WO2017010597A1 - Composition cosmétique pour le soin des cheveux contenant un facteur de croissance destiné à favoriser la régénération et la croissance des cellules folliculaires, un variant de facteur de croissance des fibroblastes de stabilité élevée, et un peptide de noggine - Google Patents

Composition cosmétique pour le soin des cheveux contenant un facteur de croissance destiné à favoriser la régénération et la croissance des cellules folliculaires, un variant de facteur de croissance des fibroblastes de stabilité élevée, et un peptide de noggine Download PDF

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WO2017010597A1
WO2017010597A1 PCT/KR2015/007650 KR2015007650W WO2017010597A1 WO 2017010597 A1 WO2017010597 A1 WO 2017010597A1 KR 2015007650 W KR2015007650 W KR 2015007650W WO 2017010597 A1 WO2017010597 A1 WO 2017010597A1
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growth factor
weight
hair
cosmetic composition
growth
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PCT/KR2015/007650
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English (en)
Korean (ko)
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신항철
박연희
선승택
오종광
유진수
임성훈
김규범
김동환
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(주)피앤피바이오팜
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth

Definitions

  • the present invention relates to a hair care cosmetic composition containing a growth factor that promotes regeneration and growth of hair follicle cells and a basic fibroblast growth factor variant having increased stability and nogin peptides. More specifically, the present invention relates to a cosmetic composition capable of promoting hair production and growth, inhibiting hair follicle cell death factors, inhibiting androgen hair loss, and improving blood circulation and feeding nutrients through regeneration and differentiation of hair follicle cells. .
  • Human hair has a growth cycle, the age, the rest period. The cycle is 4-7 years for females and 2-5 years for males, growing 1-1.5 cm per month. Generally, the number of human hair is about 10-120,000 and it is normal to lose 40-100 strands per day. As this normal hair cycle is affected by various causes such as genetic, environmental, and nutritional factors, hair loss progresses. Hair loss directly affects the appearance and thus provides a great concern for modern people, and the stress caused by hair loss is rather aggravating hair loss.
  • Growth factors play an important role in regulating cell growth, proliferation and differentiation. Therefore, there is a system that naturally repairs skin damage, aging, and hair loss caused by internal and external factors such as wounds and surgery, and growth factors play an important role here.
  • various growth factors are generated and maintained at a constant concentration. Growth factors in each tissue are lowered by age or by external factors, and the regeneration and division of cells are weakened, causing wrinkles, decreasing elasticity, and causing hair loss.
  • Hair loss treatments are currently being marketed by pharmaceutical companies, including oral pinesteride (propesia), which is approved by the US FDA, and minoxidil, which is an external preparation, but are less effective than expected. Or market growth is limited due to side effects such as erectile dysfunction, decreased libido, breast enlargement, and birth defects. In addition, various products using herbal-derived extracts have been introduced, but their efficacy and mechanism of activity have not been properly validated.
  • Apoptosis factors (BMP, DKK-1, TGF-beta, IL-1, FGF5, etc.) are stimulated when hair loss-causing factors such as DHT (dihydrotestosterone) or various stresses act on hair-producing hair papilla cells. TNF-alpha) is released. These factors send apoptosis signals to autologous and peripheral cells, causing the protein in the cell to degrade and hair loss to begin. Therefore, in order to suppress hair loss effectively, it is necessary to suppress the production of factors induced and produced by DHT.
  • DHT dihydrotestosterone
  • hair growth requires differentiation of stem cells into papilla cells, activation of papilla cells, and activation of Wnt / beta-catenin, a signaling signal for differentiation.
  • Wnt / beta-catenin a signaling signal for differentiation.
  • Such a prior art has a problem in that it can cause fatal side effects in women and infants or in males, and can not sustain the effects of hair loss prevention and hair growth with side effects such as acceleration of hair loss due to dermatitis.
  • the present invention solves the above problems, and the object of the present invention is derived from the necessity of the above, the object of the present invention through the regeneration and differentiation of hair follicle cells to promote the production and growth of hair, the inhibition of hair follicle cell death factors, androgenetic hair loss inhibition And it is to provide a composition that can implement blood circulation improvement and nutritional factors supply.
