WO2021079813A1 - Organe en aluminium, bande de test pour immunochromatographie, et procédé de production d'un organe en aluminium - Google Patents

Organe en aluminium, bande de test pour immunochromatographie, et procédé de production d'un organe en aluminium Download PDF

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Publication number
WO2021079813A1
WO2021079813A1 PCT/JP2020/038847 JP2020038847W WO2021079813A1 WO 2021079813 A1 WO2021079813 A1 WO 2021079813A1 JP 2020038847 W JP2020038847 W JP 2020038847W WO 2021079813 A1 WO2021079813 A1 WO 2021079813A1
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WIPO (PCT)
Prior art keywords
aluminum
outer shell
aluminum member
mass
porous body
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PCT/JP2020/038847
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English (en)
Japanese (ja)
Inventor
裕太 清水
修平 榎
敏文 平
藤本　和也
Original Assignee
日本軽金属株式会社
東洋アルミニウム株式会社
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Application filed by 日本軽金属株式会社, 東洋アルミニウム株式会社 filed Critical 日本軽金属株式会社
Priority to JP2021554336A priority Critical patent/JP7235889B2/ja
Priority to CN202080073043.6A priority patent/CN114555869B/zh
Publication of WO2021079813A1 publication Critical patent/WO2021079813A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
    • C25D11/00—Electrolytic coating by surface reaction, i.e. forming conversion layers
    • C25D11/02—Anodisation
    • C25D11/04—Anodisation of aluminium or alloys based thereon
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F3/00—Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sintering; Apparatus specially adapted therefor ; Presses and furnaces
    • B22F3/10—Sintering only
    • B22F3/11—Making porous workpieces or articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F3/00—Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sintering; Apparatus specially adapted therefor ; Presses and furnaces
    • B22F3/24—After-treatment of workpieces or articles
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
    • C25D11/00—Electrolytic coating by surface reaction, i.e. forming conversion layers
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
    • C25D11/00—Electrolytic coating by surface reaction, i.e. forming conversion layers
    • C25D11/02—Anodisation
    • C25D11/04—Anodisation of aluminium or alloys based thereon
    • C25D11/18—After-treatment, e.g. pore-sealing
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
    • C25D11/00—Electrolytic coating by surface reaction, i.e. forming conversion layers
    • C25D11/02—Anodisation
    • C25D11/04—Anodisation of aluminium or alloys based thereon
    • C25D11/18—After-treatment, e.g. pore-sealing
    • C25D11/24—Chemical after-treatment
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms

Definitions

  • the present invention relates to an aluminum member, a test strip for immunochromatography, and a method for manufacturing the aluminum member.
  • test kit using immunochromatography has been known as an in-vitro diagnostic drug for quickly and easily testing infections such as influenza virus.
  • This test kit is positive when, for example, a sample collected from a living body is dropped into a predetermined position and both the test line and the control line can be visually confirmed, and only the control line can be visually confirmed. If it is, it indicates that it is negative.
  • the test kit includes a nitrocellulose membrane filter as a test strip for developing a sample.
  • the collected sample flows through the membrane filter due to the capillary phenomenon and is expanded to the test line and the control line.
  • nitrocellulose membrane filters generally have high whiteness, it is relatively easy to visually check the test line and control line, and they are used in many inspection kits.
  • nitrocellulose membrane filters tends to vary widely due to non-uniform pore size and non-uniform thickness depending on the production date, production location, production lot, and the like. If such a variation in quality is large, the flow velocity of the flowing liquid tends to be uneven due to the capillary phenomenon, which may adversely affect the inspection result.
  • nitrocellulose membrane filters generally do not have good storage stability. Therefore, a test strip that replaces the nitrocellulose membrane filter, which has high whiteness and storage stability, is desired.
  • An object of the present invention is to provide an aluminum member having high whiteness and water suction performance.
  • the aluminum member according to the first aspect of the present invention includes a porous body including a skeleton formed by aggregating a plurality of aluminum particles and a plurality of voids surrounded by the skeleton.
  • the skeleton contains an outer shell containing aluminum oxide, the surface of the skeleton is formed by the outer shell, and the outer shell has at least one of a plurality of recesses and a plurality of protrusions on the surface.
  • the average particle size of the plurality of aluminum particles is 0.1 ⁇ m to 20 ⁇ m, and the porosity of the porous body is 85% by volume or more.
  • the average spacing between the concave portions included in the plurality of concave portions, or the average spacing between the convex portions included in the plurality of convex portions is 100 nm to 600 nm.
  • the immunochromatographic test strip according to the second aspect of the present invention includes an aluminum member.
  • the method for manufacturing an aluminum member according to the third aspect of the present invention includes a sintering step of sintering a plurality of aluminum metal particles to obtain a sintered body.
  • the above method includes an outer shell forming step of anodizing the sintered body to form an outer shell containing aluminum oxide on the surface of each aluminum metal particle contained in the plurality of aluminum metal particles.
  • the above method includes a removing step of removing a part of the surface of the outer shell. In the above method, the outer shell forming step and the removing step are alternately repeated.
  • Each aluminum metal particle contains at least one of pure aluminum and an aluminum alloy.
  • the average particle size of the plurality of aluminum metal particles is 0.1 to 20 ⁇ m, and the filling rate of the sintered body is 10% by volume to 40% by volume.
  • FIG. 1 is a schematic cross-sectional view showing an enlarged structure of a part of the porous body according to the present embodiment.
  • FIG. 2 is a schematic cross-sectional view showing an enlarged structure of a portion surrounded by the frame of FIG.
  • FIG. 3 is a schematic cross-sectional view showing another example of the porous body.
  • FIG. 4 is a schematic cross-sectional view showing another example of the porous body.
  • FIG. 5 is a schematic cross-sectional view showing an enlarged structure of FIG.
  • FIG. 6 is a cross-sectional view showing an example of the aluminum member according to the present embodiment.
  • FIG. 7 is a perspective view showing an example of an inspection kit using the aluminum member according to the present embodiment.
  • FIG. 1 is a schematic cross-sectional view showing an enlarged structure of a part of the porous body according to the present embodiment.
  • FIG. 2 is a schematic cross-sectional view showing an enlarged structure of a portion surrounded by the frame of FIG.
  • FIG. 3
  • FIG. 8 is a photograph of the surface of the aluminum member according to the first embodiment observed with a scanning microscope.
  • FIG. 9 is a photograph of the surface of the aluminum member according to the first embodiment observed with a scanning microscope.
  • FIG. 10 is a photograph of a cross section of the aluminum member according to the first embodiment observed with a scanning microscope.
  • FIG. 11 is a photograph of the surface of the aluminum member according to Comparative Example 13 observed with a scanning microscope.
  • FIG. 12 is a photograph of the surface of the aluminum member according to Comparative Example 13 observed with a scanning microscope.
  • the aluminum member according to the present embodiment the test strip for immunochromatography, and the method for manufacturing the aluminum member will be described in detail with reference to the drawings.
  • the present invention is not limited to the following embodiments.
  • some or all of the components in the embodiment can be combined as appropriate.
  • the dimensional ratios in the drawings are exaggerated for convenience of explanation and may differ from the actual ratios.
  • Aluminum member In this embodiment, it was examined whether an aluminum member having a porous structure could be used as an alternative to the nitrocellulose membrane filter. However, it is usually considered that aluminum members have difficulty in exhibiting capillarity to the extent that they can be applied to immunochromatography. Further, the aluminum member is usually gray, and it is difficult to confirm the color development of the test line and the control line.
  • the aluminum member according to the present embodiment described in detail below has a high whiteness and a high water suction performance.
  • Such an aluminum member is expected to be useful not only as a substitute for a nitrocellulose membrane filter but also in various applications.
  • FIG. 1 is a schematic cross-sectional view showing an enlarged structure of a part of the porous body 40 according to the present embodiment.
  • 2 to 4 are schematic cross-sectional views showing an enlarged structure of a portion surrounded by the frame of FIG. 1.
  • FIG. 5 is a schematic cross-sectional view showing an enlarged structure of FIG.
  • the aluminum member 100 according to the present embodiment includes a porous body 40.
  • the porous body 40 contains a plurality of aluminum particles 15.
  • the porous body 40 contains a plurality of voids 16. More specifically, as shown in FIGS. 2 to 5, the porous body 40 includes a skeleton 11 formed by aggregating a plurality of aluminum particles 15 and a void 16 surrounded by the skeleton 11.
  • the skeleton 11 includes an outer shell 12, and the surface of the skeleton 11 is formed by the outer shell 12.
  • Each aluminum particle 15 included in the plurality of aluminum particles 15 may be a hollow particle including an outer shell 12 and a cavity 17 surrounded by the outer shell 12.
  • a plurality of aluminum particles 15 are connected via the outer shell 12 to form a skeleton 11 having a three-dimensional network structure, and the outer shell 12 is arranged on the outer surface side of the aluminum member 100.
  • the outer shell 12 has at least one of a plurality of concave portions 13 (first concave portions) and a plurality of convex portions 14 (first convex portions) on its surface.
  • the aluminum member 100 has a rough surface structure on its surface.
  • the rough surface structure refers to a surface structure in which the surface is rougher than a smooth surface by having a plurality of irregularities on the surface.
  • the rough surface structure means that at least one of the concave portion 13 and the convex portion 14 is dispersedly arranged on the surface of the aluminum member 100. It is preferable that no needle-shaped or plate-shaped uneven structure is arranged on the rough surface structure on the surface of the aluminum member 100.
  • the rough surface structure of the aluminum member 100 can be represented by the primary rough surface structure 10, the secondary rough surface structure 20, and the tertiary rough surface structure 30 in descending order of the scale of the surface roughness.
  • the scale of the surface roughness of the secondary rough surface structure 20 is larger than the scale of the surface roughness of the primary rough surface structure 10
  • the scale of the surface roughness of the tertiary rough surface structure 30 is the scale of the surface roughness of the secondary rough surface structure 20. Greater than the degree scale.
  • the aluminum member 100 has a primary rough surface structure 10, a secondary rough surface structure 20, and a tertiary rough surface structure 30 to increase the whiteness.
  • the primary rough surface structure 10 is composed of the outer surface of the outer shell 12 of each aluminum particle 15.
  • the primary rough surface structure 10 is a fine rough surface structure formed by at least one of the outer shell 12, the plurality of concave portions 13 existing on the surface of the outer shell 12, and the plurality of convex portions 14.
  • the primary rough surface structure 10 is a structure having a surface roughness scale on the order of several nm to several hundred nm.
  • the secondary rough surface structure 20 is composed of the outer surfaces of a plurality of aluminum particles 15.
  • the secondary rough surface structure 20 is a rough surface structure composed of a skeleton 11 and a plurality of voids 16 in the porous body 40. That is, the secondary rough surface structure 20 is formed by a convex portion 21 (second convex portion, protruding portion) and a concave portion 22 (second concave portion, recessed portion).
  • the convex portion 21 is formed by a plurality of aluminum particles 15 or a skeleton 11, and protrudes toward the outside of the porous body 40.
