WO2019021988A1 - 外用組成物 - Google Patents
外用組成物 Download PDFInfo
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- WO2019021988A1 WO2019021988A1 PCT/JP2018/027449 JP2018027449W WO2019021988A1 WO 2019021988 A1 WO2019021988 A1 WO 2019021988A1 JP 2018027449 W JP2018027449 W JP 2018027449W WO 2019021988 A1 WO2019021988 A1 WO 2019021988A1
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- uridine
- acceptable salt
- physiologically acceptable
- composition
- composition according
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
Definitions
- the present application relates to a topical composition for moisturizing, anti-wrinkling, anti-sagging, wound healing, preventing hair loss, hair growth, prevention / treatment of atopic dermatitis, cell growth promotion, and hyaluronic acid production promotion. Furthermore, the present application relates to a method of enhancing skin moisture, a method of suppressing wrinkles, a method of suppressing slack, a method of treating wounds, a method of preventing hair loss, a method of promoting hair growth, and a method of preventing / treating atopic dermatitis , A method of promoting the growth of cells, and a method of promoting the production of hyaluronic acid.
- the skin originally has a moisturizing function
- the sebaceous membrane on the surface of the skin prevents the evaporation of water from the body, and natural moisturizing factors such as amino acids and mineral salts in the skin retain the water inside the skin .
- natural moisturizing factors such as amino acids and mineral salts in the skin retain the water inside the skin .
- the amount of sebum and natural moisturizing factors decreases and the moisturizing function of the skin declines.
- Hyaluronic acid which is one of the natural moisturizing factors, is a linear high-molecular polysaccharide made of ⁇ -D-N-acetylglucosamine and ⁇ -D-glucuronic acid alternately linked, and has high water retention ability .
- the skin has a layered structure of the epidermis, the dermis, and the subcutaneous tissue in order from the outside.
- Hyaluronic acid is mainly formed by keratinocytes present in the epidermis and fibroblasts present in the dermis, filling the extracellular space of the epidermis and the network structure of the dermis, deeply maintaining the function of the cells and maintaining the homeostasis of the skin. Involved.
- the skin is particularly abundant in the dermis, and the amount of hyaluronic acid in the skin is reduced by physiological aging.
- Hyaluronic acid is used as a typical moisturizing ingredient in many cosmetics and the like.
- hyaluronic acid has been reported to have many functions such as promoting tissue regeneration although the whole body has not yet been clarified, and many more uses, for example, wrinkles It is used in the treatment of sagging (S. A.) and in the treatment of wounds (S. A.) and in the treatment of atopic dermatitis (S. A.).
- the molecular weight of hyaluronic acid generally formulated in cosmetics etc. is 1,000,000 or more, and it is known that it is applied to the skin even if it is applied to the skin. Delivery is difficult. That is, although the external preparation containing hyaluronic acid can moisturize the skin surface, it can not enhance the water retention ability inside the skin. Therefore, for example, although a hyaluronic acid-containing external preparation is useful for epidermal wrinkles, an effect can not be expected for dermal wrinkles, and for dermal wrinkles, an invasive method such as direct injection of hyaluronic acid into the skin is used. It is performed (nonpatent literature 1).
- Patent Documents 1 and 2 disclose that acetylglucosamine, glucuronic acid, and the like are substances that promote hyaluronic acid production. .
- these documents only disclose the effect on the stratum corneum which is the outermost layer of the epidermis, and the effect on the dermis in which a large amount of hyaluronic acid is present has not been confirmed.
- the dermal papilla cells are said to be the commanding tower for hair growth signals, and are central to hair care research. Many studies focusing on hair papilla cells have been accumulated so far in hair growth and hair loss, and it is known that hair papilla cell growth promotion brings about a hair growth effect. Although these agents based on the dermal papilla cell growth promoting action have been developed (for example, Patent Documents 6 and 7), there is still a need for new hair growth promoting agents and hair loss preventing agents.
- Uridine monophosphate is one of the nucleotides and is a phosphate ester of uridine.
- Patent Document 2 Patent Document 3 and Patent Document 4 disclose that uridine monophosphate is used as an enhancer for other active ingredients, but in any of these documents, uridine monophosphate alone is used. There is no disclosure of functioning as an active ingredient.
- Patent Document 5 discloses that when keratocytes are treated with uridine, production of hyaluronic acid is promoted.
- the patent document relates to a composition for the prevention / treatment of dry eye syndrome, and is not intended to promote hyaluronic acid production in the skin.
- the subject of the present application is an external composition useful for moisturizing, anti-wrinkling, anti-sagging, wound treatment, preventing hair loss, hair growth, or prevention / treatment of atopic dermatitis, which promotes the production of hyaluronic acid in skin epidermis and skin dermis. It is to provide a thing. Furthermore, the subject of the present application is a method of enhancing moisturizing of the skin, a method of suppressing wrinkles, a method of suppressing slack, a method of treating wounds, a method of preventing hair loss, a method of promoting hair growth, and prevention / atopic dermatitis It is to provide a method of treatment.
- uridine phosphate alone has an excellent cell growth promoting action, and hyaluronic acid in skin epidermis and skin dermis. It has been found that production can be promoted, and the present invention has been made.
- the present invention provides the following: [1] Uridine phosphate or its physiologically acceptable salt, active ingredient for moisturizing, anti-wrinkling, anti-sagging, wound healing, prevention of hair loss, hair growth, or prevention / treatment of atopic dermatitis
- a composition for external use characterized in that it contains [2] The composition according to [1], comprising the phosphoric acid ester of uridine or a physiologically acceptable salt thereof as the sole active ingredient. [3] to [1] or [2] without an effective amount of moisturizing, anti-wrinkling, anti-sagging, wound healing, prevention of hair loss, hair growth, or other active ingredients for prevention / treatment of atopic dermatitis Composition as described.