  • the present invention provides a stabilized basic fibroblast growth factor (stable basic Fibroblast Growth Factor, stable bFGF) [Korea Patent Application No. 10-2015-0047496], Insulin-like Growth Factor , IGF-1), Vascular Endothelial Growth Factor (VEGF), Keratinocyte Growth Factor (KGF-2), Stem Cell Factor (SCF), and Noggin )
  • stable basic Fibroblast Growth Factor stable basic Fibroblast Growth Factor
  • IGF-1 Insulin-like Growth Factor
  • VEGF Vascular Endothelial Growth Factor
  • KGF-2 Keratinocyte Growth Factor
  • SCF Stem Cell Factor
  • Noggin Provides a cosmetic composition for hair growth comprising a growth factor complex consisting of a peptide [Korea Patent Application No. 10-2013-0114644] as an active ingredient.
  • the stabilized basic fibroblast growth factor variant is preferably substituted at least two amino acids in the amino acid sequence of SEQ ID NO: 1 with serine, at least one amino acid is substituted with cysteine, the stabilization
  • the basic fibroblast growth factor is preferably substituted with serine for the 69th and 87th cysteines of SEQ ID NO: 1, and then substituted with other residues with cysteine to induce intramolecular disulfide bonds, and the amino acid substituted with cysteine
  • the stabilized basic fibroblast growth factor variant is the 69th and 87th cysteine of SEQ ID NO: 1 is substituted with serine, the 75th alanine is substituted with cysteine, the 50th histidine is tyrosine It provides a cosmetic composition, characterized in that substituted.
  • the composition comprises 0.009 ⁇ 4.628 parts by weight of growth factor complex, Superoxide Dismutase (SOD) 0.004 ⁇ 0.949 parts by weight based on 70 parts by weight of lyophilized powder, ,
  • SOD Superoxide Dismutase
  • the growth factor complex is 100 to 625 parts by weight of stabilized basic fibroblast growth factor variants, 100 to 625 parts by weight of vascular endothelial growth factor, 100 to 625 parts by weight of keratinocyte growth factor, based on 100 parts by weight of insulin-like growth factor, Stem cell growth factors preferably include 100 to 625 parts by weight, nogin peptide 100 to 3,200 parts by weight, but is not limited thereto.
  • the composition is rice (Oryza Sativa), green tea (Camellia sinensis leaf), black beans (Soybean), licorice (Licorice), Shou (Polygonum multiflorum root), Thuja occidentalis leaf, Grape seed (Grape seed), and ginseng (Panax ginseng root) extract preferably further comprises at least one, the extract is rice bran 0.05 to 15% by weight, green tea 0.05 to 15% by weight, black beans 0.05 to 15% by weight, Licorice 0.002 to 5% by weight, sewage 0.002 to 5% by weight, white leaf 0.002 to 5% by weight, grape seed 0.002 to 5% by weight, ginseng 0.002 to 5% by weight is not limited thereto.
  • the present invention provides a cosmetic composition for improving hair growth comprising the growth factor, high stability basic fibroblast growth factor variant and nogin peptide as an active ingredient.
  • composition of the present invention is very effective for inhibiting hair loss and improving hair growth.
  • the composition of the present invention is used for preventing skin aging, preventing hair loss or promoting hair growth.
  • cosmetic effective amount means an amount sufficient to achieve the skin improving efficacy of the composition of the present invention described above.
  • Cosmetic compositions of the present invention may be prepared in any formulation conventionally prepared in the art, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing It may be formulated as, oil, powder foundation, emulsion foundation, wax foundation and spray, but is not limited thereto. More specifically, it may be prepared in the form of a flexible lotion, nutrition lotion, nutrition cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray or powder.
  • the formulation of the present invention is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as the carrier component.
  • lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used, in particular in the case of a spray, additionally chlorofluorohydrocarbon, propane Propellant such as butane or dimethyl ether.
  • a solvent, solubilizer or emulsifier is used as the carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 Fatty acid esters of, 3-butylglycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan.
  • liquid carrier diluents such as water, ethanol or propylene glycol
  • suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystals Castle cellulose, aluminum metahydroxy, bentonite, agar and the like can be used.