  • the recess 22 is formed by a plurality of aluminum particles 15 or a skeleton 11, and is recessed toward the inside of the porous body 40.
  • the void 16 is formed by the internal space of the porous body 40 surrounded by the plurality of aluminum particles 15 forming the recess 22 or the skeleton 11.
  • the secondary rough surface structure 20 is formed on the surface of the aluminum member 100 by the plurality of aluminum particles 15 themselves.
  • the secondary rough surface structure 20 is a structure having a surface roughness scale on the order of several hundred nm to several tens of ⁇ m.
  • the convex portion 21 may be referred to as a protruding portion
  • the concave portion 22 may be referred to as an indented portion.
  • the porous body 40 is a porous body having a void 16 communicating with the outside inside.
  • the void 16 is surrounded by the outer shell 12. That is, the concave portion 13 and the convex portion 14 of the primary rough surface structure 10 are formed in the outer shell 12 on the surface of the porous body 40, whereas the void 16 of the secondary rough surface structure 20 is the porous body 40. It is formed by being surrounded by the skeleton 11 inside or the outer shell 12 formed on the surface thereof.
  • the void 16 forming one cell structure surrounded by the outer shell 12 may communicate with the void 16 forming another cell structure.
  • the porous body 40 may have an open cell type structure. Further, the single void 16 or the plurality of voids 16 may or may not penetrate from one surface to the other surface of the porous body 40.
  • the tertiary rough surface structure 30 is composed of the outer surface of the porous body 40.
  • the tertiary rough surface structure 30 is a coarse rough surface structure formed by gathering a plurality of irregularities due to the primary rough surface structure 10 and the secondary rough surface structure 20.
  • the tertiary rough surface structure 30 is an aggregate composed of an aggregate of the primary rough surface structure 10 and the secondary rough surface structure 20 on the surface of the aluminum member 100.
  • the tertiary rough surface structure 30 is formed by developing an uneven structure composed of an aggregate of the primary rough surface structure 10 and the secondary rough surface structure 20 by the outer shell forming step and the removing step.
  • the tertiary rough surface structure 30 is a structure having a surface roughness scale on the order of several tens of ⁇ m to several hundreds of ⁇ m.
  • a concavo-convex structure is formed on the surface of the aluminum member 100 by the tertiary rough surface structure 30 composed of an aggregate of the primary rough surface structure 10 and the secondary rough surface structure 20.
  • the tertiary rough surface structure 30 has a convex portion 31 (third convex portion and a mountain portion) and a concave portion 32 (third concave portion) due to an aggregate of the primary rough surface structure 10 and the secondary rough surface structure 20. , Tanibe) and are formed.
  • the convex portion 31 rises like a mountain with respect to the thickness direction of the surface of the aluminum member 100
  • the concave portion 32 falls like a valley with respect to the thickness direction of the surface of the aluminum member 100.
  • the convex portions 31 and the concave portions 32 appear at repeated intervals, so that the tertiary rough surface structure 30 has a periodic uneven surface structure having a larger scale than the primary rough surface structure 10 and the secondary rough surface structure 20. have.
  • the convex portion 31 may be referred to as a mountain portion
  • the concave portion 32 may be referred to as a valley portion.
  • the period of the tertiary rough surface structure 30 is preferably 10 ⁇ m to 500 ⁇ m.
  • the period of the tertiary rough surface structure 30 is that in the plane direction of the aluminum member 100, the convex portions 31 appearing periodically adjacent to each other across the concave portion 32, or the concave portions appearing periodically adjacent to each other across the convex portion 31. It refers to the interval between 32.
  • the period of the tertiary rough surface structure 30 is more preferably 30 ⁇ m or more. Further, the period of the tertiary rough surface structure 30 is more preferably 200 ⁇ m or less.
  • the period of the tertiary rough surface structure 30 can be measured by observing the cross section of the aluminum member 100 with an optical microscope or the like.
  • the aluminum member 100 reduces the glossiness of the surface and improves the matte feeling. As a result, the gloss generated on the surface of the aluminum member 100 is suppressed, and the visibility of information such as colors, patterns, figures, symbols, and characters presented on the aluminum member 100 is improved. Such improvement in visibility is effective when, for example, the aluminum member 100 is used as a test sheet or a test strip for chromatography, and the test result generated on the aluminum member 100 is visually or optically confirmed.
  • the aluminum member 100 includes a porous body 40.
  • the porous body 40 is obtained by sintering an aluminum powder containing a plurality of aluminum particles 15 or a green powder obtained by compacting the aluminum powder to obtain a sintered body, and the sintered body is described later.
  • the shell forming step and the removing step are performed.
  • the porous body 40 includes a skeleton formed by aggregating a plurality of aluminum particles 15. Further, the porous body 40 includes a void 16 surrounded by a skeleton. Further, the porous body 40 includes a plurality of cavities 17 existing inside the skeleton 11.
  • the aluminum particles 15 may have an internal cavity 17 separated by an outer shell 12 and a through hole (gap) 18 communicating with the outside.
  • the cavity 17 can communicate with the outside of the aluminum particles 15 or the skeleton 11 through the through holes 18 penetrating the outer shell 12 in the thickness direction.
  • the porous body 40 When the porous body 40 is impregnated with the liquid, the liquid can flow into or out of the cavity 17 from the through hole 18 of the outer shell 12. Further, each of the cavities 17 contained in the adjacent aluminum particles 15 communicates with the plurality of cavities 17. Therefore, when the porous body 40 is impregnated with the liquid, the liquid can flow inside the skeleton 11 by passing through the cavity 17 through the through hole 18.
  • labels such as colored particles or colloidal gold particles are usually used.
  • the porous body 40 can suck up a solution in which a label is dispersed by a capillary phenomenon. The mechanism at this time is not clear, but it is considered that the solution in which the label is dispersed permeates the spaces of the voids 16 and 17. Further, although the solution is mainly sucked up by flowing through the void 16, it is presumed that the flow of the solution through the cavity 17 and the through hole 18 also contributes to the sucking up.
  • the average particle size of the plurality of aluminum particles 15 is 0.1 ⁇ m to 20 ⁇ m.
  • the average particle size is preferably 1 ⁇ m or more, more preferably 3 ⁇ m or more, and even more preferably 5 ⁇ m or more.
  • the average particle size is preferably 18 ⁇ m or less, more preferably 15 ⁇ m or less, and even more preferably 10 ⁇ m or less.
  • the average particle size of the plurality of aluminum particles 15 can be measured by observing the cross section of the porous body 40 with a scanning electron microscope. For example, the sintered aluminum particles are partially melted or connected, but the portion having a substantially circular shape can be regarded as approximately circular. Therefore, in the above cross-sectional observation, the maximum diameter (major axis) of each of the aluminum particles having a substantially circular shape is set as the particle size, the particle size of any 50 aluminum particles is measured, and the arithmetic average of these is calculated after sintering.
  • the average particle size of the plurality of aluminum metal particles before sintering is a D50 value obtained by measuring the particle size distribution on a volume basis by a laser diffraction method.
  • the average particle size of the sintered aluminum particles 15 observed by the scanning electron microscope and the baking measured by the laser diffraction method. It is almost the same as the average particle size of the aluminum metal particles before firing.
  • each aluminum particle 15 is not particularly limited, and may be spherical, polygonal, indefinite, scaly, fibrous, or the like. Among these, it is preferable that the shape of each aluminum particle 15 contained in the plurality of aluminum particles is spherical. When the shape of each aluminum particle 15 is spherical, the sizes of the plurality of voids 16 become uniform. For example, in immunochromatography, as will be described later, labels such as colored particles or colloidal gold particles are usually used, but if the sizes of the voids 16 are uniform, such labels will appear in the voids 16. It is not captured and can flow smoothly in the porous body 40.
  • the sphere referred to here may be not only a true sphere but also one having some irregularities on the surface. Further, the spherical shape referred to here may include not only one having an aspect ratio of 1 but also one having an aspect ratio of 5 or less, 3 or less, or 2 or less.
  • the aspect ratio is the ratio of the major axis to the minor axis of the aluminum particles 15, and is the average value of the plurality of aluminum particles 15.
  • the outer shell 12 forms the surface of the skeleton 11.
  • the outer shell 12 contains aluminum oxide.
  • the outer shell 12 is preferably an anodized film, and the anodized film is preferably a barrier type anodized film.
  • the outer shell 12 may contain aluminum hydroxide.
  • the outer shell 12 may have a hydrated film containing aluminum hydroxide.
  • the outer shell 12 may have an anodized film and a hydrated film laminated in this order from the cavity 17 side, but a hydrated film is formed on a part of the surface side of the anodized film. Is preferably provided.
  • the anodized film and the hydrated film may be distributed in an island shape, but the anodized film is distributed in a sea shape and the hydrated film is distributed in an island shape. It is preferable to have.
  • the ratio of the hydrated film to the entire outer surface of the outer shell 12 is preferably 5% or more and 50% or less, more preferably 10% or more and 40% or less, and 15% or more and 30%. The following is more preferable.
  • the outer shell 12 contains aluminum hydroxide and aluminum hydroxide is present on a part of the outermost surface of the porous body 40, it is preferable that the aluminum hydroxide forms the convex portion 14.
  • the porous body 40 according to the present embodiment does not have a hydrated film formed on the entire outermost surface. Since the porous body 40 does not contain a hydrated film on the entire outermost surface, diffuse reflection becomes dominant and the whiteness of the aluminum member 100 can be further improved.
  • Aluminum hydroxide is represented by the general formula Al (OH) 3.
  • the aluminum member 100 When the outermost surface of the outer shell 12 is covered with a needle-shaped or plate-shaped hydrated film, the aluminum member 100 may be observed as black or gray. This is because such a hydrated film has a sharp tip shape near the surface, and although this tip portion contributes to the diffuse reflection of incident light, the portion capable of diffuse reflection is the tip portion. It is considered that the small area has an effect. Further, such a film has an internal shape in which the space between adjacent needle-shaped or plate-shaped hydrated films gradually narrows from the tip portion to the root portion. Therefore, the incident light that has entered the inside is absorbed by the hydrated film as it is repeatedly reflected, and it is difficult for the light to be emitted to the outside, which also affects that the aluminum member 100 is observed in black or gray. it is conceivable that.
  • the outer shell 12 made of an anodized film is provided on the surface of the porous body 40, and the recesses 13 and the voids 16 are present on the outermost surface of the outer shell 12.
  • aluminum hydroxide does not cover the entire outermost surface of the porous body 40 to form a hydrated film, but exists in a part of the outermost surface of the porous body 40 in the form of granules or lumps to form the convex portion 14.
  • the whiteness can be improved by the convex portion 14.
  • the whiteness can be improved by the convex portion 14 and the concave portion 13 exposed on the outermost surface of the porous body 40 without being covered with the hydrated film. Further, when aluminum hydroxide covers the entire outermost surface of the porous body 40 to form a hydrated film and is present on the outermost surface of the porous body 40 in the form of particles or lumps to form the convex portion 14. , The whiteness can be improved by the convex portion 14.
