WO2017047803A1 - Procédé de production d'une préparation contenant un épaississant polysaccharidique - Google Patents

Procédé de production d'une préparation contenant un épaississant polysaccharidique Download PDF

Info

Publication number
WO2017047803A1
WO2017047803A1 PCT/JP2016/077587 JP2016077587W WO2017047803A1 WO 2017047803 A1 WO2017047803 A1 WO 2017047803A1 JP 2016077587 W JP2016077587 W JP 2016077587W WO 2017047803 A1 WO2017047803 A1 WO 2017047803A1
Authority
WO
WIPO (PCT)
Prior art keywords
gum arabic
thickening polysaccharide
mass
raw material
preparation
Prior art date
Application number
PCT/JP2016/077587
Other languages
English (en)
Japanese (ja)
Inventor
佐藤　寛之
拓也 松尾
Original Assignee
三栄源エフ・エフ・アイ株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 三栄源エフ・エフ・アイ株式会社 filed Critical 三栄源エフ・エフ・アイ株式会社
Priority to JP2017540038A priority Critical patent/JP6800860B2/ja
Publication of WO2017047803A1 publication Critical patent/WO2017047803A1/fr

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

Definitions

  • the present invention relates to a method for producing a preparation containing a thickening polysaccharide (hereinafter also referred to as “thickening polysaccharide-containing preparation”), and a method for improving the dispersibility of a preparation containing a thickening polysaccharide in a liquid.
  • thickening polysaccharide-containing preparation a thickening polysaccharide
  • Formulations containing thickening polysaccharides such as xanthan gum have a function of imparting viscosity to various compositions such as food and drink (viscosity imparting function) and a function of gelling various compositions (gelling function).
  • Patent Document 1 proposes a technique for granulating xanthan gum powder having an average particle diameter of 80 ⁇ m or less.
  • the fine powder type xanthan gum having an average particle diameter of 80 ⁇ m or less has a problem that the powder is easily scattered when the powder is handled.
  • the xanthan gum-containing preparation obtained based on the present technology is not sufficiently dispersible in a liquid, and still has a problem that lumps are easily generated.
  • Patent Document 2 uses at least one of powdery or granular thickening polysaccharide and at least one of gum arabic, pullulan, soybean polysaccharide, and arabinogalactan. Technology has been proposed.
  • the dispersibility improvement effect of the thickening polysaccharide by this technique is not sufficient.
  • a thickening polysaccharide-containing preparation is added while stirring the liquid at high speed by mechanical stirring or the like, the occurrence of lumps is somewhat suppressed, but stirring is performed at a slow speed (slow speed) such as manual stirring.
  • the technique disclosed in Patent Document 2 cannot sufficiently suppress the occurrence of lumps.
  • Patent Document 3 discloses as Comparative Example 4 an example in which xanthan gum powder is granulated using a binder liquid containing gum arabic.
  • Comparative Example 4 an example in which xanthan gum powder is granulated using a binder liquid containing gum arabic.
  • this comparative example it is not recognized that the dispersibility of xanthan gum has been sufficiently improved.
  • Patent Document 4 xanthan gum powder is granulated using a binder liquid containing gum arabic, and then the resulting granulated material mixed with a disintegrant and an excipient is molded into a tablet. A formulation is disclosed. However, Patent Document 4 does not disclose any use of gum arabic for both the powder composition containing the thickening polysaccharide and the binder liquid.
  • the occurrence of lumps is based on the high hydration (dissolution) rate of the thickening polysaccharide. Therefore, the conventional technology for the purpose of suppressing the occurrence of lumps causes a delay in the dissolution rate of the thickening polysaccharide, resulting in a decrease in the viscosity imparting function or the gelling function inherently possessed by the thickening polysaccharide.
  • the present invention is an invention made in view of such problems, and the generation of lumps is suppressed, and the thickening polysaccharide contains the thickening polysaccharide, which is originally excellent in the expression of the viscosity imparting function or the gelling function.
  • the purpose is to provide a formulation.
  • the present inventors obtained a granulating raw material (raw material composition) containing gum arabic and a thickening polysaccharide other than gum arabic as a binder liquid containing gum arabic. It has been found that by using and granulating, it is possible to provide a thickened polysaccharide-containing preparation in which dispersibility in a liquid is improved and generation of lumps is suppressed. In addition, the present inventors have found that the thickening polysaccharide-containing preparation produced using the present technology can exhibit an excellent viscosity imparting function or gelling function with respect to a liquid, and as a result of further research, The present invention has been completed.
  • the present invention relates to a method for producing a thickening polysaccharide-containing preparation having the following aspects, and a method for improving the dispersibility of a preparation containing a thickening polysaccharide in a liquid.
  • Method for producing thickening polysaccharide-containing preparation Item 1-1. It is a method for producing a preparation containing a thickening polysaccharide, A method for producing a thickening polysaccharide-containing preparation, characterized by granulating a gum raw material containing gum arabic and a thickening polysaccharide other than gum arabic using a binder liquid containing gum arabic. Item 1-2. Item 11.
  • the thickening polysaccharide according to item 1-1 wherein the thickening polysaccharide other than gum arabic contains one or more selected from the group consisting of xanthan gum, carrageenan, galactomannan, pectin, gellan gum, and alginic acids.
  • a method for producing a polysaccharide-containing preparation Item 1-3. Item 1-1 or 1- wherein the amount of gum arabic derived from the granulation raw material is 0.5 parts by mass or more with respect to 1 part by mass of gum arabic derived from the binder liquid in the thickening polysaccharide-containing preparation 2.
  • Method for improving the dispersibility of a preparation containing a thickening polysaccharide in a liquid ⁇ br> 2-1 A granulating raw material containing gum arabic and a thickening polysaccharide other than gum arabic is granulated using a binder liquid containing gum arabic, to a liquid of a formulation containing a thickening polysaccharide A method to improve dispersibility.
  • Item 2-2. Item 2. The method according to Item 2-1, wherein the polysaccharide thickener other than gum arabic contains one or more selected from the group consisting of xanthan gum, carrageenan, galactomannan, pectin, gellan gum, and alginic acids.
  • Item 2-3 The method according to Item 2-1, wherein the polysaccharide thickener other than gum arabic contains one or more selected from the group consisting of xanthan gum, carrageenan, galactomannan, pectin, gellan gum, and
  • Item 2-1 or 2- wherein in the thickening polysaccharide-containing preparation, the amount of gum arabic derived from the granulated raw material is 0.5 parts by weight or more with respect to 1 part by weight of gum arabic derived from the binder liquid 2.
  • the method according to 2. Item 2-4.
  • Item 4. The method according to any one of Items 2-1 to 2-3, wherein the gum arabic content in the thickening polysaccharide-containing preparation is 0.1 to 60% by mass.
  • Item 2-5 Any one of Items 2-1 to 2-4, wherein the gum arabic content in the thickening polysaccharide-containing preparation is 0.01 to 5 parts by weight with respect to 1 part by weight of the thickening polysaccharide other than the gum arabic. 2.
  • a thickening polysaccharide-containing preparation with improved dispersibility in a liquid and suppressed occurrence of lumps.
  • a thickening polysaccharide-containing preparation capable of exhibiting an excellent viscosity imparting function or gelling function with respect to a liquid such as water.
  • Experimental Example 1 it is a photograph which shows the dispersibility test result of the thickening polysaccharide containing formulation of Comparative Example 1-2.
  • Experimental example 2 it is a photograph which shows the dispersibility test result of the thickening polysaccharide containing formulation of Example 2.
  • FIG. 5 it is a photograph which shows the dispersibility test result (standing time 5 second) of the thickening polysaccharide containing formulation of Example 5.
