WO2018194359A1 - Composition améliorant la peau - Google Patents

Composition améliorant la peau Download PDF

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Publication number
WO2018194359A1
WO2018194359A1 PCT/KR2018/004477 KR2018004477W WO2018194359A1 WO 2018194359 A1 WO2018194359 A1 WO 2018194359A1 KR 2018004477 W KR2018004477 W KR 2018004477W WO 2018194359 A1 WO2018194359 A1 WO 2018194359A1
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Prior art keywords
skin
cosmetic composition
present
ginseng
ginsenoside
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PCT/KR2018/004477
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English (en)
Korean (ko)
Inventor
우진석
김대희
서원민
강선엽
양지영
강태호
정혜빈
Original Assignee
주식회사 진켐
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Publication of WO2018194359A1 publication Critical patent/WO2018194359A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Definitions

  • the present invention has no side effects, and relates to a composition for improving skin having excellent effects on skin regeneration, skin wrinkle improvement, and skin moisturizing effect.
  • cyclooxygenase-2 Cox-2, cyclooxygenase
  • MMP matrix metalloproteinase
  • NO nitric oxide
  • the collagen is present in the extracellular epilepsy as a major substrate protein produced in the fibroblasts of the skin, and important functions include the mechanical strength of the skin, the resistance of connective tissues and the adhesion of tissues, the support of cell adhesion, cell division and differentiation Induction of growth or wound healing) is known.
  • This collagen is reduced by the above-mentioned internal and external factors, which are known to be closely related to wrinkle formation of the skin.
  • extensive research on skin aging has revealed an important function of collagen in skin.
  • the epidermis located at the outermost part of the skin performs protection against various physical, chemical and mechanical stimuli from the outside and prevents excessive release of moisture through the skin.
  • This protective function is possible by the normal formation and maintenance of the stratum corneum consisting of keratinocytes.
  • the keratinocytes are cells formed by continually proliferating in the stratum basale, while the basal cells move through the stratum corneum, undergoing morphological and functional changes in stages. Keratinocytes are dislodged from the skin, and new keratinocytes from the epidermal substratum repeat the process of epidermis differentiation or keratinization, replacing their function.
  • keratinocytes produce natural moisturizing factor (NMF) and intercellular lipids such as ceramides, cholesterol, and fatty acids, and the stratum corneum acts as a barrier to the outside, resulting in a skin barrier. It will function as.
  • NMF natural moisturizing factor
  • Atopic dermatitis is also an example of dry skin, more fundamentally due to abnormal skin barrier function.
  • a lot of researches have been conducted to supply moisture from the outside or minimize the loss of water from the body, focusing on maintaining proper moisture in the skin.
  • Moisturizers such as ceramide) or derivatives thereof have been developed and used in the pharmaceutical or cosmetic field.
  • the use of such moisturizers are mostly temporary relief of symptoms rather than fundamental treatment, and do not show sufficient effects on the treatment of dry skin and abnormal skin barrier function including atopic dermatitis. Therefore, it is urgent to develop a material that fundamentally regenerates damaged skin barriers.
  • the present applicant has intensified the research on ingredients that are safe for the living body and the active ingredients are stable in the formulation, and above all, have a significant improvement effect compared to the active ingredients for improving the existing skin.
  • the combination of ginsenosides and glyceryl glucosides which have excellent effects on anti-aging, promotes transepidermal absorption of ginsenosides, thereby doubling their efficacy and significantly improving skin moisturizing effects. Confirmed that can be given at the same time, to complete the present invention.
  • An object of the present invention is to cause a skin side effect, to maximize the skin regeneration, skin wrinkle improvement and skin moisturizing effect, to provide a skin improvement composition that can effectively suppress and improve skin aging.
  • Still another object of the present invention is to provide a composition for improving skin that can maximize skin penetration by promoting transdermal absorption of ginsenoside, which is a water-soluble active ingredient.
  • the present invention provides a cosmetic composition comprising glyceryl glucoside and ginsenoside as an active ingredient.
