WO2018068684A1 - 一种密封装置 - Google Patents

一种密封装置 Download PDF

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Publication number
WO2018068684A1
WO2018068684A1 PCT/CN2017/105280 CN2017105280W WO2018068684A1 WO 2018068684 A1 WO2018068684 A1 WO 2018068684A1 CN 2017105280 W CN2017105280 W CN 2017105280W WO 2018068684 A1 WO2018068684 A1 WO 2018068684A1
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light
shielded
infusion
substance
intended
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PCT/CN2017/105280
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English (en)
French (fr)
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胡绍勤
汤丽芬
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胡绍勤
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D33/00—Details of, or accessories for, sacks or bags
    • B65D33/16—End- or aperture-closing arrangements or devices

Definitions

  • the present invention relates to the field of medical packaging materials, and in particular to a sealing device.
  • a light-shielding material In daily life, it is often necessary to apply a light-shielding material to separate storage, infusion therapy, and transport of some special materials (such as photo-decomposable drugs, reagents, preparations, and materials). Clinically, some drugs have poor stability. When dissolved, they are prone to oxidation, decomposition, discoloration, etc.; some chemotherapeutic drugs can undergo complex reactions such as splitting, rearrangement, hydrolysis, polymerization, oxidation, and isomerization. Light can catalyze the progress of the above reaction. However, when the light-shielding material is in direct contact with the light-decomposable substance, it often affects the physical and chemical properties of the drug or material or other chemical reactions.
  • the present invention provides a sealing device which is good in light protection and can be used safely.
  • a sealing device comprising a body provided with a separable space; the separable space is partitioned into a first partition space and a second partition space by a body; the outer side of the body is covered with a light-proof material and/or the body is protected from light Material; the sealing device is between the light-shielding materials
  • the gap is provided with a shutter that blocks at least one side of the gap and exceeds the length of the gap.
  • the light-shielding material and the light-decomposable substance that is expected to be shielded are separated by at least one layer of separation material, and the separation material is not in contact with the light-decomposable substance that is expected to be shielded; Or the light-shielding material and the light-decomposable substance that is expected to be shielded are separated by at least one layer of separation material, and the light-decomposable substance that is expected to be shielded is not in contact with the separation material, and the physical and chemical properties are not changed; or the light-proof material is expected to be
  • the masked light-decomposable materials are separated by at least one layer of a separating material that is in contact with the light-decomposable material that is intended to be shielded from each other without physical and chemical properties being altered.
  • At least a layer of colorless and transparent polymer material is interposed between the light-proof material and the light-decomposable substance that is expected to be shielded.
  • the body is disposed around the outer periphery of the light-decomposable substance that is intended to be shielded; or the body is disposed around the light-decomposable substance that is intended to be shielded; or the body is disposed on two light sources that are intended to be shielded.
  • the body Decomposing between the substances; or the body is disposed between the non-photodecomposable substance and the light-decomposable substance that is intended to be shielded; or the body is disposed on the container opening of the peripheral device for storing the light-decomposable substance that is intended to be shielded;
  • the body is disposed on a liquid flow path of a liquid containing a photodecomposable substance, and the body is provided with a connection port communicating with the liquid flow path.
  • the shutter is formed by folding and/or extending from a light-shielding material.
  • the light-proof material is made of a light-proof film.
  • An infusion device comprising any of the above described sealing devices.
  • the infusion device is selected from the group consisting of an infusion line, an infusion set, an indwelling needle, an infusion needle, an infusion extension tube, a syringe, an infusion connector, an infusion connection tube, a drip bucket, and a filter.
  • a storage device comprising any of the above sealing devices.
  • the storage device is selected from the group consisting of an infusion bottle, an infusion bag, an ampoule, a medicine bottle, a reagent bottle, a medicine box, and a storage box.
  • the invention has the beneficial effects that the sealing device solves the expected light-decomposable substance by shielding at least between a light-proof material and a light-decomposable substance that is intended to be shielded with at least one layer of colorless transparent polymer material or other type of separating material.
