WO2018092889A1 - Matériau de traitement de surface dentaire de type à un seul matériau - Google Patents

Matériau de traitement de surface dentaire de type à un seul matériau Download PDF

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Publication number
WO2018092889A1
WO2018092889A1 PCT/JP2017/041505 JP2017041505W WO2018092889A1 WO 2018092889 A1 WO2018092889 A1 WO 2018092889A1 JP 2017041505 W JP2017041505 W JP 2017041505W WO 2018092889 A1 WO2018092889 A1 WO 2018092889A1
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Prior art keywords
silver
iodide
salt
surface treatment
tooth surface
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PCT/JP2017/041505
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English (en)
Japanese (ja)
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憲司 畑中
直樹 西垣
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クラレノリタケデンタル株式会社
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Priority to JP2018551713A priority Critical patent/JP7142574B2/ja
Publication of WO2018092889A1 publication Critical patent/WO2018092889A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention relates to a tooth surface treatment material that is one-material type, easy to handle, excellent in storage stability, suppresses the progress of caries without impairing the aesthetic surface of the treatment site, and suppresses hypersensitivity.
  • the rate of remaining teeth among elderly people is increasing due to the improvement of dental treatment technology and enlightenment activities represented by the 8020 movement.
  • the level of regular oral care is reduced, and the simultaneous increase in dental caries on the root surface and adjacent surface has become a clinical problem.
  • Patent Document 1 discloses a two-stage tooth in which a liquid containing a silver compound (first liquid) is applied to an affected area, and then a liquid containing an alkali metal halide or alkaline earth metal halide (second liquid) is applied.
  • first liquid a liquid containing a silver compound
  • second liquid a liquid containing an alkali metal halide or alkaline earth metal halide
  • a face treatment method is described. According to this, secondary caries did not occur even after 6 months from the treatment, and no black discoloration was observed in the treatment area.
  • two chemicals are required. First, a liquid containing a silver compound is applied, dried, and then the second liquid is applied, so that an excess silver compound that causes discoloration is separated from another silver compound.
  • a complicated operation of removing from the treatment portion was necessary.
  • Patent Document 2 describes a method for reducing caries by applying a composition containing silver diammine fluoride and a carrier that allows continuous release of silver diammonium fluoride and adheres to the tooth surface to the affected area. Has been. According to this, the caries are stopped after 6 months from the treatment. However, the treatment method does not solve the problem that the affected area turns black. Thus, it is difficult to achieve both the one-material type and not to change the affected area to black after the treatment, and there has been no tooth surface treatment material that satisfies both of these points.
  • the present invention has been made to solve the above problems, and provides a tooth surface treatment material that is easy to handle with a single material type and can suppress the progression of caries without impairing the aesthetic surface of the treatment site.
  • Another object of the present invention is to provide a tooth surface treatment material that can be easily handled with a single material type and that can suppress hypersensitivity without impairing the aesthetic surface of the treatment site.
  • an object of the present invention is to provide a one-material type tooth surface treatment material that has no ammonia smell and is excellent in the feeling of use.
  • Another object of the present invention is to provide a one-part tooth surface treatment material that is excellent in storage stability.
  • an object of the present invention is to provide a one-part tooth surface treatment material excellent in acid resistance.
  • the present invention provides a one-part tooth surface treatment material containing a complex ion (A) of silver ions and iodide ions (A) and water.
  • the concentration of silver atoms present in a dissolved state in the solution is 10 to 125,000 mass ppm relative to the mass of the one-material type tooth surface treatment material. preferable.
  • the iodide ion is derived from an iodide salt (B), the silver ion is derived from a silver salt (C), and the silver salt is as follows.
  • (C) is silver diammine fluoride, silver nitrate (I), silver fluoride (I), silver chloride (I), silver bromide (I), silver carbonate (I), silver iodide (I), silver oxide (I), silver chlorate (I), silver perchlorate (I), silver chromate (I), silver hexafluoroantimonate (V), silver hexafluorophosphate (I), silver nitrite (I), It is at least one silver compound selected from the group consisting of silver sulfate (I), silver thiocyanate (I), silver vanadate, and organic silver salt, and the iodide salt (B) / silver salt (C) It is preferable that the molar ratio is not less than the lower limit value
  • the tooth surface treatment material of one material type of the present invention is derived from an iodide salt (B), and the silver ion is supplied from the silver salt (C).
  • the silver salt (C) is at least one silver compound selected from the group consisting of silver iodide (I) and organic silver salt, and the molar ratio of the iodide salt (B) / the silver salt (C)
  • the silver salt (C) is less than a lower limit value at which the silver salt (C) is completely dissolved in a one-material type tooth surface treatment material.
