WO2020243988A1 - 一种样本分析系统及其控制方法、样本分析方法 - Google Patents
一种样本分析系统及其控制方法、样本分析方法 Download PDFInfo
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- WO2020243988A1 WO2020243988A1 PCT/CN2019/091379 CN2019091379W WO2020243988A1 WO 2020243988 A1 WO2020243988 A1 WO 2020243988A1 CN 2019091379 W CN2019091379 W CN 2019091379W WO 2020243988 A1 WO2020243988 A1 WO 2020243988A1
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/0092—Scheduling
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1002—Reagent dispensers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1081—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
- G01N35/1083—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane with one horizontal degree of freedom
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
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- G01N2035/0465—Loading or unloading the conveyor
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- G—PHYSICS
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- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0474—Details of actuating means for conveyors or pipettes
- G01N2035/0482—Transmission
- G01N2035/0484—Belt or chain
Definitions
- the invention belongs to the technical field of automated analysis, and in particular relates to a sample analysis system, a control method thereof, and a sample analysis method.
- Existing automated analysis systems generally include various components related to sample distribution such as sample suction, transfer, and discharge, and various components related to sample analysis such as reagent suction, transfer, discharge, incubation, and measurement. These components have a structure that restricts each other. Working in coordination with the spatial coordination relationship, a set of completed sample distribution, reagent distribution, transfer, and measurement related modules and components together constitute an independent analysis system.
- the components of this system are designed by a complete set of plans.
- the disassembly of components or modules will cause the system to fail to work normally, which is indivisible and does not have scalability.
- certain component resources will be wasted, the system has not reached its maximum efficiency, and cannot be freely combined and expanded efficiently.
- United States Patent US20180313861A1 discloses a sample analysis system. Its conveying device includes a robotic arm that conveys containers or container racks between two sample analysis devices and a base that supports the robotic arm. Using this conveying device, essentially It is still a sample transmission scheme, and has not improved the efficiency of the analyzer system from the analyzer level.
- the commercial automated analysis system pipeline implemented by the above patents is connected by multiple independent analysis systems with complete functions.
- the volume is huge, and the functional modules such as suction, discharge, quantification, etc. related to sample distribution, and reagent distribution, incubation, measurement, and mixing
- the evenly related modules are bound in the analysis system, are interdependent in structure, and are arranged as a combined instrument unit.
- the related modules of incubation and measurement functions are often rate-limiting steps. For example, in most immune reactions, the detection time of a single reaction reaches several minutes to tens of minutes, and the distribution of samples is aspiration, Transfer and discharge often do not require uncertain response time limits. In this case, the traditional assembly line analysis system solution of the complete analysis system combination will result in a large number of sample-related component resources not reaching the maximum efficiency, resulting in cost and efficiency , The waste of volume makes it impossible to expand efficiently.
- the embodiment of the present invention provides a sample analysis system, which aims to solve the problems of large volume, incapable of free combination, high efficiency, and expansion of the existing sample analysis system.
- a sample analysis system includes: a control device; a rail device that is controlled by the control device and carries an analysis cup; and is configured on the rail device to distribute samples to the analysis cup.
- the sample distribution node of the sample distribution node, the independent sample distribution node is used for the suction, transfer and discharge of the sample; is arranged on the track device, distributes the detection reagent to the analysis cup, and measures at least two independent samples of the mixed liquid in the analysis cup
- the independent reagent distribution and measurement node is used for the suction, transfer, and discharge of reagents and the measurement of the reagent and sample mixture; the analysis cup is used for containing samples, reagents and signal measurement.
- the embodiment of the present invention also provides that the track device includes a plurality of node tracks corresponding to the sample distribution node and the reagent distribution and measurement node, which are used to communicate with each node.
- the multiple node tracks are an integrated synchronous motion structure or free Split structure of splicing combination.
- the sample Under the control of the sample distribution control device, the sample is sucked, transferred, and discharged to the sample distribution device located in the analysis cup of the current node.
- the sample distribution node fixing frame is used to fix each part of the sample distribution node to an independent structure.
- the reagent Under the control of the reagent distribution and measurement control device, the reagent is sucked, transferred, and discharged to the reagent distribution and measurement device that is located in the current node analysis cup and performs measurement.
- the reagent distribution and measurement node fixing frame is used to fix each part of the reagent distribution and measurement node to an independent structure.
- the embodiment of the present invention also provides that the analysis system has parallelism
- the analysis system consists of a combination of a sample distribution node and a reagent distribution and measurement node to form a basic measurement function; a combination of more than the basic measurement function combination of reagent distribution and measurement nodes and sample distribution nodes constitute a parallel operation node,
- the basic measurement function can still realize the analysis process of the sample in the failure mode of the reagent distribution and measurement node and the sample distribution node that are more than the basic measurement function combination or the stop operation mode.
- the sample distribution node and the reagent distribution and measurement node are combined and configured on the track device according to different combination rules to form different sample analysis systems.
- the sample analysis system can be expanded by adding the sample distribution and reagent distribution and measurement nodes, and configuring the track device.
- the analysis cup distribution node is used to provide analysis cups to other nodes of the sample analysis system.
- An analysis cup distribution device that is controlled by the analysis cup distribution control device and loads the analysis cups on the track device in an orderly manner;
- the analysis cup distribution node fixing frame is used to fix each part of the analysis cup distribution node to an independent structure.
- the embodiment of the present invention also provides that the reagent distribution and measurement node further includes a mixing mechanism for uniformly mixing the sample, the reagent, and the mixed solution of the reagent and the sample.
- the reagent distribution and measurement node further includes a gripping mechanism and a movement mechanism.
- the gripping mechanism is used to grasp the analysis cup on the track or in the carrier.
- the movement mechanism It is used to drive the analysis cup grasped by the gripping mechanism to be transferred to the measurement position of the reagent distribution and measurement node.
- the embodiment of the present invention also provides that the reagent distribution and measurement node further includes a reagent storage module for storing analysis reagents.
- the embodiment of the present invention also provides that the analysis cup is a container made of solid material and used as a carrier for the distribution, transfer, and measurement of samples and reagents.
- a sample analysis system control method used for the control of the sample analysis system includes the following steps:
- a sample analysis method used in the sample analysis system includes the following steps:
- the analysis cup distribution node distributes the analysis cups on the rail device, and the analysis cup is transported to the sample distribution node through the rail device connected to multiple nodes;
- the reagent distribution and measurement node distributes analysis reagents to the analysis cup, and measures and analyzes the sample and reagent mixture in the analysis cup;
- the sample analysis system uses the analysis cup as the medium, it breaks the sample of traditional instruments by adopting relatively independent nodes with sample distribution function, relatively independent reagent distribution and measurement nodes, and the free combination and connection of the nodes through the track. Restricted by the physical coordination relationship between the distribution components and the sample analysis components, a fully automated analysis system with small size, high efficiency, high degree of freedom, and high scalability is realized; and because the nodes can be freely added, freely combined and connected to form different speeds The analysis system with analysis function greatly improves the utilization rate of the structural parts of the instrument, and is easy to install and maintain.
- Figure 1a is a schematic side view of the structure of the sample analysis system provided by the present invention.
- Figure 1b is another side view of the structure of the sample analysis system provided by the present invention.
- Figure 1c is a schematic top view of the structure of the sample analysis system provided by the present invention.
- Figure 2 is a schematic diagram of assembly and disassembly of the sample analysis system provided by the present invention
- Figure 3a is a schematic side view of the structure of the sample distribution node 1 of the sample analysis system provided by the present invention.
- Fig. 3b is a schematic structural diagram of another side view of the sample distribution node 1 of the sample analysis system provided by the present invention.
- Fig. 3c is a schematic top view of the structure of the sample distribution node 1 of the sample analysis system provided by the present invention.
- 4a is a schematic diagram of the side view structure of the reagent distribution and measurement node 2 of the sample analysis system provided by the present invention
- FIG. 4b is another schematic structural diagram of the reagent distribution and measurement node 2 of the sample analysis system provided by the present invention.
- 4c is a schematic diagram of the top view structure of the reagent distribution and measurement node 2 of the sample analysis system provided by the present invention.
- FIG. 5 is an embodiment of the measurement module 23 of the sample analysis system provided by the present invention.
- FIG. 6 is another embodiment of the measurement module 23 of the sample analysis system provided by the present invention.
- FIG. 7 is another embodiment of the measurement module 23 of the sample analysis system provided by the present invention.
- FIG. 8a is a schematic side view of the consumable distribution node 5 of the sample analysis system of the sample analysis system provided by the present invention.
