WO2019098352A1 - Composition cosmétique, méthode de criblage, et méthode cosmétique - Google Patents

Composition cosmétique, méthode de criblage, et méthode cosmétique Download PDF

Info

Publication number
WO2019098352A1
WO2019098352A1 PCT/JP2018/042581 JP2018042581W WO2019098352A1 WO 2019098352 A1 WO2019098352 A1 WO 2019098352A1 JP 2018042581 W JP2018042581 W JP 2018042581W WO 2019098352 A1 WO2019098352 A1 WO 2019098352A1
Authority
WO
WIPO (PCT)
Prior art keywords
extract
ipl
cosmetic composition
acid
agent
Prior art date
Application number
PCT/JP2018/042581
Other languages
English (en)
Japanese (ja)
Inventor
佐藤　康成
由佳 杉原
Original Assignee
ロート製薬株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ロート製薬株式会社 filed Critical ロート製薬株式会社
Priority to JP2019554433A priority Critical patent/JPWO2019098352A1/ja
Publication of WO2019098352A1 publication Critical patent/WO2019098352A1/fr
Priority to JP2024011621A priority patent/JP2024045354A/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706—Algae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Definitions

  • the present invention relates to cosmetic compositions, screening methods, cosmetic methods and IPL radiation-like agents.
  • IPL Intelligent Pulse Light
  • Photofacial registered trademark
  • LiLight Lienis One
  • IPL refers to light in a wide wavelength range that is cut short wavelength harmful to the skin such as ultraviolet light.
  • the light of a plurality of wavelengths in a wavelength range of 500 nm to 1200 nm which widely includes visible light and infrared light.
  • various symptoms can be effectively improved.
  • a filter according to the application light in these wavelength ranges can be used to limit the wavelength range and waveform, and irradiation can be performed according to skin conditions. It is said that this treatment is effective for the reduction of firmness, the opening of pores, the color unevenness of the skin, the dullness and the like, and is also effective for the alleviation of the aging symptoms of the entire face.
  • the IPL contains light of a plurality of wavelengths, it is possible to irradiate the whole face with multiple irradiations as described above, instead of local irradiation such as only spot and hokuro as in conventional laser treatment. It is believed that the problem can be effectively improved.
  • the present invention has been made in view of such a situation, and it elucidates the mechanism of action of light treatment and sufficiently exerts a skin condition improving effect on skin whitening, anti-aging, etc., as with IPL irradiation. And, it is an object of the present invention to provide a new idea cosmetic composition which can be easily used by many users, and a new cosmetic method using it.
  • IPL irradiation to epidermal cells suppresses the expression of genes involved in melanin synthesis and melanosome transport, and genes involved in turnover. It was found that expression was promoted. That is, it is considered that the whitening mechanism by IPL irradiation is to act on the above-mentioned genes involved in melanin synthesis, melanosome transport and turnover, and by using this finding, the composition for external use such as cosmetics is similar to IPL irradiation.
  • the gist of the present invention is as follows.
  • a cosmetic composition containing an IPL radiation-like agent [2] The cosmetic composition according to [1], wherein the IPL irradiation-like agent at least contains a plant extract containing flavonoid as an active ingredient. [3] The above plant extract is Cucurbitaceae, Asteraceae, Leguminosae, Rosaceae, Salixaceae, Salixaceae, Fernaceae, Citrus Department, Citrusaceae, Anchovyaceae, Anchovyaceae, Acacia, Asperiaceae, Monimimiaceae, Aescariaceae, The cosmetic composition according to [2], which is an extract of at least one kind of plant selected from the group consisting of a family of plants belonging to the family Laminaceae, the family Laminaceae, a family of mallows and a family of ginger.
  • the melanin related molecule is at least one selected from the group consisting of OCA2, SLC45A2 and RAB27A2.
  • the plant extract is an eggplant extract, an artichoke extract, a licorice root extract, a bilberry fruit extract, a black rosewood bark extract, a meria azalea lacta leaf extract, a mandarin orange peel extract, a yukinoshita extract, a horse mackerel seed extract, a borage seed extract
  • the cosmetic composition according to any one of the above.
  • any one of [1] to [7], which contains at least one member selected from the group consisting of a turnover accelerator (excluding the above-mentioned IPL irradiation-like active agent), an anti-glycation component and a whitening active component A cosmetic composition according to any one of the preceding claims. [9] The cosmetic composition according to any one of [1] to [8], which is for skin tone improver. [10] A screening method of a component for improving skin tone, comprising screening a component effective for improving skin tone by using a gene whose expression is changed by irradiating IPL to skin cells as an index.
  • the screening method according to [10] which comprises at least the steps of allowing a test substance to act on skin culture cells, and measuring the gene expression in the skin culture cells.
  • a cosmetic method for improving or improving the skin condition which comprises using an IPL irradiation-like agent.
  • An IPL radiation-like active agent comprising, as an active ingredient, at least one plant extract selected from the group consisting of Tambrissa tricophila leaf extract, rosemary extract, burdock extract, and altea extract.
  • An IPL irradiation-like agent comprising, as an active ingredient, at least one seaweed extract selected from the group consisting of brown algae, red algae, green algae and blue algae.
  • a cosmetic composition of a novel idea that sufficiently achieves the same skin condition improving effect as IPL irradiation with respect to skin whitening, anti-aging, etc. and can be easily used by many users. Can be provided. In addition, new cosmetic methods using it can also be provided.
  • the cosmetic composition of the present invention contains an IPL radiation-like agent.
  • the IPL irradiation-like agent refers to a composition capable of giving the same effect as when the subject is irradiated with IPL. This is a composition that can replace light treatment such as IPL radiation, ie a cosmetic composition for IPL radiation substitution.
  • an IPL irradiation-like active agent some effects may be given among the effects obtained by irradiating IPL to a subject.
  • the cosmetic composition of the present invention is effective even if it is used alone, but it is also possible to improve the effect of IPL irradiation and maintain it for a long time by combining it with the light treatment such as IPL irradiation.
  • the effects obtained by irradiating the subject with IPL include, for example, the expression regulation effect of melanin-related molecules in skin cells, the skin whitening effect of all faces, and the improvement effect of skin tone.
  • improvement effects improvement effect of skin tone
  • melanin related molecules include OCA2, SLC45A2, RAB27A2, HB-EGF and the like.
  • expression of OCA2, SLC45A2 and RAB27A2 is regulated in a repressing direction by IPL irradiation.
  • the cosmetic composition of the present invention may be a cosmetic composition for suppressing gene expression of at least one selected from the group consisting of OCA2, SLC45A2 and RAB27A2, or a cosmetic composition for promoting gene expression of HB-EGF.
  • the cosmetic composition of the present invention can be said to be a cosmetic composition for skin tone improvement and / or skin tone improvement similar to IPL irradiation because it suppresses or promotes the above-mentioned gene expression.
  • the cosmetic composition of the present invention may contain other optional components in addition to the above IPL radiation-like active agent as long as the effects of the present invention are not impaired.
  • the following describes the IPL radiation-like agent and other optional components.
