WO2019015085A1 - 一种用于治疗闭经的中药 - Google Patents

一种用于治疗闭经的中药 Download PDF

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WO2019015085A1
WO2019015085A1 PCT/CN2017/103069 CN2017103069W WO2019015085A1 WO 2019015085 A1 WO2019015085 A1 WO 2019015085A1 CN 2017103069 W CN2017103069 W CN 2017103069W WO 2019015085 A1 WO2019015085 A1 WO 2019015085A1
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chinese medicine
traditional chinese
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grams
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王淑英
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淄博齐鼎立专利信息咨询有限公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A61K36/296—Epimedium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/43—Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/533—Leonurus (motherwort)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/68—Plantaginaceae (Plantain Family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/79—Schisandraceae (Schisandra family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Definitions

  • the invention relates to a traditional Chinese medicine, in particular to a traditional Chinese medicine for treating amenorrhea.
  • Amenorrhea is a common symptom in gynecological diseases, usually divided into primary and secondary according to the time of amenorrhea. Those who are in temperate zone and who are over 18 years old and have not yet had menstruation are called primary amenorrhea. After the menstrual cycle is established, non-physiological menopause reaches or exceeds three months, which is called secondary amenorrhea.
  • the periodic changes in the endometrium are caused by periodic changes in the ovary.
  • the normal function of the ovary is regulated by gonadotropins secreted by the anterior pituitary gland, while the gonadotropin secreted by the pituitary gland is secreted by the hypothalamic gonadotropin. Release of hormone and prolactin inhibitors. For this reason, any part of the hypothalamic-pituitary-ovarian axis is disturbed, which can lead to menstrual disorders and amenorrhea.
  • Dodder (alias) bean parasitic, no root grass, yellow silk, yellow silk vine, no vine, golden silk.
  • This product is a dry mature seed of the Convolvulaceae plant. When the autumn fruit matures, the plants are harvested, dried, and seeds are removed to remove impurities. [Sexual taste] sweet, warm. [Return] to the liver, kidney, spleen. ⁇ Indications ⁇ nourish liver and kidney, solidify and urinate, fetus, eyesight, diarrhea.
  • This product is the dried fruit of R. sylvestris var. At the beginning of the summer, the fruit is harvested from green to greenish yellow. Remove the stems, leaves, set the boiling water slightly hot or slightly steamed, take out, and dry. [Sexual taste] sweet, sour, warm. [Return] to the kidney, bladder. [Indications] Yishen, solid essence, urinary. For kidney deficiency enuresis, frequency of urination, impotence and premature ejaculation, spermatorrhea and spermatorrhea. [Usage and dosage] Oral: Jiantang, 6 ⁇ 12g. [Note] There is a fire in the kidney, and the person with short urine is cautious. [Excerpt] "Chinese Materia Medica”.
  • Psyllium [alias] car front, shrimp ⁇ clothes, pig ears tassels, phoenix eyes before the kernel.
  • Source This product is a dry mature seed in front of a car or in front of a flat car. In the summer and autumn, when the seeds are ripe, the ears are harvested, dried, and the seeds are removed to remove impurities.
  • Supplemental taste sweet, slightly cold.
  • Return to the liver, kidney, lung, small intestine.
  • Clearing heat and diuresis seeping and drenching, eyesight, and phlegm. For edema fullness, hot dripping pain, summer damp diarrhea, red eyes and swelling, hot cough.
  • Epimedium [alias] three branches of shamrock, fairy spleen, horn flower, trigeminal, shofar wind, triangle lotus. [Source] This product is a dry aerial part of Epimedium, Epimedium, Atractylodes, Epimedium, Wushan Epimedium, or Korean Epimedium. Harvesting in summer and autumn when the leaves are flourishing And impurities, dried or dried. [Sexual taste] Xin, Gan, warm. [Return] to the liver, kidney. [Indications] Bushenyang, strong bones, rheumatism. For impotence and nocturnal emission, soft bones, rheumatism, numbness, numbness; menopausal hypertension.
  • Achyranthes [alias] Achyranthes, Astragalus, Amaranth, Acacia, Red Bull Knee, Du Niu Knee, Achyranthes [wild product].
  • This product is the dry root of Achyranthes. When the stems and leaves are withered in winter, the roots and sediments are removed, bundled into small pieces, and after drying to dry wrinkles, the tops are cut and dried. [Sexual taste] bitter, sour, flat. [Return] to the liver, kidney. ⁇ Indications ⁇ Invigorate the liver and kidney, strengthen the bones and muscles, pass through the sputum, and lead the blood. For waist and knee pain, weak bones, menstrual cramps, liver stun. [Usage and dosage] Oral: Jiantang, 4.5 ⁇ 9g. [Note] Pregnant women should use it with caution. [Excerpt] "Chinese Materia Medica”.
  • Angelica [alias] dry back.
  • This product is the dried root of Angelica sinensis. At the end of autumn, the excavation is carried out to remove the roots and sediments. After the water has evaporated slightly, it is bundled into small pieces and placed on the shed, and slowly dried out with fireworks.
  • Gan, Xin, Wen. [Return to the classics] to the liver, heart, spleen.
  • the invention aims to provide a traditional Chinese medicine for treating amenorrhea, and achieve the purpose of safe and effective cure of amenorrhea by selecting an appropriate medicine and its ratio.
  • the traditional Chinese medicine for treating amenorrhea is characterized in that it is prepared from the following raw materials of weight ratio: 15 parts of dodder, 10 parts of raspberry, 15 parts of hazelnut, 10 parts of Schisandra, 10 parts of Psyllium 10 parts of Epimedium, 9 parts of Achyranthes, 20 parts of Motherwort, 12 parts of Dioscorea, 10 parts of Angelica
  • the treatment group aged 16 to 43 years, with an average age of 31 years, duration of disease 6 Months to 12 years; control group, age 16 to 545 years, mean age 32 years, duration of disease, 5 months to 11 years; There was no significant difference in age and duration of disease between the two groups, which was comparable.
  • Symptoms In addition to menstrual closure, mainly manifested as symptoms of the disease, such as chronic wasting disease, manifested as lack of energy, extreme exhaustion, significant weight loss, etc.; , it is characterized by fever, night sweats, weakness, loss of appetite, weight loss, etc.; but genital tuberculosis, systemic symptoms are not obvious, such as mental factors, there are neurasthenia and nervous tendencies.
  • Signs In order to determine the primary disease, a full physical examination should be performed.
  • amenorrhea caused by chronic wasting disease may have signs of anemia, malnutrition, etc.; amenorrhea caused by tuberculosis, sometimes signs are not obvious; amenorrhea caused by diabetes may be obese, usually by means of other Auxiliary examination and special examination to confirm the diagnosis.
  • Gynecological examination Most of them have no obvious pelvic organic lesions; sometimes there may be atrophy of reproductive organs. 2, test methods
  • the treatment group was orally administered the capsule prepared according to the specific example 3 of the present invention 3 times a day.
  • the treatment lasts for one month.
  • the control group received oral clomiphene, 3 times / day, supplement Jiahe 0.1g, 1 time / day. The treatment lasts for one month.
  • the medicine prepared by the invention can safely and effectively treat amenorrhea and has the promotion value.

