WO2021093315A1 - Composition à fonction hépatoprotectrice, son procédé de préparation et application associée - Google Patents

Composition à fonction hépatoprotectrice, son procédé de préparation et application associée Download PDF

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Publication number
WO2021093315A1
WO2021093315A1 PCT/CN2020/094510 CN2020094510W WO2021093315A1 WO 2021093315 A1 WO2021093315 A1 WO 2021093315A1 CN 2020094510 W CN2020094510 W CN 2020094510W WO 2021093315 A1 WO2021093315 A1 WO 2021093315A1
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WO
WIPO (PCT)
Prior art keywords
parts
composition
food
hawthorn
chrysanthemum
Prior art date
Application number
PCT/CN2020/094510
Other languages
English (en)
Chinese (zh)
Inventor
肖伟
丁艳
刘世娟
王婧
柏伟荣
王振东
邓辰辰
Original Assignee
江苏康仁医药科技开发有限公司
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Publication date
Application filed by 江苏康仁医药科技开发有限公司 filed Critical 江苏康仁医药科技开发有限公司
Publication of WO2021093315A1 publication Critical patent/WO2021093315A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
    • A23G3/48—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/38—Other non-alcoholic beverages
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/385—Concentrates of non-alcoholic beverages
    • A23L2/39—Dry compositions
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the invention relates to the technical fields of medicines, health products and foods, and in particular to a composition with liver protection function and a preparation method and application thereof.
  • One of the objectives of the present invention is to provide a composition with hepatoprotective function.
  • the composition and the raw materials used can be directly ground into powder, or it can be an extract prepared by conventional means or other forms.
  • the composition In terms of parts by weight, it includes: 150-300 parts of Pueraria lobata, 200-350 parts of hawthorn, 100-250 parts of dandelion, 100-200 parts of chrysanthemum, and 100-200 parts of tangerine peel.
  • the composition includes: 200-300 parts by weight of Pueraria lobata root, 200-300 parts of hawthorn, 100-200 parts of dandelion, 100-150 parts of chrysanthemum, and 100-150 parts of tangerine peel.
  • the composition includes 180-220 parts by weight of Pueraria lobata, 280-320 parts of hawthorn, 180-220 parts of dandelion, 140-160 parts of chrysanthemum, and 140-160 parts of tangerine peel.
  • the composition includes 200 parts by weight of Pueraria lobata, 300 parts of hawthorn, 200 parts of dandelion, 150 parts of chrysanthemum, and 150 parts of tangerine peel.
  • the present invention also proposes the application of any of the previous compositions in the preparation of medicines, health products or foods with hepatoprotective function.
  • the liver protection function may be, for example, preventing or reducing liver damage caused by alcohol.
  • the present invention also proposes a medicine, health care product or food containing the composition with liver protection function as any one of the previous items.
  • the medicine, health product or food is selected from beverages, capsules, compressed candies, tablets, powders, teas, granules, oral liquids or granules.
  • the medicine, health product or food contains pharmaceutically or food-acceptable auxiliary materials or additives; for example, it may be erythritol, microcrystalline cellulose, strawberry fruit powder, maltodextrin, stevia Glycoside, magnesium stearate.
  • the acceptable excipients or additives include 1 to 3 parts of erythritol, 50 to 80 parts of microcrystalline cellulose, 10 to 15 parts of strawberry fruit powder, and 200 to 200 parts of maltodextrin. 300 parts, 0.5 ⁇ 1 steviol glycosides, 10 ⁇ 30 parts magnesium stearate.
  • the medicine, health care product or food includes microcrystalline cellulose and maltodextrin; wherein, the microcrystalline cellulose is preferably 60 to 70 parts, and the maltodextrin is preferably 200 parts. ⁇ 300 copies.
  • the present invention also provides a method for preparing a health care product or food.
  • the preparation method includes the following steps:
  • the mixed powder is stirred, it is wet-granulated with alcohol and dried; the drying temperature is optionally 60°C, and the drying time is 50-70 minutes, until the moisture of the wet granules is below 5%;
  • Granulation and total mixing the dried granules are granulated, and the mixed magnesium stearate and microcrystalline cellulose are mixed with the granular granules, and the mixing time is optionally 25-30 minutes;
  • the preparation method of the compressed candy includes the following steps:
  • Granulation The above mixed powder is made into soft material with 90% ethanol, and granulated with an 18-mesh sieve;
  • Drying dry the wet granules at 60°C for 60 minutes;
  • Granulation and tableting The dried granules are sized with a 20-mesh sieve, and then put into a mixer, and then magnesium stearate and microcrystalline cellulose powder are added in sequence, mixed, and the mixing time is 30 Minutes, tablet.