- FIG. 8b is a schematic structural diagram of another side view of the consumable distribution node 5 of the sample analysis system of the sample analysis system provided by the present invention.
- 8c is a schematic top view of the consumable distribution node 5 of the sample analysis system of the sample analysis system provided by the present invention.
- Figure 9a is a schematic side view of the structure of a sample analysis system including an analysis cup distribution node provided by the present invention.
- FIG. 9b is a schematic diagram of another side view of the structure of the sample analysis system including the analysis cup distribution node provided by the present invention.
- 9c is a schematic top view of the structure of the sample analysis system including the distribution node of the analysis cup provided by the present invention.
- FIG. 10 is a schematic top view of the integrated structure of the track device 3 of the sample analysis system provided by the present invention.
- Figure 11 is a control process diagram of the control method of the sample analysis system provided by the present invention.
- Fig. 12 is a schematic diagram of node combination and expansion of the sample analysis system provided by the present invention.
- the invention uses expandable multiple independent sample distribution nodes, reagent distribution and measurement nodes, and is freely combined and spliced into different distributed sample analysis systems through a track device controlled by a control device.
- Figures 1a, 1b, and 1c are schematic diagrams of side and top views of the above-mentioned distributed sample analysis device.
- the present invention proposes a distributed sample analysis system, including Control device
- the rail device 3 Under the control of the control device, the rail device 3 that carries the analysis cup;
- At least one independent sample distribution node 1 configured on the track device 3 to distribute samples to the analysis cup, the independent sample distribution node 1 being used for sample absorption, transfer, and discharge;
- the track device 3 is configured on the track device 3 to distribute detection reagents to the analysis cup and measure at least two independent reagent distribution and measurement nodes 2 of the mixed solution in the analysis cup.
- the independent reagent distribution and measurement nodes 2 are used for reagent distribution Suction, transfer, discharge, and measurement of reagent and sample mixture; the analysis cup is used to contain samples, reagents and signal measurement.
- Figure 3a, Figure 3b, Figure 3c, Figure 2 is a schematic diagram of the assembly and disassembly of the above distributed sample analysis system
- Figure 3a, Figure 3b, Figure 3c is the implementation of the above sample distribution node 1 including the analysis cup distribution module
- the side view and top view of the schematic diagram, the above-mentioned distributed sample analysis system can be specifically formed by a sample distribution node 1 including an analysis cup distribution module 14 and two reagent distribution and measurement nodes 2 through the detachable splicing combination of the track 3.
- the analysis cup distribution module 14 of the sample distribution node 1 provides a batch of analysis cups 4 to the node track 31 of the track device 3, and the sample transfer module of the sample distribution node The sample is transferred to the analysis cup 4, and then transported to the position of the reagent distribution and measurement node 2 through the rail device 3, and then the measurement and analysis are completed at the reagent distribution and measurement node 2.
- the above-mentioned nodes are independent functional units and are controlled by the above-mentioned control devices. For example, when a reagent distribution and measurement node 2 needs to be removed, the node track 32 can be retained, so that the normal use of the sample analysis system is not affected, which is convenient Maintenance; the node track 32 and the reagent distribution and measurement node 2 can also be disassembled and removed together, and the remaining nodes continue to be spliced for use, and new nodes can be added to realize the free combination and efficient expansion of the above-mentioned sample analysis system.
- the above-mentioned sample analysis system can select a plurality of sample distribution nodes 1 and reagent distribution and measurement nodes 2 according to the combination rule, and control the node track corresponding to the selected node through the above-mentioned control device, and assemble it on the above-mentioned track device 3.
- the track device 3 includes multiple nodal tracks, which can be an integrated synchronous motion structure or a split structure that is freely spliced and combined.
- Different combination rules can be expanded by adding sample distribution node 1 and reagent distribution and measurement node 2 and deploying them on the track device 3 to obtain different sample analysis systems.
- Combination rules can include speed priority, sample priority, resource priority, and so on.
- the above-mentioned sample analysis system has parallelism, that is, the sample analysis system can be composed of a sample distribution node 1 and a reagent distribution and measurement node 2 to form a basic measurement function; more than the basic measurement function combination of reagent distribution and measurement The node and the sample distribution node constitute a parallel operation node.
- the basic measurement system of the sample analysis system is based on more than the basic measurement function combination of reagent distribution and measurement node 2 and sample distribution node 1 failure mode or shutdown mode The measurement function can still realize the basic analysis process of the sample.
- the reagent distribution and measurement nodes can be appropriately added
- the number of 2 (such as 2) is measured in parallel under the deployment of the control system, that is, samples can be allocated to the above-mentioned multiple reagent distribution and measurement nodes 2 successively, and the test can be performed at the same time, thereby improving the test efficiency; if there is one of them If the reagent distribution and measurement node 2 fails or stops running, the remaining nodes can still continue to run to achieve corresponding analysis.
- the parallelism of the sample analysis system does not affect the normal operation of the entire system, and is convenient for maintenance and repair.
- the above-mentioned sample distribution node 1 includes a sample distribution control device; connected to the sample distribution control device, controlled by the sample distribution control device, sucks, transfers, and discharges samples to The sample distribution device in the analysis cup of the current node; the sample distribution node fixing frame 12 is used to fix each part of the sample distribution node to an independent structure.
- the aforementioned sample distribution device further includes a node track module 31, a first analysis cup distribution module 14, a sample transport module 11, and a sample loading area 13.
- the suction and discharge component 111 on the sample transfer module 11 sucks samples from the sample tube on the sample rack 131 in the sample loading area 13, and then moves the suction and discharge component 111 to the node rail module 31 through the cooperation of the rail 112 and the sample transfer module 11 for analysis Where the cup 4 is located, and discharge the sample liquid into the analysis cup 4.
- the suction and discharge component 111 includes, but is not limited to, a quantitative liquid suction and discharge component driven by pneumatic, electric, and hydraulic brakes;
- the component structure 1111 of the suction sample can be a tube-shaped structure such as a sample needle or a sample tube, which can be quickly sucked sample.
- the node track module 31 is used for the transmission of the analysis cup 4.
- the analysis cup 4 can be directly placed on the track and can be transmitted with the track through mechanical driving methods such as fixed coordination, friction coordination, and uneven structure coordination.
- the upper analysis cup is preferably in the form of a continuous cup.
- the above-mentioned rails include, but are not limited to, belts, gears, screw rods and other mechanical design forms used for transmission movement; in other possible embodiments, the form in which the analysis cup 4 is placed on the node track 31 can be replaced by the analysis cup 4 loading
- the carrier 34 is a solid structure capable of accommodating the analysis cup 4.
- the sample distribution node fixing frame 12 is used to fix the modules and components integrated in the sample distribution node 1.
- the entire sample distribution node 1 is fixed with an independent surface shell 121 (refer to Figure 1a) to form a relatively independent functional structure and facilitate integration Other node combinations.
- the sample loading area 13 is used as the sample input area, which can facilitate the node track 31 to transfer samples to other nodes; the sample loading area 13 is directly placed manually, imported through an automatic motion mechanism (not the same mechanism as the above track), etc.
- the sample can be a direct blood collection tube, a sample pre-distributed to the container manually or automatically.
- the first analysis cup distribution module 14 is used to quickly provide the analysis cup 4.
- a large number of analysis cups 4 are stored in the cup feeding mechanism 141, and then the disordered analysis cups 4 are loaded on the slideway 142, and the analysis cup 4 is brought into the cup tray mechanism 143 by the action of gravity, and then grasped by the gripping mechanism 144
- the empty analysis cup 4 is loaded on the node track module 31, so that the batch and orderly output of the analysis cup 4 is realized, and the transportation efficiency of the analysis cup is improved.
- the gripping mechanism 144 drives the gripping structure 1442 to move to an open and closed state through the driving component 1441, so that it can fit with the analysis cup 4 and improve the efficiency of gripping.
- Figure 4a, Figure 4b, and Figure 4c are side and top views of the schematic diagram of the implementation of the above reagent distribution and measurement node 2.
- the reagent distribution and measurement node 2 includes reagent distribution and measurement control Device; connected with the reagent distribution and measurement control device, controlled by the reagent distribution and measurement control device, sucks, transfers, and discharges reagents to the current node analysis cup 4 and performs measurement reagent distribution and measurement devices; reagents
- the distribution and measurement node fixing frame 24 is used to fix each part of the reagent distribution and measurement node to an independent structure.