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  • Health & Medical Sciences (AREA)
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Abstract

一种治疗闭经的中药，它是由以下重量配比的原料药材制备而成：菟丝子15份、覆盆子10份、枸杞子15份、五味子10份、车前子10份、淫羊藿10份、牛膝9份、益母草20份、续断12份、当归10份。

Description

一种用于治疗闭经的中药 技术领域
本发明涉及一种中药，具体涉及一种用于治疗闭经的中药。
背景技术
闭经是妇科疾病中常见的症状，通常按闭经出现的时间分为原发性和继发性两类。凡地处温带，年逾18周岁而月经尚未来潮者，称为原发性闭经；而在月经周期建立以后，非生理性停经达到或超过三个月者，称为继发性闭经。子宫内膜周期性的变化是由卵巢周期性变化引起的，卵巢的正常功能是由脑垂体前叶分泌的促性腺激素所调节，而垂体分泌的促性腺激素又受下丘脑分泌的促性腺激素释放激素和催乳素抑制因子的控制。为此，下丘脑-垂体-卵巢轴中任何一个环节受到干扰，均可导致月经紊乱，以至闭经。
中医将闭经分为虚、实两类。虚者多因先天不足或后天损伤，致经源匮乏，血海空虚，无余可下；实者多因邪气阻隔，胞脉壅塞，冲任阻滞，血海不满不溢。闭经的辨证，必须与详细询问病史及全面检查相结合，辨证的重点在于分清虚实。凡已逾初潮年龄尚未行经，或月经渐发后期、量渐少而终至闭经，并伴有头晕肢软，心悸失眠，时或腰酸，形体清瘦者为血枯虚证；凡以往月经之周期，经量尚属正常而突发经闭，并伴胸腹胀满，小腹胀痛，形体肥胖壮实者，为血滞实证。临床上以虚证或本虚标实者为多见。临证常分为肝肾不足、气血虚弱、阴虚血燥、气滞血瘀、痰湿阻滞五型。
本发明所涉及药材研究现状如下：
菟丝子【别名】豆寄生、无根草、黄丝、黄丝藤、无娘藤、金黄丝子。【来源】本品为旋花科植物菟丝子的干燥成熟种子。秋季果实成熟时采收植株，晒干，打下种子，除去杂质。【性味】甘，温。【归经】归肝、肾、脾经。【功能主治】滋补肝肾，固精缩尿，安胎，明目，止泻。用于阳痿遗精，尿有余沥，遗尿尿频，腰膝酸软，目昏耳鸣，肾虚胎漏，胎动不安，脾肾虚泻；外治白癜风。【用法用量】内服：煎汤，6～12g。【注意】得酒良。薯蓣、松脂为之使，恶藋菌。肾家多火，强阳不痿者忌之，大便燥结者亦忌之。【摘录】《中华本草》。
覆盆子【别名】覆盆，乌藨子，小托盘，竻藨子。【来源】本品为蔷薇科悬钩子属植物华东覆盆子的干燥果实。夏初果实由绿变绿黄时采收，除 去梗、叶，置沸水中略烫或略蒸，取出，干燥。【性味】甘、酸，温。【归经】归肾、膀胱经。【功能主治】益肾，固精，缩尿。用于肾虚遗尿，小便频数，阳痿早泄，遗精滑精。【用法用量】内服：煎汤，6～12g。【注意】肾虚有火，小便短涩者慎服。【摘录】《中华本草》。
枸杞子【别名】苟起子、甜菜子、杞子、红青椒、构蹄子、狗奶子、枸杞果、地骨子、枸茄茄、红耳坠、血枸子、枸地芽子、枸杞豆、血杞子。【来源】晒干本品为茄科植物宁夏枸杞的干燥成熟果实。夏、秋二季果实呈红色时采收，热风烘干，除去果梗。或晾至皮皱后，晒干，除去果梗。【性味】甘，平。【归经】归肝、肾经。【功能主治】滋补肝肾，益精明目。用于虚劳精亏，腰膝酸痛，眩晕耳鸣，内热消渴，血虚萎黄，目昏不明。【用法用量】内服：煎汤，6～12g。【注意】外邪实热，脾虚有湿及泄泻者忌服。【摘录】《中华本草》五味子【别名】菋、荎蕏，玄及，会及，五梅子、北五味子、辽五味子。