WO2019095089A1 - Composition de détergent textile antimicrobienne granulaire - Google Patents

Composition de détergent textile antimicrobienne granulaire Download PDF

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Publication number
WO2019095089A1
WO2019095089A1 PCT/CN2017/110782 CN2017110782W WO2019095089A1 WO 2019095089 A1 WO2019095089 A1 WO 2019095089A1 CN 2017110782 W CN2017110782 W CN 2017110782W WO 2019095089 A1 WO2019095089 A1 WO 2019095089A1
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WO
WIPO (PCT)
Prior art keywords
laundry detergent
water
composition
granular laundry
detergent composition
Prior art date
Application number
PCT/CN2017/110782
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English (en)
Inventor
Qian Gao
Chunpeng Jiang
Yuxiang Liu
Original Assignee
The Procter & Gamble Company
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Publication date
Application filed by The Procter & Gamble Company filed Critical The Procter & Gamble Company
Priority to CN201780096449.4A priority Critical patent/CN111315858B/zh
Priority to PCT/CN2017/110782 priority patent/WO2019095089A1/fr
Publication of WO2019095089A1 publication Critical patent/WO2019095089A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66—Non-ionic compounds
    • C11D1/83—Mixtures of non-ionic with anionic compounds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
    • C11D17/06—Powder; Flakes; Free-flowing mixtures; Sheets
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/0005—Other compounding ingredients characterised by their effect
    • C11D3/0047—Other compounding ingredients characterised by their effect pH regulated compositions
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/24—Organic compounds containing halogen
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/02—Anionic compounds
    • C11D1/12—Sulfonic acids or sulfuric acid esters; Salts thereof
    • C11D1/22—Sulfonic acids or sulfuric acid esters; Salts thereof derived from aromatic compounds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/02—Anionic compounds
    • C11D1/12—Sulfonic acids or sulfuric acid esters; Salts thereof
    • C11D1/29—Sulfates of polyoxyalkylene ethers
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66—Non-ionic compounds
    • C11D1/72—Ethers of polyoxyalkylene glycols
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D2111/00—Cleaning compositions characterised by the objects to be cleaned; Cleaning compositions characterised by non-standard cleaning or washing processes
    • C11D2111/10—Objects to be cleaned
    • C11D2111/12—Soft surfaces, e.g. textile

Definitions

  • the present invention relates to a granular laundry detergent composition with an anti-microbial benefit.
  • an anti-microbial laundry detergent product is desired by users as it cleans fabrics whilst having an anti-microbial benefit on such fabrics.
  • various anti-microbial agents e.g., diphenyl ethers
  • diphenyl ether anti-microbial agents especially 4-4’-dichloro-2-hydroxy diphenyl ether (typically referred to as “Dichlosan” or by its tradename “ HP 100” as commercially available from BASF)
  • HP 100 4-4’-dichloro-2-hydroxy diphenyl ether
  • such anti-microbial agent needs to be provided in the granular laundry detergent products at a significantly higher concentration level than in the liquid laundry detergent products, to the point that it becomes too cost-prohibitive to use.
  • the present invention in one aspect relates to a granular laundry detergent composition
  • a granular laundry detergent composition comprising:
  • the granular laundry detergent composition is characterized by an Equilibrium pH ranging from about 6.5 to about 10.5.
  • the Equilibrium pH of the above-mentioned granular laundry detergent composition ranges from about 6.5 to about 10, preferably from about 7 to about 10, more preferably from about 7 to about 9.5, still more preferably from about 7 to about 9, most preferably from about 7 to about 8.5.
  • the anti-microbial agent may be present in an amount ranging from about 0.005%to about 2%, preferably from about 0.01%to about 1%, more preferably from about 0.02%to about 0.2%, by weight of the granular laundry detergent composition.
  • the granular laundry detergent composition may comprise a water-soluble alkali metal or alkaline earth metal sulfate, which may be selected from the group consisting of sodium sulfate, potassium sulfate, magnesium sulfate, and combinations thereof.
  • the water-soluble alkali metal or alkaline earth metal sulfate is sodium sulfate.
  • the water-soluble alkali metal or alkaline earth metal sulfate may be present in an amount ranging from about 20%to about 90%, preferably from about 30%to about 80%, more preferably from about 40%to about 70%, by weight of the granular laundry detergent composition.
  • the granular laundry detergent composition may comprise a water-soluble alkali metal carbonate, which may be selected from the group consisting of sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate, and combination thereof.
  • a water-soluble alkali metal carbonate is sodium carbonate.
  • the water-soluble alkali metal carbonate may be present in an amount ranging from about 0.01%to about 20%, preferably from about 0.1%to about 15%, more preferably from about 0.5%to about 10%, most preferably from about 1%to about 5%, by weight of the granular laundry detergent composition.
  • the granular laundry detergent composition may comprise a water-soluble acid, which is preferably a water-soluble C 1 -C 6 organic acid, e.g., citric acid, lactic acid, and combination thereof.
  • a water-soluble acid is citric acid.
  • the water-soluble organic acid may be present in an amount ranging from about 0.01%to about 20%, preferably about 0.1%to about 15%, more preferably from about 0.5%to about 10%, most preferably from about 0.75%to about 5%, by weight of the granular laundry detergent composition.
  • the surfactant in the granular laundry detergent composition comprises an anionic surfactant selected from the group consisting of C 6 -C 20 alkyl sulfates (AS) , C 6 -C 20 alkyl alkoxy sulfates (AAS) , C 6 -C 20 linear alkylbenzene sulfonates (LAS) , C 6 -C 20 methyl ester sulfonates (MES) , C 6 -C 20 alkyl ether carboxylates (AEC) , and combinations thereof.
  • AS alkyl sulfates
  • AAS alkyl alkoxy sulfates
  • LAS linear alkylbenzene sulfonates
  • MES C 6 -C 20 methyl ester sulfonates
  • AEC alkyl ether carboxylates
  • such anionic surfactant is present in an amount ranging from about 10%to about 60%, preferably from about 12%to about 50%, more preferably from about 15%to about 40%, by weight of the granular laundry detergent composition.
