte sedimentation rate detection module starts to detect the erythrocyte sedimentation rate of the first part of the blood sample and the blood routine detection module starts the detection station The blood routine parameters of the second part of blood samples have the same or different time.
15. The sample analysis method according to any one of claims 10 to 14, wherein the blood routine detection module is first activated to perform blood routine parameter detection on the second part of the blood sample, and then the erythrocyte sedimentation rate detection module is activated The erythrocyte sedimentation rate is detected on the first part of blood sample.
16. The sample analysis method according to any one of claims 10 to 15, wherein the sample analysis method is applied to the sample analyzer according to any one of claims 1 to 9.

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