- the reagent distribution and measurement device further includes a node track module 32, a reagent distribution module 21, a measurement module 23, and an analysis cup transfer module 22.
- the gripping mechanism 221 on the analysis cup transfer module 22 grabs the analysis cup 4 with the sample on the node track 32, and transfers the analysis cup 4 to the incubation module 25 of the reagent distribution and measurement node 2 through the moving mechanism 222; then the reagent is distributed
- the suction and discharge part 211 on the module 21 sucks the analysis reagent from the reagent storage module 26, and the transfer part 212 moves the suction and discharge part 211 to the position of the analysis cup 4 on the incubation module 25, discharges the sucked reagent into the analysis cup 4, and mixes it.
- the mechanism mixes the liquid in the analysis cup 4 uniformly; then the analysis cup 4 containing the reagent and sample liquid mixture is moved into the measurement module 23 by the movement of the gripper mechanism 221, and the sample analysis process is completed in the measurement module 23, and then The analysis cup 4 is transmitted to the next functional node through the node track module 32.
- the above-mentioned gripping mechanism 221 and suction and discharge component 211 include but are not limited to components driven by pneumatic, electric, and hydraulic brakes; the suction and discharge component 211 may be a tube-shaped structure such as a reagent needle and a reagent tube; the suction and discharge component 211 includes but Not limited to, through the movement in the pipeline (a pipeline with multiple ports, that is, one end sucks in the other end to discharge the liquid transfer method), through the reagent needle suction and reagent needle position transfer (the reagent needle is connected with a spatial movement track and a transmission mechanism , That is, the way in which the reagent needle sucks in the reagent, moves the reagent needle in the space to the designated position, and discharges the liquid).
- the movement of the reagent needle can be a plane movement, a rotation with an axis and a certain radius, a plane and a vertical three-dimensional movement, and a rotation with a certain radius and a vertical movement.
- the gripper mechanism 221 may be further connected with a spatial motion mechanism, including but not limited to mechanical structures in the form of motion such as plane motion, vertical motion, three-dimensional motion, and rotational motion, for driving the analysis cup grasped by the gripper mechanism to be transferred to the The distribution of reagents and the measuring position of the measuring node are described.
- the above-mentioned reagent distribution and measurement node further includes a mixing mechanism with a mixing function, which can be specifically capable of driving the liquid mixing movement, including but not limited to mixing methods such as bubbles, stirring, ultrasound, and vibration.
- the above reagent distribution and measurement node further includes a reagent storage module for the storage of analytical reagents.
- the reagent storage structure may further include refrigeration-related components, and the reagent environment in the refrigeration storage structure is at different temperatures Scope, different temperature control levels can be achieved according to the technology known in the industry; the reagent storage module of the reagent distribution and measurement node can coexist in two storage modes of refrigerated storage and non-refrigerated storage to meet the storage of analytical reagents with different characteristics.
- the reagent distribution and measurement node fixing frame 24 is used for fixing the functional components and modules of the reagent distribution and measurement node.
- An independent face shell 241 (refer to FIG. 1b) can also be fixed on the surface of the reagent distribution and measurement node fixing frame 24 to form a relatively independent functional device and facilitate combination with other nodes.
- the track of the node track module 32 includes, but is not limited to, belts, gears, screw rods and other mechanical designs used for transmission.
- the above-mentioned analysis cup 4 is a container made of solid materials.
- the solid materials may include but are not limited to plastic, glass, quartz, metal, etc., which are not easy to break and are convenient for reuse.
- the analysis cup 4 serves as a container for the sample, which can be a single unit or in the form of a continuous cup with several analysis cups connected.
- the measurement module 23 adopts measurement principles including light, electricity, sound, magnetism, etc. Refer to Figures 5-7 for specific detection mechanism examples.
- the sample and reagent in the reaction cup 2321 generate a special light signal after the reaction, and the generated light signal is collected by a photomultiplier tube (PMT) 2322 and converted into a detectable electrical signal, and then used before
- the processing circuit 2323 and the AD acquisition circuit 2324 collect electrical signals and process them in the microcomputer processor 2325 to convert them into displayable data signals.
- the electrical signal generated by the reaction of the sample and the reagent can be collected by 2334, and the signal conditioning circuit 2335 is used to Preliminary processing is performed on the collected electrical signals to adjust the strength of the signal.
- the electrical signal is collected by the AD acquisition circuit 2336, and converted into a displayable data signal in the microcomputer processor 2337.
- a fixed magnetic field is provided by the magnetic rods 2342 and 2343 before and after the reaction book 2341 with a curved track configuration, which triggers the magnetic beads 2344 in the reaction cup 2341 to move back and forth, and at the same time
- the magnetic tank 2345 on one side of the cup generates a magnetic signal after the power is turned on, which can be received by the magnetic tank 2346 on the other side and transmitted through the circuit and converted into an electrical signal.
- the liquid in the reaction cup 2341 is clear, the reciprocating speed of the magnetic beads 2344 is consistent, and the resulting electrical signal is displayed in a regular wave band on the display.
- the solution begins to become turbid, and the resistance of the magnetic beads 2344 during the reciprocating movement becomes greater and the movement speed gradually slows down or even stops, so that the band displayed on the display Start to become smaller until it becomes a straight line, and analyze the concentration of the sample through the change trend of the band.
- Figures 8a, 8b, and 8c are side and top views of the structural schematic diagram of the analysis cup distribution node 5 included in the sample analysis system.
- the analysis cup distribution node 5 can be used to Other nodes of the aforementioned sample analysis system provide analysis cups 4.
- the analysis cup distribution node 5 includes: an analysis cup distribution control device; connected to the analysis cup distribution control device, controlled by the analysis cup distribution control device, and orderly loads the analysis cup onto the analysis cup on the track device Distribution device; analysis cup distribution node fixing frame 52, used to fix each part of the analysis cup distribution node to an independent structure.
- the analysis cup distribution device further includes a second analysis cup distribution module 51 and a node track module 33.
- a large number of analysis cups 4 are stored in the cup feeding mechanism 511 of the second analysis cup distribution module 51, and the disordered analysis cups 4 can be loaded onto the chute 512 (non-bidirectional track) through the cup feeding mechanism 511, and then use gravity
- the function causes the analysis cup 4 to reach the cup tray mechanism 513, and then the empty analysis cup 4 is grabbed by the gripping mechanism 514 and loaded onto the node track module 33.
- An independent face shell 521 can also be fixed on the surface of the fixing frame 52 for fixing the components and modules.
- 9a, 9b, and 9c which are side and top views of a structural diagram of a sample analysis system including an analysis cup distribution node in this embodiment.
- the above sample analysis system can consist of one analysis cup distribution node 5 and one sample distribution node.
- Node 1 and two sample analysis nodes 2 (namely, reagent distribution and measurement node 2) are detachably assembled and spliced through the track device 3.
- the analysis cup distribution node 5 provides a large number of analysis cups 4 to the track 3, and then transmits them through the track 3.
- the analysis cup 4 arrives at the sample distribution node 1, the sample transfer module 11 of the sample analysis node 1 loads the sample in the analysis cup 4, and finally reaches the sample analysis node 2 for measurement and analysis.
- the track device 3 can also be a whole connecting track.
- the analysis cup distribution node 5, the sample distribution node 1 and the reagent distribution and measurement node 2 is assembled on the track device 3 by splicing.
- the gears 35 on both sides of the rail device 3 drive the carrier 34 to transport the analysis cup 4 from the analysis cup distribution node 5 to other nodes.
- the nodes can be removed but the track part of the node is retained without affecting the sample analysis system
- the normal use of the remaining part is convenient for maintenance; the track part and the node can also be disassembled and removed together, and the remaining nodes can be spliced and used through the node track, and new nodes can be added to realize the free combination and high efficiency of the above-mentioned distributed sample analysis system Expansion to form different sample analysis systems.
- a sample analysis system control method is proposed, which is used for the above-mentioned sample analysis system control, and includes the following steps:
- step of performing sample analysis according to the combination rule includes:
- the resource nodes include Sample distribution node, reagent distribution and measurement node, and analysis cup distribution node.
- the combination rules include sample priority rules, speed priority rules, and resource node priority rules.
- the sample analysis is implemented according to the above combination rules, that is, the selected nodes are assembled in the order of sample analysis through the track device to obtain the test path of the sample analysis system, and then each node cooperates with each other to perform sample analysis through orbital motion.
- control flow process of the entire sample analysis system is shown in Figure 11. Different task types are distinguished by the number of tasks, items, and requirements, and then combined with the status of each resource node, the optimal control mode is selected among the three combination rules. Control mode to complete sample analysis tasks. These three modes can select the path and order of the sample running in each node.
