WO2018194360A1 - Composition d'amélioration de la peau - Google Patents

Composition d'amélioration de la peau Download PDF

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Publication number
WO2018194360A1
WO2018194360A1 PCT/KR2018/004478 KR2018004478W WO2018194360A1 WO 2018194360 A1 WO2018194360 A1 WO 2018194360A1 KR 2018004478 W KR2018004478 W KR 2018004478W WO 2018194360 A1 WO2018194360 A1 WO 2018194360A1
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WO
WIPO (PCT)
Prior art keywords
extract
cosmetic composition
skin
catechin
present
Prior art date
Application number
PCT/KR2018/004478
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English (en)
Korean (ko)
Inventor
우진석
김대희
서원민
강선엽
양지영
강태호
정혜빈
Original Assignee
주식회사 진켐
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication of WO2018194360A1 publication Critical patent/WO2018194360A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin

Definitions

  • the present invention relates to a composition for improving skin having no side effects and exhibiting excellent efficacy in skin whitening and skin moisturizing effects.
  • This skin barrier function may be a protection function against various stimuli (chemicals, air pollutants, dry environment, ultraviolet rays, etc.) from the outside and protection against excessive dissipation of moisture through the skin. It can only maintain its function when the stratum corneum composed of cells is normally formed.
  • the outermost stratum corneum (horney layer) of the epidermis is formed from keratinocytes and is composed of the differentiated keratinocytes and the surrounding lipid layer.
  • Keratinocytes are characteristic cells whose basal cells, which continuously proliferate in the epidermal layer, undergo morphological and functional changes in stages and rise to the surface of the skin. Exfoliated and new keratinocytes take over their function. This repetitive sequence of changes is called “epidermal differentiation” or “keratinization.”
  • keratinocytes form a natural moisturizing factor (NMF) and intercellular fats (ceramides, cholesterol, fatty acids, etc.) to form a stratum corneum, which makes the stratum corneum firm and flexible and thus the skin barrier (skin). function as a barrier.
  • NMF moisturizing factor
  • intercellular fats ceramides, cholesterol, fatty acids, etc.
  • the stratum corneum can easily lose its function due to excessive face washing, lifestyle factors such as bathing, environmental factors such as dry air pollutants, and endogenous diseases such as atopic or aged skin. Recently, due to a variety of factors, more and more skin complaints and dry skin complaints are increasing in recent years.
  • the moisturizing agent it is common to use a lipid component such as ceramide and a substance capable of increasing water retention in the stratum corneum such as essential fatty acids and lipid complexes.
  • Human skin color is also determined by several factors, including the activity of melanocytes (melanocytes) that make melanin pigments, the distribution of blood vessels, the thickness of the skin, and the presence or absence of pigments in and outside the body, such as carotenoids or bilirubin.
  • melanocytes melanocytes
  • a black pigment called melanin produced by the action of various enzymes such as tyrosinase in melanocytes is the most important factor.
  • the formation of melanin pigment is influenced by genetic factors, physiological factors related to hormone secretion, stress, and environmental factors such as ultraviolet irradiation. Melanin is present in the skin and plays an important role in protecting the body from ultraviolet rays.
  • the present applicant is not only safe for the living body, but also the active ingredient is stable in the formulation, and above all, it improves the existing skin, that is, promotes the function of keratinocytes, strengthens the skin barrier function, and effectively produces the melanin pigment of melanocytes. Intensified research on inhibitors. As a result, when using a mixture of glyceryl glucoside and catechin was confirmed to exhibit an improved synergistic effect on the desired effect, the present invention was completed.
  • the present invention provides a cosmetic composition comprising glyceryl glucoside and catechin as an active ingredient.
  • composition according to an aspect of the present invention may be a cosmetic composition for skin whitening.
  • composition according to an aspect of the present invention may be a cosmetic composition for moisturizing the skin.
  • the present invention has excellent effects and effects on skin whitening and skin moisturizing effect. These effects and effects correspond to a remarkable synergistic effect compared to the case where each single ingredient is an active ingredient.
  • composition for improving skin according to the present invention will be described below, unless otherwise defined in the technical terms and scientific terms used at this time, has a meaning commonly understood by those of ordinary skill in the art In the following description, descriptions of well-known functions and configurations that may unnecessarily obscure the subject matter of the present invention will be omitted.