- the uridine phosphate ester or a physiologically acceptable salt thereof is selected from uridine monophosphate, uridine diphosphate, uridine triphosphate, or a physiologically acceptable salt thereof.
- [5] Any one of [1] to [4], wherein the phosphate ester of uridine or a physiologically acceptable salt thereof is selected from uridine monophosphate or a physiologically acceptable salt thereof The composition as described in.
- [6] Any one of [1] to [5], wherein the phosphate ester of uridine or a physiologically acceptable salt thereof is selected from uridine 5'-phosphate or a physiologically acceptable salt thereof The composition according to item 1.
- composition according to any one of [1] to [6], which is an external composition for use in skin [8] The composition according to any one of [1] to [7], wherein the composition is used for the purpose of promoting cell growth or for the purpose of promoting hyaluronan production. [9] The composition according to any one of [1] to [8], which is a cosmetic, an external preparation, or a quasi-drug for external use.
- a composition for external use comprising a phosphate of uridine or a physiologically acceptable salt thereof as an active ingredient for promoting cell growth or hyaluronic acid production.
- the composition according to [10] which comprises the uridine phosphate ester or a physiologically acceptable salt thereof as the sole active ingredient.
- the composition according to [10] or [11] which does not contain an effective amount of other active ingredients for promoting cell growth or hyaluronic acid production.
- the uridine phosphate ester or a physiologically acceptable salt thereof is selected from uridine monophosphate, uridine diphosphate, uridine triphosphate, or a physiologically acceptable salt thereof, The composition according to any one of [10] to [12].
- composition according to any one of [10] to [16] used for applications selected from moisturizing, anti-wrinkling, anti-sagging, wound healing, prevention of hair loss, hair growth, or prevention / treatment of atopic dermatitis
- the composition according to [17] which does not contain an effective amount of other active ingredients for moisturizing, anti-wrinkle, anti-sagging, wound healing, prevention of hair loss, hair growth, or prevention / treatment of atopic dermatitis .
- a method comprising applying uridine phosphate or a physiologically acceptable salt thereof to the skin, said method comprising the steps of (1) to (9): (1) Enhances moisturizing of skin (2) Suppresses wrinkles (3) Suppresses sagging (4) Treats wounds (5) Prevents hair loss (6) Promotes hair growth (7) Atopic dermatitis (8) promoting the proliferation of cells (9) a method used for the purpose selected from promoting hyaluronic acid production.
- a phosphate of uridine or a physiologically acceptable salt thereof in the preparation of an external composition containing the physiologically acceptable salt thereof Or the use of a phosphate of uridine or a physiologically acceptable salt thereof in the preparation of an external composition containing the physiologically acceptable salt thereof.
- a phosphate or ester of uridine for use in moisturizing, anti-wrinkling, anti-sagging, wound healing, preventing hair loss, hair growth, prevention / treatment of atopic dermatitis, cell growth promotion, or hyaluronic acid production promotion Its physiologically acceptable salt.
- compositions of the present application can promote cell growth.
- the composition of the present application can promote the production of hyaluronic acid in skin epidermal cells and skin dermal cells, impart moisture retention and flexibility to the skin, and can maintain a firm and firm skin.
- the composition of the present application can prevent hair loss or promote hair growth.
- FIG. 7 is a view showing the amount of hyaluronic acid produced when human epidermal keratinocytes were cultured in media containing UMP2Na or uridine at various concentrations in Test Example 1.
- FIG. 7 is a diagram showing the amount of hyaluronic acid produced when human dermal fibroblasts were cultured in media containing various concentrations of UMP2Na or uridine in Test Example 1.
- Experiment 2 it is a figure which shows a cell count at the time of culture
- Experiment 3 it is a figure which shows the cell count at the time of culturing human hair papilla cells in the culture medium containing UMP2Na of various density
- Experiment 4 it is a figure which shows the produced
- composition of the present invention is used as an active ingredient for moisturizing, anti-wrinkle, anti-sagging, wound healing, preventing hair loss, hair growth, prevention / treatment of atopic dermatitis, cell growth promotion, or hyaluronic acid production promotion. It is characterized in that it contains a phosphoric acid ester or a physiologically acceptable salt thereof.
- the active ingredient is a substance that can independently exhibit the intended physiological action on the skin, and it is expected that the composition containing the active ingredient exhibits the intended physiological action.
- physiological actions for the purpose include moisturizing action, anti-wrinkle action, anti-sag action, wound healing action, hair loss preventing action, hair growth promoting action, atopic dermatitis prevention / treatment action, cells (eg hyaluronic acid-producing cells) (For example, keratinocytes, fibroblasts, dermal papilla cells) Growth promoting action or hyaluronic acid production promoting action can be mentioned.
- the active ingredient alone can exhibit a desired physiological action
- the desired physiological action may be additively or synergistically enhanced by being used in combination with other ingredients.
- the sole active ingredient means that the phosphate ester of uridine or a physiologically acceptable salt thereof does not depend on the interaction with other active ingredients, and the moisturizing action, anti-wrinkle action, anti-sag action, wound treatment Action, hair loss prevention action, hair growth promotion action, atopic dermatitis prevention / treatment action, cell (for example, hyaluronic acid-producing cells (eg, keratinocytes, fibroblasts), dermal papilla cells) growth promotion action, or hyaluronic acid production promotion It is meant to be capable of exerting an action, and does not exclude that the composition of the present invention contains other active ingredients.
- the term "effective amount” refers to moisturizing, anti-wrinkle, anti-sagging, wound healing, prevention of hair loss, hair growth, prevention / treatment of atopic dermatitis, cell growth promotion, or hyaluronic acid production promotion. Means an effective amount.
