WO2019029114A1 - 一种养生补肾的人参含片及其制备方法 - Google Patents

一种养生补肾的人参含片及其制备方法 Download PDF

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WO2019029114A1
WO2019029114A1 PCT/CN2017/119858 CN2017119858W WO2019029114A1 WO 2019029114 A1 WO2019029114 A1 WO 2019029114A1 CN 2017119858 W CN2017119858 W CN 2017119858W WO 2019029114 A1 WO2019029114 A1 WO 2019029114A1
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extract
ginseng
weight
paste
reduced pressure
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French (fr)
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程炽坤
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程炽坤
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A61K36/066—Clavicipitaceae
    • A61K36/068—Cordyceps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A61K36/424—Gynostemma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969—Polygonatum (Solomon's seal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing

Definitions

  • the present invention relates to a ginseng lozenge, and more particularly to a ginseng lozenge for nourishing kidney.
  • ginseng As an ancient nutritional supplement, ginseng has the effects of refreshing, promoting blood circulation, anti-fatigue and improving immunity. Modern medical research shows that ginseng also has the effects of lowering blood pressure, inhibiting diabetes, improving memory, etc., and has the advantages of no drug resistance and wide application. Due to these unique effects of ginseng, it is widely used in the production of health foods such as ginseng granules, ginseng lozenges, and ginseng candy. However, the existing ginseng health foods generally have a single effect, and it is difficult to meet the needs of people for diversified health care, and the special odor of ginseng is also difficult for some consumers to accept.
  • the present invention aims to provide a ginseng lozenge which is used for nourishing and tonifying the kidney and a preparation method thereof, and the ginseng lozenge has the effects of tonifying qi, tonifying the kidney, enhancing immunity and the like.
  • a ginseng lozenge for tonifying kidney and tonifying comprising the following components: ginseng extract, maca extract, cordyceps extract, moringa seed extract, huangjing extract and chrysanthemum extract.
  • the ginseng lozenge containing the tonifying kidney and the kidney comprises the following components by weight:
  • the health-suppressing ginseng ginseng lozenge further comprises: an extract of Astragalus membranaceus and an extract of Gynostemma pentaphyllum.
  • the ginseng lozenge containing the tonifying kidney and the kidney comprises the following components by weight:
  • the ginseng lozenge containing the tonifying kidney and the kidney comprises the following components by weight:
  • the preparation method of the ginseng lozenge according to the present invention comprises the following steps: separately extracting ginseng extract, maca extract, cordyceps extract, Moringa seed extract, extract of Rhizoma Polygonati and chrysanthemum extract, and uniformly mixing Thereafter, the mixture is pulverized by a pulverizer, sieved, granulated, and dried, and then subjected to tablet molding.
  • the method for preparing a ginseng lozenge comprises the steps of: weighing ginseng extract, maca extract, cordyceps extract, Moringa seed extract, astragalus extract, and extract of Rhizoma Polygonum, respectively.
  • the Gynostemma pentaphyllum extract and the chrysanthemum extract are thoroughly mixed and pulverized by a pulverizer, sieved, granulated, and dried, and then subjected to tableting.
  • the ginseng extract is obtained by the following method: taking ginseng amount, pulverizing, adding 6 to 12 times by weight of 75 to 95% ethanol for extraction, and extracting the extract after concentration under reduced pressure to obtain ginseng paste After drying in a vacuum, the ginseng extract is obtained.
  • the maca extract is obtained by the following method: taking an appropriate amount of maca, after pulverizing, adding 6 to 12 times by weight of 75 to 95% ethanol for extraction, and extracting the extract after decompression to obtain a horse After the coffee paste is dried in a vacuum, the maca extract is obtained.
  • the Cordyceps militaris extract is obtained by the following method: taking an appropriate amount of Cordyceps militaris, and after pulverizing, adding 6 to 12 times by weight of 75 to 95% ethanol for extraction, and extracting the extract after decompression to obtain hydrazine.
  • the cordyceps paste is dried in a vacuum to obtain the extract of Cordyceps militaris.
