WO2020133136A1 - 一种治疗阴道炎的导管药物型卫生栓及其制备方法 - Google Patents

一种治疗阴道炎的导管药物型卫生栓及其制备方法 Download PDF

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Publication number
WO2020133136A1
WO2020133136A1 PCT/CN2018/124608 CN2018124608W WO2020133136A1 WO 2020133136 A1 WO2020133136 A1 WO 2020133136A1 CN 2018124608 W CN2018124608 W CN 2018124608W WO 2020133136 A1 WO2020133136 A1 WO 2020133136A1
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tampon
outer tube
parts
chinese medicine
inner tube
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PCT/CN2018/124608
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English (en)
French (fr)
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赵春梅
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赵春梅
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Priority to ZA2020/03574A priority Critical patent/ZA202003574B/en
Publication of WO2020133136A1 publication Critical patent/WO2020133136A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/20—Tampons, e.g. catamenial tampons; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/234—Cnidium (snowparsley)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/756—Phellodendron, e.g. corktree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/904—Stemonaceae (Stemona family), e.g. croomia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina

Definitions

  • the present invention relates to the technical field of medical devices, and more specifically, it relates to a catheter-medicated sanitary plug for treating vaginitis and a preparation method thereof.
  • Vaginitis or inflammation of the vagina, is a group of conditions that cause vulvovaginal symptoms such as itching, burning, irritation, and abnormal fluid flow.
  • Normal healthy women's vagina has a natural defense function against pathogen invasion due to the characteristics of anatomical tissue. If the vaginal opening is closed, the front and back walls of the vagina are close to each other, the proliferation of vaginal epithelial cells under the influence of estrogen and the keratinization of the superficial cells, the balance of vaginal acidity and alkalinity, so that the proliferation of pathogens that adapt to alkalinity is inhibited, and the cervical mucus is Alkaline, when the natural defense function of the vagina is destroyed, pathogens easily invade, leading to vaginal inflammation.
  • vaginal drug lavage can clear the abnormal vaginal discharge in the vagina, the drug cannot be kept in the vagina for a long time, and the drug effect cannot be fully exerted. Therefore, a catheter-medicine type sanitary tampon for treating vaginitis and its preparation method are proposed.
  • the object of the present invention is to provide a catheter-medicated tampon for treating vaginitis and its preparation method, which not only has a simple preparation method and is easy to realize, but also allows the drug to continue to act on the cervix and vaginal wall , So that the cervix, the entire vaginal wall and the vaginal vault can be exposed to drugs, the drug has a long-lasting effect, and the drug does not flow out, does not affect the efficacy of the drug, and does not pollute the underwear.
  • women have menstrual cramps, they can not only treat vaginitis, but also It can absorb menstrual blood, so it can also be used during menstruation. It has developed resistance to other topical drugs for recurrent vaginitis. It can be treated with the catheter drug type tampon, and will not develop drug resistance.
  • the present invention provides the following technical solutions:
  • a catheter medical sanitary tampon for treating vaginitis includes an outer tube, one end of the outer tube is oval closed structure, and the other end of the outer tube is open structure, the outer tube is cut at one end of oval closed structure There are four petal-shaped arc-shaped pieces, and the inner side of the outer tube near the end of the oval closed structure is movably inserted with a tampon, and the end of the tampons close to the outer tube is the oval closed structure is An oval structure, and one end of the oval structure is coated with a traditional Chinese medicine layer on the outside, the outer tube is an end of the open structure, an inner tube is inserted into the end, and one end of the inner tube is connected to the sanitary napkin The other end of the bar is in conflict, and the other end of the inner tube extends to the outside of the outer tube to which a push rod is fixedly connected.
  • the outer tube is used to protect the tampon, so that the tampon is isolated from the outside, which can effectively prevent the contamination of the tampon caused by hand contact;
  • the four petal-shaped arc-shaped pieces have a good closing effect. It can prevent the tampon located inside the outer tube from exposing itself and causing contamination, and when the push rod is pushed hard, the tampon can be smoothly pushed out;
  • the inner tube is not only used to close the open end of the outer tube, It also plays a guiding role, which can guide the push rod into the inside of the outer tube to push out the tampon.
  • the Chinese medicine layer has the effects of heat and dryness, and eliminates rot and muscles.
  • Putting it into the vagina can make the drug act on the cervix and vaginal wall. Because of the outflow of drugs, the effect of the drug is affected, and the sufficient drug loading is guaranteed. It acts on women's private parts and is easily absorbed by the skin and mucous membranes. It not only has antibacterial and anti-inflammatory effects on cervical erosion and various inflammations caused by vaginal bacteria, but also eliminates rot and health. Muscle and astringent effects can effectively promote the growth of cervical epithelial cells and the healing of erosive surfaces, and achieve the effect of treating the same specimens. It has developed resistance to other external drugs for recurrent vaginitis. It can be treated with this drug and will not form drug resistance. .
  • a cotton rope is fixedly connected to the other end of the tampon, and the end of the cotton rope away from the tampon extends through the inner tube and the push rod to the outside of the outer tube in sequence.
  • a channel for the cotton rope to pass through is centrally opened inside the push rod.
  • the end of the outer tube body near the opening structure thereof is further integrally provided with a constriction, and the end of the outer tube which is open structure is integrally provided with a trumpet-shaped stop ring.
  • the necking part can not only save processing materials, but also play a guiding role, which can guide the stable movement of the inner tube inside the outer tube.
  • the inner diameter of the necked portion is equal to the outer diameter of the inner tube.
  • the outer surface of the inner tube can be better fit with the inner surface of the necking portion, and the inner tube can be prevented from shaking when moving inside the outer tube.
  • a horn-shaped retaining ring is integrally formed at one end of the push rod away from the inner tube.
  • the horn-shaped retaining ring is used in conjunction with the horn-shaped limit ring to prevent the push rod from completely entering the inside of the outer tube, and to prevent the push rod from being operated.
  • the outer diameter of the horn-shaped retaining ring is larger than the outer diameter of the horn-shaped limit ring.
  • the limiting effect of the horn-shaped limit ring on the horn-shaped retaining ring can be ensured, and the rod can be prevented from completely entering the inside of the outer tube.
  • the traditional Chinese medicine layer is prepared by the following method:
  • step S2 Put the medicinal powder prepared in step S1 into a 300ml conical flask with a stopper, add 150ml of 95% ethanol, extract ultrasonically for 60-80min under the condition of room temperature kept at 25-30°C, use 1um micropore filter Membrane filtration to prepare extract filtrate;
  • step S3 Add the extract filtrate prepared in step S2 to a beaker and evaporate to dry with an alcohol lamp to prepare an extract extract;
  • step S4 The extract extract prepared in step S3 is completely dissolved in methanol and then filtered, the filtrate is transferred to a 500ml volumetric flask to make up to the mark, and then filtered through a 0.5um microporous filter membrane to prepare an extract;
  • step S5 Put the extract prepared in step S4 into a beaker with 300 ml of gel liquid inside, and stir well with a glass rod to prepare a gel-like Chinese medicine;
  • step S6 The Chinese medicine prepared in step S5 is evenly coated on the outside of one end of the oval structure of the tampon using a glass rod, that is, a Chinese medicine layer is prepared.
