CN106036834A - 一种含青梅的具有改善睡眠功效的保健食品组合物 - Google Patents
一种含青梅的具有改善睡眠功效的保健食品组合物 Download PDFInfo
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Abstract
本发明属于保健品领域,涉及一种含青梅的具有改善睡眠功效的保健食品组合物。本发明保健食品组合物包括以下重量份数的制备原料:青梅25‑32份、百合21‑30份、桂圆23‑30份、蜂蜜12‑25份、阿胶10‑23份、酸枣仁10‑24份、玫瑰花12‑24份、荆芥6‑10份、熟地黄4‑9份、麦冬3‑8份、核桃6‑8份、夜交藤5‑9份及珍珠母4‑10份。本发明含青梅的具有改善睡眠功效的保健食品组合物组方合理,协同作用强,具有补脾益气、养血安神、滋阴降火、疏肝理气的功效,能够有效地改善睡眠。
Description
技术领域
本发明属于保健品领域,尤其涉及一种含青梅的具有改善睡眠功效的保健食品组合物。
背景技术
睡眠是生命的需要,人人都应该遵循正常睡眠规律,如果这种最基本的睡眠规律出现紊乱,就会发生睡眠异常与疾病。
睡眠疾病包括的内容有很多,可以分成三大类:一类是睡得太少,失眠;失眠症指持续相当长时间的对睡眠的质和量不满意的状况,不能以统计上的正常睡眠时间作为诊断失眠的主要标准。对失眠有忧虑或恐惧心理可形成恶性循环,从而使症状持续存在。一类是睡得太多,嗜睡;白天睡眠过多,并非睡眠不足所致,不是药物、脑器质性疾病或躯体疾病所致,也不是某种精神障碍(如神经衰弱、抑郁症)的一部分。另一类是睡眠中出现异常行动,所谓异常睡眠;异常睡眠主要包括睡行症、夜惊和梦魇。睡行症通常出现在睡眠的前1/3段的深睡期,起床在室内或户外行走,或同时做些白天的常规活动,一般没有语言活动,询问也不回答,多能自动回到床上继续睡觉,次晨醒来不能回忆,多见于儿童少年。夜惊是指幼儿在睡眠中突然惊叫、哭喊,伴有惊恐表情和动作,以及心率增快、呼吸急促、出汗、瞳孔扩大等植物神经症状。通常在晚间睡眠后较短时间内发作,每次发作持续1~10分钟。梦魇是指从睡眠中为噩梦突然惊醒,对梦境中的恐怖内容能清晰回忆,犹心有余悸。通常在晚间睡眠的后期发作。西医一般采用多塞平,阿米替林,氟西泮,苯海拉明,异丙嗪等,但此些药物,若是长期使用,容易产生药物依赖性。
中医认为睡眠疾病病因复杂,多与脑、心肾、肝胆、脾胃等脏腑相关。思虑劳倦太过,阴血暗耗,久病耗血,外伤失血,年迈血少,致血虚而脑神失养;禀赋不足,房劳久病,心火上炎,肾水下亏,水不济火,心肾不交;七情所伤,肝郁化火,心虚胆怯,决断无权;饮食不节,或宿食内停,致胃气不和,生痰蕴热,致神志不宁,皆可导致睡眠疾病。
中国专利CN103202478B公开了了一种改善睡眠的保健食品,该保健食品由西洋参、灵芝、五味子、茯苓和酸枣仁组成。该保健食品原料成本高,效果起效慢,改善睡眠效果不明显,需长期服用。
发明内容
本发明要解决的技术问题是提供一种含青梅的具有改善睡眠功效的保健食品组合物,本发明提供的含青梅的具有改善睡眠功效的保健食品组合物组方合理,协同作用强,具有补脾益气、养血安神、滋阴降火、疏肝理气的功效,在改善睡眠方面,具有效果好,周期短、适用范围广的优点。
本发明含青梅的具有改善睡眠功效的保健食品组合物包括以下重量份数的制备原料:
青梅25-32份、百合21-30份、桂圆23-30份、蜂蜜12-25份、阿胶10-23份、酸枣仁10-24份、玫瑰花12-24份、荆芥6-10份、熟地黄4-9份、麦冬3-8份、核桃6-8份、夜交藤5-9份及珍珠母4-10份。
进一步地,所述含青梅的具有改善睡眠功效的保健食品组合物包括以下重量份数的制备原料:青梅25份、百合21份、桂圆23份、蜂蜜12份、阿胶10份、酸枣仁10份、玫瑰花12份、荆芥6份、熟地黄4份、麦冬3份、核桃6份、夜交藤5份及珍珠母4份。
进一步地,所述含青梅的具有改善睡眠功效的保健食品组合物包括以下重量份数的制备原料:青梅28份、百合25份、桂圆27份、蜂蜜18份、阿胶15份、酸枣仁17份、玫瑰花18份、荆芥8份、熟地黄6份、麦冬5份、核桃7份、夜交藤7份及珍珠母7份。
进一步地,所述含青梅的具有改善睡眠功效的保健食品组合物包括以下重量份数的制备原料:青梅32份、百合30份、桂圆30份、蜂蜜25份、阿胶23份、酸枣仁24份、玫瑰花24份、荆芥10份、熟地黄9份、麦冬8份、核桃8份、夜交藤9份及珍珠母10份。
进一步地,所述含青梅的具有改善睡眠功效的保健食品组合物制成胶囊剂、糖浆剂、丸剂、口服液或片剂等。
本发明还提供一种本发明所述含青梅的具有改善睡眠功效的保健食品组合物的制备方法,包含下述步骤:
S1:称取青梅、百合、桂圆、酸枣仁、玫瑰花、荆芥、熟地黄、麦冬、核桃、夜交藤及珍珠母,粉碎,加入总药材6-10倍量水浸泡2-3小时,武火煎煮沸腾30-40分钟,再用文火煎煮2-3小时,过滤,得到滤液,往滤渣中加入2-4倍量水,武火煎煮沸腾15-30分钟,再用文火煎煮1-2小时,过滤,得到滤液,合并两次滤液,滤液浓缩至50℃-60℃下相对密度为1.20-1.35的稠膏,减压干燥,粉碎后过100-200目筛,得到均匀的细粉1;
S2:称取阿胶,将阿胶粉碎,过100-200目筛,与细粉1混合,得细粉2;
S3:称取蜂蜜,加1-2倍量40℃-50℃温水化开后,冷却至室温,加入到细粉2中,搅拌混匀,得稠状物;
S4:将S3制得的稠状物加入辅料后制成保健食品。
本发明提供的含青梅的具有改善睡眠功效的保健食品组合物所用制备原料的来源及功效:
青梅:本品为蔷薇科植物梅的干燥近成熟果实。味酸、涩,性平;归肝、脾、肺、大肠经;青梅止咳、涩肠止泻、除烦静心、生津止渴;主要用于肺虚久咳,久痢滑肠,虚热消渴。
百合:本品为百合科植物卷丹、百合或细叶百合的干燥肉质鳞叶。味甘,性寒;归心、肺经;养阴润肺,清心安神;主要用于阴虚久咳,痰中带血,虚烦惊悸,失眠多梦,精神恍惚。
桂圆:本品为无患子科龙眼属植物龙眼果实。味甘,性温;归心、脾经;开胃、养血益脾、补心安神、补虚长智;用于心脾虚损、气血不足所致的失眠、健忘、惊悸、眩晕。
蜂蜜:本品为蜜蜂科昆虫中华蜜蜂或意大利蜂所酿的蜜。味甘,性平;归肺、脾、大肠经;补中,润燥,止痛,解毒;主要用于脘腹虚痛,肺燥干咳,肠燥便秘,外治疮疡不敛,水火烫伤。
阿胶:本品为马科动物驴的皮经煎煮、浓缩制成的固体胶。味甘,性平;归肺、肝、肾经;补血滋阴,润燥,止血。主要用于血虚萎黄,眩晕心悸,肌痿无力,心烦不眠,虚风内动,肺燥咳嗽,劳嗽咯血,吐血尿血,便血崩漏,妊娠胎漏。
酸枣仁:本品为鼠李科植物酸枣的干燥成熟种子。味甘、酸,性平;归肝、胆、心经;补肝,宁心,敛汗,生津;主要用于虚烦不眠,惊悸多梦,体虚多汗,津伤口渴。
玫瑰花:本品为蔷薇科植物玫瑰的干燥花蕾。味甘、微苦,性温;归肝、脾经;行气解郁,和血,止痛;主要用于肝胃气痛,食少呕恶,月经不调,跌扑伤痛。
