WO2018196918A1 - Extraction et utilisation de polyphénols, en particulier d'acide chicorique, à partir de plantes du genre posidonia - Google Patents

Extraction et utilisation de polyphénols, en particulier d'acide chicorique, à partir de plantes du genre posidonia Download PDF

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Publication number
WO2018196918A1
WO2018196918A1 PCT/DE2018/100371 DE2018100371W WO2018196918A1 WO 2018196918 A1 WO2018196918 A1 WO 2018196918A1 DE 2018100371 W DE2018100371 W DE 2018100371W WO 2018196918 A1 WO2018196918 A1 WO 2018196918A1
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WO
WIPO (PCT)
Prior art keywords
posidonia
leaves
polyphenols
cichoric acid
juice
Prior art date
Application number
PCT/DE2018/100371
Other languages
German (de)
English (en)
Inventor
Matthias Spies
Roman Gehre
Original Assignee
Matthias Spies
Roman Gehre
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matthias Spies, Roman Gehre filed Critical Matthias Spies
Priority to DE112018002135.1T priority Critical patent/DE112018002135A5/de
Publication of WO2018196918A1 publication Critical patent/WO2018196918A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/884—Alismataceae (Water-plantain family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine

Definitions

  • the invention relates to a process for the recovery and use of polyphenols, in particular cichoric acid, from plants of the genus Posidonia r example, the kind Po ⁇ sidonia oceanica.
  • Food additives on the basis of polyphenols, in particular cichoric acid prepared from plants of the Gat ⁇ tung Echinacea, health-promoting properties are attributed. See, for example, WO 2001/022977.
  • the invention has recognized that the proportion of Polypheno ⁇ len, in particular the amount of cichoric acid, in the foliage leaves of the species Posidonia, particularly of the type Posidonia oceanica to be much higher than in Besag ⁇ th conventionally used as a starting material of plant material of the genus Echinacea ,
  • the proportion of cichoric in the freshly harvested leaves of Posidonia oceanica is at least 5% much higher than those of Echinacea purpura with only about 1%.
  • the proportion of polyphenols in the freshly harvested leaves of Posidonia oceanica is at least 7.5% we ⁇ significantly higher than those of Echinacea purpura with only about 2%.
  • the invention has further recognized that, in contrast to costly and expensive commercial cultivation for obtaining Echinacea plant biomass as a starting point for the production of polyphenols, in particular cichoric acid, these raw materials alternatively from the bungled leaves of the genus Posidonia r particular the type Posidonia oceanica r can be obtained. These foliage Leaves are flushed with the seawater to the beach and are available there in sufficient quantities without cultivation and harvesting effort.
  • the invention has recognized is further comprised of internal preliminary to the present application by the inventors that, surprisingly, a conventional in the art shredding ⁇ tion of the starting biomass prior to extraction leads to a reduction in Cichorienklafer. This is therefore surprising since the person skilled in the art actually assumes a contrary view, according to which a higher extraction yield is associated with increasing comminution and the associated digestion of the biomass.
  • the OF INVENTION ⁇ the have shown that the oxidation of the polyphenols, in particular the cichoric acid is favored at the comminution of the plant material with concomitant increase of the exposed to the air oxygen total surface area and thereby reduce the yield of cichoric acid ent ⁇ speaking.
  • the invention Since the accumulation of landed Posidonia leafy leaves for the balance of the ecosystem, inter alia, as part of the coastal protection in which the beach from erosion by the fibrous leaves of Posidonia is at least partially protected, are of considerable value, the invention has further recognized that the erfindungsge ⁇ Telss processed leaves the Posidonia r particular the Posidonia oceanica r after the recovery of press juice can continue to fulfill their coastal protection function.
  • the leaves of the Posidonia obtained from the beach or from beaches close to the beach are merely "borrowed” for the processing according to the invention and are structurally virtually unchanged after the pressing. neut for coastal protection or for further processing, for example as an insulating material (see, for example, EP 1 944 423 Bl) available.
  • the invention has recognized that in particular in the prevention of a mechanical comminution of the initial biomass, as is customary in conventional processes for Ge ⁇ winnung of ingredients from plants, and by dispensing with additives and fluids from ⁇ acquisition of fresh water, in particular by not übli ⁇ chumble organic Lö ⁇ solvents used in the prior art, the pressing residue (ie, the pressed leaves ⁇ leaves the Posidonia) allows an ecologically safe return ⁇ guide to the beach for the purpose of coast protection or further processing to corresponding pollution-free or low-emission intermediate or final products.
  • the invention is based on the objects to provide a process for the production of polyphenols, in particular cichoric acid, in which
  • this plant material originates from existing raw material sources, in particular plant material rejected by the plants themselves, without the need for cultivation or destruction or damage of the plants in the course of harvesting this plant material,