  • the IPL irradiation-like agent is not particularly limited as long as it is a substance that can give the same effect as when IPL irradiation is given to a subject, but, for example, various plant extracts etc. are effective What is contained as a component is mentioned, and it is preferable that it is a thing which at least contains the plant extract containing flavonoid. Moreover, it is also preferable that it is a thing containing a seaweed extract at least.
  • Examples of plant extracts containing flavonoids include Cucurbitaceae, Asteraceae, Leguminosae, Rosaceae, Salixaceae, Salixaceae, Neridaceae, Citrusaceae, Citrusaceae, Pisidiomycidae, Salamanders, Asinaceae, Monimimiaceae, Aquilinaceae Extracts of plants such as azaleas, botans, mints, mallows, gingers and the like can be mentioned.
  • amacha persimmon extract for example, amacha persimmon extract, artichoke extract, licorice root extract, bilberry fruit extract, white syllable bark extract, melia azalea lacta leaf extract, mandarin orange peel extract, yukinoshita extract, horse mackerel seed extract, borage Examples thereof include fruit extract, hop flower extract, Tambrissa tricophila leaf extract, Hybodaidai flower extract, hydrolysed soybean peptide, white willow bark extract, lice tree extract, rosemary extract, burdock extract, altea extract and the like.
  • a leaf, a flower, a fruit, a root, a stem, a skin, a branch, a fruit, a peel, a seed etc. are mentioned, for example.
  • a plant material may be used as it is or may be dried and used. Plant materials can also be used after being crushed. Moreover, you may use the plant extract marketed as a cosmetics raw material etc.
  • seaweeds used for the above seaweed extract include seaweeds such as brown algae (Gagome kombu, Risei ibu, mitsuishi kombu, macombe, naga kombu, wakame etc.), red algae (eg Tengusa etc.), green algae (Aonori etc.), blue-green algae (spyrulina etc.) And the like extracts.
  • the seaweed raw material may be used as it is or may be dried and used. Plant materials can also be used after being crushed.
  • These seaweeds may be used alone or in combination of two or more. Among these, from the viewpoint of being excellent in the effect of promoting the expression of melanin-related molecules, extracts of brown algae are preferable, extracts of kelp are more preferable, and extracts of gagome comb are more preferable.
  • the melanin-related molecules from the viewpoint of being excellent in the effect of reducing the expression of the OCA2 gene, particularly, artichoke extract, scutellaria root fruit extract, amacha mulberry extract, hydrolyzed soybean peptide (hydrolyzed soybean protein), licorice root
  • artichoke extract scutellaria root fruit extract, amacha mulberry extract, hydrolyzed soybean peptide (hydrolyzed soybean protein), licorice root
  • the extract, the neubara fruit extract, the tambrissa tricophila leaf extract, and the pufferfish flower extract are preferable, and the artichoke extract, the bilberry fruit juice extract, the licorice root extract, and the neurala fruit extract are more preferable.
  • melanin-related molecules particularly from the viewpoint of being excellent in reducing the expression of the SLC45A2 genera extract, licorice root extract, Neubara fruit extract, artichoke extract, hydrolyzed soybean peptide, white willow bark extract, Melia Azadirachta Leaf extract, mandarin orange peel extract, Yukinoshita extract, horse mackerel seed extract, and flower extract are preferable, and amacha mulberry extract, licorice root extract and neubara fruit extract are more preferable.
  • melanin-related molecules particularly from the viewpoint of being excellent in the effect of reducing the expression of RAB27A2, amachar extract, artichoke extract, hydrolyzed soy peptide, licorice root extract, Neubara fruit extract, Yukinoshita extract, Horse mackerel seed extract, tan Preferred are Brissatricophila leaf extract, Fubodaiji flower extract and Izayoibara extract.
  • melanin-related molecules from the viewpoint of the excellent effect of reducing the gene expression of any two or more of OCA2, SLC45A2 and RAB27A2, amacha mulle extract, artichoke extract, hydrolyzed soy peptide, licorice root extract, Neubara fruit extract, Yukinoshita Extract, horseradish seed extract, pufferfish flower extract, white syllable bark extract, mandarin orange peel extract, and Tamburissa Trichophila leaf extract are preferable, and from the viewpoint of being excellent in the effect of reducing the expression of all three genes, Artichoke extract, hydrolyzed soybean peptide, licorice root extract, Neubara fruit extract, Yukinoshita extract, Horse mackerel seed extract, Hybodaige flower extract is more preferable
  • rosemary extract from the viewpoint of being excellent in the effect of promoting the expression of the HB-EGF gene, rosemary extract, seaweed extract, altea extract, albino fruit extract and burdock extract are preferable, seaweed extract,retea extract, Rosemary extract is more preferred.
  • amacha spruce extract as the above-mentioned plant extract in the cosmetic composition of the present invention, amacha spruce extract, artichoke extract, licorice root extract, neubara fruit extract, black radish bark extract, melia azalacilla leaf extract Among them, mandarin orange peel extract, Yukinoshita extract, horseradish seed extract, scutellaria root fruit extract, hop flower extract, Tambrissa tricophila leaf extract, rosemary extract and altea extract are preferable.
  • a brown-alga extract is preferable, a kelp extract is more preferable, and a gagome kombu extract is further more preferable.
  • the content of the IPL irradiation-like agent in the cosmetic composition of the present invention is 0.0001% to 20% by weight when the IPL irradiation-like agent is the plant extract, 0.001 weight % To 10% by weight is preferable, 0.01% to 5% by weight is more preferable, and 0.05% to 3% by weight is further preferable.
  • the cosmetic composition of the present invention may contain the above-mentioned plant extract singly or in combination of two or more. When the cosmetic composition of the present invention contains two or more plant extracts, the total content of the two or more plant extracts is taken as the content of the plant extract.
  • the cosmetic composition unlike the conventional whitening mechanism by tyrosinase activity inhibition etc., has an effect of increasing skin tone by directly acting on genes involved in melanin synthesis and melanosome transport that determine whiteness of the skin. (Skin tone improvement effect).
  • skin tone improvement improves stains, buckwheat, skin dullness and pigmentation associated with aging, and brings it closer to a more natural and even skin color (skin tone improvement) as well as the original skin color. It also includes raising the skin tone of dark skin.
  • a whitening active component for example, a turnover accelerator (except for the IPL irradiation-like active agent of the present invention), an antiglycation component, an antioxidant component, an antiaging component, an antiinflammatory agent Agent, refreshing agent, disinfectant, vitamins, organic acid, moisturizing component, polyhydric alcohol, scrub agent, ultraviolet absorbing component, ultraviolet scattering component, astringent component, peptide or derivative thereof, amino acid or derivative thereof, cleansing component, keratin Soft components, cell activation components, circulation promoting action components and the like can be mentioned.
  • these components may be used alone or in combination of two or more.
  • whitening active ingredients examples include tocopherol, vitamin C and derivatives thereof, arbutin, kojic acid, placenta, ellagic acid, nicotinamide, tranexamic acid and derivatives thereof, hydroquinone, Lucinol (registered trademark), and potassium 4-methoxysalicylic acid. Salts, linoleic acid and derivatives thereof, and the like.
  • turnover promoting agent examples include vitamins to be described later, keratin softness component, cell activation component, blood circulation promoting component and the like.
  • anti-glycation component examples include plant extracts such as budgera akisilalis leaf extract, evening primrose oil, fruits of Amlar, fruit juice or extracts thereof, L-arginine, L-lysine, hydrolysed casein, hydrolyzable tannin , Carnosine and the like.