  • the granular laundry detergent composition may comprise a nonionic surfactant selected from the group consisting of C 6 -C 20 alkoxylated alcohols, while preferably such nonionic surfactant is present in an amount ranging from about 0.01%to about 10%, preferably from about 0.05%to about 5%, more preferably from about 0.1%to about 3%, by weight of the granular composition.
  • the granular laundry detergent composition may further comprise a cationic polymer a cationic polymer, which is preferably a cationic polysaccharide, more preferably a cationic cellulosic polymer, most preferably cationic hydroxyethylcellulose or cationic hydroxypropylcellulose or a combination thereof.
  • a cationic polymer may be present in an amount ranging from about 0.01%to about 5%, preferably from about 0.02%to about 1%, more preferably from about 0.05%to about 0.5%, by weight of the granular laundry detergent composition.
  • the present invention relates to a granular laundry detergent composition, comprising:
  • the granular laundry detergent compositions as described hereinabove are preferably characterized by a Bacteriostatic Activity Value of at least log 1 reduction, preferably at least log 2 reduction, more preferably at least log 2.5 reduction against both Gram-positive bacteria and Gram-negative bacteria.
  • the present invention relates to a method of improving the anti-microbial efficacy of 4-4’-dichloro-2-hydroxy diphenyl ether in a granular laundry detergent composition, by modulating the Equilibrium pH of such granular laundry detergent composition within a range from about 6.5 to about 10.5.
  • the above-mentioned Equilibrium pH modulating is conducted by using a pH buffer system comprising a water-soluble alkali metal carbonate and a water-soluble acid. More preferably, the water-soluble alkali metal carbonate is sodium carbonate, while the water-soluble acid is citric acid.
  • the sodium carbonate may be present in an amount ranging from 0.01%to about 20%, preferably from about 0.1%to about 15%, more preferably from about 0.5%to about 10%, most preferably from about 1%to about 5%, by weight of the granular laundry detergent composition.
  • the citric acid may be present in an amount ranging from 0.01%to about 20%, preferably from about 0.1%to about 15%, more preferably from about 0.5%to about 10%, most preferably from about 0.75%to about 5%, by weight of the granular laundry detergent composition.
  • the terms “comprise” , “comprises” , “comprising” , “include” , “includes” , “including” , “contain” , “contains” , and “containing” are meant to be non-limiting, i.e., other steps and other ingredients which do not affect the end of result can be added.
  • the above terms encompass the terms “consisting of” and “consisting essentially of” .
  • the term “granular laundry detergent composition” includes, unless otherwise indicated, all-purpose or “heavy-duty” laundry washing agents in solid, powdery form, as well as cleaning auxiliaries such as bleach, rinse aids, additives, or pre-treat types.
  • the granular laundry detergent composition is a free-flowing granular laundry detergent composition.
  • the term “laundry detergent composition” means a composition for cleaning soiled materials, including fabrics. Such compositions may be used as a pre-laundering treatment, a post-laundering treatment, or may be added during the rinse or wash cycle of the laundering operation.
  • fabric is used non-specifically and may refer to any type of natural or artificial fibers, including natural, artificial, and synthetic fibers, such as, but not limited to, cotton, linen, wool, polyester, nylon, silk, acrylic, and the like, as well as various blends and combinations.
  • composition is “substantially free of” or “substantially free from” a specific ingredient, it is meant that the composition comprises the indicated material in an amount ranging from 0%to about 0.5%, preferably from 0%to about 0.1%, by total weight of such composition.
  • anti-microbial agent refers to a chemical compound of which the principle intended function is to kill bacteria or to prevent their growth or reproduction.
  • main surfactant refers to a surfactant that is present in a composition at an amount that is greater than any other surfactant contained by such composition.
  • alkyl means a hydrocarbyl moiety which is branched or unbranched, substituted or unsubstituted. Included in the term “alkyl” is the alkyl portion of acyl groups.
  • water-soluble refers to a solubility of more than about 30 grams per liter (g/L) of deionized water measured at 20°C and under the atmospheric pressure.
  • Equilibrium pH refers to the pH value of a composition when measured at about 1.529 wt%dilution in water with a hardness level of about 342 mg/L at 20°C.
  • water can be formed, for example, by dissolving 0.034g CaCl 2 and 0.139g MgCl 2 ⁇ 6H 2 O in one (1) liter of deionized (DI) water.
  • DI deionized
  • washing solution refers to the typical amount of aqueous solution used for one cycle of laundry washing, preferably from 1 L to 50 L, alternatively from 1 L to 20 L for hand washing and from 20 L to 50 L for machine washing.
  • the anti-microbial granular laundry detergent composition of the present invention comprises, as one of its key ingredient, an anti-microbial agent of diphenyl ether type. More specifically, the diphenyl ether anti-microbial agent used in the present invention is a nonionic compound 4-4’-dichloro-2-hydroxy diphenyl ether (also referred to as “Diclosan” ) , which is commercially available from BASF under the trade name HP 100 and has the following chemical structure:
  • Such anti-microbial agent may provide anti-microbial benefits against both Gram-positive bacteria (e.g., Staphylococcus aureus) and Gram-negative bacteria (e.g., Klebsiella pneumoniae) , and is therefore particularly suitable for practice of the present invention.
  • Such anti-microbial agent is preferably present in the granular laundry detergent composition at an amount ranging from about 0.001%to about 3%, more preferably from about 0.005%to about 2%, still more preferably from about 0.01%to about 1%, most preferably from about 0.02%to 0.2%, by weight of the granular laundry detergent composition.
  • such a granular laundry detergent composition can preferably deliver the anti-microbial agent at a through-the-wash (TTW) concentration level ranging from about 0.01 ppm to about 5 ppm, more preferably from about 0.1 ppm to about 3 ppm, most preferably from about 0.25 ppm to about 1 ppm.