  • the preparation method of the traditional Chinese medicine layer is simple and easy to realize.
  • the extracted medicine inside the traditional Chinese medicine layer can continue to act on the cervix and vaginal wall, so that the cervix, the entire vaginal wall and the vaginal vault can be contacted with the drug, and the drug effect is lasting. , And the drug will not flow out, it will not affect the efficacy of the drug, it will not contaminate the underwear.
  • the menstruation is menstrual, it can not only treat vaginitis, but also absorb menstrual blood, so it can also be used during menstruation.
  • the drug has developed drug resistance.
  • the Chinese medicine layer can be used for treatment without drug resistance, and the Chinese medicine layer does not have any irritation and toxic side effects. It is a safe and reliable external preparation of pure Chinese medicine.
  • gel solution is prepared by the following method:
  • the method for preparing the gel liquid is relatively simple and easy to realize, and the prepared gel liquid has a good gel effect, thereby ensuring the therapeutic effect of the traditional Chinese medicine layer.
  • the invention also provides a method for preparing a catheter-medicated sanitary plug for treating vaginitis, which includes the following steps:
  • the first step is to prepare an outer tube made of polyethylene and an inner tube made of polyethylene and a push rod made of polyethylene by using an injection molding machine.
  • the nozzle temperature of the injection molding machine is 170-180°C, and the mold temperature is 30-40°C.
  • Injection pressure is 50-100MPa, injection time is 15-20s, cooling time is 12-16s, screw speed is 30-50rpm;
  • the second step is to directly purchase a tampon with a cotton rope at one end and an oval structure at one end, and use a glass rod to uniformly coat the Chinese medicine layer on the outside of the oval structure of the tampon;
  • the third step is to insert the tampon coated with the traditional Chinese medicine layer into the inside of the outer tube;
  • the fourth step is to seal the end of the push rod with glue to the end of the inner tube, and then pass the cotton string through the inner tube and the push rod in turn, and then insert the assembly of the push rod and the inner tube inside the outer tube, and make the inner One end of the tube is in conflict with one end of the tampon, and the push rod is kept outside the outer tube, that is, the catheter-medicated tampon for treating vaginitis is prepared.
  • the method for preparing the catheter medicine type sanitary tampon for treating vaginitis is relatively simple and the manufacturing cost is low, which is beneficial to promotion and popularization.
  • the present invention mainly has the following beneficial effects:
  • the outer tube is used to protect the tampon, so that the tampon is isolated from the outside world, which can effectively prevent the contamination of the tampon caused by hand contact;
  • the four petal-shaped arc-shaped pieces have a good closing function, which can prevent the tampon located inside the outer tube from being exposed and causing contamination, and when the push rod is pushed hard, it can also ensure hygiene
  • the sliver can be launched smoothly;
  • the inner tube is not only used to close the open end of the outer tube, but also plays a guiding role, which can guide the push rod to smoothly enter the inner tube to push out the tampon;
  • the traditional Chinese medicine layer has the effects of clearing away heat and dampness, removing rot and muscular muscles. Inserting it into the vagina can make the internal medicine act on the cervix and vaginal wall, and will not affect the efficacy of the medicine due to the outflow of the medicine, and ensure a sufficient amount of drug loading. It acts on women's private parts and is easily absorbed by the skin and mucous membranes.It not only has antibacterial and anti-inflammatory effects on cervical erosion and inflammation caused by various vaginal bacteria, but also can effectively promote the growth and erosion of cervical epithelial cells by removing rot, muscle growth and convergence.
  • the method for preparing the gel liquid is relatively simple and easy to implement, and the prepared gel liquid has a good gel effect, thereby ensuring the therapeutic effect of the traditional Chinese medicine layer;
  • the method for preparing the catheter medicine type sanitary tampon for treating vaginitis is relatively simple, the manufacturing cost is low, and it is beneficial to popularization and popularization.
  • FIG. 1 is a schematic structural diagram of an embodiment of the present invention
  • FIG. 2 is a schematic diagram of a side view of an embodiment of the present invention.
  • FIG. 3 is a schematic diagram of a side cross-sectional structure of an embodiment of the present invention.
  • FIG. 4 is a schematic diagram of the three-dimensional structure of FIG. 3;
  • FIG. 5 is a schematic diagram of an explosion structure according to an embodiment of the present invention.
  • FIG. 6 is a schematic structural diagram of an outer tube according to an embodiment of the present invention.
  • FIG. 7 is a schematic diagram of an enlarged structure at A in FIG. 6;
  • FIG. 8 is a schematic structural diagram of a push rod according to an embodiment of the present invention.
  • a catheter medical sanitary tampon for treating vaginitis includes an outer tube 1, one end of the outer tube 1 is an oval closed structure, and the other end of the outer tube 1 is an open structure.
  • Four petal-shaped arc-shaped pieces 9 are cut at one end of the outer tube 1 with an oval closed structure, and a sanitary tampon 5 is inserted into the end of the outer tube 1 near the end with an oval closed structure.
  • One end of the cotton sliver 5 near the outer tube 1 having an oval closed structure is an oval structure, and the other end of the tampons 5 having an oval structure is coated with a traditional Chinese medicine layer 6, and the outer tube 1 is an open structure
  • One end of the inner tube 2 is movably inserted inside, one end of the inner tube 2 is in contact with the other end of the tampon 5, and the other end of the inner tube 2 extends to the outer fixed connection of the outer tube 1 There is a putter 3.
  • the outer tube 1 is used to protect the tampon 5, so that the tampon 5 is isolated from the outside, which can effectively prevent the contamination of the tampon 5 caused by hand contact; the four petal-shaped arc-shaped pieces 9 have a good closing effect. It can prevent the tampon 5 inside the outer tube 1 from being exposed and causing contamination, and when the push rod 3 is pushed hard, the tampon 5 can be smoothly pushed out; the inner tube 2 is not only used to pull the outer tube
  • the open end of 1 is closed, and also plays a guiding role, which can guide the push rod 3 to smoothly enter the inside of the outer tube 1 to push the tampon 5 out.
  • the traditional Chinese medicine layer 6 has the effects of clearing away heat and dampness, and removing rot and muscles.
  • the drug acts on the wall of the cervix and vagina, it will not affect the efficacy of the drug due to the outflow of the drug, and guarantees a sufficient amount of drug. It acts on the private parts of women and is easily absorbed by the skin and mucous membranes. It not only has antibacterial effect on inflammation caused by cervical erosion and various vaginal bacteria Anti-inflammatory effect, and can effectively promote the growth of cervical epithelial cells and the healing of erosive surface through the effect of removing rot, muscle growth and convergence, to achieve the effect of treating the same specimens, and it has developed resistance to other external drugs for recurrent vaginitis. Treatment with this Chinese medicine layer 6 will not develop drug resistance.
  • the other end of the tampon 5 is also fixedly connected with a cotton rope 4, and the end of the cotton rope 4 away from the tampon 5 extends through the inner tube 2 and the push rod 3 in order to The outside of the outer tube 1.
  • the tampon 5 can be pulled out through the cotton rope 4.
  • the inside of the push rod 3 is centrally provided with a channel 11 through which the cotton rope 4 passes. It is convenient to use the channel 11 to lead the cotton rope 4 out, to prevent the cotton rope 4 from being cluttered and piled up inside the outer tube 1 to catch the inner tube 2, so that the push rod 3 can not be pushed, thereby preventing the tampon 5 from being pushed out and affecting the use.