荆芥:本品为唇形科植物荆芥的干燥地上部分。味辛,性微温;归肺、肝经;解表散风,透疹;主要用于感冒,头痛,麻疹,风疹,疮疡初起。
熟地黄:本品为生地黄的炮制加工品。味甘,性微温;归肝、肾经;滋阴补血,益精填髓;主要用于肝肾阴虚,腰膝酸软,骨蒸潮热,盗汗遗精,内热消渴,血虚萎黄,心悸怔忡,眩晕,耳鸣。
麦冬:本品为百合科植物沿阶草的块根。味微苦,性寒;归肺、胃、心经;养阴润肺,清心除烦,益胃生津;主要用于阴虚肺燥,咳嗽痰粘,胃阴不足,口燥咽干。
核桃:本品为胡桃科植物核桃楸的种仁。味甘,性温;归肾、肺经;敛肺平喘;温补肾阳,润肠通便;主要用于腰膝酸软、隐痛,虚喘久咳。
夜交藤:本品为蓼科植物何首乌的藤茎或带叶藤茎。味微苦,性平;归入心、肝经;养心安神,祛风,通络主要用于失眠,多梦,血虚身痛,肌肤麻木,风湿痹痛,风疹瘙痒。
珍珠母:本品为蚌科动物三角帆蚌、褶纹冠蚌或珍珠贝科动物马氏珍珠贝的贝壳。味咸,性寒;归肝、心经;平肝潜阳,定惊明目;主要用于头痛眩晕,烦躁失眠,肝热目赤,肝虚目昏。
本发明提供的含青梅的具有改善睡眠功效的保健食品组合物中,青梅、百合、桂圆、蜂蜜、阿胶具有养阴润肺,清心安神,补虚长智,补血滋阴的功效;酸枣仁、玫瑰花、荆芥、熟地黄补肝,宁心,行气解郁,解表散风;麦冬、核桃、夜交藤及珍珠母养阴润肺,清心除烦,温补肾阳,养心安神,原料配伍合理、科学,各组分协同起补脾益气、养血安神、滋阴降火、疏肝理气的功效,对睡眠病症具有显著的改善效果。
与现有技术相比,本发明具有如下技术优势:
1、本发明提供的含青梅的具有改善睡眠功效的保健食品组合物原料来源广,制备方法简单易行,生产成本低,质量稳定,适用性广;
2、本发明提供的含青梅的具有改善睡眠功效的保健食品组合物具有补脾益气、养血安神、滋阴降火、疏肝理气的功效,对睡眠状况改善效果明显、稳定。
具体实施方式
本领域技术人员应理解,以下实施例中所公开的技术代表本发明人发现的在本发明的实践中发挥良好作用的技术。然而,在所公开的具体实施方案中可以做出许多改变,并仍然获得相同或相似的结果,而不脱离本发明的精神和范围。
实施例1:
本发明实施例1含青梅的具有改善睡眠功效的保健食品组合物包括以下重量份数的制备原料:
青梅25份、百合21份、桂圆23份、蜂蜜12份、阿胶10份、酸枣仁10份、玫瑰花12份、荆芥6份、熟地黄4份、麦冬3份、核桃6份、夜交藤5份及珍珠母4份。
制备方法如下:
S1:称取青梅、百合、桂圆、酸枣仁、玫瑰花、荆芥、熟地黄、麦冬、核桃、夜交藤及珍珠母,粉碎,加入总药材8倍量水浸泡2.5小时,武火煎煮沸腾30分钟,再用文火煎煮2.5小时,过滤,得到滤液,往滤渣中加入3倍量水,武火煎煮沸腾15分钟,再用文火煎煮1小时,过滤,得到滤液,合并两次滤液,滤液浓缩至60℃下相对密度为1.35的稠膏,减压干燥,粉碎后过100目筛,得到均匀的细粉1;
S2:称取阿胶,将阿胶粉碎,过100目筛,与细粉1混合,得细粉2;
S3:称取蜂蜜,加2倍量40℃温水化开后,冷却至室温,加入到细粉2中,搅拌混匀,得稠状物;
S4:将S3制得的稠状物加入辅料后制成胶囊剂,折合生药含量1.5g/粒。
实施例2:
本发明实施例2含青梅的具有改善睡眠功效的保健食品组合物包括以下重量份数的制备原料:青梅28份、百合25份、桂圆27份、蜂蜜18份、阿胶15份、酸枣仁17份、玫瑰花18份、荆芥8份、熟地黄6份、麦冬5份、核桃7份、夜交藤7份及珍珠母7份。
制备方法同实施例1。
实施例3:
本发明实施例3含青梅的具有改善睡眠功效的保健食品组合物包括以下重量份数的制备原料:青梅32份、百合30份、桂圆30份、蜂蜜25份、阿胶23份、酸枣仁24份、玫瑰花24份、荆芥10份、熟地黄9份、麦冬8份、核桃8份、夜交藤9份及珍珠母10份。
制备方法同实施例1。
对比例1:
本发明对比例1保健食品组合物包括以下重量份数的制备原料:
青梅32份、百合30份、丹参30份、蜂蜜25份、阿胶23份、酸枣仁24份、玫瑰花24份、荆芥10份、熟地黄9份、麦冬8份、核桃8份、夜交藤9份及珍珠母10份。
制备方法同实施例3。
与实施例3的区别在于,将桂圆替换为丹参。
对比例2:
本发明对比例2保健食品组合物包括以下重量份数的制备原料:
青梅36份、百合34份、桂圆30份、蜂蜜25份、阿胶23份、酸枣仁24份、玫瑰花24份、荆芥10份、熟地黄9份、麦冬8份、夜交藤9份及珍珠母10份。
制备方法同实施例3。
与实施例3的区别在于,没有添加核桃,增加了青梅和百合的用量。
本发明保健食品组合物的药效学考察
本发明含青梅的具有改善睡眠功效的保健食品组合物对试验性失眠模型大鼠睡眠的改善作用
目的:本试验采用对氯苯丙氨酸(PCPA)腹腔注射的方法构建失眠大鼠模型,用本发明含青梅的具有改善睡眠功效的保健食品组合物干预治疗,以安神胶囊作为阳性对照,观察试验动物的一般状态及通过戊巴比妥钠翻正试验考察本发明含青梅的具有改善睡眠功效的保健食品组合物对失眠模型大鼠睡眠潜伏期、睡眠总时间的影响。
1、试验动物:Wistar大鼠90只,体重220-230g,雌雄各半,购买自中山大学试验动物研究中心,随机分为2组,模型构建组80只,正常对照组10只。
2、试验模型建立:模型构建组80只Wistar大鼠按照400mg/kg用量腹腔注射对氯苯丙氨酸(PCPA)混悬液,PCPA用弱碱性生理盐水配置,连续注射2天,正常组10只Wistar大鼠腹腔注射等体积弱碱性生理盐水,第一次腹腔注射PCPA36h后,大鼠出现昼夜节律缺失,日间与夜晚皆活动不断,经戊巴比妥钠翻正试验,正常对照组与模型构建组大鼠睡眠潜伏期、总睡眠时间有统计学意义,则造模成功。最终构建成功72只试验性失眠大鼠模型,随机选取70只试验性失眠模型大鼠,分为7组,分别为模型对照组、阳性对照组、实施例1-3组、对比例1-2组,每组10只。
3、试验药物及给药方案:
正常对照组:灌胃给予同体积的生理盐水;
模型对照组:灌胃给予同体积的生理盐水;
阳性对照组:安神胶囊(长春海外制药集团有限公司,国药准字Z20073024),去胶囊壳后将内容物用水调配成混悬液,取1组试验性失眠模型大鼠,按0.3g/kg的剂量每天灌胃给药1次,连续给药30天。
实施例1组:试验药物为本发明实施例1制得的胶囊剂,去胶囊壳后将内容物用水调配成混悬液,取1组试验性失眠模型大鼠,按0.3g/kg的剂量每天灌胃给药1次,连续给药30天。
实施例2组:试验药物为本发明实施例2制得的胶囊剂,给药方案同实施例1组。
实施例3组:试验药物为本发明实施例3制得的胶囊剂,给药方案同实施例1组。
对比例1组:试验药物为本发明对比例1制得的胶囊剂,给药方案同实施例1组。
对比例2组:试验药物为本发明对比例2制得的胶囊剂,给药方案同实施例1组。
4、试验方法
给药期间观察大鼠的精神状态、皮毛颜色、取食量、饮水量、对外界刺激的反应、死亡情况等;分别于给药前、试验结束时称量体重,观察体重增加量;试验结束前12h,各组均腹腔注射戊巴比妥钠30mg/kg,提起大鼠尾巴,将大鼠腹部朝上放在垫块上,记录大鼠的睡眠潜伏期及睡眠持续时间,以翻正反射丧失为发生睡眠,以翻正反射恢复为觉醒。t检验进行组间统计比较,结果见表1,表2。