  • TSW through-the-wash
  • Detergent compositions preferably laundry detergent compositions, containing the above-mentioned anti-microbial agent may provide residual anti-microbial benefits to the fabrics treated by such compositions, i.e., the nonionic anti-microbial agent therein deposits onto the fabrics during a washing cycle and subsequently the deposited (i.e., residual) antimicrobial-agent prevents bacteria growth onto the fabrics during drying or storage or wear.
  • the nonionic anti-microbial agent therein deposits onto the fabrics during a washing cycle and subsequently the deposited (i.e., residual) antimicrobial-agent prevents bacteria growth onto the fabrics during drying or storage or wear.
  • residual antimicrobial-agent prevents bacteria growth onto the fabrics during drying or storage or wear.
  • 4-4’-dichloro-2-hydroxy diphenyl ether has not been successfully incorporated into granular laundry detergent products, due to the relatively poor anti-microbial efficacy it has exhibited in conventional granular laundry detergent products.
  • 4-4’-dichloro-2-hydroxy diphenyl ether needs to be deposited on to such treated fabrics after wash.
  • Such deposition process requires 4-4’-dichloro-2-hydroxy diphenyl ether to remain as insoluble solids in the washing solution; otherwise, it may be rinsed off together with the washing solution.
  • the Equilibrium pH of the granular laundry detergent composition of the present invention (as measured at 1.529 wt%dilution in water with a water hardness level of about 342 mg/L at 20°C, while the water can be formed by dissolving 0.034g CaCl 2 and 0.139g MgCl 2 ⁇ 6H 2 O in one liter of deionized water) to a relatively low range (i.e., lower in comparison with that of the conventional granular laundry detergent compositions) , which in turn results in a relatively lower Equilibrium pH of the washing solution, depronation and solubilization of 4-4’-dichloro-2-hydroxy diphenyl ether during wash may be reduced, and its deposition efficiency and corresponding anti-microbial efficacy may be effectively improved.
  • the Equilibrium pH of the granular laundry detergent composition of the present invention to a range of from about 6.5 to about 10.5, preferably from about 6.5 to about 10, more preferably from about 7 to about 10, still more preferably from about 7 to about 9.5, still more preferably from about 7 to about 9, most preferably from about 7 to about 8.5.
  • the present invention may employ a pH buffer system, which comprises for example a water-soluble alkali metal carbonate and/or a water-soluble acid, for pH modulation.
  • a pH buffer system which comprises for example a water-soluble alkali metal carbonate and/or a water-soluble acid, for pH modulation.
  • the water-soluble alkali metal carbonate is selected from the group consisting of sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate, and combination thereof. More preferably, the water-soluble alkali metal carbonate is sodium carbonate.
  • the water-soluble acid can be any suitable acid, either organic or inorganic.
  • the water-soluble acid is a water-soluble C 1 -C 6 organic acid, e.g., selected from the group consisting of citric acid, lactic acid, and combination thereof, while more preferably the water-soluble acid is citric acid.
  • Such water-soluble acid may be at least partially coated, or even completely coated, by a water-dispersible or water-soluble coating material.
  • a suitable water-dispersible coating material is wax, while a suitable water-soluble coating material is citrate.
  • the water-soluble alkali metal carbonate may be present in an amount ranging from 0%to about 20%, preferably from about 0.01%to about 20%, more preferably from about 0.1%to about 15%, still more preferably from about 0.5%to about 10%, most preferably from about 1% to about 5%, by weight of the granular laundry detergent composition.
  • the granular laundry detergent composition is substantially free of the water-soluble alkali metal carbonate, and more preferably it is substantially free of sodium carbonate.
  • the water-soluble acid can be present in an amount ranging from 0%to about 20%, preferably from about 0.01%to about 20%, more preferably from about 0.1%to about 15%, still more preferably from about 0.5%to about 10%, most preferably from about 0.75%to about 5%, by weight of the granular laundry detergent composition.
  • the composition provides at least a log 2.2 reduction in Bacteriostatic Activity Value, preferably a log 2.5 reduction in Bacteriostatic Activity Value, against Staphylococcus aureus and/or Klebsiella pneumoniae after a 10-minute contact time in a 1529 ppm aqueous solution as determined by the Anti-Microbial Test method described below.
  • the granular laundry detergent composition of the present invention is a fully formulated, solid, free-flowing particulate laundry detergent composition, not just a portion thereof (such as a spray-dried, extruded or agglomerate particle that only forms part of the laundry detergent composition) .
  • such granular laundry detergent composition comprises a plurality of chemically different particles, such as spray-dried base detergent particles and/or agglomerated base detergent particles and/or extruded base detergent particles, in combination with one or more, typically two or more, or five or more, or even ten or more particles selected from: surfactant particles, including surfactant agglomerates, surfactant extrudates, surfactant needles, surfactant noodles, surfactant flakes; phosphate particles; zeolite particles; polymer particles such as carboxylate polymer particles, cellulosic polymer particles, starch particles, polyester particles, polyamine particles, terephthalate polymer particles, polyethylene glycol particles; aesthetic particles such as coloured noodles, needles, lamellae particles and ring particles; enzyme particles such as protease granulates, amylase granulates, lipase granulates, cellulase granulates, mannanase granulates, pectate lya
  • the granular laundry detergent composition of the present invention comprises (in addition to the anti-microbial agent, the water-soluble alkali metal carbonate and the water-soluble organic acid as mentioned hereabove) : (a) from about 5%to about 70%, by weight of such composition, of a surfactant; (b) from about 20%to about 90%, by weight of such composition, of a water-soluble alkali metal or alkaline earth metal sulfate; (c) from 0%to about 8%, by weight of such composition, of zeolite builder; (d) from 0%to about 4%, by weight of such composition, of phosphate builder, while preferably such composition is substantially free of phosphate builder; and (e) from 0%to about 8%, by weight of such composition, of sodium silicate, while preferably such composition is substantially free of sodium silicate.