  • the term 'skin improvement' refers to smoothing the skin surface, giving skin moisturizing and glossiness, and improving skin tone by suppressing or inhibiting roughening of the skin surface under the influence of aging, stress, and the like. In addition, any action that improves or beneficially changes the skin condition.
  • moisture refers to inhibiting or suppressing the decrease in moisture of the skin or increasing the moisture content of the skin to smooth the surface of the skin and impart gloss.
  • 'whitening' refers to not only brightening the skin tone, but also improving skin hyperpigmentation such as blemishes and freckles due to ultraviolet rays, hormones or heredity.
  • 'Camellia sinensis' used in the present invention, is an evergreen shrub of the Camellia family and is generally referred to as green tea, which is processed without fermenting its shoots or leaves during the manufacturing process. It is said that the green tea has been drank from China's Sinongsi in 2700 BC, and in Korea, it is said that tea was drunk from the time of King Silla Deok. Green tea also contains catechins, flavonoids, theanine, GABA, caffeine, caffeine, tannins, and other vitamins. It is known to have various effects such as lowering and enhancing immune function. In particular, catechin is a major functional component of green tea, and is known to exhibit various pharmacological effects ranging from anti-oxidation, anti-cancer, antibacterial, and suppression of heart disease.
  • the term 'extract' used in the present invention refers to a conventional method known in the art by adding an extraction solvent to at least one selected from leaves, flowers, stems, branches, roots, outposts, bark and fruits of plants. Is extracted accordingly. That is, using a conventional solvent under the conditions of the normal temperature and pressure, cold extraction, ultrasonic extraction, reflux cooling extraction, hot water extraction, room temperature extraction, warm extraction, supercritical extraction may be extracted, but is not limited thereto. It doesn't happen.
  • the extraction solvent is not limited thereto, but water, anhydrous or hydrous lower alcohol having 1 to 7 carbon atoms, hexane, chloroform, ethyl ether, acetone, ethyl acetate, butyl acetate, 1,3-butylene glycol, 1,
  • 2-propylene glycol, 1,3-propylene glycol, and the like can be used, preferably lower alcohols selected from methanol, ethanol, propanol and butanol, water and the like.
  • the extract extracted by the extraction solvent is a concept that includes all the extracts, fractions, purified products, their dilutions, concentrates or dried products obtained in each step of the fraction or purification, in some cases, lyophilization, vacuum drying Hot air drying, spray drying, reduced pressure drying, foam drying, high frequency drying, infrared drying and the like can be dried using a method, and may further have a process of grinding the dried extract.
  • the extract is characterized in that it has a liquid, concentrated solid phase and freeze-dried powder form, as the filter has an additional process, such as drying and grinding if desired.
  • lipophilic nonionic surfactant and “hydrophilic nonionic surfactant” may be classified and defined by HLB (hydrophilic-lipophilic-balance) value unless otherwise defined.
  • the lipophilic nonionic surfactant may have an HLB value of 0 to 10, and preferably may have an HLB value of 2 to 7.
  • the hydrophilic nonionic surfactant may have a HLB value of 10 to 20, and preferably may have a HLB value of 13 to 18.
  • the term 'comprising as an active ingredient' means a cosmetic composition, which may mean to include an effective amount of the degree that can exhibit the efficacy and effect according to the present invention.
  • Glyceryl glucoside is a substance in which glycerol and glucose are combined and is known to exert a whitening effect by inhibiting melanin production or inhibiting activity of the enzyme tyrosinase. Recently, the increase in aquaporin-3 expression by the glyceryl glucoside has been found, attracting attention as a moisturizing component.
  • the present applicant combines the glyceryl glucoside with an additional active ingredient, thereby imparting not only an increase in the whitening and moisturizing effect of the above-mentioned glyceryl glucoside, but also an additional function, thereby researching a cosmetic composition having new complex functionalities. While deepening, the present invention was completed by confirming that the above-described effects could be realized by combination with a catechin which is a specific polyphenol.
  • catechin Since catechin has a lot of hydroxy groups (-OH) in its chemical structure, it has a property of easily binding to various substances, and effects such as antioxidant, anticancer, cardiovascular disease prevention, and detoxification are known. However, due to the above-described chemical structure, long-term storage at room temperature is known to cause oxidation and discoloration (eg, browning). When used in cosmetic compositions, the amount of use is limited or the use of transparent or white cosmetic compositions has been limited.