  • the present invention provides a thickening polysaccharide-containing preparation characterized by granulating a gum raw material containing a thickening polysaccharide other than gum arabic and gum arabic using a binder liquid containing gum arabic Regarding the method.
  • the thickening polysaccharides other than gum arabic used in the present invention are not particularly limited, but in the present invention, edible thickening polysaccharides that are permitted to be used in foods and drinks or oral medicines are preferably used.
  • thickening polysaccharides other than gum arabic examples include xanthan gum, carrageenan (eg, kappa type carrageenan, iota type carrageenan, lambda type carrageenan, etc.), galactomannan (eg, locust bean gum, tara gum, gua gum, etc.), alginic acid.
  • carrageenan eg, kappa type carrageenan, iota type carrageenan, lambda type carrageenan, etc.
  • galactomannan eg, locust bean gum, tara gum, gua gum, etc.
  • alginic acid examples include xanthan gum, carrageenan (eg, kappa type carrageenan, iota type carrageenan, lambda type carrageenan, etc.), galactomannan (eg, locust bean gum, tara gum, gua gum, etc.), alginic acid.
  • alginic acid alginates (eg, sodium alginate, potassium alginate, calcium alginate, etc.), alginates (eg, propylene glycol alginate, etc.)), pectin (eg, low methoxyl (LM) pectin, high methoxyl (HM) ) Pectin), gellan gum (eg, deacylated gellan gum, native gellan gum, etc.), agar, gelatin, tamarind seed gum, glucomannan, welan gum, psyllium seed gum, Rayagamu, curdlan, pullulan, starch, furcellaran, fermented cellulose, crystalline cellulose, soybean polysaccharides, and the like. These may be used alone or in combination of two or more.
  • xanthan gum, carrageenan, galactomannan, pectin, gellan gum, alginic acids, particularly xanthan gum are particularly difficult to suppress the occurrence of lumps because of their high hydration rate.
  • a preparation containing such a thickening polysaccharide can remarkably suppress lumps generated when added to a liquid, and contains a thickening polysaccharide excellent in dispersibility.
  • a formulation can be provided.
  • the present invention is suitable for production of a preparation containing one or more selected from the group consisting of xanthan gum, carrageenan, galactomannan, pectin, gellan gum and alginic acids as thickening polysaccharides other than gum arabic. It can be used, and can be used more suitably for the manufacture of a preparation containing xanthan gum as a thickening polysaccharide other than gum arabic.
  • the gum arabic used in the present invention is known and is a polysaccharide obtained from the sap of a plant of the genus Acacia which is a leguminous plant (for example, Acacia senegal or Acacia seyal ). Although the molecular structure of gum arabic has not been fully clarified, it is known that galactose, arabinose, rhamnose, and glucuronic acid are used as constituent sugars.
  • Gum arabic is commercially available. Examples of such products include “Gum Arabic SD” manufactured by San-Ei Gen FFI Co., Ltd.
  • modified gum arabic obtained by modifying the gum arabic can also be used as gum arabic.
  • modification method include a method of heat treatment at 90 to 180 ° C. for 15 minutes to 72 hours, a method of removing or reducing a metal salt from gum arabic, and the like.
  • the method for removing or reducing the metal salt from gum arabic include an ion exchange treatment in an organic solvent, an electrodialysis membrane, or a desalting treatment with an ion exchange resin or the like.
  • These modified gum arabic can be produced, for example, according to the method described in JP-T-2006-522202 or JP-A-2005-179417.
  • gum arabic is not limited as described above.
  • the weight average molecular weight is preferably 900,000 to 5,000,000, more preferably 1,200,000 to 5,000,000, and still more preferably 1,500,000 to 500,000.
  • the content of gum arabic and / or arabinogalactan protein is preferably 17 to 30% by mass, more preferably 20 to 30% by mass, even more preferably 1.5 to 4.5 million, particularly preferably 2 to 4 million.
  • % Gum arabic is exemplified.
  • the weight average molecular weight and arabinogalactan protein content (mass%) of gum arabic were equipped with three detectors, for example, a light scattering (MALLS) detector, a refractive index (RI) detector, and an ultraviolet (UV) detector. It can be measured by gel filtration chromatography. Specifically, it can be measured according to the method described in JP-T-2006-522202.
  • MALLS light scattering
  • RI refractive index
  • UV ultraviolet
  • the modified gum arabic having the above properties can be produced, for example, according to the method described in JP-T-2006-522202. As an example, by modifying gum arabic belonging to the species Acacia senegal at 110 ° C. for 10 hours or more, or under conditions that can obtain substantially the same effect, the modification having the above-mentioned properties Gum arabic can be produced. An example of the heating time condition is 72 hours.
  • the modified gum arabic having the above properties can be obtained commercially. Examples of such products include “SUPER GUM EM10” manufactured by San-Ei Gen FFI Co., Ltd.
  • a granulation raw material containing gum arabic and a thickening polysaccharide other than gum arabic is used as the granulation raw material, and the granulation raw material is preferably powdery or granular.
  • the thickening polysaccharide content in this granulated raw material (hereinafter also referred to as “raw material mixture in the present invention” in the present specification) is not particularly limited, for example, derived from the granulating raw material in the thickening polysaccharide-containing preparation
  • the thickening polysaccharide content other than gum arabic is 5 to 80% by mass, preferably 10 to 75% by mass, more preferably 10 to 70% by mass, still more preferably 10 to 60% by mass, and even more preferably 15 to 55%.
  • the thickening polysaccharide is contained in the granulation raw material so that the content is 20% by mass, particularly preferably 20 to 55% by mass, more preferably 20 to 50% by mass, and still more preferably 20 to 45% by mass. .
  • the thickening polysaccharide derived from the granulation raw material contains one or more selected from the group consisting of xanthan gum, carrageenan, galactomannan, pectin, gellan gum and alginic acids
  • the content of one or more thickening polysaccharides selected from the group consisting of xanthan gum, carrageenan, galactomannan, pectin, gellan gum and alginic acids is 5-80.
  • % By weight, preferably 10 to 75% by weight, more preferably 10 to 70% by weight, still more preferably 10 to 60% by weight, still more preferably 15 to 55% by weight, particularly preferably 20 to 55% by weight, still more particularly
  • the content is preferably 20 to 50% by mass, and more preferably 20 to 45% by mass.
  • xanthan gum is excellent in viscosity development with respect to liquids such as water and is useful as a thickening agent, but has a problem that lumps tend to occur remarkably.
  • the xanthan gum content in the thickening polysaccharide-containing preparation is 5 mass% or more, 8 mass% or more, 10 mass% or more, 12 mass% or more, 15 mass% or more, 20 mass% or more.
  • xanthan gum content is as high as 25% by mass or more, or 28% by mass or more, it is possible to provide a thickening polysaccharide-containing preparation that suppresses the occurrence of xanthan gum lumps and has an excellent viscosity-imparting function.
  • the upper limit of the xanthan gum content in the thickening polysaccharide-containing preparation is not particularly limited, for example, 80 mass% or less, 75 mass% or less, 70 mass% or less, 65 mass% or less, 60 mass% or less, 55 mass% or less, or 50 mass% or less is illustrated.
  • the thickened polysaccharide-containing preparation obtained by the production method of the present invention contains xanthan gum
  • the xanthan gum content in the thickened polysaccharide-containing preparation is, for example, 5 to 80% by mass, preferably 8 to 75% by mass, more preferably 10 to 70% by mass, still more preferably 12 to 65% by mass, still more preferably 15 to 60% by mass, and particularly preferably 20 to 55% by mass. %, More preferably 25 to 50% by weight, even more preferably 25 to 45% by weight.
  • the gum arabic content in the granulated raw material in the present invention is not particularly limited.
  • the gum arabic content derived from the granulated raw material is 0.1 to 50% by mass, preferably 0.1 to 45% by mass, more preferably 0.2 to 40% by mass, still more preferably 0.25 to 35% by mass, still more preferably 0.25 to 25% by mass, and particularly preferably 0.5 to 25% by mass. It is desirable to add gum arabic to the granulation raw material so that it may become the mass%.
