WO2018135232A1 - Dispositif d'inspection de substance étrangère, procédé d'inspection de substance étrangère, et dispositif de fabrication - Google Patents

Dispositif d'inspection de substance étrangère, procédé d'inspection de substance étrangère, et dispositif de fabrication Download PDF

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Publication number
WO2018135232A1
WO2018135232A1 PCT/JP2017/045967 JP2017045967W WO2018135232A1 WO 2018135232 A1 WO2018135232 A1 WO 2018135232A1 JP 2017045967 W JP2017045967 W JP 2017045967W WO 2018135232 A1 WO2018135232 A1 WO 2018135232A1
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Prior art keywords
light
objects
foreign matter
light source
inspection apparatus
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PCT/JP2017/045967
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English (en)
Japanese (ja)
Inventor
京子 松田
裕介 榊原
真 和泉
森　豪
綿野　哲
Original Assignee
シャープ株式会社
株式会社Ｐｓ＆Ｔ
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Application filed by シャープ株式会社, 株式会社Ｐｓ＆Ｔ filed Critical シャープ株式会社
Priority to JP2018563236A priority Critical patent/JPWO2018135232A1/ja
Publication of WO2018135232A1 publication Critical patent/WO2018135232A1/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/3563—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing solids; Preparation of samples therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/85—Investigating moving fluids or granular solids

Definitions

  • the present invention relates to a foreign matter inspection apparatus and a foreign matter inspection method.
  • This application claims priority based on Japanese Patent Application No. 2017-005839, which is a Japanese patent application filed on January 17, 2017. All the descriptions described in the Japanese patent application are incorporated herein by reference.
  • the present invention relates to a foreign matter inspection apparatus and a foreign matter inspection method that are also suitable for nondestructively determining the presence or absence of foreign matter mixed inside an object, for example, the presence or absence of organic matter such as hair and insects.
  • the present invention further relates to a manufacturing apparatus.
  • Patent Document 1 JP 2013-536950 A (Patent Document 1) and JP-A-2015-219090 (Patent Document 2) may be mentioned.
  • Patent Document 1 discloses an in-line spectroscopic reader. The spectrum of light irradiated on the object is collected in a detector of the spectrometer.
  • a tablet In factory inspections, the demand for higher speeds is extremely strict in order to increase production efficiency and reduce costs. For example, a tablet generally requires an inspection speed of 300,000 per hour, and if it is slower than this, the productivity is remarkably reduced and it cannot be used for inspection.
  • the object to be inspected is strongly scattered or absorbed, for example, if the object is a product formed by compressing starch or other powders or granules, it is difficult to inspect because the light does not pass through the interior. There is a problem of becoming.
  • Patent Document 1 does not present a specific solution for this problem, the technique described in Patent Document 1 cannot be applied in an actual factory.
  • Patent Document 2 exemplifies chocolate as an object having a strong light scattering.
  • a light scattering stronger than that of food such as tablets formed by compression molding of powder
  • a weaker transmitted light is obtained. Since it is necessary to detect, measurement time becomes long.
  • an object of the present invention is to provide a foreign matter inspection apparatus and a foreign matter inspection method capable of determining the presence or absence of foreign matter mixed inside an object at a sufficiently high speed without causing destruction. It is another object of the present invention to provide a manufacturing apparatus that can improve the yield by utilizing such determination.
  • a foreign matter inspection apparatus includes a light source for irradiating light so as to cover all of a plurality of objects held together, and a plurality of the light beams emitted from the light source.
  • a detection unit that collectively receives light transmitted through any one of the objects and detects a spectrum
  • a storage unit for storing reference data, spectral data of light detected by the detection unit, and
  • a determination unit that determines whether or not a foreign object is included in at least one of the plurality of objects based on reference data.
  • the presence or absence of foreign matter mixed in the object can be determined at a sufficiently high speed without destruction.
  • FIG. 1 It is a conceptual diagram of the foreign material inspection apparatus in Embodiment 1 based on this invention. It is a fragmentary sectional view of the holding
  • Embodiment 7 It is a conceptual diagram of the foreign material inspection apparatus in Embodiment 7 based on this invention. It is a conceptual diagram of the foreign material inspection apparatus in Embodiment 8 based on this invention. It is a flowchart of the foreign material inspection method in Embodiment 9 based on this invention. It is a flowchart of the foreign material inspection method in Embodiment 10 based on this invention. It is a conceptual diagram of the manufacturing apparatus in Embodiment 11 based on this invention.
  • Embodiment 1 With reference to FIGS. 1 to 7, a foreign substance inspection apparatus according to Embodiment 1 of the present invention will be described.
  • the foreign object inspection apparatus 101 includes a light source 6 for irradiating light so as to cover the entire plurality of objects 1 held together, and a plurality of objects 1 emitted from the light source 6.
  • the detection unit 7 that collectively receives the light transmitted through any one of the above and detects the spectrum
  • the storage unit 9 for holding the reference data 11, the spectrum data of the light detected by the detection unit 7 and the reference
  • a determination unit 10 that determines whether or not a foreign object is included in at least one of the plurality of objects 1 based on the data 11.
  • the foreign substance inspection apparatus 101 includes a holding unit 5 for holding a plurality of objects 1 at a time.
  • the object 1 may be a tablet, for example.
  • the object 1 may have a flat shape.