【来源】本品为木兰科植物五味子或华中五味子的干燥成熟果实。前者习称“北五味子”，后者习称“南五味子”。秋季果实成熟时采摘，晒干或蒸后晒干，除去果梗及杂质。【性味】酸、甘，温。【归经】归肺，心、肾经。【功能主治】收敛固涩，益气生津，补肾宁心。用于久嗽虚喘，梦遗滑精，遗尿尿频，久泻不止，自汗，盗汗，津伤口渴，短气脉虚，内热消渴，心悸失眠。【用法用量】内服：煎汤，3～12g。【注意】外有表邪，内有实热，或咳嗽初起、痧疹初发者忌服。【摘录】《中华本草》。
车前子【别名】车前实，虾蟆衣子，猪耳朵穗子，凤眼前仁。【来源】本品为车前科植物车前或平车前的干燥成熟种子。夏、秋二季种子成熟时采收果穗，晒干，搓出种子，除去杂质。【性味】甘，微寒。【归经】归肝、肾、肺、小肠经。【功能主治】清热利尿，渗湿通淋，明目，祛痰。用于水肿胀满，热淋涩痛，暑湿泄泻，目赤肿痛，痰热咳嗽。【用法用量】内服：煎汤，9～15g。【注意】凡内伤劳倦，阳气下陷，肾虚精滑及内无湿热者，慎服。【摘录】《中华本草》。
淫羊藿【别名】三枝九叶草、仙灵脾、牛角花、三叉风、羊角风、三角莲。【来源】本品为小檗科植物淫羊藿、箭叶淫羊藿、柔毛淫羊藿、巫山淫羊藿、或朝鲜淫羊藿的干燥地上部分。夏、秋季茎叶茂盛时采割，除去粗梗 及杂质，晒干或阴干。【性味】辛、甘，温。【归经】归肝、肾经。【功能主治】补肾阳，强筋骨，祛风湿。用于阳痿遗精，筋骨痿软，风湿痹痛，麻木拘挛；更年期高血压。【用法用量】内服：煎汤，3～9g。【注意】虚阳易举，梦遗不止，便赤口干，强阳不痿并忌之。【摘录】《中华本草》。
牛膝【别名】怀牛膝、牛髁膝、山苋菜、对节草、红牛膝、杜牛膝、土牛膝[野生品]。【来源】本品为苋科植物牛膝的干燥根。冬季茎叶枯萎时采挖，除去须根及泥沙，捆成小把，晒至干皱后，将顶端切齐，晒干。【性味】苦、酸，平。【归经】归肝、肾经。【功能主治】补肝肾，强筋骨，逐瘀通经，引血下行。用于腰膝酸痛，筋骨无力，经闭症瘕，肝阳眩晕。【用法用量】内服：煎汤，4.5～9g。【注意】孕妇慎用。【摘录】《中华本草》。
益母草【别名】益母蒿、益母艾、红花艾、坤草、茺蔚、三角胡麻、四楞子棵。【来源】本品为唇形科植物益母草的新鲜或干燥地上部分。鲜品春季幼苗期至初夏花前期采割；干品夏季茎叶茂盛、花未开或初开时采割，晒干，或切段晒干。【性味】苦、辛，微寒。【归经】归肝、心包经。【功能主治】活血调经，利尿消肿。用于月经不调，痛经，经闭，恶露不尽，水肿尿少；急性肾炎水肿。【用法用量】内服：煎汤，9-30g。【注意】孕妇禁用。【摘录】《中华本草》。
续断【别名】川续断、和尚头、山萝卜。【来源】本品为川续断科植物川续断的干燥根。秋季采挖，除去根头及须根，用微火烘至半干，堆置“发汗”至内部变绿色时，再烘干。【性味】苦、辛，微温。【归经】归肝、肾经。【功能主治】补肝肾，强筋骨，续折伤，止崩漏。用于腰膝酸软，风湿痹痛，崩漏，胎漏，跌扑损伤。酒续断多用于风湿痹痛，跌扑损伤。盐续断多用于腰膝酸软。【用法用量】内服：煎汤，9～15g。【注意】初痢勿用，怒气郁者禁用。【摘录】《中华本草》。
当归【别名】干归。【来源】本品为伞形科植物当归的干燥根。秋末采挖，除去须根及泥沙，待水分稍蒸发后，捆成小把，上棚，用烟火慢慢熏干。【性味】甘、辛，温。【归经】归肝、心、脾经。【功能主治】补血活血，调经止痛，润肠通便。用于血虚萎黄，眩晕心悸，月经不调，经闭痛经，虚寒腹痛，肠燥便秘，风湿痹痛，跌扑损伤，痈疽疮疡。酒当归活血通经。用于经闭痛经，风湿痹痛，跌扑损伤。【用法用量】内服：煎汤，10～25g。【注意】湿阻中满及 大便溏泄者慎服。【摘录】《中华本草》。