- moistureturizing, anti-wrinkle, anti-sagging, wound treatment, prevention of hair loss, hair growth, or other active ingredients for the prevention / treatment of atopic dermatitis means moisturizing, anti-wrinkle, anti-sagging, wound
- uridine means an ingredient other than uridine phosphate or a physiologically acceptable salt thereof which is known as an active ingredient for treatment, prevention of hair loss, hair growth, or prevention / treatment of atopic dermatitis.
- uridine monophosphate uridine 5'-phosphate, uridine 3'-phosphate, uridine 2'-phosphate
- uridine diphosphate uridine triphosphate
- uridine triphosphate examples of phosphate esters of uridine.
- uridine cyclic phosphate examples of preferred uridine phosphate esters include uridine monophosphate, more preferably uridine 5'-phosphate.
- physiologically acceptable salts of uridine phosphate include alkali metal salts such as sodium salt and potassium salt; alkaline earth metal salts such as calcium salt, magnesium salt and barium salt; bases such as arginine and lysine Amino acid salts; ammonium salts such as ammonium salts and tricyclohexylammonium salts; monoethanolamine salts, diethanolamine salts, triethanolamine salts, monoisopropanolamine salts, diisopropanolamine salts and various alkanolamine salts such as triisopropanolamine It can be mentioned.
- Preferred salts are alkali metal salts such as sodium salts. Examples of such alkali metal salts include uridine monophosphate monosodium and uridine monophosphate disodium (hereinafter UMP2Na).
- the phosphate ester of uridine or a physiologically acceptable salt thereof is a single phosphate ester of uridine or a salt thereof, a mixture of multiple types of phosphate esters of uridine or a salt thereof It may be
- the amount of phosphate ester of uridine or a physiologically acceptable salt thereof to be incorporated into the composition of the present invention includes the type of phosphate ester of uridine or a physiologically acceptable salt thereof, and the composition Although it varies depending on the use, the form and the like, it can be appropriately selected, for example, from the range of usually 0.0001 to 20% by weight, preferably 0.0001 to 10% by weight, with respect to the total weight of the composition.
- it is 0.001 wt% to 10 wt%, more preferably 0.01 wt% to 10 wt%, more preferably 0.01 wt% to 5 wt%, still more preferably 0.1 wt% to 10 wt% %, Particularly preferably 0.5% to 5% by weight, preferably 0.05% to 3% by weight, and more preferably 0.1% to 1% by weight.
- the upper limit of the content of uridine phosphate or the physiologically acceptable salt thereof contained in the composition of the present application preferably 10% by weight, 7% by weight relative to the total weight of the composition %, 5% by weight, 3% by weight, and 2% by weight, and particularly preferably 1% by weight.
- the lower limit of the content of uridine phosphate or the physiologically acceptable salt thereof contained in the composition of the present application preferably 0.01% by weight based on the total weight of the composition, 0.05% by weight, 0.1% by weight, 0.5% by weight and 0.7% by weight and particularly preferably 1% by weight.
- composition of the present invention can be prepared in various forms in combination with a pharmaceutically or cosmetically acceptable base or carrier, in addition to the uridine phosphate or its physiologically acceptable salt.
- a pharmaceutically or cosmetically acceptable base and carrier those known in the art can be used.
- the composition of the present invention may be blended with known various components to be incorporated in the composition for external use applied to the skin and mucous membranes such as cosmetics and external medicines / quasi-drugs if necessary. it can.
- surfactants for example, surfactants, dyes (dyes, pigments), fragrances, preservatives, bactericides (antimicrobial agents), thickeners, antioxidants, sequestering agents, refreshing agents, deodorants, Moisturizers, UV absorbers, UV scatterers, vitamins, plant extracts, skin astringents, anti-inflammatory agents (anti-inflammatory agents), whitening agents, cell activators, vasodilators, blood circulation enhancers, skin function enhancers, etc. Can be mentioned.
- surfactants include higher fatty acid soaps, alkyl sulfates, polyoxyethylene alkyl ether sulfates, alkyl ether phosphates, N-acyl amino acid salts, acyl N-methyl taurine salts
- Anionic surfactants such as: alkyltrimethylammonium chloride, cationic surfactants such as dialkyldimethylammonium chloride; alkyldimethylaminoacetic acid betaines, alkylamidodimethylaminoacetic acid betaines, 2-alkyl-N-carboxy-N-hydroxyimidazolinium Amphoteric surfactants such as betaine; and nonionic surfactants such as polyoxyethylene type, polyhydric alcohol ester type, ethylene oxide / propylene oxide block copolymer and the like can be mentioned. Also, without being particularly limited, surfactants belonging to high molecular weight surfactants and natural surfactants can also be used.
- preservatives ethyl parahydroxybenzoate, salicylic acid, sorbic acid and the like can be exemplified.
- thickener xanthan gum, sodium carboxymethylcellulose, carboxyvinyl polymer and the like can be exemplified.
- sequestering agent sodium salt of ethylenediaminetetraacetic acid, phosphoric acid, citric acid and the like can be exemplified.
- the composition of the present invention can be used as an external composition applied or sprayed on the skin.
- the composition of the present invention can be used as an external preparation (skin care agent) such as a cosmetic, an external preparation, or an external preparation.
- cosmetics are preferred from the viewpoint that they can usually promote the production of hyaluronic acid in the skin.
- Such external preparations include various hair cosmetics such as hair-growing agents and hair-growing agents, or shampoos, rinses, and hair lotions (including tonics and liquids) that are effective for hair growth and hair growth.
- the composition of the present invention is preferably formulated into the hair cosmetics exemplified above.
- the composition of the present invention can also be used as an agent for promoting hair loss / anti-hair loss such as eyebrows, eyelashes, etc. which the user desires to increase / elongate.
- Hair growth means healthy growth of existing hair including hair growth, and also includes promotion of generation of new hair.
- the prevention of hair loss means preventing the existing hair from falling off.