  • “derived from the granulation raw material” means, in other words, “not derived from the binder liquid used in the production”.
  • a granulation raw material with respect to 1 mass part of thickening polysaccharides other than gum arabic derived from a granulation raw material in a thickening polysaccharide containing formulation is from 0.01 to 5 parts by weight, more preferably from 0.01 to 3 parts by weight, still more preferably from 0.015 to 2 parts by weight, It is even more preferable that the amount is 015 to 1 part by mass.
  • an excipient to the granulation raw material containing gum arabic and thickening polysaccharide other than gum arabic. That is, in one preferred embodiment of the production method of the present invention, a granulation raw material containing gum arabic, a thickening polysaccharide other than gum arabic and an excipient is granulated using a binder liquid containing gum arabic.
  • the present invention relates to a method for producing a thickening polysaccharide-containing preparation.
  • the excipient used in the present invention is not particularly limited, but in the present invention, it is preferable to use an excipient that is permitted for use in foods and drinks or oral medicines.
  • excipients include, for example, starch degradation products (eg, dextrin, powdered rice cake, etc.), saccharides (eg, monosaccharide (eg, glucose, fructose, etc.), disaccharides (eg, sucrose, lactose, maltose, trehalose, etc.) ), Oligosaccharides (eg, cellooligosaccharides, malto-oligosaccharides, fructooligosaccharides, etc.), sugar alcohols (eg, xylitol, sorbitol, lactitol, maltitol, etc.), reduced saccharified products, etc., dietary fibers (eg, indigestible dextrin, Polydextrose, guar gum enzymatic degradation products, etc.). These may be used alone or in combination of two or more.
  • saccharides eg, monosaccharide (eg, glucose, fructose, etc.), disaccharides
  • the content of the excipient is not particularly limited.
  • the excipient content in the thickening polysaccharide-containing preparation is 10 to 90% by mass, preferably 20 to 85% by mass
  • An excipient can be used such that the amount is more preferably 30 to 80% by mass, still more preferably 35 to 75% by mass, and particularly preferably 40 to 75% by mass.
  • the granulation raw material in the present invention may also contain a metal salt for the purpose of further improving dispersibility.
  • the type of metal salt is not particularly limited, and examples thereof include potassium salt, sodium salt, calcium salt, magnesium salt, and the like. Specifically, these chlorides, hydroxides, lactates, citrates, glucones, etc. Acid salts, phosphates, sulfates, malates and the like can be mentioned.
  • the metal salt permitted to use for food and drink or oral medicine.
  • Examples of such metal salts include calcium chloride, potassium chloride, sodium chloride, magnesium chloride, calcium lactate, sodium citrate, sodium gluconate, and potassium gluconate.
  • Preferred metal salts are one or more selected from the group consisting of calcium chloride, potassium chloride, sodium citrate and sodium gluconate. These may be used alone or in combination of two or more.
  • the content of the metal salt is not particularly limited.
  • the metal salt content in the thickening polysaccharide-containing preparation is 0.5 to 10% by mass, preferably 0.8 to 8% by mass. More preferably, a metal salt can be used so that the content is 1 to 6% by mass, more preferably 1 to 5.5% by mass, and still more preferably 1.5 to 5% by mass.
  • the production method of the present invention is characterized by granulating a raw material containing gum arabic and a thickening polysaccharide other than gum arabic using a binder liquid containing gum arabic.
  • the content of gum arabic in the binder liquid used in the present invention is not particularly limited, and examples thereof include 0.1 to 25% by mass, preferably 0.2 to 20% by mass, more preferably 0.3 to 18% by mass. %, More preferably 0.5 to 15% by weight, still more preferably 0.5 to 10% by weight.
  • the binder liquid can be prepared by dissolving gum arabic in water. From this, in the present invention, the binder liquid containing gum arabic preferably contains water. Note that gum arabic can be dissolved in water at around room temperature (for example, 20 ° C.), so a heating step is not necessary when preparing the binder liquid, but the mixture of water and gum arabic is heated as necessary. May be.
  • the binder liquid used in the present invention may contain an alcohol having 3 or less carbon atoms (for example, methanol, ethanol, glycerin, etc.), a metal salt, or an organic acid.
  • an alcohol having 3 or less carbon atoms for example, methanol, ethanol, glycerin, etc.
  • a metal salt for example, a metal salt, or an organic acid.
  • the binder liquid used in the present invention is not limited to this, but may further contain pullulan.
  • Pullulan is a known ⁇ -glucan produced by Aureobasidium pullulas (filamentous fungi), a kind of black yeast. Its structure is a linear polysaccharide in which maltotriose regularly repeats ⁇ -1,6-glucoside bonds.
  • thickening polysaccharides particularly xanthan gum, carrageenan, galactomannan, pectin, gellan gum, alginic acids, are likely to generate lumps. Even a thickening polysaccharide can improve dispersibility. From this viewpoint, it can be said that the combined use of gum arabic and pullulan is preferable as one component of the binder liquid.
  • the content of pullulan in the binder liquid is not particularly limited, and examples thereof include 0.1 to 20% by mass, preferably 0.2 to 18% by mass, and more preferably 0.8%. It is 5 to 15% by mass, more preferably 0.8 to 12% by mass, still more preferably 1 to 10% by mass, and particularly preferably 1 to 8% by mass.
  • the granulation method employed in the method for producing the thickening polysaccharide-containing preparation of the present invention is not particularly limited.
  • a granulation method a fluidized bed granulation method, an agitation granulation method, an extrusion granulation method, a rolling granulation method and the like can be exemplified, and a preferred granulation method is a fluidized bed granulation method or an agitation granulation method. It is.
  • Granulation by the fluidized bed granulation method is not particularly limited, and can be performed according to a conventional method.
  • one embodiment of granulation by the fluidized bed granulation method is shown below.
  • ⁇ Agglomerated raw material (raw material composition) containing thickening polysaccharide other than gum arabic and gum arabic is put into a granulator, and the granulated raw material is fluidized by sending hot air from below the machine.
  • the fluidized bed is sprayed with a binder liquid, and the binder liquid is adhered to the surface of the granulated raw material to form agglomerated particles of the granulated raw material, and dried to produce a granulated product.
  • granulation by the stirring granulation method is not particularly limited, and can be performed according to a conventional method.
  • granulation by the stirring granulation method is shown below.
  • ⁇ Granulated raw materials containing gum arabic and thickening polysaccharides other than gum arabic are placed in a granulator, and the binder liquid is sprayed or directly charged and stirred at high speed.
  • the agglomerated raw materials form agglomerated particles by stirring and are dried to produce a granulated product.
  • Granulation by other extrusion granulation methods and rolling granulation methods is not particularly limited, and can be performed according to a conventional method.
  • the method of using the binder liquid is not particularly limited.
  • the method of spraying a binder liquid to the granulation raw material containing thickening polysaccharides other than gum arabic and gum arabic can be illustrated, and if it is a stirring granulation method , A method of spraying a binder liquid onto a granulated raw material containing gum thickener other than gum arabic and gum arabic, or a method of mixing a granulated raw material containing thickening polysaccharide other than gum arabic and gum arabic and a binder liquid Can be illustrated.
  • the amount of the binder liquid used in the present invention is not particularly limited, but the gum arabic content derived from the binder liquid in the thickening polysaccharide-containing preparation is 0.05 to 10% by mass, preferably 0.08 to 9% by mass, More preferably 0.1 to 9% by weight, still more preferably 0.1 to 8% by weight, still more preferably 0.15 to 8% by weight, particularly preferably 0.15 to 6% by weight, and still more preferably 0. It is preferable to adjust the amount of the binder liquid so as to be 2 to 6% by mass.