  • antioxidant component examples include components derived from plants (eg, grape, ginseng, comfrey etc.); proanthocyanidin, tocopherol and derivatives thereof, ascorbic acid and derivatives thereof, hesperidin and derivatives thereof, ergothioneine, sulfite Examples include sodium hydrogen, erythorbic acid and its salts, flavonoids, glutathione and the like.
  • antiaging component examples include hydrolyzed soybean protein, retinoid (retinol and derivatives thereof, retinoic acid, and retinal and the like), pangamic acid, kinetin, ursolic acid, turmeric extract, sphingosine derivative, silicon, silicic acid, N- Methyl-L-serine, mevalonolactone and the like can be mentioned.
  • anti-inflammatory agent examples include allantoin and derivatives thereof, glycyrrhetinic acid and derivatives thereof, glycyrrhizinic acid and derivatives thereof, salicylic acid derivatives, aminocaproic acid, azulene and derivatives thereof, zinc oxide, tocopherol acetate and the like.
  • terpenes such as menthol, camphor, geraniol and the like (these may be d-form, l-form or dl-form); Eucalyptus oil, bergamot oil, peppermint oil, coolmint oil, Examples include essential oils such as spearmint oil and peppermint oil.
  • germicides examples include isopropylmethylphenol, salicylic acid, benzalkonium chloride, ethanol, benzethonium chloride, gluconic acid and derivatives thereof, Photosensitizer No. 101, Photosensitizer No. 201, parabens, phenoxyethanol, piroctoramine, miconazole and the like.
  • the above-mentioned vitamins may be any of water-soluble vitamins and oil-soluble vitamins, for example, vitamin B6s, pantothenic acids, nicotinic acids, vitamin B1s, vitamin B2s, biotins folates, vitamin B12s, Examples thereof include water-soluble vitamin C, oil-soluble vitamin C, vitamin K, and vitamin-like agents such as ferulic acid.
  • organic acids examples include gluconic acid, aspartic acid, aminoethylsulfonic acid, citric acid, glutamic acid, succinic acid, oxalic acid, fumaric acid, propionic acid, malic acid, salicylic acid, glycolic acid, phytic acid, tartaric acid, acetic acid , Lactic acid, and their salts.
  • salts of mineral acids such as sulfuric acid, hydrochloric acid or phosphoric acid
  • salts of organic acids such as maleic acid or methanesulfonic acid
  • alkali metal salts such as sodium or potassium, alkaline earth metal salts, ammonium salts etc.
  • the moisturizing component examples include high molecular weight compounds such as sodium hyaluronate, heparin analogue, sodium chondroitin sulfate, collagen, elastin, keratin, chitin, chitosan, proteoglycan and the like; amino acids such as glycine, aspartic acid and arginine; sodium lactate, Natural moisturizing factors such as urea and sodium pyrrolidonecarboxylate; lipids such as ceramide, cholesterol and phospholipids; plant extracts such as chamomile extract, hamamelis extract, tea extract and shiso extract, and polyhydric alcohols such as glycerin and the like.
  • high molecular weight compounds such as sodium hyaluronate, heparin analogue, sodium chondroitin sulfate, collagen, elastin, keratin, chitin, chitosan, proteoglycan and the like
  • amino acids
  • the polyhydric alcohol preferably has 2 to 10 carbon atoms, and examples thereof include glycerin, diglycerin, triglycerin, propylene glycol, dipropylene glycol, 1,3-butanediol, ethylene glycol, diethylene glycol, isoprene glycol, 1 And 3-butylene glycol, sorbitol, xylitol, erythritol, mannitol, pentanediol, hexanediol, octanediol, decanediol, neopentyl glycol and the like.
  • apricot kernel powder for example, apricot kernel powder, almond shell powder, apricot kernel powder, sodium chloride particles, olive kernel powder, dried seawater particles, candelilla wax, walnut shell powder, cherry kernel powder, coral powder, charcoal powder And husk powder, polyethylene powder, silicic acid anhydride and the like.
  • UV absorbing component examples include ethylhexyl methoxycinnamate, hexyl diethylaminohydroxybenzoylbenzoate, bisethylhexyl oxyphenol methoxyphenyl triazine, ethylhexyl triazone, t-butyl methoxy dibenzoyl methane, octocrylene, polysilicone-15, methylene Bisbenzotriazolyl tetramethylbutylphenol, dimethoxybenzylidene dioxoimidazolidine octylate, phenyl benzimidazole sulfonic acid and the like can be mentioned.
  • Examples of the ultraviolet light scattering component include inorganic compounds such as hydrous silicic acid, zinc silicate, cerium silicate, titanium silicate, titanium oxide, zirconium oxide, cerium oxide, titanium oxide, iron oxide, zinc oxide, silicic anhydride, etc.
  • An inorganic compound coated with an inorganic powder such as hydrous silicic acid, aluminum hydroxide, mica or talc, or compounded with a resin powder such as polyamide, polyethylene, polyester, polystyrene or nylon, and further silicone oil or fatty acid aluminum What was processed by salt etc. is mentioned.
  • astringent component examples include alum, zinc sulfate, aluminum chloride, zinc sulfocarbonate, tannic acid and the like.
  • Examples of the peptide or derivatives thereof include keratinolytic peptides, hydrolyzed keratin, collagen, fish-derived collagen, atelocollagen, gelatin, elastin, elastin degrading peptides, collagenolytic peptides, hydrolyzed collagen, hydroxypropyl ammonium chloride hydrolyzed collagen, Elastin-degrading peptide, Conchiolin-degrading peptide, Hydrolyzed conquioline, Silk-proteolytic peptide, Hydrolyzed silk, Lauroyl-hydrolyzed silk sodium, Soy-proteolytic peptide, Hydrolyzed soy protein, Wheat protein, Wheat-proteolytic peptide, Hydrolyzed wheat protein, Caseinolytic peptides, acylated peptides (palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide, etc.) and the like can be mentioned
  • amino acids or derivatives thereof examples include betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, glycine, alanine, phenylalanine, ⁇ -alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, Cystine, methionine, leucine, isoleucine, valine, histidine, taurine, ⁇ -aminobutyric acid, ⁇ -amino- ⁇ -hydroxybutyric acid, carnitine, carnosine, creatine and the like.
  • washing component examples include soaps selected from alkali metal salts such as potassium laurate, potassium myristate, potassium palmitate or potassium stearate, alkanolamide salts or amino acid salts, etc .; cocoylglutamate Na, cocoyl methyltaurine Na Amino acid surfactant such as ether sulfate ester salt such as sodium laureth sulfate ether carboxylate salt such as sodium lauryl ether acetate salt sulfosuccinic acid ester salt such as alkyl sulfosuccinic ester Na such as coconut oil fatty acid monoethanolamide, coconut oil Fatty acid alkanolamides such as fatty acid diethanolamide; monoalkyl phosphate ester salts such as sodium lauryl phosphate, polyoxyethylene lauryl ether sodium phosphate; coconut oil fatty acid amido propyl dime L-aminoacetic acid betaine, lauryl dimethylaminoacetic acid betaine, 2-al
  • keratin softness component examples include lactic acid, salicylic acid, glycolic acid, citric acid, malic acid, fruit acid, phytic acid, urea, sulfur and the like.
  • the cell activation component examples include amino acids such as ⁇ -aminobutyric acid; vitamins such as retinol, thiamine, riboflavin, pyridoxine hydrochloride, and pantothenic acids; ⁇ -hydroxy acids such as glycolic acid and lactic acid; tannin, flavonoid, Saponin, photosensitive element No. 301 and the like can be mentioned.
  • amino acids such as ⁇ -aminobutyric acid
  • vitamins such as retinol, thiamine, riboflavin, pyridoxine hydrochloride, and pantothenic acids
  • ⁇ -hydroxy acids such as glycolic acid and lactic acid
  • tannin, flavonoid, Saponin, photosensitive element No. 301 and the like can be mentioned.
  • Examples of the above-mentioned blood circulation promoting active ingredient include plants (eg, Panax ginseng, hornhead, Arnica, Ginkgo biloba, Ginkgo biloba, Ginkgo biloba, Ginkgo biloba, Ginkgo biloba, Chamomile, Roman chamomile, Carrot, Gentian, Burdock, Rice, Hawthorn, Shiitake, Ginger, Hawthorn, Prunus edulis , Senkyu, assembly, thyme, chopsticks, chimpanzee, chili pepper, touki, toonin, spruce, carrot, garlic, butcherbroom, grape, button, marronie, melissa, yuzu, yokuinin, ryokucha, rosemary, rosehip, chimpo, touki, Ingredients derived from spruce, peach, apricot, walnut, corn etc); acetylcholine, ictamol, cantaristinki, gamm