  • the cosmetic composition according to the present invention in particular, the cosmetic composition comprising glyceryl glucoside and catechin as an active ingredient can effectively suppress the above problems of catechin, as well as excellent skin safety, efficacy of various embodiments Complex effects on the biological mechanisms in the skin, leading to excellent skin improvement.
  • the kind of the catechin of the cosmetic composition according to an embodiment of the present invention is not limited, but preferably includes one or two or more mixtures selected from epigallocatechin gallate, gallocatechin gallate, epicatechin, and catechin gallate. Can be.
  • the cosmetic composition according to an aspect of the present invention may be one containing glyceryl glucosite and green tea extract including the catechin as an active ingredient.
  • the green tea extract of the cosmetic composition according to an aspect of the present invention is (-) catechin, (+) catechin as well as epigallocatechin gallate, gallocatechin gallate, epicatechin gallate, catechin gallate, epigalo catechin, Catechins of various embodiments, such as gallo catechin, (-) epicatechin, (+) epicatechin.
  • the cosmetic composition according to an aspect of the present invention in the case of including a green tea extract containing catechins of various embodiments at the same time, as well as effectively solve the problems of the above-described catechins with a stronger interaction with glyceryl glucoside,
  • the skin whitening effect and the skin moisturizing effect are shown to be remarkable in the desired effect and effect in the present invention, which is preferred in the present invention.
  • the catechin derived from the green tea extract is defined as green tea catechin.
  • the green tea extract in the present invention extracted the green tea by a variety of methods (for example, cold extraction, ultrasonic extraction, reflux cooling extraction, hot water extraction, room temperature extraction, warm extraction, supercritical extraction, etc.), and filtered It means having a liquid, concentrated solid phase or lyophilized powder form after the dry grinding process.
  • the amount of the glyceryl glucoside and catechin used in the cosmetic composition according to an embodiment of the present invention is not limited, but in terms of maximizing the above-described effects and effects, the catechin is 10 to 200 based on 100 parts by weight of glyceryl glucoside. It may be included in the weight range, preferably catechin in the range of 30 to 150 parts by weight, more preferably catechin in the range of 50 to 120 parts by weight.
  • the cosmetic composition according to an aspect of the present invention may further include a polyhydric alcohol.
  • the polyhydric alcohol is not limited as long as it is a conventional moisturizing component, non-limiting examples thereof glycerin, 1,3-propanediol, 1,3-butanediol, 1,5-pentanediol, 1,2-hexanediol , 1,8-octanediol and 1,10-decanediol, sorbitol, diglycerin, erythritol, pentaerythritol, polybutyleneglycol-10, polyglycerin-3, polyglycerine-4, polyglycerine-6, polyglycerine -10, polyglycerin-20, polyglycerin-40, inositol, maltitol, met, mannitol, mannose, lactitol, lactose, dihydroxypropyl PG-glucoside, fruct
  • the cosmetic composition according to an aspect of the present invention increases formulation stability with excellent compatibility, provides a moisturizing effect continuously by synergy of improved moisturizing power, and may occur during long-term storage in a cosmetic composition including catechin.
  • glycerin, 1,2-hexanediol or a mixture thereof may be preferably used, and a mixture further including the above-mentioned polyhydric alcohol may be used. to be.
  • Cosmetic composition according to an aspect of the present invention may be included in the range of 0.1 to 30% by weight, based on the total weight of the polyhydric alcohol, preferably 0.1 to 20% by weight, more preferably 0.5 to 10% by weight. However, it is not limited thereto.
  • the cosmetic composition according to an aspect of the present invention may further include a nonionic surfactant.
  • the nonionic surfactant is not limited as long as it is commonly used, but may include a lipophilic nonionic surfactant, a hydrophilic nonionic surfactant or both thereof.
  • the cosmetic composition according to an aspect of the present invention further improves the stability of the formulation by further including the nonionic surfactant, and may be precipitated from catechin and other polyphenols (eg, tannin, etc.) contained in the catechin or green tea extract. Can effectively suppress the problem.