  • the content (total amount) of gum arabic and pullulan derived from the binder liquid in the thickening polysaccharide-containing preparation is, for example, 0.3 to 10% by weight, preferably 0.4 to 9% by weight, more preferably 0.5 to 8% by weight, and even more preferably 0.6 to 6% by weight, gum arabic in the binder liquid It is preferable to adjust the pullulan content.
  • the use of gum arabic is excellent in dispersibility in a liquid by using a granulated raw material that is a raw material composition and a binder liquid used when granulating the granulated raw material.
  • a thickening polysaccharide-containing preparation is produced that is excellent in the functions (viscosity imparting function, gelling function) inherent to the thickening polysaccharide (effectively demonstrates the functions inherent to the thickening polysaccharide). be able to.
  • the thickening polysaccharide in the granulation of the thickening polysaccharide, can be subjected to multistage granulation by a plurality of steps.
  • multistage granulation some preferred embodiments in the case of two-stage granulation (secondary granulation) are shown below, but the present invention is not limited to these.
  • Granulation raw material primary granulation raw material
  • thickening polysaccharide other than powdered gum arabic using a binder liquid containing gum arabic Get the granules.
  • the granulated raw material (secondary granulated raw material) containing the primary granulated product is granulated to obtain a secondary granulated product.
  • a granulated raw material (primary granulated raw material) containing a powdered gum arabic and a thickening polysaccharide other than powdered gum arabic is granulated to obtain a primary granulated product.
  • the granulated raw material (secondary granulated raw material) containing the primary granulated product is granulated using a binder liquid containing gum arabic to obtain a secondary granulated product.
  • a granulated raw material (primary granulated raw material) containing a thickening polysaccharide other than powdered gum arabic is granulated using a binder liquid containing gum arabic to obtain a primary granulated product.
  • a granulated raw material (secondary granulated raw material) containing the primary granulated product and gum arabic is granulated to obtain a secondary granulated product.
  • a granulated raw material (primary granulated raw material) containing a thickening polysaccharide other than powdered gum arabic is granulated to obtain a primary granulated product.
  • the granulated raw material (secondary granulated raw material) containing the primary granulated product and gum arabic is granulated using a binder liquid containing gum arabic to obtain a secondary granulated product.
  • the kind of binder liquid at the time of granulation in case there is no description is not specifically limited,
  • the aqueous solution containing water or gum arabic etc. can be used.
  • an agglomerated raw material contain gum arabic further.
  • the granulated raw material (secondary granulated raw material) containing the primary granulated product and gum arabic is granulated using a binder liquid containing gum arabic to obtain a secondary granulated product.
  • gum arabic is used as one component of the binder liquid used when granulating the granulated raw material, and gum arabic not derived from the binder liquid is used in the granulated raw material.
  • a thickening polysaccharide-containing preparation that is excellent in dispersibility in a liquid and that is excellent in the functions (viscosity imparting function and gelling function) that the thickening polysaccharide originally has.
  • the present invention is characterized in that a binder liquid containing gum arabic is used as the binder liquid.
  • a binder liquid containing gum arabic is used as the binder liquid.
  • binder liquid containing gum arabic either at the time of primary granulation or at the time of secondary granulation, water etc. can be used as a binder liquid at the time of other granulation, for example.
  • the content of thickening polysaccharide in the granulation raw material (raw material composition) at the time of primary granulation and / or secondary granulation can be appropriately adjusted according to the blending ratio described above.
  • the thickening polysaccharide content other than gum arabic is 5 to 80% by mass, preferably 10 to 75% by mass, more preferably 10 to 70% by mass, still more preferably 10 to 60% by mass, and even more preferably 15 to 55% by mass.
  • % Particularly preferably 20 to 55% by weight, still more preferably 20 to 50% by weight Particularly preferred is 20 to 45% by mass.
  • the gum arabic content in the granulated raw material is 0.1 to 50% by mass, preferably 0.1 to 40% by mass, more preferably 0.1 to 35% by mass, still more preferably 0.2 to 30% by mass, More preferably, 0.2 to 25% by mass is exemplified.
  • the excipient content in the granulation raw material is 10 to 90% by mass, preferably 20 to 85% by mass, more preferably 30 to 80% by mass, still more preferably 35 to 75% by mass, and even more preferably 40 to 70% by mass. % Is exemplified.
  • the metal salt content in the granulation raw material is 0.5 to 10% by mass, preferably 0.8 to 8% by mass, more preferably 0.8 to 7% by mass, still more preferably 1 to 6% by mass, and even more preferably. Is 1 to 5.5% by mass.
  • the content of thickening polysaccharide other than gum arabic in the granulation raw material is 20 to 100% by mass, preferably 30 to 100% by mass, more preferably 30 to 95% by mass, and still more preferably 40 to 95%.
  • Examples thereof include a mass%, still more preferably 45 to 90 mass%, particularly preferably 50 to 90 mass%.
  • the gum arabic content in the granulated raw material is 0 to 60% by mass, preferably 0 to 50% by mass, more preferably 0.1 to 40% by mass, still more preferably 0.2 to 35% by mass, and still more preferably 0. 0.3 to 30% by mass, particularly preferably 0.3 to 25% by mass.
  • the excipient content in the granulation raw material is 0 to 80% by mass, preferably 0 to 70% by mass, more preferably 1 to 60% by mass, still more preferably 3 to 50% by mass, and even more preferably 5 to 40% by mass. %, Particularly preferably 5 to 35% by mass.
  • the metal salt content in the granulation raw material is 0 to 15% by mass, preferably 0 to 10% by mass, more preferably 0.5 to 10% by mass, still more preferably 0.5 to 8% by mass, and still more preferably 1 -8% by mass, particularly preferably 2-8% by mass.
  • the content of thickening polysaccharide other than gum arabic in the granulation raw material is 5 to 80% by mass, preferably 10 to 75% by mass, more preferably 10 to 70% by mass, and still more preferably 10%. Examples are ⁇ 60% by mass, even more preferably 15 to 55% by mass, particularly preferably 20 to 55% by mass, and still more preferably 20 to 50% by mass.
  • the gum arabic content in the granulated raw material is 0.1 to 50% by mass, preferably 0.1 to 40% by mass, more preferably 0.1 to 35% by mass, still more preferably 0.2 to 30% by mass, More preferably 0.3 to 25% by mass, particularly preferably 0.5 to 25% by mass.
  • the excipient content in the granulation raw material is 10 to 90% by mass, preferably 20 to 85% by mass, more preferably 30 to 80% by mass, still more preferably 35 to 75% by mass, and even more preferably 40 to 70% by mass. %, Particularly preferably 35 to 65% by mass.
  • the metal salt content in the granulation raw material is 0.5 to 10% by mass, preferably 0.8 to 8% by mass, more preferably 0.8 to 7% by mass, still more preferably 1 to 6% by mass, and even more preferably. Is 1 to 5.5% by mass, particularly preferably 1.5 to 5% by mass.
  • the gum arabic content in the granulation raw material of the present invention and the gum arabic content used as the binder liquid are as described above.
  • the gum arabic gum content (total amount) in the resulting thickened polysaccharide-containing preparation is 0.1-60. % By weight, preferably 0.2 to 45% by weight, more preferably 0.3 to 40% by weight, still more preferably 0.3 to 30% by weight, still more preferably 0.5 to 30% by weight, particularly preferably It is preferable to use gum arabic so that the content is 0.8 to 30% by mass, more preferably 1 to 30% by mass.
  • gum arabic (total amount) is preferably used with respect to 1 part by weight of thickening polysaccharides other than gum arabic contained in the thickening polysaccharide-containing preparation. More preferably, 0.01 to 5 parts by weight of gum arabic is used, more preferably 0.015 to 4 parts by weight of gum arabic, more preferably 0.015 to 3 parts by weight of gum arabic. It is particularly preferable to use 0.02 to 3 parts by mass of gum arabic.