  • the method for producing the cosmetic composition of the present invention is not particularly limited, and the IPL irradiation-like active agent which is an essential component, other components optionally mixed (the above optional components, the base or carrier described later, additives, etc. ) Can be appropriately selected and blended, and can be produced by a conventional method.
  • the cosmetic composition of the present invention is an approach based on the IPL treatment (light treatment) idea of a cosmetologist and used in expectation of the same effect on the entire face as IPL irradiation.
  • skin whitening and skin tone improvement effects can be obtained.
  • skin tone improvement skin tone improvement
  • the cosmetic composition of the present invention can be used as an alternative to IPL radiation and in combination with IPL radiation.
  • the cosmetic composition of the present invention used for such purpose is, for example, a cosmetic solution, a lotion, an emulsion, a cream, a gel cream, a cosmetic mask (face mask), a cosmetic base, a foundation, a sunscreen, a cleansing agent, etc.
  • the composition for external use can be suitably used, and more preferably, it can be used as a skin care product such as a cosmetic solution, a lotion, an emulsion, a cream, a gel cream and the like.
  • the cosmetic composition of the present invention can be a food composition.
  • This food composition can be suitably used as a health food, a nutritional supplement (including a balanced nutritional diet, a supplement, etc.).
  • a nutritional supplement including a balanced nutritional diet, a supplement, etc.
  • health functional food food for specified health use (including disease risk reduction indication, standard standard type)).
  • composition for external use a composition for external use
  • a base or carrier usually used for cosmetics, medicines, quasi-drugs and its essential components and other optional components described above, etc.
  • it mixes with an additive mentioned later according to a conventional method, and it emulsifies or solubilizes as needed, It can be set as the cosmetic composition of various formulation forms.
  • the base or carrier examples include hydrocarbons such as liquid paraffin, squalane, petrolatum, gelled hydrocarbon (plasti base etc.), ozokerite, ⁇ -olefin oligomer, light liquid paraffin, etc .; methyl polysiloxane, cyclic silicone, modified silicone Silicone oils such as silicone resins; Fats such as coconut oil, olive oil, rice bran oil, shea butter, etc. Waxes such as jojoba oil, milows, candelilla wax, lanolin, etc.
  • hydrocarbons such as liquid paraffin, squalane, petrolatum, gelled hydrocarbon (plasti base etc.), ozokerite, ⁇ -olefin oligomer, light liquid paraffin, etc .
  • methyl polysiloxane cyclic silicone, modified silicone Silicone oils such as silicone resins
  • Fats such as coconut oil, olive oil, rice bran oil, shea butter, etc.
  • Waxes such as jojoba oil, milows
  • the base or carrier described above may be used alone or in combination of two or more.
  • the amount used thereof is appropriately selected from the range known to those skilled in the art.
  • the cosmetic composition of the present invention may be a known additive added to cosmetics, pharmaceuticals, quasi-drugs, as long as the effects of the present invention are not impaired, such as surfactants, antioxidants, colorants, pearls
  • a glossing agent, a chelating agent, a pH adjuster, a preservative, a thickener, etc. can be added.
  • These additives may be used alone or in combination of two or more.
  • the surfactant may be any of nonionic surfactant, cationic surfactant, anionic surfactant, amphoteric surfactant and the like, and examples thereof include sorbitan monoisostearate and sorbitan monolaurate. Sorbitan monopalmitate, sorbitan monostearate, diglycerol sorbitan penta-2-ethylhexyl acid, sorbitan fatty acid esters such as diglycerol sorbitan tetra-2-ethylhexyl acid; propylene glycol fatty acid esters such as propylene glycol monostearate; Cured castors of polyoxyethylene hydrogenated castor oil 40 (HCO-40), polyoxyethylene hydrogenated castor oil 50 (HCO-50), polyoxyethylene hydrogenated castor oil 60 (HCO-60), polyoxyethylene hydrogenated castor oil 80, etc.
  • HCO-40 polyoxyethylene hydrogenated castor oil 40
  • HCO-50 polyoxyethylene hydrogenated castor oil
  • HCO-60 polyoxyethylene
  • antioxidants examples include dibutylhydroxytoluene, butylhydroxyanisole, sorbic acid, sodium sulfite, ascorbic acid, erythorbic acid, L-cysteine hydrochloride and the like.
  • coloring agent an inorganic pigment, a natural pigment
  • chelating agent examples include EDTA ⁇ disodium salt, hydroxyethane diphosphonic acid ⁇ calcium ⁇ disodium salt and the like.
  • pH adjuster examples include inorganic acids (hydrochloric acid, sulfuric acid etc.), organic acids (lactic acid, sodium lactate, citric acid, sodium citrate, sodium citrate, succinic acid, sodium succinate etc.), inorganic bases (potassium hydroxide, hydroxide Sodium etc., organic bases (triethanolamine, diisopropanolamine, triisopropanolamine etc.) and the like.
  • preservative examples include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate, methyl parahydroxybenzoate, phenoxyethanol, capryl hydroxamic acid, pentanediol, hexanediol, octane Alkane diols, such as diol, etc. are mentioned.
  • thickener examples include vinyl thickeners such as polyvinyl alcohol, polyvinyl pyrrolidone and carboxyvinyl polymer, methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose and the like.
  • vinyl thickeners such as polyvinyl alcohol, polyvinyl pyrrolidone and carboxyvinyl polymer, methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose and the like.
  • Cellulose thickeners guar gum, pectin, pullulan, gelatin, locust bean gum, carrageenan, agar, xanthan gum, acrylic acid methacrylic acid alkyl methacrylate copolymer, polyethylene glycol, bentonite, alginic acid, propylene glycol alginate, macrogol, chondroitin sulfate Sodium, hyaluronic acid, sodium hyaluronate, Hydroxyethylmethacrylate / acryloyldimethyltaurinato Na) copolymer, and (ammonium acryloyldimethyltaurate / vinyl pyrrolidone) copolymers and the like.
  • composition for external use The formulation form in the case where the cosmetic composition of the present invention is a composition for external use is not particularly limited, and, for example, a liquid preparation (skin lotion, lotion, serum etc.), cream preparation (milky lotion, cream, gel cream, balm etc.), Gel formulations, jelly formulations, sherbet formulations, aerosol formulations, foam formulations, spray formulations, patches, stick formulations, other ointments, solid formulations and the like can be mentioned. These preparations can be manufactured according to a conventional method, for example, the method described in the 17th revised Japanese Pharmacopoeia General Rules, and the like.
  • agent types such as W / O, O / W, W / O / W, and O / W / O type emulsions can be appropriately selected in consideration of the desired stability, feeling in use, and the like.
  • the patch may be, for example, a non-woven sheet, a gel sheet or the like impregnated with a cosmetic composition, a cosmetic composition, an emulsion composition or the like.
  • the cosmetic composition of the present invention is a food composition
  • the essential components thereof and the other optional components described above, etc. may be used as a base or carrier generally used in food, and, if necessary, fats and oils, emulsifiers, It may be formulated by mixing with food additives such as dispersants, suspending agents, stabilizers, thickeners, sweeteners, colorants, flavors, preservatives, antioxidants, organic acids and the like.
  • the food additive is not limited to the above-described ones and the specific components described later, and can be selected appropriately according to the purpose and necessity.
  • these food additives can be used individually by 1 type or in combination of 2 or more types.