  • the object 1 may be formed by solidifying a powder.
  • the object 1 may be a medicine or a food.
  • the object 1 may be something in which some content is contained in the capsule.
  • the capsule here may be a soft capsule.
  • the light source 6 includes a light source body 6 a and a light adjustment unit 12.
  • the light source body 6a may include a halogen lamp.
  • the light source body 6a may include a plurality of halogen lamps.
  • the wavelength of the light emitted from the light source body 6a may be, for example, not less than 600 nm and not more than 2500 nm. Although the wavelength of the light to irradiate is not limited to this range, in this wavelength range, it is easy to transmit through the object 1 and does not damage the object 1 as when irradiated with ultraviolet rays. ,preferable. Furthermore, the wavelength of light may be, for example, not less than 800 nm and not more than 1600 nm.
  • the wavelength of the irradiated light is not limited to this range, but there are large absorption peaks such as starch, lactose, and crystalline cellulose contained in general tablets in the vicinity of 1600 nm of the wavelength of the light. The influence on the spectrum due to is hidden. Moreover, if the wavelength is too short or too long, light loss due to light scattering, absorption, etc. will increase. Therefore, in the present embodiment, the wavelength of light to be irradiated is preferably 800 nm or more and 1600 nm or less.
  • a halogen lamp is used as an example of the light source body 6a.
  • the type of the light source body 6a is not limited to this and may be other types of lamps.
  • the light source body 6a only needs to be a device that can emit light having a wavelength that can detect foreign matter, and may be, for example, a tungsten lamp, a phosphor, an LED, or a laser.
  • the number of light sources 6, the wavelength of light, the intensity of light, and the like are appropriately selected according to the configuration of the apparatus, the type of the object 1, and the like.
  • the object 1 is irradiated with light from one direction using one light source 6, but the present invention is not limited to this, and the light is irradiated simultaneously from different directions using two or more light sources. May be.
  • the light adjusting unit 12 may be disposed below the light source body 6a corresponding to the light source body 6a.
  • the light adjustment unit 12 includes, for example, a lens.
  • a dimming means When acquiring the reference data, a dimming means is arranged so as to block the optical path.
  • the dimming means is, for example, a neutral density filter.
  • the amount of irradiation light is required to be the same when measuring the reference data 11 and when measuring the object 1.
  • the transmitted light of the object 1 is weak, if the light amount emitted from the light source 6 is set large so that the transmitted light becomes an appropriate light amount, measurement is performed to obtain the reference data 11. At that time, an excessive amount of light enters the detection unit 7 and exceeds the dynamic range of the spectrometer.
  • the amount of light emitted from the light source 6 is set too small, the light obtained through the target 1 is too weak when measuring the target 1, and an integration time is required to detect the spectrum of this light. Will be necessary for a long time.
  • dimming means is used to solve this problem.
  • a neutral density filter is used as the dimming means.
  • the attenuation factor (transmittance) of the dimming means is preferably substantially constant at any wavelength within the wavelength range used for measurement.
  • a neutral density filter (also referred to as an “ND filter”) having an optical density (OD) of about 3 is used as a dimming means.
  • the light reduction means is not limited to the neutral density filter, and other means may be used.
  • a neutral density filter may be used instead of the neutral density filter as a light reducing means.
  • an absorption ND filter may be used.
  • the neutral density filter to be used is not limited to a single sheet, but may be a structure in which a plurality of sheets are stacked. It is also conceivable to adjust a desired OD by overlapping a plurality of neutral density filters.
  • the neutral density filter may be a plug-in type attached to the outlet of the light source 6 and detachable. When a different OD is required, it is possible to replace the filter with a different filter as appropriate.
  • the neutral density filter may be inserted at any position between the light source 6 and the detection unit 7.
  • the near-infrared wavelength contains heat rays, and it is cheaper and easier to make the neutral density filter heat resistant than to make the lens of the light adjustment unit 12 heat resistant. Therefore, in the present embodiment, the neutral density filter is provided with a certain degree of heat resistance, and the neutral density filter is disposed between the light source 6 and the light adjusting unit 12. If it arrange
  • the neutral density filter 8 may be disposed immediately before the detection unit 7 or the detection unit 7 It may be attached to the entrance. There is an advantage that the neutral density filter 8 can be easily attached and detached depending on the attachment position of the detection unit 7 in the foreign matter inspection apparatus 101.
  • the light adjustment unit 12 adjusts the traveling direction of light from the light source body 6a.
  • the light adjustment unit 12 includes, for example, a lens.
  • the irradiation light is irradiated while covering the entire object 1 in a lump so that even foreign objects mixed in the end of the object 1 can be detected.
  • the light adjustment unit 12 is focused so that such irradiation can be performed.
  • the irradiation area is set to be slightly larger than the projected area of the object 1.
  • the area of the irradiation region may be 100.1% of the projected area of the object 1.
  • the “projected area of the object 1” here is an area obtained by projecting the object 1 onto a virtual plane perpendicular to the light irradiation direction.
  • the object 1 is a tablet manufactured by a tableting method
  • the outer peripheral surface of the tablet is hard and light is difficult to transmit. Therefore, it is possible to facilitate the transmission of light by irradiating light so that it enters from other than the outer peripheral surface.
  • the irradiation direction of light is not limited to this, and irradiation may be performed from an appropriate direction according to the inspection state of the foreign matter.
