WO2017030330A1 - 산양유를 함유한 액상 조제유 조성물 - Google Patents

산양유를 함유한 액상 조제유 조성물 Download PDF

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WO2017030330A1
WO2017030330A1 PCT/KR2016/008932 KR2016008932W WO2017030330A1 WO 2017030330 A1 WO2017030330 A1 WO 2017030330A1 KR 2016008932 W KR2016008932 W KR 2016008932W WO 2017030330 A1 WO2017030330 A1 WO 2017030330A1
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Prior art keywords
milk
composition
casein
goat
liquid
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PCT/KR2016/008932
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English (en)
French (fr)
Korean (ko)
Inventor
김승수
신효리
박상기
권혁선
정규창
최창일
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주식회사 엘지생활건강
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Priority claimed from KR1020150116254A external-priority patent/KR101640890B1/ko
Priority claimed from KR1020160086860A external-priority patent/KR102050578B1/ko
Application filed by 주식회사 엘지생활건강 filed Critical 주식회사 엘지생활건강
Priority to CN201680042883.XA priority Critical patent/CN107846914A/zh
Publication of WO2017030330A1 publication Critical patent/WO2017030330A1/ko

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/15—Reconstituted or recombined milk products containing neither non-milk fat nor non-milk proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof

Definitions

  • the present invention relates to a liquid crude oil composition containing a goat's milk, and more particularly to a liquid crude oil composition excellent in improving the absorption and digestion of all infants by the mother's milk-friendly formulation.
  • Formulated milk is one of the artificial nutrition methods for babies. It is formulated with breast milk by combining various ingredients to compensate for the milk's component defects and to have a composition similar to breast milk.
  • Most of the formula products are commercialized products starting from a milk-derived product called cow's milk, but the current formula is somewhat different from the composition of the ideal breast milk.
  • powdered milk powder which occupies most of the current formula market, it is necessary to precisely feed the nutrients designed when dissolved in liquid form for feeding and to feed infants.
  • a problem is found in which the amount designed for acidic and temperature conditions is not fed correctly.
  • liquid formulas for feeding at a uniform crude oil concentration do not significantly deviate from the level of general milk formulations in terms of nutritional components, and thus, it was difficult to attain the charging agent of formulas such as breast milking and proper nutrition.
  • casein and whey proteins can be broadly classified. Casein is generally divided into ⁇ S1-casein, ⁇ S2-casein, ⁇ -casein, and ⁇ -casein, and whey proteins include various proteins but ⁇ Lactoglobulin and ⁇ -lactalbumin are major constituent proteins. Among them, ⁇ -casein is the main protein of breast milk, and it is easy to digest because it does not coagulate well under the action of stomach acid and makes a soft appearance.
  • ⁇ -S1 casein is the main ingredient to form a curd is a component that is low in digestibility when excessive content is known as a component that is hardly contained in breast milk but contained in milk.
  • ⁇ -S1 casein and ⁇ -casein there is still insufficient research on the overall breast milk prescription to solve allergens and digestive problems considering the effects of ⁇ -S1 casein and ⁇ -casein.
  • the formula may be prepared in solid form or in liquid form, such as powder.
  • protein, fat, carbohydrates, vitamins, and minerals are contained in the formula, which requires a lot of heat treatment such as preheating step for homogeneity and sterilization and sterilization to maintain microbial safety. During this process, inevitably physical and chemical protein denaturation occurs.
  • Whey proteins which are known to be a major factor in the mechanism of protein thermal degeneration, are accompanied by denaturation and aggregation of the protein itself. This would include irreversible protein-protein interactions of covalent bonds and protein-protein interactions of non-covalent bonds, in which case disulfide bonds of ⁇ -lactoglobulin are typical. This can occur mainly by sulfhydryl oxidation or sulfidyl-disulfide exchange, and also disulfide bonds (S-S) included in cysteine and the like bind to ⁇ -lactoglobulin to form strong aggregates leading to precipitation.
