WO2020171352A1 - Composition cosmétique comprenant un extrait de portulaca oleracea et de l'acide octadécadiénoïque très pur - Google Patents

Composition cosmétique comprenant un extrait de portulaca oleracea et de l'acide octadécadiénoïque très pur Download PDF

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Publication number
WO2020171352A1
WO2020171352A1 PCT/KR2019/016564 KR2019016564W WO2020171352A1 WO 2020171352 A1 WO2020171352 A1 WO 2020171352A1 KR 2019016564 W KR2019016564 W KR 2019016564W WO 2020171352 A1 WO2020171352 A1 WO 2020171352A1
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WIPO (PCT)
Prior art keywords
cosmetic composition
octadecadienoic acid
purslane extract
mixture
purslane
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PCT/KR2019/016564
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English (en)
Korean (ko)
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이훈민
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이훈민
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine

Definitions

  • the present invention relates to a cosmetic composition comprising purslane extract and high purity octadecadienoic acid. More specifically, the present invention relates to a cosmetic composition capable of penetrating into the stratum corneum and exhibiting excellent moisture and skin elasticity.
  • Skin is largely divided into three layers: epidermis, dermis, and subcutaneous tissue in order from the outside, and has the function of protecting from temperature and humidity changes, ultraviolet rays, and other physical and chemical stimuli of the external environment.
  • the epidermis plays an important role in preventing water evaporation inside the human body.
  • the epidermis is divided into stratum corneum, granule layer, play layer, and basal layer in order from the outside, and the cells in the stratum corneum play a role like bricks, and the intercellular lipids between the keratinocytes act like mortar to form the skin barrier.
  • a high concentration of natural moisturing factor (NMF) is present in the keratinocytes of a healthy person, and it binds with moisture to inhibit moisture from drying out of the skin.
  • NMF natural moisturing factor
  • octadecadienoic acid has previously been introduced and used in cosmetic ingredients, there is a problem that the substance itself is unstable and exists as an oily liquid at room temperature, so it is not suitable for cosmetic formulations due to poor dispersibility in an aqueous cosmetic solution. . Therefore, most of them are sold on the market in the form of capsule pills or functional foods, and even if they are introduced into cosmetics, it is essential to use chemically synthesized surfactants and organic solvents (eg dipropylene glycol) that are controversial to human health, and octadecadienoic acid The content of is also very low situation.
  • organic solvents eg dipropylene glycol
  • Korean Patent Application Publication No. 10-2009-0055948 has attempted a method of obtaining a powder form by nano-encapsulating octadecadienoic acid in an inorganic carrier and then mixing it into a cosmetic formulation, but nano-encapsulation and powder Since Hwara has to involve a complex process, it is difficult to control the process and it is disadvantageous to be applied to the cosmetic industry in terms of cost.
  • the present inventors have tried to provide a cosmetic composition manufacturing technology that contains high-purity octadecadienoic acid, does not have layer separation, penetrates into the stratum corneum, and can exhibit excellent moisture and skin elasticity.
  • high-purity octadecadienoic acid is mixed with a natural purslane extract, and the two substances are completely mixed in a single phase without layer separation without organic solvents and surfactants, making it suitable for cosmetic formulations as well as octadecadienoic acid or
  • the purslane extract exhibited remarkably superior efficacy than when used alone, the present invention was completed.
  • an object of the present invention is to provide a cosmetic composition comprising a mixture of purslane extract and high purity octadecadienoic acid.
  • Another object of the present invention is to provide a method for preparing the cosmetic composition.
  • Another object of the present invention is to provide a cosmetic comprising the cosmetic composition.
  • One aspect of the present invention is to provide a cosmetic composition
  • a cosmetic composition comprising a mixture of purslane extract and high purity octadecadienoic acid having a purity of 70% (w/w) or more.
  • purslane is Portulaca Oleracea , and it is a one-year weed in the family Purslane. It is also called as five-year-old weeds, Jangmyeongchae, Machichae, and Machihyeon. It grows wild in the garden, and the stem is about 15 ⁇ 30cm high, without hair, and the stem is brownish red, and the branches are split a lot and spread obliquely above the ground. The root is white, but if you sweep it with your hand, it turns red like a main stem. Purslane is mixed with seasoning and is edible or used as a medicinal material.
  • omega 3 fatty acids to suppress the onset of ADHD, autism, stroke, and cardiovascular disease, and it has a very high content of vitamin A, a powerful natural antioxidant, to protect skin and mucous membranes. It is excellent in preventing lung cancer and oral cancer by inhibiting mutant cells, and has been recognized for its gastrointestinal protection effect. In addition, due to the iron and copper content, oxygen supply is facilitated and damaged cells are recovered quickly.
  • Purslane is a plant that grows in all areas of Korea, especially in fields rather than paddy fields, and can be easily cultivated. As a hydrophilic crop, it is vulnerable to pesticides, so you need to be careful about external pollution.