  • the carrier component is an aliphatic alcohol sulfate, an aliphatic alcohol ether sulfate, a sulfosuccinic acid monoester, an isethionate, an imidazolinium derivative, a methyltaurate, a sarcosinate, a fatty acid amide.
  • Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.
  • the components included in the cosmetic composition of the present invention include components conventionally used in cosmetic compositions, in addition to growth factors and carrier components as active ingredients, and include, for example, conventional antioxidants, stabilizers, solubilizers, vitamins, pigments and perfumes. Phosphorus adjuvant.
  • compositions of the present invention include the above-described growth factors and high-stable basic fibroblast growth factor variants and nogin peptides as an active ingredient, the contents in common between the two are described in order to avoid excessive complexity of the present specification. Omit.
  • the cosmetic composition applied to the present example contains 0.009 to 4.628 parts by weight of growth factor complex and 0.004 to 0.949 parts by weight of superoxide dismutase, based on 70 parts by weight of lyophilized powder.
  • the hair growth factor complex of this embodiment is composed of stabilized basic fibroblast growth factor variants, insulin-like growth factor, vascular endothelial growth factor, keratinocyte growth factor, stem cell growth factor, and nogin peptides.
  • Basic fibroblast growth factor promotes the biosynthesis of collagen and elastin in the dermal layer, promotes angiogenesis of skin cells, enhances skin nutrition and elasticity, promotes hair and skin cell growth, and activates dermal papilla cells.
  • it acts as an insulin-like growth factor to increase hyaluronic acid synthesis in keratinocytes and increase the synthesis of elastin and collagen to regulate the hair cycle to maintain hair condition and prevent hair loss.
  • Insulin-like growth factors are involved in tissue formation such as bones, muscles, and nerves, acting as growth hormones, helping to generate new blood vessels, improving cell regeneration, and promoting growth of keratinocytes and regulating hair follicle growth.
  • Vascular endothelial growth factor increases plasma protein permeation of capillaries, promotes cell division and migration, promotes renal blood vessel formation, participates in vascular maintenance, increases capillary size and distribution of hair follicles and increases hair thickness and hair growth. To promote.
  • Keratin cell growth factor is involved in the growth and differentiation of keratinocytes, promotes endothelial cells and new hair growth, and protects keratinocytes from chemotherapy or ultraviolet rays to prevent cell damage and hair loss. In the early stages of hair growth, it plays an important role in crosslinking between cell generations.
  • Stem cell growth factors regulate stem and progenitor cell differentiation, regulate the growth and growth of melanocytes, and promote hair growth by regulating hair growth.
  • the nogin peptide is an antagonist of BMP (Bone Morphogenetic Protein), which is activated by DHT to inhibit hair loss by inhibiting BMP producing hair follicle cell death factor, preventing hair loss, promoting hair cell differentiation and proliferation of hair progenitor cells. Induces growth.
  • BMP Bis Morphogenetic Protein
  • Nogin peptides analogs of Noggin
  • the sequence, efficacy and effect of Nogin peptides, analogs of Noggin, are specified in the applicant's patents [Korean Patent Application No. 10-2013-0114644] (e.g., QHYLHIRPAPSDNLPLVDLIEH, HYLHIRPAPSDNLPLVDL, HYLHIRPAPSDNLPL, HYLHIRPAPSD, RYLHIMPAPSD), As described in the patent, inhibition against BMP is demonstrated.
  • Example 1 of the present invention the BMP2 activity of nogin and nogin peptides was controlled even at the minimum concentration of 0.01 mg / ml. The result was shown to decrease by less than 50% (Fig. 5).
  • the skin permeability test results of noggin and noggin peptide showed that the skin permeability was about 45% lower than that of the noggin peptide having a small size (FIG. 6). ).
  • the present invention shows the justification that nogin peptides showing similar activity to noggin protein should be used in cosmetic composition despite relatively high skin permeability.
  • Superoxide dismutase is the most potent antioxidant and inhibits the harmful effects of free radicals and prevents cell damage.It also promotes hair follicle protection and hair growth by removing excess oxides produced by excessive DHT immune cell stimulation. do.