- the sample priority control mode will be enabled, that is, nodes and tracks will give priority to loading, unloading, and measuring the vehicle where the priority sample is located; when the number of samples in the task is large, you can select speed priority
- the mode enables nodes, tracks, and vehicles to be allocated to idle nodes with the highest efficiency, avoiding waste of resources and achieving optimal sample allocation and analysis speed; when a small number of samples are measured or different nodes of the measurement system select different measurement items
- the node priority mode is selected, the analysis test of the specified node can be completed, which greatly improves the analysis efficiency.
- the distributed sample analysis system can add multiple sample distribution nodes 1 on the basis of one analysis cup distribution node 5, one sample distribution node 1 and two sample analysis nodes 2.
- Improve sample extraction efficiency it is also possible to continue to add multiple sample analysis nodes 2 with different or the same analysis function to achieve the purpose of efficient analysis of multiple samples or simultaneous analysis of different samples.
- the entire analysis system can freely expand multiple nodes with different or same functions through the extension or splicing of the track.
- a sample analysis method which includes the following steps:
- the analysis cup distribution node distributes the analysis cups on the rail device, and the analysis cup is transported to the sample distribution node through the rail device connected to multiple nodes;
- the reagent distribution and measurement node distributes analysis reagents to the analysis cup, and measures and analyzes the sample and reagent mixture in the analysis cup;
- the analysis cups are distributed to the rail device through at least one analysis cup distribution node, and are transported to at least one sample distribution node with an independent frame structure through the rail, and then the samples are distributed to the analysis cup; a number of reagent distribution and measurement nodes with independent frame structures
- the analysis cup allocates reagents for detection, and these reagent distribution and measurement nodes complete the measurement and analysis of the reagent sample mixture in order; among them, the track connecting each node is used to complete the transfer of the analysis cup between each node and the node Transmission; set up a control system to control the analysis cup distribution node, sample distribution node and reagent distribution and measurement node and track to work together.
- the distributed sample analysis system uses the analysis cup as the medium, adopts relatively independent several nodes with sample distribution function, several relatively independent reagent distribution and measurement nodes and nodes, and controls each of them through the sample analysis system control method.
- the free combination and connection of nodes on the track breaks the restriction of the physical coordination relationship between the sample distribution parts and sample analysis parts of the traditional instrument, and realizes the full automation of small size, high efficiency, high degree of freedom, and high scalability Analysis system; and because the nodes can be freely added, freely combined and connected to form an analysis system with different speeds and analysis functions, it greatly improves the utilization of instrument structural components and is easy to install and maintain.
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Abstract
一种样本分析系统及其控制方法、样本分析方法,所述样本分析系统包括:控制装置;受所述控制装置控制,运载分析杯的轨道装置(3);配置在轨道装置(3)上,向分析杯分配样本的至少一个独立的样本分配节点(1),独立的样本分配节点(1)用于样本的吸取、转移以及排吐;配置在轨道装置(3)上,向分析杯分配检测试剂,并测量分析杯中混合液的至少两个独立的试剂分配及测量节点(2),独立的试剂分配及测量节点(2)用于试剂的吸取、转移、排吐以及试剂和样本混合液的测量。以分析杯为媒介,采用独立的样本分配节点、试剂分配及测量节点以及节点间通过轨道的组合连接,实现了高自由度、高扩展性的全自动化分析系统。
Description
本发明属于自动化分析技术领域,尤其涉及一种样本分析系统及其控制方法、样本分析方法。
样本分析的自动化是当前科学分析、体外诊断行业发展的大趋势,行业内多家企业推出了多个型号自动化分析系统和自动化流水线分析系统。
现有的自动化分析系统一般都包含有样本的吸取、转移、排出等样本分配相关组件和试剂的吸取、转移、排出、孵育、测量等样本分析相关的多种组件,这些组件通过相互制约的结构和空间配合关系协同工作,由一套完成的的样本分配、试剂分配、转移、测量相关的各个模块及组件共同构成了一个独立的分析系统。