  • the lens preferably has a certain degree of heat resistance.
  • the light adjusting unit may guide the light after coming out of the light source body to a desired position with a light guide made of, for example, an optical fiber.
  • the light adjusting unit may have a configuration in which a lens is disposed at the tip of such a light guide. In this case, although light loss may occur inside the light guide means, there is an advantage that light irradiation can be easily performed from a position close to the object.
  • the light adjusting unit 12 may include a shutter that blocks light.
  • the shutter is provided as described above, the shutter is closed to block the light in accordance with the conveyance of the object so that the light from the object 1 that has been measured does not enter the detection unit 7 and become noise. Can do.
  • the shutter is provided in this way, even when it is desired to temporarily stop light irradiation for sample exchange or the like to perform some work, the shutter is closed, and the light source is kept on and the external light is kept on. In this case, it is possible to realize a state in which light is not irradiated, and a desired operation can be continued, so that the time required for starting up the light source can be saved.
  • the light source is, for example, a halogen lamp, the time required for starting up the halogen lamp can be saved, which is effective.
  • the holding part 5 has a plurality of holes 5a.
  • the hole 5a is a translucent part.
  • a partial cross-sectional view of the holding portion 5 is shown in FIG.
  • a partial perspective view of the holding portion 5 is shown in FIG.
  • the hole 5 a is larger than the outer shape of the object 1.
  • maintenance part 5 contains the 1st part 5b and the 2nd part 5c.
  • the first portion 5b is made of a material that does not transmit light.
  • the second portion 5c is formed of a material that transmits light. As shown in FIG.
  • the first portion 5b exists not only on the upper side of the second portion 5c but also on the lower side. As shown in FIG. 2, the second portion 5c may be sandwiched from above and below by the first portion 5b.
  • the second portion 5c has an opening 5c1.
  • the diameter of the opening 5 c 1 is smaller than the outer diameter of the object 1.
  • the object 1 can be supported by the second portion 5c inside the hole 5a.
  • the first portion 5b is less permeable to near infrared light so that stray light from the outside does not enter.
  • the first portion 5b can be realized by forming a member using a material having low permeability such as black alumite.
  • the first portion 5b can be realized by forming a member with another material and then coating with a material having low permeability such as black alumite. Since the holding part 5 has a plurality of holes 5a, the holding part 5 can hold a plurality of objects 1 at the same time. The plurality of objects 1 are held in a state where they are arranged in a range in which light directed to a certain region can be collectively covered by the light adjusting unit 12.
  • the holding part 5 has a hole 5a, and the object 1 is held by being placed inside the hole 5a, but this is only an example.
  • the object 1 is not limited to the hole as long as the object 1 can be held and the passage of the transmitted light can be secured to a sufficient extent to measure the transmitted light.
  • the second portion 5c is provided to support the object 1, and the second portion 5c has the opening 5c1, but in order to prevent the transmitted light from being blocked as much as possible.
  • the area of the opening 5c1 may be, for example, 90% of the surface area of the surface where the object 1 is in contact with the second portion 5c. This ratio is not limited to 90%, and may be 95%, for example.
  • the second portion 5c is plate-shaped and may be referred to as a “support plate”.
  • the second portion 5c may be formed using a transparent member having a wavelength characteristic that transmits light.
  • quartz glass or synthetic quartz glass can be employed as a material of the second portion 5c.
  • the second portion 5c is not limited to being transparent with respect to the wavelength of transmitted light.
  • the second portion 5c can be configured to be translucent or opaque.
  • the selection range of the material is widened, so that a material that can easily hold the object can be selected.
  • the ratio of noise light passing through the gap between the object 1 and the holding unit 5 may increase.
  • the second portion 5c is opaque, such noise light may be emitted. Can be blocked.
  • a lens 14 is disposed below the holding unit 5.
  • the light transmitted through the object 1 held by the holding unit 5 is collected by the lens 14 and enters the detection unit 7.
  • the light may be guided from the holding unit 5 to the detection unit 7 by a light guide made of an optical fiber.
  • a shutter for blocking light at the entrance of the detection unit 7 may be disposed in a freely openable / closable state. In this way, the light can be blocked by closing the shutter so that the light from the object that has been measured does not enter the detector 7 and become noise. In addition, if the shutter is arranged in this way, it is advantageous in that the light can be blocked when it is desired to temporarily prevent the strong light from entering the detection unit 7.
  • a polychromator type spectroscope may be used for the detection unit 7, for example.
  • a polychromator type spectroscope a large number of light receiving elements are arranged at the end of a prism that divides light into each wavelength, and light of each wavelength can be measured simultaneously.
  • the polychromator type spectrometer is also called a multi-channel detector.
  • the polychromator type spectrometer has the advantage of high measurement time.
  • Polychromators include those using a light receiving element and a prism, and those using a CCD.
  • the type of polychromator is appropriately selected according to the configuration of the inspection apparatus, the type of tablet to be measured, the wavelength of light, and the like.
  • a system in which an InGaAs light receiving element and a prism, which are more accurate than a CCD, are combined is used.
  • the spectroscope provided in the detector 7 measures the spectrum of the received light.
  • the detection unit 7 does not necessarily include a spectroscope.
  • the detection unit 7 may be configured to include any of a photodiode, a phototransistor, an avalanche photodiode, and a photomultiplier tube, for example.