  • other active ingredients can be added to the formulation.
  • the above fats and oils include natural vegetable oils such as peanut oil, cocoa butter, rice germ oil, perilla oil, linseed oil, etc., and hydrogenated oils thereof, glycerides of fatty acids (including medium-chain fatty acids) (glycerides, diglycerides, triglycerides, etc.)
  • glycerides of fatty acids including medium-chain fatty acids
  • the bee wax etc. are mentioned. Among them, beeswax is preferable.
  • emulsifying agent examples include polyethylene glycol, propylene glycol, glycerin, polyhydric alcohol such as sorbitol, sorbitol; glycerin fatty acid ester; sodium carboxymethylcellulose and the like. Among them, glycerin, glycerin fatty acid ester and carboxymethylcellulose sodium are preferable.
  • thickener examples include locust bean gum, guar gum, xanthan gum, tamarind gum, pectin, carrageenan and the like. Among them, xanthan gum is preferred.
  • sucrose, fructose, maltose, erythritol, trehalose, maltitol, licorice extract, stevia processed sweetener, aspartame, acesulfame potassium, sorbitol, xylitol and the like can be mentioned.
  • preservative examples include benzoic acid or a salt thereof, sorbic acid or a salt thereof, butyl parahydroxybenzoate, isobutyl parahydroxybenzoate, isopropyl parahydroxybenzoate, ethyl parahydroxybenzoate, methyl parahydroxybenzoate and the like.
  • ascorbic acid sodium ascorbate, ascorbic acid stearic acid ester, sodium ascorbic acid stearic acid ester, ascorbic acid palmitic acid ester, hydrogen sulfite, sodium hyposulfite, sulfur dioxide, calcium EDTA disodium, erythorbic acid Sodium erythorbate, tocopherol and the like.
  • ascorbic acid, ascorbic acid palmitate ester, and tocopherol are preferable.
  • organic acid examples include citric acid, succinic acid, tartaric acid, aspartic acid, lactic acid, malic acid, malonic acid, fumaric acid and maleic acid.
  • the pH of the cosmetic composition of the present invention is usually 3.0 to 8.0, preferably 3.5 to 7.5.
  • this pH can be adjusted, for example by use of the pH adjuster mentioned later.
  • the present invention also includes a method of screening a skin tone improving component and a method of screening a skin tone improving component.
  • the screening method of the present invention is a method characterized by using a gene whose expression is changed by irradiating IPL to skin cells as an indicator, and a step (1) of causing a test substance to act on skin culture cells, the above-mentioned skin culture At least a step (2) of measuring the gene expression in the cell. According to the screening method of the present invention, it is possible to efficiently obtain a skin tone improving component and a skin tone improving component that can obtain the same effect as when IPL irradiation (phototreatment) is received.
  • the skin culture cell is not particularly limited as long as it is a cell population containing melanocytes.
  • epidermal cells, dermal cells, a cultured skin model and the like can be used.
  • As the above-mentioned cultured skin model use of MEL-300A (MatTek) or EFT-400 (MatTek) is more preferable.
  • the test substance is added to the above-mentioned cultured skin cells and cultured for about 2 to 72 hours. As a negative control, one to which no test substance is added is prepared.
  • Step (2) After the above step (1), cells are recovered, RNA is extracted according to a conventional method, and gene expression is analyzed by a DNA microarray method or the like. The gene expression of each of the group to which the test substance was added and the group to which no test substance was added (negative control) in step (1) is matched. At this time, as a gene to be matched, a gene whose fluctuation has been confirmed to occur by irradiating IPL to skin cells is used. Such genes include, for example, OCA2, SLC45A2, RAB27A2, and HB-EGF. These genes are genes found by the present inventors to be suppressed or promoted in expression by IPL irradiation.
  • the test substance in the addition group of the test substance, it is confirmed whether the expression of each gene fluctuates as in the IPL irradiation. And the test substance which changes expression of these genes similarly to the time of IPL irradiation can be determined as the component for skin tone improvement, and the component for skin tone improvement.
  • the present invention also includes cosmetic methods for improving and improving skin conditions, characterized by using an IPL radiation-like agent.
  • the same effect as IPL irradiation can be obtained by using the IPL irradiation-like active agent, and thus, for example, the effect of improving skin whitening and skin tone can be obtained.
  • the improvement effect (skin tone improvement effect) of aging symptoms such as the dullness of the whole face, texture disorder, fine wrinkles, and telangiectasia can be obtained.
  • the description in the term of the above-mentioned cosmetic composition can be applied as it is as the specific description of the above-mentioned IPL irradiation-like agent.
  • the present invention also includes IPL radiation-like agents containing various plant extracts as active ingredients.
  • the plant extract containing a flavonoid and a seaweed extract are preferable.
  • a plant extract containing the above-mentioned flavonoids amacha persimmon extract, artichoke extract, licorice root extract, bilberry fruit extract, albino bark extract, Melia azalacilla leaf extract, mandarin orange peel extract, yukinoshita extract, horseradish seed
  • seaweed extract examples include brown algae (gagome kombu, lysiensis, mitsushikonbu, maconbu, nagacomb, wakame etc.), red algae (eg tenegusa etc.), green algae (eg Aonori etc.), blue-green algae (spyrulina etc.) etc. preferable.
  • the IPL irradiation-like active agent of the present invention amacha persimmon extract, artichoke extract, licorice root extract, neybara fruit extract, albino bark extract, Meria azadia lacta leaf extract, mandarin orange peel extract, yukinoshita extract, horse mackerel seeds
  • one containing at least one seaweed extract selected from the group consisting of brown algae, red algae, green algae, and blue algae as an active ingredient is preferable, and seaweed extracts of brown algae are preferable. It is more preferable to contain it as an active ingredient.
  • the description of the IPL radiation-like agent in the section of the above cosmetic composition can be applied.
  • the same effect as IPL radiation can be obtained, for example, skin whitening of all faces, skin tone improving effect, all faces dullness, using a cosmetic composition containing this An improvement effect (amelioration effect of skin tone) of aging symptoms such as no firmness, pore appearance and dryness is obtained.
  • the description in the term of the above-mentioned cosmetic composition can be applied as it is as the specific description of the above-mentioned IPL irradiation-like agent.
  • the epidermal model prepared by the above method was irradiated with light (IPL 560 nm) using a filter of ⁇ 560 nm for 3 ms, and then irradiated for 20 ms with another 3 ms, and cells were recovered after 6 hours and 24 hours .
  • IPL irradiation was performed using Photofacial M22 (made by Luminous Corporation).
  • RNA was extracted from each cell according to a conventional method, and gene expression was analyzed by the DNA microarray method.
  • the DNA microarray used Human Gene 2.0 ST Array.
  • OCA2, RAB27A, SLC45A2, and HB-EGF were selected as genes whose expression was changed in epidermal cells by IPL 560 nm irradiation.
  • RNA was extracted by a conventional method, cDNA was synthesized from the RNA by reverse transcription reaction, and the expression amounts of the OCA2, SLC45A2 and RAB27A genes were quantified by quantitative real-time PCR.
  • the ratio to blank was calculated using the obtained value.
  • a blank means the data of the control test by only the culture medium which has not added each extract sample. The results are shown in Tables 1 to 17 below.