  • the tube body of the outer tube 1 near the end of the opening structure is also integrally provided with a constriction portion 7, and the end of the outer tube 1 of the opening structure is further integrally provided with a trumpet-shaped stop ring 8.
  • the constriction 7 not only saves processing materials, but also plays a guiding role, and can guide the inner tube 2 to move steadily inside the outer tube 1.
  • the inner diameter of the constricted portion 7 is equal to the outer diameter of the inner tube 2.
  • the outer surface of the inner tube 2 can be better fit with the inner surface of the constricted portion 7, and the inner tube 2 can be prevented from shaking when moving inside the outer tube 1.
  • one end of the push rod 3 away from the inner tube 2 is integrally provided with a horn-shaped retaining ring 10.
  • the horn-shaped retaining ring 10 is used in conjunction with the horn-shaped stop ring 8 to prevent the push rod from completely entering the inside of the outer tube 1 and prevent the push rod 3 from being inoperable.
  • the outer diameter of the flared retaining ring 10 is larger than the outer diameter of the flared limiting ring 8.
  • the limiting effect of the horn-shaped stop ring 8 on the horn-shaped stop ring 10 can be ensured, and the rod can be prevented from completely entering the inside of the outer tube 1.
  • the traditional Chinese medicine layer 6 is prepared by the following method:
  • step S2 Place the medicinal powder prepared in step S1 into a 300ml conical flask with a stopper, add 150ml of 95% ethanol, extract ultrasonically for 80min at room temperature at 25°C, and filter with a 1um microporous filter. The extract filtrate is obtained;
  • step S3 Add the extract filtrate prepared in step S2 to a beaker and evaporate to dryness using an alcohol lamp to prepare an extract extract;
  • step S4 The extract extract prepared in step S3 is completely dissolved in methanol and then filtered, the filtrate is transferred to a 500ml volumetric flask to make up to the mark, and then filtered through a 0.5um microporous filter membrane to prepare an extract;
  • step S5 Put the extract prepared in step S4 into a beaker with 300 ml of gel liquid inside, and stir well with a glass rod to prepare a gel-like Chinese medicine;
  • step S6 The Chinese medicine prepared in step S5 is evenly coated on the outside of one end of the oval structure of the tampon 5 using a glass rod, that is, the Chinese medicine layer 6 is prepared.
  • the gel solution is prepared by the following method:
  • the method for preparing the gel liquid is relatively simple and easy to implement, and the prepared gel liquid has a good gel effect, thereby ensuring the therapeutic effect of the traditional Chinese medicine layer 6.
  • the invention also provides a method for preparing a catheter-medicated sanitary plug for treating vaginitis, which includes the following steps:
  • the first step is to use an injection molding machine to prepare the outer tube 1 made of polyethylene and the inner tube 2 made of polyethylene and the push rod 3 made of polyethylene.
  • the nozzle temperature of the injection molding machine is 170-180°C and the mold temperature is 30- 40°C, injection pressure 50-100MPa, injection time 15-20s, cooling time 12-16s, screw speed 30-50rpm;
  • the second step is to directly purchase a tampon 5 with a cotton rope 4 at one end and an oval structure at one end, and use a glass rod to uniformly coat the Chinese medicine layer 6 on the outside of the oval structure of the tampon 5;
  • the third step is to insert the tampon 5 coated with the traditional Chinese medicine layer 6 into the inside of the outer tube 1;
  • Step 4 Seal the end of the push rod 3 with glue at one end of the inner tube 2, and then pass the cotton string 4 through the inner tube 2 and the push rod 3 in turn, and then insert the assembly of the push rod 3 and the inner tube 2 outside
  • the inside of the tube 1 makes one end of the inner tube 2 interfere with the one end of the tampon 5, and the push rod 3 is kept outside the outer tube 1, that is, the catheter-medicated tampon for treating vaginitis is prepared.
  • the method for preparing the catheter medicine type sanitary tampon for treating vaginitis is relatively simple and the manufacturing cost is low, which is beneficial to promotion and popularization.
  • Example 1 The difference from Example 1 is that the traditional Chinese medicine layer 6 is prepared by the following method:
  • step S2 Put the medicinal powder prepared in step S1 into a 300ml conical flask with a stopper, add 150ml of 95% ethanol, extract ultrasonically at room temperature at 28°C for 70min, and filter with a 1um microporous filter. The extract filtrate is obtained;
  • step S3 Add the extract filtrate prepared in step S2 to a beaker and evaporate to dry with an alcohol lamp to prepare an extract extract;
  • step S4 The extract extract prepared in step S3 is completely dissolved in methanol and then filtered, the filtrate is transferred to a 500ml volumetric flask to make up to the mark, and then filtered through a 0.5um microporous filter membrane to prepare an extract;
  • step S5 Place the extract prepared in step S4 into a beaker with 300 ml of gel solution inside, and stir well with a glass rod to prepare a gel-like Chinese medicine;
  • step S6 The Chinese medicine prepared in step S5 is evenly coated on the outside of one end of the oval structure of the tampon 5 using a glass rod, that is, the Chinese medicine layer 6 is prepared.
  • the preparation method of the traditional Chinese medicine layer 6 is simple and easy to realize.
  • the extracted medicine inside the traditional Chinese medicine layer 6 can continue to act on the cervix and vaginal wall, so that the cervix, the entire vaginal wall and the posterior vault of the vagina can contact the drugs and drugs
  • the effect is long-lasting, and the drug will not flow out, affect the efficacy of the drug, and will not contaminate the underwear.
  • women have menstrual cramps, they can not only treat vaginitis, but also absorb menstrual blood, so they can also be used during menstruation.
  • Other external medicines have developed drug resistance, and can be treated with the Chinese medicine layer without drug resistance, and the Chinese medicine layer 6 does not have any stimulating effects and toxic side effects, and is a safe and reliable pure Chinese medicine external preparation.
  • the gel solution is prepared by the following method:
  • the method for preparing the gel liquid is relatively simple and easy to implement, and the prepared gel liquid has a good gel effect, thereby ensuring the therapeutic effect of the traditional Chinese medicine layer 6.
  • Example 1 The difference from Example 1 is that the traditional Chinese medicine layer 6 is prepared by the following method:
  • step S2 Put the medicinal powder prepared in step S1 into a 300ml conical flask with a stopper, add 150ml of 95% ethanol, extract ultrasonically for 60min under the condition that the room temperature is kept at 30°C, and filter with a 1um microporous filter membrane. The extract filtrate is obtained;
  • step S3 Add the extract filtrate prepared in step S2 to a beaker and evaporate to dry with an alcohol lamp to prepare an extract extract;
  • step S4 The extract extract prepared in step S3 is completely dissolved in methanol and then filtered, the filtrate is transferred to a 500ml volumetric flask to make up to the mark, and then filtered through a 0.5um microporous filter membrane to prepare an extract;
  • step S5 Put the extract prepared in step S4 into a beaker with 300 ml of gel liquid inside, and stir well with a glass rod to prepare a gel-like Chinese medicine;
  • step S6 The Chinese medicine prepared in step S5 is evenly coated on the outside of one end of the oval structure of the tampon 5 using a glass rod, that is, the Chinese medicine layer 6 is prepared.