  • the number and arrangement of the light receiving elements in the detection unit 7 are appropriately selected according to the configuration of the foreign substance inspection apparatus, the type of the object to be measured, the wavelength of light used, and the like.
  • the foreign substance inspection apparatus 101 may include a control unit 13.
  • the control unit 13 controls the light source 6, the storage unit 9, the detection unit 7, the transport unit, and the like.
  • the control unit 13 may control the opening and closing of the shutter.
  • Each process by the control part 13 may be implement
  • the determination unit 10 performs an operation with reference to the measurement data of the object 1 obtained by the detection unit 7 based on the transmitted light and the data stored in the storage unit 9, and foreign matter mixed in the object 1. Whether or not is included is determined.
  • the determination unit 10 is illustrated as being different from the control unit 13, but the determination unit 10 may be provided as a part of the control unit. The control unit may also serve as the determination unit.
  • the storage unit 9 is for storing information necessary for inspection.
  • the storage unit 9 includes, for example, an area for temporarily storing measurement data from the detection unit 7, various programs executed by the control unit, an area for storing data used in these programs, and these programs. An area to be loaded and a work area used when these programs are executed are provided.
  • the various programs are, for example, a program for making a determination, a calculation algorithm, a database, and the like.
  • the storage unit 9 can hold reference data 11 used for determination by the determination unit 10.
  • the lens of the light adjusting unit 12 Prior to the inspection, the lens of the light adjusting unit 12 is previously focused so that the irradiation light covers the target 1 when the target 1 is in the holding unit 5. That is, the focus is adjusted so that the irradiation light covers at least 100% of the cross-sectional area of the object 1 in a plane perpendicular to the irradiation light.
  • the irradiation area is set to be slightly larger than the object 1. Here, it is 100.1% of the total cross-sectional area.
  • Measurement conditions that can be artificially changed such as the irradiation time of light, the amount of irradiation light, the slit width of the spectrometer, the integration time, the average number of times, the set temperature, and the sensitivity, are predetermined according to the type of the object 1 and We will not change these conditions during this period.
  • the holding unit 5 present at the measurement position holds one object 1 and irradiates light for each object 1 for a certain period of time.
  • the light irradiation time is set to a time short enough to avoid inappropriate heating of the object 1. In the present embodiment, the irradiation time is 0.8 seconds per time.
  • the light source 6 only needs to be a light source that can irradiate light for a short time.
  • a flash-type lamp or chopper may be used.
  • irradiation is performed for a short time of 0.8 seconds per object 1, but the irradiation time is not limited to this. Increasing the amount of light makes it easier for light to pass through the object 1, so the irradiation time may be lengthened depending on the type of the object 1.
  • the irradiation light includes heat rays, the object 1 is heated when irradiated with light. The temperature rises as the amount of light to be irradiated is increased and the irradiation time is lengthened. Depending on the type of the object 1, the component is altered by being heated too much. In the case where the object 1 has already been heated and heated in a drying process or the like prior to the inspection process, the temperature is set as the upper limit.
  • the temperature in the drying step or the like performed before is generally kept below the temperature at which the components of the object 1 are altered. That is, the degree of temperature rise determined by the irradiation time and the amount of light to be irradiated is set to be equal to or lower than the temperature generated in any process performed before the inspection process, and the amount of irradiation light is made as large as possible within the range satisfying this condition, and the measurement time Is preferably shortened.
  • the upper limit of the irradiation time and the irradiation light amount is appropriately determined depending on the component and structure of the object 1.
  • the holding unit 5 may have a configuration shown in FIGS. 4 and 5, for example.
  • the holding part 5 has a hole 5a and includes a protrusion 5e protruding toward the inside of the hole 5a.
  • FIG. 4 is a cross-sectional view of the state in which the object 1 is placed on the holding unit 5
  • FIG. 5 is a plan view of the vicinity of the holding unit 5 without the object 1.
  • the three protrusions 5e are provided at equal intervals of about 120 °.
  • the number of protrusions 5e may be other than three.
  • the arrangement angles of the protrusions 5e need not be equal.
  • the holding part 5 includes a first part 5b, a second part 5c, and a lens 5d, and the second part 5c has an opening.
  • the opening of the second portion 5c has a mortar shape. It is preferable that the opening part of the 2nd part 5c becomes a mortar shape that the shape of the target object 1 fits.
  • a measurement for obtaining the reference data 11 is performed before inspecting the object 1, a measurement for obtaining the reference data 11 is performed.
  • the measurement for acquiring the reference data 11 needs to be performed at least once before the inspection of the object 1 is started. This measurement is performed with the foreign matter inspection apparatus 101 in the first state.
  • the measurement for acquiring the reference data 11 is to be performed again.
  • the selection is appropriately made according to the configuration of the inspection apparatus, the type of the object to be measured, the wavelength of light, and the like.
  • the measurement for obtaining the reference data 11 is performed, for example, 1 day before the start of the morning inspection and before the start of the afternoon inspection. You only have to do it once.
  • the ND filter used at this time is determined according to the type of the object.
  • the inspection of the object 1 is started.
  • the holding unit 5 With the plurality of objects 1 installed on the holding unit 5, the holding unit 5 is arranged in the light irradiation region. At this time, the position of the holding unit 5 is the same as the position when the reference data is measured. 6).