  • the organic silver salt is silver formate (I), silver acetate (I), silver citrate (I), silver oxalate (II), silver gluconate, propion.
  • the iodide ion is derived from an iodide salt (B), and the iodide salt (B) is sodium iodide, potassium iodide, rubidium iodide, iodine It is preferably at least one compound selected from the group consisting of magnesium iodide, calcium iodide and strontium iodide.
  • the tooth surface treatment material of one material type according to the present invention should not turn black when applied to a hydroxyapatite plate and then left to stand for 24 hours in an environment with an illuminance of 1200 lux at 25 ° C. to evaporate water. Is one of the features.
  • the one-surface type tooth surface treatment material of the present invention preferably contains a water-soluble fluoride salt (D).
  • the one-surface type tooth surface treatment material of the present invention is for preventing caries.
  • the one-surface type tooth surface treatment material of the present invention is for suppressing hypersensitivity.
  • the present invention also provides an iodide aqueous solution having an iodide salt (B) concentration of 5 to 60% by mass and a silver salt (C) in a molar ratio of iodide salt (B) / silver salt (C).
  • the manufacturing method of the one-material type tooth surface treatment material including the production
  • the present invention it is possible to provide a tooth surface treatment material that is easy to handle with a single material type and can suppress the progress of dental caries without impairing the aesthetic surface of the treatment site.
  • the present invention can provide a tooth surface treatment material that is easy to handle with a single material type and suppresses hypersensitivity without impairing the aesthetic surface of the treatment site.
  • the present invention can provide a one-material type tooth surface treatment material that has no ammonia odor and is excellent in the feeling of use.
  • Another object of the present invention is to provide a one-part tooth surface treatment material that is excellent in storage stability.
  • this invention can provide the one-material type tooth surface processing material excellent in acid resistance.
  • the present invention is a one-part tooth surface treatment material characterized by containing complex ions (A) of silver ions and iodide ions (A) and water.
  • the upper limit value and the lower limit value of the numerical range can be appropriately combined.
  • silver ions have a bactericidal power against bacteria, they are widely used as antibacterial agents, and are also applied as dental agents for the purpose of controlling caries.
  • silver-based dental agents that have been used in the past produce silver (I) oxide (Ag 2 O) in the air, and the treated area turns black.
  • a liquid containing a silver compound (first liquid) a liquid containing a halogenated alkali metal or an alkaline earth metal halide (second liquid) is applied.
  • coating and chemically removing the silver compound which exists excessively in an affected part is also used, it is a two-material type
  • mold and operation is complicated (refer patent document 1).
  • the present inventors have developed a tooth surface treatment material that is easy to handle with a single material type, suppresses the progression of caries without impairing the aesthetic surface of the treatment site, and suppresses hypersensitivity.
  • the one-surface type tooth surface treatment material of the present invention is easy to handle and can suppress the progression of caries without impairing the aesthetic surface of the treatment site.
  • silver oxide (I) Ag 2 O
  • silver iodide (AgI) which does not easily turn black in the air
  • the silver compound needs to be present in a state of silver ions in the tooth surface treatment material, but silver iodide is hardly dissolved in water.
  • silver iodide in an aqueous solution containing an iodide salt (B), silver iodide can be dissolved and exist as a complex ion (A) of silver ions and iodide ions.
  • A complex ion
  • iodide salt B
  • excess silver compound is removed to obtain the effect
  • the silver compound is iodine in the form of an aqueous solution containing an iodide salt (B).
  • a caries inhibitory effect is obtained by making it exist as a complex ion (A) of silver ions and iodide ions.
  • the one-surface type tooth surface treatment material of the present invention silver is present in an ionic state in advance, and it can be easily distributed to places where the applicator such as the adjacent surface of the tooth is difficult to reach. . Thereby, an excellent caries-suppressing effect is expected in any affected part. Further, the complex ion (A) of silver ions and iodide ions that have penetrated into the affected area is precipitated as silver iodide in the tooth, and therefore the treated area does not turn black. Furthermore, since the solution containing the complex ion (A) of silver ions and iodide ions is stable without blackening or re-precipitation, it can be easily stored and handled as a one-material type. Further, the one-surface type tooth surface treatment material of the present invention has acid resistance necessary in the oral cavity.
  • silver ion and iodide are dissolved by dissolving silver iodide itself in an aqueous solution containing iodide salt (B) as described above.
  • iodide salt (B) iodide salt
  • the Ag—I bond has a strong covalent bond, and therefore, a stable complex ion of silver ion and iodide ion. (A) is considered to be generated.