  • the water-soluble alkali metal or alkaline earth metal sulfate as mentioned hereinabove may be selected from the group consisting of sodium sulfate, potassium sulfate, magnesium sulfate, and combinations thereof.
  • the water-soluble alkali metal or alkaline earth metal sulfate is sodium sulfate and/or magnesium, and more preferably it is sodium sulfate.
  • Such water-soluble alkali metal or alkaline earth metal sulfate is preferably present in an amount ranging from about 30%to about 80%, more preferably from about 40%to about 70%, by weight of the granular laundry detergent composition.
  • the surfactant used in the granular laundry detergent composition of the present invention can be any suitable surfactant (s) , such as selected anionic surfactants, nonionic surfactants, amphoteric surfactants, and combinations thereof.
  • the surfactant of the present invention comprises an anionic surfactant selected from the group consisting of C 6 -C 20 alkyl sulfates (AS) , C 6 -C 20 alkyl alkoxy sulfates (AAS) , C 6 -C 20 linear alkylbenzene sulfonates (LAS) , C 6 -C 20 methyl ester sulfonates (MES) , C 6 -C 20 alkyl ether carboxylates (AEC) , and combinations thereof.
  • AS alkyl sulfates
  • AAS alkyl alkoxy sulfates
  • LAS linear alkylbenzene sulfonates
  • MES C 6 -C 20 methyl ester sulf
  • the granular laundry detergent composition of the present invention comprises two or more anionic surfactants, e.g., with one anionic surfactant functioning as the main surfactant and one or more anionic surfactants functioning as co-surfactants.
  • the granular laundry detergent composition comprises from about 10%to about 20%, by weight of such composition, of a C 6 -C 20 linear alkylbenzene sulfonates (LAS) , and more preferably from about 0.5%to about 2%, by weight of such composition, of a C 6 -C 20 alkyl ethoxy sulfate (AES) , e.g., a C 12 -C 14 AES having an average degree of ethoxylation of from about 0.5 to about 5, more preferably from about 1 to about 3.
  • the LAS surfactant may comprise at least 25wt%, of the combined total, of 2-phenyl isomer and 3-phenyl isomer. A suitable LAS surfactant having this feature is obtained by the DETAL synthesis.
  • the granular laundry detergent composition further comprises, in addition to the anionic surfactants mentioned hereinabove, a nonionic surfactant selected from the group consisting of: C 6 -C 20 alkyl ethoxylates, such as, non-ionic surfactants from Shell; C 6 -C 12 alkyl phenol alkoxylates wherein preferably the alkoxylate units are ethyleneoxy units, propyleneoxy units or a mixture thereof; C 12 -C 18 alcohol and C 6 -C 12 alkyl phenol condensates with ethylene oxide/propylene oxide block polymers such as from BASF; alkylpolysaccharides, preferably alkylpolyglycosides; methyl ester ethoxylates; polyhydroxy fatty acid amides; ether capped poly (oxyalkylated) alcohol surfactants; and mixtures thereof.
  • a nonionic surfactant selected from the group consisting of: C 6 -C 20 alkyl ethoxylates, such
  • Suitable non-ionic detersive surfactants also include alkyl alkoxylated alcohols, preferably C 6-20 alkyl alkoxylated alcohol, preferably a C 6-20 alkyl ethoxylated alcohol, preferably the alkyl alkoxylated alcohol has an average degree of alkoxylation of from 1 to 50, preferably from 1 to 30, or from 1 to 20, or from 1 to 10, preferably the alkyl alkoxylated alcohol is a C 6-20 alkyl ethoxylated alcohol having an average degree of ethoxylation of from 1 to 10, preferably from 1 to 7, more preferably from 1 to 5 and most preferably from 3 to 7.
  • the alkyl alkoxylated alcohol can be linear or branched, and substituted or un-substituted.
  • the nonionic surfactant is preferably selected from the group consisting of C 6 -C 20 alkoxylated alcohols, and it may be present in an amount ranging from about 0.01%to about 10%, preferably from about 0.05%to about 5%, more preferably from about 0.1%to about 3%, by weight of such composition.
  • the granular laundry detergent composition further comprises, in addition to the anionic surfactants, from about 0.1%to about 1%, by weight of such composition, of a C 6 - C 20 alkoxylated alcohol, which is preferably a C 12 -C 15 ethoxylated alcohol with from about 7 to about 9 EO units.
  • the granular laundry detergent composition of the present invention may further comprise one or more suitable cationic surfactants, such as alkyl pyridinium compounds, alkyl quaternary ammonium compounds, alkyl quaternary phosphonium compounds, alkyl ternary sulphonium compounds, and mixtures thereof.
  • suitable cationic surfactants such as alkyl pyridinium compounds, alkyl quaternary ammonium compounds, alkyl quaternary phosphonium compounds, alkyl ternary sulphonium compounds, and mixtures thereof.
  • the granular laundry detergent composition of the present invention may further comprise one or more zwitterionic surfactants, such as amine oxides and/or betaines.
  • zwitterionic surfactants such as amine oxides and/or betaines.
  • such composition further comprises an alkyl amine oxide.
  • the granular laundry detergent composition of the present invention may comprise from 0%to about 6%, preferably from 0%to about 4%, by weight of such composition, of sodium bicarbonate. Preferably, such composition is substantially free of sodium bicarbonate.
  • the granular laundry detergent composition of the present invention may further comprise, in addition to the ingredients disclosed hereinabove, one or more polymers selected from the group consisting of cationic polymers, carboxylate polymers, soil release polymers, anti-redeposition polymers, cellulosic polymers, care polymers and any combination thereof.
  • the granular laundry detergent composition of the present invention may comprise from 0.01%to 5%, preferably from 0.02%to 1%, more preferably from 0.05%to 0.5%, by weight of said composition, of a cationic polymer.
  • the cationic polymer preferably has a cationic charge density of from about 0.05 to about 23 milliequivalents/g, more preferably from about 0.01 to about 12 milliequivalents/g, most preferably from about 0.1 to about 7 milliequivalents/g.