  • the invention is based on the surprising and randomly gained knowledge that the genus Posidonia, and in particular the species Posidonia oceanica and Posidoni australis are suitable for solving the abovementioned objects of the invention.
  • Polyphenols in the context of the present invention are natural aromatic compounds having at least two groups bonded to an aromatic ring hydroxyl groups and are derived from plants, including water plants Gattun Posidonia.
  • polyphenols including the cichoric acid, also Dicaffeoylwein Textre or Weinchu ⁇ redikaffeoylester called.
  • the claimed recovery process is based on a me ⁇ chanical pressing the Posidonia leaves. For the purpose of achieving the abovementioned objects, it has been found in the context of the invention that this is the best option for obtaining polyphenols, in particular cichoric acid, in particular with regard to the economic, sustainability and environmental aspects.
  • the mechanical pressure according to the invention can be carried out at mild temperatures and batchwise or continuously, for example using a screw press.
  • the erfindungsge ⁇ Gurss process at a temperature below 55 ° C, preferably at a temperature of 15 ° C - 35 ° C, more vorzugswei- se 20 ° C-25 ° C performed.
  • the Posidonia leaves used in inventive procedural ⁇ ren typically have a moisture content of at least 70% and is particularly positive in a range of 80-90%, which is überaschender-, in experiments on the production of the press juice by way of direct pressing impact compared to samples with a lower moisture content to which moisture was previously extracted by air drying and freeze-drying.
  • the pressing process leads in a first step to a disruption of the cells and escape of the air from the hollows, before in a second step, a compression takes place under release of the press juice which leads to ei ⁇ nem pressure drop and reduction of the pore volume in the pressed plant material before subsequently ⁇ °d adjust a constant pressing pressure in the last step after delivery of the press juice and pomace plant material (also known as "presscake") is ver ⁇ remains.
  • the core feature of this direct pressing in the sense of the present invention is in particular that no organic ⁇ rule solvents are needed, so
  • the press juice obtained by the direct pressing is then subsequently purified according to the invention by separating off the desired phenols, in particular the cichoric acid, and may optionally be dehydrated beforehand
  • the separation and purification steps following the pressing are familiar to the person skilled in the art and include, for example, sedimentation, filtration and centrifugation.
  • the invention has further recognized that in a mechanical pressing of the Posidonia leaves according to the inventive method at a pressure of 180-250 bar particularly much press juice can win.
  • comparative tests were carried out to manual pressure and found that with a correspondingly high pressure applying hydraulic press compared to the manual pressing a yield improvement to 464%, ie a multiple compared to the hand pressing, is achieved.
  • Posidonia is a saltwater plant, so that their ab ⁇ loomen or harvested leaves are inevitably loaded with salt and when shooting from the beach usually with sand and smaller stones.
  • These deposits can preferably be removed before the mechanical pressing in the process according to the invention with a freshwater purification of the leaves, which can be followed, if necessary, by treatment of the leaves with water vapor for enzyme inactivation in the foliage leaves.
  • This enzyme inactivation with water vapor preferably takes place with overpressure, ie at correspondingly mild temperatures, in order to avoid degradation of the temperature-sensitive phenols and in particular of the cichoric acid.
  • the Posidonia leaves remain largely green, while a brown color of the leaves are an indicator of the onset of enzymatic degradation of the polyphenols to be recovered and in particular the cichoric acid.
  • the compressed juice obtained in the process according to the invention and the polyphenols, in particular the cichoric acid can be used analogously to the extracts conventionally obtained from Echinacea plants.
  • a base or additive in a Kosme ⁇ tik.
  • a cosmetic method preferably in a natural cosmetic product or in a naturkos ⁇ metic method a.
  • Food or dietary supplements or as a base or additive in a food or food supplement ⁇ medium into consideration.
  • a medicament preferably selected for use in a kla ⁇ animals (for example, in a human or livestock) in enhancing the immune system activity, for pain reduction, as anti-reduction agents, including cardiovascular inflammation, pain relief agents, antidepressants or for treating a disease of the group consisting of a bacterial infection, viral disease, including HIV, diabetes, Alzheimer's, cancer, skin diseases, including atopic dermatitis.
  • CiGrsoriensä rstjeiialt - -
  • TSSG dry matter content is determined by drying at 105 ° C to constant weight. The batch under investigation had a dry matter content of 21%.
  • the posidonia cichoric acid content determined in the present study is at the level of the highest Ec nacea values.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Emergency Medicine (AREA)
  • Diabetes (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biotechnology (AREA)
  • Birds (AREA)
  • Microbiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Food Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Nutrition Science (AREA)
  • Rheumatology (AREA)
  • Polymers & Plastics (AREA)