  • the outer shell 12 preferably has a thickness of 5 nm to 1000 nm. By setting the thickness of the outer shell 12 in such a range, it becomes easy to secure a sufficient thickness for diffuse-reflecting the light incident on the porous body 40, and the aluminum member 100 having a better whiteness can be obtained. Can be provided. Further, it is possible to provide an aluminum member 100 having sufficiently high corrosion resistance.
  • the thickness of the outer shell 12 is more preferably 20 nm or more, further preferably 30 nm or more, and particularly preferably 50 nm or more.
  • the thickness of the outer shell 12 is more preferably 800 nm or less, further preferably 500 nm or less, and particularly preferably 300 nm or less.
  • the thickness of the outer shell 12 can be measured, for example, by observing the cross section of the outer shell 12 with a scanning electron microscope or the like.
  • the thickness of the outer shell 12 means the thickness which does not include the concave portion 13 and the convex portion 14.
  • the outer shell 12 has at least one of a plurality of concave portions 13 and a plurality of convex portions 14 on the surface of the outer shell 12.
  • the outer shell 12 may have a plurality of recesses 13 on the surface of the outer shell 12.
  • the outer shell 12 may have a plurality of convex portions 14 on the surface of the outer shell 12.
  • the outer shell 12 may have a plurality of concave portions 13 and a plurality of convex portions 14 on the surface of the outer shell 12. That is, the outer shell 12 may have either the concave portion 13 or the convex portion 14, or may have both the concave portion 13 and the convex portion 14.
  • the presence or absence of the concave portion 13 or the convex portion 14 can be determined by observing the surface of the outer shell 12 with a scanning electron microscope or the like.
  • the concave portion 13 and the convex portion 14 contribute to the whiteness of the aluminum member 100.
  • the reason why the whiteness of the aluminum member 100 is improved by forming at least one of the concave portion 13 and the convex portion 14 on the surface of the outer shell 12 is not necessarily clear, but it is presumed as follows. First, when light is incident on the aluminum member, the incident light is reflected on the surface of the aluminum member. At this time, if the surface of the aluminum member is smooth, it exhibits a mirror-like luster. Here, when the surface of the aluminum member has fine irregularities, diffuse reflection of incident light occurs due to the irregularities, but usually there are no irregularities that can be visually recognized as white.
  • the diffuse reflection on the surface of the outer shell 12 can be increased by the concave portion 13 and the convex portion 14. That is, when the outer shell 12 has the recess 13, the area where the incident light can be diffusely reflected is increased by the recess 13, so that the aluminum member 100 is observed to be white. Similarly, when the outer shell 12 has the convex portion 14, the area where the incident light can be diffusely reflected is increased by the convex portion 14, so that the aluminum member 100 is observed to show white.
  • the recess 13 is preferably formed by being recessed from the exposed surface of the outer shell 12 toward the cavity 17. It is preferable that the bottom of the recess 13 does not penetrate to the cavity 17, and an outer shell 12 is formed between the recess 13 and the cavity 17.
  • the shape of the recess 13 is not particularly limited, but is preferably substantially U-shaped or substantially V-shaped in cross-sectional view in the thickness direction of the outer shell 12.
  • the outer shell forming step produces an outer shell 12 made of an anodized film on the surface of the aluminum metal particles.
  • the recess 13 is formed in this anodized film.
  • the convex portion 14 is preferably formed so as to project outward from the exposed surface of the outer shell 12.
  • the shape of the convex portion 14 is not particularly limited, but is preferably granular or lumpy.
  • each recess 13 included in the plurality of recesses 13 is preferably 10 nm to 200 nm. Further, the diameter of each convex portion 14 included in the plurality of convex portions 14 is preferably 10 nm to 200 nm. By setting the diameters of the concave portion 13 and the convex portion 14 within such a range, the light incident on the porous body 40 can be easily diffusely reflected by the concave portion 13 and the convex portion 14, and the aluminum member 100 having a better whiteness can be obtained. Can be provided.
  • the diameter of each recess 13 is more preferably 20 nm or more, and further preferably 50 nm or more.
  • each recess 13 is more preferably 150 nm or less, and further preferably 110 nm or less.
  • the diameter of each convex portion 14 is more preferably 20 nm or more, and further preferably 50 nm or more. Further, the diameter of each convex portion 14 is more preferably 150 nm or less, and further preferably 110 nm or less.
  • the diameter of the recess 13 can be obtained by observing the surface of the outer shell 12 with a scanning electron microscope or the like and measuring the diameter of the inlet portion of the recess 13.
  • the diameter of the convex portion 14 can be obtained by observing the surface of the outer shell 12 with a scanning electron microscope or the like and measuring the diameter of the portion having the largest diameter of the convex portion 14.
  • the position of the recess 13 is determined by the deepest position of the recess 13 (peak position on the bottom side).
  • the distance between the adjacent recesses 13 can be determined by the distance between the peak positions on the bottom side of each recess 13.
  • the recess 13 is regarded as an independent recess 13.
  • a plurality of recesses 13 are gathered at an interval of less than 50 nm and form a group existing at a distance of 50 nm or more from the surrounding recesses 13 not included in the group.
  • This group is considered as one recess 13. Then, the diameter of the entire group is measured as the diameter of the recess 13.
  • the plurality of recesses 13 are independent of each other. It is regarded as the recess 13.
  • the regions belonging to the respective recesses 13 can be defined by performing the Voronoi division with the peak position on the bottom side of the plurality of recesses 13 as the base point for the recesses sharing the peripheral edge portion. ..
  • the position of the convex portion 14 is determined by the highest position (peak position on the top side) of the convex portion 14.
  • the distance between the adjacent convex portions 14 can be determined by the distance between the peak positions on the top side of the respective convex portions 14.
  • a group in which a plurality of convex portions 14 are gathered at an interval of less than 50 nm, and a group existing at a distance of 50 nm or more from the surrounding convex portions 14 not included in the group is formed. If so, this population is considered as one ridge 14. Then, the diameter of the entire group is measured as the diameter of the convex portion 14.
  • the plurality of convex portions 14 are separate. Is considered to be an independent convex portion 14.
  • the regions belonging to the respective convex portions 14 are defined by performing the Voronoi division with the peak position on the top side of the plurality of convex portions 14 as the base point for the overhang sharing the peripheral portion. Can be done.
  • each recess 13 included in the plurality of recesses 13 is preferably 10 nm to 100 nm in cross-sectional view in the thickness direction of the outer shell 12.
  • the depth of each recess 13 is more preferably 20 nm or more, and further preferably 30 nm or more. Further, the depth of each recess 13 is more preferably 80 nm or less, and further preferably 70 nm or less.
  • the depth of the recess 13 can be obtained by observing the cross section of the outer shell 12 with a scanning electron microscope or the like and calculating the average value obtained by measuring the distance from the inlet portion to the bottom of the recess 13.
  • each convex portion 14 included in the plurality of convex portions 14 is preferably 10 nm to 100 nm in cross-sectional view in the thickness direction of the outer shell 12.
  • the height of each convex portion 14 is more preferably 20 nm or more, and further preferably 30 nm or more. Further, the height of each convex portion 14 is more preferably 80 nm or less, and further preferably 70 nm or less.
  • the cross section of the outer shell 12 is observed with a scanning electron microscope or the like, and the average value obtained by measuring the distance from the surface of the flat portion of the outer shell 12 to the top of the convex portion 14 is calculated. Can be obtained by
  • the depth of the concave portion 13 and the height of the convex portion 14 exceed the lower limit of the above range, the area where the incident light by the concave portion 13 and the convex portion 14 can be diffusely reflected increases, and the diffuse reflection tends to increase. Further, when the depth of the concave portion 13 and the height of the convex portion 14 are less than the upper limit of the above range, the reduction of diffuse reflection caused by the concave portion 13 and the convex portion 14 becoming, for example, a needle-shaped or plate-shaped concave-convex structure. Can be suppressed.
  • the decrease in the diffuse reflection is due to the decrease in the area where the incident light can be diffusely reflected and the absorption of the incident light due to the needle-shaped or plate-shaped uneven structure.
  • the aluminum member 100 tends to be observed to show white color.
  • the density of the concave portion 13 and the convex portion 14 in the outer shell 12 is preferably 3 pieces / ⁇ m 2 to 500 pieces / ⁇ m 2.
  • the density of the concave portion 13 and the convex portion 14 is more preferably 5 pieces / ⁇ m 2 or more, and further preferably 10 pieces / ⁇ m 2 or more.
  • the density of the concave portion 13 and the convex portion 14 is more preferably 200 pieces / ⁇ m 2 or less, and further preferably 100 pieces / ⁇ m 2 or less.
  • the density of the concave portion 13 and the convex portion 14 can be obtained by counting the total number of the concave portion 13 and the convex portion 14 per unit area on the surface of the outer shell 12 by a scanning electron microscope or the like.
  • the area ratio of the concave portion 13 and the convex portion 14 in the outer shell 12 is preferably 5% to 80%.
  • the area ratio of the concave portion 13 and the convex portion 14 is more preferably 20% or more, and further preferably 30% or more.
  • the area ratio of the concave portion 13 and the convex portion 14 is more preferably 70% or less, and further preferably 60% or less.
  • the area ratio of the concave portion 13 and the convex portion 14 represents the ratio of the area occupied by the concave portion 13 and the convex portion 14 to the surface area of the outer shell 12 on the surface of the porous body 40 as a percentage.
  • the area ratio of the concave portion 13 and the convex portion 14 can be obtained by calculating the total area occupied by the concave portion 13 and the convex portion 14 per unit area on the surface of the outer shell 12 by a scanning electron microscope or the like.
  • the average interval indicates how much the concave portions 13 or the convex portions 14 that are close to each other on the surface of the outer shell 12 are present. In other words, it indicates whether the concave portion 13 or the convex portion 14 exists densely or sparsely.
  • the average spacing between the recesses 13 included in the plurality of recesses 13 or the average spacing between the convex portions 14 included in the plurality of convex portions 14 is referred to as "the average spacing of the concave portions or the convex portions", or simply “average”. Also called "interval".
  • the average spacing of the recesses or protrusions represents the average spacing between the recesses 13 included in the plurality of recesses 13.
  • the average spacing between the concave portions or the convex portions represents the average spacing between the convex portions 14 included in the plurality of convex portions 14.
  • the adjacent concave portions 13 and the convex portions 14 are treated as a group, and the convex portions 14 are used as a reference.
  • the average spacing between the concave portions or the convex portions is such that the convex portions included in the plurality of concave portions 13 and the plurality of convex portions 14. It represents the average interval between 14.
  • the average interval is usually 100 nm to 600 nm.
  • the average interval is preferably 150 nm or more, more preferably 170 nm or more, and even more preferably 200 nm or more.
  • the average interval is preferably 400 nm or less, more preferably 350 nm or less, and even more preferably 300 nm or less.