  • the charge density is calculated by dividing the number of net charges per repeating unit by the molecular weight of the repeating unit.
  • the positive charges can be located on the backbone of the polymer and/or the side chains of the polymer.
  • Non-limiting examples of suitable cationic polymers are cationic polysaccharides, cationic proteins, and cationic synthetic polymers.
  • Cationic polysaccharides may include cationic cellulosic polymers, cationic guar gums, cationic chitosans, cationic starches, and derivatives and combinations thereof.
  • Suitable cationic polysaccharides include cationically modified celluloses, such as cationic hydroxyethylcellulose and/or cationic hydroxypropylcellulose.
  • Preferred cationic celluloses for use herein include those that may or may not be hydrophobically modified, including those having weight average molecular weights ranging from about 50,000 to about 2,000,000 Daltons, preferably from about 100,000 to about 1,000,000 Daltons, more preferably from about 200,000 to about 800,000 Daltons.
  • the granular laundry detergent composition may comprise from about 0.5%to about 5%, by weight of such composition, of a carboxylate co-polymer that comprises: (i) from about 50wt%to less than about 98 wt%of structural units derived from one or more monomers comprising carboxyl groups; (ii) from about 1 wt%to less than about 49 wt%of structural units derived from one or more monomers comprising sulfonate moieties; and (iii) from about 1 wt%to about 49 wt%of structural units derived from one or more types of monomers selected from ether bond-containing monomers.
  • a carboxylate co-polymer that comprises: (i) from about 50wt%to less than about 98 wt%of structural units derived from one or more monomers comprising carboxyl groups; (ii) from about 1 wt%to less than about 49 wt%of structural units derived from one or more monomers comprising sulfonate moie
  • the granular laundry detergent composition may further comprise a polyethylene glycol (PEG) polymer, which comprises a polyethylene glycol backbone with grafted polyvinyl acetate side chains.
  • PEG polyethylene glycol
  • the granular laundry detergent composition may further comprise a soil release polymer, such as a PEG-based polyester soil release polymer.
  • the granular laundry detergent composition may comprise the combination of a non-ionic soil release polymer and an anionic soil release polymer.
  • the granular laundry detergent composition may further comprise carboxymethyl cellulose having a degree of substitution greater than 0.65 and a degree of blockiness greater than 0.45.
  • the composition may comprise an alkoxylated polyalkyleneimine, while such alkoxylated polyalkyleneimine has a polyalkyleneimine core with one or more side chains bonded to at least one nitrogen atom in the polyalkyleneimine core.
  • such alkoxylated polyalkyleneimine may have an empirical formula (I) of (PEI) a - (EO) b -R 1 , wherein a is the average number-average molecular weight (MW PEI ) of the polyalkyleneimine core of the alkoxylated polyalkyleneimine and is in the range of from 100 to 100,000 Daltons, wherein b is the average degree of ethoxylation in said one or more side chains of the alkoxylated polyalkyleneimine and is in the range of from 5 to 40, and wherein R 1 is independently selected from the group consisting of hydrogen, C 1 -C 4 alkyls, and combinations thereof.
  • MW PEI average number-average molecular weight
  • the alkoxylated polyalkyleneimine may have an empirical formula (II) of (PEI) o - (EO) m (PO) n -R 2 or (PEI) o - (PO) n (EO) m -R 2 , wherein o is the average number-average molecular weight (MW PEI ) of the polyalkyleneimine core of the alkoxylated polyalkyleneimine and is in the range of from 100 to 100,000 Daltons, wherein m is the average degree of ethoxylation in said one or more side chains of the alkoxylated polyalkyleneimine which ranges from 10 to 50, wherein n is the average degree of propoxylation in said one or more side chains of the alkoxylated polyalkyleneimine which ranges from 1 to 50, and wherein R 2 is independently selected from the group consisting of hydrogen, C 1 -C 4 alkyls, and combinations thereof.
  • MW PEI average number-average molecular weight
  • Suitable care polymers include cellulosic polymers that are cationically modified or hydrophobically modified. Such modified cellulosic polymers can provide anti-abrasion benefits and dye lock benefits to fabric during the laundering cycle.
  • Suitable cellulosic polymers include cationically modified hydroxyethyl cellulose.
  • Other suitable care polymers include dye lock polymers, for example the condensation oligomer produced by the condensation of imidazole and epichlorhydrin, preferably in ratio of 1: 4: 1.
  • a suitable commercially available dye lock polymer is FDI (Cognis) .
  • Other suitable care polymers include amino-silicone, which can provide fabric feel benefits and fabric shape retention benefits.
  • the granular laundry detergent composition of the present invention may further comprise one or more of the following ingredients:
  • Suitable enzymes include lipases, proteases, cellulases, amylases and any combination thereof.
  • Suitable proteases include metalloproteases and/or serine proteases.
  • suitable neutral or alkaline proteases include: subtilisins (EC 3.4.21.62) ; trypsin-type or chymotrypsin-type proteases; and metalloproteases.
  • the suitable proteases include chemically or genetically modified mutants of the aforementioned proteases.
  • Suitable commercially available protease enzymes include those sold under the trade names Liquanase Savinase and by Novozymes A/S (Denmark) , those sold under the tradename Preferenz series of proteases including P280, P281, P2018-C, P2081-WE, P2082-EE and P2083-A/J, Purafect Purafect and Purafect by DuPont, those sold under the tradename and by Solvay Enzymes, those available from Henkel/Kemira; and KAP from Kao.
  • Suitable amylases are derived from AA560 alpha amylase endogenous to Bacillus sp. DSM 12649. Suitable commercially available amylases include Plus, Natalase, Ultra, SZ, (all Novozymes) and AA, Preferenz series of amylases, and Ox Am, HT Plus (all Du Pont) .