  • the present invention proposes a composition with liver-protecting function.
  • Pueraria lobata root has the functions of clearing the meridians, activating collaterals, relieving alcohol and toxins, producing body fluid and quenching thirst to quench thirst caused by alcohol, which belongs to the emperor's medicine.
  • Hawthorn has the functions of eliminating the masses and strengthening the stomach, promoting qi and dispersing blood stasis, reducing turbidity and lowering lipids, and can achieve the purpose of promoting body fluids and quenching thirst; Chrysanthemum has the effects of calming the liver and improving eyesight, clearing away heat and detoxification, and the above three are the ministerial medicine. Tangerine peel has the function of regulating qi and invigorating the spleen and is an adjuvant. The above five herbs are shared to achieve the effects of producing body fluids and quenching thirst, regulating qi and eliminating pathogenic factors, and relieving alcohol and poison.
  • the present invention also prepares tableted candies by adding auxiliary materials and process adjustment, adding fruit powder and flavoring agents to increase the pleasant taste of the product.
  • the tableted candy for relieving alcohol and protecting the liver provided by the present invention can achieve the effects of sobering up and relieving alcohol by accelerating the metabolism of alcohol, and it can also improve the abnormal metabolism caused by alcohol, regulate human body functions, and has the advantages of clearing heat and detoxification, producing body fluids and quenching thirst And the effect of invigorating the spleen and stomach and protecting the liver reduces the occurrence of alcoholic liver injury.
  • Anhydrous ethanol (Nanjing Chemical Reagent Co., Ltd., batch number 171225545K); AST kit (Nanjing Jiancheng Institute of Biological Engineering, batch number 20171024); ALT kit (Nanjing Jiancheng Institute of Biological Engineering, batch number 20171025); GSH reagent Kit (Nanjing Jiancheng Institute of Bioengineering, batch number 20171211); ADH kit (Nanjing Jiancheng Institute of Bioengineering, batch number 20171123); MDA kit (Nanjing Jiancheng Institute of Bioengineering, batch number 20171203).
  • mice Take 40 rats, and divide them into groups (experimental group) and control group, 20 rats in each group.
  • rats were intragastrically administered with the sample prepared in Example 1 at 16 g (based on the amount of the preparation)/kg, and the administration volume was 40 ml/kg, 3 times a day for 15 days.
  • the vehicle control group was treated with an equal volume of saline in the same way.
  • Preliminary pathological examinations were performed on the animals that died and the animals killed during the experiment. The tissues and organs of each animal were observed and recorded for abnormalities such as changes in volume, color, and texture.
  • the experimental drug group and the control group are in good mental state.
  • the rats have no abnormal body size, normal behavior, brighter coat, normal breathing, no abnormal body size, eyes, skin, nose, nose, ears, etc. There was no abnormal secretion, redness, swelling, ulceration in the perineum, granular stool, and no death.
  • ALT alanine aminotransferase
  • AST aspartate aminotransferase
  • GSH glutathione
  • MDA malondialdehyde
  • ADH alcohol dehydrogenase
  • composition of the present invention can increase the activity of GSH and ADH in liver tissue and reduce the activity of ALT and AST in serum, indicating that it has obvious anti-alcohol and liver-protecting effects.
  • Granulation The above-mentioned mixed powder is made into a soft material with 90% ethanol, and granulated with an 18-mesh sieve.
  • Drying Put the wet granules on the drying bed, the inlet air temperature is 60°C, and dry for 60min.
  • Granulation and tableting use a 20-mesh sieve to sizing the dried granules, put them in a mixer, add 10 parts of magnesium stearate and 70 parts of fine microcrystalline cellulose powder, mix, and mix time For 30 minutes.
  • the qualified granules are added to the material container of the tablet press for tablet compression.
  • a total of 1000 parts of medicinal materials are used to obtain 241.5 parts of tableted candies, each of which is about 0.35 to 0.4 g.
  • Granulation The above-mentioned mixed powder is made into a soft material with 90% ethanol, and granulated with an 18-mesh sieve.
  • Drying Put the wet granules on the drying bed, the inlet air temperature is 60°C, and dry for 60min.
  • Granulation and tableting The dried granules are sized with a 20-mesh sieve, and then placed in a mixer, and then 10 parts of magnesium stearate and 60 parts of microcrystalline cellulose are added, and the mixing time is 30 minute.
  • the qualified granules are added to the material container of the tablet press for tablet compression.
  • a total of 1000 parts of medicinal materials are used to obtain 241.5 parts of tableted candies, and each tablet is about 0.35 to 0.40 g.