  • the concave portions 13 and the convex portions 14 are appropriately gathered on the surface of the outer shell 12, and the light incident on the porous body 40 is collected by the concave portions 13 and the convex portions 14. It becomes easy to diffuse and reflect efficiently. As a result, it is possible to provide the aluminum member 100 having a better whiteness.
  • the average distance can be calculated by observing the surface of the outer shell 12 in which the concave portion 13 or the convex portion 14 is present and measuring the distance between the concave portion 13 or the convex portion 14 existing on the surface. Specifically, first, the surface of the outer shell 12 is observed with a scanning electron microscope or the like to obtain an image of the surface of the outer shell 12. Next, a line segment (reference line) having a length of about the diameter of the aluminum particles 15 is randomly drawn on the aluminum particles 15 included in this image. Subsequently, the number of intersections between the concave portion 13 or the convex portion 14 contained in the aluminum particles 15 and the reference line is counted.
  • the number of intersections between the convex portion 14 and the reference line is counted. Further, as described above, a group in which a plurality of concave portions 13 or a plurality of convex portions 14 are gathered at an interval of less than 50 nm, and the surrounding concave portions 13 or convex portions 14 not included in the group are 50 nm or more. When forming a group that exists at intervals of, the number of intersections with the reference line is counted with this group as one concave portion 13 or convex portion 14.
  • the average distance between the concave portions or the convex portions in the aluminum particles 15 on which the reference line is drawn is calculated.
  • the average spacing of the concave or convex portions is obtained by calculating the average spacing of at least three places for the different aluminum particles 15 and averaging the obtained numerical values.
  • the average pore diameter of the plurality of voids 16 and the plurality of cavities 17 contained in the porous body 40 is preferably 2.5 ⁇ m to 20 ⁇ m.
  • the average pore diameter is about 10 nm to 50 nm, and some labels have a larger particle size.
  • the aluminum member 100 is used, for example, in a test strip for immunochromatography, by setting the average pore diameter to 2.5 ⁇ m or more, such a label is not captured in the void 16 and the inside of the porous body 40 is not captured. It can flow smoothly.
  • the average pore diameter is preferably 3 ⁇ m or more, and more preferably 4 ⁇ m or more.
  • the average pore diameter is preferably 15 ⁇ m or less, and more preferably 10 ⁇ m or less.
  • the average pore diameter can be measured by the mercury intrusion method. In the present specification, the average pore diameter shall mean a volume-based median diameter.
  • k is a constant, and specifically, k is preferably 200 to 2000. With such a gap 16, it becomes easy to secure an appropriate diameter for sucking up water due to the capillary phenomenon, and the water sucking performance of the aluminum member 100 can be improved. More preferably, k is 500 or more. Further, k is more preferably 1500 or less.
  • the diameter of the concave portion 13 or the convex portion 14 is within the above-mentioned predetermined range and is smaller than the above-mentioned average pore diameter.
  • the diameter of each recess 13 is preferably 10 nm to 200 nm and smaller than the average pore diameter.
  • the diameter of each convex portion 14 is preferably 10 nm to 200 nm, and is preferably smaller than the average pore diameter.
  • the porosity of the porous body 40 is 85% by volume or more.
  • the porosity of the porous body 40 may be 85% by volume to 99% by volume.
  • the porosity is preferably 88% by volume or more, more preferably 90% by volume or more, and further preferably 92% by volume or more.
  • the porosity may be 95% by volume or less, or 93% by volume or less.
  • the porosity is the ratio of the volumes of all the voids 16 and the cavities 17 in the porous body 40 to the total volume of the porous body 40.
  • the porosity of the porous body 40 can be determined by the mercury intrusion method.
  • the thickness of the porous body 40 is preferably 30 ⁇ m to 10 cm. By setting the thickness of the porous body 40 to 30 ⁇ m or more, it becomes easy to secure a sufficient thickness for sucking up water due to the capillary phenomenon, and to provide an aluminum member 100 having better whiteness and water sucking performance. Can be done. By setting the thickness of the porous body 40 to 10 cm or less, it is possible to prevent the porous body 40 from cracking even when it is wound with a roll for transportation or the like.
  • the thickness of the porous body 40 is preferably 40 ⁇ m or more, and more preferably 50 ⁇ m or more.
  • the thickness of the porous body 40 is more preferably 1000 ⁇ m or less, further preferably 200 ⁇ m or less, and particularly preferably 150 ⁇ m or less.
  • the porous body 40 may be composed of a single porous layer, but may include a plurality of porous layers.
  • the porous body 40 may include, for example, a first porous layer and a second porous layer arranged on the surface of the first porous layer.
  • the first porous layer and the second porous layer differ in any one of the average particle diameter, aspect ratio, or constituent materials of the plurality of aluminum particles 15, the porosity of the porous body 40, the average pore diameter, and the like. May be.
  • the average particle size of each aluminum particle 15 contained in the first porous layer may be larger than the average particle size of each aluminum particle 15 contained in the second porous layer.
  • the thicknesses of the first porous layer and the second porous layer may be the same or different.
  • the aluminum member 100 may further include a substrate 50.
  • the substrate 50 can support the porous body 40 and can improve the rigidity of the aluminum member 100.
  • the substrate 50 may have a layered shape.
  • the porous body 40 may be provided on at least one surface side of the substrate 50. Specifically, the porous body 40 may be provided only on one surface side of the substrate 50, or may be provided on both surface sides of the substrate 50. The porous body 40 is preferably arranged on the outermost surface of the aluminum member 100.
  • the thickness of the substrate 50 is more than 0 ⁇ m.
  • the thickness of the substrate 50 may be, for example, 1 mm or less, 100 ⁇ m or less, 10 ⁇ m or less, or 1 ⁇ m or less, depending on the application.
  • the substrate 50 can use the same material as the aluminum particles 15.
  • the substrate 50 may contain at least one of aluminum and an aluminum alloy.
  • the material constituting the substrate 50 may be the same as or different from the material constituting the aluminum particles 15.
  • the thickness of the aluminum member 100 depends on the application, but may be, for example, 50 ⁇ m or more, 100 ⁇ m or more, or 150 ⁇ m or more.
  • the thickness of the aluminum member 100 may be 300 ⁇ m or less, 250 ⁇ m or less, or 200 ⁇ m or less.
  • the arithmetic mean roughness Sa of the aluminum member 100 is preferably 0.1 ⁇ m to 30 ⁇ m. By setting the arithmetic mean roughness Sa in such a range, the L * value tends to increase, and it becomes easy to provide the aluminum member 100 having a better whiteness.
  • the arithmetic mean roughness Sa is more preferably 1 ⁇ m or more, and further preferably 3 ⁇ m or more.
  • the arithmetic mean roughness Sa is more preferably 20 ⁇ m or less, and further preferably 10 ⁇ m or less.
  • the arithmetic mean roughness Sa can be obtained by measuring the surface of the aluminum member 100 on the porous body 40 side according to ISO25178. In the present specification, the arithmetic mean roughness Sa of the aluminum member 100 mainly reflects the roughness due to the secondary rough surface structure 20.
  • L * a * b * L * values in the color system is, for example, may be 75 or more.
  • the L * value is preferably 80 or more, more preferably 85 or more, further preferably 88 or more, particularly preferably 90 or more, and 95 or more. Is most preferable.
  • the L * value in the L * a * b * color system can be obtained according to JIS Z8722: 2009 (color measurement method-reflection and transmission object color). Specifically, the L * value can be measured using a color difference meter or the like, and can be measured under conditions such as a diffuse illumination vertical light receiving method (D / 0), a viewing angle of 2 °, and a C light source. ..
  • the time required to suck up water to a height of 4 cm due to the capillary phenomenon is 200 seconds or less.
  • the time may be 40 seconds or more, or 70 seconds or more. Further, the time may be 140 seconds or less, or 90 seconds or less.
  • the time is, for example, the time required to immerse the aluminum member 100 in pure water so that the plane direction of the aluminum member 100 is perpendicular to the liquid surface, and to suck up water to a height of 4 cm by capillarity. Can be obtained by doing.
  • the pure water is pure water having a specific resistance of 10 km ⁇ m measured at 30 ° C.
  • the aluminum member 100 has a water suction height of 3 cm or more, more preferably 4 cm or more, and even more preferably 5 cm or more due to the capillary phenomenon. By doing so, it is possible to provide an aluminum member 100 suitable for, for example, chromatography.
  • the suction height is, for example, the height at which water is sucked up by the capillary phenomenon after the aluminum member 100 is immersed in pure water and left for 10 minutes so that the plane direction of the aluminum member 100 is perpendicular to the liquid surface. It can be obtained by measuring the height.
  • the pure water is pure water having a specific resistance of 10 km ⁇ m measured at 30 ° C.
  • the aluminum member 100 does not break even if it is bent 100 times or more in a bending test according to the MIT type bending test method.
  • the aluminum member 100 can be easily stored and transported in a roll shape.
  • the MIT type bending test method is specified by EIAJ RC-2364A, and the MIT type bending test device uses the device specified by JIS P8115 (paper and paperboard-folding strength test method-MIT testing machine method). can do.
  • the aluminum member 100 includes a porous body 40 including a skeleton 11 formed by aggregating a plurality of aluminum particles 15 and a plurality of voids 16 surrounded by the skeleton 11. ..
  • the skeleton 11 contains an outer shell 12 containing aluminum oxide, the surface of the skeleton 11 is formed by the outer shell 12, and the outer shell 12 has at least one of a plurality of recesses 13 and a plurality of protrusions 14 on the surface. doing.
  • the average particle size of the plurality of aluminum particles 15 is 0.1 ⁇ m to 20 ⁇ m, and the porosity of the porous body 40 is 85% by volume or more.
  • the average spacing between the recesses 13 included in the plurality of recesses 13 or the average spacing between the convex portions 14 included in the plurality of convex portions 14 is 100 nm to 600 nm.
  • the aluminum member 100 according to the present embodiment has high whiteness and water suction performance, but is not limited to applications in which any of these characteristics is required, and is used in applications in which either one of the characteristics is required. Can also be used.
  • Examples of useful uses of the aluminum member 100 according to the present embodiment include, for example, a gas or liquid separation membrane; a moisture absorbing material; a water absorbing material; adsorbing foreign substances such as pollen, particulate matter, bacteria, odorous components, and heavy metals.
  • Adsorption material Adsorption material; Wiping sheet; Test sheet for chemicals such as concentrated sulfuric acid, for urine examination and pH test; Test strip for chromatography such as thin layer chromatography; Material for sterilization and sterilization; Reflective material: Standard white plate Separators such as batteries and electric double layer capacitors; catalyst carriers; reaction fields for synthetic reactions and the like; heat insulating materials; and the like.
  • Examples of the separation membrane include a reverse osmosis membrane, an ion exchange membrane, and a gas separation membrane.
  • the adsorbent material include masks, filtration membranes, filters and the like.
  • the aluminum member 100 Since the aluminum member 100 has a high whiteness, it is preferable to use it as a test sheet, a test strip for chromatography, a reflective material, and a standard white plate. Further, since the aluminum member 100 is porous, it is preferably used as a separation membrane, a moisture absorbing material, a water absorbing material, an adsorption material, a test strip for chromatography, a separator, a catalyst carrier, a reaction field, and a heat insulating material.