  • the quantity of the gum arabic derived from a granulation raw material is 0.5 mass part or more with respect to 1 mass part of the gum arabic derived from a binder liquid in a thickening polysaccharide containing formulation. Is preferable, and it is more preferable that it is 1 mass part or more.
  • the upper limit of the amount of gum arabic derived from the granulation raw material with respect to 1 part by weight of gum arabic derived from the binder liquid is not particularly limited, but preferably 30 parts by weight, and more preferably 25 parts by weight.
  • the amount of gum arabic derived from the granulated raw material is preferably 0.5 to 30 parts by weight with respect to 1 part by weight of gum arabic derived from the binder liquid.
  • the amount is preferably 1 to 25 parts by mass, more preferably 1 to 20 parts by mass, still more preferably 1 to 10 parts by mass, particularly preferably 1 to 8 parts by mass, and still more preferably 1 to 6 parts by mass.
  • the thickening polysaccharide-containing preparation obtained by the production method of the present invention is excellent in dispersibility in a liquid such as water. For this reason, it has the advantage that it can be used suitably also as a thickening polysaccharide containing formulation used under weak stirring conditions (for example, low speed stirring conditions) such as hand stirring as well as high speed stirring by a machine.
  • the thickening polysaccharide-containing preparation obtained by the production method of the present invention is suitably used as a thickening polysaccharide-containing preparation that is used under stirring at a rotational speed of 400 rpm or less, and further at 180 to 300 rpm. Can be.
  • the thickening polysaccharide-containing preparation obtained by the production method of the present invention has the advantage that it can quickly exhibit the viscosity-imparting function or gelling function that the thickening polysaccharide originally has by adding it to a liquid such as water.
  • a liquid such as water.
  • thickening polysaccharides that are soluble in water near normal temperature such as xanthan gum, carrageenan, guar gum, tara gum, pectin, alginic acids, etc. are used as thickening polysaccharides.
  • the viscous polysaccharide can be easily dissolved in a liquid such as water, and the viscosity can be quickly imparted to the liquid.
  • the thickened polysaccharide-containing preparation obtained by the production method of the present invention has a viscosity ratio A / B measured by the following viscosity development test of 0.2 or more.
  • a viscosity ratio A / B measured by the following viscosity development test of 0.2 or more.
  • ⁇ Viscosity expression test> (1) Put 100 g of ion exchange water (20 ° C.) into a 200 mL beaker, add 2 g of the thickening polysaccharide-containing preparation while stirring using a spatula, and stir for 30 seconds. Stirring is performed at a speed of stirring the beaker 4 times per second (hand stirring at 240 rpm). (2) The solution after stirring is transferred to a screw bottle and allowed to stand, and the viscosity after 0 and 30 minutes is defined as 1 minute after adding the thickening polysaccharide-containing preparation to ion-exchanged water. Measure. The viscosity is measured after rotating for 1 minute at 12 rpm using a BL type rotational viscometer. (3) Viscosity ratio A / B is determined assuming that the viscosity after 0 minute is A (mPa ⁇ s) and the viscosity after 30 minutes is B (mPa ⁇ s).
  • the thickening polysaccharide-containing preparation of the present invention is obtained by multi-stage granulation of secondary granulation or higher, the dispersibility is improved while the viscosity is exhibited as compared with the case obtained by primary granulation. May decrease.
  • the thickening polysaccharide-containing preparation of the present invention is obtained by multi-stage granulation of secondary granulation or higher, if the above-mentioned viscosity ratio A / B is 0.2 or higher, viscosity development is achieved. It can be judged that it is excellent.
  • the viscosity ratio C / B measured by the following viscosity development test is preferably 0.5 or more, more preferably 0.55 or more. , 0.6 or more, still more preferably 0.65 or more, and particularly preferably 0.7 or more. The closer the value of the viscosity ratio C / B is to 1, the better the viscosity expression.
  • ⁇ Viscosity expression test> (1) Put 100 g of ion exchange water (20 ° C.) into a 200 mL beaker, add 2 g of the thickening polysaccharide-containing preparation while stirring using a spatula, and stir for 30 seconds. Stirring is performed at a speed of stirring the beaker 4 times per second (hand stirring at 240 rpm). (2) The solution after stirring is transferred to a screw bottle and allowed to stand, and the viscosity after 5 minutes and 30 minutes is defined as 1 minute after adding the thickening polysaccharide-containing preparation to ion-exchanged water. Measure. The viscosity is measured after rotating for 1 minute at 12 rpm using a BL type rotational viscometer. (3) The viscosity ratio C / B is determined with the viscosity after 5 minutes being C (mPa ⁇ s) and the viscosity after 30 minutes being B (mPa ⁇ s).
  • the thickening polysaccharide-containing preparation obtained by the production method of the present invention can be widely used in various fields.
  • food and drink field for example, pharmaceuticals, quasi-drugs, etc.
  • cosmetics field for example, makeup cosmetics, basic cosmetics, perfume, shampoo, rinse, toothpaste, soap, bath preparation, etc.
  • household goods field for example, detergents, etc.
  • agricultural fields for example, agricultural chemicals
  • industrial fields for example, paints
  • civil engineering fields for example, cement, concrete, soil cleaners, etc.
  • it is the food and drink field.
  • the target food and drink is not particularly limited, water, tea drinks, soft drinks, fruit drinks, coffee drinks, milk drinks, nutritional balance drinks, isotonic drinks, functional drinks, vitamin supplement drinks, powder drinks, alcoholic drinks, Soup, miso soup, stew, curry, rice cake, concentrated liquid food, enteral nutrition, blender meal, chopped meal, mousse meal, paste food, seasoning, dessert, confectionery, frozen dessert, jam, processed meat food, processed agricultural food, Various foods and drinks such as processed fish foods, noodles, and side dishes are listed.
  • the thickening polysaccharide containing formulation manufactured by the manufacturing method of this invention is applied to the liquid (desirably liquid food-drinks) whose water content is 50 mass% or more, and a water content is 60 mass. It is more preferable to be applied to a liquid (preferably a liquid food or drink) that is at least%. This is because the thickening polysaccharide contained in the thickening polysaccharide-containing preparation is sufficiently hydrated and can exhibit the function (eg, viscosity imparting function or gelling function) that the thickening polysaccharide originally has. is there. In addition, when the target object to thicken or gelatinize is less than the said water content, after adding water suitably, a thickening polysaccharide containing formulation can be applied.
  • a thickening polysaccharide containing formulation can be applied.
  • the form of the thickening polysaccharide-containing preparation obtained by the production method of the present invention is not limited.
  • solid forms such as powders, granules, tablets and the like are exemplified, and may be appropriately determined according to the purpose of use.
  • the thickening polysaccharide-containing preparation is preferably exemplified by a powder form, a granule form, and more preferably a granule form from the viewpoint of better usability.
  • the thickening polysaccharide-containing preparation obtained by the production method of the present invention can rapidly exhibit the viscosity imparting function inherent to the thickening polysaccharide with respect to a liquid such as water, thereby increasing the viscosity of the target composition. It is suitable as a thickening agent. In addition, from the viewpoint that the viscosity can be quickly imparted to the target composition even under weak stirring conditions such as hand stirring, it is intended for those who have reduced mastication / swallowing function to give thickness for eating by those who have decreased mastication / swallowing function. It is useful as a thickening agent (for example, thickened food or the like).
  • the thickening polysaccharide-containing preparation obtained by the production method of the present invention can also contain nutritional components, functional components, and the like.
  • nutritional components include vitamins, minerals, amino acids, peptides, proteins, collagen, and the like.