  • S-S disulfide bonds
  • the problem to be solved by the present invention is to provide a liquid preparation composition excellent in digestion absorption and allergy reduction effect of infants with a composition close to the mother's milk.
  • Another problem to be solved by the present invention is to provide a method for producing a liquid crude oil composition significantly improved over time stability and digestive absorption through process optimization.
  • the present invention includes any one or more selected from the group consisting of goat-derived milks, milk powders, and proteins, and provides a liquid crude oil composition containing 5 to 40% by weight based on the total weight of the composition.
  • the present inventors have found that, when the goat oil (goat milk) -derived product is contained in the liquid formula, the content of ⁇ S1-casein, which is a major protein that forms a curd, is low.
  • the high content of ⁇ -casein, which keeps the curd soft, makes it surprising that infants are easily absorbed when ingested and have a remarkable effect on reducing allergy in babies sensitive to milk proteins, thus completing the present invention.
  • Goat milk has a lower total casein content than milk and is relatively similar in composition to breast milk.
  • the appearance of curd by goat's milk is known to be small and soft compared to milk, and the amount of curd precipitated in the stomach is also known to be very small at 2% for goat's milk compared to 10% of milk.
  • casein of breast milk is known to be completely hydrolyzed while milk is known to be degraded to about 75 to 90%, and goat milk is about 95%, which is relatively more similar to breast milk.
  • Goat milk is also known to contain a large amount of vitamins and minerals with good bioavailability and absorption, and is known to have better absorption of nutrients such as calcium, phosphorus, and manganese than milk.
  • goat milk is relatively less ⁇ -lactoglobulin in goat milk than milk-based preparations, and goat milk is more advantageous than milk-derived preparations in stabilizing the liquid formulation composition.
  • Goat milk also exhibits different properties compared to milk in fat content and composition.
  • Goat milk fat particles are finer and more uniform than milk, and the content of intermediate chain fatty acid is high, so that the decomposition rate is fast.
  • goat milk is generally known to have about 5 times higher digestibility than milk.
  • the melting point of the fatty acid is low and the hydrolysis rate is fast, which improves the digestion characteristics. Therefore, less bile acid is required for digestion.
  • goat milk is easy and quick to absorb digestion can be used more advantageously than milk intake for infants with immature gastrointestinal function.
  • goat milk is rich in constituents such as nucleotides, sphingomyelin, and selenium, and improvement effects on atopy or allergy have been reported continuously.
  • goat-derived milks, milk powders and proteins used in the present invention have a low content of ⁇ -S1 casein, which is present in a large amount of milk, so that the protein coagulates due to gastric acid and does not interfere with digestion.
  • the goat-derived preparation is easy to digest because the curd itself is high because of the high content of ⁇ -casein similar to breast milk.
  • casein composition of known milk is about 75% for ⁇ -casein and about 25% for ⁇ -casein, and does not include ⁇ S1-casein.
  • the casein composition of milk is about 36% for ⁇ -casein, about 13% for ⁇ -casein, about 33% for ⁇ S1-casein, and about 18% for ⁇ S2-casein.
  • the casein composition of ⁇ -casein is about 62.8%, ⁇ -casein is about 10.4%, ⁇ S1- casein is about 5.6%, ⁇ S2- casein is about 21.2%, ⁇ S1- casein, ⁇ - casein compared to breast milk [Hyo-Hee Kim, Young-Seo Park, Sung-Sik Yoon, Composition of Goat Milk and Its Food and Nutritional Significance, Vol. 46, No 2, pp. 121-126 (2014)]
  • the average diameter of casein micelles of milk is 100 to 250nm
  • the average diameter of casein micelles of goat's milk has been refined to about 80nm level, it is relatively easier to absorb digestion.
  • the solid content of the liquid preparation oil composition may be included in 5 to 40% by weight, preferably 6 to 30% by weight, more preferably 7 to 25% by weight relative to the total weight of the composition.