  • the preparation method of the traditional Chinese medicine layer 6 is simple and easy to realize.
  • the extracted medicine inside the traditional Chinese medicine layer 6 can continue to act on the cervix and vaginal wall, so that the cervix, the entire vaginal wall and the posterior vault of the vagina can contact the drugs and drugs
  • the effect is long-lasting, and the drug will not flow out, affect the efficacy of the drug, and will not contaminate the underwear.
  • women have menstrual cramps, they can not only treat vaginitis, but also absorb menstrual blood, so they can also be used during menstruation.
  • Other external medicines have developed drug resistance, and can be treated with the Chinese medicine layer without drug resistance, and the Chinese medicine layer 6 does not have any stimulating effects and toxic side effects, and is a safe and reliable pure Chinese medicine external preparation.
  • the gel solution is prepared by the following method:
  • the method for preparing the gel liquid is relatively simple and easy to implement, and the prepared gel liquid has a good gel effect, thereby ensuring the therapeutic effect of the traditional Chinese medicine layer 6.
  • Example 2 is the best example.
  • the prepared traditional Chinese medicine layer 6 has drugs inside that can continue to act on the cervix and vaginal wall, so that the cervix, the entire vaginal wall and the vagina
  • the back dome can be contacted with drugs, the drug has a long-lasting effect, and the drug does not flow out, does not affect the efficacy, does not pollute the underwear, and is used with the tampon 5 to not only treat vaginitis but also absorb when the menstruation is in menstruation Menstrual blood, so it can also be used during menstruation.
  • the recurrent vaginitis has developed resistance to other topical drugs. It can be treated with this Chinese medicine layer without drug resistance, and this Chinese medicine layer does not have any stimulating effects and toxic side effects. A safe and reliable external preparation of pure Chinese medicine.
  • the catheter-type sanitary tampon for vaginitis the outer tube 1 is used to protect the tampon 5, so that the tampon 5 is isolated from the outside world, which can effectively prevent the contamination of the tampon 5 caused by hand contact;
  • a petal-shaped arc-shaped piece 9 has a good closing function, which can prevent the tampon 5 located inside the outer tube 1 from being exposed and causing contamination, and when the push rod 3 is pushed hard, the tampon can also be guaranteed 5 can be pushed out smoothly;
  • the inner tube 2 is not only used to close the open end of the outer tube 1, but also plays a guiding role, which can guide the push rod 3 to smoothly enter the inside of the outer tube 1 to push out the tampon 5;
  • the Chinese medicine layer 6 has heat removal The effect of dryness, rot and muscles can be inserted into the vagina to make the internal drugs act on the cervix and vaginal wall, and will not affect the efficacy of the drugs due to the outflow of drugs