  • the thickening polysaccharide-containing preparation produced in the present invention may contain an emulsifier for the purpose of further improving dispersibility.
  • the time when the emulsifier is added is not particularly limited.
  • an emulsifier may be included as one component of the granulation raw material when granulating the thickening polysaccharide, and the thickening polysaccharide and the emulsifier after granulation may be included. May be mixed to produce a thickening polysaccharide-containing preparation.
  • a thickening polysaccharide-containing preparation may be produced by granulating a granulation raw material using an aqueous solution containing an emulsifier as a binder liquid.
  • the content of the emulsifier in the thickening polysaccharide-containing preparation is not particularly limited.
  • the content is 0.1 to 10% by mass, and preferably 0.5 to 8% by mass.
  • this invention relates also to the method of improving the dispersibility to the liquid of the formulation containing a polysaccharide thickener. As described above, this method can be carried out by granulating a raw material containing gum arabic and a thickening polysaccharide other than gum arabic using a binder liquid containing gum arabic.
  • a method of granulating a granulation raw material containing gum arabic and a thickening polysaccharide other than gum arabic using a binder liquid containing gum arabic can be performed according to the method described above.
  • the dispersibility to the liquid of the formulation containing a thickening polysaccharide can be improved.
  • the dispersibility to the liquid of a thickening polysaccharide containing formulation can be improved, providing the desired viscosity expression derived from a thickening polysaccharide.
  • the thickening polysaccharides used in the examples are as follows.
  • Xanthan gum “SAN ACE [registered trademark] C” manufactured by San-Ei Gen FFI Co., Ltd.
  • Carrageenan “Sun Support [registered trademark] P-30” (Lambda type carrageenan formulation) manufactured by San-Ei Gen FFI Co., Ltd.
  • Gum arabic "Gum Arabic SD” manufactured by Saneigen FFI Co., Ltd.
  • Pullulan Hayashibara Co., Ltd., “Food additive pullulan fine powder”
  • ⁇ Dispersibility test of thickening polysaccharide-containing preparation> (1) 100 g of ion-exchanged water (20 ° C.) was put into a 200 mL beaker, and 2 g of the prepared thickening polysaccharide-containing preparation was added thereto, and left for 3 seconds. (2) After standing, the mixture was stirred for 30 seconds using a spatula. Stirring was performed at a speed of stirring the beaker four times per second (hand stirring at 240 rpm). (3) The state of lumps after stirring for 30 seconds was visually evaluated. The appearance of the dama was evaluated according to the following criteria.
  • ⁇ Viscosity expression test of thickening polysaccharide-containing preparation (1) 100 g of ion-exchanged water (20 ° C.) was placed in a 200 mL beaker, and 2 g of the prepared thickening polysaccharide-containing preparation was added while stirring using a spatula, and stirred for 30 seconds. Stirring was performed at a speed of stirring the beaker four times per second (hand stirring at 240 rpm). (2) The stirred solution was transferred to a screw bottle and allowed to stand, and the change in viscosity over time was measured.
  • the change in viscosity over time is defined as the viscosity after 0 minutes, 3 minutes, 5 minutes, 10 minutes, 15 minutes, and 30 minutes after 1 minute from the addition of the thickening polysaccharide-containing preparation to ion-exchanged water. It was measured. The viscosity was measured by rotating at 12 rpm for 1 minute using a BL type rotational viscometer (model number TVB-10M, manufactured by Toki Sangyo Co., Ltd.). (3) The viscosity ratio A / B was determined by setting the viscosity after 0 minute to A (mPa ⁇ s) and the viscosity after 30 minutes to B (mPa ⁇ s).
  • Example 1 and Comparative Example 1-2 an aqueous solution of 8.3% by mass gum arabic was used as the binder solution.
  • the aqueous gum arabic solution was prepared by adding and dissolving gum arabic in ion exchange water at 20 ° C.
  • Comparative Examples 1-1, 1-3, and 1-4 ion-exchanged water was used as the binder liquid.
  • Example 1 Powdered xanthan gum 99 g, gum arabic 30 g, potassium chloride 4.5 g and dextrin 151.5 g of granulated raw material (raw material mixture) 285 g was sprayed with the prepared binder liquid 180 g to prepare a fluidized bed. Granulation was performed to prepare a thickening polysaccharide-containing preparation.
  • Comparative Example 1-1 Powdered xanthan gum 99 g, potassium chloride 4.5 g and dextrin 196.5 g of granulated raw material (raw material mixture) 300 g was sprayed with 150 g of ion-exchanged water as a binder liquid to form a fluidized bed.
  • Granulation was performed to prepare a thickening polysaccharide-containing preparation.
  • Comparative Example 1-2 180 g of the prepared binder liquid was sprayed on 285 g of granulated raw material (raw material mixture) of 99 g of powdered xanthan gum, 4.5 g of potassium chloride and 181.5 g of dextrin, and fluidized bed granulation was performed. And a thickening polysaccharide-containing preparation was prepared.
  • Comparative Example 1-3 Powdered xanthan gum 99 g, gum arabic 15 g, potassium chloride 4.5 g and dextrin 181.5 g granulated raw material (raw material mixture) 300 g was sprayed with 150 g of ion-exchanged water as a binder liquid. Then, fluidized bed granulation was performed to prepare a thickening polysaccharide-containing preparation.
  • Comparative Example 1-4 Powdered xanthan gum 99 g, gum arabic 45 g, potassium chloride 4.5 g and dextrin 151.5 g granulated raw material (raw material mixture) 300 g was sprayed with 150 g of ion-exchanged water as a binder liquid. Then, fluidized bed granulation was performed to prepare a thickening polysaccharide-containing preparation.
  • the prepared polysaccharide-containing preparation was subjected to a dispersibility test and a viscosity expression test.
  • Table 2 shows the results of the dispersibility test
  • Table 3 shows the results of the viscosity development test.
  • Comparative Examples 1-1 to 1-4 since many lumps of 5 mm or more existed, viscosity development was not tested.
  • the dispersibility test of the present example is carried out by adding the thickening polysaccharide-containing preparation to water and then allowing it to stand for 3 seconds, and further stirring under weak stirring conditions such as manual stirring. It is an easy and severe test. Therefore, in the thickened polysaccharide-containing preparations of Comparative Examples 1-1 to 1-4, a large number (30 or more) of large lumps of 5 mm or more occurred.
  • the thickened polysaccharide-containing preparation of Example 1 prepared by granulating a granulating raw material containing xanthan gum and gum arabic using a binder liquid containing gum arabic was more remarkable than the comparative example. It was a preparation in which the occurrence of lumps was suppressed.
  • Example 1 Specifically, although there was some lumps, the size was small with less than 2 mm in diameter. Moreover, as shown in Table 3, the thickened polysaccharide-containing preparation of Example 1 exhibited excellent viscosity expression. Specifically, the viscosity at 0 minutes was 69% of the viscosity after 30 minutes, indicating that the viscosity can be quickly imparted to water.
  • the thickening polysaccharide-containing preparation of Example 1 is further provided with a desired viscosity expression property even though the occurrence of lumps is suppressed and the dispersibility in a liquid is excellent. confirmed.
  • Example 2 An aqueous solution containing 8.3% by mass of gum arabic was used as a binder solution.
  • the binder liquid was prepared by adding and dissolving gum arabic in ion exchange water (20 ° C.).
  • Comparative Example 2 Ion exchange water was used as a binder liquid.
  • Example 2 Powdered xanthan gum 99g, gum arabic 45g, potassium chloride 4.5g and dextrin 136.5g granulated raw material (raw material mixture) 285g, sprayed the prepared binder liquid 180g, fluidized bed construction Granulation was performed to prepare a thickening polysaccharide-containing preparation.
  • Comparative Example 2 Powdered xanthan gum 99 g, gum arabic 60 g, potassium chloride 4.5 g and dextrin 136.5 g of granulated raw material (raw material mixture) 300 g was sprayed with 150 g of the prepared binder liquid to prepare a fluidized bed. Granulation was performed to prepare a thickening polysaccharide-containing preparation.
  • Example 2 The prepared polysaccharide-containing preparations of Example 2 and Comparative Example 2 were subjected to a dispersibility test.