  • Test 3 Screening of substances that affect the expression of HB-EGF gene in human keratinocytes Normal human adult epidermal cells (Kurabo: NHEK) using epidermal keratinocyte culture medium (Kurabo: Humedia KG2) The cells were seeded at 40000 cells / well in a 24-well plate (CORNING) and cultured for 1 day. Thereafter, extract samples are prepared with medium to give each concentration, and those which are passed through a filter with a pore size of 0.2 ⁇ m are added at 400 ⁇ l / well to a 24-well plate from which the medium has been removed, and cultured for another 24 hours. The cells were harvested.
  • RNA was extracted by a conventional method, cDNA was synthesized from the RNA by reverse transcription reaction, and the expression level of each gene of HB-EGF was quantified by quantitative real time PCR. The ratio to blank was calculated using the obtained value. In addition, a blank means the data of the control test by only the culture medium which has not added each extract sample. The results are shown in Table 18 below.
  • the cosmetic composition and the cosmetic method of the present invention can also be expected to have an effect (bright skin tone improving effect) to lighten skin with a darker skin tone than originally expected (a cosmetic composition of the present invention can be used as a skin tone improver). Can also be used.
  • the cosmetic composition and the cosmetic method of the present invention can also be expected to have the effect of improving aging symptoms (skin tone improving effect) such as dullness of the entire face, lack of firmness, pore appearance, dryness, etc. it can.
  • Prescription example 1 (Beauty fluid) L-ascorbic acid 10.0 (w / w%) Hydroquinone 0.1 Diethylene glycol monoethyl ether 51.0 Propylene glycol 23.0 Horse mackerel extract 0.1 Neubara Fruit Extract 0.5 Total purified water remaining 100.0%
  • Prescription example 2 (Beauty fluid) 3-O-ethyl ascorbic acid 3.0 (w / w%) Diethylene glycol monoethyl ether 30.0 Propylene glycol 20.0 Glycerin 4.0 Altea extract 1.0 Artichoke extract 10.0 Total purified water remaining 100.0%
  • Prescription example 3 (Skin lotion) Tranexamic acid 1.5 (w / w%) Salicylic acid 0.1 Sodium hyaluronate 0.2 Glycerin 2.0 1,3-butylene glycol 10.0 Polyoxypropylene methyl glucoside 0.2 Acetylated sodium hyaluronate 0.01 Hydroxyethyl cellulose 0.05 Methyl parahydroxybenzoate 0.15 Flavoring agent 0.03 Oil-soluble licorice extract 0.0001 Total purified water remaining 100.0%
  • Prescription example 4 (Skin lotion) Tranexamic acid 1.5 (w / w%) Salicylic acid 0.1 Sodium hyaluronate 0.2 Glycerin 1.0 Diglycerin 0.5 1,3-butylene glycol 5.0 Dipropylene glycol 3.0 Trehalose 0.1 Acetylated sodium hyaluronate 0.01 Hydroxyethyl cellulose 0.05 Methyl parahydroxybenzoate 0.15 Flavoring agent 0.03 Seaweed extract 0.5 Rosemary extract 0.3 Total purified water remaining 100.0%
  • Prescription example 6 (milky lotion) Tranexamic acid 2.0 (w / w%) ⁇ -Arbutin 0.1 Salicylic acid 0.2 Sodium hyaluronate 0.2 Dipropylene glycol 5.0 1,3-butylene glycol 8.0 Glycerin 3.0 Glycerin monostearate 1.0 Carboxy vinyl polymer 0.2 Xanthan gum 0.05 Meadowfoam oil 5.0 Glyceryl tri-2-ethylhexanoate 5.0 Methylpolysiloxane 1.0 Triethanolamine 0.1 Tocopherol 0.1 Acetylated sodium hyaluronate 0.05 Sodium edetate 0.05 Methyl parahydroxybenzoate 0.2 Flavoring agent 0.05 Rosemary extract 0.1 Agetsu extract 0.1 Total purified water remaining 100.0%
  • Prescription example 7 (cream) Nicotinamide 1.0 (w / w%) Glycerin 5.0 1,3-butylene glycol 5.0 Light liquid paraffin 3.0 Acrylic acid methacrylic acid alkyl copolymer 0.3 Arginine 0.3 Polyoxyethylene Cured Castor Oil 0.5 Methyl parahydroxybenzoate 0.2 Melia Azadirachta Leaf Extract 0.5 Mandarin Orange Peel Extract 3.0 Purified water total amount 100.0%
  • Prescription example 8 Tranexamic acid 1.0 (w / w%) Arbutin 3.0 Salicylic acid 0.05 Sodium hyaluronate 0.15 Dipropylene glycol 8.0 Diglycerin 5.0 Glycerin 3.0 Hydroxyethylurea 3.0 Polyoxyethylene sorbitan isostearate 0.5 Glycerin monostearate 0.4 Setostearyl Glucoside ⁇ Setostearyl Alcohol 1.5 Acrylic acid / methacrylic acid alkyl copolymer 0.5 Meadowfoam oil 0.5 Squalane 3.0 Tri (Caprylic / Capric) Glyceryl 1.5 Methylpolysiloxane 1.0 Behenyl alcohol 0.2 Stearyl alcohol 0.3 Xanthan gum 0.2 Sodium hydroxide 0.1 Sodium edetate 0.1 Methyl parahydroxybenzoate 0.2 Flavoring agent 0.1 Ceramide 1 0.01 Ceramide 2 0.01 Ceramide 6 0.01 Rosemary extract 0.001 Yukinoshita extract 0.
  • Prescription example 9 (cosmetic fluid) Nicotinamide 5.0 (w / w%) Glycerin 2.0 1,3-butylene glycol 3.0 Squalane 2.0 Triethylhexanoin 1.0 Carboxy vinyl polymer 0.2 (Acryloyl dimethyl taurine ammonium / vinyl pyrrolidone) Copolymer 0.2 Polyoxyethylene polyoxypropylene butyl ether (17E.O.) (17P.O.) 0.5 Polyoxypropylene methyl glucoside 0.5 Triethanolamine 0.15 Hydrogenated soybean phospholipids 0.5 Methyl parahydroxybenzoate 0.2 Bilberry leaf extract 0.05 Comfrey leaf extract 0.05 Purified water total amount 100.0%
  • Prescription example 10 (cosmetic fluid) Nicotinamide 5.0 (w / w%) Dipropylene glycol 5.0 1,3-butylene glycol 5.0 Light liquid paraffin 2.0 Methyl phenyl polysiloxane 1.0 Xanthan gum 0.5 (PEG-240 / decyltetradeces-20 / HDI) copolymer 1.5 Cholesteryl oleate 0.2 Polyoxyethylene Cured Castor Oil 0.5 Hydrogenated soybean phospholipids 0.2 Pentanediol 1.0 Phenoxyethanol 0.2 Macadamia nut fatty acid phytosteryl 0.1 Himefuuro extract 0.05 Fern root extract 0.05 Purified water total amount 100.0%
  • Prescription example 11 (cream) Nicotinamide 5.0 (w / w%) Glycerin 5.0 1,3-butylene glycol 10.0 1,2-pentanediol 0.5 Botanical squalane 5.0 Tri (Capryl capric acid) Glyceryl 1.0 Methylpolysiloxane 1.0 Carboxy vinyl polymer 0.4 Xanthan gum 0.05 Polyoxyethylene sorbitan monostearate 1.5 Sorbitan monostearate 0.5 Polyoxyethylene cetyl ether 0.2 Glycerin mono 2-ethylhexyl ether 0.5 Ceramide 2 0.0005 Ceramide 6 II 0.00005 Seaweed extract (1) 2.0% Altea extract 0.01 pH adjuster appropriate amount purified water total amount 100.0%
  • Prescription example 12 Ascorbyl tetra 2-hexyldecanoate 0.1 (w / w%) Trimethylglycine 1.0 2-Methylhexyl paramethoxycinnamate 10.0 Decamethylcyclopentasiloxane 20.0 Octyl palmitate 10.0 Polyoxyethylene / methylpolysiloxane copolymer 3.0 Methylhydrogenpolysiloxane treated low temperature calcined zinc oxide 15.0 Polyalkyl acrylate 5.0 Glycerin 5.0 Absolute ethanol 5.0 1,3-butylene glycol 3.0 Panthenol 0.1 Flavoring agent 0.1 Ceramide 2 0.001 Ceramide 3 0.001 Ceramide 6 0.001 Plantain Seed Extract 0.01 Beak Passion Fruit Extract 0.1 Total purified water remaining 100.0%
  • Prescription example 13 (cleansing) L-ascorbic acid 2-glucoside 0.1 (w / w%) PEG-20 Glyceryl Triisostearate 12.0 Polyglyceryl isostearate-10 8.0 Ethylhexyl palmitate 30.0 Triethyl hexanoin 20.0 Mineral oil 25.0 Diphenylsiloxyphenyl trimethicone 1.0 Hop flower extract 0.0001 Total purified water remaining 100.0%
  • Prescription example 14 (cleansing) L-ascorbic acid 2-glucoside 0.1 (w / w%) PEG-20 Glyceryl Triisostearate 12.0 Polyglyceryl isostearate-10 8.0 Ethylhexyl palmitate 28.0 Triethyl hexanoin 20.0 Mineral oil 20.0 Diphenylsiloxyphenyl trimethicone 1.0 Seaweed extract 0.0001 Altea extract 0.0001 Total purified water remaining 100.0%
  • Formulation example 15 (soft capsule: food composition)
  • the unit of numerical values in the following formulation examples of food compositions is "parts by weight”.
  • Capsule Contents Evening Primrose Oil 120 Hydrolyzable tannin 20 Hydrolyzed soy protein 20 Lotus germ extract 5 Ceramide 3 Hyaluronic acid 0.5 CoQ10 2 Hematococcus alga pigment extract (containing astaxanthin) 4 Vitamin C 1 Glycerin fatty acid ester 10
  • Bee wax 5 Capsule film Gelatin 92 Pull Run 3 Glycerin 35 Colorant 3
  • Prescription example 16 (cosmetic drink) unit (mg) Fern extract 180 Placenta extract 180 Collagen peptide 1000 Artichoke extract 50 Proteoglycan 20 Horse mackerel extract 20 Polysorbate 80 0.1 Erythritol 3 Agar 0.5 Water candy 0.6 Fructose 2 Acidulant 0.5 Flavoring agent 0.1 Water 86.1 Total daily intake (mg) 1542.9
  • Prescription example 17 (cosmetic drink) unit (mg) Seaweed extract 180 Placenta extract 180 Collagen peptide 1000 Proteoglycan 20 Rosemary extract 40 Polysorbate 80 0.1 Erythritol 3 Agar 0.5 Water candy 0.6 Fructose 2 Acidulant 0.5 Flavoring agent 0.1 Water 103.2 Daily intake total (mg) 1530.0