  • the Moringa seed extract is obtained by the following method: taking an appropriate amount of Moringa seed, and after pulverizing, adding 6 to 12 times by weight of 75 to 95% ethanol for extraction, and extracting the extract after concentration under reduced pressure, The Moringa seed paste is obtained, and after drying in a vacuum, the Moringa seed extract is obtained.
  • the extract of Astragalus membranaceus is obtained by the following method: taking an appropriate amount of Astragalus, and after pulverizing, adding 6 to 12 times by weight of 75 to 95% ethanol for extraction, and extracting the extract after concentration under reduced pressure to obtain a scutellaria paste After drying in a vacuum, the extract of Astragalus membranaceus is obtained.
  • the extract of the yellow essence is obtained by the following method: taking an appropriate amount of the yellow essence seed, and after pulverizing, adding 6 to 12 times the weight of 75 to 95% ethanol for extraction, and extracting the extract after decompression to obtain a yellow essence cream. After the body is dried in a vacuum, the extract of the extract of the yellow essence is obtained.
  • the Gynostemma pentaphyllum extract is obtained by the following method: taking an appropriate amount of Gynostemma pentaphyllum, and after pulverizing, adding 6 to 12 times by weight of 75 to 95% ethanol for extraction, and extracting the extract solution under reduced pressure to obtain Gynostemma pentaphyllum paste After drying in vacuo, the Gynostemma pentaphyllum extract is obtained.
  • the chrysanthemum extract is obtained by the following method: taking an appropriate amount of chrysanthemum, and after pulverizing, adding 6 to 12 times by weight of distilled water for heating and leaching, and extracting the extract after decompression to obtain a chrysanthemum paste, and then After drying in vacuo, the chrysanthemum extract was obtained.
  • the ginseng lozenge sheet for nourishing and tonifying the kidney according to the present invention can enhance the efficacy of each component by the synergistic action between the components.
  • ginseng is known as the “King of Herbs” and is a good product of “Ziyin Replenishment, Fuzheng Guben”. It contains a variety of ginsenosides and polysaccharide active ingredients, which promote blood circulation, lower blood pressure and restore heart. Function, inhibition of diabetes, improvement of immunity, anti-fatigue, improvement of memory, improvement of neurasthenia and other effects.
  • Maca which is rich in protein, linolenic acid, linoleic acid, cellulose, vitamins and various minerals, and contains active ingredients of macaamide and macaene, which has a significant effect on balancing human hormone secretion.
  • Natural hormone engine it has the effects of improving endocrine, promoting metabolism, anti-oxidation, blood, kidney, calcium, immunity, and physical strength.
  • Cordyceps militaris also known as “Northern Cordyceps sinensis", contains active ingredients such as cordycepin, cordycepic acid, cordyceps polysaccharide, Cordyceps SOD and selenium (Se).
  • Cordycepin can inhibit the growth of cancer cells and have hypoglycemic effects; It can significantly reduce intracranial pressure and promote metabolism; Cordyceps polysaccharide can promote lymphocyte transformation, increase serum IgG antibody content and improve immunity; Cordyceps SOD can remove superoxide free radicals in the body, and has anti-cancer and anti-aging effects; Selenium can stimulate the production of immunoglobulins and antibodies, and enhance the body's immunity and antioxidant capacity.
  • Traditional Chinese medicine research has found that Cordyceps militaris has a good effect of nourishing the lungs and tonifying the kidneys, and has curative effects on kidney deficiency, waist and knee pain, post-disease weakness, night sweats, etc., and also improves liver detoxification ability.
  • Moringa seed which is a seed of Moringa tree, is rich in oleic acid, protein, polysaccharide and potassium, calcium, iron and other nutrients, can promote the body's metabolism, and has blood lipid lowering, lowering blood pressure, regulating the stomach and stomach, and enhancing human immunity. Improve sleep and other effects.
  • Astragalus membranaceus contains various active ingredients such as saponins, polysaccharides, amino acids, folic acid, and various trace elements such as selenium and zinc, which can enhance the body's immune function, and have the functions of protecting liver, diuresis, anti-aging, anti-stress and lowering blood pressure.