  • the thickening polysaccharide-containing preparation of Example 2 had almost no lumps (5 lumps less than 2 mm), indicating that the preparation was extremely excellent in dispersibility (FIG. 2).
  • the thickening polysaccharide-containing preparation of Comparative Example 2 had 20 or more lumps of about 2 mm, and the dispersibility was insufficient.
  • Table 5 shows the results of the viscosity development test on the thickened polysaccharide-containing preparations of Example 2 and Comparative Example 2.
  • the thickened polysaccharide-containing preparation of Example 2 has a viscosity at 0 minutes of 75% of the viscosity after 30 minutes, is excellent in viscosity expression, and can quickly impart viscosity to water. It has been shown.
  • Example 2 the thickening polysaccharide-containing preparation of Example 2 is further provided with a desired viscosity expression property even though the occurrence of lumps is suppressed and the dispersibility in liquid is excellent. confirmed.
  • Example 3 An aqueous solution containing 8.3% by mass of gum arabic was used as a binder solution.
  • the binder liquid was prepared by adding and dissolving gum arabic in ion exchange water (20 ° C.). Comparative Example 3: Ion exchange water was used as a binder liquid.
  • Example 3 Powdered xanthan gum 99g, carrageenan 6g, gum arabic 45g, potassium chloride 4.5g and dextrin 130.5g granulated raw material (raw material mixture) 285g, sprayed the prepared binder liquid 180g, Fluidized bed granulation was performed to prepare a thickening polysaccharide-containing preparation.
  • Comparative Example 3 Powdery xanthan gum 99 g, carrageenan 6 g, potassium chloride 4.5 g and dextrin 190.5 g of granulated raw material (raw material mixture) 300 g was sprayed with 150 g of ion-exchanged water as a binder liquid and flowed Layered granulation was performed to prepare a thickening polysaccharide-containing preparation.
  • Example 3 the thickening polysaccharide-containing preparation of Example 3 is further provided with a desired viscosity expression property despite the suppression of the occurrence of lumps and excellent dispersibility in liquids. confirmed.
  • a binder solution was prepared according to the following.
  • the gum arabic-containing aqueous solution was prepared by adding and dissolving gum arabic in ion exchange water (20 ° C.).
  • modified gum arabic (“SUPER GUM EM10”, manufactured by Saneigen FFI Co., Ltd.) was used as gum arabic.
  • Example 4-1 Aqueous solution containing 4% by weight of gum arabic
  • Example 4-2 Aqueous solution containing 1% by weight of gum arabic
  • Example 4-3 Aqueous solution containing 7.5% by weight of gum arabic
  • Example 4 -4 Aqueous solution containing 5% by weight of gum arabic
  • Example 4-5 Aqueous solution containing 6% by weight of gum arabic
  • Example 4-1 Powdered granulated raw material (raw material mixture) of 294 g of powdered xanthan gum 75 g, gum arabic 15 g, potassium chloride 6 g and dextrin 198 g was sprayed with 150 g of the prepared binder liquid to obtain fluidized bed granulation. And a thickening polysaccharide-containing preparation was prepared.
  • Example 4-2 150 g of the prepared binder liquid was sprayed on 298.5 g of a granulated raw material (raw material mixture) of 75 g of powdery xanthan gum, 30 g of gum arabic, 6 g of potassium chloride and 187.5 g of dextrin, and fluidized. Layered granulation was performed to prepare a thickening polysaccharide-containing preparation.
  • Example 4-3 To a powdered raw material (raw material mixture) 285 g of powdery xanthan gum 111 g, gum arabic 30 g, potassium chloride 9 g and dextrin 135 g, 200 g of the prepared binder liquid is sprayed to obtain fluidized bed granulation.
  • Example 4-4 To 1502.5 g of a granulated raw material (raw material mixture) of 75 g of powdery xanthan gum, 22.5 g of gum arabic, 9 g of sodium citrate and 186 g of dextrin, sprayed with 150 g of the prepared binder liquid, Fluidized bed granulation was performed to prepare a thickening polysaccharide-containing preparation.
  • Example 4-5 Fluidized bed granulation was performed by spraying 150 g of the prepared binder liquid to 291 g of a granulated raw material (raw material mixture) of 75 g of powdery xanthan gum, 21 g of gum arabic, 9 g of sodium gluconate and 186 g of dextrin. And a thickening polysaccharide-containing preparation was prepared.
  • modified gum arabic (“SUPER GUM EM10”, manufactured by Saneigen FFI Co., Ltd.) was used as gum arabic.
  • the prepared polysaccharide-containing preparation was subjected to a dispersibility test and a viscosity expression test.
  • Table 9 shows the results of the dispersibility test
  • Table 10 shows the results of the viscosity development test.
  • any of the thickening polysaccharide-containing preparations of Examples 4-1 to 4-5 the occurrence of lumps is suppressed and it has excellent dispersibility in liquids. confirmed.
  • the thickening polysaccharide-containing preparation of Example 4-3 had a high xanthan gum content of 37% by mass, and no lumps were generated despite the conditions where dams were particularly likely to occur. Further, as is clear from Table 10, it was confirmed that any of these thickening polysaccharide-containing preparations had the desired viscosity expression.
  • aqueous solution containing 7.2% by mass of gum arabic was prepared as a binder solution.
  • the aqueous solution was prepared by adding and dissolving gum arabic in ion-exchanged water (20 ° C.).
  • 287.1 g of a granulated raw material (raw material mixture, primary granulated raw material) of 150 g of powdery xanthan gum, 30 g of gum arabic, 12.9 g of potassium chloride and 94.2 g of dextrin were prepared.
  • 180 g of the prepared binder liquid was sprayed on 287.1 g of the granulated raw material, and fluidized total granulation was performed to prepare a primary granulated product.
  • Ion exchange water was used as the binder liquid.
  • 150 g of ion-exchanged water as a binder liquid is sprayed onto 210 g of the prepared primary granulated product 210 g and 90 g of dextrin 90 g granulated raw material (secondary granulated raw material), fluidized bed granulation is performed, and thickening polysaccharide is contained.
  • a formulation was prepared.
  • Example 5 For the thickening polysaccharide-containing preparation of Example 5, the same procedure as in Example 1 was conducted except that the standing time after adding the thickening polysaccharide-containing preparation to ion-exchanged water was changed from 3 seconds to 5 seconds. A dispersibility test was performed. The longer the standing time after adding the thickening polysaccharide-containing preparation to the liquid, the more likely it will be. Therefore, although this condition is a condition that makes it easier to generate lumps, the thickening polysaccharide-containing preparation of Example 5 did not generate lumps (FIG. 3).
  • the thickening polysaccharide-containing preparation of Example 5 was excellent in viscosity expression.
  • Example 5 the thickening polysaccharide-containing preparation of Example 5 was suppressed in the occurrence of lumps, was excellent in dispersibility in a liquid, and had a desired viscosity expression. Moreover, even when it was manufactured by two-step granulation in this way, it was confirmed that a thickening polysaccharide-containing preparation excellent in dispersibility and further having a desired viscosity expression could be manufactured.
  • aqueous solution containing 1.7% by mass of gum arabic and 3.3% by mass of pullulan was prepared.
  • the aqueous solution was prepared by adding and dissolving gum arabic and pullulan in ion-exchanged water (20 ° C.).
  • Ion exchange water was used as the binder liquid.
  • 120 g of granulated raw material (secondary granulated raw material) of 150 g of the prepared primary granulated material and 150 g of dextrin is sprayed with 120 g of ion-exchanged water as a binder liquid, fluidized bed granulated, and contains thickening polysaccharide.
  • a formulation was prepared.
  • the prepared polysaccharide-containing preparation was subjected to a dispersibility test and a viscosity expression test. The results are shown in Table 14.
  • Example 6 Although the thickening polysaccharide-containing preparation of Example 6 had a high thickening polysaccharide content, the dispersibility was extremely good, and no lumps occurred. Moreover, the viscosity expression was also excellent. Thus, even if the content of the thickening polysaccharide and the type thereof were changed, the dispersibility was extremely good and the viscosity expression was also excellent.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Jellies, Jams, And Syrups (AREA)
  • Medicinal Preparation (AREA)
  • General Preparation And Processing Of Foods (AREA)