  • the material in contact with it reacts, causing the problem of the physical and chemical properties of the light-decomposable substance to change, ensuring the stability of the light-decomposable substance.
  • FIG. 1 is a schematic view showing the overall structure of a first embodiment of the present invention
  • Figure 2 is a schematic view showing the overall structure of a second embodiment of the present invention.
  • Figure 3 is a schematic view showing the overall structure of a third embodiment of the present invention.
  • Figure 4 is a schematic view showing the overall structure of a fourth embodiment of the present invention.
  • a sealing device includes a body provided with a separable space 15 1; the separable space 15 is partitioned into a first partition space 16 and a second partition space 17 by the body 1; the outer side of the body 1 covers the light-proof material 4 and/or the body 1 is sandwiched with a light-shielding material 4;
  • the sealing device is provided with a shutter 43 that blocks at least one side of the gap and exceeds the gap pitch length in a gap between the light shielding materials 4.
  • the first partition space 16 and the second partition space 17 may be two independent sealed partition spaces; or one of them may be an independent closed partition space, and the other may be an open partition space; or one of them may be The other space is connected to the closed partition space, and the other is the open partition space; or one of them may be a closed partition space that communicates with other spaces, and the other is a separate closed partition space.
  • At least a layer of partitioning material 42 is interposed between the light-shielding material 4 and the light-decomposable substance that is intended to be shielded, and the partitioning material 42 is in contact with the light-decomposable substance that is intended to be shielded from physical and chemical properties.
  • At least a layer of separating material 42 is interposed between the light-shielding material 4 and the light-decomposable substance that is intended to be shielded, and the photo-decomposable substance that is expected to be shielded is not in contact with the partitioning material 42; At least a layer of separating material 42 is interposed between the light-shielding material 4 and the light-decomposable substance that is intended to be shielded, and the partitioning material 42 is in contact with the light-decomposable substance that is expected to be shielded without undergoing physical and chemical properties change from each other.
  • At least a layer of colorless and transparent polymer material 420 is interposed between the light-protecting material 4 and the light-decomposable substance that is intended to be shielded.
  • the body is provided as part or all of the partitioning material, of course, the body and The separator materials may also be arranged independently of each other.
  • the partition material is a colorless and transparent polymer material.
  • At least one layer of separation material between the light-shielding material and the light-decomposable substance that is expected to be shielded, at least a layer of colorless and transparent polymer material may be interposed between the light-proof material and the light-decomposable substance that is expected to be shielded.
  • Photodegradable materials that are expected to be masked include drugs, reagents, formulations, materials, and other materials that have photodegradable properties.
  • the body 1 is disposed around the outer periphery of the light-decomposable substance that is intended to be shielded; or the body 1 is disposed around the light-decomposable substance that is intended to be shielded; or the body 1 is disposed in two intended shielding Between the light-decomposable substances; or the body 1 is disposed between the non-photodecomposable substance and the light-decomposable substance that is intended to be shielded; or the body 1 is disposed at a peripheral of the container for storing the light-decomposable substance that is intended to be shielded Or the body 1 is disposed on a liquid flow path of a liquid containing a photodecomposable substance, and the body 1 is provided with a connection port communicating with the liquid flow path.
  • the shutter 43 is formed by folding and/or extending from the light-proof material 4.
  • the light shielding material 4 is made of a light shielding film 41. Made out.
  • the light-shielding material can also be made of other materials such as aluminum foil, light-shielding paper, shading cloth, and opaque material.
  • the light-shielding material may be provided with one layer or two or more layers. When two or more layers of materials are used, different materials and types of light-shielding materials may be used.
  • an infusion set includes any of the above described sealing means.
  • the infusion device is selected from the group consisting of an infusion line, an infusion set, an indwelling needle, an infusion needle, an infusion extension tube, a syringe, an infusion connector, an infusion connection tube, a drip chamber, and a filter.
  • a storage device includes any of the above described sealing devices.
  • the storage device is selected from the group consisting of an infusion bottle, an infusion bag, an ampoule, a vial, a reagent bottle, a drug box, and a storage box.