- composition of the present invention When the composition of the present invention is used for the prevention of hair growth or hair loss, the composition of the present invention has uses associated with these uses (eg, prevention or treatment of thin hair, hair growth promotion, hair growth) It can be used for promotion, treatment of hair loss after illness and postpartum, hair growth etc.).
- composition of the present invention is not particularly limited as long as it is applicable to the skin and mucous membranes, and, for example, paste, mousse, gel, liquid, emulsion, suspension, cream, ointment And solid, sheet, aerosol, spray and liniment agents can be exemplified.
- paste, mousse, gel liquid, emulsion, suspension, cream, ointment And solid, sheet, aerosol, spray and liniment agents
- emulsions such as emollient emulsions, milky lotions, nourishing emulsions, cleansing emulsions, etc.
- emollient creams massage creams, cleansing creams, makeup creams, etc. creams; lip creams etc.
- soap emulsions
- emollient creams emollient creams
- massage creams cleansing creams, makeup creams, etc. creams
- a hair product such as a hair-growing agent or a hair-growing agent
- tonics hair creams, hair lotions, aerosols (sprays), mousses, shampoos, rinses, liquids and the like
- hair creams hair lotions
- aerosols sprays
- mousses hair creams
- shampoos rinses
- liquids liquids and the like
- composition of the present invention can be used by directly applying, spraying or sticking on the skin as a cosmetic, an external preparation or an external preparation.
- the rate of use depends on the age of the user (human), sex, use, the degree of symptoms of the affected area, etc., and the effective dose to achieve the desired effect is once per day or five or six times per day. Administered transdermally to the skin.
- the duration of use of the composition of the present invention is not limited, but is preferably used continuously to effectively sustain cell growth promotion and / or hyaluronic acid production promotion, for example, one month (preferably) It can be used for 2 months or more).
- the composition of the present invention can be used for anti-aging, moisturizing, anti-wrinkle, anti-sagging, hair growth, hair loss prevention, wound healing, atopy by promoting cell growth and / or promoting the production of hyaluronic acid. It is possible to exert preventive / therapeutic effects such as prevention / treatment of xeroderma dermatitis, xerostomia and the like. Therefore, the composition of the present invention is intended for the prevention / treatment of anti-aging, moisturizing, anti-wrinkle, anti-sagging, hair growth, prevention of hair loss, wound treatment, atopic dermatitis prevention / treatment, senile xerosis etc. It can be used as a cosmetic, an external medicine or an external medicine.
- acetyl glucosamine, glucuronic acid, glucuronic acid salts, or derivatives thereof are proposed to be formulated in cosmetics in combination with a phosphate of uridine in JP-A-2014-88329. And the like.
- a derivative of acetylglucosamine has the following chemical formula (1): (R 1 is a hydrogen atom or an alkyl group having 2 to 18 carbon atoms. R 2, R 3 and R 4 are a hydrogen atom or an acyl group having 2 to 18 carbon atoms.
- the steric structure at position 1 may be either ⁇ or ⁇ , provided that all of R 1, R 2, R 3 and R 4 should not be hydrogen atoms.
- Glucuronic acid salts are potassium salts, sodium salts, and other physiologically acceptable salts.
- Derivatives of glucuronic acid are glucuronolactone and glucuronoxylan.
- a purine nucleic acid-related substance proposed to be incorporated in cosmetics etc. in combination with a phosphate ester of uridine in International Publication Nos. WO 2003/084485 and WO 2005/034902
- the composition which does not contain is mentioned.
- the purine nucleic acid-related substance includes adenine, adenosine, phosphate ester of adenosine [adenosine 2'-phosphate, adenosine 3'-phosphate, adenosine 5'-phosphate, adenosine 5'-diphosphate Adenosine 5'-triphosphate, adenosine cyclic phosphate, adenylosuccinate, nicotinamide adenine monodinucleotide (NMN), nicotinamide adenine dinucleotide (NAD), nicotinamide adenine dinucleotide phosphate (NADP), flavin adenine di Nucleotides (FAD)], their metabolites [hypoxanthine, inosine, inosinic acid] and salts thereof; guanine, guanosine, phosphate of guanosine [gua
- the above salts are alkali metal salts such as sodium salts and potassium salts; alkaline earth metal salts such as calcium salts, magnesium salts and barium salts; basic amino acid salts such as arginine and lysine; ammonium salts and tricyclohexyl ammonium salts Monoethanolamine salts, diethanolamine salts, triethanolamine salts, monoisopropanolamine salts, diisopropanolamine salts and alkanolamine salts such as triisopropanolamine.
- the present invention provides a method for enhancing skin moisturization, a method for suppressing wrinkles, a method for suppressing sagging, a method for treating wounds, a method for preventing hair loss, a method for promoting hair growth, and a method for preventing / treating atopic dermatitis
- Methods methods of promoting proliferation of cells (eg, hyaluronic acid-producing cells (eg, keratinocytes, fibroblasts), dermal papilla cells), and methods of promoting the production of hyaluronic acid are provided.
- the method is carried out by applying uridine phosphate ester or a physiologically acceptable salt thereof to the skin.
- the application of the substance to the skin can be conveniently performed by applying, spraying or sticking the composition according to the present invention on the skin.
- the frequency and amount of application of uridine phosphate or its physiologically acceptable salt to the skin are not particularly limited. For example, depending on the subject's age, sex, expected effects, degree of skin symptoms, etc., the appropriate amount is applied to the skin percutaneously in a number of times from once a day to 5 or 6 times a day .
- the application ratio of the composition to the area of skin to be applied is 0.5 to 10 mg / cm 2
- An amount that falls within the range of 1 can be used as a measure of the amount applied once.
- the use period of the method of the present invention is not limited, but is preferably used continuously to effectively sustain cell growth promotion and hyaluronic acid production promotion, for example, one month (preferably two months) Or more) can be used.