5、试验结果
(1)一般状态的观察:试验结束时,正常对照组大鼠精神状态良好,活动机灵,反应敏捷,毛发有光泽,体重明显增加;模型对照组大鼠精神亢奋,毛硬粗糙、毛竖起无光泽,易激惹,饮食量明显减少、饮水明显增多,消瘦;实施例1、2、3组和阳性对照组大鼠精神状态、活动及反应情况接近正常对照组大鼠,体重增长也接近正常对照组;对比例1、2组大鼠精神状态、活动及反应情况不如实施例1、2、3组,体重几乎无增长。
(2)体重变化:
表1 各组大鼠试验结束时体重增加量的比较(g)
组别 | N | 体重增加量 |
正常对照组 | 10 | 17.22±1.72 |
模型对照组 | 10 | 3.26±1.48** |
阳性对照组 | 10 | 9.60±3.62*# |
实施例1组 | 10 | 10.52±3.50*# |
实施例2组 | 10 | 16.26±3.94##Δ |
实施例3组 | 10 | 12.40±3.44*## |
对比例1组 | 10 | 9.26±3.21*# |
对比例2组 | 10 | 7.24±2.58**# |
注:与正常对照组比较,*P<0.05,**P<0.01;与模型对照组比较,#P<0.05,##P<0.01,与阳性对照组比较,ΔP<0.05。
(3)睡眠潜伏期、睡眠持续时间
表2 各组大鼠试验结束时戊巴比妥钠翻正试验的比较(min)
组别 | N | 睡眠潜伏期(min) | 睡眠持续时间(min) |
正常对照组 | 10 | 10.62±3.62 | 108.40±14.00 |
模型对照组 | 10 | 23.48±4.00** | 72.60±14.62** |
阳性对照组 | 10 | 14.26±3.38*# | 95.24±5.72*# |
实施例1组 | 10 | 15.26±4.06*# | 92.42±6.22*# |
实施例2组 | 10 | 13.60±3.20## | 102.82±8.24##Δ |
实施例3组 | 10 | 14.06±3.26*# | 98.02±8.32*# |
对比例1组 | 10 | 20.21±2.01**Δ | 80.22±9.56* |
对比例2组 | 10 | 19.88±2.04**Δ | 85.20±8.03* |
注:与正常对照组比较,*P<0.05,**P<0.01;与模型对照组比较,#P<0.05,##P<0.01,与阳性对照组比较,ΔP<0.05。
6.试验结论:由表1可知,试验结束时,模型对照组大鼠体重增加量不明显,与正常对照组相比,具有明显差异(P>0.01)。与模型对照组相比,各给药组大鼠体重均显著增加(P<0.05),但对比例1组和对比例2组的体重增长量不如本发明实施例组。本发明实施例2组大鼠的体重增长量与正常对照组相比无明显差异(P>0.05)。由戊巴比妥钠翻正试验结果可知,阳性对照组、实施例1、2、3组大鼠睡眠潜伏期明显低于模型对照组(P<0.05),其中,实施例2组大鼠的睡眠潜伏期与正常对照组相比无明显差异(P>0.05),而实施例1、2、3组大鼠睡眠潜伏期阳性对照组相比无明显差异(P>0.05),对比例1组和对比例2组大鼠睡眠潜伏期显著高于阳性对照组相(P<0.05);阳性对照组、实施例1、3组大鼠睡眠持续时间明显低于正常对照组(P<0.05),但显著高于模型对照组(P<0.05),其中,实施例2组大鼠睡眠持续时间与正常组相比无明显差别(P>0.05)。以上结果说明,实施例2为本发明最佳实施例,本发明含青梅的保健食品组合物配伍合理,改善睡眠功效显著。