  • Astragalus can eliminate nephritis proteinuria, enhance myocardial contractility and regulate blood sugar levels.
  • Huang Jing is rich in steroidal saponins, polysaccharides such as Polygonatum, and has the effects of qi, spleen, lungs and kidney.
  • Gynostemma pentaphyllum contains Gynostemma saponins, Gynostemma, amino acids, flavonoids, various celluloses, minerals and other active ingredients, which have the effects of lowering blood fat, lowering blood pressure, regulating blood sugar, improving sleep, delaying aging, improving immunity, and regulating human physiological functions. It can protect the adrenal gland and thymus and maintain the function of the endocrine system.
  • Chrysanthemum contains inulin, chrysanthemum, borneol and multivitamins, which have the functions of clearing the liver and improving eyesight, sedation, antipyretic and enhancing capillary resistance.
  • the ginseng lozenge of the health-reinforcing and tonifying kidney according to the present invention is synergistically compounded with ginseng, maca, cordyceps, moringa, scutellaria, scutellaria, gynostemma and chrysanthemum, and has good immunity by utilizing the synergy between the components. Enhance, promote metabolism, nourish the kidney and nourish the lungs, thereby enhancing the qi, kidney, strengthening immunity, protecting the cardiovascular and cerebrovascular, nourishing the internal organs.
  • the chrysanthemum extract in the formula has a fragrant smell and can mask the bad odor of ingredients such as maca, cordyceps, moringa and gynostemma.
  • Example 1 Preparation of the ginseng lozenge of the health and kidney supplement of the present invention
  • ginseng extract Take 1kg of ginseng, after pulverization, add 10kg of 75% ethanol, after soaking, extract the pressure difference 3 times, combine the extracts, concentrate under reduced pressure, get ginseng paste, and then dry it by vacuum. Thereafter, the ginseng extract is obtained.
  • Preparation of maca extract Take 1kg of maca, after crushing, add 10kg of 95% ethanol, after soaking, extract the pressure difference 3 times, combine the extract, concentrate under reduced pressure, get maca paste, then After drying in vacuo, the maca extract was obtained.
  • Preparation of Cordyceps militaris extract Take 1kg of Cordyceps militaris, after pulverization, add 10kg of 75% ethanol, and after soaking, extract the pressure difference three times, combine the extracts, and concentrate under reduced pressure to obtain the locust grass paste. After drying in vacuo, the extract of Cordyceps militaris is obtained.
  • Preparation of Moringa seed extract Take 1kg of Moringa seed, after crushing, add 10kg of 95% ethanol, after soaking, extract the pressure difference 3 times, combine the extract, and concentrate under reduced pressure to obtain Moringa seed extract. The body is further dried in a vacuum to obtain the Moringa seed extract.
  • chrysanthemum extract 1 kg of chrysanthemum was taken, and after pulverization, 10 kg of distilled water was added thereto, and the mixture was heated and leached, and the extract was concentrated under reduced pressure to obtain a chrysanthemum paste, which was then dried under vacuum to obtain the chrysanthemum extract.
  • Ginseng extract 25g, maca extract 15g, Cordyceps extract 20g, Moringa seed extract 15g, Polygonatum extract 10g and chrysanthemum extract 20g were weighed separately, and then pulverized by a pulverizer. After sieving, granulation is carried out, and after drying, tableting is carried out to obtain the ginseng lozenge.
  • Example 2 Preparation of the ginseng lozenge of the health and kidney supplement of the present invention
  • ginseng extract Take 1kg of ginseng, after pulverization, add 10kg of 75% ethanol, after soaking, extract the pressure difference 3 times, combine the extracts, concentrate under reduced pressure, get ginseng paste, and then dry it by vacuum. Thereafter, the ginseng extract is obtained.
  • Preparation of maca extract Take 1kg of maca, after crushing, add 10kg of 95% ethanol, after soaking, extract the pressure difference 3 times, combine the extract, concentrate under reduced pressure, get maca paste, then After drying in vacuo, the maca extract was obtained.