  • the elliptical end of the outer tube 1 is brought into contact with the patient's vaginal opening, and the push rod 3 is operated to push the inner tube 2 into the inside of the outer tube 1, and the tampon 5 and the traditional Chinese medicine layer are pushed in in a similar injection manner In the vagina, the inner tube 2 and the outer tube 1 and the push rod 3 can be removed together. When it needs to be replaced, just pull out the tampon 5 through the cotton rope 4.

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Abstract

一种治疗阴道炎的导管药物型卫生栓，包括外管(1)，所述外管(1)的一端为椭圆形封闭结构，且外管(1)的另一端为开口结构，所述外管(1)为椭圆形封闭结构的一端切割有四个花瓣型弧形片(9)。上述卫生栓的制备方法简单，容易实现，还可使得中药层(6)内部的药物持续作用于宫颈及阴道壁，使宫颈、整个阴道壁及阴道后穹隆均可接触药物，药物作用持久，而且药物不会流出，不会影响药效，不会污染内裤，在女性月经来潮时，不仅可以治疗阴道炎，还能吸收经血，故经期也能使用，对于反复发作的阴道炎对其他外用药物已形成耐药，可使用该中药层进行治疗，不会形成耐药。

Description

一种治疗阴道炎的导管药物型卫生栓及其制备方法 技术领域
本发明涉及医疗器械技术领域，更具体地说，它涉及一种治疗阴道炎的导管药物型卫生栓及其制备方法。
背景技术
阴道炎即阴道炎症，是导致外阴阴道症状如瘙痒、灼痛、刺激和异常流液的一组病症。正常健康妇女阴道由于解剖组织的特点对病原体的侵入有自然防御功能。如阴道口的闭合，阴道前后壁紧贴，阴道上皮细胞在雌激素的影响下的增生和表层细胞角化，阴道酸碱度保持平衡，使适应碱性的病原体的繁殖受到抑制，而颈管黏液呈碱性，当阴道的自然防御功能受到破坏时，病原体易于侵入，导致阴道炎症。
阴道炎用药中泡腾片等有药渣形成，部分患者会出现阴道烧灼感、瘙痒或其他粘膜刺激症状；凝胶类药物容易流出，不仅丢失部分药效，达不到应有的治疗效果，而且会污染内裤。阴道药物灌洗虽然能清除阴道内的异常白带，但药物不能长时间存留在阴道内，不能充分发挥药效，为此，提出一种治疗阴道炎的导管药物型卫生栓及其制备方法。
发明内容
针对现有技术存在的不足，本发明的目的在于提供一种治疗阴道炎的导管药物型卫生栓及其制备方法，其不仅制备方法简单，容易实现，还能是药物持续作用于宫颈及阴道壁，使宫颈、整个阴道壁及阴道后穹隆均可接触药物，药物作用持久，而且药物不会流出，不会影响药效，不会污染内裤，在女性月经来潮时，不仅可以治疗阴道炎，还能吸收经血，故经期也能使用，对反复发作的阴道炎对其他外用药物已形成耐药，可使用该导管药物型卫生栓进行治疗，不会形成耐药。
为实现上述目的，本发明提供了如下技术方案：
一种治疗阴道炎的导管药物型卫生栓，包括外管，所述外管的一 端为椭圆形封闭结构，且外管的另一端为开口结构，所述外管为椭圆形封闭结构的一端切割有四个花瓣型弧形片，且所述外管的内部靠近其为椭圆形封闭结构的一端活动安插有卫生棉条，所述卫生棉条靠近所述外管为椭圆形封闭结构的一端为椭圆形结构，且所述卫生棉条为椭圆形结构的一端外部涂覆有中药层，所述外管为开口结构的一端内部活动安插有内管，所述内管的一端与所述卫生棉条的另一端相抵触，且所述内管的另一端延伸至所述外管的外部固定连接有推杆。
通过采用上述技术方案，外管用来防护卫生棉条，使得卫生棉条与外界隔离，可以有效防止手接触卫生棉条导致其污染的问题；四个花瓣型弧形片具有较好的收口作用，可防止位于外管内部的卫生棉条自行露出导致被污染的现象发生，且在用力推动推杆时，又可保证卫生棉条能够顺利推出；内管不仅用于将外管的开口端封闭，还起到导向作用，可引导推杆顺利进入外管的内部将卫生棉条推出，中药层具有清热燥湿、祛腐生肌之功效，置入阴道能使药物作用于宫颈及阴道壁，不会因为药物流出而影响药效，保障足够的载药量，作用于女性私处易被皮肤和粘膜吸收,不仅对宫颈糜烂及各类阴道病菌引起的炎症具有抗菌消炎的作用,而且通过祛腐、生肌和收敛作用能有效促进宫颈上皮细胞的生长和糜烂面的愈合,达到标本同治的效果，对反复发作的阴道炎对其他外用药物已形成耐药，可使用该药物治疗，不会形成耐药。
进一步的，所述卫生棉条的另一端还固定连接有棉绳，所述棉绳远离所述卫生棉条的一端依次贯穿所述内管和所述推杆延伸至所述外管的外部。
通过采用上述技术方案，便于在更换卫生棉条时，通过棉绳将卫生棉条拉出。
进一步的，所述推杆的内部居中开设有用于所述棉绳穿过的通道。
通过采用上述技术方案，便于利用通道将棉绳引出，防止棉绳杂乱的堆放在外管的内部卡住内管，可避免推杆推不动，从而避免卫生棉条无法推出，避免影响使用。
进一步的，所述外管的管身靠近其为开口结构的一端还一体设有缩口部，且所述外管为开口结构的一端端部还一体设有喇叭状限位圈。
通过采用上述技术方案，缩口部不仅可以节约加工材料，还起到导向的作用，可引导内管在外管内部稳定的移动。
进一步的，所述缩口部的内径与所述内管的外径相等。
通过采用上述技术方案，使得内管的外表面可以与缩口部的内表面较好的贴合，可防止内管在外管内部移动时产生晃动。
进一步的，所述推杆远离所述内管的一端端部一体设有喇叭状挡圈。
通过采用上述技术方案，喇叭状挡圈与喇叭状限位圈相配合使用，可防止推杆完全进入外管的内部，可避免无法操作推杆。
进一步的，所述喇叭状挡圈的外径大于所述喇叭状限位圈的外径。
通过采用上述技术方案，可保证喇叭状限位圈对喇叭状挡圈的限制作用，可防止杆完全进入外管的内部。
进一步的，所述中药层由如下方法制备：
取以下原料按重量份称量：一枝黄花2份、苦参2份、生百部1份、土槿皮1份、蛇床子1份、地肤子1份、白鲜皮1份、炒黄柏1份和羊蹄根1份；
S1、将称量好的一枝黄花、苦参、生百部、土槿皮、蛇床子、地肤子、白鲜皮、炒黄柏和羊蹄根清洗干净后烘干并磨粉，制得药材粉末；
S2、将步骤S1制得的药材粉末置入300ml具塞磨口锥形瓶中， 加入95％乙醇150ml，在室温保持在25-30℃的条件下超声提取60-80min，采用1um微孔滤膜过滤，制得提取物滤液；
S3、将步骤S2制得的提取物滤液加入烧杯中，利用酒精灯进行蒸干，制得提取物浸膏；
S4、将步骤S3制得的提取物浸膏用甲醇完全溶解后过滤，将滤液转入500ml的容量瓶中定容至刻度线，然后经0.5um微孔滤膜过滤，制得提取物；