  • composition according to an aspect of the present invention may be a cosmetic composition for improving skin wrinkles.
  • composition according to an aspect of the present invention may be a cosmetic composition for moisturizing the skin.
  • the present invention has excellent effects and effects on skin regeneration, skin wrinkle improvement, and skin moisturizing effect. These effects and effects correspond to a significant synergistic effect compared to the case where each single ingredient is an active ingredient.
  • each of the active ingredients obtained from the components derived from the natural combination does not cause safety problems such as irritation or redness of the skin, but also significantly improves the transdermal absorption of hydrophilic ginsenosides, It is expected to be applicable to the complex functional cosmetic composition of the formulation.
  • composition for improving skin according to the present invention will be described below, unless otherwise defined in the technical terms and scientific terms used at this time, has a meaning commonly understood by those of ordinary skill in the art In the following description, descriptions of well-known functions and configurations that may unnecessarily obscure the subject matter of the present invention will be omitted.
  • the term 'skin improvement' refers to smoothing the skin surface, giving skin moisturizing and glossiness, and improving skin tone by suppressing or inhibiting roughening of the skin surface under the influence of aging, stress, and the like. In addition, it refers to any action that improves or beneficially changes the skin condition by improving skin wrinkles and enhancing elasticity.
  • 'antioxidation' refers to oxidation of cells by highly reactive free radicals or reactive oxygen species (ROS) according to oxidative stress caused by intracellular metabolism or ultraviolet rays. It refers to inhibiting, including the removal of free radicals or reactive oxygen species, thereby reducing damage to the cells.
  • ROS reactive oxygen species
  • 'wrinkle improvement' refers to inhibiting or inhibiting wrinkles generated on the skin or alleviating wrinkles already generated.
  • the "elasticity enhancement” refers to the increase in elasticity to the skin, to inhibit or inhibit the loss of skin elasticity, or to alleviate the already reduced elasticity.
  • moisture refers to inhibiting or suppressing the decrease in moisture of the skin or increasing the moisture content of the skin to smooth the surface of the skin and impart gloss.
  • 'ginseng Panax ginseng CA Meyer
  • ginseng a plant belonging to the genus Ogapiaceae ginseng, and is known to have pharmacological activities such as anticancer, anti-aging, antidiabetic, antistress and neuroprotective effects, and a cosmetic composition. It is known to have wrinkle improvement and whitening efficacy.
  • Ginseng in the present invention can be used without limitation in the kind and annual root, can be used both ginseng dried or not dried.
  • ginseng in the present invention can be used without limitation to the site, specifically, ginseng root, ginseng flower, leaves or fruits can be used, of course, may be preferably used ginseng root.
  • 'white ginseng' means that the epidermis of ginseng is removed and dried
  • 'red ginseng black ginseng' is a process of steaming several times and dried several times under warm conditions using ginseng (repeatedly Steamed and dried), and means processed ginseng that has undergone a manufacturing process.
  • They increase the content of the active ingredient including ginsenosides during the above-described process, and include nitrogen-containing components, polyacetylene-based compounds, flavonoids, vitamins (eg, vitamin B group), enzymes, organic acids and A high amount of amino acids and the like is preferred in the present invention, but is not limited thereto.
  • the term 'extract' used in the present invention is extracted according to a conventional method known in the art by adding an extraction solvent to at least one selected from the leaves, flowers, stems, branches, roots, outposts and fruits of plants. . That is, using a conventional solvent under the conditions of the normal temperature and pressure, cold extraction, ultrasonic extraction, reflux cooling extraction, hot water extraction, room temperature extraction, warm extraction, supercritical extraction may be extracted, but is not limited thereto. It doesn't happen.
  • the extraction solvent is not limited thereto, but water, anhydrous or hydrous lower alcohol having 1 to 7 carbon atoms, hexane, chloroform, ethyl ether, acetone, ethyl acetate, butyl acetate, 1,3-butylene glycol, 1,
  • 2-propylene glycol, 1,3-propylene glycol, and the like can be used, preferably lower alcohols selected from methanol, ethanol, propanol and butanol, water and the like.