  • Preparation of Cordyceps militaris extract Take 1kg of Cordyceps militaris, after pulverization, add 10kg of 75% ethanol, and after soaking, extract the pressure difference three times, combine the extracts, and concentrate under reduced pressure to obtain the locust grass paste. After drying in vacuo, the extract of Cordyceps militaris is obtained.
  • Preparation of Moringa seed extract Take 1kg of Moringa seed, after crushing, add 10kg of 95% ethanol, after soaking, extract the pressure difference 3 times, combine the extract, and concentrate under reduced pressure to obtain Moringa seed extract. The body is further dried in a vacuum to obtain the Moringa seed extract.
  • Astragalus membranaceus extract Take 1kg of Astragalus membranaceus, after pulverization, add 10kg of 75% ethanol, and after soaking, extract the pressure difference three times, combine the extracts, concentrate under reduced pressure, and obtain the scutellaria paste, then vacuum dry. Thereafter, the astragalus extract is obtained.
  • Gynostemma pentaphyllum extract Take 1kg of Gynostemma pentaphyllum, after pulverization, add 10kg of 95% ethanol, and after soaking, extract the pressure difference three times, combine the extracts, concentrate under reduced pressure, and obtain Gynostemma paste, then vacuum dry Thereafter, the Gynostemma pentaphyllum extract is obtained.
  • chrysanthemum extract 1 kg of chrysanthemum was taken, and after pulverization, 10 kg of distilled water was added thereto, and the mixture was heated and leached, and the extract was concentrated under reduced pressure to obtain a chrysanthemum paste, which was then dried under vacuum to obtain the chrysanthemum extract.
  • ginseng extract 25g maca extract 15g, Cordyceps extract 20g, Moringa seed extract 15g, Astragalus membranaceus extract 10g, Polygonatum extract 10g, Gynostemma pentaphyllum extract 10g and chrysanthemum extract 20g, fully mixed evenly Thereafter, the mixture was pulverized by a pulverizer, passed through a 100-mesh sieve, granulated, and dried, and then subjected to tablet molding to obtain the ginseng lozenge.
  • Embodiment 3 Effect test
  • Example 1 150 volunteers with low immunity and renal function problems were recruited and randomly divided into 3 groups.
  • the sample group was given the ginseng lozenges prepared in Example 1 and Example 2, and the control group was purchased on the market.
  • the ginseng contains tablets, and the blank group takes the vitamin tablets purchased on the market. Subjects took the test product twice a day for 60 consecutive days.
  • each subject was surveyed to score the product taste, body immunity improvement, renal function improvement and sleep quality improvement, and the highest score was divided into 10, and the higher the score, the higher the score. The higher the satisfaction.
  • the average scores of each group of subjects are shown in Table 1 below.
  • the test results show that taking the ginseng lozenge prepared by the invention can significantly improve the body immunity and kidney function of the consumer, and helps to improve the sleep quality of the consumer.