  • Suitable cellulases include those of bacterial or fungal origin. Chemically modified or protein engineered mutants are also suitable. Suitable cellulases include cellulases from the genera Bacillus, Pseudomonas, Humicola, Fusarium, Thielavia, Acremonium, e.g., the fungal cellulases produced from Humicola insolens, Myceliophthora thermophila and Fusarium oxysporum. Commercially available cellulases include and Premium, and (Novozymes A/S) , series of enzymes (Du Pont) , and series of enzymes (AB Enzymes) . Suitable commercially available cellulases include Premium, Classic.
  • Suitable lipases include those of bacterial, fungal or synthetic origin, and variants thereof. Chemically modified or protein engineered mutants are also suitable. Examples of suitable lipases include lipases from Humicola (synonym Thermomyces) , e.g., from H. lanuginosa (T. lanuginosus) . Preferred lipases include those sold under the tradenames and by Novozymes, Bagsvaerd, Denmark.
  • Suitable enzymes are bleaching enzymes, such as peroxidases/oxidases, which include those of plant, bacterial or fungal origin and variants thereof.
  • Commercially available peroxidases include (Novozymes A/S) .
  • Other suitable enzymes include choline oxidases and perhydrolases such as those used in Gentle Power Bleach TM .
  • Other suitable enzymes include pectate lyases sold under the tradenames (from Novozymes A/S, Bagsvaerd, Denmark) and (DuPont) and mannanases sold under the tradenames (Novozymes A/S, Bagsvaerd, Denmark) , and (Du Pont) .
  • Suitable bleach includes sources of hydrogen peroxide, bleach activators, bleach catalysts, pre-formed peracids and any combination thereof.
  • a particularly suitable bleach includes a combination of a source of hydrogen peroxide with a bleach activator and/or a bleach catalyst.
  • Suitable sources of hydrogen peroxide include sodium perborate and/or sodium percarbonate.
  • Suitable bleach activators include tetra acetyl ethylene diamine and/or alkyl oxybenzene sulphonate.
  • Suitable bleach catalysts include oxaziridinium bleach catalysts, transistion metal bleach catalysts, especially manganese and iron bleach catalysts.
  • Suitable pre-form peracids include phthalimido-peroxycaproic acid. However, it is preferred that the composition is substantially free of pre-formed peracid.
  • the granular laundry detergent composition may also comprise a chelant selected from: diethylene triamine pentaacetate, diethylene triamine penta (methyl phosphonic acid) , ethylene diamine-N’N’-disuccinic acid, ethylene diamine tetraacetate, ethylene diamine tetra (methylene phosphonic acid) and hydroxyethane di (methylene phosphonic acid) .
  • a preferred chelant is ethylene diamine-N’N’-disuccinic acid (EDDS) and/or hydroxyethane diphosphonic acid (HEDP) .
  • the composition preferably comprises ethylene diamine-N’N’-disuccinic acid or salt thereof.
  • the ethylene diamine-N’N’-disuccinic acid is in S, S enantiomeric form.
  • the composition comprises 4, 5-dihydroxy-m-benzenedisulfonic acid disodium salt.
  • Preferred chelants may also function as calcium carbonate crystal growth inhibitors such as: 1-hydroxyethanediphosphonic acid (HEDP) and salt thereof; N, N-dicarboxymethyl-2-aminopentane-1, 5-dioic acid and salt thereof; 2-phosphonobutane-1, 2, 4-tricarboxylic acid and salt thereof; and combination thereof.
  • HEDP 1-hydroxyethanediphosphonic acid
  • N N-dicarboxymethyl-2-aminopentane-1, 5-dioic acid and salt thereof
  • 2-phosphonobutane-1, 2, 4-tricarboxylic acid and salt thereof and combination thereof.
  • hueing agents are known and described in the art which may be suitable for the present invention.
  • Suitable hueing agents include small molecule dyes, typically falling into the Colour Index (C. I. ) classifications of Acid, Direct, Basic, Reactive (including hydrolysed forms thereof) or Solvent or Disperse dyes, for example classified as Blue, Violet, Red, Green or Black, and provide the desired shade either alone or in combination.
  • Preferred such hueing agents include Acid Violet 50, Direct Violet 9, 66 and 99, Solvent Violet 13 and any combination thereof.
  • Suitable hueing agents further include phthalocyanine and azo dye conjugates, alkoxylated bis-azo dyes, alkoxylated thiophene azo dyes, and the like.
  • the hueing agent may be incorporated into the detergent composition as part of a reaction mixture which is the result of the organic synthesis for a dye molecule, with optional purification step (s) .
  • Such reaction mixtures generally comprise the dye molecule itself and in addition may comprise un-reacted starting materials and/or by-products of the organic synthesis route.
  • Suitable hueing agents can further be incorporated into hueing dye particles.
  • Suitable dye transfer inhibitors include polyamine N-oxide polymers, copolymers of N-vinylpyrrolidone and N-vinylimidazole, polyvinylpyrrolidone, polyvinyloxazolidone, polyvinylimidazole and mixtures thereof.
  • Preferred are poly (vinyl pyrrolidone) , poly (vinylpyridine betaine) , poly (vinylpyridine N-oxide) , poly (vinyl pyrrolidone-vinyl imidazole) and mixtures thereof.
  • Suitable commercially available dye transfer inhibitors include PVP-K15 and K30 (Ashland) , HP165, HP50, HP53, HP59, HP56K, HP56, HP66 (BASF) , S-400, S403E and S-100 (Ashland) .
  • Suitable perfumes comprise perfume materials selected from the group: (a) perfume materials having a ClogP of less than 3.0 and a boiling point of less than 250°C (quadrant 1 perfume materials) ; (b) perfume materials having a ClogP of less than 3.0 and a boiling point of 250°C or greater (quadrant 2 perfume materials) ; (c) perfume materials having a ClogP of 3.0 or greater and a boiling point of less than 250°C (quadrant 3 perfume materials) ; (d) perfume materials having a ClogP of 3.0 or greater and a boiling point of 250°C or greater (quadrant 4 perfume materials) ; and (e) mixtures thereof. It may be preferred for the perfume to be in the form of a perfume delivery technology.