  • the extract extracted by the extraction solvent is a concept that includes all the extracts, fractions, purified products, their dilutions, concentrates or dried products obtained in each step of the fraction or purification, in some cases, lyophilization, vacuum drying Hot air drying, spray drying, reduced pressure drying, foam drying, high frequency drying, infrared drying and the like can be dried using a method, and may further have a process of grinding the dried extract.
  • the extract is characterized in that it has a liquid, concentrated solid phase and freeze-dried powder form, as the filter has an additional process, such as drying and grinding if desired.
  • lipophilic nonionic surfactant and “hydrophilic nonionic surfactant” may be classified and defined by HLB (hydrophilic-lipophilic-balance) value unless otherwise defined.
  • the lipophilic nonionic surfactant may have an HLB value of 0 to 10, and preferably may have an HLB value of 2 to 7.
  • the hydrophilic nonionic surfactant may have a HLB value of 10 to 20, and preferably may have a HLB value of 13 to 18.
  • the term 'comprising as an active ingredient' means a cosmetic composition, which may mean to include an effective amount of the degree that can exhibit the efficacy and effect according to the present invention.
  • Glyceryl glucoside is a substance in which glycerol and glucose are combined and is known to exert a whitening effect by inhibiting melanin production or inhibiting activity of the enzyme tyrosinase. Recently, the increase in aquaporin-3 expression by the glyceryl glucoside has been found, attracting attention as a moisturizing component.
  • the present applicant is intensifying the study of a cosmetic composition having a new complex functionality by combining the glyceryl glucoside and an additional active ingredient, thereby providing additional functions as well as the effect of the above-mentioned glyceryl glucoside.
  • a cosmetic composition having a new complex functionality by combining the glyceryl glucoside and an additional active ingredient, thereby providing additional functions as well as the effect of the above-mentioned glyceryl glucoside.
  • ginsenosides it was confirmed that there is synergy in the effects described above.
  • the ginsenoside is a type of saponin known as a representative active ingredient of ginseng, is known to have cancer activity and induce regeneration of cancer cells (induce cancer cells to be re-differentiated into healthy cells).
  • Heavy Rg3 is known to have a relatively strong inhibitory effect on platelet aggregation induced by collagen and the like.
  • Ginsenoside Rhl is also known to have a significant inhibitory effect on the conversion of fibrinogen to fibrin induced by thrombin.
  • ginsenosides have been found to be effective as antioxidant effects, promoting collagen production, and are widely used as cosmetic compositions for inhibiting skin aging and improving wrinkles.
  • ginsenosides are structurally hydrophilic and have the disadvantage that their effects are temporary or insignificant when applied to cosmetic compositions despite the excellent efficacy described above.
  • the cosmetic composition according to the present invention specifically the cosmetic composition comprising glyceryl glucoside and ginsenoside as an active ingredient can effectively solve the problem of the above-mentioned ginsenosides, as well as can significantly improve transdermal absorption. .
  • the cosmetic composition according to the present invention can be effectively combined with the effects and effects of various aspects on the biological mechanism in the skin, it can give an excellent skin improvement effect.
  • ginsenosides exhibiting structural hydrophilicity. This is expected due to the strong interaction of glyceryl glucoside with ginsenosides.
  • the interaction may be a hydrogen bond, an electrostatic attraction, a van der Waals bond, or the like.
  • PPD-based ginsenosides such as Rb1, Rb2, Rb3, Rc, and Rd, which are not limited, but preferably have the following structure of the cosmetic composition according to an aspect of the present invention.
  • PPT-based ginsenosides such as Rg1, Rg2, Rg3, Rg5, Rg6, Rh1, Rh2, Rh3, Rh4, Rk1 and CK.
  • the cosmetic composition according to an aspect of the present invention is glyceryl glucoside; And ginseng, red ginseng, white ginseng and black ginseng may be included alone or mixed extracts.
  • the extract extracted from the ginseng, red ginseng, white ginseng, and black ginseng includes the ginsenosides described above.