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Abstract

一种养生补肾的人参含片及其制备方法，该人参含片包括以下组分：人参提取物、玛咖提取物、蛹虫草提取物、辣木籽提取物、黄精提取物和菊花提取物。该人参含片还可进一步包含黄芪提取物和绞股蓝提取物。

Description

一种养生补肾的人参含片及其制备方法 技术领域
本发明涉及一种人参含片，更具体地，涉及一种养生补肾的人参含片。
背景技术
人参作为古老的营养滋补品，具有提神醒脑、促进血液循环、抗疲劳以及提高免疫力等功效。现代医学研究表明，人参还有降血压、抑制糖尿病、提高记忆力等功效，并具有无耐药性、适用人群广等优点。由于人参的这些独特功效，被广泛应用于制作人参冲剂、人参含片、人参糖果等保健食品。然而，现有的人参保健食品，普遍存在功效单一，难以满足人们对多元化保健的需要，且人参的特殊气味，亦使部分食用者难以接受。
发明内容
为了克服现有技术的不足，本发明的目的在于，提供一种养生补肾的人参含片及其制备方法，该人参含片具有补气、补肾、增强免疫力等功效。
本发明的目的通过下述技术方案实现：
一种养生补肾的人参含片，包括以下组分：人参提取物、玛咖提取物、蛹虫草提取物、辣木籽提取物、黄精提取物和菊花提取物。
进一步地，所述的养生补肾的人参含片，按重量份计算包括以下组分：
Figure PCTCN2017119858-appb-000001
进一步地，所述的养生补肾的人参含片，还包括：黄芪提取物和绞股蓝提取物。
进一步地，所述的养生补肾的人参含片，按重量份计算包括以下组分：
Figure PCTCN2017119858-appb-000002
进一步地，所述的养生补肾的人参含片，按重量份计算包括以下组分：
Figure PCTCN2017119858-appb-000003
Figure PCTCN2017119858-appb-000004
本发明所述的人参含片的制备方法，包括以下步骤：分别称取人参提取物、玛咖提取物、蛹虫草提取物、辣木籽提取物、黄精提取物和菊花提取物，充分混合均匀后，采用粉碎机进行粉碎，经过筛后，进行制粒，再经干燥后，进行压片成型。
进一步地，本发明所述的人参含片的制备方法，包括以下步骤：分别称取人参提取物、玛咖提取物、蛹虫草提取物、辣木籽提取物、黄芪提取物、黄精提取物、绞股蓝提取物和菊花提取物，充分混合均匀后，采用粉碎机进行粉碎，经过筛后，进行制粒，再经干燥后，进行压片成型。
进一步地，所述的人参提取物通过以下方法制得：取人参适量，经粉碎后，加入6～12倍重量的75～95％乙醇进行提取，提取液经减压浓缩后，得到人参膏体，再经真空干燥后，得到所述的人参提取物。
进一步地，所述的玛咖提取物通过以下方法制得：取玛咖适量，经粉碎后，加入6～12倍重量的75～95％乙醇进行提取，提取液经减压浓缩后，得到玛咖膏体，再经真空干燥后，得到所述的玛咖提取物。
进一步地，所述的蛹虫草提取物通过以下方法制得：取蛹虫草适量，经粉碎后，加入6～12倍重量的75～95％乙醇进行提取，提取液经减压浓缩后，得到蛹虫草膏体，再经真空干燥后，得到所述的蛹虫草提取物。
进一步地，所述的辣木籽提取物通过以下方法制得：取辣木籽适量，经粉碎后，加入6～12倍重量的75～95％乙醇进行提取，提取液经减压浓缩后，得到辣木籽膏体，再经真空干燥后，得到所述的辣木籽提取物。
进一步地，所述的黄芪提取物通过以下方法制得：取黄芪适量，经粉碎后，加入6～12倍重量的75～95％乙醇进行提取，提取液经减压浓缩后，得到黄芪膏体，再经真空干燥后，得到所述的黄芪提取物。