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Packages (AREA)

Abstract

一种密封装置，包括设有可分隔空间(15)的本体(1)；所述可分隔空间(15)通过本体(1)分隔成第一分隔空间(16)和第二分隔空间(17)；所述本体(1)外侧覆盖避光材料(4)和/或者本体(1)上夹有避光材料(4)；所述密封装置在避光材料(4)之间的间隙上设有至少遮挡在上述间隙的一侧且超过上述间隙间距长度的遮蔽器(43)。通过在避光材料(4)与预期遮蔽的光易分解物质之间至少隔有一层分隔材料(42)，解决预期遮蔽的光易分解物质与其接触的材料出现反应，从而导致光易分解物质出现理化性质改变的问题，确保光易分解物质的稳定性。通过在避光材料(4)之间的间隙上设置遮蔽器(43)，解决光线从缝隙间进入，导致光易分解物质见光分解的问题，保持避光性能良好。密封装置用于医用包装材料领域。

Description

一种密封装置 技术领域
本发明涉及医用包装材料领域，特别是涉及一种密封装置。
背景技术
日常生活中经常需要应用避光材料对一些特殊物料(如光易分解药物、试剂、配剂和物料等)进行分隔储存、输注治疗和转运等。临床上一些药物的稳定性差，溶解后遇光易发生氧化、分解、变色等反应；一些化疗药物溶解后可发生裂环、重排、水解、聚合、氧化、异构化等较复杂的反应，光照可催化上述反应的进程。但避光材料与光易分解物质直接接触时，往往会影响药物或物料的理化性质或者发生其它化学反应。
现行避光用品在避光材料间会出现缝隙，导致光线可从缝隙间进入避光用品内部，进而避光性能下降。
临床需要一种避光性能好和可以安全使用的密封装置。
发明内容
为解决上述问题，本发明提供一种避光性能好和可以安全使用的密封装置。
本发明解决其技术问题所采用的技术方案是：
一种密封装置，包括设有可分隔空间的本体；所述可分隔空间通过本体分隔成第一分隔空间和第二分隔空间；所述本体外侧覆盖避光材料和/或者本体上夹有避光材料；所述密封装置在避光材料之间的 间隙上设有至少遮挡在上述间隙的一侧且超过上述间隙间距长度的遮蔽器。
进一步作为本发明技术方案的改进，所述避光材料与预期遮蔽的光易分解物质之间至少隔有一层分隔材料，所述分隔材料与预期遮蔽的光易分解物质接触不发生理化性质改变；或者所述避光材料与预期遮蔽的光易分解物质之间至少隔有一层分隔材料，预期遮蔽的光易分解物质与所述分隔材料接触不发生理化性质改变；或者所述避光材料与预期遮蔽的光易分解物质之间至少隔有一层分隔材料，所述分隔材料与预期遮蔽的光易分解物质接触而彼此不发生理化性质改变。
进一步作为本发明技术方案的改进，所述避光材料与预期遮蔽的光易分解物质之间至少隔有一层无色透明的高分子材料。
进一步作为本发明技术方案的改进，所述本体环绕预期遮蔽的光易分解物质外周设置；或者所述本体围绕预期遮蔽的光易分解物质设置；或者所述本体设置于两种预期遮蔽的光易分解物质之间；或者所述本体设置于非光易分解物质与预期遮蔽的光易分解物质之间；或者所述本体设置于外设储存预期遮蔽的光易分解物质的容器开口上；或者所述本体设置于含有光易分解物质的液体的液流通道上，本体上设有与液流通道连通的连接口。
进一步作为本发明技术方案的改进，所述遮蔽器由避光材料折叠和/或者延伸形成。
进一步作为本发明技术方案的改进，所述避光材料采用避光膜制作而成。
一种输注装置，所述输注装置包括上述任一密封装置。
进一步作为本发明技术方案的改进，所述输注装置选自输液管路、输液器、留置针、输液针、输液延长管、注射器、输液连接器、输液连接管、滴斗、过滤器。
一种储存装置，所述储存装置包括上述任一密封装置。
进一步作为本发明技术方案的改进，所述储存装置选自输液瓶、输液袋、安瓿、药瓶、试剂瓶、药物箱、储物盒。
本发明的有益效果：此密封装置通过在避光材料与预期遮蔽的光易分解物质之间至少隔有一层无色透明的高分子材料或者其它类型的分隔材料，解决预期遮蔽的光易分解物质与其接触的材料出现反应，从而导致光易分解物质出现理化性质改变的问题，确保光易分解物质的稳定性。