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Botany (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Mycology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

L'invention concerne une composition ayant une fonction hépatoprotectrice, un procédé de préparation associé et une application associée. La composition comprend Puerariae Lobatae Radix, Crataegi Fructus, Taraxaci Herba, Chrysanthemi Flos, et Citri Reticulatae Pericarpium.
PCT/CN2020/094510 2019-11-12 2020-06-05 Composition à fonction hépatoprotectrice, son procédé de préparation et application associée WO2021093315A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201911103138.3A CN110934914A (zh) 2019-11-12 2019-11-12 一种具有保肝功能的组合物及其制备方法和应用
CN201911103138.3 2019-11-12

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Publication Number Publication Date
WO2021093315A1 true WO2021093315A1 (fr) 2021-05-20

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CN (1) CN110934914A (fr)
WO (1) WO2021093315A1 (fr)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN115812826A (zh) * 2022-12-29 2023-03-21 烟台东宇海珍品有限公司 一种海参花压片糖果及其制备工艺

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110934914A (zh) * 2019-11-12 2020-03-31 江苏康缘药业股份有限公司 一种具有保肝功能的组合物及其制备方法和应用
CN114698842A (zh) * 2022-05-21 2022-07-05 于永涛 一种养肝护肝的参茸果组合物及其制备方法
CN115998823A (zh) * 2023-01-10 2023-04-25 汉方传承健康管理研究院(河南)有限公司 一种综合调理炎性体质的中药营养组合物

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CN106900902A (zh) * 2015-12-22 2017-06-30 史晓强 一种便携式解酒保肝茶包
CN110934914A (zh) * 2019-11-12 2020-03-31 江苏康缘药业股份有限公司 一种具有保肝功能的组合物及其制备方法和应用

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CN104068175A (zh) * 2014-07-03 2014-10-01 句容茅宝葛业有限公司 一种葛根山楂茶及其制备方法
CN105767401A (zh) * 2016-05-17 2016-07-20 商皓 一种解酒护肝保健茶及其制备工艺
CN110074243A (zh) * 2019-04-29 2019-08-02 海南路易丹尼生物科技有限公司 一种具有解酒和保护肝脏功能的压片糖果

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CN106900902A (zh) * 2015-12-22 2017-06-30 史晓强 一种便携式解酒保肝茶包
CN110934914A (zh) * 2019-11-12 2020-03-31 江苏康缘药业股份有限公司 一种具有保肝功能的组合物及其制备方法和应用

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115812826A (zh) * 2022-12-29 2023-03-21 烟台东宇海珍品有限公司 一种海参花压片糖果及其制备工艺

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