进一步地，所述的黄精提取物通过以下方法制得：取黄精籽适量，经粉碎后，加入6～12倍重量的75～95％乙醇进行提取，提取液经减压浓缩后，得到黄精膏体，再经真空干燥后，得到所述的黄精提取物。
进一步地，所述的绞股蓝提取物通过以下方法制得：取绞股蓝适量，经粉碎后，加入6～12倍重量的75～95％乙醇进行提取，提取液经减压浓缩后，得到绞股蓝膏体，再经真空干燥后，得到所述的绞股蓝提取物。
进一步地，所述的菊花提取物通过以下方法制得：取菊花适量，经粉碎后，加入6～12倍重量的蒸馏水进行加热浸提，提取液经减压浓缩后，得到菊花膏体，再经真空干燥后，得 到所述的菊花提取物。
本发明所述的养生补肾的人参含片，通过各成分之间的协同作用，能够提升各成分的功效作用。本配方中，人参被誉为“百草之王”，为“滋阴补生，扶正固本”佳品，其含有多种人参皂苷和多糖类活性成分，具有促进血液循环、降血压、恢复心脏功能、抑制糖尿病、提高免疫力、抗疲劳、提高记忆力、改善神经衰弱等功效。玛咖，其富含蛋白质、亚麻酸、亚油酸、纤维素、维生素及多种矿物质等营养成分，并含有玛咖酰胺、玛咖烯植物活性成分，对平衡人体荷尔蒙分泌有显著作用，被誉为“天然荷尔蒙发动机”，具有改善内分泌、促进新陈代谢、抗氧化、补血、补肾、补钙、提高免疫力、恢复体力等功效。蛹虫草，又称为“北冬虫夏草”，其含有虫草素、虫草酸、虫草多糖、虫草SOD和硒(Se)等活性成分，虫草素能够抑制癌细胞的生长，并有降血糖作用；虫草酸能够显著降低颅内压，促进新陈代谢；虫草多糖能够促进淋巴细胞转化，提高血清IgG抗体含量，提高机体免疫力；虫草SOD能够清除机体内的超氧自由基，具有抗癌、抗衰老的作用；硒元素则能刺激免疫球蛋白和抗体的产生，增强机体免疫和抗氧化能力。中医研究发现，蛹虫草具有良好的养肺、补肾作用，对肾虚、腰膝酸痛、病后虚弱、盗汗等均有疗效，同时还能够提高肝脏解毒能力。辣木籽，为辣木树的种子，其富含油酸、蛋白质、多糖和钾、钙、铁等营养成分，能够促进机体新陈代谢，并具有降血脂、降血压、调节肠胃、增强人体免疫力、改善睡眠等功效。黄芪含有多种皂苷、多糖、氨基酸、叶酸等活性成分，以及硒、锌等多种微量元素，能够增强机体免疫功能，并具有保肝、利尿、抗衰老、抗应激和降血压等作用，实验证明，黄芪能消除肾炎蛋白尿，增强心肌收缩力和调节血糖含量。黄精富含甾体皂苷、黄精多糖等成分，具有补气、健脾、润肺、益肾等功效。绞股蓝含有绞股蓝皂苷、绞股蓝糖苷、氨基酸、黄酮、多种纤维素、矿物质等活性成分，具有降血脂、降血压、调节血糖、改善睡眠、延缓衰老、提高免疫力、调节人体生理机能等作用，并能保护肾上腺和胸腺，维持内分泌系统的机能。菊花含有菊苷、菊花酮、龙脑及多种维生素，具有清肝明目、镇静、解热、增强毛细血管抵抗力等作用。
本发明所述的养生补肾的人参含片，采用人参、玛咖、蛹虫草、辣木籽、黄芪、黄精、绞股蓝和菊花进行协同复配，利用各成分之间的协同作用，具有良好的免疫提升、促进新陈代谢、补肾养肺作用，从而起到补气、补肾、增强免疫力、保护心脑血管、滋养五脏六腑的功效。配方中的菊花提取物，具有清香气味，能够掩盖玛咖、蛹虫草、辣木籽和绞股蓝等成分的不良气味。
具体实施方式
下面结合实施例及附图对本发明作进一步详细的描述，但本发明的实施方式不限于此。
实施例一：制备本发明所述的养生补肾的人参含片
人参提取物的制备：取人参1kg，经粉碎后，加入75％乙醇10kg，经浸泡后，进行压差提取3次，合并提取液，经减压浓缩后，得到人参膏体，再经真空干燥后，得到所述的人参提取物。
玛咖提取物的制备：取玛咖1kg，经粉碎后，加入95％乙醇10kg，经浸泡后，进行压差提取3次，合并提取液，经减压浓缩后，得到玛咖膏体，再经真空干燥后，得到所述的玛咖提取物。
蛹虫草提取物的制备：取蛹虫草1kg，经粉碎后，加入75％乙醇10kg，经浸泡后，进行压差提取3次，合并提取液，经减压浓缩后，得到蛹虫草膏体，再经真空干燥后，得到所述的蛹虫草提取物。