Abstract

L'invention concerne un procédé d'extraction de polyphénols, de préférence d'acide chicorique à partir de jus de pression de plantes du genre Posidonia, ainsi que différentes utilisations de ces substances de base dans le domaine des produits alimentaires, des compléments alimentaires, des produits pharmaceutiques et des produits cosmétiques.
PCT/DE2018/100371 2017-04-24 2018-04-19 Extraction et utilisation de polyphénols, en particulier d'acide chicorique, à partir de plantes du genre posidonia WO2018196918A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE112018002135.1T DE112018002135A5 (de) 2017-04-24 2018-04-19 Gewinnung und Nutzung von Polyphenolen, insbesondere Cichoriensäure, aus Pflanzen der Gattung Posidonia

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102017206827.2A DE102017206827A1 (de) 2017-04-24 2017-04-24 Gewinnung und Nutzung von Polyphenolen, insbesondere Cichoriensäure, aus Pflanzen der Gattung Posidonia
DE102017206827.2 2017-04-24

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WO2018196918A1 true WO2018196918A1 (fr) 2018-11-01

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WO (1) WO2018196918A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115886126A (zh) * 2022-10-17 2023-04-04 青海大学 基于高原环境的菊苣酸饲料添加剂、制备方法及应用

Citations (6)

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WO2001022977A2 (fr) 1999-09-30 2001-04-05 Factors R & D Technologies Ltd. Supplement a base d'echinacea et son procede de fabrication
US20110015140A1 (en) * 2006-08-18 2011-01-20 Centre National De La Recherche Scientifique (Cnrs) Anti-diabetes composition containing chicoric acid and/or one of the metabolites thereof
WO2013055315A1 (fr) * 2011-10-11 2013-04-18 Elc Management Llc Procédé et compositions de traitement de la peau
EP1944423B1 (fr) 2007-01-11 2014-06-25 Richard Meier Matériau isolant à base de matières premières renouvelables
CN105230851B (zh) * 2015-11-18 2016-09-21 福建省幸福生物科技有限公司 一种增强免疫力的参茶饮料及其制备方法
CN105963197A (zh) * 2016-06-18 2016-09-28 广州丹奇日用化工厂有限公司 含菊苣酸的控油清痘霜及其制备方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001022977A2 (fr) 1999-09-30 2001-04-05 Factors R & D Technologies Ltd. Supplement a base d'echinacea et son procede de fabrication
US20110015140A1 (en) * 2006-08-18 2011-01-20 Centre National De La Recherche Scientifique (Cnrs) Anti-diabetes composition containing chicoric acid and/or one of the metabolites thereof
EP1944423B1 (fr) 2007-01-11 2014-06-25 Richard Meier Matériau isolant à base de matières premières renouvelables
WO2013055315A1 (fr) * 2011-10-11 2013-04-18 Elc Management Llc Procédé et compositions de traitement de la peau
CN105230851B (zh) * 2015-11-18 2016-09-21 福建省幸福生物科技有限公司 一种增强免疫力的参茶饮料及其制备方法
CN105963197A (zh) * 2016-06-18 2016-09-28 广州丹奇日用化工厂有限公司 含菊苣酸的控油清痘霜及其制备方法

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Title
ANON: "Posidonia Oceanica L'erba di Poseidon", 6 April 2016 (2016-04-06), XP055324192, Retrieved from the Internet <URL:http://web.archive.org/web/20160425191838/http://www.maressentia.it/posidonia-oceanica/> [retrieved on 20161129] *
GRIGNON-DUBOIS MICHELINE ET AL: "Phenolic fingerprint of the seagrass Posidonia oceanica from four locations in the Mediterranean Sea: first evidence for the large predominance of chicoric acid", BOTANICA MARINA, vol. 58, no. 5, October 2015 (2015-10-01), pages 379 - 391, XP002783404 *
MANCEK B ET AL: "Determination of cichoric acid content in dried press juice of purple coneflower (Echinacea purpurea) with capillary electrophoresis", TALANTA, ELSEVIER, AMSTERDAM, NL, vol. 66, no. 5, 15 June 2005 (2005-06-15), pages 1094 - 1097, XP027860052, ISSN: 0039-9140, [retrieved on 20050615] *
MEHMET ZEKI HAZNEDAROGLU ET AL: "HPLC Determination of Chicoric Acid in Leaves of Posidonia oceanica .", PHARMACEUTICAL BIOLOGY, vol. 45, no. 10, 7 January 2007 (2007-01-07), NL, pages 745 - 748, XP055324275, ISSN: 1388-0209, DOI: 10.1080/13880200701585717 *
QU, LUPING ET AL.: "Patterns of Variation in Alkamides and Cichoric Acid in Roots and Aboveground Parts of Echinacea purpurea (L.) Moench", HORT SCIENCE, vol. 40, no. 5, 2005, pages 1239 - 1242

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115886126A (zh) * 2022-10-17 2023-04-04 青海大学 基于高原环境的菊苣酸饲料添加剂、制备方法及应用

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