  • the one-surface type tooth surface treatment material of the present invention is a one-material type, is easy to handle, and can suppress hypersensitivity without impairing the aesthetic surface of the treatment site.
  • the tooth surface treatment material penetrates into the dentinal tubule, it comes into contact with the tissue fluid present in the dentinal tubule.
  • Silver ions are particularly reactive with thiol groups of proteins that make up tissue fluids.
  • the protein is denatured, the viscosity of the tissue fluid in the dentinal tubule increases, and the movement of the tissue fluid in the dentinal tubule is suppressed, so that it is considered that hypersensitivity is suppressed.
  • the one-surface type tooth surface treatment material of the present invention is for suppressing hypersensitivity
  • the dentinal tubule sealing rate is high.
  • the concentration of silver atoms present in a solution in the solution is preferably 500 to 125,000 ppm by mass, preferably 2,000 to 125,000, based on the mass of the one-surface type tooth surface treatment material. 000 ppm by mass is more preferable, and 10,000 to 125,000 ppm by mass is more preferable.
  • the tooth surface treatment material of one material type of the present invention contains complex ions (A) of silver ions and iodide ions (A) and water, but the concentration of silver atoms present in the solution in the solution state is that of one material type. It is preferably 10 to 125,000 mass ppm with respect to the mass of the tooth surface treatment material. When the silver atom concentration is less than 10 ppm by mass, the caries-suppressing effect when the tooth surface treatment material is applied is considerably smaller than that of a commercially available caries-suppressing material (for example, saholide).
  • the silver atom concentration is preferably 1000 ppm by mass or more, and more preferably 10,000 ppm by mass or more.
  • the concentration exceeds 125,000 ppm by mass, the antibacterial effect does not change even when the concentration is higher than that. Since silver compounds are generally expensive, there is no merit in terms of cost. Further, the complex ion (A) of silver ions and iodide ions cannot be completely dissolved and silver iodide may be precipitated.
  • the silver atom concentration is more preferably 120,000 mass ppm or less. The calculation method of the silver atom concentration is as in the examples described later.
  • silver salt (C) is a certain embodiment ("1st embodiment").
  • silver diammine fluoride (Ag (NH 3 ) 2 F) silver nitrate (I), silver fluoride (I), silver chloride (I), silver bromide (I), silver carbonate (I) , Silver iodide (I), silver oxide (I), silver chlorate (I), silver perchlorate (I), silver chromate (I), silver hexafluoroantimonate (V), silver hexafluorophosphate
  • At least one selected from the group consisting of (I), silver nitrite (I), silver sulfate (I), silver thiocyanate (I), silver vanadate (AgVO 3 ), and organic silver salt is preferably used.
  • silver iodide (I) is more preferable because it easily increases the silver concentration in the solution.
  • the silver salt (C) used in the tooth surface treatment material of the present invention is a suitable compound in the first embodiment
  • the molar ratio of iodide salt (B) / silver salt (C) is: It is preferable that the silver salt (C) is not less than a lower limit value at which the silver salt (C) is completely dissolved in the one-material type tooth surface treatment material.
  • silver iodide (I) and organic silver salts are not limited as described later.
  • the “lower limit value for complete dissolution” means the lower limit value of the molar ratio of iodide salt (B) / silver salt (C) in which the silver salt (C) is visually dissolved.
  • the lower limit value for completely dissolving the salt (C) is that the molar ratio of iodide salt (B) / silver salt (C) is 3.5. That is, as the tooth surface treatment material of one material type of the first embodiment, in the case of AgX type, the molar ratio of iodide salt (B) / silver salt (C) is preferably 3.5 or more.
  • the molar ratio of iodide salt (B) / silver salt (C) is preferably 1.9 or more.
  • the lower limit value for completely dissolving the silver salt (C) is that the molar ratio of iodide salt (B) / silver salt (C) is 7.5.
  • the one-type tooth surface treatment material of the first embodiment preferably has an iodide salt (B) / silver salt (C) molar ratio of 7.5 or more.
  • the lower limit value for completely dissolving the silver salt (C) is 10 in the molar ratio of iodide salt (B) / silver salt (C). That is, in the case of the Ag 3 X type, the one-type tooth surface treatment material of the first embodiment preferably has an iodide salt (B) / silver salt (C) molar ratio of 10 or more.
  • the molar ratio of iodide salt (B) / silver salt (C) is less than the lower limit for each type of silver salt (C), undissolved silver salt (C) is present in the tooth surface treatment material. . For this reason, depending on the type of the silver salt (C), when the tooth surface treatment material is applied, the undissolved silver salt (C) may be oxidized and blackened.