  • the solid content is less than 5% by weight, a deficiency of the nutrient is caused, and when it is more than 40% by weight, it leads to a decrease in phase stability and an excess of the nutrient.
  • ⁇ S1-casein in the liquid crude oil composition may be included in 0.1 to 27% by weight, preferably 0.5 to 20% by weight, more preferably 1 to 15% by weight relative to the total weight of casein. If the ⁇ S1-casein content exceeds 27% by weight of the total casein problem occurs that exhibits adverse effects on the digestive absorption, such as the creation of a curd, it is practically very difficult to prepare the ⁇ S1-casein content less than 0.1% by weight in the liquid crude oil composition.
  • ⁇ -casein in the liquid crude oil composition may be included in 40 to 80% by weight, preferably 45 to 65% by weight relative to the total weight of casein.
  • the content of ⁇ -casein is less than 40% by weight of the total casein, the effect of softening the curd is hardly exhibited, and the production of more than 80% by weight thereof is very difficult to apply in reality.
  • the liquid crude oil composition of the present invention may include any one or more selected from the group consisting of goat-derived milks, milk powders, and proteins.
  • the goat-derived milk may include any one or more selected from the group consisting of sterilized milk (salt milk), sterilized milk, low fat milk, nonfat milk, and fortified milk
  • goat milk powder may include skim milk powder and whole milk powder.
  • Sweetened milk powder, and mixed milk powder, etc. may include any one or more selected from the group consisting of goat protein, goat protein, concentrated goat protein, isolated protein, whey protein, demineralized whey protein, whey protein isolate, whey isolate It may include any one or more selected from the group consisting of protein, goat milk protein, goat whey protein and the like.
  • the liquid preparation oil composition of the present invention may contain a milk-derived component
  • the content of ⁇ S1-casein in the composition is 0.1 to 27% by weight, preferably 1 to 20% by weight, more preferably, of the total casein content for breast emulsification.
  • it may contain from 1 to 15% by weight of milk derived components, or may not contain at all.
  • Liquid preparation oil composition of the present invention can be prepared through homogenization (homogenization) for the purpose of improving the digestive absorption and formulation stabilization through the finer particles.
  • homogenization homogenization
  • micronization and homogenization of the particles by an optimized homogeneous effect minimizes aggregation between composition particles that occur over time. This results in an effect of delaying the aggregation between the particles for a considerable time compared to the relatively large and non-uniform particles, so that the homogenized composition significantly improves the aggregation, separation, and precipitation phenomenon in the formulation.
  • the micronization and homogenization of the particles not only have a great effect on the stabilization of the liquid preparation oil, but also are very effective in improving the digestive absorption ability nutritionally.
  • the present invention proposes an appropriate homogeneous pressure for the homogeneous effect.
  • the homogeneous pressure may be set to 100 to 600 bar, preferably 150 to 400 bar. If the homogeneous pressure is less than 100 bar, the homogeneous effect is insignificant, resulting in a large particle size and thus a nonuniform distribution, resulting in lack of phase stability. On the other hand, when the homogeneous pressure exceeds 600 bar, the particles become extremely fine and rather cause agglomeration between the particles, which leads to a sharp drop in stability over time.
  • the liquid preparation oil composition may have a particle size of less than 0.5 ⁇ m 90% or more, preferably 95% or more.
  • the liquid preparation oil composition of the present invention has a particle size refinement process having a distribution of 90% or more of the particle size of less than 0.5 ⁇ m in the final finished product stage in order to improve digestion absorption and phase stability, in addition to the milking of the nutritional components as described above. It can be prepared through.
  • the liquid crude oil composition of the present invention may further include any one or more selected from the group consisting of emulsifiers, vitamins, fats and oils, and minerals.
  • the liquid crude oil composition of the present invention may further add an emulsifier for emulsion dispersion stability during manufacture.
  • Glycerin fatty acid esters may be used as the emulsifier, and the glycerine fatty acid esters are compounds in which fatty acids and glycerin or polyglycerol are esterified or derivatives thereof.