S5、将步骤S4制得的提取物置入内部加有300ml凝胶液的烧杯中，采用玻璃棒搅匀，即制得凝胶状的中药剂；
S6、将步骤S5制得的中药剂，采用玻璃棒均匀的涂覆在卫生棉条为椭圆形结构的一端外部，即制得中药层。
通过采用上述技术方案，使得中药层的制备方法简单，容易实现，中药层内部的提取药物可持续作用于宫颈及阴道壁，使宫颈、整个阴道壁及阴道后穹隆均可接触药物，药物作用持久，而且药物不会流出，不会影响药效，不会污染内裤，在女性月经来潮时，不仅可以治疗阴道炎，还能吸收经血，故经期也能使用，对于反复发作的阴道炎对其他外用药物已形成耐药，可使用该中药层进行治疗，不会形成耐药，而且该中药层无任何刺激作用及毒副作用,是一种安全可靠的纯中药外用制剂。
进一步的，所述凝胶液由如下方法制备：
取以下原料按重量份称量：丙烯酸交联树脂10-12份、三乙醇胺12-14份、甘油60-80份、平平加50-60份、亚硫酸氢钠0.5-1份、依地酸二钠0.5-1份、月桂氮酮8-10份和蒸馏水300-500份；
a、在常温下将三乙醇胺、甘油、平平加、蒸馏水、亚硫酸氢钠和依地酸二钠以及月桂氮酮加入烧杯中，利用玻璃棒搅拌均匀直至无固体存在；
b、在搅拌的情况下缓慢加入丙烯酸交联树脂，直至丙烯酸交联 树脂完全溶解，制得凝胶液。
通过采用上述技术方案，使得制备凝胶液的方法比较简单，容易实现，且制备的凝胶液凝胶效果较好，进而保证中药层的治疗效果。
本发明还提出一种治疗阴道炎的导管药物型卫生栓的制备方法，包括如下步骤：
第一步、利用注塑机制备聚乙烯材质的外管和聚乙烯材质的内管以及聚乙烯材质的推杆，所述注塑机的喷嘴温度为170-180℃、模具温度为30-40℃、注射压力为50-100MPa、注射时间为15-20s、冷却时间12-16s、螺杆转速为30-50rpm；
第二步、到市面上直接采购一端带有棉绳且一端为椭圆形结构的卫生棉条，采用玻璃棒均匀地在卫生棉条为椭圆形结构的一端外部涂覆中药层；
第三步、将涂覆有中药层的卫生棉条插入外管的内部；
第四步、将推杆的一端采用胶水封装在内管的一端，然后将棉绳依次穿过内管与推杆，再将推杆与内管的组装体安插在外管的内部，并使得内管的一端与卫生棉条的一端相抵触，推杆保持在外管的外部，即制得该治疗阴道炎的导管药物型卫生栓。
通过采用上述技术方案，使得制备该治疗阴道炎的导管药物型卫生栓的方法比较简单，制作成本较低，有利于推广和普及。
综上所述，本发明主要具有以下有益效果：
1、本发明，外管用来防护卫生棉条，使得卫生棉条与外界隔离，可以有效防止手接触卫生棉条导致其污染的问题；
2、本发明,四个花瓣型弧形片具有较好的收口作用，可防止位于外管内部的卫生棉条自行露出导致被污染的现象发生，且在用力推动推杆时，又可保证卫生棉条能够顺利推出；
3、本发明,内管不仅用于将外管的开口端封闭，还起到导向作用，可引导推杆顺利进入外管的内部将卫生棉条推出；
4、本发明,中药层具有清热燥湿、祛腐生肌之功效，置入阴道能使其内部药物作用于宫颈及阴道壁，不会因为药物流出而影响药效，保障足够的载药量，作用于女性私处易被皮肤和粘膜吸收,不仅对宫颈糜烂及各类阴道病菌引起的炎症具有抗菌消炎的作用,而且通过祛腐、生肌和收敛作用能有效促进宫颈上皮细胞的生长和糜烂面的愈合,达到标本同治的效果，对于反复发作的阴道炎对其他外用药物已形成耐药，可使用该药物治疗，不会形成耐药，该中药层无任何刺激作用及毒副作用,是一种安全可靠的纯中药外用制剂。
5、本发明,制备凝胶液的方法比较简单，容易实现，且制备的凝胶液凝胶效果较好，进而保证中药层的治疗效果；
6、本发明,制备该治疗阴道炎的导管药物型卫生栓的方法比较简单，制作成本较低，有利于推广和普及。
附图说明
图1为本发明一种实施方式的结构示意图；
图2为本发明一种实施方式的侧视结构示意图；
图3为本发明一种实施方式的侧视剖视结构示意图；
图4为图3的立体结构示意图；
图5为本发明一种实施方式的爆炸结构示意图；
图6为本发明一种实施方式的外管的结构示意图；
图7为图6中A处的放大结构示意图；
图8为本发明一种实施方式的推杆的结构示意图。
图中：1、外管；2、内管；3、推杆；4、棉绳；5、卫生棉条；6、中药层；7、缩口部；8、喇叭状限位圈；9、花瓣型弧形片；10、喇叭状挡圈；11、通道。
具体实施方式
实施例1
以下结合附图1-8对本发明作进一步详细说明。
一种治疗阴道炎的导管药物型卫生栓，如图1-8所示，包括外管1，所述外管1的一端为椭圆形封闭结构，且外管1的另一端为开口结构，所述外管1为椭圆形封闭结构的一端切割有四个花瓣型弧形片9，且所述外管1的内部靠近其为椭圆形封闭结构的一端活动安插有卫生棉条5，所述卫生棉条5靠近所述外管1为椭圆形封闭结构的一端为椭圆形结构，且所述卫生棉条5为椭圆形结构的一端外部涂覆有中药层6，所述外管1为开口结构的一端内部活动安插有内管2，所述内管2的一端与所述卫生棉条5的另一端相抵触，且所述内管2的另一端延伸至所述外管1的外部固定连接有推杆3。
外管1用来防护卫生棉条5，使得卫生棉条5与外界隔离，可以有效防止手接触卫生棉条5导致其污染的问题；四个花瓣型弧形片9具有较好的收口作用，可防止位于外管1内部的卫生棉条5自行露出导致被污染的现象发生，且在用力推动推杆3时，又可保证卫生棉条5能够顺利推出；内管2不仅用于将外管1的开口端封闭，还起到导向作用，可引导推杆3顺利进入外管1的内部将卫生棉条5推出，中药层6具有清热燥湿、祛腐生肌之功效，置入阴道能使药物作用于宫颈及阴道壁，不会因为药物流出而影响药效，保障足够的载药量，作用于女性私处易被皮肤和粘膜吸收,不仅对宫颈糜烂及各类阴道病菌引起的炎症具有抗菌消炎的作用,而且通过祛腐、生肌和收敛作用能有效促进宫颈上皮细胞的生长和糜烂面的愈合,达到标本同治的效果，对反复发作的阴道炎对其他外用药物已形成耐药，可使用该中药层6治疗，不会形成耐药。
较佳地，所述卫生棉条5的另一端还固定连接有棉绳4，所述棉绳4远离所述卫生棉条5的一端依次贯穿所述内管2和所述推杆3延伸至所述外管1的外部。便于在更换卫生棉条5时，通过棉绳4将卫生棉条5拉出。
较佳地，所述推杆3的内部居中开设有用于所述棉绳4穿过的通 道11。便于利用通道11将棉绳4引出，防止棉绳4杂乱的堆放在外管1的内部卡住内管2，可避免推杆3推不动，从而避免卫生棉条5无法推出，避免影响使用。
较佳地，所述外管1的管身靠近其为开口结构的一端还一体设有缩口部7，且所述外管1为开口结构的一端端部还一体设有喇叭状限位圈8。缩口部7不仅可以节约加工材料，还起到导向的作用，可引导内管2在外管1内部稳定的移动。
较佳地，所述缩口部7的内径与所述内管2的外径相等。使得内管2的外表面可以与缩口部7的内表面较好的贴合，可防止内管2在外管1内部移动时产生晃动。
较佳地，所述推杆3远离所述内管2的一端端部一体设有喇叭状挡圈10。喇叭状挡圈10与喇叭状限位圈8相配合使用，可防止推杆完全进入外管1的内部，可避免无法操作推杆3。
较佳地，所述喇叭状挡圈10的外径大于所述喇叭状限位圈8的外径。可保证喇叭状限位圈8对喇叭状挡圈10的限制作用，可防止杆完全进入外管1的内部。
较佳地，所述中药层6由如下方法制备：
取以下原料按重量份称量：一枝黄花2份、苦参2份、生百部1份、土槿皮1份、蛇床子1份、地肤子1份、白鲜皮1份、炒黄柏1份和羊蹄根1份；