  • the silver salt (C) used in the one-surface type tooth surface treatment material of the present invention is silver iodide (I) and an organic silver salt which are not easily blackened
  • the iodide salt (B) The molar ratio of / silver salt (C) may be less than the lower limit value at which the silver salt (C) is completely dissolved in the one-surface type tooth surface treatment material. Therefore, as another embodiment (also referred to as “second embodiment”), the silver salt (C) is at least one silver compound selected from the group consisting of silver iodide (I) and organic silver salt.
  • the molar ratio of iodide salt (B) / silver salt (C) is less than the lower limit value at which the silver salt (C) is completely dissolved.
  • undissolved silver salt (C) is present in the tooth surface treatment material, when the tooth surface treatment material is applied, the silver salt (C) is silver iodide (I) or an organic silver salt.
  • the tooth surface treatment material of one material type of the second embodiment is also difficult to turn black.
  • silver formate (I), silver citrate (I), silver oxalate (II), silver propionate (I), silver succinate (I), 2-ethyl Silver hexanoate (I), silver lactate (I), silver salicylate (I), and silver N, N-diethyldithiocarbamate (I) are more preferred.
  • the iodide ion used in the present invention is derived from the iodide salt (B) and is not particularly limited, but the iodide salt (B) is sodium iodide, potassium iodide, rubidium iodide, magnesium iodide, At least one selected from the group consisting of calcium iodide and strontium iodide is preferably used. Among these, sodium iodide and potassium iodide are more preferable from the viewpoint of the solubility of the silver salt (C).
  • the tooth surface treatment material of one material type of the present invention produces silver (I) in the inside and surface of the tooth when water is evaporated after being applied to the tooth, etc., and more than 24 hours have passed after the treatment. Will not turn black.
  • the degree of blackening was quantified by the method described in the examples.
  • the value obtained by subtracting the L value after applying the tooth surface treatment material from the L value before applying the tooth surface treatment material, that is, the color difference ( ⁇ L *) before and after application of the tooth surface treatment material is 20 or less. Is preferred. It is preferably 15 or less, more preferably 10 or less.
  • the method of measuring the color difference is as described in the examples described later.
  • the one-surface type tooth surface treatment material of the present invention preferably further contains a water-soluble fluoride salt (D) from the viewpoint of acid resistance.
  • a water-soluble fluoride salt (D) Sodium fluoride, potassium fluoride, ammonium fluoride, lithium fluoride, cesium fluoride, magnesium fluoride, calcium fluoride, strontium fluoride, barium fluoride , Copper fluoride, zirconium fluoride, aluminum fluoride, tin fluoride, sodium monofluorophosphate, potassium monofluorophosphate, hydrofluoric acid, sodium titanium fluoride, potassium titanium fluoride, hexylamine hydrofluoride, Examples include laurylamine hydrofluoride, glycine hydrofluoride, alanine hydrofluoride, and fluorosilanes. Of these, sodium fluoride, potassium fluoride, sodium monofluorophosphate, and tin fluoride are preferably used from the viewpoint of safety to
  • the concentration of the water-soluble fluoride salt (D) is preferably 0.01 to 5.0% as a converted fluorine ion concentration. If the concentration is less than 0.01%, the acid resistance of the tooth substance to which the tooth surface treatment material is applied may not be improved. The concentration is more preferably 0.02% or more. On the other hand, when the concentration exceeds 5.0%, safety to the living body may be impaired. The concentration of the water-soluble fluoride salt (D) is more preferably 4.5% or less.
  • mold of this invention is not specifically limited,
  • iodide salt (B) the method of mixing silver salt (C) and water, and dissolving
  • iodide salt (B) Silver ion and iodide can be dissolved by adding silver salt (C) to a solution of water and water; by adding iodide salt (B) to a mixed solution of silver salt (C) and water and dissolving.
  • the means for dissolving the components after mixing them is not particularly limited, but can be achieved by methods such as stirring dissolution using a stirring blade, vibration dissolution, ultrasonic dissolution, rotation and revolution stirring stirring and dissolution.
  • a method of adding silver salt (C) to a solution of iodide salt (B) and water and dissolving it, iodide salt for example, a method of adding silver salt (C) to a solution of iodide salt (B) and water and dissolving it, iodide salt ( An aqueous iodide solution having a B) concentration of 5 to 60% by mass and a silver salt (C) are mixed so that the molar ratio of iodide salt (B) / silver salt (C) is 0.5 or more. It is preferable to include a generation step of the complex ion (A) to be made.
