WO2018152758A1 - 一种抗炎乳液 - Google Patents

一种抗炎乳液 Download PDF

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WO2018152758A1
WO2018152758A1 PCT/CN2017/074704 CN2017074704W WO2018152758A1 WO 2018152758 A1 WO2018152758 A1 WO 2018152758A1 CN 2017074704 W CN2017074704 W CN 2017074704W WO 2018152758 A1 WO2018152758 A1 WO 2018152758A1
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emulsion
weight
extract
inflammatory
antibacterial
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PCT/CN2017/074704
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林学镁
陈贤鹰
陈顺章
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拉芳家化股份有限公司
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Priority to CN201780005780.0A priority patent/CN109121393B/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • the invention belongs to the field of daily chemistry, and in particular relates to an anti-inflammatory emulsion.
  • the skin is the main barrier between the body and the external environment.
  • the skin barrier function of the body can produce a variety of inflammatory skin diseases, such as acne and seborrheic dermatitis.
  • the inflammation causes the skin to be rough, red and itchy, and the skin is damaged, making it more susceptible to infection by bacteria, fungi and viruses, and aggravating inflammation. It is one of the effective means by drug treatment, and in addition, by using an antibacterial and anti-inflammatory cosmetic, a certain effect can be achieved.
  • anti-inflammatory raw materials have been used in cosmetics, among which antibacterial and anti-inflammatory materials derived from plants are favored because they are relatively mild.
  • the invention uses a plurality of plant extracts having certain antibacterial and anti-inflammatory effects: a bitter bean extract (the mycophenolate contains antibacterial, anti-inflammatory and anti-tumor effects), and an extract of purple echinacea (containing phenol) Classes, polysaccharides and plant sterols, anti-bacterial, anti-viral, anti-fungal and anti-inflammatory), sage extract (plant phenolic substances are resistant to bacterial and fungal infections), Centella asiatica extract (antibacterial, anti-inflammatory) It promotes the synthesis of fibroblasts and collagen) and the extract of Artemisia argyi, and additionally adds allantoin which has the same anti-inflammatory effect to make an emulsion to enhance the anti-inflammatory effect.
  • a bitter bean extract the mycophenolate contains antibacterial, anti-inflammatory and anti-tumor effects
  • an extract of purple echinacea containing phenol
  • polysaccharides and plant sterols polysaccharides and plant sterols, anti-
  • the extract of Sophora alopecuroides (or extract of Sophora alopecurus L.) is extracted from the medicinal plant Sophora alopecuroides of Ningxia.
  • the bitter bean has the functions of clearing away heat and detoxifying, antibacterial, anti-inflammatory, analgesic and insecticidal, while the amygdalin is the medicinal plant.
  • Active substances with antibacterial and anti-inflammatory effects studies have shown that amygdalin can reduce the pro-inflammatory factor TNF- ⁇ and increase the production of anti-inflammatory cells IL-10, which can alleviate and resist inflammation.
  • research on the extract of the medicinal plant is mostly focused on its analgesic effect and application in the field of medicine; with the limited knowledge of the author, the application of the extract in the cosmetic anti-inflammatory lotion is rarely reported.
  • An anti-inflammatory emulsion containing, in addition to the general ingredients acceptable for the emulsion,
  • An emulsifier comprising from 1.25% to 3.0% by weight of the emulsion, the emulsifier being from 0.25% to 0.5% by weight of the emulsion of sorbitan sesquioleate and from 1.0% to 2.5% by weight of the emulsion;
  • a thickener comprising from 0.8% to 1.0% by weight of the emulsion, the thickener being a combination of xanthan gum in an amount of from 0.3% to 0.5% by weight of the emulsion and hydroxyethylcellulose in an amount of 0.5% by weight of the emulsion;
  • the moisturizing component is 11.0%-20.0% by weight of the emulsion, and the moisturizing component is 3.0%-5.0% by weight of the emulsion of shea butter, 3.0%-5.0% by weight of the emulsion of myristyl myristate, and the weight of the emulsion. a combination of 3.0%-6.0% squalane, 2.0%-4.0% by weight of emulsion, of dioctyl carbonate;
  • Plant extract with anti-inflammatory properties of 8.6%-13.0% by weight of the emulsion the extract is 0.1%-1.0% of the weight of the emulsion of the extract of Sophora flavescens, 3.0%-5.0% by weight of the emulsion
  • the invention adds a plurality of plant extracts having antibacterial and anti-inflammatory effects to the formula, and comprises a bitter bean extract, and an allantoin and a plurality of moisturizing and emollient agents are added to make the emulsion moisturize. It has a certain anti-inflammatory effect and is suitable for people with skin irritation with mild inflammation.
  • Fig. 1 is a graph showing the effect of using the anti-inflammatory emulsion of the present invention and a control group.
  • the invention pays attention to selecting the antibacterial and anti-inflammatory properties of the components, and pays attention to the moisturizing effect of the emulsion.
  • the bitter bean extract, the medicinal plant extract contains a good antibacterial and anti-inflammatory effect, and is reported to reduce the pro-inflammatory factor TNF- ⁇ and increase the production of anti-inflammatory IL-10, and It is rare to use it in anti-inflammatory lotions for cosmetics.
  • the composition also adds allantoin to enhance the antibacterial and anti-inflammatory effects of the sample.
  • the plant extracts used were all extracts.
  • Example I the manufacturing steps are as follows:

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  • Life Sciences & Earth Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
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Abstract

一种抗炎乳液，以乳液总重量计，包含1.25%-3.0%的乳化剂，0.8%-1.0%的增稠剂，11.0%-20.0.0%的保湿成分，8.6-13.0%的具有抗菌、抗炎效果的植物提取物，所述植物提取物为：苦豆草提取物、紫松果菊提取物、鼠尾草提取物、艾叶提取物以及积雪草提取物。

Description

一种抗炎乳液 技术领域
本发明属于日化领域，具体涉及一种抗炎乳液。
背景技术
皮肤是机体和外界环境接触的主要屏障,机体皮肤屏障功能下降可产生多种炎症性皮肤病，如痤疮、脂溢性皮炎等。炎症的产生使皮肤粗糙、发红发痒、皮肤破损加重，使其更容易受到外界细菌、真菌和病毒的感染，加重炎症。通过药物治疗是有效的手段之一，另外，通过使用具有抗菌、抗炎的化妆品，也能达到一定的效果。
目前，已有多种抗炎原料用于化妆品中，其中，来源于植物的抗菌抗炎原料由于相对较温和而备受青睐。
本发明复合使用多种具有一定抗菌、抗炎效果的植物提取物：苦豆草提取物(所含苦豆碱具有抗菌、抗炎及抗肿瘤作用)、紫松果菊提取物(所含酚类、多糖及植物甾醇，能抗细菌、抗病毒、抗真菌和消炎)、鼠尾草提取物(所含植物酚类物质能够抵抗细菌和真菌的感染)、积雪草提取物(抗菌、消炎、促进成纤维细胞和胶原蛋白的合成)和艾叶提取物，并另外添加同样具有抗炎效果的尿囊素制成乳液，加强抗炎效果。
苦豆草提取物(或苦豆子提取物)是从宁夏药用植物苦豆子中提取，苦豆子具有清热解毒、抗菌消炎、止痛杀虫的作用，而苦豆碱则是该药用植物具有 抗菌抗炎功效的活性物质，有研究表明苦豆碱能够减少促炎性因子TNF-α以及增加抗炎细胞IL-10的产生，对炎症有缓解、抵抗作用。目前，关于该药用植物提取物的研究较多集中于其止痛功效，以及在药物领域的应用；以作者有限的知识，该提取物在化妆品抗炎乳液中的应用还少见报道。
发明内容
本发明的目的是提供一种抗炎乳液。
本发明的目的是这样实现的：
一种抗炎乳液，除含有乳液可接受的一般成份外，还含有：
占乳液重量1.25％-3.0％的乳化剂，该乳化剂为占乳液重量0.25％-0.5％的山梨坦倍半油酸酯和占乳液重量1.0％-2.5％的吐温-80的组合；
占乳液重量0.2％-0.5％的尿囊素；
占乳液重量0.8％-1.0％的增稠剂，该增稠剂为占乳液重量0.3％-0.5％的黄原胶和占乳液重量0.5％的羟乙基纤维素的组合；
占乳液重量11.0％-20.0％的保湿成份，该保湿成份为占乳液重量3.0％-5.0％的乳木果油、占乳液重量3.0％-5.0％的肉豆蔻醇肉豆蔻酸酯、占乳液重量3.0％-6.0％的角鲨烷、占乳液重量2.0％-4.0％的碳酸二辛酯的组合；
占乳液重量8.6％-13.0％的具有抗炎性能的植物提取物，该提取物为占乳液重量0.1％-1.0％的苦豆草提取物、占乳液重量3.0％-5.0％的紫松果菊提取物、占乳液重量2.5％-3.0％的鼠尾草提取物、占乳液重量0.5％-1.0％的积雪草提取物以及占乳液重量2.0％-3.0％的艾叶提取物的组合。
本发明的抗炎乳液，其特征在于组份及其含量重量百分比分别为：
Figure PCTCN2017074704-appb-000001
本发明的有益效果
本发明在配方中添加了多种具有抗菌、抗炎效果的植物提取物，包含苦豆草提取物，另外还添加了尿囊素以及多种保湿、润肤剂，使乳液在保湿的同时，具备一定的抗炎效果，适合有轻微炎症的皮肤不适者使用。
附图说明
图1为使用本发明抗炎乳液及对照组的效果比较图。
具体实施方式
下面结合实施例对本发明作进一步详述。
先对本发明组份选取的特点、注意事项作详细介绍、说明。
本发明注重选取组份的抗菌、抗炎性能，同时关注乳液的保湿效果。选用简单的润肤剂，搭配多种具有抗菌抗炎功效的植物提取物原料，如鼠尾草提取物、紫松果菊提取物、积雪草提取物以及艾叶提取物；另外，还特别添加了苦豆草提取物，该药用植物提取物所含苦豆碱具有较好的抗菌抗炎功效，据报道能够减少促炎因子TNF-α和增加抗炎细胞IL-10的产生，而且目前少见将其用于化妆品的抗炎乳液中。除了抗菌抗炎植物提取物外，该组合物还添加了尿囊素，加强样品的抗菌抗炎效果。
所用植物提取物均为提取液。
实施例I－V
Figure PCTCN2017074704-appb-000002
Figure PCTCN2017074704-appb-000003
以实施例I为例，其制作步骤如下：
1、把0.5gEDTA-2Na、0.3g柠檬酸、60.0g甘油、20.0g1,3-丙二醇、3.0g黄原胶、5.0g羟乙基纤维素、4.0g尿囊素加入到636.9g去离子水中，加热到80℃，搅拌至溶解、分散充分。
2、把2.0g羟苯甲酯、1.0g羟苯丙酯、2.5g山梨坦倍半油酸酯、10.0g吐温-80、30.0g肉豆蔻醇肉豆蔻酸酯、40.0g乳木果油、30.0g角鲨烷、40.0g碳酸二辛酯、加到油相锅中，加热到80℃，并搅拌至溶解、分散充分。
3、把油相锅中的物料加入到水相锅中，开动均质机，速度为8000rpm/min，乳化均质10min后降温。
4、降温到50℃后依次加入4g苦豆草提取物、50g紫松果菊提取物、25.0g鼠尾草提取物、5.0g积雪草提取物和30.0g艾叶提取物。
5、降温到45℃，加入0.5g香精，搅拌均匀、降至室温后真空脱气。
本发明使用效果测试
招募15名脸部皮肤有轻微炎症(轻微红肿、瘙痒)的志愿者，将其分成三组(C0、G1和G2)，每组5人；C0为对照组，不使用抗炎乳液；G1和G2分别使用抗炎乳液I和抗炎乳液V。对志愿者进行培训，包括使用时间点、周期、抗炎乳液使用量、涂抹和按摩方法。
G1和G2组志愿者自收到抗炎乳液样品开始，每天晚上23:00涂抹，按摩1min，持续涂抹两个星期；C0组不涂抹任何样品，以作对照。涂抹前和涂抹两个星期后分别由功效评价工程师进行评分，评价抗炎乳液功效(涂抹前分数为0分)。按照改善程度进行评分：0分、2分、4分、6分、8分、10分；0分没有改善，10分完全改善。
从图1可看出，没有使用抗炎乳液的C0组，两周后改善程度较低，而使用了抗炎乳液的G1组和G2组则改善较为明显。