  • the basic fibroblast growth factor of the present invention is a highly stable basic fibroblast growth factor variant developed by the applicant of the present application [Korean Patent Application No. 10-2015-0078930], weak thermodynamic stability, which is a problem of the conventionally distributed basic fibroblast growth factor. And basic fibroblast growth factor variants overcoming short half-lives were used.
  • Example 3 of the present invention stabilized basic fibroblast growth factor variants Compared to the activity according to the 24 hours 37 °C incubation test in the functional half life test (functional half life test) included in Example 3 of the present invention shows excellent stability and activity. In particular, after 24 hours, there was little activity of the native basic fibroblast growth factor, and thus no activity could be confirmed. In view of these results, it can be expected that when the natural basic fibroblast growth factor is used as a cosmetic material, it is difficult to expect a desired effect because its activity rapidly decreases during distribution and storage at room temperature. In other words, the experimental results show that it is necessary to use a stabilized basic fibroblast growth factor in place of the existing basic fibroblast growth factor for the use of cosmetic materials (FIG. 6).
  • the growth factor complex of the present invention is 100 to 625 parts by weight of stabilized basic fibroblast growth factor variants, 100 to 625 parts by weight of vascular endothelial growth factor, 100 to 625 parts by weight of keratinocyte growth factor, based on 100 parts by weight of insulin-like growth factor.
  • stem cell growth factor 100 ⁇ 625 parts by weight, nogin peptides are characterized by 100 ⁇ 3,200 parts by weight.
  • the hair care composition containing the growth factor complex and superoxide dismutase has a composition as shown in Table 1 below.
  • Table 1 shows the components and contents of the haircare composition.
  • Hair care composition applied to the present embodiment is characterized in that it comprises one or more of rice, green tea, black beans, licorice, sewage, white leaf, grape seed, and ginseng extract.
  • Rice extract contains high quality dietary fiber and vitamins, functional glycosides and unsaturated fatty acids oleic acid and linolenic acid, which help skin sedation and aging skin care.
  • Green tea extract is effective in preventing pigmentation and preventing skin convergence, such as catechins, which inhibit free radicals and contain a lot of polyphenols.
  • Black soybean extract keeps the scalp transparent and shiny by nourishing the skin with excellent antioxidant and rejuvenating effects. Excellent skin soothing effect prevents various troubles.
  • Licorice extract smoothes skin and has antibacterial properties. It has less side effects on the skin and prevents aging with cell regeneration effect.
  • Sewage extract regulates skin immunity and provides elasticity and energy to skin that is tired from aging, helping to manage vital skin. It nourishes your hair to help you keep it healthy.
  • the leaf extract has antibacterial and antiseptic effects. It is helpful for oily scalp, itching and dandruff, and it is effective in preventing hair loss.
  • Grape seed extract contains proanthocyanidins, which prolong hair growth and promote hair epithelial cell growth. In addition, it inhibits TGF-beta1 and TGF-beta2, which are representative hair loss inducing factors, to inhibit the degenerative phase induction of hair caused by differentiation and cell death of keratinocytes.
  • Ginseng extract promotes blood circulation and metabolism, creating a scalp environment and helping hair grow. Saponin contained in ginseng extract is effective in preventing inflammation of the pores and sebum of the scalp.
  • the extract of the present invention is rice 0.05 ⁇ 15% by weight, green tea 0.05 ⁇ 15% by weight, black beans 0.05 ⁇ 15% by weight, licorice 0.002 ⁇ 5% by weight, sewage 0.002 ⁇ 5% by weight, white leaf 0.002 ⁇ 5% by weight, grape seed 0.002 to 5% by weight, ginseng 0.002 to 5% by weight.
  • the base of the hair care composition can be used as long as it is commonly used, for example, purified water, butylene glycol, 1,2-hexanediol, glyoxal, modified alcohol, glycerin, sodium hyaluronate, hydride Hydroxyethyl cellulose, allantoin.
  • examples of other ingredients formulated in the present compositions include, but are not limited to, stabilizers, preservatives, thickeners, skin moisturizers, hair nutrients, and the like.
  • the hair care composition may include components that may serve to supply nutrients to hair follicles or hair growth promoting auxiliary components that are commonly used.