  • the glycerin fatty acid esters are glycerin fatty acid esters, glycerin acetic acid fatty acid esters, glycerin lactic acid fatty acid esters, glycerin citric acid fatty acid esters, glycerin zucchini acid fatty acid esters, glycerin diacetyl tartrate fatty acid esters, glycerin acetate esters, polyglycerol fatty acid esters, and It may include any one or more selected from the group consisting of polyglycerol condensed ricinoleic acid ester.
  • glycerin fatty acid ester, polyglycerol fatty acid ester, or a mixture thereof may be used as the emulsifier.
  • the liquid crude oil composition of the present invention may further include a vitamin for enhancing the nutritional component.
  • the vitamin is a fat-soluble vitamin including vitamins A, E, D and K; And water-soluble vitamins including vitamins B1, B2, B6, B12, C, pantothenic acid, niacin, folic acid, biotin, and the like.
  • the liquid crude oil composition of the present invention may further include fats and oils to supply saturated fats, unsaturated fats, and essential fatty acids to infants.
  • the fat or oil may include any one or more selected from the group consisting of soybean oil, canola oil, palm ole oil, palm oil, palm kernel oil, sunflower oil, brown rice oil, corn oil, and refined common oil.
  • the mineral in the liquid crude oil composition of the present invention is mainly used as a nutritional source, it may be additionally included for stabilizing the crude oil.
  • the mineral may include any one or more selected from the group consisting of calcium carbonate, potassium monophosphate, potassium diphosphate, potassium chloride, magnesium diphosphate, sodium hydrogencarbonate, zinc oxide, ferric pyrophosphate, manganese sulfate, potassium iodine, and the like. have.
  • the composition of the present invention can further reduce the denaturation and coagulation by heat treatment of the protein by additionally containing minerals. Especially potassium monophosphate and potassium diphosphate are preferred for the pH buffering role of the preparation.
  • the liquid preparation oil composition may be subjected to ultra high temperature (Ultra High Temperature, UHT) for the killing of microorganisms.
  • UHT Ultra High Temperature
  • the ultra high temperature short time heat treatment method is a treatment technology for preserving a liquid product by short and powerful heating at a temperature range of ultra high temperature within a short time.
  • the liquid crude oil composition of the present invention contains a large amount of carbohydrates, fats, and proteins, and is a high-nutrition composition that is easy to breed microorganisms at room temperature and for a long time storage. Although there are differences depending on the raw materials added, there are a large amount of microorganisms as in general dairy products, and there are also heat resistant bacteria that survive at refrigeration temperature and heat resistant bacteria that do not die even at high temperature heat treatment. Therefore, the liquid preparation oil composition of the present invention is preferably subjected to ultra high temperature and short heat treatment in order to completely kill microorganisms. This is due to less protein denaturation compared to the conventional retort method, and taste, odor, discoloration, etc. are better than the retort method.
  • the ultra high temperature short time heat treatment may be performed under sterilization conditions of 1 to 60 seconds, preferably 5 to 50 seconds at a temperature of 120 to 150 °C, preferably 125 to 140 °C.
  • the ultra-high temperature short time sterilization is less than 120 °C or less than 1 second, the microbial killing effect is insignificant, and when it is more than 150 °C or more than 60 seconds, precipitates are generated due to thermal denaturation or worsening of phase stability due to thermal damage.
  • the present invention (s1) is dissolved by adding any one or more selected from the group consisting of goat-derived milk, milk powder, and proteins to the dissolved fat or oil; (s2) homogenizing the mixture of step (s1) to 90% or more of particles having a particle size of less than 0.5 ⁇ m; (s3) It provides a method for preparing a liquid crude oil composition comprising the step of sterilizing the product of step (s2) by ultra-high temperature heat treatment.
  • Step (s1) of the preparation method may be prepared by adding a fat-soluble vitamin, an emulsifier, or a mixture thereof in addition to the dissolved fat or oil.