  • the single extract or mixed extract selected from ginseng, red ginseng, white ginseng and black ginseng may be a known method (for example, cold sediment extraction, ultrasonic extraction, reflux cooling extraction, hot water extraction, room temperature extraction, warm extraction, supercritical extraction, etc.). It may be to be extracted.
  • the ginseng extract is a step of extracting by heating the ginseng root in a solvent; It may be obtained by a method comprising a; and concentrated under reduced pressure the solution obtained in the step of extracting and freeze drying.
  • the solvent is not limited, but as a non-limiting example of water, C 1-7 anhydrous or hydrous lower alcohol, hexane, chloroform, ethyl ether, acetone, ethyl acetate, butyl acetate, 1,3-butylene glycol It may be one or two or more mixed solvents selected from, 1,2-propylene glycol, 1,3-propylene glycol, and the like, preferably 100wt% of water or a hydrous lower alcohol.
  • ginsenoside is based on 100 parts by weight of glyceryl glucoside. It may be included in the range of 10 to 200 parts by weight, preferably 30 to 150 parts by weight of ginsenosides, more preferably 50 to 120 parts by weight of ginsenosides.
  • the cosmetic composition according to one aspect of the present invention when a single extract or mixed extract of ginseng, red ginseng, white ginseng, and black ginseng simultaneously containing ginsenosides of various embodiments is significant, the effect and effect desired in the present invention are remarkable.
  • the present invention is preferred in the present invention.
  • the stronger interaction with glyceryl glucoside effectively solves the above-mentioned problems of ginsenosides.
  • the active ingredient deep into the skin, by allowing these active ingredients to continuously supply the effect and effect to the skin, it is possible to provide the maximum effect and effect to the aged skin.
  • the cosmetic composition according to an aspect of the present invention may further include a polyhydric alcohol.
  • the polyhydric alcohol is not limited as long as it is a conventional moisturizing component, non-limiting examples thereof glycerin, 1,3-propanediol, 1,3-butanediol, 1,5-pentanediol, 1,2-hexanediol , 1,8-octanediol and 1,10-decanediol, sorbitol, diglycerin, erythritol, pentaerythritol, polybutyleneglycol-10, polyglycerin-3, polyglycerine-4, polyglycerine-6, polyglycerine -10, polyglycerin-20, polyglycerin-40, inositol, maltitol, met, mannitol, mannose, lactitol, lactose, dihydroxypropyl PG-glucoside, fruct
  • the cosmetic composition according to an aspect of the present invention is preferably glycerin, 1,2-hexanediol or these in terms of improving formulation stability with excellent compatibility, and can continuously provide a moisturizing effect by synergy of improved moisturizing power. It is a matter of course that a mixture of may be used, in addition to the mixture further comprising the above-described polyhydric alcohol.
  • Cosmetic composition according to an aspect of the present invention may be included in the range of 0.1 to 30% by weight, based on the total weight of the polyhydric alcohol, preferably 0.1 to 20% by weight, more preferably 0.5 to 10% by weight. However, it is not limited thereto.
  • the cosmetic composition according to an aspect of the present invention may further include a nonionic surfactant. Accordingly, the cosmetic composition according to the present invention can more effectively promote the stability of the formulation and skin penetration of ginsenosides.
  • the nonionic surfactant may be used as one or two or more mixtures selected from lipophilic nonionic surfactants and hydrophilic nonionic surfactants, as well as lipophilic nonionic surfactants and hydrophilic nonionics. It is of course possible to use mixtures of surfactants.
  • the cosmetic composition according to an aspect of the present invention comprises an extract extracted from ginseng, red ginseng, white ginseng, black ginseng, etc.
  • the nonionic surfactant may have a hydroxyl value (Hydroxy value; measured using OHV, ISO 4629-1978, mg KOH / g) of 250 or less, and preferably 200 or less. It may be, and more preferably may be 50 or more and 150 or less.