  • the purslane extract used as a mixed raw material in the present invention is a hydrophilic component, and may be a fermented purslane extract or a water extract of purslane.
  • the fermented purslane extract may be an extract obtained by mixing purslane with sugar and fermenting the fermented purslane fermented extract by mixing purslane with sugar; And it may be prepared by a method comprising the step of obtaining only a liquid by filtering the fermented product.
  • the purslane extract may be an enzymatic liquid (only a slightly clear liquid with a sediment settling down and floating on the top is used) that has undergone an aging process of 50 to 150 days, preferably about 100 days, and the main ingredient
  • it may also be prepared by fermenting one or more natural plant ingredients such as dandelion, plum, loofah, bamboo shoots and pine needles with sugar and one or more natural plant ingredients beneficial to other skin.
  • Purslane extract prepared as described above contains octadecadienoic acid (fatty acid), but the amount is not large (about 35% or less), so high-purity octadecadienoic acid is mixed with purslane extract to be re-inserted from the outside.
  • the second mixed raw material, octadecadienoic acid is an unsaturated fatty acid having two double bonds, linoleic acid, cis-9-cis-12-octadecadienoic acid, trans-9-trans-12-octadeca Dienoic acid and cis-9-trans-11-octadecadienoic acid.
  • Octadecadienoic acid is a glyceride and is contained in many vegetable oils such as cottonseed oil and corn oil. It is obtained by repeating purification after removing solid fatty acids from mixed fatty acids in vegetable oils. Most of them are present in dry oil, especially linseed oil contains 35 to 50%. Generally, it is not found in animal oil, but it is present in 0.4 to 13% in fish oil.
  • fatty acids such as linseed oil
  • organic solvents such as acetone and using adsorption chromatography.
  • linoleic acid When linoleic acid is brominated, it becomes hexabromide. Oxidation with alkaline permanganic acid results in hexahydroxystearic acid, and hydrogenation can produce stearic acid. Together with linoleic acid, it is an essential fatty acid called vitamin F.
  • Octadecadienoic acid is a colorless oily liquid with a melting point of -12°C and a boiling point of 230°C (16 torr). Since octadecadienoic acid is easily oxidized in air and hardens, it is also called xerophilic acid, and when reduced, it becomes stearic acid.
  • the octadecadienoic acid used in the composition of the present invention may be a high-purity fatty acid having a purity of 70% (w/w) or more, preferably, a purity of 75%, 80%, 85%, or 90% or more, most preferably 95% purity. You can use the above.
  • High-purity octadecadienoic acid can be prepared by extraction and purification processes or can be purchased commercially.
  • 95% pure linoleic acid sold by Hefei TNJ Chemical Industry Co., Ltd in China, and 80 purity sold by Facebook.com. % Or 95% pure linoleic acid, or the brand name Allmax Nutrition CLA 95 can also be purchased and used.
  • the two raw material mixture of the present invention is 20 to 40% by weight of the purslane extract, preferably 25 to 35% by weight; And 60 to 80% by weight, preferably 65 to 75% by weight of high purity octadecadienoic acid.
  • the most preferable mixing ratio is the ratio of 30% of purslane extract and 70% of octadecadienoic acid, and even if the ratio of purslane extract increases, it does not decompose octadecadienoic acid more quickly, and the ratio of purslane extract 30% is the most stable decomposition of linoleic acid. Confirmed.
  • high-purity octadecadienoic acid has a property that the substance itself is unstable and has poor dispersibility in aqueous cosmetics.
  • a cosmetic composition containing a large amount of% (w/w) or more high-purity fatty acids, in particular, a cosmetic composition of a hydration formulation has not been provided.
  • the present invention provides for the first time a cosmetic composition comprising a large amount of a high-purity fatty acid having a purity of 70% (w/w) or more in an amount of 60 to 80% by weight.
  • the composition may be a hydrating formulation selected from mist, serum, nutritional lotion, softening lotion, softening water, emulsion, astrigent, toner, skin, lotion, water gel, solution, foam, spray, etc., but is not limited thereto.
  • the mixture of the present invention mixes the two raw materials, and it is at a temperature of 20 to 40° C. for 5 days to 10 weeks, preferably at a temperature of 37 to 39° C. (most preferably at a temperature of 38° C.), It may be prepared by aging for 7 days to 4 weeks (most preferably for about 8 days).
  • the temperature should be maintained at 20°C ⁇ 40°C. If the temperature exceeds 41°C, all microorganisms die, and thus no further fermentation effect is seen. If it is set lower than the most optimal temperature of 38°C and then mixed, it takes about 4 weeks or more to mix the two mixtures.
  • the above mixing has disadvantages of each component, for example, that high purity octadecadienoic acid is easily oxidized in the air, because it is an oily liquid, it is incompatible with water, which is the main ingredient of cosmetics, and layer separation occurs, and due to oiliness, there is a lot of stickiness when applied to the skin. It can solve problems such as poor spreadability and splitting of vegetable extracts into water and sediment.
  • the mixture of purslane extract and high purity octadecadienoic acid of the present invention is characterized in that it does not contain organic solvents and surfactants.
  • the organic solvent includes a petroleum solvent, benzene, toluene, various alcohol solvents, glycols, thinners, halogenated hydrocarbons, ethers, ketone solvents, hydrogen fluoride, and the like, but is not limited thereto.