这种系统的部件由一整套完成的方案设计而成,组件或模块的拆卸会导致系统无法正常的工作,具有不可分割性,更不具备扩展性。在这种系统中,会导致一定的部件资源被浪费,系统未发挥到最大效率,且无法自由组合和高效率的扩展。
国际专利WO 2016205986A1号中公开了一种的样本分析装置,包含有样本分配、转移和分析等模块一体的独立分析仪。虽然利用多个反应杯缓存装置来不间断提供反应杯而避免人工频繁操作和时间消耗。但在实际应用过程中,只能单独有序的分析不同的样本,分析速度较慢。同时相对独立和完整的分析系统,体积大不利于后续的分析系统的扩展和维修。
商业化的自动化分析系统为了获得更高的分析速度,以流水线式将多个相对独立完整的分析系统以轨道相连。美国专利US2013317773A1、国际专利WO2017/177466A1,公开了两种传送装置,其均为给具备完整功能的独立分析仪提供样本,并未改变分析仪的内部模块间的结构制约关系和效率。
美国专利 US20180313861A1中公开了一种样本分析系统,其输送装置包含有:在两个样本分析装置之间输送容器或容器架的机械臂以及支承机械臂的基台,利用这种输送装置,实质上仍然为样本的传输方案,并未从分析仪层面改善分析仪系统的效率。
以上专利实施的商业化的自动化分析系统流水线,由多个完整功能的独立分析系统的连接,体积庞大,样本分配相关的吸、排、定量、等功能模块,和试剂分配、孵育、测量、混匀等相关模块绑定于分析系统内,结构上相互依存,作为一个合并仪器单位进行布置。而在实际应用过程中,往往孵育、测量功能的相关模块为限速步骤,例如在多数免疫反应过程中单个反应的检测时间到达几分钟到几十分钟的时长,而样本的分配为吸样、转移、排出往往不需要不确定性的反应时间限制,在这种情况下,传统的完整分析系统组合的流水线分析系统方案就会导致大量的样本相关部件资源未发挥到最大效率,导致成本、效率、体积上的浪费,更加无法高效率的扩展。
发明内容
本发明实施例提供一种样本分析系统,旨在解决现有样本分析系统体积庞大、无法自由组合、高效、扩展的问题。
本发明实施例是这样实现的,一种样本分析系统包括:控制装置;受所述控制装置控制,运载分析杯的轨道装置;配置在所述轨道装置上,向分析杯分配样本的至少一个独立的样本分配节点,所述独立的样本分配节点用于样本的吸取、转移以及排吐;配置在所述轨道装置上,向分析杯分配检测试剂,并测量分析杯中混合液的至少两个独立的试剂分配及测量节点,所述独立的试剂分配及测量节点用于试剂的吸取、转移、排吐以及试剂和样本混合液的测量;所述分析杯用于盛装样本、试剂和信号测量。
本发明实施例还提供,所述轨道装置包括与所述样本分配节点及试剂分配及测量节点对应的多段节点轨道,用于联通各个节点,所述多段节点轨道,为一体的同步运动结构或自由拼接组合的分体式结构。
本发明实施例还提供,所述样本分配节点包括:
样本分配控制装置;
受所述样本分配控制装置控制,吸取、转移、排吐样本到位于当前节点分析杯内的样本分配装置。
样本分配节点固定框架,用于将所述样本分配节点的各部分固定到一个独立的结构。
本发明实施例还提供,所述试剂分配及测量节点包括:
试剂分配及测量控制装置;
受所述试剂分配及测量控制装置控制,吸取、转移、排吐试剂到位于当前节点分析杯内并进行测量的试剂分配及测量装置。
试剂分配及测量节点固定框架,用于将所述试剂分配及测量节点的各部分固定到一个独立的结构。
本发明实施例还提供,所述的分析系统具备并行性;
所述分析系统由一个样本分配节点和一个试剂分配及测量节点的组合成基本测量功能;由多于基本测量功能组合的试剂分配及测量节点和样本分配节点构成并行运行节点,
控制系统调配下,在多于基本测量功能组合的试剂分配及测量节点和样本分配节点故障模式下或停止运行模式下,所述的基本测量功能仍然可以实现样本的分析过程。
本发明实施例还提供,所述的分析系统,其特征在于:
所述样本分配节点和试剂分配及测量节点根据不同的组合规则进行组合配置在所述轨道装置上,形成不同的样本分析系统。样本分析系统可通过增加所述的样本分配和试剂分配及测量节点,配置所述的轨道装置,进行扩展。
本发明实施例还提供,所述样本分析系统还包括:
分析杯分配节点,用于向将所述样本分析系统的其他节点提供分析杯。
本发明实施例还提供,所述分析杯分配节点进一步包括:
分析杯分配控制装置;
受所述分析杯分配控制装置控制,将所述分析杯有序加载到所述轨道装置上的分析杯分配装置;
分析杯分配节点固定框架,用于将所述分析杯分配节点的各部分固定到一个独立的结构。
本发明实施例还提供,所述试剂分配及测量节点还包括混匀机构,用于将样本、试剂、以及试剂和样本的混合液混合均匀。
本发明实施例还提供,所述试剂分配及测量节点还包括抓手机构和运动机构,所述抓手机构用于抓取所述轨道上或载具内的所述分析杯,所述运动机构用于带动所述抓手机构抓取的所述分析杯转运到所述试剂分配及测量节点的测量位置。
本发明实施例还提供,所述试剂分配及测量节点还包括试剂存储模块,用于存储分析试剂。
本发明实施例还提供,所述分析杯为由固体材料制成的容器,用来做为样本、试剂的分配、转移、测量的载体。
本发明实施例是这样实现的,一种样本分析系统控制方法,用于所述的样本分析系统的控制,包括以下步骤:
获取任务类型和节点的状态;
根据所述任务类型和节点的状态确定节点的组合规则;
根据所述组合规则实施样本分析。
本发明实施例还提供,所述根据所述组合规则实施样本分析的步骤包括:
根据所述组合规则规划测试路径,包括节点、轨道的选取和组合;
基于所述测试路径执行样本分析。
本发明实施例是这样实现的,一种样本分析方法,用于所述的样本分析系统,包括以下步骤:
由分析杯分配节点向轨道装置上分配分析杯,并将所述分析杯通过连通多个节点的轨道装置运送到样本分配节点;
由所述样本分配节点向所述分析杯中分配样本;
通过所述轨道装置的运动将分析杯运到试剂分配及测量节点;
由试剂分配及测量节点向分析杯分配分析试剂,并对所述分析杯内的样本与试剂的混合液进行测量和分析;
结束分析或重复上述步骤。
由于样本分析系统以分析杯作为媒介,通过采用相对独立的若干个有样本分配功能节点、相对独立的若干个试剂分配及测量节点以及节点间通过轨道的自由组合和连接,打破了传统仪器的样本分配部件、样本分析部件之间的物理配合关系的制约,实现了体积小、高效率、高自由度、高扩展性的全自动化分析系统;且由于节点可以自由的增加、自由组合连接形成不同速度和分析功能的分析系统,大幅度提高仪器结构部件利用率,并且易于安装和维护。
图1a是本发明提供的样本分析系统的侧视结构示意图;
图1b是本发明提供的样本分析系统的另一侧视结构示意图;
图1c是本发明提供的样本分析系统的俯视结构示意图;
图2是本发明提供的样本分析系统的组装与拆卸示意图;
图3a是本发明提供的样本分析系统的样本分配节点1的侧视结构示意图;
图3b是本发明提供的样本分析系统的样本分配节点1的另一侧视结构示意图;
图3c是本发明提供的样本分析系统的样本分配节点1的俯视结构示意图;
图4a是本发明提供的样本分析系统的试剂分配及测量节点2的侧视结构示意图;
图4b是本发明提供的样本分析系统的试剂分配及测量节点2的另一侧视结构示意图;
图4c是本发明提供的样本分析系统的试剂分配及测量节点2的俯视结构示意图;
图5是本发明提供的样本分析系统的测量模块23的一种实施方式;
图6是本发明提供的样本分析系统的测量模块23的另一种实施方式;
图7是本发明提供的样本分析系统的测量模块23的又一种实施方式;
图8a是本发明提供的样本分析系统的样本分析系统的耗材分配节点5的侧视结构示意图;
图8b是本发明提供的样本分析系统的样本分析系统的耗材分配节点5的另一侧视结构示意图;
图8c是本发明提供的样本分析系统的样本分析系统的耗材分配节点5的俯视结构示意图;
图9a是本发明提供的包含分析杯分配节点的样本分析系统的侧视结构示意图;
图9b是本发明提供的包含分析杯分配节点的样本分析系统的另一侧视结构示意图;
图9c是本发明提供的包含分析杯分配节点的样本分析系统的俯视结构示意图;
图10是本发明提供的样本分析系统的轨道装置3为一体结构的俯视结构示意图;
图11是本发明提供的样本分析系统的控制方法的控制过程图;
图12是本发明提供的样本分析系统的节点组合和扩展示意图。
具体实施方式
为了使本发明的目的、技术方案及优点更加清楚明白,以下结合附图及实施例,对本发明进行进一步详细说明。应当理解,此处所描述的具体实施例仅仅用以解释本发明,并不用于限定本发明。
本发明使用可扩展的多个独立的样本分配节点、试剂分配及测量节点并通过受控制装置控制的轨道装置自由组合、拼接成不同的分布式样本分析系统。
为了说明本发明所述的技术方案,下面通过具体实施例来进行说明。
实施例一
如图1a、图1b、图1c所示,图1a、图1b、图1c为上述分布式的样本分析装置的侧视及俯视结构示意图,本发明提出了一种分布式的样本分析系统,包括控制装置;
受所述控制装置控制,运载分析杯的轨道装置3;
配置在所述轨道装置3上,向分析杯分配样本的至少一个独立的样本分配节点1,所述独立的样本分配节点1用于样本的吸取、转移以及排吐;
配置在所述轨道装置3上,向分析杯分配检测试剂,并测量分析杯中混合液的至少两个独立的试剂分配及测量节点2,所述独立的试剂分配及测量节点2用于试剂的吸取、转移、排吐以及试剂和样本混合液的测量;所述分析杯用于盛装样本、试剂和信号测量。
参见图2、图3a、图3b、图3c,图2为上述分布式样本分析系统的组装与拆卸示意图,图3a、图3b、图3c为上述包括分析杯分配模块的样本分配节点1的实施示意图的侧视图及俯视图,上述分布式样本分析系统具体可以由一个包含有分析杯分配模块14的样本分配节点1和两个试剂分配及测量节点2通过轨道3的可拆卸地拼接组合而成,组装与拆卸的方式参见图2所示的A或B;样本分配节点1的分析杯分配模块14提供批量的分析杯4至轨道装置3的节点轨道31上,通过样本分配节点的样本转运模块将样本转移至分析杯4内,随后通过轨道装置3运输至试剂分配及测量节点2的位置,之后在试剂分配及测量节点2完成测定和分析。