  • the concentration of the iodide salt (B) is preferably 10% by mass or more, and more preferably 20% by mass or more, from the viewpoint of the solubility of the silver salt (C). On the other hand, when it exceeds 60% by mass, the iodide salt (B) is in an undissolved state, and therefore it is preferably 55% by mass or less.
  • the molar ratio of iodide salt (B) / silver salt (C) is preferably 1.0 or more, more preferably 2.0 or more, from the viewpoint of solubility of the silver salt (C). is there.
  • the tooth surface treatment material of one material type of the present invention is a complex ion (A) of silver ion and iodide ion, iodide salt (B), silver salt (C), water-soluble within a range not inhibiting the effects of the present invention.
  • Fluoride salt (D) and other components other than water may be contained.
  • flavor, etc. can be mix
  • the content of other components is not particularly limited, but is preferably less than 10% by mass, more preferably less than 5% by mass, and even more preferably less than 1% by mass in a single-tooth type tooth surface treatment material.
  • the thickening agent is not particularly limited, and fine particle silica, carboxymethylcellulose, sodium carboxymethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, polyvinyl alcohol, polyacrylic acid, polystyrene sulfonic acid, polystyrene sulfonate, polyglutamic acid, polyglutamic acid.
  • the solvent is not particularly limited, but water-soluble tetrahydrofuran, 1,4-dioxane, ethanol, methanol, 1-propanol, isopropyl alcohol, Tert-butyl alcohol, ethylene glycol, glycerin, acetone, 1,2-dimethoxyethane, Examples include acetonitrile and dimethylformamide. Among these, ethanol, 1-propanol, acetone, and glycerin that are highly safe for living bodies are preferable.
  • sugar alcohols such as xylitol, sorbitol and erythritol
  • artificial sweeteners such as aspartame, acesulfame potassium, licorice extract, saccharin and saccharin sodium may be added.
  • any pharmacologically acceptable drug or the like can be blended.
  • Antibacterial agents typified by cetylpyridinium chloride, etc .; antiseptics; anticancer agents; antibiotics; blood circulation improving agents such as actosine and PGE1; growth factors such as bFGF, PDGF and BMP; osteoblasts; odontoblasts; Bone marrow-derived stem cells; embryonic stem (ES) cells; induced pluripotent stem (iPS) cells obtained by dedifferentiation and production of differentiated cells such as fibroblasts by gene transfer, and cells such as differentiated cells Cells or the like that promote tissue formation can be added.
  • antiseptics typified by cetylpyridinium chloride, etc .
  • anticancer agents such as antibiotics
  • blood circulation improving agents such as actosine and PGE1
  • growth factors such as bFGF, PDGF and BMP
  • osteoblasts odontoblasts
  • Bone marrow-derived stem cells embryonic stem (ES) cells
  • ES embryonic stem
  • the one-surface type tooth surface treatment material of the present invention is obtained as a solution containing at least silver ions and iodide complex ions (A) and water, has excellent operability, and suppresses caries progression and hypersensitivity. It is possible and aesthetic treatment is possible because the affected area does not turn black. In addition, there is no ammonia smell, no irritation to gingiva, and excellent usability. Furthermore, the one-surface type tooth surface treatment material of the present invention can be stably stored as a single-material type, and is excellent in storage stability. In addition, the one-surface type tooth surface treatment material of the present invention is excellent in acid resistance required in the oral cavity.
  • the present invention includes embodiments in which the above configurations are combined in various ways within the technical scope of the present invention as long as the effects of the present invention are exhibited.
  • Potassium iodide Wako Pure Chemical Industries, Ltd. product was used as it was.
  • Sodium iodide Wako Pure Chemical Industries, Ltd. product was used as it was.
  • Silver bromide (I): Wako Pure Chemical Industries, Ltd. product was used as it was.
  • Example 1 3.65 g of potassium iodide was added to 3.65 g of water and dissolved by stirring to prepare a 50% by mass potassium iodide aqueous solution. To this solution was further added 2.7 g of silver (I) iodide and dissolved by stirring at room temperature to obtain a tooth surface treatment material containing a complex ion (A) of colorless and transparent silver ions and iodide ions. This material is a one-material type.
  • Example 2 3.8 g of potassium iodide was added to 3.8 g of water and dissolved by stirring to prepare a 50% by mass potassium iodide aqueous solution. Further, 2.4 g of silver (I) iodide was added to this solution and dissolved by stirring at room temperature to obtain a tooth surface treatment material containing a complex ion (A) of colorless and transparent silver ions and iodide ions. This material is a one-material type.