  • a plurality of objects 1 are irradiated with light. 7).
  • the light passes through the plurality of objects 1.
  • “transmission” includes passing through the object 1 while being scattered (including multiple scattering). 8).
  • the light transmitted through the plurality of objects 1 is collected by the lens 14 and enters the detection unit 7.
  • the spectroscope provided in the detection unit 7 measures the light intensity I for each wavelength.
  • the measurement result is stored in the storage unit 9 as measurement data.
  • the transmitted light includes information inside the object 1.
  • the determination unit 10 performs conversion for extracting information on the foreign matter from the difference between the incident light and the transmitted light using the measured light intensity.
  • the determination unit 10 determines the presence or absence of foreign matter from the calculated absorbance A1.
  • discriminant analysis is used.
  • a calculation model for calculating the class predicted value and the similarity of the sample from the absorbance is used.
  • the calculation model derivation method includes support vector machine, pattern recognition, Mahalanobis distance analysis, SIMCA (Soft Independent Modeling of Class Analysis) discriminant analysis, canonical discriminant analysis method and the like.
  • the calculation model may be determined by selecting an optimum derivation method according to the purpose of what kind of object to be determined.
  • a calculation model for determining the characteristics of a foreign substance contained in a tablet as a target object is derived by the PLS-DA (Partial Linear Square-Discriminant Analysis) method, and the value calculated from the tablet measurement data using this calculation model is Foreign matter contamination is determined based on whether or not the reference value is greater than a preset reference value.
  • a calculation model for performing the calculation is determined by the wavelength of light to be irradiated, the type of tablet, the configuration of the transport unit of the inspection apparatus, and the like, and is stored in the storage unit 9 in advance.
  • the determination unit 10 refers to the absorbance obtained from the measurement result in the detection unit 7 and the calculation model for each type of tablet read from the database stored in the storage unit 9 to calculate an index indicating the characteristics of the tablet. The presence / absence of foreign matter is determined.
  • the determination unit 10 can make a determination using a relational database or a correspondence table, or a plot using a graph as appropriate, depending on the type of tablet.
  • a calculation model for calculating a predicted value and a bias value is used as an index for determining whether the tablet is a normal tablet or a tablet mixed with hair. If the predicted value calculated from the calculation model is 0.5 or more and the bias value is less than 0.5, it is “normal”, and if the predicted value is less than 0.5 and the bias value is less than 0.5, “hair is mixed. Can be determined. In addition, when the predicted value is less than 0.5 and the deviation value is 0.5 or more, it cannot be specified that the hair is mixed, but insects are mixed inside or some abnormality such as cracking occurs. It can be considered that there is a high possibility. In this case, the type of abnormality can be specified using still another calculation model. For example, if an index indicating whether the tablet is a normal tablet or a tablet in which insects are mixed can be calculated, the presence or absence of insects can be detected.
  • a plurality of indices can be calculated and plotted on a graph, and the determination can be made by region.
  • the determination value A and the determination value B are calculated using two indices, respectively, and plotted using these. It can be judged normal if it is above a predetermined reference line as plotted by a black circle, and abnormal if it is below the reference line as plotted by a white circle.
  • two-dimensional plotting is performed, but the present invention is not limited to two-dimensional plotting.
  • three-dimensional plotting may be performed using three indexes, and contamination of foreign matter may be determined based on whether or not the plotting is performed in an area where it is confirmed that a normal tablet is plotted in advance.
  • the target object 1 determined to be contaminated with foreign matter or the lot including the same is discarded.
  • the holding unit 5 since the inspection is performed in a state where a plurality of objects 1 are held by one holding unit 5, when it is determined that foreign matter is mixed, the holding unit 5 normally It is assumed that all objects 1 held are discarded.
  • the present embodiment since a plurality of objects can be inspected at the same time, the presence or absence of foreign matter mixed in the object can be determined at a sufficiently high speed without destruction. Since this embodiment can be applied when a large number of objects are to be efficiently inspected over the entire number, it is suitable for inspection in a factory.
  • the light source 6 expands to such an extent that the light source main body 6a and the light emitted from the light source main body 6a are transmitted or reflected to cover the entire plurality of objects 1. It is preferable that the light adjusting unit 12 as an optical member is provided, and the light emitted from the light source body 6a reaches the plurality of objects 1 after being expanded by the light adjusting unit 12 as an optical member.
  • the optical member is the light adjustment unit 12
  • the optical member is not limited to the light adjustment unit 12.
  • the optical member may be a diffusion plate 15.
  • the light source 6 may include a plurality of light source elements 6e, and each light source element 6e may include a light adjusting unit 12 individually.
  • the light source element 6e may be a light bulb such as a halogen lamp.
  • the foreign substance inspection apparatus 101 includes a holding unit 5 for holding a plurality of objects, and the holding unit 5 arranges the plurality of objects 1 two-dimensionally. It may be provided with a tray for holding it in a state in which it is placed. Since the holding unit 5 includes the tray in this way, it becomes easy to handle a plurality of objects 1 in a certain number.
  • the tray may be the holding unit 5 itself, or may be a part of the holding unit 5.
  • the tray may be for holding a plurality of objects 1 in a matrix array. As described above, it is preferable that a plurality of objects 1 are efficiently held in a limited area if they are held in a matrix arrangement.