发明内容
本发明旨在提供一种用于治疗闭经的中药，通过选择合适的药材及其配比，达到安全有效治愈闭经的目的。
为了达到上述目的，本发明采用以下技术方案：
一种用于治疗闭经的中药，其特征在于，它是由以下重量配比的原料药材制备而成：菟丝子15份、覆盆子10份、枸杞子15份、五味子10份、车前子10份、淫羊藿10份、牛膝9份、益母草20份、续断12份、当归10份
。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2012年10月～2013年10月间共收集门诊及住院闭经患者188例，随机分为治疗组108例与对照组80，治疗组，年龄16～43岁，平均年龄31岁，病程6个月～12年；对照组，年龄16～545岁，平均年龄32岁，病程,5个月～11年；。2组年龄及病程比较差异无统计学意义，具有可比性。
诊断标准
依据全国闭经临床专业会议的诊断标准：(1)症状：除月经闭止外，主要表现为所致疾病的症状，如慢性消耗性疾病，表现为精神不振、极度衰竭、明显消瘦等；如结核病，则表现为发热、盗汗、无力、食欲不振、体重减轻等；但生殖道结核，全身症状多不明显，如精神因素所致者，则有神经衰弱及神经质倾向。(2)体征：为确定原发性疾病，应作全身体检。全身检查：慢性消耗性疾病所致的闭经，可有贫血、营养不良等体征；结核病所致的闭经，有时体征并不明显；糖尿病所致的闭经，则可能有过度肥胖，通常需借助于其他辅助检查及特殊检查确诊。(3)妇科检查：大多无明显盆腔器质性病变；有时可有生殖器官萎缩现象。2、试验方法
2.1治疗方法
治疗组口服本发明按照具体实施例3制得的胶囊剂，每日3次。疗程一个月。
对照组口服氯米芬，3次/天，补佳禾0.1g，1次/天。疗程一个月。
3、疗效标准与治疗结果
3.1疗效标准
临床控制：临床症状、体征等完全消失；
显效：临床症状、体征等明显好转；
有效：临床症状、体征等有所好转；
无效：临床症状、体征等与用药前没有变化。
3.2治疗结果见表1。
表1两组疗效比较
Figure PCTCN2017103069-appb-000001
可见，本发明制得的药物能够安全有效治疗闭经，具有推广价值。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
实施例1
称取：菟丝子15克、覆盆子10克、枸杞子15克、五味子10克、车前子10克、淫羊藿10克、牛膝9克、益母草20克、续断12克、当归10克；加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩至120克，即得符合正常成人一天用量的煎剂。
用于治疗闭经。口服，每日分早午晚三次服用。
实施例2
称取：菟丝子15克、覆盆子10克、枸杞子15克、五味子10克、车前子10克、淫羊藿10克、牛膝9克、益母草20克、续断12克、当归10克；加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得符合正常成人一天用量的散剂。
用于治疗闭经。口服，每日分早午晚三次服用。
实施例3
称取：菟丝子15克、覆盆子10克、枸杞子15克、五味子10克、车前子10克、 淫羊藿10克、牛膝9克、益母草20克、续断12克、当归10克；加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，干燥，装入胶囊壳，即得符合正常成人一天用量的胶囊剂。
用于治疗闭经。口服，每日分早午晚三次服用。