  • Non-limiting examples of nonionic surfactants satisfying the above conditions include polysorbate, polyoxyethylene-polyoxypropylene, glycerin fatty acid ester, polyoxyethylene-glycerine fatty acid ester, and the like.
  • the polysorbate nonionic surfactant may be selected from polysorbate 20, polysorbate 40, polysorbate 60, polysorbate 65, polysorbate 80, polysorbate 85, and the like.
  • the total amount of the nonionic surfactant may be included in the range of 0.1 to 10% by weight, based on the total weight of the composition, preferably 0.5 to 10% by weight, more preferably 0.5 to 8% by weight. It is not limited.
  • Cosmetic composition according to an aspect of the present invention may be for skin moisturizing.
  • glyceryl glucoside or catechin alone when used, it shows a significantly improved skin moisturizing effect and simultaneously provides the above-mentioned effects and effects. That is, according to the present invention, the biological mechanisms in the skin may be complexed, and the effect of brightening the color and skin tone as well as skin moisturization may be exhibited.
  • the cosmetic composition according to an aspect of the present invention may further include additional moisturizing ingredients that can help maintain the barrier function caused by external stimulation by promoting the growth and differentiation of the epidermis as well as skin moisturizing. to be.
  • the moisturizing component is not limited, and examples thereof include, but are not limited to, isoflavones selected from genistin, dydazine, glycithin, genistein, dyedzein, and glycidane.
  • Cosmetic composition according to an aspect of the present invention can be expected to excellent effect on the inhibition and improvement of skin aging, and can be evenly applied to various cosmetics, quasi-drugs, pharmaceuticals and food formulations to provide an effect against anti-aging have.
  • the cosmetic composition according to the present invention described above may be prepared in an emulsion formulation or a solubilized formulation.
  • the cosmetic composition of the emulsified formulations may include nutrient cosmetics, essences, eye creams, nutrition creams, massage creams, cleansing creams, cleansing foams, etc., and the cosmetic composition of the solubilized formulations, supple cosmetics, astringent cosmetics, cleansing Water, and the like. It is, of course, formulated in the form of a pack, spray or cone stick, and can be prepared in the form of adjuvants which can be applied topically or systemically as commonly used in the field of dermatology.
  • the cosmetic composition according to an aspect of the present invention may include a cosmetic composition comprising the glyceryl glucoside and ginsenoside as an active ingredient in the formulation, 0.001 to 50% by weight, preferably 0.01 to 30.0% by weight, More preferably 0.01 to 20.0% by weight.
  • each of the cosmetic compositions prepared in the following Examples and Comparative Examples was subjected to three skin permeation tests using the skin of hairless mice. 48 ⁇ l of sample was injected into the skin surface of 7.5 mm in diameter, and the amount of ginsenoside permeated after 24 hours using a transdermal absorption device (Microette, Hanson Co.) was obtained by high-performance liquid chromatography. Quantitatively by graphy, it was calculated as the percent transmittance of ginsenosides (see Table 2).
  • each cosmetic composition was 10 ⁇ g / mL and 20 ⁇ g / mL, and the positive control vitamin C was added to the medium so as to be 50 ⁇ g / ml, and a negative control (no addition) was added to each of fibroblasts derived from humans ( 7 ⁇ 10 4 cells / cm 2) were added to the culture medium and incubated for 1 day, and then the culture medium was taken and measured at 450 nm using a spectrophotometer at the concentration of collagen biosynthesis at each concentration using PICP EIA Kit. At this time, the collagen biosynthesis was calculated as the increase rate (%) relative to the negative control ability (see Table 3).
  • the test site was defined as a rectangle of 4 x 3 cm 2 on the left and right inner side of the lower chest, and the skin surface capacitance was measured three times using a coneometer (Corneometer, CM825).
  • NTdi nth measured value where no sample is applied
  • NTd0 before measurement of the area where the sample is not applied
  • Formulation stability is circulated once daily at room temperature (20 ⁇ 2 °C), cold and thermostatic bath (4 ⁇ 2 °C), high temperature bath (45 ⁇ 2 °C) and cycle chamber (Freeze-Thaw Chamber, -20 °C to 45 °C). ), And discoloration and phase separation of each sample at a weekly interval were visually observed (see Table 5).