Abstract

L'invention concerne un procédé de production d'une préparation contenant un épaississant polysaccharidique, avec lequel la formation de grumeaux est réduite lorsque la préparation contenant un épaississant polysaccharidique est ajoutée à un liquide, et dotée de fonctions conférant une viscosité et de gélification excellentes inhérentes aux épaississants polysaccharidiques. Une préparation contenant un épaississant polysaccharidique est produite par granulation d'une matière première de granulation à l'aide d'un fluide liant contenant de la gomme arabique, ledit matériau brut de granulation contenant de la gomme arabique et un épaississant polysaccharidique autre que de la gomme arabique.
PCT/JP2016/077587 2015-09-17 2016-09-16 Procédé de production d'une préparation contenant un épaississant polysaccharidique WO2017047803A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2017540038A JP6800860B2 (ja) 2015-09-17 2016-09-16 増粘多糖類含有製剤の製造方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2015-183690 2015-09-17
JP2015183690 2015-09-17

Publications (1)

Publication Number Publication Date
WO2017047803A1 true WO2017047803A1 (fr) 2017-03-23

Family

ID=58289516

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2016/077587 WO2017047803A1 (fr) 2015-09-17 2016-09-16 Procédé de production d'une préparation contenant un épaississant polysaccharidique

Country Status (2)

Country Link
JP (1) JP6800860B2 (fr)
WO (1) WO2017047803A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06166630A (ja) * 1992-07-10 1994-06-14 Johnson & Johnson Merck Consumer Pharmaceut Co. 車前子−ハイドロコロイドゴム組成物
JP2006519265A (ja) * 2003-02-28 2006-08-24 バイエル ファーマシューティカルス コーポレーション 癌その他の疾患の治療に有用な新規な二環尿素誘導体
JP2015514119A (ja) * 2012-04-10 2015-05-18 アルピニア・ローダナム・インスティテュート・オブ・フィトファーマシューティカル・サイエンシーズ・アクチェンゲゼルシャフトＡｌｐｉｎｉａ Ｌａｕｄａｎｕｍ Ｉｎｓｔｉｔｕｔｅ Ｏｆ Ｐｈｙｔｏｐｈａｒｍａｃｅｕｔｉｃａｌ Ｓｃｉｅｎｃｅｓ Ａｇ 湿式造粒方法およびアラビアゴムを含む粒状材料
JP2015136315A (ja) * 2014-01-22 2015-07-30 三栄源エフ・エフ・アイ株式会社 固形状糊料製剤

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06166630A (ja) * 1992-07-10 1994-06-14 Johnson & Johnson Merck Consumer Pharmaceut Co. 車前子−ハイドロコロイドゴム組成物
JP2006519265A (ja) * 2003-02-28 2006-08-24 バイエル ファーマシューティカルス コーポレーション 癌その他の疾患の治療に有用な新規な二環尿素誘導体
JP2015514119A (ja) * 2012-04-10 2015-05-18 アルピニア・ローダナム・インスティテュート・オブ・フィトファーマシューティカル・サイエンシーズ・アクチェンゲゼルシャフトＡｌｐｉｎｉａ Ｌａｕｄａｎｕｍ Ｉｎｓｔｉｔｕｔｅ Ｏｆ Ｐｈｙｔｏｐｈａｒｍａｃｅｕｔｉｃａｌ Ｓｃｉｅｎｃｅｓ Ａｇ 湿式造粒方法およびアラビアゴムを含む粒状材料
JP2015136315A (ja) * 2014-01-22 2015-07-30 三栄源エフ・エフ・アイ株式会社 固形状糊料製剤

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TORU HARA: "Sanko Shiryo -Han'yo Iyakuhin Tenkabutsu Ichiranhyo", JITSUYO IYAKUHIN TENKABUTSU, KAGAKU KOGYOSHA, 1974, pages 257 - 261 *

Also Published As

Publication number Publication date
JPWO2017047803A1 (ja) 2018-07-05
JP6800860B2 (ja) 2020-12-16

Similar Documents

Publication Publication Date Title
JP7149260B2 (ja) 増粘多糖類含有製剤の製造方法
KR20060011955A (ko) 감소된 점도의 카라기난을 함유하는 균질한 열가역성 겔 및이로부터 제조된 제품
TWI653987B (zh) Hyaluronic acid and/or a salt thereof, a method for producing the same, and a food, a cosmetic, and a pharmaceutical containing the hyaluronic acid and/or a salt thereof
JP5909791B1 (ja) キサンタンガム造粒物及び増粘用組成物
JP4723047B1 (ja) 分散性及び粘度発現性を兼ね備えた増粘化剤
JP4044128B1 (ja) タンパク質含有液状組成物用増粘化剤
JP7235437B2 (ja) 増粘用液状組成物
JP6713728B2 (ja) 液状増粘剤
JP6416479B2 (ja) 固形状糊料製剤
JP6800861B2 (ja) 増粘多糖類含有製剤の製造方法
JP5721616B2 (ja) ゲル状飲食品組成物の製造方法およびゲル化剤
JP5088867B2 (ja) 咀嚼・嚥下補助剤
TW201628627A (zh) 寡糖製劑以及其製造方法
JP4338945B2 (ja) 溶解性が改善された水溶性高分子
JP2016104710A (ja) 錠剤またはカプセル成形物
WO2017047803A1 (fr) Procédé de production d'une préparation contenant un épaississant polysaccharidique
JP2013234291A (ja) 増粘用組成物
JP2017055763A (ja) 糊料製剤
JP2006036644A (ja) グルコサミン顆粒の製造方法、グルコサミン顆粒及びグルコサミン錠剤
JP2004208562A (ja) 増粘用添加物
JP6538336B2 (ja) 固体状組成物
JP6116895B2 (ja) デンプン含有飲食品用ゲル化剤
CN107105735B (zh) 含凝胶多糖组合物、及包含含凝胶多糖组合物的制品
JP4844901B2 (ja) キトサン含有粉体
JP4178361B2 (ja) キトサン含有粉体

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 16846674

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2017540038

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 16846674

Country of ref document: EP

Kind code of ref document: A1