通过在避光材料之间的间隙上设置遮蔽器，解决光线从缝隙间进入，导致光易分解物质见光分解的问题，保持避光性能良好。
附图说明
下面结合附图对本发明作进一步说明：
图1是本发明第一实施例整体结构示意图；
图2是本发明第二实施例整体结构示意图；
图3是本发明第三实施例整体结构示意图；
图4是本发明第四实施例整体结构示意图。
具体实施方式
参照图1～图2，一种密封装置，包括设有可分隔空间15的本体 1；所述可分隔空间15通过本体1分隔成第一分隔空间16和第二分隔空间17；所述本体1外侧覆盖避光材料4和/或者本体1上夹有避光材料4；所述密封装置在避光材料4之间的间隙上设有至少遮挡在上述间隙的一侧且超过上述间隙间距长度的遮蔽器43。
通过在避光材料之间的间隙上设置遮蔽器，解决光线从缝隙间进入，导致光易分解物质见光分解的问题，保持避光性能良好。
第一分隔空间16和第二分隔空间17可以是两个独立的密闭的分隔空间；或者可以是其中一个是独立的密闭的分隔空间，另一个是开放的分隔空间；或者可以是其中一个是与其它空间连通的密闭的分隔空间，另一个是开放的分隔空间；或者可以是其中一个是与其它空间连通的密闭的分隔空间，另一个是独立的密闭的分隔空间。
作为本发明优选的实施方式，所述避光材料4与预期遮蔽的光易分解物质之间至少隔有一层分隔材料42，所述分隔材料42与预期遮蔽的光易分解物质接触不发生理化性质改变；或者所述避光材料4与预期遮蔽的光易分解物质之间至少隔有一层分隔材料42，预期遮蔽的光易分解物质与所述分隔材料42接触不发生理化性质改变；或者所述避光材料4与预期遮蔽的光易分解物质之间至少隔有一层分隔材料42，所述分隔材料42与预期遮蔽的光易分解物质接触而彼此不发生理化性质改变。
作为本发明优选的实施方式，所述避光材料4与预期遮蔽的光易分解物质之间至少隔有一层无色透明的高分子材料420。
优选的，本体作为分隔材料的一部份或全部设置，当然，本体与 分隔材料也可以是彼此独立设置。
优选的，分隔材料采用无色透明的高分子材料。
通过在避光材料与预期遮蔽的光易分解物质之间至少隔有一层分隔材料，具体可以在避光材料与预期遮蔽的光易分解物质之间至少隔有一层无色透明的高分子材料，解决预期遮蔽的光易分解物质与其接触的分隔材料出现反应，从而导致光易分解物质出现理化性质改变的问题；或者解决预期遮蔽的光易分解物质与其接触的分隔材料出现反应，导致分隔材料出现理化性质改变，从而减少理化性质改变的分隔材料与避光材料相互间可能导致避光材料出现理化性质改变，影响避光性能，进而导致光易分解物质出现理化性质改变的问题。
预期遮蔽的光易分解物质包括具有易光分解性质的药物、试剂、配剂、原料和其它物料。
作为本发明优选的实施方式，所述本体1环绕预期遮蔽的光易分解物质外周设置；或者所述本体1围绕预期遮蔽的光易分解物质设置；或者所述本体1设置于两种预期遮蔽的光易分解物质之间；或者所述本体1设置于非光易分解物质与预期遮蔽的光易分解物质之间；或者所述本体1设置于外设储存预期遮蔽的光易分解物质的容器开口上；或者所述本体1设置于含有光易分解物质的液体的液流通道上，本体1上设有与液流通道连通的连接口。
作为本发明优选的实施方式，所述遮蔽器43由避光材料4折叠和/或者延伸形成。
作为本发明优选的实施方式，所述避光材料4采用避光膜41制 作而成。避光材料也可以采用铝箔、遮光纸、遮光布、不透光材料等其它材料制作而成。避光材料可以设有一层，也可以是两层或两层以上，在两层以上材料时，可以采用不同材质、类型的避光材料。
参照图3，一种输注装置，所述输注装置包括上述任一密封装置。
作为本发明优选的实施方式，所述输注装置选自输液管路、输液器、留置针、输液针、输液延长管、注射器、输液连接器、输液连接管、滴斗、过滤器。
参照图4，一种储存装置，所述储存装置包括上述任一密封装置。
作为本发明优选的实施方式，所述储存装置选自输液瓶、输液袋、安瓿、药瓶、试剂瓶、药物箱、储物盒。