  • the cosmetic composition according to the present invention can be seen that the permeability is significantly promoted compared to the comparative example.
  • the effect thereof is doubled by further including a polyhydric alcohol and / or a nonionic surfactant.
  • the cosmetic composition according to the present invention not only shows excellent collagen synthesis ability for human-derived fibroblasts, but also superior collagen synthesis ability at a lower test concentration than that of vitamin C used as a positive control. It can be seen that.
  • the cosmetic composition according to the present invention can be excellent in the skin wrinkle improvement effect, can be expected to maximize the skin improvement effect.
  • the above-mentioned efficacy and effect of the cosmetic composition according to the present invention described above corresponds to a surprising synergistic effect compared to the cosmetic composition comprising ginsenoside or glyceryl glucoside alone.
  • the cosmetic composition according to the present invention shows a significantly improved short-term moisturizing effect compared to the cosmetic composition comprising ginsenoside or glyceryl glucoside alone.
  • glycerin also known as a moisturizing component
  • glycerin can exhibit a synergistic effect of up to 109.8% or more, as well as a synergistic effect of up to 126.5% or more by further including a predetermined nonionic surfactant.
  • the cosmetic composition according to the present invention is confirmed that the formulation remains stable even after a long time without limiting the temperature and does not cause discoloration of the formulation that can be caused by catechin and the like. can do.
  • discoloration was observed in the case of the comparative example as well as the formulation instability of the cosmetic composition.
  • the cosmetic composition according to the present invention promotes collagen synthesis of fibroblasts of the skin, promotes the proliferation of skin stem cells, promotes the regeneration of the skin, improves wrinkles, enhances elasticity, and improves the skin with a significantly improved skin moisturizing effect. It is expected to be excellent in the effect of improving the texture, and to be applied to cosmetic compositions of various embodiments to provide a composite functional cosmetic.

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Abstract

La présente invention concerne une composition améliorant la peau, la composition selon la présente invention présentant d'excellents effets synergiques avec les effets de fibroblastes dermiques pour stimuler la synthèse de collagène et de mélanine, l'élimination de radicaux libres, et l'amélioration de l'éclaircissement de la peau, de façon à permettre une utilisation efficace en tant que composition cosmétique qui peut notamment améliorer la peau sans aucun effet indésirable.
PCT/KR2018/004477 2017-04-19 2018-04-18 Composition améliorant la peau WO2018194359A1 (fr)

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EP3973974A4 (fr) * 2019-05-20 2023-05-10 CJ Cheiljedang Corporation Composition pour augmenter la biodisponibilité et favoriser l'absorption de ginsénosides dans un extrait de ginseng noir
EP4069215A4 (fr) * 2019-12-06 2024-01-17 JLABS Beauty LLC Compositions topiques contenant de l'huile de rose et du cannabidiol et procédés pour leur préparation et utilisation

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US20090130223A1 (en) * 2006-04-27 2009-05-21 Ute Breitenbach Cosmetic preparation with aquaporin stimulators and the use thereof
KR101233833B1 (ko) * 2009-09-29 2013-02-18 홍성빈 진세노사이드 알이를 함유한 피부 보습 및 주름 개선용 화장 조성물
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EP3973974A4 (fr) * 2019-05-20 2023-05-10 CJ Cheiljedang Corporation Composition pour augmenter la biodisponibilité et favoriser l'absorption de ginsénosides dans un extrait de ginseng noir
EP3973975A4 (fr) * 2019-05-20 2023-06-21 CJ Cheiljedang Corporation Composition contre le virus de la grippe, composition pour le traitement de maladies respiratoires et composition anti-âge, comprenant un extrait de ginseng noir
EP4069215A4 (fr) * 2019-12-06 2024-01-17 JLABS Beauty LLC Compositions topiques contenant de l'huile de rose et du cannabidiol et procédés pour leur préparation et utilisation

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