  • the wavelength of light emitted from the light source 6 is preferably 800 nm or more and 1500 nm or less. Furthermore, the wavelength of light emitted from the light source 6 is preferably 800 nm or more and 1600 nm or less. The reason is as described in the explanation regarding the light source.
  • the foreign substance inspection apparatus 101 includes a holding unit 5 for holding a plurality of objects, and the holding unit 5 includes a number of light transmitting units corresponding to the plurality of objects 1. And covering at least a part of the inner region of the light-transmitting part so as to support the object 1 from below when each of the plurality of objects 1 is individually arranged at a position corresponding to the light-transmitting part. It is preferable that the light directed from the light source 6 toward the detection unit 7 passes through the light transmission unit.
  • the “translucent portion” may be, for example, the hole 5a shown in FIG.
  • the hole 5a is a through hole.
  • the translucent portion is not limited to the through hole, and may be a portion where light can pass through anyway.
  • the translucent part may be a gap between some members, for example.
  • the translucent portion may be a portion where some translucent member is disposed. It may be a portion that is partially or completely blocked by some translucent member.
  • the part other than the light transmitting part of the member having the light transmitting part may be the first part 5b.
  • the “supporting portion” may be, for example, a portion in which the second portion 5c shown in FIG. 2 protrudes inside the hole 5a.
  • the support portion is not limited to projecting over the entire circumference in this way, and one or more projections may project inward.
  • the support portion may be a projection 5e shown in FIGS.
  • the support part may be transparent.
  • the degree to which the support portion blocks the transmitted light can be reduced, and the inspection can be performed efficiently.
  • the second portion 5 c is transparent.
  • the appearance inspection may be additionally performed before or after the foreign matter determination according to the present invention. As described above, if the appearance inspection is further combined with the foreign matter inspection apparatus in the present embodiment, the foreign matter can be detected more reliably.
  • the storage unit 9 may record inspection results and inspection data such as date and temperature. For example, records concerning the status of other devices, such as the number and time of people entering and leaving a certain space, the materials used, the timing of washing the tablet press, the presence or absence of a fluorescent lamp breakage accident, etc. Good. If combined with these data and analyzed, they can be presented as comprehensive data for preventing foreign matter contamination. That is, it can be utilized as a means for preventing the recurrence of foreign matter contamination.
  • FIG. 10 shows a configuration other than the foreign matter inspection apparatus in the present embodiment.
  • the individual holding unit 5 has a tray shape.
  • a plurality of holding portions 5 are placed on the circular rotor 20.
  • the plurality of holding portions 5 are arranged in the circumferential direction along the outer edge of the rotor 20.
  • the rotor 20 rotates intermittently or continuously as indicated by an arrow 91.
  • the new holding unit 5 is arranged in a vacant space on the rotor 20 by being supplied from the feeder 21.
  • the light source 6 includes a light source body 6 a and a light adjustment unit 12.
  • the light source 6 is disposed so as to irradiate light to one of the plurality of holding units 5 arranged on the rotor 20.
  • the detection unit 7, the determination unit 10, the control unit 13, and the like are not shown.
  • the holding unit 5 in which no foreign matter is detected is discharged from the OK chute 22.
  • the holding unit 5 in which the foreign matter is detected is discharged from the NG chute 23.
  • the new holding unit 5 is successively carried into the light irradiation area by the light source 6 by the circular rotor 16, even when a large number of holding units 5 are to be inspected, foreign object inspection can be performed efficiently. Can be performed.
  • the objects 1 are arranged in a matrix in the holding unit 5, but as shown in FIG. 11, even if the objects 1 are stacked in the container 16. Good. Furthermore, as shown in FIG. 12, a plurality of objects 1 may be randomly placed in the container 17.
  • the container 17 has a cylindrical shape, but the shape of the container 17 is not limited to the cylindrical shape, and may be, for example, a square shape when viewed from above.
  • the plurality of objects 1 are stacked, but may be arranged without being stacked.
  • the plurality of objects may be arranged randomly or regularly. For example, a plurality of objects may be arranged in a matrix so as not to overlap each other in the container.
  • Embodiment 3 With reference to FIG. 13, the foreign substance inspection apparatus in Embodiment 3 based on this invention is demonstrated.
  • the basic configuration of foreign object inspection apparatus 102 in the present embodiment is the same as that in the first embodiment, but the configuration of the holding unit is different from that in the first embodiment.
  • a holding unit 5e is used instead of the holding unit 5.
  • a certain number of objects 1 form a group.
  • the holding unit 5e is configured so that a plurality of groups of objects 1 can be arranged simultaneously.
  • the light source 6 does not irradiate all the objects 1 on the holding unit 5e with light at the same time, but irradiates light toward all the objects 1 belonging to one group on the holding unit 5e.
  • the determination unit 10, the control unit 13, and the like are not shown.
  • a larger number of objects 1 than can be arranged in a single light irradiation region can be collectively held, and light irradiation can be performed sequentially for each group. Therefore, it is suitable for promptly inspecting a large number of objects 1.
  • Embodiment 4 With reference to FIG. 14, the foreign substance inspection apparatus in Embodiment 4 based on this invention is demonstrated.
  • the foreign substance inspection apparatus 103 according to the present embodiment has the same basic configuration as that of the first embodiment, but differs from the first embodiment with respect to the configuration of the holding unit. As shown in FIG. 14, in the present embodiment, a holding unit 5 f is used instead of the holding unit 5.