  • Such delivery technologies further stabilize and enhance the deposition and release of perfume materials from the laundered fabric.
  • perfume delivery technologies can also be used to further increase the longevity of perfume release from the laundered fabric.
  • Suitable perfume delivery technologies include: perfume microcapsules, pro-perfumes, polymer assisted deliveries, molecule assisted deliveries, fiber assisted deliveries, amine assisted deliveries, cyclodextrin, starch encapsulated accord, zeolite and other inorganic carriers, and any mixture thereof.
  • Suitable silicones include polydimethylsiloxane and amino-silicones.
  • the granular laundry detergent composition of the present invention can be prepared by any suitable method, including for example: spray-drying, agglomeration, extrusion and any combination thereof.
  • a suitable spray-drying process comprises the step of forming an aqueous slurry mixture, transferring it through at least one pump, preferably two pumps, to a pressure nozzle.
  • anionic surfactant such as linear alkyl benzene sulphonate
  • anionic surfactant such as linear alkyl benzene sulphonate
  • a gas such as air
  • any inorganic ingredients such as sodium sulphate and sodium carbonate, if present in the aqueous slurry mixture, to be micronized to a small particle size.
  • a suitable agglomeration process is used to form the granular laundry detergent composition of the present invention, which comprises the step of contacting a detersive ingredient, such as a detersive surfactant, e.g., linear alkyl benzene sulphonate (LAS) and/or alkyl alkoxylated sulphate, with an inorganic material, such as sodium carbonate and/or silica, in a mixer.
  • a detersive ingredient such as a detersive surfactant, e.g., linear alkyl benzene sulphonate (LAS) and/or alkyl alkoxylated sulphate
  • LAS linear alkyl benzene sulphonate
  • an inorganic material such as sodium carbonate and/or silica
  • the agglomeration process may also be an in-situ neutralization agglomeration process wherein an acid precursor of a detersive surfactant, such as LAS, is contacted with an alkaline material, such as carbonate and/or sodium hydroxide, in a mixer, and wherein the acid precursor of a detersive surfactant is neutralized by the alkaline material to form a detersive surfactant during the agglomeration process.
  • suitable detergent ingredients that may be agglomerated include polymers, chelants, bleach activators, silicones and any combination thereof.
  • the agglomeration process may be a high, medium or low shear agglomeration process, wherein a high shear, medium shear or low shear mixer is used accordingly.
  • the agglomeration process may be a multi-step agglomeration process wherein two or more mixers are used, such as a high shear mixer in combination with a medium or low shear mixer.
  • the agglomeration process can be a continuous process or a batch process. It may be preferred for the agglomerates to be subjected to a drying step, for example to a fluid bed drying step. It may also be preferred for the agglomerates to be subjected to a cooling step, for example a fluid bed cooling step.
  • the agglomerates are subjected to particle size classification, for example a fluid bed elutriation and/or a sieve, to obtain the desired particle size distribution.
  • the agglomerates have a particle size distribution such that weight average particle size is in the range of from 300 micrometers to 800 micrometers, and less than 10wt%of the agglomerates have a particle size less than 150 micrometers and less than 10wt%of the agglomerates have a particle size greater than 1200 micrometers.
  • ingredients such as polymer and/or non-ionic detersive surfactant and/or perfume to be sprayed onto base detergent particles, such as spray-dried base detergent particles and/or agglomerated base detergent particles.
  • base detergent particles such as spray-dried base detergent particles and/or agglomerated base detergent particles.
  • this spray-on step is carried out in a tumbling drum mixer.
  • the method of laundering fabric using the granular laundry detergent composition of the present invention comprises the step of contacting the solid composition to water to form a wash liquor, and laundering fabric in said wash liquor.
  • the wash liquor has a temperature of above 0°C to 90°C, or to 60°C, or to 40°C, or to 30°C, or to 20°C.
  • the fabric may be contacted to the water prior to, or after, or simultaneous with, contacting the solid composition with water.
  • the wash liquor is formed by contacting the laundry detergent to water in such an amount so that the concentration of laundry detergent composition in the wash liquor is from 0.2g/l to 20g/l, or from 0.5g/l to 10g/l, or to 5.0g/l.
  • the method of laundering fabric can be carried out in a front-loading automatic washing machine, top loading automatic washing machines, including high efficiency automatic washing machines, or suitable hand-wash vessels.
  • the wash liquor comprises 90 litres or less, or 60 litres or less, or 15 litres or less, or 10 litres or less of water.
  • 200g or less, or 150g or less, or 100g or less, or 50g or less of laundry detergent composition is contacted to water to form the wash liquor.
  • sample granular laundry detergent compositions The anti-microbial efficacy of sample granular laundry detergent compositions is measured as follows:
  • Each defined sample of a granular laundry detergent composition (e.g., 15.29g) to be tested is dissolved into 1 L of water with a water hardness level of 342 mg/L.
  • Such water is formed by dissolving 0.034g CaCl 2 and 0.139g MgCl 2 ⁇ 6H 2 O in 1L of deionized (DI) water.
  • DI deionized
  • the solution is mixed by a magnetic stirrer for about 4 minutes, followed by dispensing 265ml of such solution into the exposure chamber of a wash tumbler as described by the Degerming Test Method for Laundry Detergents as issued by the Japanese Detergent and Soap Fair Trade Council.
  • a stainless-steel spindle is fabricated from a single continuous piece of stainless steel wire having a diameter of about 1/16 inch by bending it to form 3 horizontal extensions, each about 2 inch in length, which are connected by 2 vertical sections of approximately 2 inch in length.
  • the spindle is used as a carrier for wrapping the fabric ballast.
  • cotton fabrics of approximately 300 grams are scoured by boiling for one hour in 3 L of distilled or DI water that contains about 1.5 grams of sodium carbonate and about 1.5 grams of a nonionic wetting agent.
  • the fabrics are then rinsed in boiling water and then in cold water, until all visual traces of foam formed by the wetting agent are removed.
  • the fabrics are then drained of water and air-dried for at least 24 hours at ambient temperature.