上述各个节点是独立的功能单元,并受上述控制装置的控制,例如,当需要移除一个试剂分配及测量节点2时,可以保留节点轨道32部分,因而不影响样本分析系统的正常使用,便于维护;也可以将节点轨道32和试剂分配及测量节点2一起拆卸移除,剩余节点继续拼接使用,还可增加新的节点,进而实现上述样本分析系统的自由组合和高效扩展。
实施例二
上述样本分析系统可以根据组合规则选取多个样本分配节点1和试剂分配及测量节点2,并通过上述控制装置,控制与上述被选取的节点对应的节点轨道,到上述轨道装置3上进行组装从而联通各个节点,或者控制某个节点从上述轨道装置3上拆卸移除,其中轨道装置3包括多段节点轨道,可以为一体的同步运动结构,或者是自由拼接组合的分体式结构。不同的组合规则,可通过增加样本分配节点1和试剂分配及测量节点2,并配置到轨道装置3上进行扩展,从而可以得到不同的样本分析系统。组合规则可以包括速度优先原则、样本优先原则、资源优先原则等。
进一步的,上述样本分析系统具备并行性,即该样本分析系统可以由一个样本分配节点1和一个试剂分配及测量节点2的组合成基本测量功能;由多于基本测量功能组合的试剂分配及测量节点和样本分配节点构成并行运行节点,在控制系统调配下,在多于基本测量功能组合的试剂分配及测量节点2和样本分配节点1故障模式下或停止运行模式下,该样本分析系统的基本测量功能仍然可以实现样本的基本分析过程。例如,在由一个样本分配节点1和一个试剂分配及测量节点2组合成基本测量功能的样本分析系统中,当样本分配节点1的样本分配速度较快时,可以适当地增加试剂分配及测量节点2的数目(如2个),并在控制系统的调配下并行地进行测量,即可以相继给上述多个试剂分配及测量节点2分配样本,同时进行测试,从而提高测试效率;若其中有一个试剂分配及测量节点2发生故障或停止运行,其余的节点仍然可以继续运行从而实现相应的分析。样本分析系统的并行性可以不影响整个系统的正常工作,便于维护和维修。
如图3a、图3b、图3c所示,上述样本分配节点1包括样本分配控制装置;与所述样本分配控制装置连接,受所述样本分配控制装置控制,吸取、转移、排吐样本到位于当前节点分析杯内的样本分配装置;样本分配节点固定框架12,用于将所述样本分配节点的各部分固定到一个独立的结构。
上述样本分配装置进一步包括节点轨道模块31、第一分析杯分配模块14以及样本转运模块11、样本加载区13。
样本转运模块11上的吸排部件111从样本加载区13内的样本架131上的样本管中吸取样本,随后通过轨道112与样本转运模块11的配合,移动吸排部件111至节点轨道模块31上分析杯4所在的位置,并排出样本液体至分析杯4内。
在本实施例中,上述吸排部件111包括但不限于气动、电动、液压制动所驱动的定量液体吸排部件;吸取样本的部件结构1111可以为样本针、样本管等管型结构,可以快速吸取样本。
节点轨道模块31用于分析杯4的传输,分析杯4可直接置于轨道上并与轨道通过固定配合、摩擦力配合、凹凸结构配合等力学驱动方式进行传输,当分析杯4直接置于轨道上时分析杯优选连杯的形式。上述的轨道包括但不限于皮带、齿轮、丝杆等用于传动运动的机械设计形式;在另外一些可能的实施例中,分析杯4置于节点轨道31上的形式可以替换为分析杯4加载到节点轨道31上设置的载具34上,载具34为能够容纳分析杯4的固态结构。
样本分配节点固定框架12用于样本分配节点1集成的各模块及组件的固定,整个样本分配节点1固定有独立的面壳121(参照图1a),以形成一个相对独立的功能结构且便于和其他节点组合。
样本加载区13,作为样本的输入区域,可以方便节点轨道31向其它节点传输样本;样本加载区13为直接人工放置、通过自动运动机构传入(与上述轨道非同一机构)等方式将样本置入加载区,样本可以是直接采血管、手工或自动预先分配至容器的样本。
第一分析杯分配模块14,用于快速的提供分析杯4。在进杯机构141中存放大量的分析杯4,随后将无序的分析杯4加载到滑道142后,利用重力的作用使分析杯4到达杯盘机构143内,随后通过抓手机构144抓取空的分析杯4加载到节点轨道模块31上,从而实现分析杯4批量有序的输出,提高了分析杯的输送效率。
在本实施例中,抓手机构144通过驱动部件1441带动抓手结构1442运动达到开启、闭合状态,从而可以与分析杯4相契合,提高抓取的效率。
如图4a、图4b、图4c所示,图图4a、图4b、图4c为上述试剂分配及测量节点2的实施示意图的侧视及俯视图,试剂分配及测量节点2包括试剂分配及测量控制装置;与所述试剂分配及测量控制装置连接,受所述试剂分配及测量控制装置控制,吸取、转移、排吐试剂到位于当前节点分析杯4内并进行测量的试剂分配及测量装置;试剂分配及测量节点固定框架24,用于将所述试剂分配及测量节点的各部分固定到一个独立的结构。
试剂分配及测量装置进一步包括节点轨道模块32、试剂分配模块21、测量模块23以及分析杯转移模块22。其中,分析杯转移模块22上的抓手机构221抓取节点轨道32上装有样本的分析杯4,通过移动机构222传送分析杯4至试剂分配及测量节点2的孵育模块25内;随后试剂分配模块21上的吸排部件211从试剂存储模块26吸取分析试剂,通过转移部件212移动吸排部件211至孵育模块25上分析杯4所在的位置,排出吸取的试剂至分析杯4内,并使用混匀机构将分析杯4内的液体混合均匀;之后通过抓手机构221的移动将装有试剂和样本液体混合液的分析杯4至测量模块23中,在测量模块23中完成样本的分析过程,然后通过节点轨道模块32将分析杯4传输到下一功能节点。
上述抓手机构221、吸排部件211包括但不限于气动、电动、液压制动所驱动部件;吸排部件211的吸取试剂的结构可以是试剂针、试剂管等管型结构;吸取试剂的结构包括但不限于,通过管路内的移动(具备多口的管路,即一端吸入另一端排出的液体转移方式)、通过试剂针吸取和试剂针位置转移(试剂针连有空间运动的轨道和传动机构,即试剂针吸入试剂,空间移动试剂针到达指定位置,并排出液体的移动方式)。试剂针的运动可以是平面运动、以轴心和一定半径的转动、平面和垂直的三维运动、以轴心和一定半径转动并垂直运动等运动方式。抓手机构221可进一步连接有空间运动机构,包括但不限于平面运动、垂直运动、三维运动、旋转运动等运动形式的机械结构,用于带动抓手机构抓取的所述分析杯转运到所述试剂分配及测量节点的测量位置。
上述试剂分配及测量节点进一步包含有混匀功能的混匀机构,具体可以是能够驱动液体混匀运动的,包括但不限于气泡、搅拌、超声、震动等混匀方式。
上述试剂分配及测量节点进一步包含试剂存储模块,用于分析试剂的存储,在存在生物原料试剂的情况下,试剂存储结构可进一步包含有制冷相关组件,制冷存储结构中的试剂环境在不同的温度范围,根据行业所公知的技术可以做到不同的温度控制水平;试剂分配及测量节点的试剂存储模块可以为制冷存储和不制冷两种存储模式共存来满足不同特征的分析试剂的存储。
试剂分配及测量节点固定框架24,用于试剂分配及测量节点的功能组件和模块的固定。在试剂分配及测量节点固定框架24的表面还可以固定独立的面壳241(参照图1b),配合形成一个相对独立的功能装置且便于和其他节点组合。
上述节点轨道模块32的轨道包括但不限于皮带、齿轮、丝杆等用于传动运动的机械设计形式。
上述的分析杯4为由固体材料制成的容器,固体材料可以是包括但不限于塑料、玻璃、石英、金属等,不容易摔坏且方便重复利用。分析杯4作为样本的容器,可以以单个为单位,也可以是几个分析杯相连的连杯形式。
测量模块23,所采用的的测量原理包括光、电、声、磁等,具体检测机理事例参照图5-7。
例如,采用光检测原理时,如图5中的A部分所示,光源2311发射的光谱通过滤光片2312后,只有特定波长的光到达和透过盛有样本和试剂混合液的反应杯2313,随后通过光电二极管2314收集透过反应杯2313的光信号及转化为电信号,在经过前处理电路2315和AD采集电路2316收集电信号,并在微机处理器2317进行处理,转换成可显示的数据信号。
在图5中的B部分中,反应杯2321中的样本和试剂反应后产生特殊的光信号,通过光电倍增管(PMT)2322收集产生的光信号和转换为可检测的电信号,随后利用前处理电路2323和AD采集电路2324收集电信号,并在微机处理器2325进行处理,转换成可显示的数据信号。
如图6所示,采用电检测原理时,通过在反应杯2331中插入阳电极2332和阴电极2333,随着样本和试剂的反应,产生的电信号可以被2334收集,利用信号调理电路2335对收集的电信号进行初步处理,调整信号的强弱。再通过AD采集电路2336收集电信号,并在微机处理器2337进行转化处理,转换成可显示的数据信号。
例如,采用磁检测原理时参照图7,通过具有弯曲轨道构型的反应本2341前后的磁棒2342和2343提供一个固定的磁场,引发反应杯2341中的磁珠2344进行往返运动,同时在反应杯一侧的磁罐2345接通电源后产生一个磁信号,可以被另一侧的磁罐2346接受并通过电路传输和转换为电信号。当反应杯2341中的液体为澄清时,磁珠2344的往返速度一致,最终形成的电信号在显示器端显示的为有规律的波段。随着反应杯2341中的样本和试剂开始反应,溶液开始浑浊,磁珠2344在进行往返运动时受到的阻力越来越大,运动的速度逐渐变慢甚至停止,以至于在显示器端显示的波段的开始变小直至成一条直线,通过波段的变化趋势对样本的浓度进行分析。
如图8a、图8b、图8c所示,图8a、图8b、图8c为上述样本分析系统包括的分析杯分配节点5的结构示意图的侧视及俯视图,分析杯分配节点5可用于向将上述样本分析系统的其他节点提供分析杯4。分析杯分配节点5包括:分析杯分配控制装置;与所述分析杯分配控制装置连接,受所述分析杯分配控制装置控制,将所述分析杯有序加载到所述轨道装置上的分析杯分配装置;分析杯分配节点固定框架52,用于将所述分析杯分配节点的各部分固定到一个独立的结构。