Claims (9)

  1. 一种密封装置，包括设有可分隔空间的本体；所述可分隔空间通过本体分隔成第一分隔空间和第二分隔空间；所述本体外侧覆盖避光材料和/或者本体上夹有避光材料；所述密封装置在避光材料之间的间隙上设有至少遮挡在上述间隙的一侧且超过上述间隙间距长度的遮蔽器。
  2. 根据权利要求1所述的密封装置，其特征在于：所述避光材料与预期遮蔽的光易分解物质之间至少隔有一层分隔材料，所述分隔材料与预期遮蔽的光易分解物质接触不发生理化性质改变；或者所述避光材料与预期遮蔽的光易分解物质之间至少隔有一层分隔材料，预期遮蔽的光易分解物质与所述分隔材料接触不发生理化性质改变；或者所述避光材料与预期遮蔽的光易分解物质之间至少隔有一层分隔材料，所述分隔材料与预期遮蔽的光易分解物质接触而彼此不发生理化性质改变。
  3. 根据权利要求1所述的密封装置，其特征在于：所述避光材料与预期遮蔽的需避光药物之间至少隔有一层无色透明的高分子材料。
  4. 根据权利要求1所述的密封装置，其特征在于：所述本体环绕预期遮蔽的光易分解物质外周设置；或者所述本体围绕预期遮蔽的光易分解物质设置；或者所述本体设置于两种预期遮蔽的光易分解物质之间；或者所述本体设置于非光易分解物质与预期遮蔽的光易分解物质之间；或者所述本体设置于外设储存预期遮蔽的光 易分解物质的容器开口上；或者所述本体设置于含有光易分解物质的液体的液流通道上，本体上设有与液流通道连通的连接口。
  5. 根据权利要求1所述的密封装置，其特征在于：所述遮蔽器由避光材料折叠和/或者延伸形成。
  6. 一种输注装置，所述输注装置包括上述权利要求1～5中任一密封装置。
  7. 根据权利要求6所述的输注装置，其特征在于：所述输注装置选自输液管路、输液器、留置针、输液针、输液延长管、注射器、输液连接器、输液连接管、滴斗、过滤器。
  8. 一种储存装置，所述储存装置包括上述权利要求1～5中任一密封装置。
  9. 根据权利要求8所述的储存装置，其特征在于：所述储存装置选自输液瓶、输液袋、安瓿、药瓶、试剂瓶、药物箱、储物盒。
PCT/CN2017/105280 2016-01-02 2017-10-08 一种密封装置 WO2018068684A1 (zh)

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CN201710121811.0A CN107007901A (zh) 2016-01-02 2017-03-02 一种密封装置
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