- w / v% means weight (g) contained in 100 mL.
- Example 1 Lotion Water (pH 6.5) UMP2Na 3.0 (% by weight) Polyoxyethylene (E.O. 60) hydrogenated castor oil 0.7 Ethanol 5.0 Glycerin 2.0 Preservative Suitable amount Perfume Suitable amount pH adjuster Appropriate amount Purified water residue 100.0% by weight in total According to a conventional method, a lotion of the above formulation is prepared.
- Example 2 Latex (pH 6.5) UMP2Na 1.5 (weight%) Carboxy vinyl polymer 0.3 Decaglycerin monomyristate 2.0 Squalane 5.0 Ethanol 1.0 Glycerin 6.0 Preservative Appropriate amount pH Adjuster Appropriate amount Purified water Residual Total 100.0% by weight
- Example 3 Hair restorer (pH 7.0) UMP2Na 3 (% by weight) Polyoxyethylene polyoxypropylene decyl tetradecyl ether 0.5 Ethanol 30 1,3-butylene glycol 2.5 Preservative Suitable amount Perfume Suitable amount pH adjuster Appropriate amount Purified water Remaining total 100.0% by weight According to a conventional method, the hair growth preparation of the above formulation is prepared.
- Example 1 Evaluation of hyaluronic acid production promoting effect of UMP 2 Na and uridine in cultured human epidermal keratinocytes and dermal fibroblasts>
- the precultured primary cultured human epidermal keratinocytes (manufactured by Kurabo) are cultured in a growth factor-containing EpiLife liquid medium (ThermoFisher Scientific) in a 96-well microplate, and then each concentration (0%) in a growth factor-free medium. , 10 -6 , 10 -5 , 10 -4 , 10 -3 , 10 -2 mol / L), and the solution was exchanged with UMP 2 Na or uridine solution.
- the precultured primary cultured dermal fibroblasts (manufactured by Kurabo) are cultured in serum-containing Medium 106 liquid medium (manufactured by ThermoFisher Scientific) in a 96-well microplate, and then each concentration (0, 10 -6 ) in serum-free medium , 10 -5 , 10 -4 , 10 -3 and 10 -2 mol / L), and the solution was exchanged with UMP 2 Na or uridine solution. These were cultured at 37 ° C., 5% CO 2 for 48 and 72 hours.
- FIG. 1 shows the results of epidermal keratinocytes.
- FIG. 2 shows the results of dermal fibroblasts.
- Example 2 Evaluation of the growth promoting effect of UMP 2 Na and uridine in cultured human skin fibroblasts>
- the precultured primary cultured human dermal fibroblasts (manufactured by Kurabo) are cultured in serum-containing Medium 106 liquid medium (manufactured by ThermoFisher Scientific) in a 96-well microplate, and after adhesion is stabilized, each concentration (0%) , 10 -6 , 10 -5 , 10 -4 , 10 -3 , 10 -2 mol / L), and the solution was exchanged with UMP 2 Na or uridine solution.
- the number of cells in each well was detected using a WST-1 reagent (manufactured by Takara Bio Inc.), and then measured with a microplate reader. The results are shown in FIG.
- Example 3 Evaluation of the growth promoting effect of UMP2Na on cultured human dermal papilla cells> Drug-containing test prepared by culturing precultured primary cultured human dermal papilla cells (Takara Bio Inc.) in a dermal papilla cell growth medium (Takara Bio Inc.) in a 96-well microplate and stabilizing the adhesion to various concentrations The medium was replaced. This was cultured at 37 ° C., 5% CO 2 for 72, 96 and 120 hours. After culture for each time, cell nuclei were stained and the number of cells in each well was counted. The results are shown in FIG.
- ⁇ Test Example 4 Evaluation of the hyaluronic acid production promoting effect of adenosine monophosphate disodium in cultured human dermal fibroblasts>
- the precultured primary cultured dermal fibroblasts (manufactured by Kurabo) are cultured in serum-containing Medium 106 liquid medium (manufactured by ThermoFisher Scientific) in a 96-well microplate, and then each concentration (0, 10 -8 ) in serum-free medium , 10 ⁇ 6 , 10 ⁇ 4 w / v%) was exchanged to adenosine diphosphate disodium (AMP 2 Na) prepared. This was cultured at 37 ° C., 5% CO 2 for 48 and 96 hours.
