WO2017187744A9 - 光学的検出方法及び光学的検出装置 - Google Patents

光学的検出方法及び光学的検出装置 Download PDF

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WO2017187744A9
WO2017187744A9 PCT/JP2017/006759 JP2017006759W WO2017187744A9 WO 2017187744 A9 WO2017187744 A9 WO 2017187744A9 JP 2017006759 W JP2017006759 W JP 2017006759W WO 2017187744 A9 WO2017187744 A9 WO 2017187744A9
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front surface
target substance
conjugate
optical detection
optical
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WO2017187744A1 (ja
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雅人 安浦
藤巻　真
裕樹 芦葉
島　隆之
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国立研究開発法人産業技術総合研究所
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Priority to US16/097,121 priority Critical patent/US10976255B2/en
Priority to JP2018514147A priority patent/JP7008334B2/ja
Priority to CN201780023359.2A priority patent/CN109154561B/zh
Priority to EP17789033.2A priority patent/EP3450961B1/en
Publication of WO2017187744A1 publication Critical patent/WO2017187744A1/ja
Publication of WO2017187744A9 publication Critical patent/WO2017187744A9/ja

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G01N21/553—Attenuated total reflection and using surface plasmons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles

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  • Health & Medical Sciences (AREA)
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  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
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Abstract

【課題】近接場を用いて、微小な標的物質を、高感度でかつ迅速に検出する光学的検出方法及び装置を提供する。 【解決手段】近接場を用いて検出板の表面上の標的物質を含む結合体による蛍光等を光信号として検出する標的物質の光学的検出方法であって、結合体は少なくとも標的物質と磁性粒子の結合によって形成され、結合体を表面に平行な方向又は前記表面から遠ざける方向に移動等させる第１の磁場の印加によって生じる光信号の低減等を計測して、標的物質を検出する。光学的検出装置は、裏面側から全反射条件で照射される光により表面上に近接場を形成可能な検出板を備え、かつ標的物質を含む液体の試料及び標的物質と結合体を形成する磁性粒子を検出板の表面上に保持可能な液体保持部と、光照射部と、光検出部と、結合体を表面に平行な方向又は表面から遠ざける方向に移動させる磁場を印加する磁場印加部等とを備える。
PCT/JP2017/006759 2016-04-28 2017-02-23 光学的検出方法及び光学的検出装置 WO2017187744A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US16/097,121 US10976255B2 (en) 2016-04-28 2017-02-23 Optical detection method and optical detection device
JP2018514147A JP7008334B2 (ja) 2016-04-28 2017-02-23 光学的検出方法及び光学的検出装置
CN201780023359.2A CN109154561B (zh) 2016-04-28 2017-02-23 光学检测方法及光学检测装置
EP17789033.2A EP3450961B1 (en) 2016-04-28 2017-02-23 Optical detection method and optical detection device

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JP2016090662 2016-04-28
JP2016-090662 2016-04-28
JP2016245113 2016-12-19
JP2016-245113 2016-12-19

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WO2017187744A9 true WO2017187744A9 (ja) 2018-12-13

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US (1) US10976255B2 (ja)
EP (1) EP3450961B1 (ja)
JP (1) JP7008334B2 (ja)
CN (1) CN109154561B (ja)
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US10976255B2 (en) 2021-04-13
CN109154561A (zh) 2019-01-04
JP7008334B2 (ja) 2022-01-25
EP3450961A4 (en) 2019-12-25
JPWO2017187744A1 (ja) 2019-03-07
WO2017187744A1 (ja) 2017-11-02
EP3450961B1 (en) 2021-04-21
EP3450961A1 (en) 2019-03-06
CN109154561B (zh) 2021-04-13
US20190154580A1 (en) 2019-05-23

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