  • the surfactant When exposed to humans for a long period of time, the surfactant may cause skin irritation, decreased immunity, rhinitis, asthma, and atopy.Synthetic surfactants mainly used in cosmetics, especially petrochemical surfactants, easily penetrate the skin and penetrate the heart, liver, and It has been reported to be potentially toxic by staying in the body for 5 days while maintaining a certain level in the lungs and brain.
  • Another aspect of the present invention is to provide a cosmetic product made of a cosmetic composition comprising a mixture of purslane extract and high purity octadecadienoic acid as described above.
  • the cosmetics are mist, serum, nutrient lotion, softening lotion, softening water, emulsion, astrigent, toner, skin, lotion, cream, foam, makeup base, essence, liquid cleaning agent, bath agent, sunscreen cream, sun oil, suspension, It may be selected from the group consisting of emulsions, pastes, gels, powders, oils, powder foundations, emulsion foundations, wax foundations, patches, spray products, packs, and hair products, but is not limited thereto.
  • the cosmetic products include moisturizers, thickeners, powders, alcohols, natural polymers, synthetic polymers, sugars, antioxidants within the scope not impairing the effects of the present invention.
  • Buffers, various extracts, stabilizers, preservatives, pigments, or perfumes, etc. are appropriately blended and prepared according to a conventional method.
  • the cosmetic composition of the present invention can be used in cosmetics without rancidity and penetrates to the stratum corneum more than 1.5 times as compared to the conventional purslane extract, resulting in high moisture, excellent skin soothing effect and wrinkle reduction effect, and excellent application properties.
  • Example 1 is a photograph of a mixture of purslane extract and octadecadienoic acid prepared in Example 1.
  • the phase is separated into two layers (the upper layer is octadecadienoic acid and the lower layer is purslane extract), but it can be confirmed that the two layers are finally completely mixed.
  • Figure 2 is a photograph taken when shaking the mixture of purslane extract and octadecadienoic acid prepared in Example 1.
  • the cleansed purslane and sugar were put in a jar at a weight ratio of 1:1, and the mouth was sealed with a cloth through which air was passed, so that microorganisms in the air were naturally contaminated. After 2 days, the mixture was stirred until all the sugar on the bottom was dissolved and turned over. When all of the moisture was drained from the stem and the stem emerged, the stem was pressed with a stone to immerse it in the undiluted solution, and the jar was sealed. After aging for 100 days from sealing, the sediment settled below was filtered off, and only the clear liquid floating above was obtained.
  • the prepared purslane extract was confirmed to contain octadecadienoic acid, but the amount was not large, so to put it back outside, it was mixed with 95% pure octadecadienoic acid (Hefei TNJ Chemical Industry Co., Ltd).
  • the mixing ratio was such that the weight ratio of purslane to octadecadiene was 3:7.
  • the phase is separated into two layers (the upper layer is octadecadienoic acid and the lower layer is purslane extract), but when mixing while maintaining the temperature of 20°C ⁇ 40°C, the fermentation effect of purslane enzyme It was confirmed that the layers could finally be thoroughly mixed.
  • the temperature exceeded 41°C, all the microorganisms were killed and no further fermentation effect was seen.
  • the optimum temperature by raising the temperature from 20°C to 1°C, the two substances were completely mixed after about 8 days at 38°C (190-192 hours in total). If it was set lower than 38°C and mixed, it took about 4 weeks or more for the two materials to be completely mixed. In the end, it was confirmed that the two substances were properly mixed in a cosmetic formulation, and the optimum temperature was 38°C and the time required 8 days.
  • a cosmetic composition was prepared in which the purslane extract and octadecadienoic acid were mixed in the same manner as in Example 1, except that the purslane hot water extract was used as the purslane extract.
  • Purslane hot water extract was prepared by heating the cleansed purslane for 1 hour in a pressure cooker at 90° C., compressing, extracting, filtering, and centrifuging the obtained supernatant for 5 minutes at a speed of 4000 rpm to obtain a purslane hot water extract.
  • Purslane fermented extract (purslane enzyme stock solution) prepared as described above was found to contain about 35% of octadecadienoic acid, although the amount is not large. Accordingly, a fermented purslane extract to which octadecadienoic acid of 95% purity was not added was used as Comparative Example 1.
  • Example 1 Example 2 Comparative Example 1 Comparative Example 2 Moisturizing power 6.9 6.0 4.0 4.7 Eye wrinkle improvement 5.5 5.4 4.1 4.5 Skin soothing effect 6.7 6.1 4.2 3.5 Spreadability 6.8 6.2 5.3 2.7
  • the moisturizing power of the mist using the compositions of Examples 1 to 2 was excellent.In particular, in the case of Example 1, it penetrated to the stratum corneum by 1.5 times or more compared to Comparative Example 1 containing only purslane extract, showing high moisture sensation and superior moisturizing power. Confirmed. In addition, as a result of consistent use of the mist containing the compositions of Examples 1 to 2, not only the dry skin was improved a lot, but also the wrinkles around the eyes were slightly lightened, and there was no skin irritation and the moist and itchy skin was also relieved, so that the skin soothing effect was excellent. Confirmed.