S1、将称量好的一枝黄花、苦参、生百部、土槿皮、蛇床子、地肤子、白鲜皮、炒黄柏和羊蹄根清洗干净后烘干并磨粉，制得药材粉末；
S2、将步骤S1制得的药材粉末置入300ml具塞磨口锥形瓶中，加入95％乙醇150ml，在室温保持在25℃的条件下超声提取80min，采用1um微孔滤膜过滤，制得提取物滤液；
S3、将步骤S2制得的提取物滤液加入烧杯中，利用酒精灯进行 蒸干，制得提取物浸膏；
S4、将步骤S3制得的提取物浸膏用甲醇完全溶解后过滤，将滤液转入500ml的容量瓶中定容至刻度线，然后经0.5um微孔滤膜过滤，制得提取物；
S5、将步骤S4制得的提取物置入内部加有300ml凝胶液的烧杯中，采用玻璃棒搅匀，即制得凝胶状的中药剂；
S6、将步骤S5制得的中药剂，采用玻璃棒均匀的涂覆在卫生棉条5为椭圆形结构的一端外部，即制得中药层6。
较佳地，所述凝胶液由如下方法制备：
取以下原料按重量份称量：丙烯酸交联树脂10份、三乙醇胺12份、甘油60份、平平加50份、亚硫酸氢钠0.5份、依地酸二钠0.5份、月桂氮酮8份和蒸馏水300份；
a、在常温下将三乙醇胺、甘油、平平加、蒸馏水、亚硫酸氢钠和依地酸二钠以及月桂氮酮加入烧杯中，利用玻璃棒搅拌均匀直至无固体存在；
b、在搅拌的情况下缓慢加入丙烯酸交联树脂，直至丙烯酸交联树脂完全溶解，制得凝胶液。
通过采用上述技术方案，使得制备凝胶液的方法比较简单，容易实现，且制备的凝胶液凝胶效果较好，进而保证中药层6的治疗效果。
本发明还提出一种治疗阴道炎的导管药物型卫生栓的制备方法，包括如下步骤：
第一步、利用注塑机制备聚乙烯材质的外管1和聚乙烯材质的内管2以及聚乙烯材质的推杆3，所述注塑机的喷嘴温度为170-180℃、模具温度为30-40℃、注射压力为50-100MPa、注射时间为15-20s、冷却时间12-16s、螺杆转速为30-50rpm；
第二步、到市面上直接采购一端带有棉绳4且一端为椭圆形结构的卫生棉条5，采用玻璃棒均匀地在卫生棉条5为椭圆形结构的一端 外部涂覆中药层6；
第三步、将涂覆有中药层6的卫生棉条5插入外管1的内部；
第四步、将推杆3的一端采用胶水封装在内管2的一端，然后将棉绳4依次穿过内管2与推杆3，再将推杆3与内管2的组装体安插在外管1的内部，并使得内管2的一端与卫生棉条5的一端相抵触，推杆3保持在外管1的外部，即制得该治疗阴道炎的导管药物型卫生栓。
通过采用上述技术方案，使得制备该治疗阴道炎的导管药物型卫生栓的方法比较简单，制作成本较低，有利于推广和普及。
实施例2
与实施例1的不同之处在于所述中药层6由如下方法制备：
取以下原料按重量份称量：一枝黄花2份、苦参2份、生百部1份、土槿皮1份、蛇床子1份、地肤子1份、白鲜皮1份、炒黄柏1份和羊蹄根1份；
S1、将称量好的一枝黄花、苦参、生百部、土槿皮、蛇床子、地肤子、白鲜皮、炒黄柏和羊蹄根清洗干净后烘干并磨粉，制得药材粉末；
S2、将步骤S1制得的药材粉末置入300ml具塞磨口锥形瓶中，加入95％乙醇150ml，在室温保持在28℃的条件下超声提取70min，采用1um微孔滤膜过滤，制得提取物滤液；
S3、将步骤S2制得的提取物滤液加入烧杯中，利用酒精灯进行蒸干，制得提取物浸膏；
S4、将步骤S3制得的提取物浸膏用甲醇完全溶解后过滤，将滤液转入500ml的容量瓶中定容至刻度线，然后经0.5um微孔滤膜过滤，制得提取物；
S5、将步骤S4制得的提取物置入内部加有300ml凝胶液的烧杯 中，采用玻璃棒搅匀，即制得凝胶状的中药剂；
S6、将步骤S5制得的中药剂，采用玻璃棒均匀的涂覆在卫生棉条5为椭圆形结构的一端外部，即制得中药层6。
通过采用上述技术方案，使得中药层6的制备方法简单，容易实现，中药层6内部的提取药物可持续作用于宫颈及阴道壁，使宫颈、整个阴道壁及阴道后穹隆均可接触药物，药物作用持久，而且药物不会流出，不会影响药效，不会污染内裤，在女性月经来潮时，不仅可以治疗阴道炎，还能吸收经血，故经期也能使用，对于反复发作的阴道炎对其他外用药物已形成耐药，可使用该中药层进行治疗，不会形成耐药，而且该中药层6无任何刺激作用及毒副作用,是一种安全可靠的纯中药外用制剂。
较佳地，所述凝胶液由如下方法制备：
取以下原料按重量份称量：丙烯酸交联树脂11份、三乙醇胺13份、甘油70份、平平加55份、亚硫酸氢钠0.8份、依地酸二钠0.8份、月桂氮酮9份和蒸馏水400份；
a、在常温下将三乙醇胺、甘油、平平加、蒸馏水、亚硫酸氢钠和依地酸二钠以及月桂氮酮加入烧杯中，利用玻璃棒搅拌均匀直至无固体存在；
b、在搅拌的情况下缓慢加入丙烯酸交联树脂，直至丙烯酸交联树脂完全溶解，制得凝胶液。
通过采用上述技术方案，使得制备凝胶液的方法比较简单，容易实现，且制备的凝胶液凝胶效果较好，进而保证中药层6的治疗效果。
实施例3
与实施例1的不同之处在于所述中药层6由如下方法制备：
取以下原料按重量份称量：一枝黄花2份、苦参2份、生百部1份、土槿皮1份、蛇床子1份、地肤子1份、白鲜皮1份、炒黄柏1 份和羊蹄根1份；
S1、将称量好的一枝黄花、苦参、生百部、土槿皮、蛇床子、地肤子、白鲜皮、炒黄柏和羊蹄根清洗干净后烘干并磨粉，制得药材粉末；
S2、将步骤S1制得的药材粉末置入300ml具塞磨口锥形瓶中，加入95％乙醇150ml，在室温保持在30℃的条件下超声提取60min，采用1um微孔滤膜过滤，制得提取物滤液；
S3、将步骤S2制得的提取物滤液加入烧杯中，利用酒精灯进行蒸干，制得提取物浸膏；
S4、将步骤S3制得的提取物浸膏用甲醇完全溶解后过滤，将滤液转入500ml的容量瓶中定容至刻度线，然后经0.5um微孔滤膜过滤，制得提取物；
S5、将步骤S4制得的提取物置入内部加有300ml凝胶液的烧杯中，采用玻璃棒搅匀，即制得凝胶状的中药剂；
S6、将步骤S5制得的中药剂，采用玻璃棒均匀的涂覆在卫生棉条5为椭圆形结构的一端外部，即制得中药层6。
通过采用上述技术方案，使得中药层6的制备方法简单，容易实现，中药层6内部的提取药物可持续作用于宫颈及阴道壁，使宫颈、整个阴道壁及阴道后穹隆均可接触药物，药物作用持久，而且药物不会流出，不会影响药效，不会污染内裤，在女性月经来潮时，不仅可以治疗阴道炎，还能吸收经血，故经期也能使用，对于反复发作的阴道炎对其他外用药物已形成耐药，可使用该中药层进行治疗，不会形成耐药，而且该中药层6无任何刺激作用及毒副作用,是一种安全可靠的纯中药外用制剂。
较佳地，所述凝胶液由如下方法制备：
取以下原料按重量份称量：丙烯酸交联树脂12份、三乙醇胺14份、甘油80份、平平加60份、亚硫酸氢钠1份、依地酸二钠1份、 月桂氮酮10份和蒸馏水500份；
a、在常温下将三乙醇胺、甘油、平平加、蒸馏水、亚硫酸氢钠和依地酸二钠以及月桂氮酮加入烧杯中，利用玻璃棒搅拌均匀直至无固体存在；
b、在搅拌的情况下缓慢加入丙烯酸交联树脂，直至丙烯酸交联树脂完全溶解，制得凝胶液。
通过采用上述技术方案，使得制备凝胶液的方法比较简单，容易实现，且制备的凝胶液凝胶效果较好，进而保证中药层6的治疗效果。
对实施例1-3治疗阴道炎的导管药物型卫生栓的使用统计结果如下表：
实施例 使用结果