  • Example 3 4.88 g of potassium iodide was added to 4.88 g of water and dissolved by stirring to prepare a 50 mass% potassium iodide aqueous solution. To this solution was further added 0.24 g of silver (I) and dissolved by stirring at room temperature to obtain a tooth surface treatment material containing a complex ion (A) of colorless and transparent silver ions and iodide ions. This material is a one-material type.
  • Example 4 4.988 g of potassium iodide was added to 4.988 g of water and dissolved by stirring to prepare a 50 mass% potassium iodide aqueous solution. To this solution, 0.024 g of silver iodide (I) was further added and dissolved by stirring at room temperature to obtain a tooth surface treatment material containing complex ions (A) of colorless and transparent silver ions and iodide ions. This material is a one-material type.
  • Example 5 4.998 g of potassium iodide was added to 4.998 g of water and dissolved by stirring to prepare a 50 mass% potassium iodide aqueous solution. To this solution was further added 0.004 g of silver (I) and dissolved by stirring at room temperature to obtain a tooth surface treating material containing a complex ion (A) of colorless and transparent silver ions and iodide ions. This material is a one-material type.
  • Example 6 3.14 g of potassium iodide was added to 5.82 g of water and dissolved by stirring to prepare a 35 mass% potassium iodide aqueous solution. To this solution, 1.04 g of silver iodide (I) was further added and dissolved by stirring at room temperature to obtain a tooth surface treatment material containing complex ions (A) of colorless and transparent silver ions and iodide ions. This material is a one-material type.
  • Example 7 2.3 g of potassium iodide was added to 6.88 g of water and dissolved by stirring to prepare a 25 mass% potassium iodide aqueous solution. To this solution, 0.82 g of silver (I) was further added and dissolved by stirring at room temperature to obtain a tooth surface treatment material containing a complex ion (A) of colorless and transparent silver ions and iodide ions. This material is a one-material type.
  • Example 8 1.49 g of potassium iodide was added to 8.462 g of water and dissolved by stirring to prepare a 15% by mass potassium iodide aqueous solution. To this solution, 0.048 g of silver iodide (I) was further added and dissolved by stirring at room temperature to obtain a tooth surface treatment material containing a complex ion (A) of colorless and transparent silver ions and iodide ions. This material is a one-material type.
  • Example 9 0.7 g of potassium iodide was added to 9.29 g of water and dissolved by stirring to prepare a 7% by mass potassium iodide aqueous solution. To this solution, 0.01 g of silver iodide (I) was further added and dissolved by stirring at room temperature to obtain a tooth surface treatment material containing a complex ion (A) of colorless and transparent silver ions and iodide ions. This material is a one-material type.
  • Example 10 A 58 mass% potassium iodide aqueous solution was prepared by adding 4.23 g of potassium iodide to 3.07 g of water and dissolving with stirring. To this solution was further added 2.7 g of silver (I) iodide and dissolved by stirring at room temperature to obtain a tooth surface treatment material containing a complex ion (A) of colorless and transparent silver ions and iodide ions. This material is a one-material type.
  • Example 11 3.8 g of sodium iodide was added to 3.8 g of water and dissolved by stirring to prepare a 50 mass% sodium iodide aqueous solution. Further, 2.4 g of silver (I) iodide was added to this solution and dissolved by stirring at room temperature to obtain a tooth surface treatment material containing a complex ion (A) of colorless and transparent silver ions and iodide ions. This material is a one-material type.
  • Example 12 4.55 g of potassium iodide was added to 4.55 g of water and dissolved by stirring to prepare a 50% by mass aqueous potassium iodide solution. To this solution was further added 0.9 g of silver fluoride (I), and the mixture was stirred and dissolved at room temperature to obtain a tooth surface treatment material containing a complex ion (A) of colorless and transparent silver ions and iodide ions. This material is a one-material type.
  • Example 13 Potassium iodide (4.31 g) was added to water (4.31 g) and dissolved by stirring to prepare a 50 mass% potassium iodide aqueous solution. Further, 1.38 g of silver (I) bromide was added to this solution and dissolved by stirring at room temperature to obtain a tooth surface treatment material containing a complex ion (A) of colorless and transparent silver ions and iodide ions. This material is a one-material type.
  • Example 14 4.61 g of potassium iodide was added to 4.61 g of water and dissolved by stirring to prepare a 50 mass% potassium iodide aqueous solution. To this solution, 0.78 g of silver oxide (I) was further added and dissolved by stirring at room temperature to obtain a tooth surface treatment material containing a complex ion (A) of colorless and transparent silver ions and iodide ions. This material is a one-material type.