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Abstract

La présente invention concerne une composition cosmétique comprenant un mélange d'un extrait de Portulaca oleracea et d'acide octadétadiénoïque. La composition cosmétique de la présente invention peut être utilisée en cosmétique sans devenir rance, fournit une sensation d'hydratation remarquablement élevée, présente d'excellents effets apaisants et de réduction des rides sur la peau, et peut être étalée aisément sur la peau, en comparaison avec les extraits de Portulaca oleracea classiques.
PCT/KR2019/016564 2019-02-22 2019-11-28 Composition cosmétique comprenant un extrait de portulaca oleracea et de l'acide octadécadiénoïque très pur WO2020171352A1 (fr)

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KR1020190021250A KR102030310B1 (ko) 2019-02-22 2019-02-22 쇠비름 추출물 및 고순도 옥타데카디엔산을 포함하는 화장료 조성물
KR10-2019-0021250 2019-02-22

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114869816A (zh) * 2022-05-09 2022-08-09 惠州腾大健康科技有限公司 一种马齿苋提取物组合物

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102030310B1 (ko) * 2019-02-22 2019-10-08 이훈민 쇠비름 추출물 및 고순도 옥타데카디엔산을 포함하는 화장료 조성물

Citations (5)

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Publication number Priority date Publication date Assignee Title
KR20000046633A (ko) * 1998-12-31 2000-07-25 성재갑 아토피성 피부염 치유용 조성물
KR20050048287A (ko) * 2003-11-19 2005-05-24 주식회사 쟌퀼 아토피성 피부염을 개선을 위한 화장품 조성물
KR20090055948A (ko) * 2007-11-29 2009-06-03 (주)나노하이브리드 불포화 지방산 및 층상형 금속 수산화물의 혼성체, 그 제조방법, 및 그 혼성체를 포함하는 기능성 식품 및 피부외용제
KR20150018057A (ko) * 2013-08-09 2015-02-23 이한샘 식물성 피부 영양 보습제 및 이의 제조방법
KR102030310B1 (ko) * 2019-02-22 2019-10-08 이훈민 쇠비름 추출물 및 고순도 옥타데카디엔산을 포함하는 화장료 조성물

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000046633A (ko) * 1998-12-31 2000-07-25 성재갑 아토피성 피부염 치유용 조성물
KR20050048287A (ko) * 2003-11-19 2005-05-24 주식회사 쟌퀼 아토피성 피부염을 개선을 위한 화장품 조성물
KR20090055948A (ko) * 2007-11-29 2009-06-03 (주)나노하이브리드 불포화 지방산 및 층상형 금속 수산화물의 혼성체, 그 제조방법, 및 그 혼성체를 포함하는 기능성 식품 및 피부외용제
KR20150018057A (ko) * 2013-08-09 2015-02-23 이한샘 식물성 피부 영양 보습제 및 이의 제조방법
KR102030310B1 (ko) * 2019-02-22 2019-10-08 이훈민 쇠비름 추출물 및 고순도 옥타데카디엔산을 포함하는 화장료 조성물

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114869816A (zh) * 2022-05-09 2022-08-09 惠州腾大健康科技有限公司 一种马齿苋提取物组合物

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