辣木籽提取物的制备：取辣木籽1kg，经粉碎后，加入95％乙醇10kg，经浸泡后，进行压差提取3次，合并提取液，经减压浓缩后，得到辣木籽膏体，再经真空干燥后，得到所述的辣木籽提取物。
黄精提取物的制备：取黄精1kg，经粉碎后，加入75％乙醇10kg，经浸泡后，进行压差提取3次，合并提取液，经减压浓缩后，得到黄精膏体，再经真空干燥后，得到所述的黄精提取物。
菊花提取物的制备：取菊花1kg，经粉碎后，加入蒸馏水10kg，进行加热浸提，提取液经减压浓缩后，得到菊花膏体，再经真空干燥后，得到所述的菊花提取物。
分别称取人参提取物25g、玛咖提取物15g、蛹虫草提取物20g、辣木籽提取物15g、黄精提取物10g和菊花提取物20g，充分混合均匀后，用粉碎机进行粉碎，经过100目筛后，进行制粒，再经干燥后，进行压片成型，得到所述的人参含片。
实施例二：制备本发明所述的养生补肾的人参含片
人参提取物的制备：取人参1kg，经粉碎后，加入75％乙醇10kg，经浸泡后，进行压差提取3次，合并提取液，经减压浓缩后，得到人参膏体，再经真空干燥后，得到所述的人参提取物。
玛咖提取物的制备：取玛咖1kg，经粉碎后，加入95％乙醇10kg，经浸泡后，进行压差提取3次，合并提取液，经减压浓缩后，得到玛咖膏体，再经真空干燥后，得到所述的玛咖提取物。
蛹虫草提取物的制备：取蛹虫草1kg，经粉碎后，加入75％乙醇10kg，经浸泡后，进行压差提取3次，合并提取液，经减压浓缩后，得到蛹虫草膏体，再经真空干燥后，得到所述的蛹虫草提取物。
辣木籽提取物的制备：取辣木籽1kg，经粉碎后，加入95％乙醇10kg，经浸泡后，进行压差提取3次，合并提取液，经减压浓缩后，得到辣木籽膏体，再经真空干燥后，得到所述的辣木籽提取物。
黄芪提取物的制备：取黄芪1kg，经粉碎后，加入75％乙醇10kg，经浸泡后，进行压差提取3次，合并提取液，经减压浓缩后，得到黄芪膏体，再经真空干燥后，得到所述的黄芪提取物。
黄精提取物的制备：取黄精1kg，经粉碎后，加入75％乙醇10kg，经浸泡后，进行压差提取3次，合并提取液，经减压浓缩后，得到黄精膏体，再经真空干燥后，得到所述的黄精提取物。
绞股蓝提取物的制备：取绞股蓝1kg，经粉碎后，加入95％乙醇10kg，经浸泡后，进行压差提取3次，合并提取液，经减压浓缩后，得到绞股蓝膏体，再经真空干燥后，得到所述的绞股蓝提取物。
菊花提取物的制备：取菊花1kg，经粉碎后，加入蒸馏水10kg，进行加热浸提，提取液经减压浓缩后，得到菊花膏体，再经真空干燥后，得到所述的菊花提取物。
分别称取人参提取物25g、玛咖提取物15g、蛹虫草提取物20g、辣木籽提取物15g、黄芪提取物10g、黄精提取物10g、绞股蓝提取物10g和菊花提取物20g，充分混合均匀后，用粉碎机进行粉碎，经过100目筛后，进行制粒，再经干燥后，进行压片成型，得到所述的人参含片。
实施例三：效果测试
招募150名患有免疫力低下并伴有肾功能问题的志愿者，随机分为3组，其中，样品组分别服用实施例一、实施例二制得的人参含片，对照组服用市场上购买的人参含片，空白组服用市场上购买的维生素含片。受试者每天服用试验产品两次，连续服用60天。
试验60天后，对每位受试者作问卷调查，分别就产品口感、机体免疫力改善度、肾功能改善度以及睡眠质量改善度进行评分，以10分为最高分，分值越高则代表满意度越高。每组受试者的评分平均值如下表1所示。
表1 人参含片功能效果测试结果
Figure PCTCN2017119858-appb-000005
Figure PCTCN2017119858-appb-000006