  • Example 15 4.36 g of potassium iodide was added to 4.36 g of water and dissolved by stirring to prepare a 50 mass% aqueous potassium iodide solution. Further, 1.28 g of silver (I) citrate was added to this solution and dissolved by stirring at room temperature to obtain a tooth surface treatment material containing a complex ion (A) of colorless and transparent silver ions and iodide ions. This material is a one-material type.
  • Example 16 Potassium iodide (4.13 g) was added to water (4.13 g) and dissolved by stirring to prepare a 50 mass% potassium iodide aqueous solution. Further, 1.74 g of silver 2-ethylhexanoate (I) was added to this solution and dissolved by stirring at room temperature to obtain a tooth surface treatment material containing a complex ion (A) of colorless and transparent silver ions and iodide ions. Obtained. This material is a one-material type.
  • Example 17 Potassium iodide (3.5 g) was added to water (3.5 g) and dissolved by stirring to prepare a 50 mass% potassium iodide aqueous solution.
  • This material is a one-material type.
  • Example 18 Potassium iodide (3.5 g) was added to water (3.5 g) and dissolved by stirring to prepare a 50 mass% potassium iodide aqueous solution. To this solution, 2.4 g of silver iodide (I) and 0.6 g of potassium fluoride were further added and dissolved by stirring at room temperature, whereby teeth containing complex ions (A) of colorless and transparent silver ions and iodide ions were obtained. A surface treatment material was obtained. This material is a one-material type.
  • Example 19 2.71 g of potassium iodide was added to 5.04 g of water and dissolved by stirring to prepare a 35 mass% aqueous potassium iodide solution. To this solution, 0.9 g of silver iodide (I) and 1.35 g of potassium fluoride were further added and dissolved by stirring at room temperature, whereby a tooth containing complex ions (A) of colorless and transparent silver ions and iodide ions was obtained. A surface treatment material was obtained. This material is a one-material type.
  • liquid A a sulphonide was used as an aqueous solution containing 38% by mass of silver diammine fluoride.
  • solution B 4.0 g of potassium iodide was added to 6.0 g of water and dissolved by stirring. This material is a two-material type. In the case of using for the test, first, the liquid A was applied, washed with water and dried, and then the liquid B was applied, washed with water and dried.
  • the inhibition circle width is calculated from the bottom side of the petri dish based on the following for the inhibition circle formed around the paper disk.
  • W (TD) / 2 Where W represents the width (mm) of the blocking circle (halo), T represents the sum of the length of the paper disk and the width of the blocking circle (mm), and D represents the length of the paper disk (mm). .)
  • Examples 1 to 19 By the procedure shown above, antibacterial activity, discoloration, acid resistance, storage stability, and precipitates upon addition of water were evaluated. The obtained evaluation results are shown in Tables 1 to 4. In addition, the precipitation at the time of water addition was performed only about Example 2 and 15.
  • FIGS. 1 and 2 show analysis charts obtained by performing X-ray diffraction analysis on the precipitates obtained by adding the same amount of water to the tooth surface treatment materials obtained in Examples 2 and 15 and precipitating them.
  • the main component of the precipitate was silver (I) iodide, which was confirmed to be a mixture of two types of crystal structures, hexagonal and cubic.
  • the single-surface tooth surface treatment material of the present invention is easy to handle and is useful for suppressing the progression of caries and hypersensitivity without impairing the aesthetic surface of the treatment site.
  • the one-surface type tooth surface treatment material of the present invention does not have an ammonia odor, has an excellent feeling of use, and can be suitably used as a caries progress inhibitor, a hypersensitivity inhibitor, or the like.
  • the one-surface type tooth surface treatment material of the present invention is excellent in acid resistance and storage stability.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Birds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dental Preparations (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne un matériau de traitement de surface dentaire de type à un seul matériau, facile à manipuler, qui supprime l'hyperesthésie ou enraye la progression de la carie dentaire sans endommager l'esthétique de surface du site traité. L'invention concerne le matériau de traitement de surface dentaire de type à un seul matériau, qui contient de l'eau et un ion complexe (A) d'un ion iodure et d'un ion argent.