1 100人使用治愈83人，治愈率为83％
2 100人使用治愈93人，治愈率为93％
3 100人使用治愈89人，治愈率为89％
从上表统计结果比较分析可知实施例2为最优实施例，通过采用上述技术方案，制备的中药层6，其内部的药物可持续作用于宫颈及阴道壁，使宫颈、整个阴道壁及阴道后穹隆均可接触药物，药物作用持久，而且药物不会流出，不会影响药效，不会污染内裤，搭配卫生棉条5使用，在女性月经来潮时，不仅可以治疗阴道炎，还能吸收经血，故经期也能使用，对于反复发作的阴道炎对其他外用药物已形成耐药，可使用该中药层进行治疗，不会形成耐药，而且该中药层无任何刺激作用及毒副作用,是一种安全可靠的纯中药外用制剂。
工作原理：该治疗阴道炎的导管药物型卫生栓，外管1用来防护卫生棉条5，使得卫生棉条5与外界隔离，可以有效防止手接触卫生棉条5导致其污染的问题；四个花瓣型弧形片9具有较好的收口作用，可防止位于外管1内部的卫生棉条5自行露出导致被污染的现象发 生，且在用力推动推杆3时，又可保证卫生棉条5能够顺利推出；内管2不仅用于将外管1的开口端封闭，还起到导向作用，可引导推杆3顺利进入外管1的内部将卫生棉条5推出；中药层6具有清热燥湿、祛腐生肌之功效，置入阴道能使其内部药物作用于宫颈及阴道壁，不会因为药物流出而影响药效，保障足够的载药量，作用于女性私处易被皮肤和粘膜吸收,不仅对宫颈糜烂及各类阴道病菌引起的炎症具有抗菌消炎的作用,而且通过祛腐、生肌和收敛作用能有效促进宫颈上皮细胞的生长和糜烂面的愈合,达到标本同治的效果，对于反复发作的阴道炎对其他外用药物已形成耐药，可使用该药物治疗，不会形成耐药，该中药层无任何刺激作用及毒副作用,是一种安全可靠的纯中药外用制剂。
使用时，将外管1椭圆形的端部与患者阴道口接触，操作推杆3将内管2向外管1的内部推进，以类似注射的方式，将卫生棉条5及中药层推入阴道内，再将内管2和外管1以及推杆3一起移除即可，在需要更换时，只需通过棉绳4将卫生棉条5拉出即可。
本具体实施例仅仅是对本发明的解释，其并不是对本发明的限制，本领域技术人员在阅读完本说明书后可以根据需要对本实施例做出没有创造性贡献的修改，但只要在本发明的权利要求范围内都受到专利法的保护。

Claims (10)

  1. 一种治疗阴道炎的导管药物型卫生栓，包括外管(1)，其特征在于：所述外管(1)的一端为椭圆形封闭结构，且外管(1)的另一端为开口结构，所述外管(1)为椭圆形封闭结构的一端切割有四个花瓣型弧形片(9)，且所述外管(1)的内部靠近其为椭圆形封闭结构的一端活动安插有卫生棉条(5)，所述卫生棉条(5)靠近所述外管(1)为椭圆形封闭结构的一端为椭圆形结构，且所述卫生棉条(5)为椭圆形结构的一端外部涂覆有中药层(6)，所述外管(1)为开口结构的一端内部活动安插有内管(2)，所述内管(2)的一端与所述卫生棉条(5)的另一端相抵触，且所述内管(2)的另一端延伸至所述外管(1)的外部固定连接有推杆(3)。
  2. 根据权利要求1所述的一种治疗阴道炎的导管药物型卫生栓，其特征在于：所述卫生棉条(5)的另一端还固定连接有棉绳(4)，所述棉绳(4)远离所述卫生棉条(5)的一端依次贯穿所述内管(2)和所述推杆(3)延伸至所述外管(1)的外部。
  3. 根据权利要求2所述的一种治疗阴道炎的导管药物型卫生栓，其特征在于：所述推杆(3)的内部居中开设有用于所述棉绳(4)穿过的通道(11)。
  4. 根据权利要求1所述的一种治疗阴道炎的导管药物型卫生栓，其特征在于：所述外管(1)的管身靠近其为开口结构的一端还一体设有缩口部(7)，且所述外管(1)为开口结构的一端端部还一体设有喇叭状限位圈(8)。
  5. 根据权利要求4所述的一种治疗阴道炎的导管药物型卫生栓，其特征在于：所述缩口部(7)的内径与所述内管(2)的外径相等。
  6. 根据权利要求1所述的一种治疗阴道炎的导管药物型卫生栓，其特征在于：所述推杆(3)远离所述内管(2)的一端端部一体设有喇叭状挡圈(10)。
  7. 根据权利要求6所述的一种治疗阴道炎的导管药物型卫生栓， 其特征在于：所述喇叭状挡圈(10)的外径大于所述喇叭状限位圈(8)的外径。
  8. 根据权利要求1所述的一种治疗阴道炎的导管药物型卫生栓，其特征在于，所述中药层(6)由如下方法制备：
    取以下原料按重量份称量：一枝黄花2份、苦参2份、生百部1份、土槿皮1份、蛇床子1份、地肤子1份、白鲜皮1份、炒黄柏1份和羊蹄根1份；
    S1、将称量好的一枝黄花、苦参、生百部、土槿皮、蛇床子、地肤子、白鲜皮、炒黄柏和羊蹄根清洗干净后烘干并磨粉，制得药材粉末；
    S2、将步骤S1制得的药材粉末置入300ml具塞磨口锥形瓶中，加入95％乙醇150ml，在室温保持在25-30℃的条件下超声提取60-80min，采用1um微孔滤膜过滤，制得提取物滤液；
    S3、将步骤S2制得的提取物滤液加入烧杯中，利用酒精灯进行蒸干，制得提取物浸膏；
    S4、将步骤S3制得的提取物浸膏用甲醇完全溶解后过滤，将滤液转入500ml的容量瓶中定容至刻度线，然后经0.5um微孔滤膜过滤，制得提取物；
    S5、将步骤S4制得的提取物置入内部加有300ml凝胶液的烧杯中，采用玻璃棒搅匀，即制得凝胶状的中药剂；
    S6、将步骤S5制得的中药剂，采用玻璃棒均匀的涂覆在卫生棉条(5)为椭圆形结构的一端外部，即制得中药层(6)。
  9. 根据权利要求8所述的一种中药层的制备方法，其特征在于，所述凝胶液由如下方法制备：
    取以下原料按重量份称量：丙烯酸交联树脂10-12份、三乙醇胺12-14份、甘油60-80份、平平加50-60份、亚硫酸氢钠0.5-1份、依地酸二钠0.5-1份、月桂氮酮8-10份和蒸馏水300-500份；
    a、在常温下将三乙醇胺、甘油、平平加、蒸馏水、亚硫酸氢钠和依地酸二钠以及月桂氮酮加入烧杯中，利用玻璃棒搅拌均匀直至无固体存在；
    b、在搅拌的情况下缓慢加入丙烯酸交联树脂，直至丙烯酸交联树脂完全溶解，制得凝胶液。
  10. 一种权利要求1所述的治疗阴道炎的导管药物型卫生栓的制备方法，其特征在于，包括如下步骤：
    第一步、利用注塑机制备聚乙烯材质的外管(1)和聚乙烯材质的内管(2)以及聚乙烯材质的推杆(3)，所述注塑机的喷嘴温度为170-180℃、模具温度为30-40℃、注射压力为50-100MPa、注射时间为15-20s、冷却时间12-16s、螺杆转速为30-50rpm；
    第二步、到市面上直接采购一端带有棉绳(4)且一端为椭圆形结构的卫生棉条(5)，采用玻璃棒均匀地在卫生棉条(5)为椭圆形结构的一端外部涂覆中药层(6)；
    第三步、将涂覆有中药层(6)的卫生棉条(5)插入外管(1)的内部；
    第四步、将推杆(3)的一端采用胶水封装在内管(2)的一端，然后将棉绳4依次穿过内管(2)与推杆(3)，再将推杆(3)与内管(2)的组装体安插在外管(1)的内部，并使得内管(2)的一端与卫生棉条(5)的一端相抵触，推杆(3)保持在外管(1)的外部，即制得该治疗阴道炎的导管药物型卫生栓。
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