  • the aluminum member 100 is more preferably used for chromatography and further preferably used for immunochromatography because of its high whiteness and water suction performance. Therefore, the immunochromatographic test strip according to the present embodiment includes an aluminum member 100.
  • the immunochromatographic test strip is also referred to as an immunochromatographic unfolding member, a lateral flow assay test strip, or a lateral flow assay unfolding member.
  • the aluminum member 100 is used for an in-vitro diagnostic drug such as a test kit using immunochromatography.
  • the test kit may also be referred to as a diagnostic kit.
  • the inspection kit 200 includes an aluminum member 100.
  • the inspection kit 200 includes an aluminum member 100, a sample supply unit 110, a determination unit 120, and an absorption unit 130.
  • the aluminum member 100 may be the test strip.
  • the sample supply unit 110 may contain, for example, a labeled antibody that specifically binds to a detection target such as influenza virus.
  • the sample collected from a living body or the like is supplied to the sample supply unit 110 and mixed with the labeled antibody to form a mixed solution.
  • the mixed liquid is expanded to the determination unit 120 due to the capillary phenomenon of the aluminum member 100, and the surplus sample is absorbed by the absorption unit 130.
  • the determination unit 120 has, for example, a test line and a control line.
  • an antibody that specifically binds to a detection target is immobilized on the test line.
  • the labeled antibody is fixed to the antibody on the test line via the detection target.
  • an antibody that specifically binds to a labeled antibody is immobilized on the control line.
  • the mixture containing the sample and the labeled antibody is expanded to the control line, the labeled antibody binds to the antibody immobilized on the control line.
  • the labeled antibody generally includes a label such as colored particles or colloidal gold particles, and an antibody that binds to the label to form a complex and specifically binds to the detection target. Therefore, when there is a portion where the concentration or density of the labeled antibody is high, this portion can be visually confirmed by the concentration of the labels. Therefore, the test kit 200 can be tested as positive when both the test line and the control line can be visually confirmed, and negative when only the control line can be visually confirmed. ..
  • the test kit 200 can be used, for example, for infectious disease tests; genetic analysis; pregnancy tests; livestock tests; allergen tests for foods, animals, plants, metals, house dust, and the like.
  • test target by the test kit 200 examples include amino acids, peptides, proteins, genes, sugars, lipids, cells, or complexes thereof. More specifically, peptides such as PCT (procalcitonin); proteins such as urinary albumin; hormones such as HCG (human chorionic gonadotropin) and LH (yellowing hormone); HBs antigen, rotavirus antigen, adenovirus antigen , RSV (Respiratory Syncytial virus) antigen, influenza virus antigen, norovirus antigen, mumpvirus antigen, cytomegalovirus antigen, simple herpesvirus antigen, varicella / herpes zoster virus antigen, SARS (severe acute respiratory syndrome) antigen, HBs antibody, HCV Antigens or antibodies of viral infections such as (hepatitis C virus) antibody, HIV antibody, EBV antibody, RSV antibody, ruin virus antibody, measles virus antibody, enterovirus antibody, dengue virus antibody, SARS antibody; pneumonia
  • the method for manufacturing the aluminum member 100 according to the present embodiment includes a sintering step, an outer shell forming step, and a removing step. Further, the method for manufacturing the aluminum member 100 may include a hydration treatment step, if necessary. Hereinafter, each step will be described in detail.
  • sintering process In the sintering step, a plurality of aluminum metal particles are sintered to obtain a sintered body. Each aluminum metal particle contains at least one of pure aluminum and an aluminum alloy.
  • the purity of pure aluminum may be 99.00% by mass or more, 99.50% by mass or more, 99.80% by mass or more, or 99.99% by mass or more. It may be 99.995 mass% or more.
  • Pure aluminum may contain elements other than aluminum (Al). Elements other than aluminum contained in pure aluminum are silicon (Si), iron (Fe), copper (Cu), manganese (Mn), magnesium (Mg), chromium (Cr), zinc (Zn), and titanium (Ti). , Vanadium (V), gallium (Ga), nickel (Ni), boron (B), zirconium (Zr) and the like may contain one or more of the elements.
  • the content of elements other than aluminum contained in pure aluminum may be less than 1% by mass, or less than 0.01% by mass, respectively.
  • Aluminum alloy contains aluminum and elements other than aluminum.
  • Elements other than aluminum contained in aluminum alloys are silicon (Si), iron (Fe), copper (Cu), manganese (Mn), magnesium (Mg), chromium (Cr), zinc (Zn), titanium (Ti).
  • Vanadium (V), gallium (Ga), nickel (Ni), boron (B), zirconium (Zr) and the like may contain one or more of the elements.
  • the total content of elements other than aluminum contained in the aluminum alloy may exceed 1% by mass.
  • the elements other than aluminum contained in the aluminum alloy may be 10% by mass or less in total, or 5% by mass or less in total.
  • the content of elements other than aluminum contained in the aluminum alloy may be 10% by mass or less, or 1% by mass or less, respectively.
  • at least one of pure aluminum and an aluminum alloy is also simply referred to as aluminum.
  • the average particle size of the plurality of aluminum metal particles is 0.1 to 20 ⁇ m.
  • the average particle size of the plurality of aluminum metal particles before sintering is a D50 value obtained by measuring the particle size distribution on a volume basis by a laser diffraction method.
  • the shape of the particles is not particularly limited, and may be spherical, polygonal, indefinite, scaly, fibrous, or the like.
  • a plurality of aluminum metal particles can be produced by a known method.
  • the plurality of aluminum metal particles can be produced by, for example, an atomizing method, a melt spinning method, a rotating disk method, a rotating electrode method, or another quenching solidification method.
  • the plurality of aluminum metal particles are preferably produced by an atomizing method, and more preferably produced by a gas atomizing method.
  • the plurality of aluminum metal particles are preferably produced by atomizing the molten metal.
  • the plurality of aluminum metal particles may be sintered after being arranged on at least one surface of the substrate.
  • An aluminum powder containing a plurality of aluminum metal particles may be arranged on at least one surface of the substrate, or a green powder obtained by compacting the aluminum powder may be arranged, and the plurality of aluminum metals may be arranged.
  • a liquid composition such as a slurry containing particles may be arranged.
  • the liquid composition may be applied and arranged on the surface of the substrate by a known method such as spray coating, brush coating, roller coating, air knife coating, bar coating, spin coating, dipping, screen printing and the like.
  • the liquid composition may be applied so as to have a desired thickness of the sintered body in consideration of the composition.
  • the surface of the substrate may be pretreated before the plurality of aluminum metal particles are placed on the surface of the substrate.
  • the pretreatment may include a step of roughening the surface of the substrate.
  • the pretreatment is not particularly limited, and may be cleaning, etching, blasting, or the like.
  • the substrate may contain a resin or a metal.
  • the resin is burned by sintering, so that the substrate can be removed from the aluminum member 100 after sintering.
  • the substrate contains metal, the substrate can be left on the aluminum member 100.
  • the thickness of the substrate is more than 0 ⁇ m.
  • the thickness of the substrate 50 may be, for example, 1 mm or less, 100 ⁇ m or less, 10 ⁇ m or less, or 1 ⁇ m or less, depending on the application.
  • the metal substrate may be made of the same material as the substrate 50 described above.
  • the aluminum powder or composition may contain a plurality of aluminum metal particles, as well as a pore-forming material, a binder, a sintering aid, a surfactant, a solvent, and the like, if necessary. As these, known ones can be used.
  • the content of the aluminum metal particles in the composition is preferably 5% by mass or more, more preferably 10% by mass or more, and further preferably 15% by mass or more.
  • the content of the aluminum metal particles in the composition is preferably 30% by mass or less, more preferably 25% by mass or less, and further preferably 20% by mass or less.
  • the pore-forming material is a material that promotes the formation of voids 16 in the sintered body.
  • the pore-forming material may be, for example, particles containing a polymer material.
  • the pore-forming material preferably has low solubility in a solvent described later.
  • the polymer material may contain a polysaccharide or a resin.
  • the polysaccharide may include, for example, starch.
  • the resin may contain polyolefins such as polyethylene or polypropylene.
  • the average particle size of the pore-forming material is preferably 0.1 ⁇ m or more and 20 ⁇ m or less. By setting the average particle size of the pore-forming material to 0.1 ⁇ m or more, the average pore diameter can be easily set to 2.5 ⁇ m or more. By setting the average particle size of the pore-forming material to 20 ⁇ m or less, the average pore diameter can be easily set to 20 ⁇ m or less.
  • the average particle size of the pore-forming material is more preferably 0.5 ⁇ m or more, and further preferably 1 ⁇ m or more.
  • the average particle size of the pore-forming material is preferably 10 ⁇ m or less, and more preferably 8 ⁇ m or less.
  • the average particle size of the pore-forming material is a D50 value obtained by measuring the particle size distribution on a volume basis by a laser diffraction method.
  • the content of the pore-forming material in the composition is preferably 0.5% by mass or more, more preferably 1% by mass or more, and further preferably 3% by mass or more.
  • the content of the pore-forming material in the composition is preferably 20% by mass or less, more preferably 10% by mass or less, and further preferably 8% by mass or less.
  • the binder preferably has high solubility in a solvent described later.
  • the binder is, for example, a carboxy-modified polyolefin resin, vinyl acetate resin, vinyl chloride resin, vinyl chloride-vinyl acetate copolymer resin, vinyl alcohol resin, butyral resin, vinyl fluoride resin, acrylic resin, polyester resin, urethane resin, epoxy resin. , Urea resin, phenol resin, acrylonitrile resin, nitrocellulose resin, paraffin wax, or synthetic resin such as polyethylene wax, or resin such as wax, tar, sardine, urushi, pine fat, or natural resin such as beeswax. May be good.
  • the binder content in the composition is preferably 0.5% by mass or more, and more preferably 0.75% by mass or more.
  • the binder content in the composition is preferably 10% by mass or less, more preferably 7% by mass or less.
  • the solvent may contain an organic solvent such as water, ethanol, toluene, ketones, or esters.
  • an organic solvent such as water, ethanol, toluene, ketones, or esters.
  • the laminated board in which the composition is applied to the substrate may be dried at a temperature of 20 ° C. or higher and 300 ° C. or lower for 1 to 30 minutes.
  • the sintering temperature is not particularly limited, but is preferably 560 ° C. or higher and 660 ° C. or lower. By setting the sintering temperature to 560 ° C. or higher, the strength of the sintered body can be improved. By setting the sintering temperature to 660 ° C. or lower, it is possible to prevent the plurality of aluminum metal particles from melting.
  • the sintering temperature is more preferably 570 ° C. or higher, and even more preferably 580 ° C. or higher. Further, the sintering temperature is more preferably 650 ° C. or lower, and further preferably 620 ° C. or lower.
  • the sintering time depends on the sintering temperature and the like, but may be, for example, about 5 hours to 24 hours.