  • the production method may be prepared by additionally adding water-soluble vitamins, minerals, or mixtures thereof after cooling by adding water to the product after step (s1).
  • the preparation method may further include a step of preheating the mixture before the step (s2) in order to increase the homogenization effect.
  • the homogenization of step (s2) of the manufacturing method may be performed at a homogeneous pressure of 100 to 600 bar.
  • the ultra-high short time heat treatment of step (s3) of the manufacturing method may be performed for 1 to 60 seconds at a temperature of 120 to 150 °C.
  • the present invention provides a liquid preparation oil product filled with the liquid preparation oil composition in a plastic container having a fastening portion capable of directly fastening a feeding nipple.
  • the fastening portion may be a spiral fastening portion may be used, a configuration that can be easily fastened to each other by turning the nipple or plastic container may be used.
  • the liquid preparation oil product can be easily fed by the consumer without the need for a separate feeding bottle by using a plastic container of the nipple and direct fastening method, and dilutes the existing powdered milk to prevent microbial contamination that may occur when feeding. There is an advantage.
  • the container may be a plastic container or glass bottle made of various materials such as high density polyethylene (HDPE), low density polyethylene (LDPE), polyethylene terephthalate (PET), polypropylene (PP), polyethylene (PE), or polycarbonate (PC).
  • HDPE high density polyethylene
  • LDPE low density polyethylene
  • PET polyethylene terephthalate
  • PP polypropylene
  • PE polyethylene
  • PC polycarbonate
  • the liquid crude oil composition according to the present invention has a very good effect of improving the absorption and allergy reduction of infants and infants by containing a goat's milk-friendly formulation, and the stability and digestive absorption of the liquid crude formula over time through the process optimization is remarkably excellent.
  • Figure 1 is a photograph showing the results of the artificial gastric juice added to Comparative Example 1 and Example 5 in Experimental Example 1.
  • the milk component change used in this example is to adjust the ratio of ⁇ S1-casein and ⁇ -casein by using milk derivatives and goat milk derivatives alone or in combination according to the prescription to be designed for relative comparison between goat milk and milk. And other nutritional and stabilizing ingredients remained equal.
  • the content of goat-derived skim milk powder is gradually increased in the liquid formula to reduce ⁇ S1-casein and to increase the composition of ⁇ -casein, which is compared with the conventional milk-derived use of skim milk powder.
  • the preparation method of the Example composition in the liquid crude oil composition is quantitatively added fat-soluble vitamins, emulsifiers, lecithins and the like to the fats and oils dissolved completely at high temperature, and completely dissolved by high temperature stirring, and then in purified water of about 70 °C Stirring was started with a homomixer while slowly adding. After a certain period of time, while maintaining the temperature at about 40 °C while stirring, the goat-derived or milk-derived ingredients are mixed or added alone according to the prescription to be designed, and after a certain period of time to compare the whey protein powder, degreasing Milk powder, lactose and other pH regulators, dextrin and the like was added and stirred. After cooling by adding water, and then mixed with water-soluble vitamins and minerals to complete the stirring and completed through preheating, homogeneous, and ultra-high temperature heat treatment (UHT).
  • UHT ultra-high temperature heat treatment
  • Experimental Example 1 artificial gastric fluid addition experiments were conducted to each Example, and the digestion clinical evaluation of Experimental Example 2 was performed based on the experimental results.
