WO2017220051A3 - 盐酸苄丝肼的药物组合物及其降血糖的医药用途 - Google Patents

盐酸苄丝肼的药物组合物及其降血糖的医药用途 Download PDF

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Publication number
WO2017220051A3
WO2017220051A3 PCT/CN2017/097789 CN2017097789W WO2017220051A3 WO 2017220051 A3 WO2017220051 A3 WO 2017220051A3 CN 2017097789 W CN2017097789 W CN 2017097789W WO 2017220051 A3 WO2017220051 A3 WO 2017220051A3
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WO
WIPO (PCT)
Prior art keywords
blood sugar
lowering blood
pharmaceutical composition
benserazide hydrochloride
medical use
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PCT/CN2017/097789
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English (en)
French (fr)
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WO2017220051A2 (zh
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崔坤峰
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赵吉永
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Publication of WO2017220051A2 publication Critical patent/WO2017220051A2/zh
Publication of WO2017220051A3 publication Critical patent/WO2017220051A3/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/527—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings
    • C07C49/557—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings having unsaturation outside the rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明公开了盐酸苄丝肼的药物组合物及其降血糖的医药用途，本发明提供的盐酸苄丝肼的药物组合物中含有盐酸苄丝肼和一种从天麻的干燥块茎中分离得到的结构新颖的天然产物化合物(Ⅰ)，盐酸苄丝肼和该天然产物化合物(Ⅰ)单独作用时，具有降血糖作用；二者联合作用时，降血糖效果进一步提高，可以开发成降血糖的药物，与现有技术相比具有突出的实质性特点和显著的进步。
PCT/CN2017/097789 2016-06-23 2017-08-17 盐酸苄丝肼的药物组合物及其降血糖的医药用途 WO2017220051A2 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610459119.4 2016-06-23
CN201610459119.4A CN106045835A (zh) 2016-06-23 2016-06-23 盐酸苄丝肼的药物组合物及其降血糖的医药用途

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WO2017220051A2 WO2017220051A2 (zh) 2017-12-28
WO2017220051A3 true WO2017220051A3 (zh) 2018-02-15

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CN (1) CN106045835A (zh)
WO (1) WO2017220051A2 (zh)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106045835A (zh) * 2016-06-23 2016-10-26 崔坤峰 盐酸苄丝肼的药物组合物及其降血糖的医药用途

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CN106045835A (zh) 2016-10-26
WO2017220051A2 (zh) 2017-12-28

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