  • the sintering atmosphere is not particularly limited, and may be, for example, a vacuum atmosphere, an inert gas atmosphere, an oxidizing gas atmosphere (atmosphere), a reducing gas atmosphere, or the like. Among these, the sintering atmosphere is preferably a vacuum atmosphere or a reducing gas atmosphere.
  • the sintering conditions may be normal pressure, reduced pressure, or pressurized pressure.
  • the composition contains a pore-forming material
  • the pore-forming material can be gently burned to form more uniformly dispersed voids 16 in the sintered body.
  • the heating temperature is preferably 250 ° C. or higher, more preferably 280 ° C. or higher.
  • the heating temperature is preferably 460 ° C. or lower, and more preferably 430 ° C. or lower.
  • the heating time is preferably 5 hours or more and 20 hours or less. By setting the heating time to 5 hours or more, the voids 16 dispersed more uniformly can be formed in the sintered body. By setting the heating time to 20 hours or less, it is possible to prevent the sintering of each aluminum metal particle from proceeding and to form voids 16 in the sintered body in which the aluminum metal particles are more uniformly dispersed.
  • the heating time is more preferably 7 hours or more, and more preferably 15 hours or less.
  • the sintering atmosphere may be a vacuum atmosphere, an inert gas atmosphere, or an oxidizing gas atmosphere.
  • the sintering conditions may be normal pressure, reduced pressure, or pressurized pressure.
  • the sintering step may include a first sintered layer forming step for obtaining a first sintered layer and a second sintered layer forming step for obtaining a second sintered layer.
  • a first sintered layer forming step a plurality of aluminum metal particles can be sintered to obtain a first sintered layer.
  • the plurality of aluminum metal particles may be placed on at least one surface of the substrate and then sintered, as described above.
  • a laminate in which a plurality of aluminum metal particles are arranged may be sintered on the surface of the first sintered layer.
  • the average particle size, aspect ratio, or composition of the constituent materials and compositions of the plurality of aluminum metal particles used, or the type or average of the pore-forming material may be different.
  • the filling rate of the sintered body may be 10% by volume to 40% by volume.
  • the filling rate of the sintered body may be 10% by volume to 10% by volume or more.
  • a porous body 40 having a porosity of not less than the lower limit of a desired range can be obtained after performing the outer shell forming step and the removing step. It will be easier.
  • the filling rate is preferably 15% by volume or more, and more preferably 20% by volume or more.
  • the filling rate is preferably 35% by volume or less, and more preferably 30% by volume or less.
  • the filling rate is the ratio of the volume of the portion excluding the volume of all the voids in the sintered body to the total volume of the sintered body.
  • the filling rate can be measured by, for example, a mercury intrusion method.
  • the sintered body is anodized to form an outer shell 12 containing aluminum oxide on the surface of each aluminum metal particle contained in the plurality of aluminum metal particles.
  • an anode on which a sintered body is installed and a cathode on which stainless steel (SUS) is installed are immersed in an electrolytic solution and electrolyzed.
  • the electrolytic solution used to form the outer shell is not particularly limited.
  • an aqueous solution of boric acid, ammonium borate, phosphoric acid, pyrophosphate, ammonium phosphate, ammonium adipate, sulfuric acid, or oxalic acid can be used.
  • the conditions for forming the outer shell are not particularly limited, but for example, the voltage is 5V to 500V.
  • the outer shell formation may be carried out in a single step, or may be carried out in a plurality of different steps.
  • removing step a part of the surface of the outer shell 12 is removed.
  • a part of the outer shell 12 formed in the outer shell forming step is removed, and the voids and cracks remaining in the outer shell 12 are exposed.
  • the surface of the outer shell 12 can be roughened by removing (eroding) the outer shell 12, and the concave portion 13 can be formed on the surface of the outer shell 12.
  • the removing step is carried out, for example, by immersing the member on which the outer shell 12 is formed in the outer shell forming step in the removing liquid.
  • At least one of pure aluminum and aluminum alloy contained in the plurality of aluminum metal particles may be eluted.
  • the pure aluminum and the aluminum alloy contained in the aluminum metal particles may be melted inside the outer shell 12 and eluted outside the outer shell 12.
  • a cavity 17 is created inside the outer shell 12.
  • the outer shell 12 remains as a shell-like structure, so that the aluminum particles 15 are formed. That is, hollow aluminum particles including the outer shell 12 and the cavity 17 surrounded by the outer shell 12 are formed.
  • a series of continuous outer shells 12 are formed on the outer surfaces of a plurality of adjacent aluminum metal particles.
  • the outer shell 12 derived from the plurality of aluminum metal particles remains in a continuous form by the outer shell forming step, and the inside of the aluminum metal particles is eluted by the removing step, and a plurality of cavities 17 are formed inside the outer shell 12. It is formed so as to be connected and continuous. As a result, the skeleton 11 in which a plurality of aluminum particles 15 are aggregated is formed.
  • the removing solution is not particularly limited as long as the surface of the aluminum oxide outer shell can be removed (eroded), but at least selected from the group consisting of phosphates, metal salts of phosphates, tartrate, hydrochloric acid, and metal salts of hydrochloric acid It is preferable that the solution is one in which one is dissolved, or at least one of a sodium hydroxide solution and an aqueous ammonia solution.
  • Phosphoric acids include, for example, orthophosphoric acid, phosphorous acid, hypophosphorous acid, and mixtures thereof.
  • Metals forming metal salts include, for example, aluminum, sodium, magnesium, calcium and zinc.
  • the content of the metal salts of phosphoric acids and phosphoric acids is preferably 0.1 g / L to 50 g / L, for example.
  • the treatment temperature of the phosphoric acid treatment is preferably, for example, 50 ° C. to 80 ° C.
  • the treatment time for the phosphoric acid treatment is preferably 1 minute to 60 minutes.
  • the sintering step, the outer shell forming step, and the removing step can be performed at least once in this order.
  • the number of times each step is carried out is not particularly limited, but it is preferable that the outer shell forming step and the removing step are alternately repeated after the sintering step. As a result, the removal of the outer shell 12 and the repair of the removed outer shell 12 are repeated, so that a good porous body 40 is formed.
  • the number of repetitions of the outer shell forming step and the removing step is not particularly limited because it is affected by the voltage conditions of the outer shell forming step and the processing time of the removing step. It may be 5 times or more, or 8 times or more. The number of repetitions of the outer shell forming step and the removing step may be 15 times or less, or 10 times or less.
  • the method for producing the aluminum member 100 according to the present embodiment may include a hydration treatment step, but when the hydration treatment step is performed, the outer shell forming step and the removing step are repeated thereafter.
  • the hydration treatment step is generally a step of forming a hydrated film of aluminum hydroxide on the surface of aluminum after the sintering step, and the aluminum having a porous surface is heated with warm water such as boiling water. This is the process of heat treatment.
  • the fine irregularities on the surface are covered with aluminum hydroxide, the diffuse reflection of light is hindered, and the whiteness of the aluminum member may decrease. Further, since the porous portion of the aluminum member is easily clogged with aluminum hydroxide, the diffuse reflection of light is hindered and the whiteness of the aluminum member is lowered.
  • the whiteness of the aluminum member 100 can be further improved.
  • the hydrated film when the hydrated film is formed by the hydration treatment step, the hydrated film can be further melted by the outer shell forming step and the removing step. As a result, the hydrated film can be reduced or eliminated, and the convex portion 14 can be formed on the surface of the outer shell 12. Then, the whiteness can be improved by the convex portion 14. At this time, it is considered that the convex portion 14 can be formed by the remaining hydrated film or anodized film.
  • the outer shell forming step and the removing step the outer shell is incorporated into the anodized film in order from the hydrated film on the inner layer side, and the outer shell composed of the anodized film and the rest of the hydrated film on the surface of the aluminum metal particles. 12 arises.
  • a layered structure is formed in which the aluminum metal particles, the anodic oxide film, and the rest of the hydrated film are laminated in this order.
  • a convex portion 14 is formed on the outer shell 12.
  • the aluminum metal particles are eluted by the removal step, so that a layer structure is formed in which the anodic oxide film and the rest of the hydrated film are laminated in this order so as to surround the cavity 17, and undergo anodic oxidation treatment and erosion.
  • the convex portion 14 is formed on the outer shell 12.
  • the concave portion 13 can be formed together with the convex portion 14 on the outer shell 12 depending on the conditions of the anodizing treatment and the erosion. Further, the recess 13 can be formed on the surface of the outer shell 12 by performing anodizing treatment and erosion to the extent that the hydrated film does not remain.
  • the convex portion 14 is formed by (the rest of) the hydrated film or the anodized film.
  • the secondary rough surface structure 20 is formed by forming voids 16 in the porous body 40 through the sintering step and the formation and removal of the anodized film by the outer shell forming step and the removing step. .. Further, by the outer shell forming step and the removing step, a recess 13 is formed on the surface of the outer shell 12, and the primary rough surface structure 10 is formed. Further, by the outer shell forming step and the removing step after the hydration treatment step, a convex portion 14 is formed on the surface of the outer shell 12, and the primary rough surface structure 10 is formed.
  • the method for manufacturing the aluminum member 100 includes a sintering step of sintering a plurality of aluminum metal particles to obtain a sintered body.
  • the above method includes an outer shell forming step of anodizing the sintered body to form an outer shell 12 containing aluminum oxide on the surface of each aluminum metal particle contained in the plurality of aluminum metal particles.
  • the above method includes a removing step of removing a part of the surface of the outer shell 12. In the above method, the outer shell forming step and the removing step are alternately repeated.
  • Each aluminum metal particle contains at least one of pure aluminum and an aluminum alloy.
  • the average particle size of the plurality of aluminum metal particles is 0.1 to 20 ⁇ m, and the filling rate of the sintered body is 10% by volume to 40% by volume. Further, in the above method, at least one of the plurality of concave portions 13 and the plurality of convex portions 14 is formed on the surface of the outer shell 12 by the outer shell forming step and the removing step.
  • the porosity of the aluminum member is 85% by volume or more.
  • the average spacing between the recesses 13 included in the plurality of recesses 13 or the average spacing between the convex portions 14 included in the plurality of convex portions 14 is 100 nm to 600 nm.
  • Example 1 (Slurry preparation) First, a slurry was prepared by uniformly dispersing 15 parts by mass of aluminum metal particles, 11 parts by mass of a pore-forming material, and 5.2 parts by mass of a binder in a solvent of 68.8 parts by mass.
  • the aluminum metal particles (AHZL58FN manufactured by Toyo Aluminum Co., Ltd.) are pure aluminum (JIS A1080) having a purity of 99.80% by mass or more.
  • the aluminum metal particles were substantially spherical and had an average particle diameter of 3 ⁇ m.
  • As the pore-forming material starch having an average particle size of 7 ⁇ m (Nikka Rico (registered trademark) AS-500S manufactured by Nikka Co., Ltd.) was used.
  • An ethyl cellulose resin was used as the binder. Butyl acetate was used as the solvent.