试验结果表明，服用本发明制得的人参含片，能显著改善食用者的机体免疫力以及肾功能，并有助于改善食用者的睡眠质量。
上述实施例为本发明较佳的实施方式，但本发明的实施方式并不受上述实施例的限制，其他的任何未背离本发明的精神实质与原理下所作的改变、修饰、替代、组合、简化，均应为等效的置换方式，都包含在本发明的保护范围之内。

Claims (10)

  1. 一种养生补肾的人参含片，其特征在于，包括以下组分：人参提取物、玛咖提取物、蛹虫草提取物、辣木籽提取物、黄精提取物和菊花提取物。
  2. 根据权利要求1所述的人参含片，其特征在于，按重量份计算包括以下组分：
    Figure PCTCN2017119858-appb-100001
  3. 根据权利要求2所述的人参含片，其特征在于，按重量份计算包括以下组分：
    Figure PCTCN2017119858-appb-100002
  4. 根据权利要求3所述的人参含片，其特征在于，按重量份计算包括以下组分：
    Figure PCTCN2017119858-appb-100003
  5. 权利要求1或2所述的人参含片的制备方法，其特征在于，包括以下步骤：分别称取人参提取物、玛咖提取物、蛹虫草提取物、辣木籽提取物、黄精提取物和菊花提取物，充分混合均匀后，采用粉碎机进行粉碎，经过筛后，进行制粒，再经干燥后，进行压片成型。
  6. 根据权利要求5所述的制备方法，其特征在于，所述的人参提取物通过以下方法制得：取人参适量，经粉碎后，加入6～12倍重量的75～95％乙醇进行提取，提取液经减压浓缩后，得到人参膏体，再经真空干燥后，得到所述的人参提取物；所述的玛咖提取物通过以下方法制得：取玛咖适量，经粉碎后，加入6～12倍重量的75～95％乙醇进行提取，提取液经减压浓缩后，得到玛咖膏体，再经真空干燥后，得到所述的玛咖提取物。
  7. 根据权利要求5所述的制备方法，其特征在于，所述的蛹虫草提取物通过以下方法制得：取蛹虫草适量，经粉碎后，加入6～12倍重量的75～95％乙醇进行提取，提取液经减压浓缩后，得到蛹虫草膏体，再经真空干燥后，得到所述的蛹虫草提取物；所述的辣木籽提取物通过以下方法制得：取辣木籽适量，经粉碎后，加入6～12倍重量的75～95％乙醇进行提取，提取液经减压浓缩后，得到辣木籽膏体，再经真空干燥后，得到所述的辣木籽提取物。
  8. 根据权利要求5所述的制备方法，其特征在于，所述的黄精提取物通过以下方法制得：取黄精籽适量，经粉碎后，加入6～12倍重量的75～95％乙醇进行提取，提取液经减压浓缩后，得到黄精膏体，再经真空干燥后，得到所述的黄精提取物；所述的菊花提取物通过以下方法制得：取菊花适量，经粉碎后，加入6～12倍重量的蒸馏水进行加热浸提，提取液经减压浓缩后，得到菊花膏体，再经真空干燥后，得到所述的菊花提取物。
  9. 权利要求3或4所述的人参含片的制备方法，其特征在于，包括以下步骤：分别称取人参提取物、玛咖提取物、蛹虫草提取物、辣木籽提取物、黄芪提取物、黄精提取物、绞股蓝提取物和菊花提取物，充分混合均匀后，采用粉碎机进行粉碎，经过筛后，进行制粒，再经干燥后，进行压片成型。
  10. 根据权利要求9所述的制备方法，其特征在于，所述的黄芪提取物通过以下方法制得：取黄芪适量，经粉碎后，加入6～12倍重量的75～95％乙醇进行提取，提取液经减压浓缩后，得到黄芪膏体，再经真空干燥后，得到所述的黄芪提取物；所述的绞股蓝提取物通过以下方法制得：取绞股蓝适量，经粉碎后，加入6～12倍重量的75～95％乙醇进行提取，提取液经减压浓缩后，得到绞股蓝膏体，再经真空干燥后，得到所述的绞股蓝提取物。
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