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Abstract
Description
特許文献2、特許文献3、特許文献4にはウリジン一リン酸が他の有効成分の増強剤として使用されることが開示されているが、これらの文献いずれにもウリジン一リン酸が単独で有効成分として機能することは開示されていない。
[1] ウリジンのリン酸エステルまたはその生理学的に許容される塩を、保湿、抗シワ、抗たるみ、創傷治療、脱毛の防止、育毛、またはアトピー性皮膚炎の予防/治療のための有効成分として含有することを特徴とする、外用組成物。
[2] 該ウリジンのリン酸エステルまたはその生理学的に許容される塩を単独の有効成分として含む、[1]に記載の組成物。
[3] 保湿、抗シワ、抗たるみ、創傷治療、脱毛の防止、育毛、またはアトピー性皮膚炎の予防/治療のための他の有効成分を有効量含まない、[1]または[2]に記載の組成物。
[4] 該ウリジンのリン酸エステルまたはその生理学的に許容される塩が、ウリジン一リン酸、ウリジン二リン酸、ウリジン三リン酸、またはそれらの生理学的に許容される塩から選択される、[1]~[3]のいずれか1項に記載の組成物。
[5] 該ウリジンのリン酸エステルまたはその生理学的に許容される塩が、ウリジン一リン酸またはその生理学的に許容される塩から選択される、[1]~[4]のいずれか1項に記載の組成物。
[6] 該ウリジンのリン酸エステルまたはその生理学的に許容される塩が、ウリジン5’-リン酸またはその生理学的に許容される塩から選択される、[1]~[5]のいずれか1項に記載の組成物。
[7] 該組成物が皮膚に使用される外用組成物である、[1]~[6]のいずれか1項に記載の組成物。
[8] 該組成物が細胞増殖を促進する用途のためにまたはヒアルロン酸産生を促進する用途のために使用される、[1]~[7]のいずれか1項に記載の組成物。
[9] 化粧料、外用医薬品、または外用医薬部外品である、[1]~[8]のいずれか1項に記載の組成物。
[11] 該ウリジンのリン酸エステルまたはその生理学的に許容される塩を単独の有効成分として含む、[10]に記載の組成物。
[12] 細胞増殖促進またはヒアルロン酸産生促進のための他の有効成分を有効量含まない、[10]または[11]に記載の組成物。
[13] 該ウリジンのリン酸エステルまたはその生理学的に許容される塩が、ウリジン一リン酸、ウリジン二リン酸、ウリジン三リン酸、またはそれらの生理学的に許容される塩から選択される、[10]~[12]のいずれか1項に記載の組成物。
[14] 該ウリジンのリン酸エステルまたはその生理学的に許容される塩が、ウリジン一リン酸またはその生理学的に許容される塩から選択される、[10]~[13]のいずれか1項に記載の組成物。
[15] 該ウリジンのリン酸エステルまたはその生理学的に許容される塩が、ウリジン5’-リン酸またはその生理学的に許容される塩から選択される、[10]~[14]のいずれか1項に記載の組成物。
[16] 該組成物が皮膚に使用される外用組成物である、[10]~[15]のいずれか1項に記載の組成物。
[17] 保湿、抗シワ、抗たるみ、創傷治療、脱毛の防止、育毛、またはアトピー性皮膚炎の予防/治療から選択される用途のために使用される、[10]~[16]のいずれか1項に記載の組成物。
[18] 保湿、抗シワ、抗たるみ、創傷治療、脱毛の防止、育毛、またはアトピー性皮膚炎の予防/治療のための他の有効成分を有効量含まない、[17]に記載の組成物。
[19] 化粧料、外用医薬品、または外用医薬部外品である、[10]~[18]のいずれか1項に記載の組成物。
(1)皮膚の保湿を高める
(2)シワを抑制する
(3)たるみを抑制する
(4)創傷を治療する
(5)脱毛を防止する
(6)育毛を促進する
(7)アトピー性皮膚炎を予防/治療する
(8)細胞の増殖を促進する
(9)ヒアルロン酸の産生を促進する
から選択される目的のために使用される方法。
本明細書において「保湿、抗シワ、抗たるみ、創傷治療、脱毛の防止、育毛、またはアトピー性皮膚炎の予防/治療のための他の有効成分」とは保湿、抗シワ、抗たるみ、創傷治療、脱毛の防止、育毛、またはアトピー性皮膚炎の予防/治療のための有効成分として知られる、ウリジンのリン酸エステルまたはその生理学的に許容される塩以外の成分を意味する。
本明細書において「細胞増殖促進またはヒアルロン酸産生促進のための他の有効成分」とは細胞増殖促進またはヒアルロン酸産生促進のための有効成分として知られる、ウリジンのリン酸エステルまたはその生理学的に許容される塩以外の成分を意味する。
好ましい塩はナトリウム塩などのアルカリ金属塩である。かかるアルカリ金属塩の例として、ウリジン一リン酸一ナトリウム、およびウリジン一リン酸二ナトリウム(以下、UMP2Na)が挙げられる。
本願の組成物に含まれるウリジンのリン酸エステルまたはその生理学的に許容される塩の含量の上限値の更なる例として、該組成物の総重量に対して、好ましくは10重量%、7重量%、5重量%、3重量%、および2重量%、および特に好ましくは1重量%が挙げられる。
本願の組成物に含まれるウリジンのリン酸エステルまたはその生理学的に許容される塩の含量の下限値の更なる例として、該組成物の総重量に対して、好ましくは0.01重量%、0.05重量%、0.1重量%、0.5重量%、および0.7重量%、および特に好ましくは1重量%が挙げられる。
育毛とは、産毛を含め既存の毛が健康に育つことを意味し、新しい毛の生成が促進されることも含まれる。脱毛の予防とは、既存の毛が抜けることを防ぐことを意味する。
の化合物である。
上記の塩は、ナトリウム塩やカリウム塩などのアルカリ金属塩;カルシウム塩、マグネシウム塩およびバリウム塩等のアルカリ土類金属塩;アルギニンやリジン等の塩基性アミノ酸塩;アンモニウム塩やトリシクロヘキシルアンモニウム塩等のアンモニウム塩;モノエタノールアミン塩、ジエタノールアミン塩、トリエタノールアミン塩、モノイソプロパノールアミン塩、ジイソプロパノールアミン塩およびトリイソプロパノールアミンなどのアルカノールアミン塩である。
本発明の方法において、上記物質の皮膚への適用は、簡便には、本願発明にかかる組成物を皮膚に塗布、噴霧又は貼付することにより行うことができる。
本発明の方法において、ウリジンのリン酸エステルまたはその生理学的に許容される塩を皮膚に適用する頻度および量については、特に制限されない。例えば、対象者の年齢、性別、期待される効果、皮膚症状の程度等に応じて、1回/日から5又は6回/日の回数で、適当量を皮膚に経皮的に適用される。具体的には、本願発明にかかる組成物を使用して本発明の方法を実施する場合であれば、例えば適用される皮膚の面積に対する該組成物の適用割合が0.5~10mg/cm2の範囲となるような量を1回適用量の目安とすることができる。本発明の方法の使用期間は限定されるものではないが、細胞増殖促進およびヒアルロン酸産生促進を効果的に持続させるために継続的に使用することが好ましく、例えば1箇月(好ましくは2箇月間以上)使用されうる。