  • a slurry was applied to one surface of an aluminum substrate having a thickness of 30 ⁇ m using a comma coater (registered trademark) of HIRANO TECSEED Co., Ltd. so that the thickness of the sintered body was 50 ⁇ m.
  • the slurry was dried at 100 ° C. for 1.5 minutes, then heated at 350 ° C. for 5 hours in an air atmosphere, and further sintered at 620 ° C. to 640 ° C. for 10 hours in an argon gas atmosphere. In this way, a laminate in which the sintered body was provided on the aluminum substrate was produced.
  • the filling rate of the sintered body was 29% by volume.
  • the hydrated laminate was anodized to form an outer shell containing aluminum oxide on the surface of the aluminum metal particles.
  • the laminate installed on the anode and the stainless steel (SUS) installed on the cathode were immersed in a boric acid electrolytic solution having a concentration of 80 g / L and an electrolytic solution temperature of 70 ° C. .. Then, it was anodized at a voltage of 250 V for 10 minutes.
  • Example 2 A slurry was prepared by uniformly dispersing 15 parts by mass of aluminum metal particles, 8 parts by mass of a pore-forming material, and 5.4 parts by mass of a binder in a solvent of 71.6 parts by mass. Further, the filling rate of the sintered body was set to 32% by volume. An aluminum member was produced by the same method as in Example 1 except for the above.
  • Example 3 A slurry was prepared by uniformly dispersing 15 parts by mass of aluminum metal particles, 8 parts by mass of a pore-forming material, and 5.4 parts by mass of a binder in a solvent of 71.6 parts by mass. The average particle size of the aluminum metal particles was set to 5 ⁇ m. The slurry was sintered at 610 ° C. for 10 hours in an argon gas atmosphere. An aluminum member was produced by the same method as in Example 1 except for the above.
  • Example 4 A slurry was prepared by uniformly dispersing 15 parts by mass of aluminum metal particles, 8 parts by mass of a pore-forming material, and 5.4 parts by mass of a binder in a solvent of 71.6 parts by mass. The average particle size of the aluminum metal particles was set to 5 ⁇ m. The slurry was sintered at 640 ° C. for 10 hours in an argon gas atmosphere. An aluminum member was produced by the same method as in Example 1 except for the above.
  • Example 5 A slurry was prepared by uniformly dispersing 15 parts by mass of aluminum metal particles, 6 parts by mass of a pore-forming material, and 5.5 parts by mass of a binder in a solvent of 73.5 parts by mass. The average particle size of the aluminum metal particles was set to 5 ⁇ m. The slurry was sintered at 610 ° C. for 10 hours in an argon gas atmosphere. The filling rate of the sintered body was 31% by volume. An aluminum member was produced by the same method as in Example 1 except for the above.
  • Example 6 A slurry was prepared by uniformly dispersing 15 parts by mass of aluminum metal particles, 6 parts by mass of a pore-forming material, and 5.5 parts by mass of a binder in a solvent of 73.5 parts by mass. The average particle size of the aluminum metal particles was set to 5 ⁇ m. The slurry was sintered at 640 ° C. for 10 hours in an argon gas atmosphere. The filling rate of the sintered body was 31% by volume. An aluminum member was produced by the same method as in Example 1 except for the above.
  • Example 7 A slurry was prepared by uniformly dispersing 15 parts by mass of aluminum metal particles, 6 parts by mass of a pore-forming material, and 5.5 parts by mass of a binder in a solvent of 73.5 parts by mass. The average particle size of the aluminum metal particles was set to 5 ⁇ m. A slurry was applied to one surface of the aluminum substrate so that the thickness of the sintered body was 150 ⁇ m. The slurry was sintered at 640 ° C. for 10 hours in an argon gas atmosphere. The filling rate of the sintered body was set to 36% by volume. An aluminum member was produced by the same method as in Example 1 except for the above.
  • Example 8 A slurry was prepared by uniformly dispersing 15 parts by mass of aluminum metal particles, 6 parts by mass of a pore-forming material, and 5.5 parts by mass of a binder in a solvent of 73.5 parts by mass. The average particle size of the aluminum metal particles was set to 5 ⁇ m. A slurry was applied to one surface of the aluminum substrate so that the thickness of the sintered body was 150 ⁇ m. The slurry was sintered at 610 ° C. for 10 hours in an argon gas atmosphere. The filling rate of the sintered body was set to 36% by volume. An aluminum member was produced by the same method as in Example 1 except for the above.
  • Example 9 A slurry was prepared by uniformly dispersing 15 parts by mass of aluminum metal particles, 3 parts by mass of a pore-forming material, and 5.7 parts by mass of a binder in a solvent of 76.3 parts by mass. The average particle size of the aluminum metal particles was set to 9 ⁇ m. A slurry was applied to one surface of the aluminum substrate so that the thickness of the sintered body was 100 ⁇ m. The slurry was sintered at 610 ° C. for 10 hours in an argon gas atmosphere. The filling rate of the sintered body was 32% by volume. An aluminum member was produced by the same method as in Example 1 except for the above.
  • Example 10 A slurry was prepared by uniformly dispersing 15 parts by mass of aluminum metal particles, 3 parts by mass of a pore-forming material, and 5.7 parts by mass of a binder in a solvent of 76.3 parts by mass. The average particle size of the aluminum metal particles was set to 15 ⁇ m. A slurry was applied to one surface of the aluminum substrate so that the thickness of the sintered body was 100 ⁇ m. The slurry was sintered at 610 ° C. for 10 hours in an argon gas atmosphere. An aluminum member was produced by the same method as in Example 1 except for the above.
  • Example 11 A slurry was prepared by uniformly dispersing 15 parts by mass of aluminum metal particles, 8 parts by mass of a pore-forming material, and 5.4 parts by mass of a binder in a solvent of 71.6 parts by mass. The average particle size of the aluminum metal particles was set to 5 ⁇ m. The slurry was sintered at 640 ° C. for 10 hours in an argon gas atmosphere. The filling rate of the sintered body was 31% by volume.
  • the first outer shell forming step anodizing treatment was performed at a voltage of 250 V for 10 minutes.
  • the first outer shell removing step after thoroughly washing the laminate forming the outer shell with water, the outer shell is immersed in a phosphoric acid aqueous solution having a concentration of 50 g / L and a temperature of 70 ° C. for 10 minutes. Part was removed. The first outer shell formation and the first outer shell removal were performed once each.
  • a second outer shell forming step anodizing was performed at a voltage of 250 V for 10 minutes.
  • the second outer shell removing step after thoroughly washing the laminate forming the outer shell with water, the outer shell is immersed in a phosphoric acid aqueous solution having a concentration of 50 g / L and a temperature of 70 ° C. for 15 minutes. Part was removed. The second outer shell formation and the second outer shell removal were repeated four times in this order. Except for the above, an aluminum member was produced in the same manner as in Example 1.
  • Example 12 A slurry was prepared by uniformly dispersing 15 parts by mass of aluminum metal particles, 8 parts by mass of a pore-forming material, and 5.4 parts by mass of a binder in a solvent of 71.6 parts by mass. The average particle size of the aluminum metal particles was set to 5 ⁇ m. The slurry was sintered at 640 ° C. for 10 hours in an argon gas atmosphere. The filling rate of the sintered body was 31% by volume.
  • the first outer shell forming step anodizing treatment was performed at a voltage of 250 V for 10 minutes.
  • the first outer shell removing step after thoroughly washing the laminate forming the outer shell with water, the outer shell is immersed in a phosphoric acid aqueous solution having a concentration of 50 g / L and a temperature of 70 ° C. for 10 minutes. Part was removed. The first outer shell formation and the first outer shell removal were performed once each.
  • a second outer shell forming step anodizing was performed at a voltage of 250 V for 10 minutes.
  • the second outer shell removing step after thoroughly washing the laminate forming the outer shell with water, the outer shell is immersed in a phosphoric acid aqueous solution having a concentration of 50 g / L and a temperature of 70 ° C. for 25 minutes. Part was removed. The second outer shell formation and the second outer shell removal were repeated twice in this order. Except for the above, an aluminum member was produced in the same manner as in Example 1.
  • Example 13 A slurry was prepared by uniformly dispersing 15 parts by mass of aluminum metal particles, 8 parts by mass of a pore-forming material, and 5.4 parts by mass of a binder in a solvent of 71.6 parts by mass. The average particle size of the aluminum metal particles was set to 5 ⁇ m. The slurry was sintered at 640 ° C. for 10 hours in an argon gas atmosphere. The filling rate of the sintered body was 31% by volume.
  • the first outer shell forming step anodizing treatment was performed at a voltage of 600 V for 10 minutes. Then, after the laminate on which the outer shell was formed was sufficiently washed with water, the laminate was heat-treated at 500 ° C. for 2 minutes.
  • anodizing treatment was performed at a voltage of 600 V for 10 minutes.
  • an outer shell removing step after thoroughly washing the laminate forming the outer shell with water, the outer shell is partially immersed in a phosphoric acid aqueous solution having a concentration of 50 g / L and a temperature of 70 ° C. for 15 minutes. Removed. The second outer shell formation and outer shell removal were repeated 5 times in this order. Except for the above, an aluminum member was produced in the same manner as in Example 1.
  • Example 1 A slurry was prepared by uniformly dispersing 15 parts by mass of aluminum metal particles, 0 parts by mass of a pore-forming material, and 6.0 parts by mass of a binder in a solvent of 79.1 parts by mass. Further, the filling rate of the sintered body was set to 56% by volume. An aluminum member was produced by the same method as in Example 1 except for the above.
  • Example 2 A slurry was prepared by uniformly dispersing 15 parts by mass of aluminum metal particles, 0 parts by mass of a pore-forming material, and 6.0 parts by mass of a binder in a solvent of 79.1 parts by mass. Further, the filling rate of the sintered body was set to 52% by volume. An aluminum member was produced by the same method as in Example 1 except for the above.
  • Example 3 A slurry was prepared by uniformly dispersing 15 parts by mass of aluminum metal particles, 6 parts by mass of a pore-forming material, and 5.5 parts by mass of a binder in a solvent of 73.5 parts by mass. Further, the filling rate of the sintered body was set to 37% by volume. An aluminum member was produced by the same method as in Example 1 except for the above.
  • a slurry was prepared by uniformly dispersing 15 parts by mass of aluminum metal particles, 3 parts by mass of a pore-forming material, and 5.7 parts by mass of a binder in a solvent of 76.3 parts by mass.
  • the average particle size of the aluminum metal particles was set to 5 ⁇ m.
  • the slurry was sintered at 610 ° C. for 10 hours in an argon gas atmosphere. The filling rate of the sintered body was 38% by volume.
  • An aluminum member was produced by the same method as in Example 1 except for the above.
  • a slurry was prepared by uniformly dispersing 15 parts by mass of aluminum metal particles, 0 parts by mass of a pore-forming material, and 6.0 parts by mass of a binder in a solvent of 79.1 parts by mass.
  • the average particle size of the aluminum metal particles was set to 5 ⁇ m.