  • the hair care composition may include vitamins, amino acids, sodium chloride, and the like.
  • the vitamins are characterized by containing one or more selected from the group consisting of vitamin B group, choline, inositol, ascorbic acid, vitamin A, D, E, K.
  • the cosmetic composition containing a growth factor complex including the growth factor and stabilized fibroblast growth factor variant and noggin peptide of the present invention promotes regeneration and growth of hair follicle cells to promote hair growth and prevent hair loss. It works.
  • 1 is a table of patient groups of recruited patients according to the type of hair loss.
  • Figure 2 is a chart showing the effect of the hair care cosmetic material composition for the entire patient.
  • Figure 3 is a chart showing the effect on men in AGA (Androgenetic alopecia) hair loss.
  • Figure 6 is a result showing the skin permeability of nogin and nogin peptides over time.
  • Figure 7 is a comparison of the safety of the stabilized basic fibroblast growth factor variant of the present invention and the basic type of basic fibroblast growth factor in the 37 °C preservation experiment.
  • alkaline phosphatase reaction buffer was 100 mM glycine (Junsei, Cat No. 27185-0350), 1 mM MgCl 2 (Kanto, Cat No. 25009-01), 0.5% Triton, pH 8.8. It consists of X-100 (Large Gold, Cat No.8566-4400).
  • cryopreservation solution of C2C12 (ATCC no. CRL1772) cells to 10 mL of cell culture and mix well. After centrifugation at 800 rpm for 10 minutes, the supernatant is completely removed, and 10 mL of the cell culture solution is added again and mixed well. This was added to a T175 flask and 20 mL of cell culture solution was added, followed by incubation for 48 hours in a 37 ° C. carbon dioxide incubator (ASTEC, Cat No. SCI-165D). Remove the culture from the T175 flask, wash once with 10 mL PBS, and add 5 mL trypsin-EDTA. After reacting for 5 minutes in a 37 ° C.
  • BMP2 and nogin and nogin peptides were added to 20 mg acetic acid so that the concentrations were 1 mg / ml.
  • BMP2 is mixed with nogin and nogin peptides according to the seven concentration conditions in 4 mL of DMEM medium and reacted for 1 hour in advance. After removing all cultures incubated for 12 hours in a 24-well plate, the medium in which BMP2 and peptide were reacted was placed in each groove and reacted in a 37 ° C. carbon dioxide incubator for 3 days.
  • Table 2 shows the concentrations of BMP2, nogin and nogin peptides treated in DMEM medium.
  • Neoderm E (TegoScience) and PBS (Sigma, Cat No. P-5368) are prepared for this experiment. Insert a magnetic bar into the Franz cell and add 5 ml PBS. Raise the stratum corneum of Neoderm E upwards on the Franz cell. Raise the Franz cell lid on the Neoderm E and secure it completely with the clamp, then place the Franz cell in the Franz cell service system. 500 g of Nogin and Nogin peptides in 0.1 mg / ml sample were placed on Neoderm E, sealed with parafilm, and operated at 600 rpm. According to the experimental plan, 150 ul of sample to be analyzed at each time using a syringe is analyzed by HPLC (High Performance liquid Chromatography).
  • the experiment using the cell proliferation capacity was carried out.
  • the NIH-3T3 cells used in the experiment were maintained using DMEM complete medium containing 10% heat-inactivated fetal bovine serum, 100 units / ml penicillin, and 100 mg / ml streptomycin. 2x10 3 cells / well of NIH-3T3 cells were seeded on a 96 well culture plate. NIH-3T3 cells incubated for 24 hours were treated with serum-free DMEM medium after starvation in DMEM medium containing 0.5% FBS for each concentration and incubated for 12 hours.
  • MTT [3- (4,5-dimethylthiazol-2-yl) -2,5-diphenyl-2H-tetrazolium bromide] solution was added and reacted for 2 hours, followed by a formazan crystal with 100 ul of DMSO. Was dissolved. Absorbance was measured at 540 nm using a spectrophotometer. Drug sensitivity was compared as a percentage of drug-treated wells for absorbance of untreated drug (control).
  • the hair care composition was used once daily.
  • the cosmetics dissolved in the freeze-dried powder in 15 ml hair base was used around 0.5-1 ml depending on the progress.