其中,分析杯分配装置进一步包括第二分析杯分配模块51和节点轨道模块33。在第二分析杯分配模块51的进杯机构511中存放大量的分析杯4,通过进杯机构511可以将无序的分析杯4加载到滑道512(非双向轨道),然后后利用重力的作用使分析杯4到达杯盘机构513内,随后通过抓手机构514抓取空的分析杯4加载到节点轨道模块33上。在用于组件和模块的固定的固定框架52的表面还可以固定独立的面壳521。
参照图9a、图9b、图9c,是本实施例中包含分析杯分配节点的样本分析系统的一个结构图的侧视及俯视图,上述样本分析系统可以由一个分析杯分配节点5、一个样本分配节点1以及两个样本分析节点2(即试剂分配及测量节点2)通过轨道装置3进行可拆卸的组合拼接,分析杯分配节点5向轨道3提供大量的分析杯4,随后通过轨道3的传输,分析杯4到达样本分配节点1,通过样本分析节点1的样本转运模块11在分析杯4内加载样本,最后到达样本分析节点2进行测定分析。
在另外一些可选的实施例中,上述样本分析系统中,轨道装置3还可以是一整条连接轨道,如图10所示,分析杯分配节点5、样本分配节点1以及试剂分配及测量节点2在轨道装置3上进行拼接组合而成。通过轨道装置3两侧的齿轮35带动载具34传输分析杯4从分析杯分配节点5运输至其他节点。
由于上述样本分配节点1、试剂分配及测量节点2、分析杯分配节点5都是具有独立框架结构的功能单元,通过不同的组合规则,可以移除节点但保留节点轨道部分而不影响样本分析系统剩余部分的正常使用,便于维护;也可以将轨道部分和节点一起拆卸移除,剩余节点通过节点轨道进行拼接使用,还可增加新的节点,从而实现上述分布式样本分析系统的自由组合和高效扩展,形成不同的样本分析系统。
实施例三
作为本发明的另一种实施方案,提出了一种样本分析系统控制方法,用于上述样本分析系统的控制,包括以下步骤:
获取任务类型和节点的状态;
根据所述任务类型和节点的状态确定节点的组合规则;
根据所述组合规则实施样本分析。
进一步的,所述根据所述组合规则实施样本分析的步骤包括:
根据所述组合规则规划测试路径,包括节点、轨道的选取和组合;
基于所述测试路径执行样本分析。
首先,获取输入上述样本分析系统的任务类型,包括任务数目、任务项目、任务要求;同时获取上述样本分析系统的资源节点的状态,即资源节点的使用情况、是否存在异常资源等,资源节点包括样本分配节点、试剂分配及测量节点以及分析杯分配节点。
接着根据上述获取到的任务类型和资源节点的状态确定组合规则,即根据任务类型选择节点类型和数量,然后根据资源节点的状态,选取未有异常的、未被占用的节点,以满足任务的需求。组合规则包括样本优先规则、速度优先规则、资源节点优先规则。
最后根据上述组合规则实施样本分析,即将选中的节点通过轨道装置按样本分析的顺序进行组装,从而得到样本分析系统的测试路径,然后各节点通过轨道运动来相互配合进行样本分析。
整个样本分析系统控制流过程如图11所示,通过任务的数目、项目以及要求来区分不同的任务类型,随后结合各个资源节点的状态,在三种组合规则对应的控制模式中选择最优的控制模式来完成样本分析任务。这三种模式都可以选择样本在各个节点中运行的路径和顺序。比如,任务类型为急诊任务,会启用样本优先的控制模式,即节点、轨道都会优先对优先样本所处的载具进行装载、卸载、测量;而任务的样本数目较大时,可以选择速度优先模式,使得节点、轨道、载具以最高的效率分配到闲置的节点,避免资源的浪费从而达到最优的样本分配和分析速度;而当少量样本测量或测量系统不同的节点选取了不同测量项目时,优选节点优先模式,这样可以完成指定节点的分析测试,大大提高了分析效率。
此外,由于上述样本分析系统具有高自由度和高扩展性,通过上述样本分析系统控制方法可以控制多个样本分配节点1、样本分析节点2以及分析杯分配节点5通过轨道3进行自由拼接形成分布式结构,例如,如图12所示,分布式样本分析系统可以在一个分析杯分配节点5、一个样本分配节点1和两个样本分析节点2的基础上,增加多个样本分配节点1,来提高样本的提取效率;也可以继续增加多个不同或相同分析功能的样本分析节点2,以实现多个样本高效分析或不同样本的同时分析目的。整个分析系统通过轨道的延长或拼接可以自由扩展多个不同或相同功能的节点。通过上述样本分析系统控制方法控制上述样本分析系统的样本分配节点和试剂分配及测量节点的数量及组合方式,以及通过结合和连接的形式调整呈现的多种协调工作方式,均属于基于本方案的变化范畴。
实施例四
作为本发明的另一种实施方案,提出了一种样本分析方法,包括以下步骤:
由分析杯分配节点向轨道装置上分配分析杯,并将所述分析杯通过连通多个节点的轨道装置运送到样本分配节点;
由所述样本分配节点向所述分析杯中分配样本;
通过所述轨道装置的运动将分析杯运到试剂分配及测量节点;
由试剂分配及测量节点向分析杯分配分析试剂,并对所述分析杯内的样本与试剂的混合液进行测量和分析;
结束分析或重复上述步骤。
通过至少一个分析杯分配节点向轨道装置上分配分析杯,并通过轨道运输到至少一个具有独立框架结构的样本分配节点然后向分析杯分配样本;由若干具有独立框架结构的试剂分配及测量节点向分析杯分配用于检测的试剂,并由这些试剂分配及测量节点按顺序完成试剂样本混合液的测量与分析;其中,连通各个节点的轨道,用来完成分析杯在各个节点的转运和节点间的传输;设置一控制系统,用来控制分析杯分配节点、样本分配节点和试剂分配及测量节点和轨道协同工作。
本发明提供的分布式样本分析系统以分析杯作为媒介,通过采用相对独立的若干个有样本分配功能节点、相对独立的若干个试剂分配及测量节点以及节点,并通过样本分析系统控制方法控制各个节点间在轨道上的自由组合和连接,打破了传统仪器的样本分配部件、样本分析部件之间的物理配合关系的制约,实现了体积小、高效率、高自由度、高扩展性的全自动化分析系统;且由于节点可以自由的增加、自由组合连接形成不同速度和分析功能的分析系统,大幅度提高仪器结构部件利用率,并且易于安装和维护。
以上所述仅为本发明的较佳实施例而已,并不用以限制本发明,凡在本发明的精神和原则之内所作的任何修改、等同替换和改进等,均应包含在本发明的保护范围之内。
Claims (15)
- 一种样本分析系统,其特征在于,包括:控制装置;受所述控制装置控制,运载分析杯的轨道装置;配置在所述轨道装置上,向分析杯分配样本的至少一个独立的样本分配节点,所述独立的样本分配节点用于样本的吸取、转移以及排吐;配置在所述轨道装置上,向分析杯分配检测试剂,并测量分析杯中混合液的至少两个独立的试剂分配及测量节点,所述独立的试剂分配及测量节点用于试剂的吸取、转移、排吐以及试剂和样本混合液的测量;所述分析杯用于盛装样本、试剂和信号测量。
- 如权利要求1所述的样本分析系统,其特征在于,所述轨道装置包括与所述样本分配节点及试剂分配及测量节点对应的多段节点轨道,用于联通各个节点,所述多段节点轨道,为一体的同步运动结构或自由拼接组合的分体式结构。
- 如权利要求2所述的样本分析系统,其特征在于,所述样本分配节点包括:样本分配控制装置;受所述样本分配控制装置控制,吸取、转移、排吐样本到位于当前节点分析杯内的样本分配装置;样本分配节点固定框架,用于将所述样本分配节点的各部分固定到一个独立的结构。
- 如权利要求3所述的样本分析系统,其特征在于,所述试剂分配及测量节点包括:试剂分配及测量控制装置;受所述试剂分配及测量控制装置控制,吸取、转移、排吐试剂到位于当前节点分析杯内并进行测量的试剂分配及测量装置;试剂分配及测量节点固定框架,用于将所述试剂分配及测量节点的各部分固定到一个独立的结构。
- 权利要求4所述样本分析系统,其特征在于,所述分析系统具备并行性:所述分析系统由一个样本分配节点和一个试剂分配及测量节点的组合成基本测量功能;由多于基本测量功能组合的试剂分配及测量节点和样本分配节点构成并行运行节点;所述控制系统调配下,在多于基本测量功能组合的试剂分配及测量节点和样本分配节点故障模式下或停止运行模式下,所述的基本测量功能仍然可以实现样本的分析过程。
- 权利要求5所述的样本分析系统,其特征在于,将所述样本分配节点和试剂分配及测量节点根据不同的组合规则进行组合配置在所述轨道装置上,形成不同的样本分析系统。样本分析系统可通过增加所述的样本分配和试剂分配及测量节点,配置所述的轨道装置,进行扩展。
- 如权利要求6所述的样本分析系统,其特征在于,所述样本分析系统还包括:分析杯分配节点,用于向将所述样本分析系统的其他节点提供分析杯。
- 如权利要求7所述的样本分析系统,其特征在于,所述分析杯分配节点进一步包括:分析杯分配控制装置;受所述分析杯分配控制装置控制,将所述分析杯有序加载到所述轨道装置上的分析杯分配装置;分析杯分配节点固定框架,用于将所述分析杯分配节点的各部分固定到一个独立的结构。
- 如权利要求4所述的样本分析系统,其特征在于,所述试剂分配及测量节点还包括混匀机构,用于将样本、试剂、以及试剂和样本的混合液混合均匀。
- 如权利要求9所述的样本分析系统,其特征在于,所述试剂分配及测量节点还包括抓手机构和运动机构,所述抓手机构用于抓取所述轨道上或载具内的所述分析杯,所述运动机构用于带动所述抓手机构抓取的所述分析杯转运到所述试剂分配及测量节点的测量位置。
- 如权利要求10所述的样本分析系统,其特征在于,所述试剂分配及测量节点还包括试剂存储模块,用于存储分析试剂。
- 如权利要求1所述的样本分析系统,其特征在于,所述分析杯为由固体材料制成的容器,用来做为样本和试剂的分配、转移、测量的载体。
- 一种样本分析系统控制方法,用于如权利要求1至12任一项所述的样本分析系统的控制,其特征在于,包括以下步骤:获取任务类型和节点的状态;根据所述任务类型和节点的状态确定节点的组合规则;根据所述组合规则实施样本分析。