  • the foreign substance inspection apparatus 103 emits light from a light source 6 for irradiating light so as to cover two or more objects 1 among a plurality of objects 1 being sequentially conveyed. Then, a detection unit 7 that collectively receives light transmitted through one of the two or more objects 1 to detect a spectrum, a storage unit 9 that holds reference data 11, and a detection unit 7 A determination unit that determines whether or not a foreign object is included in at least one of the plurality of objects based on the detected spectrum data of the light and the reference data.
  • the foreign object inspection apparatus 103 includes a holding unit 5f for sequentially transporting the plurality of objects 1.
  • the holding unit 5f is preferably a conveyor that holds and conveys the plurality of objects 1 in a two-dimensional array.
  • a state other than the two-dimensionally arranged state for example, a state in which the object 1 is partly stacked on the conveyor and placed in a random positional relationship can be cited. Although it may be in such a state, it is preferable that the plurality of objects 1 are regularly and two-dimensionally arranged.
  • the holding part 5f may be an endless conveyor.
  • the target objects 1 are arranged in a plurality of rows on a holding portion 5f that is an endless conveyor, but as a foreign object inspection apparatus 104 shown in FIG.
  • the part 5h may be provided.
  • the objects 1 are arranged in one row.
  • the objects 1 conveyed by the conveyor can be inspected one after another, which is efficient.
  • Embodiment 5 With reference to FIG. 16, the foreign substance inspection apparatus in Embodiment 5 based on this invention is demonstrated.
  • the lens 14 is arranged as the light collecting means below the holding unit 5.
  • a reflector 18 is arranged instead of the lens 14 as shown in FIG. .
  • the light transmitted through the object 1 is collected while being reflected by the reflector 18 and enters the detection unit 7.
  • the light can be collected in a desired direction depending on the attitude of the reflector 18, so that the degree of freedom of the installation position of the detection unit 7 can be increased.
  • Embodiment 6 With reference to FIG. 17, the foreign substance inspection apparatus in Embodiment 6 based on this invention is demonstrated.
  • the lens 14 is arranged as the light condensing means below the holding portion 5, but in this embodiment, a lens is provided near the exit of the hole 5a as shown in FIG. 5d is arranged.
  • the lens 5d is individually provided so as to correspond to each of the objects 1.
  • the lens 5 d may be a part of the holding unit 5.
  • the light transmitted through the object 1 is collected by the lens 5 d and enters the detection unit 7.
  • the light transmitted through the object 1 can be collected by the lens 5d at a position close to the object 1, the light transmitted through the object 1 can be efficiently used for inspection. .
  • Embodiment 7 With reference to FIG. 18, the foreign substance inspection apparatus in Embodiment 7 based on this invention is demonstrated.
  • the present invention is not limited to this, and two or more light sources are used from different directions. It may be irradiated.
  • irradiation is performed from one side of holding unit 5 toward target object 1 using light sources 6i and 6j.
  • the light transmitted through the object 1 is guided to the detection unit 7 by the lens 14.
  • the light source 6 i includes a light source body 6 a 1 and a light adjustment unit 12.
  • the light source 6j includes a light source body 6a2 and a light adjusting unit 12.
  • light is transmitted from the lower side of the holding unit 5 toward the upper side.
  • the configuration of other parts, the usage method, and the like are the same as those described in the first embodiment.
  • Embodiment 8 With reference to FIG. 19, the foreign substance inspection apparatus in Embodiment 8 based on this invention is demonstrated.
  • the light transmitted through the object 1 is received by the detection unit 7, but not only the transmitted light but also reflected light may be used.
  • a plurality of concave portions are provided in the holding portion 5, and the bottom surface of each concave portion reflects light transmitted through the object 1. It is formed as a surface.
  • the light transmitted through each object 1 is reflected by the bottom surface of the concave portion of the holding unit 5 and is transmitted again through the object 1. In this way, the light transmitted through each object 1 and traveling in the direction away from the holding unit 5 is collected by the lens 14 and received by the detection unit 7.
  • the foreign matter inspection apparatus includes a holding unit 5 for holding a plurality of objects 1, and the holding unit 5 has a reflecting surface and temporarily transmits any one of the plurality of objects 1. At least a part of the light that has been reflected is reflected by the reflecting surface, passes through one of the plurality of objects 1 again, and then enters the detection unit 7.
  • the configuration of other parts, the usage method, and the like are the same as those described in the first embodiment.
  • the same effects as described in the first embodiment can be obtained also by the foreign substance inspection apparatus in the present embodiment.
  • the present embodiment since the light reaches the detection unit 7 after passing through the inside of the object 1 twice, a more accurate inspection can be performed.
  • FIG. 20 shows a flowchart of the foreign substance inspection method in this embodiment.
  • This foreign matter inspection method is a foreign matter inspection method for determining whether or not foreign matter is mixed in at least one of a plurality of objects, and includes a step S1 of holding the plurality of objects collectively and the plurality of objects.
  • a step of irradiating light from the light source so as to cover the whole of the object, and light that has transmitted at least once through the plurality of objects among the light from the light source is collectively collected by the detection unit Step S3 of detecting spectrum data of light received by the detection unit as measurement data, and whether foreign objects are mixed in at least one of the plurality of objects based on the measurement data and reference data Step S4 for determining whether or not.