  • the slurry was sintered at 640 ° C. for 10 hours in an argon gas atmosphere.
  • the filling rate of the sintered body was set to 52% by volume.
  • An aluminum member was produced by the same method as in Example 1 except for the above.
  • a slurry was prepared by uniformly dispersing 15 parts by mass of aluminum metal particles, 3 parts by mass of a pore-forming material, and 5.7 parts by mass of a binder in a solvent of 76.3 parts by mass.
  • the average particle size of the aluminum metal particles was set to 5 ⁇ m.
  • the slurry was sintered at 640 ° C. for 10 hours in an argon gas atmosphere.
  • the filling rate of the sintered body was set to 40% by volume.
  • An aluminum member was produced by the same method as in Example 1 except for the above.
  • a slurry was prepared by uniformly dispersing 15 parts by mass of aluminum metal particles, 0 parts by mass of a pore-forming material, and 6.0 parts by mass of a binder in a solvent of 79.1 parts by mass.
  • the average particle size of the aluminum metal particles was set to 5 ⁇ m.
  • the slurry was sintered at 610 ° C. for 10 hours in an argon gas atmosphere.
  • the filling rate of the sintered body was set to 43% by volume.
  • An aluminum member was produced by the same method as in Example 1 except for the above.
  • a slurry was prepared by uniformly dispersing 15 parts by mass of aluminum metal particles, 0 parts by mass of a pore-forming material, and 6.0 parts by mass of a binder in a solvent of 79.1 parts by mass.
  • the average particle size of the aluminum metal particles was set to 5 ⁇ m.
  • a slurry was applied to one surface of the aluminum substrate so that the thickness of the sintered body was 100 ⁇ m.
  • the slurry was sintered at 610 ° C. for 10 hours in an argon gas atmosphere.
  • the filling rate of the sintered body was set to 46% by volume.
  • An aluminum member was produced by the same method as in Example 1 except for the above.
  • a slurry was prepared by uniformly dispersing 15 parts by mass of aluminum metal particles, 0 parts by mass of a pore-forming material, and 6.0 parts by mass of a binder in a solvent of 79.1 parts by mass.
  • the average particle size of the aluminum metal particles was set to 5 ⁇ m.
  • a slurry was applied to one surface of the aluminum substrate so that the thickness of the sintered body was 100 ⁇ m.
  • the slurry was sintered at 640 ° C. for 10 hours in an argon gas atmosphere. The filling rate of the sintered body was set to 49% by volume.
  • An aluminum member was produced by the same method as in Example 1 except for the above.
  • a slurry was prepared by uniformly dispersing 15 parts by mass of aluminum metal particles, 0 parts by mass of a pore-forming material, and 6.0 parts by mass of a binder in a solvent of 79.1 parts by mass.
  • the average particle size of the aluminum metal particles was set to 5 ⁇ m.
  • a slurry was applied to one surface of the aluminum substrate so that the thickness of the sintered body was 150 ⁇ m.
  • the slurry was sintered at 610 ° C. for 10 hours in an argon gas atmosphere. The filling rate of the sintered body was set to 50% by volume.
  • An aluminum member was produced by the same method as in Example 1 except for the above.
  • a slurry was prepared by uniformly dispersing 15 parts by mass of aluminum metal particles, 0 parts by mass of a pore-forming material, and 6.0 parts by mass of a binder in a solvent of 79.1 parts by mass.
  • the average particle size of the aluminum metal particles was set to 5 ⁇ m.
  • Slurry was applied to both surfaces of the aluminum substrate so that the thickness of the sintered body was 25 ⁇ m.
  • the slurry was sintered at 610 ° C. for 10 hours in an argon gas atmosphere. The filling rate of the sintered body was set to 51% by volume.
  • An aluminum member was produced by the same method as in Example 1 except for the above.
  • a slurry was prepared by uniformly dispersing 15 parts by mass of aluminum metal particles, 0 parts by mass of a pore-forming material, and 6.0 parts by mass of a binder in a solvent of 79.1 parts by mass.
  • the average particle size of the aluminum metal particles was set to 9 ⁇ m.
  • Slurry was applied to both surfaces of the aluminum substrate so that the thickness of the sintered body was 25 ⁇ m.
  • the slurry was sintered at 610 ° C. for 10 hours in an argon gas atmosphere.
  • the filling rate of the sintered body was set to 48% by volume.
  • An aluminum member was produced by the same method as in Example 1 except for the above.
  • Example 13 A slurry was prepared by uniformly dispersing 15 parts by mass of aluminum metal particles, 0 parts by mass of a pore-forming material, and 6.0 parts by mass of a binder in a solvent of 79.1 parts by mass. Further, the filling rate of the sintered body was set to 56% by volume. Outer shell formation and outer shell removal were performed only once. Except for the above, an aluminum member was produced in the same manner as in Example 1.
  • a slurry was prepared by uniformly dispersing 15 parts by mass of aluminum metal particles, 3 parts by mass of a pore-forming material, and 5.7 parts by mass of a binder in a solvent of 76.3 parts by mass.
  • the average particle size of the aluminum metal particles was set to 9 ⁇ m.
  • the slurry was sintered at 610 ° C. for 10 hours in an argon gas atmosphere.
  • the filling rate of the sintered body was 32% by volume.
  • the immersion time of the phosphoric acid aqueous solution was set to 5 minutes, and outer shell formation and outer shell removal were repeated 5 times. Except for the above, an aluminum member was produced in the same manner as in Example 1.
  • a slurry was prepared by uniformly dispersing 15 parts by mass of aluminum metal particles, 3 parts by mass of a pore-forming material, and 5.7 parts by mass of a binder in a solvent of 76.3 parts by mass.
  • the average particle size of the aluminum metal particles was set to 15 ⁇ m.
  • the slurry was sintered at 610 ° C. for 10 hours in an argon gas atmosphere.
  • the immersion time of the phosphoric acid aqueous solution was set to 5 minutes, and outer shell formation and outer shell removal were repeated 5 times. Except for the above, an aluminum member was produced in the same manner as in Example 1.
  • the surface or cross section of the aluminum member according to Example 1 and Comparative Example 13 was observed by scanning electron micrographs. Further, in the aluminum members obtained in each example, the filling rate of the sintered body, the porosity of the porous body, the outer shell thickness, the average spacing of the concave or convex portions, the diameter of the concave or convex portions of the primary structure, and the concave portions. The depth or the height of the convex portion was evaluated as follows. Further, in the aluminum members obtained in each example, the average pore diameter of the voids and cavities, the arithmetic average roughness Sa, the period of the tertiary rough surface structure, the L * value, the water suction height, and the water suction time are determined. Each was evaluated as follows.
  • the surface of the outer shell was observed with a scanning electron microscope ULTRA plus manufactured by Carl Zeiss Co., Ltd., and the average spacing between the concave portions or the convex portions was measured.
  • the average spacing of each Example and each Comparative Example was obtained from the average value of the average spacing of the three locations calculated from the different aluminum particles observed by the scanning electron microscope.
  • the number of intersections with the reference line was measured by counting the intersections between the reference line and the recess when a recess was present. When the convex portion was present, the measurement was performed by counting the intersections of the reference line and the convex portion. Further, when the concave portion and the convex portion were present, the measurement was performed by counting the intersections of the reference line and the convex portion.
  • the surface of the outer shell was observed with a scanning electron microscope ULTRA plus manufactured by Carl Zeiss Co., Ltd., and the diameter of the recess was determined by averaging the diameter of the inlet portion of the recess.
  • the surface of the outer shell was observed with a scanning electron microscope ULTRA plus manufactured by Carl Zeiss Co., Ltd., and the diameter of the convex portion was determined by averaging the diameters of the portions having the largest convex portions.
  • the depth of the recess was determined by observing the cross section of the outer shell with a scanning electron microscope and calculating the average value obtained by measuring the distance from the entrance to the bottom of the recess.
  • the height of the convex portion was determined by observing the cross section of the outer shell with a scanning electron microscope and calculating the average value obtained by measuring the distance from the surface of the flat portion of the outer shell to the top of the convex portion.
  • the average pore diameter of the voids and cavities was measured by the mercury intrusion method.
  • the arithmetic mean roughness Sa of the surface of the aluminum member on the porous body side was measured according to ISO25178.
  • the measurement conditions for the arithmetic mean roughness Sa are as follows.
  • the water suction time was measured as follows. First, the aluminum member was immersed in pure water so that the plane direction of the aluminum member was perpendicular to the liquid surface. Then, after the aluminum member was immersed in pure water, the time during which water was sucked up to a height of 4 cm from the liquid surface by the capillary phenomenon was measured and evaluated as the water sucking time.
  • a primary rough surface structure having protrusions and recesses was formed on the surface of the aluminum members by the outer shell forming step and the removing step.
  • the average distance between these concave portions or convex portions was 100 nm to 600 nm, and the L * value of the aluminum member was 75 or more.
  • the average spacing between the concave portions or the convex portions was less than 100 nm or more than 600 nm, and the L * value of the aluminum members was less than 70. From these results, it is presumed that the average spacing between the concave portions or the convex portions contributes to the whiteness of the aluminum member.
  • the aluminum members according to Examples 1 to 13 had a porosity of 85% by volume or more and a water suction time of 200 seconds or less.
  • the porosity of the porous body was less than 85% by volume, and the water suction time was more than 200 seconds. From these results, it is inferred that the porosity of the porous body contributes to the water uptake time.
  • the aluminum member according to the embodiment has high whiteness and water suction performance.

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Abstract

L'invention concerne un organe en aluminium (100) comprenant un squelette (11) formé par l'agrégation d'une pluralité de particules d'aluminium (15), et un corps poreux (40) contenant une pluralité de lacunes (16) entourées par le squelette (11). Le squelette (11) contient une enveloppe externe (12) comprenant de l'oxyde d'aluminium, et une surface du squelette (11) est formée par l'enveloppe externe (12). L'enveloppe externe (12) possède au moins l'une parmi une pluralité de parties en retrait (13) et une pluralité de parties en saillie (14) sur une surface de celle-ci. Le diamètre particulaire moyen de la pluralité de particules d'aluminium (15) est de 0,1 à 20 µm, et la porosité du corps poreux (40) est d'au moins 85 % en volume. L'espace moyen entre les parties en retrait (13) incluses dans la pluralité de parties en retrait (13), ou l'espace moyen entre les parties en saillie (14) incluses dans la pluralité de parties en saillie (14), est de 100 à 600 nm.
PCT/JP2020/038847 2019-10-21 2020-10-15 Organe en aluminium, bande de test pour immunochromatographie, et procédé de production d'un organe en aluminium WO2021079813A1 (fr)

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JP2021554336A JP7235889B2 (ja) 2019-10-21 2020-10-15 アルミニウム部材、イムノクロマトグラフィー用テストストリップ及びアルミニウム部材の製造方法
CN202080073043.6A CN114555869B (zh) 2019-10-21 2020-10-15 铝构件、免疫层析用测试试条及铝构件的制造方法

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