  • the percentage of increase in density and thickness respectively was 0%, 0-5%, 5-10%, 10-15%, The effect was determined by dividing by> 15%.
  • hair density and thickness were measured by image analysis, and the average hair density increased by 10.05% and hair thickness by 9.55%, showing a significant increase in statistical analysis (p ⁇ 0.0001, Table 3).
  • the effect on hair density was 3 in 0%, 25 in 0-5%, 30 in 5-10%, 17 in 10-15%, and 26 in> 15%.
  • the effect on hair thickness was 0% in 5, 0-5% in 37, 5-10% in 20, 10-15% in 15, and> 15% in 24 ( Figure 2).
  • the average increase rate of hair density in hair image analysis was 10.60%, which significantly increased after treatment (p ⁇ 0.0001). 0% were 2, 0-5% were 12, 5-10% were 15, 10-15% were 9, and> 15% were 13. The average increase in thickness was 10.20%, and the thickness was also significantly increased after treatment (p ⁇ 0.0001). 0% were 3, 0-5% were 16, 5-10% were 10, 10-15% were 7, and> 15% were 15 (Table 3, Figure 3).
  • the average hair growth rate was 9.50%, and the average thickness growth rate was 8.90%. Both hair density and thickness increased significantly after the procedure (p ⁇ 0.0001, Table 3). In density, 0% was 2, 0-5% was 13, 5-10% was 16, 10-15% was 8,> 15% was 11, and 0% was 2, 0-5% were 23, 5-10% were 10, 10-15% were 8, and> 15% were 8 (Fig. 4).
  • the treatment of 101 patients increased hair density in 96.8% of patients and thickness in 95.1% of patients. More patients showed an increase of more than 15% in hair density.
  • density increased by 10.60% and thickness by 10.20%, and female patients increased by 9.50% and 8.90%, respectively. Therefore, the hair care cosmetics of this embodiment through the test shows an excellent effect on the prevention and treatment of hair loss.

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Abstract

La présente invention concerne une composition cosmétique pour le soin des cheveux contenant un facteur de croissance destiné à favoriser la régénération et la croissance des cellules folliculaires, un variant de facteur de croissance des fibroblastes basique de stabilité accrue, et un peptide de Noggine. Plus particulièrement, la présente invention concerne une composition cosmétique permettant de favoriser la génération et la croissance des cheveux par la régénération et la différenciation des cellules folliculaires, l'inhibition d'un facteur apoptotique des cellules folliculaires, la suppression de la chute des cheveux d'origine androgène, et l'obtention de l'amélioration de la circulation sanguine et de l'alimentation des facteurs nutritionnels. Selon la présente invention, l'utilisation de la composition cosmétique contenant un complexe de facteurs de croissance contenant un facteur de croissance, un variant de facteur de croissance des fibroblastes stabilisé, et un peptide de Noggine, de la présente invention, a comme effet de favoriser la régénération et la croissance des cellules folliculaires, ce qui permet de favoriser la croissance des cheveux et de prévenir la perte des cheveux.
PCT/KR2015/007650 2015-07-14 2015-07-22 Composition cosmétique pour le soin des cheveux contenant un facteur de croissance destiné à favoriser la régénération et la croissance des cellules folliculaires, un variant de facteur de croissance des fibroblastes de stabilité élevée, et un peptide de noggine WO2017010597A1 (fr)

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WO2019090008A1 (fr) * 2017-11-03 2019-05-09 Skinqri, Llc Formulation permettant la pousse des cheveux à multiples facteurs
WO2021186243A1 (fr) * 2020-03-19 2021-09-23 Skingen International Inc. Compositions pour le soin de la peau comprenant au moins 8 facteurs de croissance humains recombinants et leur utilisation pour réduire les signes de vieillissement
EP3903807A4 (fr) * 2020-03-11 2022-10-05 Medicosbiotech Inc. Composition pour traiter la chute des cheveux ou stimuler la pousse des cheveux comprenant un facteur de croissance
CN115944571A (zh) * 2023-01-10 2023-04-11 河北纳科生物科技有限公司 一种促头发生长和修护发根的精华喷雾及其制备方法

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