WO2019024933A1 - Cellule car nk ciblant gpc3 - Google Patents
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- A61K39/4613—Natural-killer cells [NK or NK-T]
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- C12N5/06—Animal cells or tissues; Human cells or tissues
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Abstract
L'invention concerne une cellule NK à récepteur d'antigène chimérique exprimant une reconnaissance spécifique pour GPC3 et sa méthode de préparation, ainsi qu'une utilisation de la cellule dans la prévention et/ou le traitement de cancers, en particulier un cancer exprimant GPC3. L'invention concerne également une utilisation de la cellule NK en tant qu'agent thérapeutique cellulaire de ciblage et/ou en immunothérapie adoptive de cancers.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710661765.3 | 2017-08-04 | ||
| CN201710661765 | 2017-08-04 |
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| WO2019024933A1 true WO2019024933A1 (fr) | 2019-02-07 |
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| PCT/CN2018/098623 WO2019024933A1 (fr) | 2017-08-04 | 2018-08-03 | Cellule car nk ciblant gpc3 |
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| Country | Link |
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| CN (1) | CN109385403B (fr) |
| WO (1) | WO2019024933A1 (fr) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3747433A4 (fr) * | 2018-02-02 | 2021-12-22 | Cafa Therapeutics Limited | Association d'immunothérapie cellulaire |
| WO2022028623A1 (fr) | 2020-08-07 | 2022-02-10 | 佧珐药业有限公司 | Cellules modifiées et procédé de modification de cellules |
| WO2022214089A1 (fr) | 2021-04-08 | 2022-10-13 | 克莱格医学有限公司 | Utilisation d'immunothérapie cellulaire |
| WO2023274303A1 (fr) | 2021-06-29 | 2023-01-05 | 科济生物医药（上海）有限公司 | Polypeptide chimérique pour la régulation de l'activité physiologique cellulaire |
| WO2023178333A1 (fr) * | 2022-03-18 | 2023-09-21 | WUGEN, Inc. | Constructions de récepteurs chimériques améliorées pour cellules nk |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112175085B (zh) * | 2019-06-14 | 2022-11-04 | 厦门大学 | 抗gpc3抗体及其用途 |
| CN110627909B (zh) * | 2019-08-28 | 2021-03-30 | 中国人民解放军第二军医大学 | 一种特异性活化nk细胞的嵌合抗原受体及其应用 |
| CN110684117B (zh) * | 2019-09-25 | 2021-01-01 | 汕头普罗凯融生物医药科技有限公司 | 一种car嵌合抗原受体序列及应用其的car-nk细胞 |
| CN112608905A (zh) * | 2021-01-18 | 2021-04-06 | 梅奥(浙江)细胞工程有限责任公司 | 靶向gpc3的car-nk细胞及其制备方法和应用 |
| WO2022198611A1 (fr) * | 2021-03-25 | 2022-09-29 | 汕头普罗凯融生物医药科技有限公司 | Séquence de récepteur antigénique chimérique car et cellules car-nk l'utilisant |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104140974A (zh) * | 2013-05-08 | 2014-11-12 | 上海益杰生物技术有限公司 | 编码gpc-3嵌合抗原受体蛋白的核酸及表达gpc-3嵌合抗原受体蛋白的t淋巴细胞 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015142661A1 (fr) * | 2014-03-15 | 2015-09-24 | Novartis Ag | Récepteur d'antigène chimèrique régulable |
| EP3141603A4 (fr) * | 2014-05-08 | 2017-12-27 | Chugai Seiyaku Kabushiki Kaisha | Agent thérapeutique ciblant le gpc3 pour administration à des patients pour qui la thérapie par agent thérapeutique ciblant le gpc3 est efficace |
| US11376326B2 (en) * | 2015-07-01 | 2022-07-05 | Chugai Seiyaku Kabushiki Kaisha | GPC3-targeting therapeutic agent which is administered to patient for whom the GPC3-targeting therapeutic agent is effective |
| DK3333192T3 (da) * | 2015-08-03 | 2021-05-31 | Cafa Therapeutics Ltd | Antistof imod glypican-3 og anvendelse deraf |
| US20180371052A1 (en) * | 2015-12-22 | 2018-12-27 | Icell Gene Therapeutics Llc | Chimeric antigen receptors and enhancement of anti-tumor activity |
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2018
- 2018-08-03 CN CN201810879882.1A patent/CN109385403B/zh active Active
- 2018-08-03 WO PCT/CN2018/098623 patent/WO2019024933A1/fr active Application Filing
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104140974A (zh) * | 2013-05-08 | 2014-11-12 | 上海益杰生物技术有限公司 | 编码gpc-3嵌合抗原受体蛋白的核酸及表达gpc-3嵌合抗原受体蛋白的t淋巴细胞 |
Non-Patent Citations (2)
| Title |
|---|
| LI, KEYU ET AL.: "Chimeric Antigen Receptor-Engineered T Cells for Liver Cancers, Progress and Obstacles", TUMOR BIOLOGY, vol. 39, no. 3, 28 March 2017 (2017-03-28), pages 1 - 8, XP055571345, ISSN: 1423-0380 * |
| YU , MIN ET AL.: "Development of GPC3-Specific Chimeric Antigen Receptor-Engineered Natural Killer Cells for the Treatment of Hepatocellular Carcinoma", MOLECULAR THERAPY, vol. 26, no. 2, 7 February 2018 (2018-02-07), pages 366 - 378, XP055565104, ISSN: 1525-0016 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3747433A4 (fr) * | 2018-02-02 | 2021-12-22 | Cafa Therapeutics Limited | Association d'immunothérapie cellulaire |
| WO2022028623A1 (fr) | 2020-08-07 | 2022-02-10 | 佧珐药业有限公司 | Cellules modifiées et procédé de modification de cellules |
| WO2022214089A1 (fr) | 2021-04-08 | 2022-10-13 | 克莱格医学有限公司 | Utilisation d'immunothérapie cellulaire |
| WO2023274303A1 (fr) | 2021-06-29 | 2023-01-05 | 科济生物医药（上海）有限公司 | Polypeptide chimérique pour la régulation de l'activité physiologique cellulaire |
| WO2023178333A1 (fr) * | 2022-03-18 | 2023-09-21 | WUGEN, Inc. | Constructions de récepteurs chimériques améliorées pour cellules nk |
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| Publication number | Publication date |
|---|---|
| CN109385403A (zh) | 2019-02-26 |
| CN109385403B (zh) | 2024-03-08 |
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