  • the scoured and dried fabrics are then cut into strips that has a width of about 2 inches and weighs about 15 ⁇ 0.1g each.
  • One piece of such cotton fabric strip is then taken, and one of its ends is secured onto the outer horizontal extension of the above-mentioned stainless-steel spindle.
  • This cotton fabric strip is wrapped around the three horizontal extensions of the spindle with sufficient tension for about 12 to 13 laps until the entire fabric strip has been wrapped onto the spindle.
  • a staple or pin may be used to secure the loose end of the fabric strip.
  • the fabric-wrapped spindles may then be sterilized, either in individual exposure chambers of the above-mentioned wash tumbler, or separately from the exposure chambers. The fabric wrapped on the spindle and the exposure chamber should both be dry prior to placement of the spindle into the exposure chamber.
  • the fabric-wrapped spindle is then placed into the exposure chamber of the wash tumbler that contains the 265ml washing solution as mentioned hereinabove.
  • the exposure chamber is then agitated for about 20 minutes at a speed of about 60 rpm.
  • the fabric-wrapped spindle is spun-dried for about 2 minutes, and the washing solution is discarded.
  • 265ml of fresh hard water as described hereinabove is dispensed into the same exposure chamber for rinsing the fabric-wrapped spindle.
  • the exposure chamber is agitated for another 3 minutes at the same agitation speed, and then the fabric-wrapped spindle is spun-dried again for about 2 minutes, followed by discarding the rinse solution.
  • the fabric-wrapped spindle is rinsed and spun-dried once more following the same procedure as described hereinabove.
  • the cotton fabric strip is taken off the spindle and air-dried overnight at ambient temperature.
  • the dried cotton fabric strip is then cut into 2cm ⁇ 2cm square pieces, and 10 pieces of such cotton fabrics are stacked together to form one test specimen, which weighs about 0.40 ⁇ 0.05g.
  • test specimen is then subjected to the Bacteriostatic Activity Evaluation method as described by Section 8.1 of the Japanese Industrial Standards (JIS) L1902-2015 standard, while the number of bacteria is calculated according to Section 8.1.4.5.2 (instead of calculating the amount of ATP as described in Section 8.1.4.5.3) .
  • JIS Japanese Industrial Standards
  • Example 1 Comparative Test Showing Effect of Equilibrium pH Value on Anti-Microbial Efficacy of Granular Laundry Detergent Compositions Containing 0.025%of 4-4’-Dichloro-2- Hydroxy Diphenyl Ether
  • the anti-microbial efficacy of each of the above-described granular laundry detergent compositions is measured at a dosage level of about 1529ppm in the washing solution formed by using water with a hardness level of about 342 mg/L (such hard water is formed by dissolving 0.034g CaCl 2 and 0.139g MgCl 2 ⁇ 6H 2 O in 1 liter of deionized water) , by using the Anti-Microbial Test described hereinabove. Following are the measurement results:
  • the Log Reduction of Bacteriostatic Activity Value is greater than 1 when the Equilibrium pH values of the above-described four granular laundry detergent compositions are about 9.5 or below.
  • Example 2 Comparative Test Showing Effect of Equilibrium pH Value on Anti-Microbial Efficacy of Granular Laundry Detergent Compositions Containing 0.05%of 4-4’-Dichloro-2- Hydroxy Diphenyl Ether
  • the anti-microbial efficacy of each of the above-described granular laundry detergent compositions is measured at a dosage level of about 1529ppm in the washing solution formed by using water with a hardness level of about 342 mg/L (such hard water is formed by dissolving 0.034g CaCl 2 and 0.139g MgCl 2 ⁇ 6H 2 O in 1 liter of deionized water) , by using the Anti-Microbial Test described hereinabove. Following are the measurement results:
  • the Log Reduction of Bacteriostatic Activity Value is greater than 1 when the Equilibrium pH values of the above-described five granular laundry detergent compositions are about 9.5 or below.
  • Example 3 Comparative Test Showing Effect of Equilibrium pH Value on Anti-Microbial Efficacy of Granular Laundry Detergent Compositions Containing 0.1%of 4-4’-Dichloro-2- Hydroxy Diphenyl Ether
  • the anti-microbial efficacy of each of the above-described granular laundry detergent compositions is measured at a dosage level of about 1529ppm in the washing solution formed by using water with a hardness level of about 342 mg/L (such hard water is formed by dissolving 0.034g CaCl 2 and 0.139g MgCl 2 ⁇ 6H 2 O in 1 liter of deionized water) , by using the Anti-Microbial Test described hereinabove. Following are the measurement results:
  • the Log Reduction of Bacteriostatic Activity Value is greater than 1 when the Equilibrium pH values of the above-described 4 granular laundry detergent compositions are about 10 or below.
  • Example 4 Exemplary Granular laundry detergent Compositions

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Abstract

Une composition de détergent textile granulaire contient l'agent antimicrobien 4-4'-dichloro-2-hydroxy diphényl éther, tandis qu'une telle composition de détergent textile granulaire est caractérisée par un pH d'équilibre relativement faible qui est particulièrement approprié pour améliorer l'efficacité antimicrobienne d'un tel agent antimicrobien.
PCT/CN2017/110782 2017-11-14 2017-11-14 Composition de détergent textile antimicrobienne granulaire WO2019095089A1 (fr)

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JP7485797B2 (ja) * 2020-07-03 2024-05-16 ザ プロクター アンド ギャンブル カンパニー 粒子状洗濯組成物
JP2023548699A (ja) * 2020-12-01 2023-11-20 ザ プロクター アンド ギャンブル カンパニー 衣類から微生物を洗浄後に除去する方法
CN113969219A (zh) * 2021-09-29 2022-01-25 洁悦科技(天津)有限公司 一种含有小麦蛋白酶的酵素洗衣液及制备方法
CN114085719A (zh) * 2021-11-29 2022-02-25 烟台三生生物科技有限公司 一种持久抑菌洗衣液及其制备方法

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