- 如权利要求13所述的样本分析系统控制方法,其特征在于,所述根据所述组合规则实施样本分析的步骤包括:根据所述组合规则规划测试路径,包括节点、轨道的选取和组合;基于所述测试路径执行样本分析。
- 一种样本分析方法,用于如权利要求1至12任一项所述的样本分析系统,其特征在于,包括以下步骤:由分析杯分配节点向轨道装置上分配分析杯,并将所述分析杯通过连通多个节点的轨道装置运送到样本分配节点;由所述样本分配节点向所述分析杯中分配样本;通过所述轨道装置的运动将分析杯运到试剂分配及测量节点;由试剂分配及测量节点向分析杯分配分析试剂,并对所述分析杯内的样本与试剂的混合液进行测量和分析;结束分析或重复上述步骤。
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Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002048800A (ja) * | 2000-07-31 | 2002-02-15 | Olympus Optical Co Ltd | 自動分析装置 |
US6444171B1 (en) * | 1998-07-31 | 2002-09-03 | Hitachi, Ltd. | Sample processing system |
CN101065670A (zh) * | 2004-11-25 | 2007-10-31 | 霍夫曼-拉罗奇有限公司 | 样本分析装置 |
US20130317773A1 (en) | 2011-02-03 | 2013-11-28 | Sysmex Corporation | Specimen analysis system, specimen analyzer, and specimen analysis method |
CN103460055A (zh) * | 2011-03-30 | 2013-12-18 | 希森美康株式会社 | 样本分析系统及样本分析装置 |
CN103733071A (zh) * | 2011-08-01 | 2014-04-16 | 株式会社日立高新技术 | 遗传测试系统 |
WO2016205986A1 (zh) | 2015-06-22 | 2016-12-29 | 深圳迈瑞生物医疗电子股份有限公司 | 样本分析装置及其控制方法 |
WO2017177466A1 (zh) | 2016-04-15 | 2017-10-19 | 深圳迈瑞生物医疗电子股份有限公司 | 样本架运输装置、样本分析设备及样本分析系统 |
US20180313861A1 (en) | 2017-04-28 | 2018-11-01 | Sysmex Corporation | Transporting apparatus, transporting method, and sample analysis system |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3175729B2 (ja) * | 1999-03-10 | 2001-06-11 | 株式会社日立製作所 | 自動分析装置 |
US6808304B2 (en) * | 2002-08-27 | 2004-10-26 | Dade Behring Inc. | Method for mixing liquid samples using a linear oscillation stroke |
ATE400817T1 (de) * | 2004-03-31 | 2008-07-15 | Hoffmann La Roche | Modulare analysevorrichtung |
JP5372678B2 (ja) * | 2009-09-17 | 2013-12-18 | シスメックス株式会社 | 検体処理装置 |
US9039992B2 (en) * | 2011-06-06 | 2015-05-26 | Abbott Laboratories | Apparatus for closed tube sampling and open tube sampling for automated clinical analyzers |
EP2755037A4 (en) * | 2011-09-05 | 2015-04-08 | Hitachi High Tech Corp | AUTOMATIC ANALYSIS DEVICE |
US20140107953A1 (en) * | 2012-10-16 | 2014-04-17 | Beckman Coulter, Inc. | Container fill level detection |
EP2943116B1 (en) * | 2013-01-09 | 2021-06-23 | Siemens Healthcare Diagnostics Inc. | Throughput optimizing reagent distribution |
WO2015126839A1 (en) * | 2014-02-19 | 2015-08-27 | Siemens Healthcare Diagnostics Inc. | Mother daughter tube carrier for aliquoters |
WO2016130962A1 (en) * | 2015-02-13 | 2016-08-18 | Abbott Laboratories | Automated storage modules for diagnostic analyzer liquids and related systems and methods |
JP2019506619A (ja) * | 2015-12-18 | 2019-03-07 | アボット ラボラトリーズ | 自動化分析のためのシステムおよび方法 |
JP6850545B2 (ja) * | 2016-03-31 | 2021-03-31 | シスメックス株式会社 | 検体分析システム |
CN105974894B (zh) * | 2016-04-25 | 2018-05-29 | 温冬梅 | 一种医疗实验室自动化流水线的试剂自动补给系统 |
LU100530B1 (en) * | 2017-11-29 | 2019-06-12 | Stratec Biomedical Ag | Diagnostic analyzer systems |
-
2019
- 2019-06-06 CN CN201910490798.5A patent/CN110208554B/zh active Active
- 2019-06-14 EP EP19931868.4A patent/EP3916395B1/en active Active
- 2019-06-14 WO PCT/CN2019/091379 patent/WO2020243988A1/zh unknown
-
2021
- 2021-04-26 US US17/241,034 patent/US12007401B2/en active Active
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6444171B1 (en) * | 1998-07-31 | 2002-09-03 | Hitachi, Ltd. | Sample processing system |
JP2002048800A (ja) * | 2000-07-31 | 2002-02-15 | Olympus Optical Co Ltd | 自動分析装置 |
CN101065670A (zh) * | 2004-11-25 | 2007-10-31 | 霍夫曼-拉罗奇有限公司 | 样本分析装置 |
US20130317773A1 (en) | 2011-02-03 | 2013-11-28 | Sysmex Corporation | Specimen analysis system, specimen analyzer, and specimen analysis method |
CN103460055A (zh) * | 2011-03-30 | 2013-12-18 | 希森美康株式会社 | 样本分析系统及样本分析装置 |
CN103733071A (zh) * | 2011-08-01 | 2014-04-16 | 株式会社日立高新技术 | 遗传测试系统 |
WO2016205986A1 (zh) | 2015-06-22 | 2016-12-29 | 深圳迈瑞生物医疗电子股份有限公司 | 样本分析装置及其控制方法 |
WO2017177466A1 (zh) | 2016-04-15 | 2017-10-19 | 深圳迈瑞生物医疗电子股份有限公司 | 样本架运输装置、样本分析设备及样本分析系统 |
US20180313861A1 (en) | 2017-04-28 | 2018-11-01 | Sysmex Corporation | Transporting apparatus, transporting method, and sample analysis system |
Non-Patent Citations (1)
Title |
---|
See also references of EP3916395A4 |
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