PCT/JP2017/041505 2016-11-18 2017-11-17 Matériau de traitement de surface dentaire de type à un seul matériau WO2018092889A1 (fr)

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WO2020021495A1 (fr) * 2018-07-27 2020-01-30 3M Innovative Properties Company Compositions aqueuses contenant du thiocyanate pour soins buccodentaires, procédés et kits
WO2020044230A1 (fr) * 2018-08-28 2020-03-05 3M Innovative Properties Company Solutions aqueuses de soin buccal, procédés, kits et surfaces dentaires comportant un revêtement dérivé de la solution de soin buccal
WO2021137152A1 (fr) * 2019-12-31 2021-07-08 3M Innovative Properties Company Composition de soin buccal durcissable contenant de l'argent et du fluorure
JP2021107371A (ja) * 2019-12-27 2021-07-29 クラレノリタケデンタル株式会社 一材型の歯面処理材
WO2021152505A1 (fr) * 2020-01-30 2021-08-05 3M Innovative Properties Company Article et procédé pour traiter des caries dentaires interproximales
US11897083B2 (en) 2018-10-25 2024-02-13 3M Innovative Properties Company Robotic paint repair systems and methods

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US11666516B2 (en) 2018-07-27 2023-06-06 3M Innovative Properties Company Aqueous oral care thiocyanate-containing compositions, methods, and kits
CN112512485A (zh) * 2018-07-27 2021-03-16 3M创新有限公司 含硫氰酸盐的口腔护理水性组合物、方法和试剂盒
JP2021533097A (ja) * 2018-07-27 2021-12-02 スリーエム イノベイティブ プロパティズ カンパニー 水性口腔ケアヨウ化物含有組成物、方法、及びキット
AU2019309736B2 (en) * 2018-07-27 2022-05-12 Solventum Intellectual Properties Company Aqueous oral care iodide-containing compositions, methods, and kits
US11793734B2 (en) 2018-07-27 2023-10-24 3M Innovative Properties Company Aqueous oral care iodide-containing compositions, methods, and kits
WO2020021495A1 (fr) * 2018-07-27 2020-01-30 3M Innovative Properties Company Compositions aqueuses contenant du thiocyanate pour soins buccodentaires, procédés et kits
WO2020021494A1 (fr) * 2018-07-27 2020-01-30 3M Innovative Properties Company Compositions aqueuses contenant de l'iodure pour des soins buccaux, procédés et trousses
JP7407792B2 (ja) 2018-07-27 2024-01-04 スリーエム イノベイティブ プロパティズ カンパニー 水性口腔ケアチオシアネート含有組成物、方法、及びキット
JP7407791B2 (ja) 2018-07-27 2024-01-04 スリーエム イノベイティブ プロパティズ カンパニー 水性口腔ケアヨウ化物含有組成物、方法、及びキット
JP2021531318A (ja) * 2018-07-27 2021-11-18 スリーエム イノベイティブ プロパティズ カンパニー 水性口腔ケアチオシアネート含有組成物、方法、及びキット
US11318005B2 (en) 2018-08-28 2022-05-03 3M Innovative Properties Company Aqueous oral care solutions, methods, kits, and tooth surfaces having a coating derived from the oral care solution
CN113038921A (zh) * 2018-08-28 2021-06-25 3M创新有限公司 水性口腔护理溶液、方法、试剂盒和具有来源于口腔护理溶液的涂层的牙齿表面
WO2020044230A1 (fr) * 2018-08-28 2020-03-05 3M Innovative Properties Company Solutions aqueuses de soin buccal, procédés, kits et surfaces dentaires comportant un revêtement dérivé de la solution de soin buccal
JP7115722B2 (ja) 2018-08-28 2022-08-09 スリーエム イノベイティブ プロパティズ カンパニー 水性口腔ケア溶液、方法、キット、及び該口腔ケア溶液から誘導されたコーティングを有する歯表面
JP2021525794A (ja) * 2018-08-28 2021-09-27 スリーエム イノベイティブ プロパティズ カンパニー 水性口腔ケア溶液、方法、キット、及び該口腔ケア溶液から誘導されたコーティングを有する歯表面
US11897083B2 (en) 2018-10-25 2024-02-13 3M Innovative Properties Company Robotic paint repair systems and methods
JP2021107371A (ja) * 2019-12-27 2021-07-29 クラレノリタケデンタル株式会社 一材型の歯面処理材
JP7316929B2 (ja) 2019-12-27 2023-07-28 クラレノリタケデンタル株式会社 一材型の歯面処理材
CN114929177A (zh) * 2019-12-31 2022-08-19 3M创新有限公司 含有银和氟化物的可固化口腔护理组合物
WO2021137152A1 (fr) * 2019-12-31 2021-07-08 3M Innovative Properties Company Composition de soin buccal durcissable contenant de l'argent et du fluorure
WO2021152505A1 (fr) * 2020-01-30 2021-08-05 3M Innovative Properties Company Article et procédé pour traiter des caries dentaires interproximales

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