  • FIG. 21 shows a flowchart of the foreign substance inspection method in this embodiment.
  • This foreign matter inspection method is a foreign matter inspection method for determining whether or not foreign matter is mixed in at least one of a plurality of objects, and sequentially holds and sequentially transports the plurality of objects.
  • the detection unit collectively receives the light, and detects the spectrum data of the light received by the detection unit as measurement data, and based on the measurement data and the reference data, And step S4 for determining whether or not foreign matter is mixed in at least one of the plurality of objects.
  • the present embodiment it is possible to determine the presence or absence of foreign matter mixed inside the object 1 in a nondestructive manner.
  • foreign object inspection of a plurality of objects 1 can be performed quickly.
  • the manufacturing apparatus in this Embodiment is an apparatus for manufacturing the target object 1, Comprising: It is a manufacturing apparatus provided with the foreign material inspection apparatus of one of the structures demonstrated so far. This manufacturing apparatus is shown in FIG. What is shown in FIG. 22 is conceptual only, and the layout of the manufacturing apparatus is not necessarily such.
  • the manufacturing apparatus 501 includes a production unit 301 that produces the object 1, and further includes a foreign substance inspection apparatus 101.
  • the object 1 produced by the production unit 301 is inspected by the foreign substance inspection apparatus 101.
  • the conveyance of the object 1 to the foreign matter inspection apparatus 101 is performed by, for example, the conveyance apparatus 302.
  • the conveyance device 302 conveys the object 1 stored in the cassette.
  • the conveyance device 302 shown here is merely an example, and is not limited to such a form.
  • the manufacturing apparatus in the present embodiment only the object 1 that has been determined by the foreign substance inspection apparatus 101 to be free of foreign matters is obtained as a manufactured product. Therefore, in this Embodiment, a target object can be manufactured efficiently. In particular, when foreign matter is mixed in the object, it can be appropriately detected and eliminated as a defective product, so that the yield can be improved.
  • the production unit 301 and the foreign substance inspection apparatus 101 are shown as apparatuses that are housed in separate housings. However, this is merely an example, and the two are integrated. And may be housed in a single housing.
  • a tablet that is, a tablet is shown as the target object 1.
  • the present invention is not limited to a tablet form, and can be applied to a powder, a granule, a capsule, and a film.
  • the object 1 may be, for example, a medicine, a drug, a food, a health maintenance intake, and the like.
  • Each of the plurality of objects may be any one selected from the group consisting of medicines, pharmaceuticals, health maintenance intakes, nutrients, granules, powders, films, and capsules.
  • a discriminant analysis technique is used, but the present invention is not limited to this.
  • any other method may be used as long as it is a method capable of discriminating contamination by using the absorbance calculated for the different wavelengths of light to be irradiated.
  • other analysis methods such as a canonical discriminant analysis method may be used.
  • each of the plurality of objects 1 is manufactured by the tableting method, and the light from the light source 6 is in the same direction as the direction pressed during the manufacturing by the tableting method. It is preferable that any one of the plurality of objects 1 is transmitted along. This is because the light transmittance is improved in this direction.

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating Materials By The Use Of Optical Means Adapted For Particular Applications (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

Le dispositif d'inspection de substance étrangère (101) de l'invention est équipé : d'une source lumineuse (6) destinée à l'irradiation d'une lumière de manière à couvrir l'ensemble d'une pluralité d'objets conservée collectivement ; d'une partie détection (7) qui reçoit collectivement la lumière émise en sortie par la source lumineuse (6) et passée au travers de l'un des objets, et en détectant le spectre ; d'une partie mémoire (9) destinée à conserver des données de référence (11) ; et d'une partie jugement (10) qui juge si une substance étrangère est contenue ou non dans au moins un des objets (1) sur la base de données relatives au spectre de la lumière détectée par la partie détection (7) et des données de référence (11).
PCT/JP2017/045967 2017-01-17 2017-12-21 Dispositif d'inspection de substance étrangère, procédé d'inspection de substance étrangère, et dispositif de fabrication WO2018135232A1 (fr)

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JP2021183070A (ja) * 2020-05-22 2021-12-02 株式会社湯山製作所 錠剤識別支援装置
JP2022040949A (ja) * 2020-08-31 2022-03-11 アンリツ株式会社 物品検査装置

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JP7199697B2 (ja) * 2018-11-16 2023-01-06 株式会社Ps&T 検査装置、検査方法、プログラム、記録媒体および粉体成形物製造装置

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WO2008001785A1 (fr) * 2006-06-26 2008-01-03 Toshiba Solutions Corporation APPAREIL d'inspection de spécimen, et procédé d'inspection de spécimen
JP2011191129A (ja) * 2010-03-12 2011-09-29 Hitachi Information & Control Solutions Ltd 錠剤検査装置、錠剤包装装置、錠剤検査方法及び錠剤包装方法
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Publication number Priority date Publication date Assignee Title
JP2021183070A (ja) * 2020-05-22 2021-12-02 株式会社湯山製作所 錠剤識別支援装置
JP2022040949A (ja) * 2020-08-31 2022-03-11 アンリツ株式会社 物品検査装置
JP7325390B2 (ja) 2020-08-31 2023-08-14 アンリツ株式会社 物品検査装置

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