UMP2Na 3.0(重量%)
ポリオキシエチレン(E.O.60)硬化ヒマシ油 0.7
エタノール 5.0
グリセリン 2.0
防腐剤 適量
香料 適量
pH調整剤 適量
精製水 残余
合 計 100.0重量%
常法にしたがって、上記処方の化粧水を調製する。
UMP2Na 1.5(重量%)
カルボキシビニルポリマー 0.3
モノミリスチン酸デカグリセリン 2.0
スクワラン 5.0
エタノール 1.0
グリセリン 6.0
防腐剤 適量
pH調整剤 適量
精製水 残余
合 計 100.0重量%
UMP2Na 3(重量%)
ポリオキシエチレンポリオキシプロピレン
デシルテトラデシルエーテル 0.5
エタノール 30
1,3-ブチレングリコール 2.5
防腐剤 適量
香料 適量
pH調整剤 適量
精製水 残余
合 計 100.0重量%
常法にしたがって、上記処方の育毛剤を調製する。
前培養した初代培養ヒト表皮角化細胞(クラボウ社製)を96ウェルマイクロプレートにて、増殖因子含有EpiLife液体培地(ThermoFisher Scientific社製)で培養後、増殖因子不含培地にて各濃度(0、10-6、10-5、10-4、10-3、10-2mol/L)に調製したUMP2Naまたはウリジン溶液に交換した。
前培養した初代培養真皮線維芽細胞(クラボウ社製)を96ウェルマイクロプレートにて、血清含有Medium106液体培地(ThermoFisher Scientific社製)で培養後、無血清培地にて各濃度(0、10-6、10-5、10-4、10-3、10-2mol/L)に調製したUMP2Naまたはウリジン溶液に交換した。
これらを37℃、5%CO2の条件下で48および72時間培養した。培養後、各ウェル中の培養上清を回収し、当該培養上清中のヒアルロン酸量を、ヒアルロン酸定量キット(コスモバイオ社製)を用いて検出し、マイクロプレートリーダーにて測定した。
図1に表皮角化細胞の結果を示す。
図2に真皮線維芽細胞の結果を示す。
前培養した初代培養ヒト皮膚線維芽細胞(クラボウ社製)を96ウェルマイクロプレートにて、血清含有Medium106液体培地(ThermoFisher Scientific社製)で培養し、接着安定化後に同培地にて各濃度(0、10-6、10-5、10-4、10-3、10-2mol/L)に調製したUMP2Naまたはウリジン溶液に交換した。これを37℃、5%CO2の条件下で48、72および96時間培養した。各時間培養後、各ウェル中の細胞数をWST-1試薬(タカラバイオ社製)を用いて検出後、マイクロプレートリーダーにて測定した。
結果を図3に示す。
前培養した初代培養ヒト毛乳頭細胞(タカラバイオ社製)を96ウェルマイクロプレートにて、毛乳頭細胞増殖培地(タカラバイオ社製)で培養し、接着安定化後に各種濃度に調製した薬剤含有試験培地に交換した。これを37℃、5%CO2の条件下で72、96及び120時間培養した。各時間培養後に細胞核を染色し、各ウェル中の細胞数のカウントを行った。
結果を図4に示す。
前培養した初代培養真皮線維芽細胞(クラボウ社製)を96ウェルマイクロプレートにて、血清含有Medium106液体培地(ThermoFisher Scientific社製)で培養後、無血清培地にて各濃度(0、10-8、10-6、10-4w/v%)に調製したアデノシン一リン酸二ナトリウム(AMP2Na)に交換した。
これを37℃、5%CO2の条件下で48および96時間培養した。培養後、各ウェル中の培養上清を回収し、当該培養上清中のヒアルロン酸量を、ヒアルロン酸定量キット(コスモバイオ社製)を用いて検出し、マイクロプレートリーダーにて測定した。
結果を図5に示す。
Claims (19)
- ウリジンのリン酸エステルまたはその生理学的に許容される塩を、保湿、抗シワ、抗たるみ、創傷治療、脱毛の防止、育毛、またはアトピー性皮膚炎の予防/治療のための有効成分として含有することを特徴とする、外用組成物。
- 該ウリジンのリン酸エステルまたはその生理学的に許容される塩を単独の有効成分として含む、請求項1に記載の組成物。
- 保湿、抗シワ、抗たるみ、創傷治療、脱毛の防止、育毛、またはアトピー性皮膚炎の予防/治療のための他の有効成分を有効量含まない、請求項1または2に記載の組成物。
- 該ウリジンのリン酸エステルまたはその生理学的に許容される塩が、ウリジン一リン酸、ウリジン二リン酸、ウリジン三リン酸、またはそれらの生理学的に許容される塩から選択される、請求項1~3のいずれか1項に記載の組成物。
- 該ウリジンのリン酸エステルまたはその生理学的に許容される塩が、ウリジン一リン酸またはその生理学的に許容される塩から選択される、請求項1~4のいずれか1項に記載の組成物。
- 該ウリジンのリン酸エステルまたはその生理学的に許容される塩が、ウリジン5’-リン酸またはその生理学的に許容される塩から選択される、請求項1~5のいずれか1項に記載の組成物。
- 該組成物が皮膚に使用される外用組成物である、請求項1~6のいずれか1項に記載の組成物。
- 該組成物が細胞増殖を促進する用途のためにまたはヒアルロン酸産生を促進する用途のために使用される、請求項1~7のいずれか1項に記載の組成物。
- 化粧料、外用医薬品、または外用医薬部外品である、請求項1~8のいずれか1項に記載の組成物。
- ウリジンのリン酸エステルまたはその生理学的に許容される塩を細胞増殖促進またはヒアルロン酸産生促進のための有効成分として含有することを特徴とする、外用組成物。
- 該ウリジンのリン酸エステルまたはその生理学的に許容される塩を単独の有効成分として含む、請求項10に記載の組成物。
- 細胞増殖促進またはヒアルロン酸産生促進のための他の有効成分を有効量含まない、請求項10または11に記載の組成物。
- 該ウリジンのリン酸エステルまたはその生理学的に許容される塩が、ウリジン一リン酸、ウリジン二リン酸、ウリジン三リン酸、またはそれらの生理学的に許容される塩から選択される、請求項10~12のいずれか1項に記載の組成物。
- 該ウリジンのリン酸エステルまたはその生理学的に許容される塩が、ウリジン一リン酸またはその生理学的に許容される塩から選択される、請求項10~13のいずれか1項に記載の組成物。
- 該ウリジンのリン酸エステルまたはその生理学的に許容される塩が、ウリジン5’-リン酸またはその生理学的に許容される塩から選択される、請求項10~14のいずれか1項に記載の組成物。
- 該組成物が皮膚に使用される外用組成物である、請求項10~15のいずれか1項に記載の組成物。
- 保湿、抗シワ、抗たるみ、創傷治療、脱毛の防止、育毛、またはアトピー性皮膚炎の予防/治療から選択される用途のために使用される、請求項10~16のいずれか1項に記載の組成物。
- 保湿、抗シワ、抗たるみ、創傷治療、脱毛の防止、育毛、またはアトピー性皮膚炎の予防/治療のための他の有効成分を有効量含まない、請求項17に記載の組成物。
- 化粧料、外用医薬品、または外用医薬部外品である、請求項10~18のいずれか1項に記載の組成物。