  • Example Comparative Example 1 Example 1 Example 2 Example 3 Example 4 Example 5 Edible mixture oil and fat (% by weight) 2.2 2.2 2.2 2.2 2.2 2.2 2.2 2.2 Glycerin fatty acid ester (% by weight 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Skim milk powder (% by weight) (milk derived) 4.5 3.6 2.7 1.8 0.9 - Skimmed milk powder (% by weight) (goat derived) - 0.9 1.8 2.7 3.6 4.5 Whey Protein Concentrate Powder (wt%) (goat derived) One One One One One One One One One One One One Lactose (wt%) (goat derived) 3.5 3.5 3.5 3.5 3.5 3.5 3.5 3.5 3.5 3.5 3.5 3.5 3.5 3.5 Purified water and others (% by weight) To 100 To 100 To 100 To 100 To 100 To 100 To 100 To 100 ⁇ S1-casein ratio by weight of total casein (% by weight) 33 27 22 17 11 5.6 ⁇ -casein
  • Examples of the present invention was confirmed that exhibiting better digestive absorption characteristics compared to Comparative Example 1 derived from conventional milk by properly designing the ratio of ⁇ S1 and ⁇ -casein compared to the conventional milk-derived formulations.
  • Example ⁇ S1-casein ratio (% by weight) relative to total casein ⁇ -casein ratio relative to total casein (wt%) Digestive absorption clinical evaluation result Comparative Example 1 33 36 - Example 2 22 47 ⁇ Example 5 5.6 63 ⁇
  • Example 5 showed better results than Example 2. That is, in Example 5, the digestion absorption index (stool state, constipation, crying due to indigestion) was the best.
  • Examples 1 to 5 the liquid crude oil composition (Examples 1 to 5) of the present invention was compared with the casein protein derived from goat, According to the optimization of the ⁇ S1-casein and ⁇ -casein ratio was found to be relatively similar to breast milk, and as a result it was confirmed that the better digestive absorption characteristics compared to Comparative Example 1 derived from milk.
  • the samples stored at ⁇ 20 ° C. were thawed to extract protein from milk (or product), and then centrifuged at 1000 g for 10 minutes to remove fat separated from the upper layer and used for measurement.
  • the pretreated solution was added with 8 M urea, 165 mM Tris, 44 mM sodium citrate, 0.3% (v / v) aqueous solution of mercaptoethanol, and then passed through a 0.45 ⁇ m pore filter paper to separate proteins.
  • This solution contains both fat-soluble casein protein and whey protein, and the filtered protein was analyzed by fast gradient HPLC with an AxION ® TOF mass spectrometer.
  • aqueous 0.1% (v / v) trifluoroacetic acid solution and an aqueous 0.1% (v / v) acetonitrile solution was used as a mobile phase.
  • a protein having a mass range of 1000-2000 m / z was detected with a Micromass Q-TOF mass spectrometer.
  • the ⁇ , ⁇ , and ⁇ -casein protein peaks shown in the samples were quantified against the standard peaks extracted from milk, respectively.
  • Clinical evaluations were conducted in children aged 3 to 15 months of age who were selected by voluntary participation. Thirty infants were fed two weeks each of Experimental Product 1 (Example 2), Experimental Product 2 (Example 5), and Control Product (Comparative Example 1).
  • the feeding method was to feed each infant according to the usual intake method, and the caregiver was surveyed and recorded at each feeding, using the digestive absorption index as the symptom that may appear in the infant according to the degree of digestion absorption. At this time, the digestive absorption index was the crying due to the constipation state, constipation, indigestion. Evaluation according to the results was evaluated as the degree of improvement of digestive absorption index compared to the control product (Comparative Example 1). The evaluation was very good compared to the control ( ⁇ ). Good levels ( ⁇ ), equivalent levels ( ⁇ ), and poor levels were evaluated as poor (X).

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PCT/KR2016/008932 2015-08-18 2016-08-12 산양유를 함유한 액상 조제유 조성물 WO2017030330A1 (ko)

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Application Number Priority Date Filing Date Title
CN201680042883.XA CN107846914A (zh) 2015-08-18 2016-08-12 含有山羊奶的液体调制乳组合物

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2015-0116254 2015-08-18
KR1020150116254A KR101640890B1 (ko) 2015-08-18 2015-08-18 산양유를 함유한 액상 조제유 조성물
KR10-2016-0086860 2016-07-08
KR1020160086860A KR102050578B1 (ko) 2016-07-08 2016-07-08 산양유를 함유한 액상 조제유 조성물

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