Claims (6)
1.一种含青梅的具有改善睡眠功效的保健食品组合物,其特征在于,所述含青梅的具有改善睡眠功效的保健食品组合物包括以下重量份数的制备原料:
青梅25-32份、百合21-30份、桂圆23-30份、蜂蜜12-25份、阿胶10-23份、酸枣仁10-24份、玫瑰花12-24份、荆芥6-10份、熟地黄4-9份、麦冬3-8份、核桃6-8份、夜交藤5-9份及珍珠母4-10份。
2.如权利要求1所述的含青梅的具有改善睡眠功效的保健食品组合物,其特征在于,所述含青梅的具有改善睡眠功效的保健食品组合物包括以下重量份数的制备原料:
青梅25份、百合21份、桂圆23份、蜂蜜12份、阿胶10份、酸枣仁10份、玫瑰花12份、荆芥6份、熟地黄4份、麦冬3份、核桃6份、夜交藤5份及珍珠母4份。
3.如权利要求1所述的含青梅的具有改善睡眠功效的保健食品组合物,其特征在于,所述含青梅的具有改善睡眠功效的保健食品组合物包括以下重量份数的制备原料:
青梅32份、百合30份、桂圆30份、蜂蜜25份、阿胶23份、酸枣仁24份、玫瑰花24份、荆芥10份、熟地黄9份、麦冬8份、核桃8份、夜交藤9份及珍珠母10份。
4.如权利要求1所述的含青梅的具有改善睡眠功效的保健食品组合物,其特征在于,所述含青梅的具有改善睡眠功效的保健食品组合物包括以下重量份数的制备原料:
青梅28份、百合25份、桂圆27份、蜂蜜18份、阿胶15份、酸枣仁17份、玫瑰花18份、荆芥8份、熟地黄6份、麦冬5份、核桃7份、夜交藤7份及珍珠母7份。
5.如权利要求1所述的含青梅的具有改善睡眠功效的保健食品组合物,其特征在于,所述含青梅的具有改善睡眠功效的保健食品组合物制成胶囊剂、糖浆剂、丸剂、口服液或片剂。
6.一种如权利要求1-4任一所述的含青梅的具有改善睡眠功效的保健食品组合物的制备方法,其特征在于,所述制备方法包含下述步骤:
S1:称取青梅、百合、桂圆、酸枣仁、玫瑰花、荆芥、熟地黄、麦冬、核桃、夜交藤及珍珠母,粉碎,加入总药材6-10倍量水浸泡2-3小时,武火煎煮沸腾30-40分钟,再用文火煎煮2-3小时,过滤,得到滤液,往滤渣中加入2-4倍量水,武火煎煮沸腾15-30分钟,再用文火煎煮1-2小时,过滤,得到滤液,合并两次滤液,滤液浓缩至50℃-60℃下相对密度为1.20-1.35的稠膏,减压干燥,粉碎后过100-200目筛,得到均匀的细粉1;
S2:称取阿胶,将阿胶粉碎,过100-200目筛,与细粉1混合,得细粉2;
S3:称取蜂蜜,加1-2倍量40℃-50℃温水化开后,冷却至室温,加入到细粉2中,搅拌混匀,得稠状物;
S4:将S3制得的稠状物加入辅料后制成保健食品。
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CN109363011A (zh) * | 2018-11-19 | 2019-02-22 | 惠州同富康生物科技有限公司 | 一种具有美白抗氧化护肝助睡眠作用的饮料及其制备方法 |
CN109363011B (zh) * | 2018-11-19 | 2021-12-14 | 惠州同富康生物科技有限公司 | 一种具有美白抗氧化护肝助睡眠作用的饮料及其制备方法 |
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