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KR1020207004649A KR20200031665A (ko) | 2017-07-24 | 2018-07-23 | 외용 조성물 |
JP2019532585A JP7300988B2 (ja) | 2017-07-24 | 2018-07-23 | 外用組成物 |
CN201880049180.9A CN110944622A (zh) | 2017-07-24 | 2018-07-23 | 外用组合物 |
AU2018307389A AU2018307389A1 (en) | 2017-07-24 | 2018-07-23 | Topical composition |
US16/633,076 US20210154122A1 (en) | 2017-07-24 | 2018-07-23 | Topical composition |
EP18839236.9A EP3659581A4 (en) | 2017-07-24 | 2018-07-23 | TOPICAL COMPOSITION |
PH12020500170A PH12020500170A1 (en) | 2017-07-24 | 2020-01-23 | Topical composition |
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US (1) | US20210154122A1 (ja) |
EP (1) | EP3659581A4 (ja) |
JP (1) | JP7300988B2 (ja) |
KR (1) | KR20200031665A (ja) |
CN (1) | CN110944622A (ja) |
AU (1) | AU2018307389A1 (ja) |
PH (1) | PH12020500170A1 (ja) |
SG (1) | SG11202000615VA (ja) |
TW (1) | TW201907902A (ja) |
WO (1) | WO2019021988A1 (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023058731A1 (ja) | 2021-10-07 | 2023-04-13 | ヤマサ醤油株式会社 | 皮膚外用組成物及びその利用、並びに皮膚外用組成物原料 |
WO2023191015A1 (ja) * | 2022-03-30 | 2023-10-05 | ヤマサ醤油株式会社 | コラーゲン産生促進剤、化粧料組成物又は皮膚外用剤、及び経口投与剤 |
WO2023191016A1 (ja) * | 2022-03-30 | 2023-10-05 | ヤマサ醤油株式会社 | フィブリリン産生促進剤、化粧料組成物又は皮膚外用剤、経口投与剤、及びエラスチン線維産生促進剤 |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20230248628A1 (en) * | 2020-06-30 | 2023-08-10 | Institute Of Rheological Function Of Food Co., Ltd. | Composition for hair growth and/or hair restoration |
CN114469981A (zh) * | 2021-12-16 | 2022-05-13 | 中国科学院动物研究所 | 尿苷在促进组织器官再生或治疗和/或预防和/或缓解和/或改善组织器官损伤中的应用 |
WO2024005737A1 (en) * | 2022-12-20 | 2024-01-04 | Bursa Uludağ Üni̇versi̇tesi̇ | Nanofiber wound dressing with uridine |
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- 2018-07-23 KR KR1020207004649A patent/KR20200031665A/ko not_active Application Discontinuation
- 2018-07-23 JP JP2019532585A patent/JP7300988B2/ja active Active
- 2018-07-23 EP EP18839236.9A patent/EP3659581A4/en not_active Withdrawn
- 2018-07-23 AU AU2018307389A patent/AU2018307389A1/en not_active Abandoned
- 2018-07-23 WO PCT/JP2018/027449 patent/WO2019021988A1/ja unknown
- 2018-07-23 US US16/633,076 patent/US20210154122A1/en not_active Abandoned
- 2018-07-23 CN CN201880049180.9A patent/CN110944622A/zh active Pending
- 2018-07-23 SG SG11202000615VA patent/SG11202000615VA/en unknown
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WO2023058731A1 (ja) | 2021-10-07 | 2023-04-13 | ヤマサ醤油株式会社 | 皮膚外用組成物及びその利用、並びに皮膚外用組成物原料 |
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Also Published As
Publication number | Publication date |
---|---|
JPWO2019021988A1 (ja) | 2020-07-02 |
TW201907902A (zh) | 2019-03-01 |
KR20200031665A (ko) | 2020-03-24 |
AU2018307389A1 (en) | 2020-02-20 |
EP3659581A1 (en) | 2020-06-03 |
EP3659581A4 (en) | 2020-12-16 |
SG11202000615VA (en) | 2020-02-27 |
JP7300988B2 (ja) | 2023-06-30 |
US20210154122A1 (en) | 2021-05-27 |
PH12020500170A1 (en) | 2020-10-12 |
CN110944622A (zh) | 2020-03-31 |
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