  • the nonionic surfactant may be precipitated from catechin and other polyphenols (eg, tannin, etc.) contained in the catechin or green tea extract. Can effectively suppress the problem.
  • the nonionic surfactant may have a hydroxyl value (Hydroxy value; measured using OHV, ISO 4629-1978, mg KOH / g) of 250 or less, and preferably 200 or less. It may be, and more preferably may be 50 or more and 150 or less.
  • Non-limiting examples of nonionic surfactants satisfying the above conditions include polysorbate, polyoxyethylene-polyoxypropylene, glycerin fatty acid ester, polyoxyethylene-glycerine fatty acid ester, and the like.
  • the polysorbate nonionic surfactant may be selected from polysorbate 20, polysorbate 40, polysorbate 60, polysorbate 65, polysorbate 80, polysorbate 85, and the like.
  • the total amount of the nonionic surfactant may be included in the range of 0.1 to 10% by weight, based on the total weight of the composition, preferably 0.5 to 10% by weight, more preferably 0.5 to 8% by weight. It is not limited.
  • Cosmetic composition according to an aspect of the present invention may be for skin whitening.
  • melanin production including as a single component in the expression inhibitory effect of proteins such as tyrosinase (Tyrosinase), Trp-1, and Trp-2, MITF that are involved in melanin biosynthesis It shows a remarkably improved effect compared to the case, especially in inhibiting melanin production.
  • the cosmetic composition according to an aspect of the present invention may further include a known whitening ingredient, in order to maximize the skin lightening effect.
  • the whitening component is not generally limited as long as it shows a whitening effect, but as a non-limiting example, mulberry extract, oil-soluble licorice extract, rice bran extract, brown rice extract, ginseng extract, red ginseng extract, black ginseng extract, wild ginseng culture extract, root root extract , Triticale Extract, Agrimoni Extract, Indochona Root Extract, Jeju Sorrel Extract, Red Ginseng Extract, Euiin Extract, White Extract, Wheat Germ Extract, Western Plum Extract, Arbutin, Ethyl Ascorbyl Ether, Ascorbyl Glucoside, Magnesium Ascorbyl Phosphate , Ascorbyl triisopalmitate, niacinamide, alpha-bisabolol, acetyltyrosine, fullerine, orrizol, methoxypiji-7 ascorbic acid, dihydroxymethoxychalcone, acetylphytosphingosine, polydatin, dios
  • Cosmetic composition according to an aspect of the present invention may be for skin moisturizing.
  • glyceryl glucoside or catechin alone when used, it shows a significantly improved skin moisturizing effect and simultaneously provides the above-mentioned effects and effects.
  • the biological mechanisms in the skin may be affected in combination, and the effect of brightening the color and skin tone as well as skin moisturization may be exhibited.
  • the cosmetic composition according to an aspect of the present invention may further include additional moisturizing ingredients that can help maintain the barrier function caused by external stimulation by promoting the growth and differentiation of the epidermis as well as skin moisturizing. to be.
  • the moisturizing component is not limited, but is not limited to isoflavones selected from zenithine, dydazine, glycithin, genistein, dyedzein, and glycidane; And compound K; Etc. can be mentioned.
  • Cosmetic compositions according to one aspect of the invention may be prepared in an emulsion formulation or a solubilized formulation.
  • the cosmetic composition of the emulsified formulations may include nutrient cosmetics, essences, eye creams, nutrition creams, massage creams, cleansing creams, cleansing foams, etc., and the cosmetic composition of the solubilized formulations, supple cosmetics, astringent cosmetics, cleansing Water, and the like. It is, of course, formulated in the form of a pack, spray or cone stick, and can be prepared in the form of adjuvants which can be applied topically or systemically as commonly used in the field of dermatology.
  • the cosmetic composition according to an aspect of the present invention may be included in the formulation, the cosmetic composition comprising the glyceryl glucoside and catechin as an active ingredient, 0.001 to 50% by weight, preferably 0.01 to 30.0% by weight, May be included in an amount of 0.01 to 20.0 wt%.
  • each cosmetic composition was tested to 10 ⁇ g / ml, 20 ⁇ g / ml, and arbutin, a positive control, was added to the medium to 200 ⁇ g / ml and treated to B-16 melanoma cells, respectively. And incubated for 3 days.
