WO2018104772A1 - Préparation de type à absorption percutanée - Google Patents

Préparation de type à absorption percutanée Download PDF

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Publication number
WO2018104772A1
WO2018104772A1 PCT/IB2017/001501 IB2017001501W WO2018104772A1 WO 2018104772 A1 WO2018104772 A1 WO 2018104772A1 IB 2017001501 W IB2017001501 W IB 2017001501W WO 2018104772 A1 WO2018104772 A1 WO 2018104772A1
Authority
WO
WIPO (PCT)
Prior art keywords
acid
drug
containing layer
tramadol
transdermal
Prior art date
Application number
PCT/IB2017/001501
Other languages
English (en)
Japanese (ja)
Inventor
傑 石川
貴史 才
Original Assignee
王子ホールディングス株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 王子ホールディングス株式会社 filed Critical 王子ホールディングス株式会社
Publication of WO2018104772A1 publication Critical patent/WO2018104772A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Abstract

La présente invention concerne une préparation de type à absorption percutanée comportant du tramadol ou un sel pharmaceutiquement acceptable de ce dernier, ladite préparation de type à absorption percutanée maintenant la perméabilité cutanée du tramadol sans provoquer de saignement et maintenant également l'agrégabilité. Plus précisément, la présente invention porte sur une préparation de type à absorption percutanée comprenant un support et une couche comportant un médicament, la couche comportant un médicament comportant du tramadol ou un sel pharmaceutiquement acceptable de ce dernier, un alcanolamide d'acide gras, de l'acide silicique et un adhésif.
PCT/IB2017/001501 2016-12-05 2017-12-04 Préparation de type à absorption percutanée WO2018104772A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2016-235652 2016-12-05
JP2016235652A JP6695571B2 (ja) 2016-12-05 2016-12-05 経皮吸収型製剤

Publications (1)

Publication Number Publication Date
WO2018104772A1 true WO2018104772A1 (fr) 2018-06-14

Family

ID=62491661

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2017/001501 WO2018104772A1 (fr) 2016-12-05 2017-12-04 Préparation de type à absorption percutanée

Country Status (2)

Country Link
JP (1) JP6695571B2 (fr)
WO (1) WO2018104772A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114269330A (zh) * 2019-06-28 2022-04-01 帕斯帕特技术有限公司 透皮药物递送贴片、药物递送系统和药物递送方法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07304672A (ja) * 1994-05-06 1995-11-21 Nitto Denko Corp 経皮吸収製剤
WO2000061120A1 (fr) * 1999-04-13 2000-10-19 Hisamitsu Pharmaceutical Co., Inc. Préparations destinées à être absorbées par voie percutanée
JP2001231812A (ja) * 2000-02-25 2001-08-28 Teikoku Seiyaku Co Ltd 貼付剤用支持体およびそれを用いた外用貼付剤
WO2003013613A1 (fr) * 2001-08-10 2003-02-20 Hisamitsu Pharmaceutical Co., Inc. Preparation medicinale a absorption percutanee
JP2006169238A (ja) * 2004-11-22 2006-06-29 Hisamitsu Pharmaceut Co Inc 薬物含有貼付剤
WO2009066457A1 (fr) * 2007-11-22 2009-05-28 Medrx Co., Ltd. Composition de préparation externe comprenant du liquide ionique à base d'acides gras en tant qu'ingrédient actif
WO2010016219A1 (fr) * 2008-08-05 2010-02-11 株式会社メドレックス Préparation externe comprenant un sel d'acide gras ou un sel d'acide benzoïque d'un composant basique pharmacologiquement actif, et procédé de production de celui-ci
JP2011020997A (ja) * 2009-03-19 2011-02-03 Kyoritsu Yakuhin Kogyo Kk 外用貼付剤

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09143066A (ja) * 1995-11-24 1997-06-03 Sekisui Chem Co Ltd 貼付剤
JPH09208463A (ja) * 1996-02-07 1997-08-12 Tsumura & Co 経皮吸収性に優れた消炎鎮痛組成物
JP5489112B2 (ja) * 2009-09-03 2014-05-14 トーアエイヨー株式会社 貯蔵安定性を改善した貼付剤包装品

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07304672A (ja) * 1994-05-06 1995-11-21 Nitto Denko Corp 経皮吸収製剤
WO2000061120A1 (fr) * 1999-04-13 2000-10-19 Hisamitsu Pharmaceutical Co., Inc. Préparations destinées à être absorbées par voie percutanée
JP2001231812A (ja) * 2000-02-25 2001-08-28 Teikoku Seiyaku Co Ltd 貼付剤用支持体およびそれを用いた外用貼付剤
WO2003013613A1 (fr) * 2001-08-10 2003-02-20 Hisamitsu Pharmaceutical Co., Inc. Preparation medicinale a absorption percutanee
JP2006169238A (ja) * 2004-11-22 2006-06-29 Hisamitsu Pharmaceut Co Inc 薬物含有貼付剤
WO2009066457A1 (fr) * 2007-11-22 2009-05-28 Medrx Co., Ltd. Composition de préparation externe comprenant du liquide ionique à base d'acides gras en tant qu'ingrédient actif
WO2010016219A1 (fr) * 2008-08-05 2010-02-11 株式会社メドレックス Préparation externe comprenant un sel d'acide gras ou un sel d'acide benzoïque d'un composant basique pharmacologiquement actif, et procédé de production de celui-ci
JP2011020997A (ja) * 2009-03-19 2011-02-03 Kyoritsu Yakuhin Kogyo Kk 外用貼付剤

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114269330A (zh) * 2019-06-28 2022-04-01 帕斯帕特技术有限公司 透皮药物递送贴片、药物递送系统和药物递送方法

Also Published As

Publication number Publication date
JP2018090539A (ja) 2018-06-14
JP6695571B2 (ja) 2020-05-20

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