Claims (3)

  1. 一种抗炎乳液，除含有乳液可接受的一般成份外，还含有：
    占乳液重量1.25％-3.0％的乳化剂，该乳化剂为占乳液重量0.25％-0.5％的山梨坦倍半油酸酯和占乳液重量1.0％-2.5％的吐温-80的组合；
    占乳液重量0.2％-0.5％的尿囊素；
    占乳液重量0.8％-1.0％的增稠剂，该增稠剂为占乳液重量0.3-0.5％的黄原胶和占乳液重量0.5％的羟乙基纤维素的组合；
    占乳液重量11.0％-20.0％的保湿成份，该保湿成份为占乳液重量3.0％-5.0％的乳木果油、占乳液重量3.0％-5.0％的肉豆蔻醇肉豆蔻酸酯、占乳液重量3.0％-6.0％的角鲨烷、占乳液重量2.0％-4.0％的碳酸二辛酯的组合。
  2. 根据权利要求1所述的抗炎乳液，还包含有占乳液重量8.6％-13.0％的抗炎植物提取物，该提取物为占乳液重量0.1％-1.0％的苦豆草提取物、占乳液重量3.0％-5.0％的紫松果菊提取物、占乳液重量2.5％-3.0％的鼠尾草提取物、占乳液重量0.5％-1.0％的积雪草提取物以及占乳液重量2.0％-3.0％的艾叶提取物的组合。
  3. 根据权利要求1所述的抗炎乳液，其特征在于其组份及其含量重量百分比分别为：
    Figure PCTCN2017074704-appb-100001
    Figure PCTCN2017074704-appb-100002
PCT/CN2017/074704 2017-02-24 2017-02-24 一种抗炎乳液 WO2018152758A1 (zh)

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Cited By (1)

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Publication number Priority date Publication date Assignee Title
WO2020112590A1 (en) * 2018-11-27 2020-06-04 Societe D'exploitation De Produits Pour Les Industries Chimiques Seppic Solubilised centella asiatica extract

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