  • the melanin amount was measured by absorbance per unit cell count (10 6 cells), and the melanin production relative to the negative control (no addition) was calculated as the inhibition rate (%) (see Table 2).
  • the test site was defined as a rectangle of 4 x 3 cm 2 on the left and right inner side of the lower chest, and the skin surface capacitance was measured three times using a coneometer (Corneometer, CM825). 24 ⁇ L (2 mg / cm 2) of the samples of Examples 1 to 3 and Comparative Examples 1 and 4 were applied to the test site.
  • NTdi nth measured value where no sample is applied
  • NTd0 before measurement of the area where the sample is not applied
  • Formulation stability is circulated once daily at room temperature (20 ⁇ 2 °C), cold and thermostatic bath (4 ⁇ 2 °C), high temperature bath (45 ⁇ 2 °C) and cycle chamber (Freeze-Thaw Chamber, -20 °C to 45 °C). ), And discoloration and phase separation of each sample at a weekly interval were visually observed (see Table 5).
  • the cosmetic composition according to the present invention not only shows a markedly improved melanin production inhibitory ability compared to the negative control, but also shows a superior melanin production inhibitory activity at a lower test concentration than when arbutin is known as a whitening ingredient. It can be seen.
  • the efficacy and effect of the cosmetic composition according to the present invention described above corresponds to a surprising synergistic effect compared to the cosmetic composition comprising EGCG or glyceryl glucoside alone. That is, the cosmetic composition according to the present invention can be expected not only to improve the skin moisturizing effect, but also to improve the skin brightness from the skin texture.
  • the cosmetic composition according to the present invention exhibits a lower IC 50 value than when vitamin C is known as a conventional antioxidant component.
  • the application of catechin alone shows more significant free radical scavenging ability.
  • the cosmetic composition according to the present invention exhibits excellent activity in the above-described effects, especially as it includes catechins derived from green tea extract. This is expected to be a synergistic effect by active ingredients such as green tea saponin as well as various forms of catechins derived from green tea extracts.
  • the cosmetic composition according to the present invention shows a significantly improved short-term moisturizing effect compared to the cosmetic composition comprising EGCG or glyceryl glucoside alone. Furthermore, it can be seen that the addition of glycerin, also known as a moisturizing component, can exhibit a synergistic effect of up to 106.5% or more, as well as a synergistic effect of up to 113.9% or more by further including a predetermined nonionic surfactant.
  • the cosmetic composition according to the present invention is confirmed that the formulation remains stable even after a long time without limiting the temperature and does not cause discoloration of the formulation that can be caused by catechin and the like. can do.
  • discoloration was observed in the case of the comparative example as well as the formulation instability of the cosmetic composition.
  • the cosmetic composition according to the present invention effectively suppresses the melanin synthesis of the skin to exhibit a whitening effect, improves skin moisturizing effect due to the strengthening of the skin barrier function, and shows an excellent skin texture improvement effect, in various aspects of the cosmetic composition It is expected to be applied to provide complex functional cosmetics.

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Abstract

La présente invention concerne une composition d'amélioration de la peau, la composition selon la présente invention présentant des effets synergiques et aucun effet indésirable dans le renforcement de la fonction de barrière cutanée, l'inhibition efficace de la génération de mélanine, et l'amélioration du teint et de la carnation, permettant ainsi une utilisation efficace en tant que composition cosmétique qui peut nettement améliorer la peau.
PCT/KR2018/004478 2017-04-19 2018-04-18 Composition d'amélioration de la peau WO2018194360A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020170050220A KR101993699B1 (ko) 2017-04-19 2017-04-19 피부 개선용 조성물
KR10-2017-0050220 2017-04-19

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WO2018194360A1 true WO2018194360A1 (fr) 2018-10-25

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CN113081884A (zh) * 2021-04-26 2021-07-09 北京中医药大学 一种抗黑色素组合物、制备方法及应用
CN115252466A (zh) * 2022-08-22 2022-11-01 青岛中科蓝智生物科技发展有限公司 一种多糖类及其衍生物在祛斑美白产品中的应用
CN115444772A (zh) * 2022-10-26 2022-12-09 广州艾卓生物科技股份有限公司 一种保湿美白组合物及其在射频美容和医美护肤中的应用
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