Claims (4)

  1. 一种用于治疗闭经的中药，其特征在于，它是由以下重量配比的原料药材制备而成：菟丝子15份、覆盆子10份、枸杞子15份、五味子10份、车前子10份、淫羊藿10份、牛膝9份、益母草20份、续断12份、当归10份。
  2. 如权利要求1所述的用于治疗闭经的中药，其特征在于，其制备方法为：称取：菟丝子15份、覆盆子10份、枸杞子15份、五味子10份、车前子10份、淫羊藿10份、牛膝9份、益母草20份、续断12份、当归10份；加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩至120份，即得煎剂；上述份均是指重量份。
  3. 如权利要求1所述的用于治疗闭经的中药，其特征在于，其制备方法为：称取：菟丝子15份、覆盆子10份、枸杞子15份、五味子10份、车前子10份、淫羊藿10份、牛膝9份、益母草20份、续断12份、当归10份；加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得散剂；上述份均是指重量份。
  4. 如权利要求1所述的用于治疗闭经的中药，其特征在于，其制备方法为：称取：菟丝子15份、覆盆子10份、枸杞子15份、五味子10份、车前子10份、淫羊藿10份、牛膝9份、益母草20份、续断12份、当归10份；加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，干燥，装入胶囊壳，即得胶囊剂；上述份均是指重量份。
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CN1300625A (zh) * 1999-12-17 2001-06-27 内蒙古通辽制药厂 女士胶丸及其制造工艺
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CN1300625A (zh) * 1999-12-17 2001-06-27 内蒙古通辽制药厂 女士胶丸及其制造工艺
CN104740084A (zh) * 2015-04-16 2015-07-01 淄博夸克医药技术有限公司 一种用于治疗闭经的中药

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