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Birds (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Botany (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Cosmetics (AREA)
  • Dermatology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention aborde le problème consistant à fournir : une nouvelle composition cosmétique qui présente un effet d'amélioration de l'état de la peau suffisant qui est au moins comparable à une irradiation de lumière pulsée intense (LPI), en matière de blanchiment de la peau, d'effet anti-âge et similaire, et qui est facile à utiliser pour de nombreux utilisateurs ; et une nouvelle méthode cosmétique qui utilise celle-ci. Cette composition cosmétique comprend un agent qui présente une action de type irradiation de LPI. En outre, cette composition cosmétique présente un effet comparable à la photothérapie, et peut être utilisée comme alternative à l'irradiation de LPI. De plus, il est préférable que l'agent présentant une action de type irradiation de LPI dans cette composition cosmétique comprenne un extrait végétal comprenant des flavonoïdes, et/ou un extrait d'algue.
PCT/JP2018/042581 2017-11-17 2018-11-16 Composition cosmétique, méthode de criblage, et méthode cosmétique WO2019098352A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2019554433A JPWO2019098352A1 (ja) 2017-11-17 2018-11-16 美容組成物、スクリーニング方法及び美容方法
JP2024011621A JP2024045354A (ja) 2017-11-17 2024-01-30 美容組成物、スクリーニング方法及び美容方法

