WO2019072005A1 - Impureté de disaccharide d'azacitidine, son procédé de préparation et son utilisation - Google Patents

Impureté de disaccharide d'azacitidine, son procédé de préparation et son utilisation Download PDF

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Publication number
WO2019072005A1
WO2019072005A1 PCT/CN2018/099074 CN2018099074W WO2019072005A1 WO 2019072005 A1 WO2019072005 A1 WO 2019072005A1 CN 2018099074 W CN2018099074 W CN 2018099074W WO 2019072005 A1 WO2019072005 A1 WO 2019072005A1
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WO
WIPO (PCT)
Prior art keywords
compound
formula
azacitidine
process according
reaction
Prior art date
Application number
PCT/CN2018/099074
Other languages
English (en)
Chinese (zh)
Inventor
邓海存
郭起
蒋兵
任晋生
张连第
Original Assignee
江苏先声药业有限公司
南京先声东元制药有限公司
芜湖先声中人药业有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 江苏先声药业有限公司, 南京先声东元制药有限公司, 芜湖先声中人药业有限公司 filed Critical 江苏先声药业有限公司
Publication of WO2019072005A1 publication Critical patent/WO2019072005A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/04—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D251/06—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

La présente invention concerne une impureté de disaccharide d'azacitidine, son procédé de préparation et son utilisation. Le composé de formule III, selon l'invention est obtenu par réaction d'un composé représenté par la formule IV en tant que matière première de départ avec un ribose tétraacétyl sous une catalyse d'un acide de Lewis, et le composé de formule III est hydrolysé pour obtenir un composé de formule II. Le composé de formule II préparé selon l'invention peut être utilisé en tant que référence pour la détection de matériaux apparentés à l'azacitidine, et est utilisé pour des applications de contrôle de qualité de l'azacitidine et des préparations associées de celle-ci.
PCT/CN2018/099074 2017-10-10 2018-08-07 Impureté de disaccharide d'azacitidine, son procédé de préparation et son utilisation WO2019072005A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201710933894.3 2017-10-10
CN201710933894.3A CN109651469B (zh) 2017-10-10 2017-10-10 阿扎胞苷二糖杂质与其制备方法与应用

Publications (1)

Publication Number Publication Date
WO2019072005A1 true WO2019072005A1 (fr) 2019-04-18

Family

ID=66101224

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2018/099074 WO2019072005A1 (fr) 2017-10-10 2018-08-07 Impureté de disaccharide d'azacitidine, son procédé de préparation et son utilisation

Country Status (2)

Country Link
CN (1) CN109651469B (fr)
WO (1) WO2019072005A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113201039B (zh) * 2021-05-19 2022-04-29 南京德克瑞医药化工有限公司 一种医药中间体2’,3’,5’-三乙酰阿扎胞苷的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006099132A1 (fr) * 2005-03-11 2006-09-21 Supergen, Inc. Analogues et derives d'azacytosine
CN104672289A (zh) * 2013-11-29 2015-06-03 南京圣和药业股份有限公司 一种阿扎胞苷杂质的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102702292B (zh) * 2012-05-20 2015-04-29 湖州展望药业有限公司 一种阿扎胞苷的制备方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006099132A1 (fr) * 2005-03-11 2006-09-21 Supergen, Inc. Analogues et derives d'azacytosine
CN104672289A (zh) * 2013-11-29 2015-06-03 南京圣和药业股份有限公司 一种阿扎胞苷杂质的制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NAEEM B. HANNA: "6-Methyl-5-Azacytidine-Synthesis, Conformational Pro- perties and Biological Activity. A Comparison of Molecular Conformation with 5-Azacytidine", NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS, vol. 16, 20 August 2006 (2006-08-20), ISSN: 0732-8311 *

Also Published As

Publication number Publication date
CN109651469A (zh) 2019-04-19
CN109651469B (zh) 2023-07-11

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