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2017222292 2017-11-17
JP2017-222292 2017-11-17
JP2018146143 2018-08-02
JP2018-146143 2018-08-02

Publications (1)

Publication Number Publication Date
WO2019098352A1 true WO2019098352A1 (fr) 2019-05-23

Family

ID=66539781

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2018/042581 WO2019098352A1 (fr) 2017-11-17 2018-11-16 Composition cosmétique, méthode de criblage, et méthode cosmétique

Country Status (2)

Country Link
JP (2) JPWO2019098352A1 (fr)
WO (1) WO2019098352A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021014438A (ja) * 2019-07-16 2021-02-12 日本メナード化粧品株式会社 カテプシンｖ活性促進剤及びｇａｔａ−３産生抑制剤
CN112402269A (zh) * 2020-11-30 2021-02-26 瑞兰德宝生物医药有限公司 一种保湿修复面膜及其制备方法
JP2021155393A (ja) * 2020-03-25 2021-10-07 大正製薬株式会社 ミネラル代謝異常抑制剤
WO2021215423A1 (fr) * 2020-04-24 2021-10-28 株式会社 資生堂 Préparation de produit cosmétique

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003503705A (ja) * 1999-06-29 2003-01-28 ニューヨーク・ユニバーシティ メラニン形成に影響を与える化合物に関するスクリーニング方法
WO2008026507A1 (fr) * 2006-09-01 2008-03-06 Sapporo Breweries Limited Agent de blanchiment de la peau
WO2009113446A1 (fr) * 2008-03-11 2009-09-17 株式会社資生堂 Procédé de blanchiment de la peau et procédé de criblage pour facteurs de suppression de formation de rides et/ou facteurs d'élimination de rides
JP2011504498A (ja) * 2007-11-19 2011-02-10 スティーフェル ラボラトリーズ インコーポレイテッド 局所美白化粧品組成物およびその使用方法
JP2012126654A (ja) * 2010-12-13 2012-07-05 Kao Corp ベオミセス酸含有抽出物の製造方法
JP2012520349A (ja) * 2010-07-22 2012-09-06 ザ プロクター アンド ギャンブル カンパニー フトコンブの抽出物を用いた色素過剰スポットの外観を改善するための方法
JP2012171960A (ja) * 2011-02-18 2012-09-10 Amorepacific Corp 皮膚美白用化粧料組成物
WO2014103475A1 (fr) * 2012-12-27 2014-07-03 株式会社林原 Composition antivieillissement pour l'extérieur de la peau et son procédé de production
JP2014532672A (ja) * 2011-10-29 2014-12-08 メルク パテント ゲーエムベーハー 光線療法に用いる美白剤
JP2016027034A (ja) * 2014-06-30 2016-02-18 ロート製薬株式会社 外用組成物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4562466B2 (ja) * 2004-09-09 2010-10-13 一丸ファルコス株式会社 ニーム抽出物の製造方法及びこれを含有する低刺激性化粧料組成物
JP2006290749A (ja) * 2005-04-06 2006-10-26 Ichimaru Pharcos Co Ltd メラニン生成抑制剤
JP2009108015A (ja) * 2007-11-01 2009-05-21 Pias Arise Kk 伸展刺激介在メラニン生成抑制剤
JP5970148B2 (ja) * 2008-09-12 2016-08-17 丸善製薬株式会社 チロシナーゼ活性阻害剤、メラニン産生抑制剤、及びＳＣＦｍＲＮＡ発現抑制剤
JP2011020965A (ja) * 2009-07-17 2011-02-03 Maruzen Pharmaceut Co Ltd 化粧料キット及び化粧方法
JP2011032182A (ja) * 2009-07-30 2011-02-17 Kose Corp 一重項酸素消去剤ならびにこれを含有する皮膚外用剤および化粧料
CN106214576A (zh) * 2016-08-30 2016-12-14 陈燕兰 一种美白祛斑护肤品及其制备方法与应用

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003503705A (ja) * 1999-06-29 2003-01-28 ニューヨーク・ユニバーシティ メラニン形成に影響を与える化合物に関するスクリーニング方法
WO2008026507A1 (fr) * 2006-09-01 2008-03-06 Sapporo Breweries Limited Agent de blanchiment de la peau
JP2011504498A (ja) * 2007-11-19 2011-02-10 スティーフェル ラボラトリーズ インコーポレイテッド 局所美白化粧品組成物およびその使用方法
WO2009113446A1 (fr) * 2008-03-11 2009-09-17 株式会社資生堂 Procédé de blanchiment de la peau et procédé de criblage pour facteurs de suppression de formation de rides et/ou facteurs d'élimination de rides
JP2012520349A (ja) * 2010-07-22 2012-09-06 ザ プロクター アンド ギャンブル カンパニー フトコンブの抽出物を用いた色素過剰スポットの外観を改善するための方法
JP2012126654A (ja) * 2010-12-13 2012-07-05 Kao Corp ベオミセス酸含有抽出物の製造方法
JP2012171960A (ja) * 2011-02-18 2012-09-10 Amorepacific Corp 皮膚美白用化粧料組成物
JP2014532672A (ja) * 2011-10-29 2014-12-08 メルク パテント ゲーエムベーハー 光線療法に用いる美白剤
WO2014103475A1 (fr) * 2012-12-27 2014-07-03 株式会社林原 Composition antivieillissement pour l'extérieur de la peau et son procédé de production
JP2016027034A (ja) * 2014-06-30 2016-02-18 ロート製薬株式会社 外用組成物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YAMAGUCHI KYOKO: "The Cutting Edge of Genomic Anthropology- Evolution of skin color on the basis of gene", IGAKU NO AYUMI, vol. 249, no. 8, 24 May 2014 (2014-05-24), pages 716 - 719 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021014438A (ja) * 2019-07-16 2021-02-12 日本メナード化粧品株式会社 カテプシンｖ活性促進剤及びｇａｔａ−３産生抑制剤
JP7316647B2 (ja) 2019-07-16 2023-07-28 日本メナード化粧品株式会社 カテプシンｖ活性促進剤及びｇａｔａ－３産生抑制剤
JP2021155393A (ja) * 2020-03-25 2021-10-07 大正製薬株式会社 ミネラル代謝異常抑制剤
WO2021215423A1 (fr) * 2020-04-24 2021-10-28 株式会社 資生堂 Préparation de produit cosmétique
CN112402269A (zh) * 2020-11-30 2021-02-26 瑞兰德宝生物医药有限公司 一种保湿修复面膜及其制备方法

Also Published As

Publication number Publication date
JP2024045354A (ja) 2024-04-02
JPWO2019098352A1 (ja) 2021-01-14

Similar Documents

Publication Publication Date Title
CN104000752B (zh) 用于干细胞保护的姜提取物
CN114306171B (zh) 局部皮肤用组合物及其用途
JP5113371B2 (ja) シロキクラゲ由来水溶性多糖類の加水分解物、及びこれを含有する抗酸化剤並びに化粧料又は皮膚外用剤、食品
CN106794124B9 (zh) 含不饱和二羧基脂肪酸的混合物的活性成分，含所述成分的组合物和美容或皮肤学用途
TW201438757A (zh) 抗老化用之皮膚外用組成物及其製造方法
WO2019098352A1 (fr) Composition cosmétique, méthode de criblage, et méthode cosmétique
CN111032009B (zh) 美白剂、美白用皮肤外用剂以及皮肤的美白方法
JPWO2007013690A1 (ja) 顧客に適する局所塗布剤とサプリメントとを提供する方法
CN103025307B (zh) 菊苣酸及衍生物用于调节皮肤色素沉着的用途
JP2005220084A (ja) アセロラ種子抽出物含有組成物
JP7461876B2 (ja) デビルズクロー抽出物、それを含有する各種組成物及びデビルズクロー抽出物の製造方法
JP2007210915A (ja) 皮膚外用剤
JP2004010526A (ja) 皮膚外用剤
JP2012092078A (ja) ヒドロキシニコチン酸又はその誘導体を含有する化粧料又は皮膚外用剤
JP2016108253A (ja) スキンケア化粧品組成物
JP3987793B2 (ja) 皮膚外用剤
JP2011178770A (ja) 皮膚の色素沈着を抑制する組成物およびその利用
US10660846B2 (en) Method and composition for lightening skin using a cell culture extract
JP2004051492A (ja) 老化防止剤又は細胞賦活剤及びこれを含有する皮膚外用剤
JP5602456B2 (ja) アスコルビン酸誘導体
JP2013184942A (ja) 抗酸化剤及びｄｎａ損傷抑制剤
JP2004168732A (ja) 活性酸素消去剤、ヒアルロン酸合成促進・分解抑制剤およびアクアポリン合成促進剤
JP2016047807A (ja) マンダリンオレンジ抽出物含有アデノシン三リン酸フォスファターゼ発現誘導剤
JP2013032331A (ja) 脂質産生抑制剤、皮脂産生抑制剤およびトリアシルグリセロール産生抑制剤
JP2007137848A (ja) 化粧料及び皮膚外用剤

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 18877430

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2019554433

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 18877430

Country of ref document: EP

Kind code of ref document: A1